MCID: TRT003
MIFTS: 39

Tertiary Syphilis

Categories: Infectious diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Tertiary Syphilis

MalaCards integrated aliases for Tertiary Syphilis:

Name: Tertiary Syphilis 11 14 33
Late Syphilis 11 31 33
Syphilis, Tertiary 43 71
Late Syphilis, Unspecified 33
Late Tertiary Syphilis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:8200
ICD9CM 34 097.0
MeSH 43 C536774
NCIt 49 C128414
SNOMED-CT 68 72083004
ICD10 31 A52 A52.9
UMLS 71 C0153188

Summaries for Tertiary Syphilis

Disease Ontology: 11 A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems.

MalaCards based summary: Tertiary Syphilis, also known as late syphilis, is related to asymptomatic neurosyphilis and neurosyphilis, and has symptoms including gummatous inflammation An important gene associated with Tertiary Syphilis is MIR570 (MicroRNA 570), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and IL27-mediated signaling events. Affiliated tissues include skin, brain and liver.

Related Diseases for Tertiary Syphilis

Diseases related to Tertiary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 697)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.3 CXCL13 CD4
2 neurosyphilis 32.2 IL10 CXCL13
3 cardiovascular syphilis 31.7 TPR TCHH MIR6511A1
4 gummatous syphilis 31.6 TPR TCHH CRP CD4
5 tertiary neurosyphilis 31.2 TTPA TPR TCHH MIR570 CXCL13 CD4
6 syphilis 30.9 TPR TNF PRTN3 MIR570 CRP CD8A
7 glanders 30.3 CD8A CD4
8 elephantiasis 30.1 IL10 CD4
9 congenital syphilis 29.9 TPR CRP CD4
10 tabes dorsalis 29.9 TTPA TCHH CXCL13 CD4
11 panniculitis 29.9 CRP CD8A CD4
12 primary syphilis 29.9 TPR MIR6511A1 CD8A CD4
13 cauda equina syndrome 29.9 TNF CRP
14 latent syphilis 29.7 TPR MIR6511A1 CXCL13 CD4
15 alcohol use disorder 29.7 TNF CRP CD4
16 periostitis 29.7 TNF CRP
17 granuloma annulare 29.6 TNF CD8A CD4
18 interstitial keratitis 29.4 TNF PRTN3 CRP
19 pulmonary tuberculosis 29.4 TNF IL10 CRP
20 acquired immunodeficiency syndrome 29.4 TNF IL10 CRP CD4
21 osteomyelitis 29.4 TNF IL10 CRP
22 decubitus ulcer 29.4 TNF IL10 CRP
23 spondylitis 29.3 TNF IL10 CRP
24 chlamydia 29.3 TNF IL10 CRP
25 bronchitis 29.3 TNF IL10 CRP
26 aortitis 29.2 TNF PRTN3 CRP CD4
27 immune deficiency disease 29.2 TNF IL10 CRP CD8A CD4
28 filarial elephantiasis 29.2 TNF IL10 CD8A CD4
29 leprosy 3 29.2 TNF IL10 CD8A CD4
30 keratitis, hereditary 29.1 TNF IL10 CD8A CD4
31 secondary syphilis 29.1 TPR TNF CXCL13 CRP CD8A CD4
32 sarcoidosis 1 29.1 TNF PRTN3 IL10 CRP CD8A CD4
33 synovitis 29.1 TNF PRTN3 IL10 CRP
34 iridocyclitis 28.9 TNF IL10 CRP CD8A CD4
35 anterior uveitis 28.9 TNF IL10 CRP CD8A CD4
36 panuveitis 28.9 TNF IL10 CRP CD8A CD4
37 fungal infectious disease 28.9 TNF IL10 CRP CD8A CD4
38 meningoencephalitis 28.9 TNF IL10 CRP CD8A CD4
39 lipoprotein quantitative trait locus 28.8 TNF IL10 CRP CD8A CD4
40 disease by infectious agent 28.8 TNF PRTN3 IL10 CRP CD8A CD4
41 temporal arteritis 28.6 TNF PRTN3 IL10 CRP CD8A CD4
42 bone inflammation disease 28.6 TNF PRTN3 IL10 CRP CD8A CD4
43 exanthem 28.5 TNF PRTN3 IL10 CRP CD8A CD4
44 peripheral nervous system disease 28.5 TNF PRTN3 IL10 CRP CD8A CD4
45 connective tissue disease 28.5 TNF PRTN3 IL10 CRP CD8A CD4
46 skin disease 28.1 TNF TCHH PRTN3 IL10 CRP CD8A
47 aortic aneurysm, familial thoracic 1 11.3
48 paroxysmal cold hemoglobinuria 11.2
49 parenchymatous neurosyphilis 10.3 TPR MIR570
50 hilar lung neoplasm 10.3 CD8A CD4

