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MCID: TST014
MIFTS: 53

Testicular Cancer

Categories: Rare diseases, Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Testicular Cancer

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MalaCards integrated aliases for Testicular Cancer:

Name: Testicular Cancer 12 53 37 55 43 3 15
Testicular Neoplasms 44 73
Testicular Malignant Germ Cell Tumor 73
Childhood Neoplasm of the Testis 12
Pediatric Testicular Neoplasm 12
Childhood Testicular Neoplasm 73
Malignant Neoplasm of Testis 73
Carcinoma of the Testis 73
Cancer of the Testes 53
Testicular Carcinoma 55
Testicular Neoplasm 29
Neoplasm of Testis 12
Testicular Tumor 12
Testis Neoplasm 12
Testis Cancer 12

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Testicular Cancer

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MedlinePlus : 43 Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of 20 and 39. It is also more common in men who Have had abnormal testicle development Have had an undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your testicles or groin area. Doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. Most cases can be treated, especially if found early. Treatment options include surgery, radiation, and/or chemotherapy. Regular exams after treatment are important. Treatments may also cause infertility. If you may want children later on, you should consider sperm banking before treatment. NIH: National Cancer Institute

MalaCards based summary : Testicular Cancer, also known as testicular neoplasms, is related to testicular disease and testicular germ cell cancer. An important gene associated with Testicular Cancer is TDRG1 (Testis Development Related 1
The significantly reduced expression of the TDRG1 in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are G alpha (s) signalling events and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Cisplatin and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include the testicles, testis and bone.

Disease Ontology : 12 A male reproductive system cancer that is located in the testicles.

Wikipedia : 76 Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.... more...

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Related Diseases for Testicular Cancer

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Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 testicular disease 32.1 CGA INSL3
2 testicular germ cell cancer 32.1 ALPP XIST
3 cryptorchidism, unilateral or bilateral 31.9 CGA CGB5 INSL3 RXFP2 SHBG
4 testicular seminoma 31.9 CGA CGB3 TSPY1
5 teratoma 30.7 AFP CGA CGB3
6 nonseminomatous germ cell tumor 30.6 AFP CGB5
7 extragonadal germ cell cancer 30.5 AFP CGB5
8 hydrocele 30.2 AFP CGA
9 choriocarcinoma 29.6 ALPP CGA CGB3 CGB5
10 seminoma 28.0 AFP ALPP CGA CGB3 CGB5 MAGEA4
11 rete testis neoplasm 12.0
12 testicular cancer, childhood 11.9
13 resistance to bleomycine in the treatment of testicular cancer 11.9
14 testicular microlithiasis 11.3
15 embryonal carcinoma 11.0
16 rete testis adenocarcinoma 11.0
17 testicular leydig cell tumor 11.0
18 testis sarcoma 11.0
19 spermatocele 10.9
20 testicular brenner tumor 10.9
21 testis refractory cancer 10.9
22 polyembryoma 10.8 AFP CGA
23 sacrococcygeal teratoma 10.8 AFP CGA
24 malignant sertoli cell tumor 10.8 AFP CGB5
25 triploidy 10.8 AFP CGA
26 corpus luteum cyst 10.8 AFP CGB5
27 tuberculous epididymitis 10.7 AFP CGB3
28 orofaciodigital syndrome viii 10.7 AFP CGA
29 placental site trophoblastic tumor 10.7 CGB3 CGB5
30 physical disorder 10.6 AFP INSL3 RXFP2
31 mixed germ cell tumor 10.6 AFP CGA CGB3
32 seborrheic dermatitis 10.6 CGA SHBG
33 hydatidiform mole, recurrent, 1 10.5 CGA CGB3 CGB5
34 ectopic pregnancy 10.5 CGA CGB3 CGB5
35 anorchia 10.4 CGA CGB5 INSL3 RXFP2
36 testicular malignant germ cell cancer 10.4 AFP ALPP
37 complete androgen insensitivity syndrome 10.3 CGA SHBG
38 microinvasive gastric cancer 10.3 TDRG1 XIST
39 endodermal sinus tumor 10.2 AFP ALPP CGB3
40 germ cells tumors 10.1
41 prostatitis 10.0
42 turner syndrome 10.0 CGB3 SHBG TSPY1
43 aging 10.0
44 encephalitis 10.0
45 lymphoma 9.9
46 infertility 9.9
47 breast cancer 9.9
48 dermatomyositis 9.9
49 hypogonadism 9.9
50 limbic encephalitis 9.9

