Testicular Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TST014 MIFTS: 52	Testicular Cancer Categories: Cancer diseases, Endocrine diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Testicular Cancer

MalaCards integrated aliases for Testicular Cancer:

Name: Testicular Cancer ¹¹ ⁵³ ⁵ ⁴¹ ¹⁴ ⁷⁵ ³³

Malignant Neoplasm of Testis ⁷¹ ³¹

Testicular Carcinoma ⁵³ ¹⁶

Testicular Neoplasms ⁴³ ⁷¹

Testis Cancer ¹¹ ³³

Malignant Neoplasm of Testis, Unspecified ³³

Testicular Malignant Germ Cell Tumor ⁷¹

Primary Malignant Neoplasm of Testis ³³

Malignant Neoplasm of Testis, Nos ³³

Childhood Neoplasm of the Testis ¹¹

Pediatric Testicular Neoplasm ¹¹

Childhood Testicular Neoplasm ⁷¹

Malignant Tumour of Testis ³³

Carcinoma of the Testis ⁷¹

Testicular Neoplasm ¹⁶

Neoplasm of Testis ¹¹

Testicular Tumors ¹⁴

Testicular Tumor ¹¹

Cancer of Testis ³³

Testis Neoplasm ¹¹

Testicle Cancer ³³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Neoplasms

Malignant neoplasms of male genital organs

Malignant neoplasm of testis

Malignant neoplasm: Testis, unspecified

ICD11: ³³

Neoplasms

Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues

Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues

Malignant neoplasms of male genital organs

Malignant neoplasms of testis

Malignant neoplasms of testis, unspecified

Other specified malignant neoplasms of testis

External Ids:

Disease Ontology ¹¹ DOID:2998

ICD9CM ³⁴ 186

MeSH ⁴³ D013736

NCIt ⁴⁹ C3404 C5053 C7251

SNOMED-CT ⁶⁸ 126900000 94087009

ICD10 ³¹ C62 C62.9

EFO ¹⁶ EFO_0004281 EFO_0005088

ICD11 ³³ 673566475 673566475/other 673566475/unspecified

UMLS ⁷¹ C0039590 C0153594 C0677483 more

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Summaries for Testicular Cancer

MedlinePlus: ⁴¹ Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of 20 and 39. It is also more common in men who: Have had abnormal testicle development Have had an undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your testicles or groin area. Doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. Most cases can be treated, especially if found early. Treatment options include surgery, radiation, and/or chemotherapy. Regular exams after treatment are important. Treatments may also cause infertility. If you may want children later on, you should consider sperm banking before treatment. NIH: National Cancer Institute

MalaCards based summary: Testicular Cancer, also known as malignant neoplasm of testis, is related to cryptorchidism, unilateral or bilateral and testicular germ cell cancer. An important gene associated with Testicular Cancer is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways is Relaxin receptors. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include testicles, testis and lymph node, and related phenotypes are neoplasm and endocrine/exocrine gland

Disease Ontology: ¹¹ A male reproductive system cancer that is located in the testicles.

Wikipedia: ⁷⁵ Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.... more...

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Related Diseases for Testicular Cancer

Diseases related to Testicular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 682)