Comorbidity relations with Tertiary Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Tertiary Syphilis:



Diseases related to Tertiary Syphilis

Symptoms & Phenotypes for Tertiary Syphilis

UMLS symptoms related to Tertiary Syphilis:


gummatous inflammation

Drugs & Therapeutics for Tertiary Syphilis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441

Search NIH Clinical Center for Tertiary Syphilis

Cochrane evidence based reviews: syphilis, tertiary

Genetic Tests for Tertiary Syphilis

Anatomical Context for Tertiary Syphilis

Organs/tissues related to Tertiary Syphilis:

MalaCards : Skin, Brain, Liver, Lymph Node, Bone, Spinal Cord, Tongue

Publications for Tertiary Syphilis

Articles related to Tertiary Syphilis:

(show top 50) (show all 670)
# Title Authors PMID Year
1
The Great Masquerader: Coronary Occlusion From Thrombus in Ascending Aortic Aneurysm Causing Anterior-Wall STEMI With Cardiogenic Shock. 62
36200998 2022
2
Reported Neurologic, Ocular, and Otic Manifestations Among Syphilis Cases-16 States, 2019. 62
35819903 2022
3
Tertiary Syphilis Masquerading as Oropharyngeal Cancer. 62
36237821 2022
4
Assessment of recombinant antigens Tp0100 and Tp1016 of Treponema pallidum for serological diagnosis of syphilis. 62
35908795 2022
5
Temporal Arteritis Caused by Tertiary Syphilis. 62
36047113 2022
6
Secondary Syphilis Presenting as Bilateral Simultaneous Papillitis in an Immunocompetent Individual. 62
36176871 2022
7
Performance evaluation of eight treponemal antibody tests in China. 62
36137341 2022
8
Perineal syphilitic gumma: tertiary syphilis in a developed country. 62
35768162 2022
9
Neurosyphilis presenting with focal middle cerebral artery stenosis and acute ischemic stroke: A case report. 62
35321268 2022
10
[Chest pain and chronic heart failure as a manifestation of tertiary syphilis: clinical case]. 62
35569166 2022
11
An unusual case of tertiary syphilis. 62
34905227 2022
12
Malignant Syphilis in a Female Patient: A Case Report and Mini-Review. 62
35324594 2022
13
Sudden death due to rupture of an aortic syphilitic aneurysm. 62
34655042 2022
14
Tertiary syphilis mimicking metastatic rectal cancer. 62
35355571 2022
15
Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India. 62
35958862 2022
16
A peculiar case of syphilis infection: The great imitator is on the rise. 62
35646595 2022
17
Suspected allergy to Beta-Lactam antibiotics: An infectiological perspective. 62
35141464 2022
18
Syphilitic Popliteal Pseudoaneurysm Complicated by Acute Lower-Limb Ischemia. 62
34474621 2022
19
Nodulo-ulcerative syphilis - case report and the review of literature. 62
36217907 2022
20
A rare case of palatal perforation due to tertiary syphilis. 62
36187045 2022
21
[Ocular syphilis, the rise of a forgotten disease: Retrospective study of 18 cases diagnosed at Amiens University Hospital]. 62
34736793 2021
22
Risk of HIV Diagnosis Following Bacterial Sexually Transmitted Infections in Tennessee, 2013-2017. 62
33859145 2021
23
Ocular syphilis. 62
33831337 2021
24
Oral manifestations of syphilis: an epidemiological study in southern Brazil. 62
33656756 2021
25
Syphilitic Spinal Disease: An Old Nemesis Revisited. A Case Series and Review of Literature. 62
33512899 2021
26
The Great Impostor Did It Again: Syphilitic Arthritis. 62
34567885 2021
27
Measuring the Impact of the COVID-19 Pandemic on Sexually Transmitted Diseases Public Health Surveillance and Program Operations in the State of California. 62