Graphical network of the top 20 diseases related to Testicular Cancer:



Diseases related to Testicular Cancer
Sources

Symptoms & Phenotypes for Testicular Cancer

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Sources

Drugs & Therapeutics for Testicular Cancer

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Drugs for Testicular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 307)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3
Methyltestosterone Approved Phase 4,Phase 2,Phase 3 58-18-4 6010
4
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3 58-22-0 6013
5
Testosterone enanthate Approved Phase 4,Phase 2,Phase 3 315-37-7 9416
6
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Phase 3 5949-44-0
7
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
9
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
10 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
11 interferons Phase 4,Phase 1,Phase 2
12 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
13 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Interferon Inducers Phase 4,Phase 1,Phase 2
17 Anabolic Agents Phase 4,Phase 2,Phase 3
18 Androgens Phase 4,Phase 2,Phase 3
19 Testosterone 17 beta-cypionate Phase 4,Phase 2,Phase 3
20 Estradiol 17 beta-cypionate Phase 4,Phase 3
21 Estradiol 3-benzoate Phase 4,Phase 3
22 Follicle Stimulating Hormone Phase 4
23
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
24
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
25
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
26
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
27
Vinblastine Approved Phase 3 865-21-4 13342 241903
28
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
29
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
30
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
31
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
32
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
33
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
34
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 50-02-2 5743
35
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
36
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
37
Ofloxacin Approved Phase 3 82419-36-1 4583
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
39
Captopril Approved Phase 3 62571-86-2 44093
40
Palivizumab Approved, Investigational Phase 3 188039-54-5
41
Ribavirin Approved Phase 3 36791-04-5 37542
42
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
43
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
44
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
45
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
46
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
47
Acyclovir Approved Phase 3 59277-89-3 2022
48
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
49
Promethazine Approved, Investigational Phase 3 60-87-7 4927
50
Ethinyl Estradiol Approved Phase 3 57-63-6 5991

Interventional clinical trials:

(show top 50) (show all 287)
# Name Status NCT ID Phase Drugs
1 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
5 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
6 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
8 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
9 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
10 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
11 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
12 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
13 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
14 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
15 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
16 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
17 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
18 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
19 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
20 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
21 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
22 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
23 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
24 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
25 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
26 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
27 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
28 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
29 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
30 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
31 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
32 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
33 Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate Active, not recruiting NCT01444820 Phase 3
34 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
35 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
36 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
37 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
38 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
39 Peptide Vaccination in Treating Patients With Esophageal Cancer (STF-II) Unknown status NCT01267578 Phase 2
40 A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer Unknown status NCT00995358 Phase 2
41 Sutent and Radiation as Treatment for Limited Extent Metastatic Cancer Unknown status NCT00463060 Phase 1, Phase 2 sunitinib malate (Sutent)
42 Phase II Study of S-488410 to Treat Non-small Cell Lung Cancer Unknown status NCT01592617 Phase 2 S-488410
43 Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*02 Disease Controlled Advanced Non-small Cell Lung Cancer Unknown status NCT01949701 Phase 1, Phase 2
44 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
45 Promotora-based Latino Family CVD Risk Reduction Unknown status NCT01714271 Phase 2
46 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
47 Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor Unknown status NCT02784054 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin;Thiotepa;Melphalan
48 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
49 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
50 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: testicular neoplasms

