Aliases & Classifications for Tertiary Syphilis

MalaCards integrated aliases for Tertiary Syphilis:

Name: Tertiary Syphilis 12 15
Syphilis, Tertiary 44 70
Late Syphilis 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8200
ICD9CM 34 097.0
MeSH 44 C536774
NCIt 50 C128414
SNOMED-CT 67 72083004
ICD10 32 A52 A52.9
UMLS 70 C0153188

Summaries for Tertiary Syphilis

Disease Ontology : 12 A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems.

MalaCards based summary : Tertiary Syphilis, also known as syphilis, tertiary, is related to asymptomatic neurosyphilis and neurosyphilis, and has symptoms including gummatous inflammation An important gene associated with Tertiary Syphilis is CD4 (CD4 Molecule), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include skin, eye and tongue.

Related Diseases for Tertiary Syphilis

Diseases related to Tertiary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 556)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.4 CXCL13 CD4
2 neurosyphilis 32.0 IL10 CXCL13
3 gummatous syphilis 32.0 TPR TCHH CRP
4 tertiary neurosyphilis 31.8 TPR TCHH CXCL13 CD4
5 cardiovascular syphilis 31.7 TPR TCHH MIR338
6 syphilis 31.5 TPR TNF CRP CD8A CD4
7 tabes dorsalis 30.4 TCHH CXCL13 CD4
8 congenital syphilis 30.3 TPR CD4
9 arthropathy 30.1 TPR TNF CRP
10 granuloma annulare 30.0 TNF CD4
11 sarcoidosis 1 29.9 TNF CRP CD8A CD4
12 elephantiasis 29.9 IL10 CD4
13 primary syphilis 29.8 TPR CRP CD8A CD4
14 aortitis 29.8 TNF CRP CD4
15 enthesopathy 29.8 TNF CRP
16 latent syphilis 29.7 TPR CXCL13 CD8A CD4
17 secondary syphilis 29.6 TPR CXCL13 CRP CD8A CD4
18 panniculitis 29.4 TNF CRP CD8A CD4
19 acquired immunodeficiency syndrome 29.4 TNF IL10 CRP CD4
20 chlamydia 29.4 TNF IL10 CRP
21 spondylitis 29.4 TNF IL10 CRP
22 osteomyelitis 29.4 TNF IL10 CRP
23 iridocyclitis 29.2 TNF IL10 CRP CD4
24 immune deficiency disease 29.1 TNF IL10 CRP CD8A CD4
25 leprosy 3 29.0 TNF IL10 CD8A CD4
26 keratitis, hereditary 29.0 TNF IL10 CD8A CD4
27 disease by infectious agent 28.9 TNF IL10 CRP CD8A CD4
28 panuveitis 28.8 TNF IL10 CRP CD8A CD4
29 meningoencephalitis 28.8 TNF IL10 CRP CD8A CD4
30 bone inflammation disease 28.8 TNF IL10 CRP CD8A CD4
31 exanthem 28.7 TNF IL10 CRP CD8A CD4
32 malaria 28.7 TNF IL10 CRP CD8A CD4
33 dermatitis 28.7 TNF LORICRIN IL10 CD8A CD4
34 peripheral nervous system disease 28.3 TNF MIR338 IL10 CRP CD8A CD4
35 skin disease 28.1 TNF TCHH LORICRIN IL10 CRP CD8A
36 aortic aneurysm, familial thoracic 1 11.3
37 paroxysmal cold hemoglobinuria 11.1
38 panophthalmitis 10.3 CRP CD4
39 epidural abscess 10.3 CRP CD4
40 urogenital tuberculosis 10.3 CRP CD4
41 breast abscess 10.3 CRP CD4
42 pyomyositis 10.3 CRP CD4
43 suppurative lymphadenitis 10.3 CRP CD4
44 splenic abscess 10.3 CRP CD4
45 orbital cellulitis 10.3 CRP CD4
46 acute orbital inflammation 10.3 CRP CD4
47 neuroretinitis 10.3 CRP CD4
48 mediastinitis 10.3 CRP CD4
49 optic papillitis 10.3 CRP CD4
50 external ear disease 10.3 CRP CD4

Comorbidity relations with Tertiary Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Tertiary Syphilis:



Diseases related to Tertiary Syphilis

Symptoms & Phenotypes for Tertiary Syphilis

UMLS symptoms related to Tertiary Syphilis:


gummatous inflammation

Drugs & Therapeutics for Tertiary Syphilis

Search Clinical Trials , NIH Clinical Center for Tertiary Syphilis

Cochrane evidence based reviews: syphilis, tertiary

Genetic Tests for Tertiary Syphilis

Anatomical Context for Tertiary Syphilis

MalaCards organs/tissues related to Tertiary Syphilis:

40
Skin, Eye, Tongue, Lymph Node, Spleen, Spinal Cord, Pancreas

Publications for Tertiary Syphilis

Articles related to Tertiary Syphilis:

(show top 50) (show all 409)
# Title Authors PMID Year
1
Syphilitic aortitis: chronic left coronary ostial occlusion and aortic regurgitation with aortitis. 61
33098530 2021
2
Micro-CT evaluation of historical human skulls presenting signs of syphilitic infection. 61
33791870 2021
3
Oral manifestations of syphilis: an epidemiological study in southern Brazil. 61
33656756 2021
4
Concurrent benign tertiary syphilis and asymptomatic neurosyphilis in an immunocompetent patient. 61
32810327 2021
5
Syphilitic spinal disease: an old nemesis revisited. A case series and review of literature. 61
33512899 2021
6
Risk Factors for the Co-infection with HIV, Hepatitis B and C Virus in Syphilis Patients. 61
33026095 2020
7
Nodular secondary syphilis in three HIV-positive patients: a case series. 61
32693735 2020
8
A Rare Case of an Abdominal Aortic Thrombus Secondary to Syphilitic Aortitis. 61
32864228 2020
9
Syphilitic pancreatitis: A rare mimicker of our time. 61
32880340 2020
10
A rare case of tertiary syphilis spondylodiscitis of the upper cervical spine: Diagnostic and therapeutic complexity, review of literature. 61
32913606 2020
11
Repair of a Syphilitic Aneurysm of the Noncoronary Sinus. 61
33152789 2020
12
General paresis of insane: A forgotten entity. 61
32415032 2020
13
[Rapidly progressive dementia due to neurosyphilis (general paralysis). A treatable case of dementia]. 61
32841147 2020
14
Neurosyphilis Presenting as Intermittent Explosive Disorder and Acute Psychosis. 61
31938625 2019
15
[Pseudo-tumoral cutaneous tertiary syphilis]. 61
31727481 2019
16
Giant Aortic Syphilitic Aneurysm of The Ascending Aorta with Erosion in the Chest Wall: Case Report. 61
31596720 2019
17
Many Different Patterns under a Common Flag: Aortic Pathology in HIV-A Review of Case Reports in Literature. 61
31051229 2019
18
Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. 61
31230001 2019
19
Syphilis. 61
30738716 2019
20
An isotopic case study of individuals with syphilis from the pathological-anatomical reference collection of the national museum in Prague (Czech Republic, 19th century A.D.). 61
31051405 2019
21
Aortic Thrombus in a Case of Tertiary Syphilis. 61
30879853 2019
22
Modelling the risk of transfusion-transmitted syphilis: a reconsideration of blood donation testing strategies. 61
30565234 2019
23
Rapid progression to gummatous tertiary syphilis in a patient with HIV. 61
29882582 2019
24
Gummatous penile syphilis. 61
31406680 2019
25
Tertiary Syphilis (General Paralysis of the Insane) and Bipolar Disorder; the role of these two disorders in the life of famous composers. 61
30439847 2018
26
Does Schizoaffective Disorder explain the mental illnesses of Robert Schumann and Vincent Van Gogh? 61
30439846 2018
27
Tubero-Ulcero-Serpiginous Syphilid (A52.7) in Tertiary Syphilis. 61
30565550 2018
28
Acute coronary syndrome of very unusual etiology. 61
29356195 2018
29
Neurosyphilis: A Simulation Case for Emergency Medicine Residents. 61
30237945 2018
30
The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. 61
30045704 2018
31
Unusual Manifestations of Secondary Syphilis: Case Presentations. 61
29989879 2018
32
Historical reflections on neurosyphilis based on the 1826 treatise on general paralysis in demented patients by Louis Florentin Calmeil (1798-1895). 61
29169563 2018
33
A Young Boy with Persistent Nodules and Hoarseness: A Rare Presentation of Nodular Secondary Syphilis. 61
29482701 2018
34
Cerebral Syphilitic Gumma in Immunocompetent Man, Japan. 61
29350164 2018
35
An unusual cause of adrenal insufficiency and bilateral adrenal masses. 61
30002834 2018
36
An Unusual Case of Tertiary Syphilis Behaving Like Tongue Squamous Cell Carcinoma. 61
30622992 2018
37
Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus. 61
30538872 2018
38
A five year retrospective study on Syphilis in the Sexual Transmitted Disease Centre (STDC) of the teaching Hospital Umberto I in Rome. 61
29215133 2018
39
Time to development of ocular syphilis after syphilis infection. 61
28958728 2018
40
[Syphilis epidemiological report. Chile, 2016]. 61
30534908 2018
41
[Clinical manifestations of syphilis in maxillofacial area. Part II]. 61
29992943 2018
42
Syphilis of the lumbar spine: A case report and review of the literature. 61
29390306 2017
43
The Annual Economic Burden of Syphilis: An Estimation of Direct, Productivity, and Intangible Costs for Syphilis in Guangdong Initiative for Comprehensive Control of Syphilis Sites. 61
28876318 2017
44
[Neurosyphilis: an Age-old Problem that is Still Relevant Today]. 61
29037341 2017
45
A pseudotumoral facial mass revealing tertiary syphilis. 61
28543323 2017
46
Tertiary syphilis in the lumbar spine: a case report. 61
28738852 2017
47
A case report of CT-diagnosed renal infarct secondary to syphilitic aortitis. 61
28747159 2017
48
Syphilitic Aortitis Diagnosis in Clinical Setting. 61
29701397 2017
49
Usefulness of Positron Emission Tomography in Patients with Syphilis: A Systematic Review of Observational Studies. 61
28469107 2017
50
Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study. 61
28338084 2017

Variations for Tertiary Syphilis

Expression for Tertiary Syphilis

Search GEO for disease gene expression data for Tertiary Syphilis.

Pathways for Tertiary Syphilis

GO Terms for Tertiary Syphilis

Biological processes related to Tertiary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.37 TNF IL10
2 negative regulation of interleukin-6 production GO:0032715 9.33 TNF MIR338 IL10
3 negative regulation of lipid storage GO:0010888 9.32 TNF CRP
4 endothelial cell apoptotic process GO:0072577 9.26 TNF IL10
5 immune response GO:0006955 9.02 TNF IL10 CXCL13 CD8A CD4
6 negative regulation of cytokine production involved in immune response GO:0002719 8.96 TNF IL10

Sources for Tertiary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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