#	Related Disease	Score	Top Affiliating Genes
1	cryptorchidism, unilateral or bilateral	32.5	SHBG RXFP2 INSL3 CGB5 ALPP AFP
2	testicular germ cell cancer	32.4	XIST STK11 MAGEA4 INSL3 FGFR3 BCL10
3	testicular germ cell tumor	32.3	STK11 FGFR3 BCL10
4	testicular disease	32.3	SHBG RXFP2 MAGEA4 INSL3 ERCC1 AFP
5	spermatocytoma	32.2	MAGEA4 FGFR3 AFP
6	seminoma	32.2	TDRG1 MAGEA4 CGB5 ALPP AFP
7	germ cell tumor	32.0	STK11 FGFR3
8	endodermal sinus tumor	31.4	CGB5 ALPP AFP
9	inguinal hernia	31.2	RXFP2 INSL3 AFP
10	extragonadal germ cell cancer	30.9	CGB5 AFP
11	androgen insensitivity syndrome	30.8	SHBG RXFP2 INSL3
12	male infertility	30.8	SHBG RXFP2 INSL3 CCNA1
13	testicular torsion	30.7	SHBG RXFP2 INSL3 AFP
14	gastric cancer	30.7	XIST TDRG1 STK11 ERCC1 DNMT1 CTAG1B
15	hypogonadotropic hypogonadism	30.6	XIST SHBG RXFP2 INSL3
16	germinoma	30.5	CGB5 ALPP AFP
17	disorder of sexual development	30.3	SHBG RXFP2 INSL3 AFP
18	sertoli-leydig cell tumor	30.3	INSL3 ALPP AFP
19	gonadoblastoma	30.3	CGB5 ALPP AFP
20	adenomatoid tumor	30.3	CGB5 AFP
21	premature menopause	29.8	SHBG INSL3 ERCC1 AFP
22	rete testis neoplasm	11.3
23	embryonal carcinoma	11.2
24	testicular leydig cell tumor	11.2
25	testis sarcoma	11.1
26	rete testis adenocarcinoma	11.1
27	testis refractory cancer	11.0
28	isolated splenogonadal fusion	11.0
29	persistent mullerian duct syndrome	11.0
30	spermatocele	11.0
31	testicular brenner tumor	11.0
32	germ cell cancer	10.9
33	teratoma	10.9
34	nonseminomatous germ cell tumor	10.8
35	pigmented villonodular synovitis	10.7
36	tenosynovial giant cell tumor	10.7
37	mature teratoma	10.6
38	testicular germ cell tumor 1	10.6
39	infertility	10.6
40	hypogonadism	10.6
41	choriocarcinoma	10.5
42	azoospermia	10.5
43	impotence	10.5
44	testicular seminoma	10.5
45	testicular microlithiasis	10.5
46	corpus luteum cyst	10.4	CGB5 AFP
47	microinvasive gastric cancer	10.4	XIST TDRG1 AFP
48	hepatic tuberculosis	10.4	ALPP AFP
49	lymphoma, hodgkin, classic	10.4
50	raynaud disease	10.4

Graphical network of the top 20 diseases related to Testicular Cancer:

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Symptoms & Phenotypes for Testicular Cancer

MGI Mouse Phenotypes related to Testicular Cancer:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.7	AFP DNMT1 ERCC1 FGFR3 IGF2BP2 RXFP2
2	endocrine/exocrine gland	MP:0005379	9.61	AFP BCL10 CCNA1 CGB5 ERCC1 INSL3
3	reproductive system	MP:0005389	9.32	AFP CCNA1 CGB5 DNMT1 ERCC1 FGFR3

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Drugs & Therapeutics for Testicular Cancer

Drugs for Testicular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cyclophosphamide