Sources

Genetic Tests for Testicular Cancer

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Genetic tests related to Testicular Cancer:

# Genetic test Affiliating Genes
1 Testicular Neoplasm 29
Sources

Anatomical Context for Testicular Cancer

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The Foundational Model of Anatomy Ontology organs/tissues related to Testicular Cancer:

19
The Testicles

MalaCards organs/tissues related to Testicular Cancer:

41
Testis, Bone, Bone Marrow, Testes, Lymph Node, Lung, T Cells
Sources

Publications for Testicular Cancer

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Articles related to Testicular Cancer:

(show top 50) (show all 849)
# Title Authors Year
1
Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients. ( 29358504 )
2018
2
Reply to Christian D. Fankhauser, Nico C. Grossmann, Joerg Beyer, and Thomas Hermanns' Letter to the Editor re: Sophia C. Kamran, Thomas Seisen, Sarah C. Markt, et al. Contemporary treatment patterns and outcomes for clinical stage IS testicular cancer. Eur Urol 2018;73:262-70. ( 29358058 )
2018
3
Danish translation and pilot testing of the European Organization for Research and Treatment of Cancer QLQ-TC 26 (EORTC QLQ-TC26) questionnaire to assess health-related quality of life in patients with testicular cancer. ( 29914500 )
2018
4
Quantification of the Leydig cell compartment in testicular biopsies and association with biochemical Leydig cell dysfunction in testicular cancer survivors. ( 29981219 )
2018
5
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology. ( 29935977 )
2018
6
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN. ( 29902454 )
2018
7
A Review of Outcomes and Technique for the Robotic-Assisted Laparoscopic Retroperitoneal Lymph Node Dissection for Testicular Cancer. ( 29853869 )
2018
8
Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia. ( 29662825 )
2018
9
Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance. ( 29405722 )
2018
10
Testicular cancer among US men aged 50 years and older. ( 29807233 )
2018
11
Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records. ( 29970393 )
2018
12
Physical activity and risk of testicular cancer: a systematic review. ( 29444652 )
2018
13
Thromboprophylaxis and the route of administration of chemotherapy in testicular cancer patients in German-speaking countries. ( 29417289 )
2018
14
FERTILITY MANAGMENT IN TESTICULAR CANCER- The need for establishing a standardised and evidenced based patient centric pathway. ( 29920910 )
2018
15
Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report. ( 29416867 )
2018
16
Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values. ( 29963714 )
2018
17
Non-risk-adapted Surveillance for Stage I Testicular Cancer: Critical Review and Summary. ( 29338978 )
2018
18
Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer. ( 29772568 )
2018
19
Re: Multi-Institutional Assessment of Adverse Health Outcomes among North American Testicular Cancer Survivors after Modern Cisplatin-Based Chemotherapy. ( 29310185 )
2018
20
Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark. ( 29510806 )
2018
21
Long term deficiency of vitamin D in germ cell testicular cancer survivors. ( 29765521 )
2018
22
An X-linked agammaglobulinemia contiguous gene syndrome with metachronous coprimary testicular cancers. ( 29307603 )
2018
23
Should survivors of childhood cancer or testicular cancer be screened for androgen deficiency? ( 29920751 )
2018
24
Ophthalmological changes of the posterior segment in patients with testicular cancer in a mixed-race population of the General Hospital of Mexico. ( 29907347 )
2018
25
Re: Singh A<i>et al</i>. Robot-assisted retroperitoneal lymph node dissection: Feasibility and outcome in postchemotherapy residual mass in testicular cancer. Indian J Urol 2017;33:304-9. ( 29345697 )
2018
26
Testicular cancer: symptoms for urgent referral are identified. ( 29970611 )
2018
27
Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study. ( 29969051 )
2018
28
