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MCID: TST014
MIFTS: 54

Testicular Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Testicular Cancer

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MalaCards integrated aliases for Testicular Cancer:

Name: Testicular Cancer 12 53 37 55 43 3 15
Testicular Neoplasms 44 73
Testicular Malignant Germ Cell Tumor 73
Childhood Neoplasm of the Testis 12
Pediatric Testicular Neoplasm 12
Childhood Testicular Neoplasm 73
Malignant Neoplasm of Testis 73
Carcinoma of the Testis 73
Cancer of the Testes 53
Testicular Carcinoma 55
Testicular Neoplasm 29
Neoplasm of Testis 12
Testicular Tumor 12
Testis Neoplasm 12
Testis Cancer 12

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2998
ICD10 33 C62 C62.9 C62.90
ICD9CM 35 186
MeSH 44 D013736
SNOMED-CT 68 94087009
KEGG 37 H00023
Sources

Summaries for Testicular Cancer

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MedlinePlus : 43 Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of 20 and 39. It is also more common in men who Have had abnormal testicle development Have had an undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your testicles or groin area. Doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. Most cases can be treated, especially if found early. Treatment options include surgery, radiation, and/or chemotherapy. Regular exams after treatment are important. Treatments may also cause infertility. If you may want children later on, you should consider sperm banking before treatment. NIH: National Cancer Institute

MalaCards based summary : Testicular Cancer, also known as testicular neoplasms, is related to testicular germ cell cancer and testicular disease. An important gene associated with Testicular Cancer is TDRG1 (Testis Development Related 1), and among its related pathways/superpathways are G alpha (s) signalling events and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Cisplatin and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and testes.

Disease Ontology : 12 A male reproductive system cancer that is located in the testicles.

Wikipedia : 76 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.... more...

Sources

Related Diseases for Testicular Cancer

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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell cancer 32.0 ALPP AR XIST
2 testicular disease 31.9 AFP INSL3 RXFP2
3 testicular seminoma 31.9 AFP CGA CGB3 TSPY1
4 endodermal sinus tumor 31.9 AFP CGB3
5 cryptorchidism, unilateral or bilateral 31.8 AR AZF1 CGA CGB5 INSL3 RXFP2
6 teratoma 30.4 AFP CGA CGB3
7 germ cell cancer 30.3 AFP ALPP AR CGA
8 gynecomastia 30.3 AR CGA SHBG
9 nonseminomatous germ cell tumor 30.2 AFP CGB5
10 extragonadal germ cell cancer 29.9 AFP CGB5
11 choriocarcinoma 29.9 ALPP CGA CGB3 CGB5
12 hydrocele 29.8 AFP CGA
13 mixed germ cell tumor 29.8 AFP CGA CGB3
14 androgen insensitivity syndrome 29.8 AR CGA SHBG
15 gonadal disease 29.7 AFP AR SHBG
16 seminoma 29.6 AFP ALPP CGA CGB3 CGB5 MAGEA4
17 testicular germ cell tumor 29.5 AFP ALPP CGB3 STK11
18 squamous cell carcinoma 29.3 BOK-AS1 CTAG1B MAGEA4 STK11
19 rete testis neoplasm 12.2
20 testicular cancer, childhood 12.0
21 resistance to bleomycine in the treatment of testicular cancer 12.0
22 embryonal carcinoma 11.5
23 testicular microlithiasis 11.4
24 rete testis adenocarcinoma 11.1
25 testicular leydig cell tumor 11.1
26 testis sarcoma 11.1
27 spermatocele 11.0
28 testicular brenner tumor 11.0
29 gynandroblastoma 11.0
30 testis refractory cancer 11.0
31 ovarian mixed germ cell neoplasm 10.3 AFP CGA
32 polyembryoma 10.3 AFP CGA
33 sacrococcygeal teratoma 10.3 AFP CGA
34 malignant sertoli cell tumor 10.3 AFP CGB5
35 triploidy 10.3 AFP CGA
36 corpus luteum cyst 10.3 AFP CGB5
37 tuberculous epididymitis 10.3 AFP CGB3
38 placental site trophoblastic tumor 10.2 CGB3 CGB5
39 hermaphroditism 10.2 AR CGA
40 47, xxy 10.2 AR SHBG
41 orofaciodigital syndrome viii 10.2 AFP CGA
42 physical disorder 10.2 AFP INSL3 RXFP2
43 papillary hidradenoma 10.2 AR STK11
44 postmenopausal atrophic vaginitis 10.2 AR SHBG
45 chromosomal triplication 10.2 AFP CGA CGB3
46 sertoli-leydig cell tumor 10.2 AFP INSL3
47 androgen insensitivity, partial 10.2 AR SHBG
48 pseudovaginal perineoscrotal hypospadias 10.2 AR CGA
49 seborrheic dermatitis 10.2 CGA SHBG
50 alopecia, androgenetic, 1 10.2 AR SHBG

