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MCID: TST014
MIFTS: 55

Testicular Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Testicular Cancer

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MalaCards integrated aliases for Testicular Cancer:

Name: Testicular Cancer 12 54 38 56 44 15 3
Testicular Carcinoma 56 17
Testicular Neoplasms 45 74
Testicular Malignant Germ Cell Tumor 74
Childhood Neoplasm of the Testis 12
Pediatric Testicular Neoplasm 12
Childhood Testicular Neoplasm 74
Malignant Neoplasm of Testis 74
Carcinoma of the Testis 74
Cancer of the Testes 54
Testicular Neoplasm 17
Neoplasm of Testis 12
Testicular Tumor 12
Testis Neoplasm 12
Testis Cancer 12

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2998
KEGG 38 H00023
ICD9CM 36 186
MeSH 45 D013736
SNOMED-CT 69 94087009
ICD10 34 C62 C62.9 C62.90
Sources

Summaries for Testicular Cancer

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MedlinePlus : 44 Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of 20 and 39. It is also more common in men who Have had abnormal testicle development Have had an undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your testicles or groin area. Doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. Most cases can be treated, especially if found early. Treatment options include surgery, radiation, and/or chemotherapy. Regular exams after treatment are important. Treatments may also cause infertility. If you may want children later on, you should consider sperm banking before treatment. NIH: National Cancer Institute

MalaCards based summary : Testicular Cancer, also known as testicular carcinoma, is related to testicular seminoma and testicular disease. An important gene associated with Testicular Cancer is TDRG1 (Testis Development Related 1), and among its related pathways/superpathways are G alpha (s) signalling events and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Cisplatin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and bone.

Disease Ontology : 12 A male reproductive system cancer that is located in the testicles.

Wikipedia : 77 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.... more...

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Related Diseases for Testicular Cancer

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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 testicular seminoma 32.5 AFP CGA CGB3
2 testicular disease 32.1 AFP INSL3 RXFP2
3 endodermal sinus tumor 32.1 AFP CGB3
4 testicular germ cell cancer 32.0 ALPP AR XIST
5 cryptorchidism, unilateral or bilateral 31.7 AR AZF1 CGA CGB5 INSL3 RXFP2
6 teratoma 30.6 AFP CGA CGB3
7 nonseminomatous germ cell tumor 30.4 AFP CGB5
8 gynecomastia 30.4 AR CGA SHBG
9 germ cell cancer 30.3 AFP ALPP AR CGA
10 extragonadal germ cell cancer 30.1 AFP CGB5
11 hydrocele 30.0 AFP CGA
12 mixed germ cell tumor 30.0 AFP CGA CGB3
13 seminoma 29.9 AFP ALPP CGA CGB3 CGB5 MAGEA4
14 androgen insensitivity syndrome 29.9 AR CGA SHBG
15 choriocarcinoma 29.9 ALPP CGA CGB3 CGB5
16 gonadal disease 29.9 AFP AR SHBG
17 varicocele 29.8 AZF1 CGA SHBG
18 squamous cell carcinoma 29.3 BOK-AS1 CTAG1B MAGEA4 STK11
19 testicular germ cell tumor 29.3 AFP ALPP AR CGB3 STK11
20 rete testis neoplasm 12.2
21 testicular cancer, childhood 12.1
22 resistance to bleomycine in the treatment of testicular cancer 12.1
23 embryonal carcinoma 11.5
24 testicular leydig cell tumor 11.1
25 rete testis adenocarcinoma 11.1
26 testis sarcoma 11.1
27 spermatocele 11.1
28 testicular brenner tumor 11.1
29 gynandroblastoma 11.1
30 testis refractory cancer 11.0
31 ovarian mixed germ cell neoplasm 10.4 AFP CGA
32 polyembryoma 10.4 AFP CGA
33 sacrococcygeal teratoma 10.4 AFP CGA
34 malignant sertoli cell tumor 10.4 AFP CGB5
35 triploidy 10.4 AFP CGA
36 corpus luteum cyst 10.4 AFP CGB5
37 tuberculous epididymitis 10.4 AFP CGB3
38 infertility 10.4
39 placental site trophoblastic tumor 10.3 CGB3 CGB5
40 47, xxy 10.3 AR SHBG
41 physical disorder 10.3 AFP INSL3 RXFP2
42 hermaphroditism 10.3 AR CGA
43 papillary hidradenoma 10.3 AR STK11
44 orofaciodigital syndrome viii 10.3 AFP CGA
45 postmenopausal atrophic vaginitis 10.3 AR SHBG
46 androgen insensitivity, partial 10.3 AR SHBG
47 chromosomal triplication 10.3 AFP CGA CGB3
48 alopecia, androgenetic, 1 10.3 AR SHBG
49 pseudovaginal perineoscrotal hypospadias 10.3 AR CGA
50 sertoli-leydig cell tumor 10.3 AFP INSL3