33859146 2021
28
Inadequate Engagement in HIV Care Among People With HIV Newly Diagnosed With a Sexually Transmitted Disease: A Multijurisdictional Analysis. 62
33633070 2021
29
Micro-CT evaluation of historical human skulls presenting signs of syphilitic infection. 62
33791870 2021
30
Charcot Spinal Arthropathy-Induced Progression From Upper to Lower Motor Neuron Bowel Syndrome. 62
34150408 2021
31
The Estimated Lifetime Medical Cost of Syphilis in the United States. 62
33492088 2021
32
Syphilitic aortitis: chronic left coronary ostial occlusion and aortic regurgitation with aortitis. 62
33098530 2021
33
Tabes Dorsalis in a Patient Presenting With Right Lower Extremity Paresthesia and Cervical Spine Pain. 62
33884252 2021
34
Syphilitic Aortic Aneurysm: A Rare Entity in the Era of Antibiotics. 62
33824800 2021
35
Concurrent benign tertiary syphilis and asymptomatic neurosyphilis in an immunocompetent patient. 62
32810327 2021
36
Contained rupture of an aortic arch aneurysm in a patient with syphilitic aortitis. A case report. 62
35096033 2021
37
Diagnosis, treatment, and notification of syphilis during pregnancy in the state of Goiás, Brazil, between 2007 and 2017. 62
34730749 2021
38
Spinal Syphilitic Gumma: A Rare Presentation of an Old Disease. 62
34188963 2021
39
Cutaneous Rosai - Dorfman disease in a patient with late syphilis and cervical cancer - case report and a review of literature. 62
33287799 2020
40
Risk Factors for the Co-infection with HIV, Hepatitis B and C Virus in Syphilis Patients. 62
33026095 2020
41
Nodular secondary syphilis in three HIV-positive patients: a case series. 62
32693735 2020
42
[Prevalence of syphilis in a hospital in the province of Buenos Aires in 8 years]. 62
32991112 2020
43
Syphilitic pancreatitis: A rare mimicker of our time. 62
32880340 2020
44
Human Immunodeficiency Virus-infected men who have sex with men with syphilis: A 5-year multicentre study in Malaysia. 62
32723993 2020
45
A Rare Case of an Abdominal Aortic Thrombus Secondary to Syphilitic Aortitis. 62
32864228 2020
46
Repair of a Syphilitic Aneurysm of the Noncoronary Sinus. 62
33152789 2020
47
Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010-2018. 62
32441638 2020
48
A rare case of tertiary syphilis spondylodiscitis of the upper cervical spine: Diagnostic and therapeutic complexity, review of literature. 62
32913606 2020
49
Time to Serological Cure and Associated Factors Among Syphilis Patients With and Without HIV in a Sexually Transmitted Infections Center, Thailand. 62
32149964 2020
50
General paresis of insane: A forgotten entity. 62
32415032 2020

Variations for Tertiary Syphilis

Expression for Tertiary Syphilis

Search GEO for disease gene expression data for Tertiary Syphilis.

Pathways for Tertiary Syphilis

GO Terms for Tertiary Syphilis

Biological processes related to Tertiary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 TNF IL10 CXCL13 CD8A CD4
2 endothelial cell apoptotic process GO:0072577 9.62 TNF IL10
3 negative regulation of lipid storage GO:0010888 9.56 TNF CRP
4 negative regulation of cytokine production involved in immune response GO:0002719 9.26 TNF IL10
5 chronic inflammatory response to antigenic stimulus GO:0002439 8.92 TNF IL10

Sources for Tertiary Syphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....