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to Testicular Cancer
Sources

Symptoms & Phenotypes for Testicular Cancer

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Sources

Drugs & Therapeutics for Testicular Cancer

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Drugs for Testicular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 312)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3
Testosterone enanthate Approved Phase 4,Phase 2,Phase 3 315-37-7 9416
4
Methyltestosterone Approved Phase 4,Phase 2,Phase 3 58-18-4 6010
5
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Phase 3 5949-44-0
6
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3 58-22-0 6013
7
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
9
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
10 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 interferons Phase 4,Phase 1,Phase 2
12 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
15 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
17 Interferon Inducers Phase 4,Phase 1,Phase 2
18 Androgens Phase 4,Phase 2,Phase 3
19 Testosterone 17 beta-cypionate Phase 4,Phase 2,Phase 3
20 Anabolic Agents Phase 4,Phase 2,Phase 3
21 Estradiol 3-benzoate Phase 4,Phase 3
22 Estradiol 17 beta-cypionate Phase 4,Phase 3
23 Follicle Stimulating Hormone Phase 4
24
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
25
Vinblastine Approved Phase 3 865-21-4 241903 13342
26
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
27
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
28
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
29
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
30
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
31
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
32
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 43805 6857599 5310940 9887054
33
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
34
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
35
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
36
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 50-02-2 5743
37
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 1177-87-3
38
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
39
Ofloxacin Approved Phase 3 82419-36-1 4583
40
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
41
Captopril Approved Phase 3 62571-86-2 44093
42
Ribavirin Approved Phase 3 36791-04-5 37542
43
Palivizumab Approved, Investigational Phase 3 188039-54-5
44
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
45
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
46
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
47
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
48
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
49
Acyclovir Approved Phase 3 59277-89-3 2022
50
Promethazine Approved, Investigational Phase 3 60-87-7 4927

Interventional clinical trials:

(show top 50) (show all 289)
# Name Status NCT ID Phase Drugs
1 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 Docetaxel Combined With Carboplatin Plus Anlotinib as First Line Treatment in NSCLC Not yet recruiting NCT03799601 Phase 4 Anlotinib;Docetaxel;Carboplatin
5 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
6 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
7 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
8 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
9 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
10 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
11 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
12 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
13 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
14 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
15 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
16 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
17 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
18 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
19 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
20 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
21 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
22 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
23 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
24 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
25 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
26 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
27 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
28 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
29 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
30 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
31 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
32 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
33 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
34 Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate Active, not recruiting NCT01444820 Phase 3
35 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
36 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
37 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
38 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
39 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
40 Peptide Vaccination in Treating Patients With Esophageal Cancer (STF-II) Unknown status NCT01267578 Phase 2
41 A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer Unknown status NCT00995358 Phase 2
42 Phase II Study of S-488410 to Treat Non-small Cell Lung Cancer Unknown status NCT01592617 Phase 2 S-488410
43 Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*02 Disease Controlled Advanced Non-small Cell Lung Cancer Unknown status NCT01949701 Phase 1, Phase 2
44 Decitabine Followed by Donor Lymphocyte Infusion for Patients With Relapsed Acute Myeloblastic Leukemia(AML) After Allogeneic Stem Cell Transplantation Unknown status NCT01758367 Phase 1, Phase 2 Deciatbine(DAC)
45 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
46 Promotora-based Latino Family CVD Risk Reduction Unknown status NCT01714271 Phase 2
47 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
48 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
49 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
50 Everolimus in Refractory Testicular Germ Cell Cancer Completed NCT01466231 Phase 2 Everolimus