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to Testicular Cancer
Sources

Symptoms & Phenotypes for Testicular Cancer

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Sources

Drugs & Therapeutics for Testicular Cancer

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Drugs for Testicular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 313)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 441203 84093 2767
2
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 38904 10339178 498142
3
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
4
Testosterone enanthate Approved Phase 4,Phase 2,Phase 3 315-37-7 9416
5
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Phase 3 5949-44-0
6
Testosterone Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3 58-22-0, 481-30-1 6013 10204
7
Methyltestosterone Approved Phase 4,Phase 2,Phase 3 58-18-4 6010
8
Docetaxel Approved, Investigational Phase 4,Phase 2 114977-28-5 148124
9
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
10
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
11 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
13 interferons Phase 4,Phase 1,Phase 2
14 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
15 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Interferon Inducers Phase 4,Phase 1,Phase 2
20 Testosterone 17 beta-cypionate Phase 4,Phase 2,Phase 3
21 Anabolic Agents Phase 4,Phase 2,Phase 3
22 Androgens Phase 4,Phase 2,Phase 3
23 tyrosine Phase 4
24 Follicle Stimulating Hormone Phase 4
25 Estradiol 3-benzoate Phase 4,Phase 3
26 Estradiol 17 beta-cypionate Phase 4,Phase 3
27
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
28
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
29
Vinblastine Approved Phase 3 865-21-4 13342 241903
30
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
31
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
32
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
33
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
34
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
35
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 6857599 5310940 9887054 43805
36
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
37
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 1177-87-3
38
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
39
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 50-02-2 5743
40
Ofloxacin Approved Phase 3 82419-36-1 4583
41
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
42
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
43
Captopril Approved Phase 3 62571-86-2 44093
44
Ribavirin Approved Phase 3 36791-04-5 37542
45
Palivizumab Approved, Investigational Phase 3 188039-54-5
46
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
47
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
48
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
49
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 2826718 468682
50
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965

Interventional clinical trials:

(show top 50) (show all 293)
# Name Status NCT ID Phase Drugs
1 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 Docetaxel Combined With Carboplatin Plus Anlotinib as First Line Treatment in NSCLC Not yet recruiting NCT03799601 Phase 4 Anlotinib;Docetaxel;Carboplatin
5 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
6 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
7 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
8 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
9 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
10 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
11 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
12 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
13 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
14 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
15 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
16 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
17 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
18 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
19 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
20 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
21 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
22 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
23 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
24 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
25 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
26 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
27 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
28 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
29 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
30 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
31 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
32 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
33 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
34 Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate Active, not recruiting NCT01444820 Phase 3
35 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
36 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
37 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
38 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
39 Autologous Dendritic Cell Vaccine Loaded With Allogeneic Tumor Lysate Expression of Cancer Testis Antigens in Patients With Soft Tissue Sarcoma Unknown status NCT01883518 Phase 1, Phase 2
40 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
41 Effectiveness of an Individualized Program of Muscular Strength and Endurance Program for Improving Germ Cell Cancer Unknown status NCT02433197 Phase 1, Phase 2
42 Peptide Vaccination in Treating Patients With Esophageal Cancer (STF-II) Unknown status NCT01267578 Phase 2
43 A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer Unknown status NCT00995358 Phase 2
44 Phase II Study of S-488410 to Treat Non-small Cell Lung Cancer Unknown status NCT01592617 Phase 2 S-488410
45 Decitabine Followed by Donor Lymphocyte Infusion for Patients With Relapsed Acute Myeloblastic Leukemia(AML) After Allogeneic Stem Cell Transplantation Unknown status NCT01758367 Phase 1, Phase 2 Deciatbine(DAC)
46 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
47 Promotora-based Latino Family CVD Risk Reduction Unknown status NCT01714271 Phase 2
48 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
49 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
50 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: testicular neoplasms