Approved, Investigational

Phase 3

50-18-0, 6055-19-2

2907

Lenograstim

Approved, Investigational

Phase 3

135968-09-1

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 3

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3

50-02-2

3003 5743

Ondansetron

Approved, Withdrawn

Phase 3

99614-02-5

4595

Fosaprepitant

Approved

Phase 3

172673-20-0

219090 135413538

Olanzapine

Approved, Investigational

Phase 3

132539-06-1

135398745 4585

Bleomycin

Approved, Investigational

Phase 3

9041-93-4, 11056-06-7

5360373

Etoposide

Approved

Phase 3

33419-42-0

36462

Oxaliplatin

Approved, Investigational

Phase 3

61825-94-3

43805 11947679 6857599

Cisplatin

Approved

Phase 3

15663-27-1

2767 5702198 441203

Paclitaxel

Approved, Vet_approved

Phase 3

33069-62-4

36314

Ifosfamide

Approved

Phase 3

3778-73-2

3690

Vinblastine

Approved

Phase 3

865-21-4

241903 13342

Palifosfamide

Investigational

Phase 3

31645-39-3

100427

Hormones

Phase 3

Immunosuppressive Agents

Phase 3

Immunologic Factors

Phase 3

Calcium, Dietary

Phase 3

Antirheumatic Agents

Phase 3

Neurotransmitter Agents

Phase 3

Antipsychotic Agents

Phase 3

Psychotropic Drugs

Phase 3

Antiemetics

Phase 3

Serotonin Uptake Inhibitors

Phase 3

Gastrointestinal Agents

Phase 3

Anti-Bacterial Agents

Phase 3

Etoposide phosphate

Phase 3

16760419

Antibiotics, Antitubercular

Phase 3

Albumin-Bound Paclitaxel

Phase 3

Antimitotic Agents

Phase 3

Tubulin Modulators

Phase 3

Alkylating Agents

Phase 3

Antineoplastic Agents, Alkylating

Phase 3

Calcium

Nutraceutical

Phase 3

7440-70-2

271

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

Sorafenib

Approved, Investigational

Phase 2

284461-73-0

216239

Magnesium sulfate

Approved, Investigational, Vet_approved

Phase 1, Phase 2

7487-88-9

Ranitidine

Approved, Withdrawn

Phase 1, Phase 2

66357-59-3, 82530-72-1, 66357-35-5

3001055 5039

Furosemide

Approved, Vet_approved

Phase 1, Phase 2

54-31-9

3440

Chlorpheniramine

Approved

Phase 1, Phase 2

113-92-8, 132-22-9

2725

Sorbitol

Approved, Investigational

Phase 1, Phase 2

69-65-8, 50-70-4

453 6251 5780

Pancrelipase

Approved, Investigational

Phase 2

53608-75-6

8519

Durvalumab

Approved, Investigational

Phase 1, Phase 2

1428935-60-7

Tremelimumab

Approved, Investigational

Phase 1, Phase 2

745013-59-6

Lorazepam

Approved

Phase 2

846-49-1

3958

Levoleucovorin

Approved, Experimental, Investigational

Phase 2

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Fluorouracil

Approved

Phase 2

51-21-8

3385

Everolimus

Approved

Phase 2

159351-69-6

70789204 6442177

Epirubicin

Approved

Phase 2

56420-45-2

41867

Interventional clinical trials:

(show top 50) (show all 137)