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: testicular neoplasms

Sources

Genetic Tests for Testicular Cancer

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Genetic tests related to Testicular Cancer:

# Genetic test Affiliating Genes
1 Testicular Neoplasm 29
Sources

Anatomical Context for Testicular Cancer

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MalaCards organs/tissues related to Testicular Cancer:

41
Testis, Lymph Node, Testes, Skin, Prostate, Brain, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Testicular Cancer:

19
The Testicles
Sources

Publications for Testicular Cancer

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Articles related to Testicular Cancer:

(show top 50) (show all 1238)
# Title Authors Year
1
Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients. ( 29358504 )
2018
2
Reply to Christian D. Fankhauser, Nico C. Grossmann, Joerg Beyer, and Thomas Hermanns' Letter to the Editor re: Sophia C. Kamran, Thomas Seisen, Sarah C. Markt, et al. Contemporary treatment patterns and outcomes for clinical stage IS testicular cancer. Eur Urol 2018;73:262-70. ( 29358058 )
2018
3
Danish translation and pilot testing of the European Organization for Research and Treatment of Cancer QLQ-TC 26 (EORTC QLQ-TC26) questionnaire to assess health-related quality of life in patients with testicular cancer. ( 29914500 )
2018
4
Quantification of the Leydig cell compartment in testicular biopsies and association with biochemical Leydig cell dysfunction in testicular cancer survivors. ( 29981219 )
2018
5
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology. ( 29935977 )
2018
6
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN. ( 29902454 )
2018
7
A Review of Outcomes and Technique for the Robotic-Assisted Laparoscopic Retroperitoneal Lymph Node Dissection for Testicular Cancer. ( 29853869 )
2018
8
Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia. ( 29662825 )
2018
9
Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance. ( 29405722 )
2018
10
Testicular cancer among US men aged 50 years and older. ( 29807233 )
2018
11
Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records. ( 29970393 )
2018
12
Physical activity and risk of testicular cancer: a systematic review. ( 29444652 )
2018
13
Thromboprophylaxis and the route of administration of chemotherapy in testicular cancer patients in German-speaking countries. ( 29417289 )
2018
14
FERTILITY MANAGMENT IN TESTICULAR CANCER- The need for establishing a standardised and evidenced based patient centric pathway. ( 29920910 )
2018
15
Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report. ( 29416867 )
2018
16
Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values. ( 29963714 )
2018
17
Non-risk-adapted Surveillance for Stage I Testicular Cancer: Critical Review and Summary. ( 29338978 )
2018
18
Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer. ( 29772568 )
2018
19
Re: Multi-Institutional Assessment of Adverse Health Outcomes among North American Testicular Cancer Survivors after Modern Cisplatin-Based Chemotherapy. ( 29310185 )
2018
20
Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark. ( 29510806 )
2018
21
Long term deficiency of vitamin D in germ cell testicular cancer survivors. ( 29765521 )
2018
22
Should survivors of childhood cancer or testicular cancer be screened for androgen deficiency? ( 29920751 )
2018
23
Ophthalmological changes of the posterior segment in patients with testicular cancer in a mixed-race population of the General Hospital of Mexico. ( 29907347 )
2018
24
Re: Singh A<i>et al</i>. Robot-assisted retroperitoneal lymph node dissection: Feasibility and outcome in postchemotherapy residual mass in testicular cancer. Indian J Urol 2017;33:304-9. ( 29345697 )
2018
25
Testicular cancer: symptoms for urgent referral are identified. ( 29970611 )
2018
26
Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study. ( 29969051 )
2018
27
Hearing loss before and after cisplatin-based chemotherapy in testicular cancer survivors: a longitudinal study. ( 29384420 )
2018
28
Testicular Cancer: Epidemiology, Diagnosis, and Management. ( 29406056 )
2018
29
Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors. ( 29775128 )
2018
30
Trends in rates of inpatients treated for testicular cancer in France, 2000-2014. ( 29952145 )
2018
31
Testicular cancer in 2017: Sequencing advances understanding. ( 29256490 )
2018
32
Adenomatoid tumor of the testis mimicking malignant testicular cancer on multiparametric ultrasound. ( 29325584 )
2018
33
Dairy Consumption and Risk of Testicular Cancer: A Systematic Review. ( 29781734 )
2018
34
Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer. ( 30533236 )
2018
35
High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors. ( 29478250 )
2018
36
Editorial Comment to High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors. ( 29732674 )
2018
37
Dissecting the Evolving Risk of Relapse over Time in Surveillance for Testicular Cancer. ( 29670653 )
2018
38
Toxicities Associated with Cisplatin-Based Chemotherapy and Radiotherapy in Long-Term Testicular Cancer Survivors. ( 29670654 )
2018
39
Testicular Cancer: Diagnosis and Treatment. ( 29671528 )
2018
40
Testicular Cancer. ( 29671533 )
2018
41
Role of one, two and three doses of high-dose chemotherapy with autologous transplantation in the treatment of high-risk or relapsed testicular cancer: a systematic review. ( 29703969 )
2018
42
Recent Trends in Survival of Testicular Cancer Patients - Nation-wide Population Based Study. ( 29708357 )
2018
43
Assessment of the quality of patient-oriented information over internet on testicular cancer. ( 29716564 )
2018
44
Sexual Function in a Nationwide Cohort of 2,260 Survivors of Testicular Cancer after 17 Years of Followup. ( 29730199 )
2018
45
Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors. ( 29736007 )
2018
46
Decision analysis defining optimal management of clinical stage 1 high-risk nonseminomatous germ cell testicular cancer with lymphovascular invasion. ( 29754945 )
2018
47
Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer. ( 29761480 )
2018
48
Re: Attitudes toward Testicular Cancer and Self-Examination among Northern Irish Males. ( 29783594 )
2018
49
B-cell lymphoma 2 ovarian killer suppresses testicular cancer cell malignant behavior, but plays a role in platinum resistance. ( 29985192 )
2018
50
Brain Hyperconnectivity >10 Years After Cisplatin-Based Chemotherapy for Testicular Cancer. ( 29999422 )
2018
Sources