Sources

Genetic Tests for Testicular Cancer

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Sources

Anatomical Context for Testicular Cancer

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MalaCards organs/tissues related to Testicular Cancer:

42
Testis, Lymph Node, Bone, Bone Marrow, Testes, T Cells, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Testicular Cancer:

20
The Testicles
Sources

Publications for Testicular Cancer

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Articles related to Testicular Cancer:

(show top 50) (show all 2761)
# Title Authors Year
1
Testicular cancer guideline adherence and patterns of care in Germany: A nationwide survey. ( 30252174 )
2019
2
Quality of Life in Long-Term Testicular Cancer Survivors With Compensated Leydig Cell Dysfunction. ( 30293923 )
2019
3
Testicular Cancer Biomarkers: A Role for Precision Medicine in Testicular Cancer. ( 30497810 )
2019
4
Re: Cumulative Burden of Morbidity among Testicular Cancer Survivors after Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study. ( 30577377 )
2019
5
Robotic retroperitoneal lymph node dissection for testicular cancer: feasibility and latest outcomes. ( 30585870 )
2019
6
Insulin-like factor 3, luteinizing hormone and testosterone in testicular cancer patients: effects of β-hCG and cancer treatment. ( 30609309 )
2019
7
The rising incidence of testicular cancer among young men in Canada, data from 1971-2015. ( 30616087 )
2019
8
Immunotherapy: last bullet in platinum refractory germ cell testicular cancer. ( 30624089 )
2019
9
Current controversies on the role of lymphadenectomy for testicular cancer for the journal: Urologic Oncology: Seminars and Original Investigations for the special seminars section on the role of lymphadenectomy for urologic cancers. ( 30630731 )
2019
10
Therapeutic supine robotic retroperitoneal lymph node dissection for post-chemotherapy residual masses in testicular cancer: technique and outcome analysis of initial experience. ( 30656537 )
2019
11
The diagnostic performance of current tumour markers in surveillance for recurrent testicular cancer: A diagnostic test accuracy systematic review. ( 30658216 )
2019
12
The puzzling incidence of testicular cancer in New Zealand: what can we learn? ( 30663250 )
2019
13
Human testis phosphoproteome reveals kinases as potential targets in spermatogenesis and testicular cancer. ( 30683686 )
2019
14
Re: Management of Pelvic Metastases in Patients with Testicular Cancer. ( 30724856 )
2019
15
Altered Molecular Pathways in the Proteome of Cryopreserved Sperm in Testicular Cancer Patients before Treatment. ( 30764484 )
2019
16
Sperm count in Swedish clinical stage I testicular cancer patients following adjuvant treatment. ( 30798330 )
2019
17
Effect of alvimopan on gastrointestinal recovery and length of hospital stay after retroperitoneal lymph node dissection for testicular cancer. ( 30854207 )
2019
18
Psychosocial Issues in Long-Term Survivors of Testicular Cancer. ( 30858829 )
2019
19
Testicular Cancer in an American Special Forces Soldier: A Case Report. ( 30859521 )
2019
20
Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients. ( 30914949 )
2019
21
Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients. ( 29358504 )
2018
22
Reply to Christian D. Fankhauser, Nico C. Grossmann, Joerg Beyer, and Thomas Hermanns' Letter to the Editor re: Sophia C. Kamran, Thomas Seisen, Sarah C. Markt, et al. Contemporary treatment patterns and outcomes for clinical stage IS testicular cancer. Eur Urol 2018;73:262-70. ( 29358058 )
2018
23
Danish translation and pilot testing of the European Organization for Research and Treatment of Cancer QLQ-TC 26 (EORTC QLQ-TC26) questionnaire to assess health-related quality of life in patients with testicular cancer. ( 29914500 )
2018
24
Quantification of the Leydig cell compartment in testicular biopsies and association with biochemical Leydig cell dysfunction in testicular cancer survivors. ( 29981219 )
2018
25
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology. ( 29935977 )
2018
26
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN. ( 29902454 )
2018
27
A Review of Outcomes and Technique for the Robotic-Assisted Laparoscopic Retroperitoneal Lymph Node Dissection for Testicular Cancer. ( 29853869 )
2018
28
Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia. ( 29662825 )
2018
29
Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance. ( 29405722 )
2018
30
Testicular cancer among US men aged 50 years and older. ( 29807233 )
2018
31
Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records. ( 29970393 )
2018
32
Physical activity and risk of testicular cancer: a systematic review. ( 29444652 )
2018
33
Thromboprophylaxis and the route of administration of chemotherapy in testicular cancer patients in German-speaking countries. ( 29417289 )
2018
34
FERTILITY MANAGMENT IN TESTICULAR CANCER- The need for establishing a standardised and evidenced based patient centric pathway. ( 29920910 )
2018
35
Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report. ( 29416867 )
2018
36
Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values. ( 29963714 )
2018
37
Non-risk-adapted Surveillance for Stage I Testicular Cancer: Critical Review and Summary. ( 29338978 )
2018
38
Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer. ( 29772568 )
2018
39
Re: Multi-Institutional Assessment of Adverse Health Outcomes among North American Testicular Cancer Survivors after Modern Cisplatin-Based Chemotherapy. ( 29310185 )
2018
40
Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark. ( 29510806 )
2018
41
Long term deficiency of vitamin D in germ cell testicular cancer survivors. ( 29765521 )
2018
42
Should survivors of childhood cancer or testicular cancer be screened for androgen deficiency? ( 29920751 )
2018
43
Ophthalmological changes of the posterior segment in patients with testicular cancer in a mixed-race population of the General Hospital of Mexico. ( 29907347 )
2018
44
Re: Singh A<i>et al</i>. Robot-assisted retroperitoneal lymph node dissection: Feasibility and outcome in postchemotherapy residual mass in testicular cancer. Indian J Urol 2017;33:304-9. ( 29345697 )
2018
45
Testicular cancer: symptoms for urgent referral are identified. ( 29970611 )
2018
46
Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study. ( 29969051 )
2018
47
Hearing loss before and after cisplatin-based chemotherapy in testicular cancer survivors: a longitudinal study. ( 29384420 )
2018
48
Testicular Cancer: Epidemiology, Diagnosis, and Management. ( 29406056 )
2018
49
Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors. ( 29775128 )
2018
50
Trends in rates of inpatients treated for testicular cancer in France, 2000-2014. ( 29952145 )
2018
Sources