#	Name	Status	NCT ID	Phase	Drugs
1	Taste and Smell Changes in Testicular Cancer Patients Treated With Cisplatin Based Chemotherapy	Completed	NCT01641172	Phase 4
2	A Single Group Trial Evaluating One Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Tumours of the Testis (NSGCTT)	Unknown status	NCT01726374	Phase 3	BEP(500)
3	A Randomized Double-blind Study of Testosterone Replacement Therapy or Placebo in Testicular Cancer Survivors With Mild Leydig Cell Insufficiency (Einstein-intervention)	Completed	NCT02991209	Phase 2, Phase 3	Testosterone;Placebos
4	A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors	Completed	NCT00053352	Phase 3	cisplatin;etoposide
5	RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS	Completed	NCT00002596	Phase 3	carboplatin;cisplatin;cyclophosphamide;etoposide
6	A Randomized Double Blinded Trial of Topical Caphosol to Prevent Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation	Completed	NCT01305200	Phase 3	supersaturated calcium phosphate rinse
7	A Randomized Phase III Study Comparing One Course of Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) and One Course of Carboplatin AUC7 in Clinical Stage I Seminomatous Testicular Cancer	Recruiting	NCT02341989	Phase 3	Bleomycin Etoposide and Cisplatin;Carboplatin
8	A Phase III Randomized, Double-blind, Placebo-controlled, Cross-over Study to Evaluate Olanzapine Combined With Fosaprepitant, Ondansetron, and Dexamethasone for Preventing Nausea and Vomiting in Patients With Testicular Cancer Receiving 5-day Cisplatin Combination Chemotherapy	Recruiting	NCT05244577	Phase 3	Olanzapine Tablets;Placebo
9	A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors	Active, not recruiting	NCT00104676	Phase 3	cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
10	A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors	Terminated	NCT00072215	Phase 3	cisplatin;ifosfamide;paclitaxel;vinblastine
11	A Biobehavioral Intervention for Young Men With Testicular Cancer: A Pilot Study	Unknown status	NCT04150848	Phase 2
12	Sorafenib (NEXAVAR) Monotherapy in Patients With Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy	Unknown status	NCT00772694	Phase 2	sorafenib
13	Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer	Unknown status	NCT00551122	Phase 1, Phase 2	cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14	A Prospective Phase II Trial of Cabazitaxel in Male Patients With Chemotherapy Pre-treated Metastatic Nonseminomatous Germ-cell Tumors	Unknown status	NCT02115165	Phase 2	Cabazitaxel
15	A Prospective Multicenter Phase II Trial of Gemcitabine, Cisplatin, and Ifosfamide (GIP) in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors (NSGCT) and a Predicted Favorable Prognosis	Unknown status	NCT00127049	Phase 2	gemcitabine, ifosfamide, cisplatin, G-CSF
16	Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment	Unknown status	NCT01172912	Phase 2	carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
17	A Phase II Clinical Study to Evaluate the Safety and Efficacy of FalateScan (Technetium Tc 99m EC20) in Patients With Known Suspected Recurrent or Metastatic Cancer From a Solid Tumor	Completed	NCT01684098	Phase 2	Tc 99m EC20
18	A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab (MEDI4736) Plus the Toll-like Receptor Agonist Poly-ICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers	Completed	NCT02643303	Phase 1, Phase 2	Durvalumab;Tremelimumab;Poly-ICLC
19	Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases	Completed	NCT00587964	Phase 2
20	A Phase II Study of Gemcitabine, Oxaliplatin, and Paclitaxel in Patients With Refractory Germ Cell Carcinoma	Completed	NCT00183820	Phase 2	paclitaxel, gemcitabine, and oxaliplatin
21	A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors	Completed	NCT00957905	Phase 2	Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
22	A Single Arm, Open-label Multicenter Phase II Trial of Everolimus in Patients With Relapsed/Refractory Germ Cell Cancer	Completed	NCT01242631	Phase 2	Everolimus
23	Phase II Study of Gemcitabine, Carboplatin and VELIPARIB (ABT-888) in Refractory Testicular Germ Cell Cancer	Completed	NCT02860819	Phase 2	Veliparib;Gemcitabine;Carboplatin