Variations for Testicular Cancer

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Copy number variations for Testicular Cancer from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 61546 12 1 35400000 Gain Testicular cancer
2 202070 5 76900000 102800000 Loss Testicular cancer
3 217038 7 1 158821424 Gain Testicular cancer
4 237464 8 23300000 146274826 Gain Testicular cancer
5 262544 X 37500000 154913754 Gain Testicular cancer
6 262545 X 37500000 154913754 Gain Testicular cancer
7 266960 Y 174481503 174538309 Deletion AZF Testicular cancer
Sources

Expression for Testicular Cancer

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Search GEO for disease gene expression data for Testicular Cancer.
Sources

Pathways for Testicular Cancer

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Pathways related to Testicular Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
11.5 CGA INSL3 RXFP2
2
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 10.77 CGA CGB3 CGB5
3
Nongenotropic Androgen signaling 1
10.21 AR SHBG
Sources

GO Terms for Testicular Cancer

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Biological processes related to Testicular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.46 AR CGB3 CGB5 INSL3
2 sex differentiation GO:0007548 9.32 AR TSPY1
3 female gamete generation GO:0007292 9.26 CGB3 CGB5
4 hormone-mediated signaling pathway GO:0009755 9.13 CGB3 CGB5 RXFP2
5 peptide hormone processing GO:0016486 8.8 CGA CGB3 CGB5

Molecular functions related to Testicular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 AR SHBG
2 hormone activity GO:0005179 9.13 CGA CGB3 INSL3
3 androgen binding GO:0005497 8.62 AR SHBG
Sources

Sources for Testicular Cancer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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