Aliases & Classifications for Tertiary Syphilis

MalaCards integrated aliases for Tertiary Syphilis:

Name: Tertiary Syphilis 12 15
Syphilis, Tertiary 44 73
Late Syphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8200
ICD10 33 A52 A52.3 A52.9
ICD9CM 35 097.0
MeSH 44 C536774
UMLS 73 C0153188

Summaries for Tertiary Syphilis

Disease Ontology : 12 A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems.

MalaCards based summary : Tertiary Syphilis, also known as syphilis, tertiary, is related to cardiovascular syphilis and syphilis, and has symptoms including gummatous inflammation An important gene associated with Tertiary Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). Affiliated tissues include skin, liver and bone.

Related Diseases for Tertiary Syphilis

Diseases related to Tertiary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 cardiovascular syphilis 31.7 CD40LG DDX41
2 syphilis 30.2 CD40LG DDX41 EXTL3 MYH9
3 asymptomatic neurosyphilis 29.6 CD40LG DDX41 EXTL3 MYH9
4 tertiary neurosyphilis 27.8 CD40LG DDX41 EXTL3 LEFTY2 MYH9 SH3BP5
5 aortic aneurysm, familial thoracic 1 11.3
6 gummatous syphilis 11.1
7 early yaws 10.3 CD40LG EXTL3
8 syphilitic meningitis 10.2 CD40LG EXTL3
9 optic papillitis 10.2 CD40LG EXTL3
10 chorioretinitis 10.2 CD40LG EXTL3
11 urethritis 10.2 CD40LG EXTL3
12 late congenital syphilis 10.1 DDX41 EXTL3
13 neuroretinitis 10.0 CD40LG EXTL3
14 focal chorioretinitis 10.0 CD40LG DDX41
15 endocardium disease 10.0 CD40LG SH3BP5
16 immunodeficiency 17 9.9 CD40LG DDX41
17 hepatitis 9.9
18 aneurysm 9.9
19 early congenital syphilis 9.8 CD40LG MYH9
20 aging 9.8
21 arthropathy 9.8
22 acquired immunodeficiency syndrome 9.8
23 neurosyphilis 9.8
24 thrombocytopenia due to platelet alloimmunization 9.7 CD40LG MYH9
25 major affective disorder 1 9.6
26 kaposi sarcoma 9.6
27 hepatitis c virus 9.6
28 anaplastic large cell lymphoma 9.6
29 granuloma annulare 9.6
30 lymphoma 9.6
31 sarcoma 9.6
32 panniculitis 9.6
33 hepatitis c 9.6
34 cervicitis 9.6
35 synovitis 9.6
36 dermatitis 9.6
37 laryngitis 9.6
38 necrobiosis lipoidica 9.6
39 aortic aneurysm 9.6
40 elephantiasis 9.6
41 peritonitis 9.6
42 decubitus ulcer 9.6
43 amyloidosis 9.6
44 depression 9.6
45 back pain 9.6
46 primary thrombocytopenia 9.6 CD40LG MYH9
47 secondary syphilis 9.6 CD40LG DDX41 EXTL3
48 primary bacterial infectious disease 9.6 CD40LG DDX41 EXTL3
49 hypersensitivity reaction disease 9.5 CD40LG DDX41
50 hemorrhagic disease 9.5 CD40LG MYH9

Comorbidity relations with Tertiary Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Tertiary Syphilis:



Diseases related to Tertiary Syphilis

Symptoms & Phenotypes for Tertiary Syphilis

UMLS symptoms related to Tertiary Syphilis:


gummatous inflammation

Drugs & Therapeutics for Tertiary Syphilis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Central Nervous System Infections in Denmark Recruiting NCT03418441
2 Lumbar Puncture and Syphilis Outcome Recruiting NCT02031146 Not Applicable

Search NIH Clinical Center for Tertiary Syphilis

Cochrane evidence based reviews: syphilis, tertiary

Genetic Tests for Tertiary Syphilis

Anatomical Context for Tertiary Syphilis

MalaCards organs/tissues related to Tertiary Syphilis:

41
Skin, Liver, Bone, Uterus, Lung, Eye

Publications for Tertiary Syphilis

Articles related to Tertiary Syphilis:

(show top 50) (show all 98)
# Title Authors Year
1
Rapid progression to gummatous tertiary syphilis in a patient with HIV. ( 29882582 )
2018
2
A pseudotumoral facial mass revealing tertiary syphilis. ( 28543323 )
2017
3
Double Morphology: Tertiary Syphilis and Acquired Immunodeficiency Syndrome-A Rare Association. ( 29225977 )
2017
4
Tertiary syphilis in the lumbar spine: a case report. ( 28738852 )
2017
5
Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study. ( 28338084 )
2017
6
Tertiary syphilis: tubero-serpiginous and tubero-ulcerous syphilids. ( 27026572 )
2016
7
Rapid progression and overlapping of skin eruptions in a patient with secondary and tertiary syphilis co-infected with HIV. ( 27138340 )
2016
8
First report of tertiary syphilis presenting as lipoatrophic panniculitis in an immunocompetent patient. ( 27558164 )
2016
9
Nodular tertiary syphilis in an immunocompetent patient. ( 27579755 )
2016
10
Tertiary syphilis and Kaposi sarcoma mistaken for systemic sarcoidosis in an HIV-negative patient. ( 26150207 )
2015
11
A rare case of tertiary syphilis complicated with aortic aneurysm in this era of early use of highly effective antibiotics. ( 24958987 )
2014
12
Factors associated with serological cure and the serofast state of HIV-negative patients with primary, secondary, latent, and tertiary syphilis. ( 23894598 )
2013
13
Multiple embolic stroke due to aortic arch floating thrombus in latent tertiary syphilis. ( 24272985 )
2013
14
Tertiary syphilis in the cervical spine: a case report and review of the literature. ( 24436850 )
2013
15
An unusual case of epigastric and back pain: expanding descending thoracic aneurysm resulting from tertiary syphilis diagnosed with positron emission tomography. ( 24254483 )
2013
16
An annular patch of the scalp reveals tertiary syphilis. ( 23675919 )
2013
17
Cavernous sinus syndrome, an atypical presentation of tertiary syphilis: case report and review of the literature. ( 20884116 )
2011
18
Benign nodular tertiary syphilis: a rare presenting manifestation of HIV infection. ( 21382288 )
2011
19
Comparative analysis of immunohistochemistry, polymerase chain reaction and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis. ( 21410678 )
2011
20
A monstrous aneurysm of the descending aorta as a sole manifestation of tertiary syphilis treated endovascularly. ( 21447513 )
2011
21
Rapid, progressive neuropathic arthropathy of the hip in a patient co-infected with human immunodeficiency virus, hepatitis C virus and tertiary syphilis: case report. ( 21645338 )
2011
22
Tertiary syphilis mimicking hepatic metastases of underlying primary peritoneal serous carcinoma. ( 21161022 )
2010
23
Progressive painless lower limbs weakness in a dialyzed patient: undiagnosed tertiary syphilis: a case report. ( 20180955 )
2010
24
Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis. ( 20151233 )
2010
25
Occlusion of the left coronary trunk secondary to tertiary syphilis. ( 19851661 )
2009
26
Tertiary syphilis. ( 17988342 )
2007
27
Distribution of survival times of deliberate Plasmodium falciparum infections in tertiary syphilis patients. ( 16451806 )
2006
28
Neurosyphilis in a young adult: very early tertiary syphilis? ( 16336771 )
2005
29
Tertiary syphilis presenting as hepatic bull's eye lesions. ( 16432997 )
2005
30
Pressure ulcer-like presacral gummata in a patient with tertiary syphilis. ( 16722855 )
2005
31
Syphilitic gumma--cutaneous tertiary syphilis. ( 15196182 )
2004
32
Accelerated atherosclerosis in tertiary syphilis and successful treatment with saphenous vein grafting--a case report. ( 11512694 )
2001
33
Tertiary syphilis. ( 10961213 )
2000
34
Treatment of latent and tertiary syphilis. ( 10780185 )
2000
35
Nodular tertiary syphilis mimicking granuloma annulare. ( 10640938 )
2000
36
Two recent cases of tertiary syphilis. ( 10417440 )
1999
37
Oral manifestation of tertiary syphilis: case report. ( 10863399 )
1999
38
Two recent cases of tertiary syphilis. ( 10356409 )
1999
39
Tertiary syphilis. ( 10448351 )
1999
40
Anaplastic large cell lymphoma mimicking noduloulcerative tertiary syphilis. ( 9347238 )
1997
41
Molecular detection of Treponema pallidum in secondary and tertiary syphilis. ( 9205499 )
1997
42
Intraoral tertiary syphilis (gumma) in a human immunodeficiency virus-positive man: a case report. ( 8419580 )
1993
43
Tertiary syphilis of the face. ( 2050849 )
1991
44
Vertebral involvement in tertiary syphilis. ( 2224422 )
1990
45
Secondary localized amyloidosis of the cornea associated with tertiary syphilis. ( 2328590 )
1990
46
Ulcerative syphilis in acquired immunodeficiency syndrome: a case of precocious tertiary syphilis in a patient infected with human immunodeficiency virus. ( 2584468 )
1989
47
Tertiary syphilis presenting as manic depressive psychosis. ( 21927396 )
1989
48
Benign tertiary syphilis and HIV infection. ( 3140837 )
1988
49
Tertiary syphilis of the liver: CT appearance. ( 3571608 )
1987
50
Tertiary syphilis deaths--South Florida. ( 3110580 )
1987

Variations for Tertiary Syphilis

Expression for Tertiary Syphilis

Search GEO for disease gene expression data for Tertiary Syphilis.

Pathways for Tertiary Syphilis

GO Terms for Tertiary Syphilis

Sources for Tertiary Syphilis

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69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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