Hearing loss before and after cisplatin-based chemotherapy in testicular cancer survivors: a longitudinal study. ( 29384420 )
2018
29
Testicular Cancer: Epidemiology, Diagnosis, and Management. ( 29406056 )
2018
30
Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors. ( 29775128 )
2018
31
Trends in rates of inpatients treated for testicular cancer in France, 2000-2014. ( 29952145 )
2018
32
Testicular cancer in 2017: Sequencing advances understanding. ( 29256490 )
2018
33
Adenomatoid tumor of the testis mimicking malignant testicular cancer on multiparametric ultrasound. ( 29325584 )
2018
34
Dairy Consumption and Risk of Testicular Cancer: A Systematic Review. ( 29781734 )
2018
35
Re: Attitudes toward Testicular Cancer and Self-Examination among Northern Irish Males. ( 29783594 )
2018
36
Management of testicular cancer: NYU case of the month, March 2017. ( 28522933 )
2017
37
Testicular cancer: Origin and evolution of TGCTs. ( 27922034 )
2017
38
Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy. ( 28240972 )
2017
39
Stomach Cancer Following Hodgkin Lymphoma, Testicular Cancer and Cervical Cancer: A Pooled Analysis of Three International Studies with a Focus on Radiation Effects. ( 28118119 )
2017
40
New SNPs from Testicular Cancer GWAS. ( 28687564 )
2017
41
Environmental Factors Affecting Growth and Occurrence of Testicular Cancer in Childhood: An Overview of the Current Epidemiological Evidence. ( 28067779 )
2017
42
Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer. ( 28448657 )
2017
43
Evaluation of sperm DNA quality in men presenting with testicular cancer and lymphoma using alkaline and neutral Comet assays. ( 28950441 )
2017
44
A randomized double-blind study of testosterone replacement therapy or placebo in testicular cancer survivors with mild Leydig cell insufficiency (Einstein-intervention). ( 28673265 )
2017
45
Metachronous Testicular Cancer After Orchiectomy: A Rare Case. ( 29333356 )
2017
46
Cancer-Related Worry and Physical Well-Being in the Context of Perceived Stress in Young Adults with Testicular Cancer. ( 28128672 )
2017
47
Adjuvant chemotherapy and follow-up for recurrences in localized testicular cancer. ( 28481147 )
2017
48
Assessment of Volumetric versus Manual Measurement in Disseminated Testicular Cancer; No Difference in Assessment between Non-Radiologists and Genitourinary Radiologist. ( 28081195 )
2017
49
Fertility preservation of patients with testicular cancer. ( 29259474 )
2017
50
Testicular cancer from diagnosis to epigenetic factors. ( 29262668 )
2017
Sources

Variations for Testicular Cancer

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Copy number variations for Testicular Cancer from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 61546 12 1 35400000 Gain Testicular cancer
2 202070 5 76900000 102800000 Loss Testicular cancer
3 217038 7 1 158821424 Gain Testicular cancer
4 237464 8 23300000 146274826 Gain Testicular cancer
5 262544 X 37500000 154913754 Gain Testicular cancer
6 262545 X 37500000 154913754 Gain Testicular cancer
7 266960 Y 174481503 174538309 Deletion AZF Testicular cancer
Sources

Expression for Testicular Cancer

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Search GEO for disease gene expression data for Testicular Cancer.
Sources

Pathways for Testicular Cancer

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Pathways related to Testicular Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
11.3 CGA INSL3 RXFP2
2
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 10.77 CGA CGB3 CGB5
Sources

GO Terms for Testicular Cancer

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Biological processes related to Testicular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.26 CGA CGB3 CGB5 INSL3
2 female gamete generation GO:0007292 9.16 CGB3 CGB5
3 peptide hormone processing GO:0016486 8.8 CGA CGB3 CGB5

Molecular functions related to Testicular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CGA CGB3 INSL3
Sources

Sources for Testicular Cancer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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