24	Sequential High-Dose Chemotherapy Combining Two Mobilization and Cyto-Reductive Treatments Followed by Three High-Dose Chemotherapy Regimens Supported by Autologous Stem Cell Transplantation	Completed	NCT00231582	Phase 2	epirubicin;paclitaxel;etoposide;ifosfamide;carboplatin
25	Phase II Study of Avelumab in Multiple Relapsed/Refractory Testicular Germ Cell Cancer.	Completed	NCT03403777	Phase 2	Avelumab
26	A Phase II Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Cancers of Low Incidence	Completed	NCT00123773	Phase 2
27	Randomized Phase 2 Study of Conventional Dose Chemotherapy Versus High Dose Sequential Chemotherapy as First-line Therapy for Metastatic Poor Prognosis Germ Cell Tumors	Completed	NCT02161692	Phase 2	Cyclophosphamide;Etoposide;Cisplatin;Bleomycin;Carboplatin
28	Prevention of DMSO-Related Nausea and Vomiting by Prophylactic Administration of Ondansetron for Patients Receiving Autologous Cryopreserved Peripheral Blood Stem Cells	Completed	NCT00795769	Phase 2	ondansetron
29	Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor	Completed	NCT00453232	Phase 2	cisplatin;etoposide
30	A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors	Completed	NCT00453310	Phase 2	sunitinib malate
31	Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin	Completed	NCT00467051	Phase 2	Carboplatin;Ifosfamide;Paclitaxel
32	High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study	Completed	NCT00002943	Phase 2	carboplatin;cyclophosphamide;etoposide
33	A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL	Completed	NCT00070096	Phase 2	ixabepilone
34	Phase II Trial of Temozolomide in Patients With Cisplatin-Refractory Germ Cell Tumors	Completed	NCT00006043	Phase 2	temozolomide
35	A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors	Completed	NCT00004077	Phase 2	cisplatin;ifosfamide;paclitaxel
36	Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors	Completed	NCT00301782	Phase 2	carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
37	Phase II Study of Paclitaxel Plus Gemcitabine in Refractory Germ Cell Tumors	Completed	NCT00003518	Phase 2	gemcitabine hydrochloride;paclitaxel
38	Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer	Completed	NCT01037790	Phase 2	PD-0332991
39	A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors	Completed	NCT00091182	Phase 2	oxaliplatin
40	Phase II Study of Everolimus in Refractory Testicular Germ Cell Cancer.	Completed	NCT01466231	Phase 2	Everolimus
41	Short-term Testosterone Replacement in Testicular Cancer Survivors to Treat Overweight and Improve Cardiometabolic Risk: A Pilot Study	Recruiting	NCT03339635	Phase 2	Androgel (Testosterone gel);Placebo gel
42	Phase 2 Study Cabazitaxel as Salvage Treatment for Cisplatin-resistant Germ Cell	Recruiting	NCT02478502	Phase 2	cabazitaxel
43	Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma. A Multicenter, Open Label Phase II Trial With Two Cohorts	Recruiting	NCT03937843	Phase 2	Carboplatin;Cisplatin;Etoposide
44	Reduced-dose Radiotherapy Following High-dose Chemotherapy and Autologous Stem Cell Transplantation in Patients With Central Nervous System Non-germinomatous Germ Cell Tumors	Recruiting	NCT02784054	Phase 2	Carboplatin;Etoposide;Cyclophosphamide;Bleomycin;Thiotepa;Melphalan
45	Phase I/IIa Trial to Evaluate Safety and Preliminary Efficacy of CLDN6-CAR-NK in Patients With CLDN6-positive Advanced Solid Tumors	Recruiting	NCT05410717	Phase 1, Phase 2
46	High-dose Chemotherapy for Poor-Prognosis Relapsed Germ-Cell Tumors	Active, not recruiting	NCT00936936	Phase 2	Gemcitabine;Docetaxel;Melphalan;Carboplatin;Mesna;Ifosfamide;Etoposide
47	Administration of T Lymphocytes Expressing the CD30 Chimeric Antigen Receptor (CAR) for Patients With CD30+ Nonseminomatous Germ Cell Tumors (NSGCT)	Not yet recruiting	NCT05634785	Phase 2	Cyclophosphamid;Fludarabine
48	Phase II Trial of Paclitaxel, Gemcitabine and Cisplatin in Patients With Relapsing Germ Cell Cancer	Terminated	NCT00531687	Phase 2	Paclitaxel;Cisplatin;Gemcitabine
49	A Multicenter Phase II Study of Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors	Terminated	NCT02689219	Phase 2	Brentuximab Vedotin
50	A Phase II Single-Arm Multi-Center Trial Evaluating the Efficacy of Pembrolizumab in the Treatment of Subjects With Incurable Platinum-Refractory Germ Cell Tumors: Hoosier Cancer Research Network GU14-206	Terminated	NCT02499952	Phase 2	Pembrolizumab