Variations for Testicular Cancer

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Copy number variations for Testicular Cancer from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 61546 12 1 35400000 Gain Testicular cancer
2 202070 5 76900000 102800000 Loss Testicular cancer
3 217038 7 1 158821424 Gain Testicular cancer
4 237464 8 23300000 146274826 Gain Testicular cancer
5 262544 X 37500000 154913754 Gain Testicular cancer
6 262545 X 37500000 154913754 Gain Testicular cancer
7 266960 Y 174481503 174538309 Deletion AZF Testicular cancer
Sources

Expression for Testicular Cancer

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Search GEO for disease gene expression data for Testicular Cancer.
Sources

Pathways for Testicular Cancer

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Pathways related to Testicular Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 67
11.5 CGA INSL3 RXFP2
2
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 67
Show member pathways
 10.77 CGA CGB3 CGB5
3
Nongenotropic Androgen signaling 1
10.21 AR SHBG
Sources

GO Terms for Testicular Cancer

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Biological processes related to Testicular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.46 AR CGB3 CGB5 INSL3
2 female gamete generation GO:0007292 9.26 CGB3 CGB5
3 hormone-mediated signaling pathway GO:0009755 9.13 CGB3 CGB5 RXFP2
4 peptide hormone processing GO:0016486 8.8 CGA CGB3 CGB5

Molecular functions related to Testicular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 AR SHBG
2 hormone activity GO:0005179 9.13 CGA CGB3 INSL3
3 androgen binding GO:0005497 8.62 AR SHBG
Sources

Sources for Testicular Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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