Search NIH Clinical Center for Testicular Cancer

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Chlorambucil

Cisplatin

CISPLATIN PWDR

Cyclophosphamide

Etoposide

etoposide phosphate

Ifosfamide

Methotrexate

Methotrexate Sodium

Vinblastine

Vinblastine Sulfate

Cochrane evidence based reviews: testicular neoplasms

Sources

Genetic Tests for Testicular Cancer

Sources

Anatomical Context for Testicular Cancer

Organs/tissues related to Testicular Cancer:

FMA: Testicles

MalaCards : Testis, Lymph Node, Testes, Skin, Bone Marrow, Bone, Skeletal Muscle

Sources

Publications for Testicular Cancer

Articles related to Testicular Cancer:

(show top 50) (show all 11234)

#	Title	Authors	PMID	Year
1	Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. ⁵³ ⁶² ⁵	Ylikorkala A...Aaltonen LA	9887330	1999
2	Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. ⁵³ ⁶² ⁵	Avizienyte E...Aaltonen LA	9605748	1998
3	Point mutations and deletions of the Bcl10 gene in solid tumors and malignant lymphomas. ⁵	Lee SH...Yoo NJ	10582682	1999
4	Long-term results of postoperative unsuspected small cell lung cancer on real-world data. ⁴¹	Guo J...Liang C	36461029	2022
5	Surveillance Strategy after Curative Resection for Oesophageal Squamous Cell Cancer Using the Hazard Function. ⁴¹	Kanematsu K...Daiko H	36457081	2022
6	Long-Term Oncologic Outcome of Breast Cancer in Southern Iran: A Retrospective Cohort Study. ⁴¹	Omidvari A...Mohammadianpanah M	36444601	2022
7	Seminal expression of NY-ESO-1 and MAGE-A4 as markers for the testicular cancer. ⁵³ ⁶²	Satie AP...Jegou B	19207618	2009
8	Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. ⁵³ ⁶²	Peterson M...Foster R	19493258	2009
9	Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones. ⁵³ ⁶²	de Bruin D...Gietema JA	18440530	2009
10	Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer. ⁵³ ⁶²	Lempiainen A...Hotakainen K	18787014	2008
11	[Place of serum HCG assay in the follow-up of non-HCG-secreting testicular seminomas]. ⁵³ ⁶²	Djeffal C...Petit J	18971108	2008
12	False tumor marker surge evoked by peripheral blood stem cell transplantation. ⁵³ ⁶²	Inoue M...Kihara K	18515737	2008
13	The use of tumor markers in testis cancer in the United States: a potential quality issue. ⁵³ ⁶²	Gilbert SM...Hollenbeck BK	18312934	2008
14	Late relapse of testicular cancer 21 years after first complete remission: a case report. ⁵³ ⁶²	Kohei N...Ogawa O	18260359	2008
15	DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer. ⁵³ ⁶²	Omisanjo OA...Steger K	16960727	2007
16	Immunostaining for placental alkaline phosphatase on fine-needle aspiration specimens to detect noninvasive testicular cancer: a prospective evaluation in cryptorchid men. ⁵³ ⁶²	Dieckmann KP...Loy V	17227503	2007
17	[Significance of thcg assay in the management of testicular cancer--the possibility of a standard assay in testicular cancer as an alternative to FbetahCG assay]. ⁵³ ⁶²	Takizawa A...Kubota Y	17302291	2007
18	Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization. ⁵³ ⁶²	Ferlin A...Foresta C	16687567	2006
19	Y chromosome instability in testicular cancer. ⁵³ ⁶²	Bianchi NO...Pavicic W	16483836	2006
20	Immunostaining for placental alkaline phosphatase on fine-needle aspiration specimens to detect noninvasive testicular cancer: a prospective evaluation in cryptorchid men. ⁵³ ⁶²	Tavolini IM...Foresta C	16643476	2006
21	[Two cases of testicular cancer with low human chorionic gonadotropin (hCG) levels after treatment]. ⁵³ ⁶²	Takizawa A...Osada Y	16119815	2005
22	Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. ⁵³ ⁶²	Laska MJ...Vogel U	15885892	2005
23	Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis. ⁵³ ⁶²	Bay K...Andersson AM	15755855	2005
24	Human tissue kallikrein gene family: applications in cancer. ⁵³ ⁶²	Obiezu CV...Diamandis EP	15911097	2005
25	Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis. ⁵³ ⁶²	Manton KJ...Antalis TM	15685234	2005
26	Ethnic variation in the prevalence of AZF deletions in testicular cancer. ⁵³ ⁶²	Richard SM...Pavicic W	15450403	2004
27	Selecting an appropriate hCG test for managing gestational trophoblastic disease and cancer. ⁵³ ⁶²	Cole LA...Sutton JM	15305826	2004
28	Clinical parameters that predict histology of postchemotherapy retroperitoneal lymph node mass in testicular cancer. ⁵³ ⁶²	Onozawa M...Akaza H	15242364	2004
29	[Significance of current bio- and molecular-markers in urological cancers]. ⁵³ ⁶²	Shimazui T...Akaza H	15272577	2004
30	XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. ⁵³ ⁶²	Kawakami T...Okada Y	14723995	2004
31	Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. ⁵³ ⁶²	Nony P...Billaud M	14668798	2003
32	[Paraneoplastic hyperthyroidism in a patient with metastasizing teratocarcinoma and excessively high HCG]. ⁵³ ⁶²	Berdjis N...Wirth M	14579189	2003
33	E- and A-type cyclins as markers for cancer diagnosis and prognosis. ⁵³ ⁶²	Yasmeen A...Muller-Tidow C	14510182	2003
34	No AZF deletion in 160 patients with testicular germ cell neoplasia. ⁵³ ⁶²	Frydelund-Larsen L...Rajpert-De Meyts E	12900510	2003
35	[Endocrine profiles and gonadotropin response to Gn-RH of men with testicular cancer]. ⁵³ ⁶²	Watanabe M...Yoshida H	12910930	2003
36	Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. ⁵³ ⁶²	Schreiber L...Maymon BB	12598912	2003
37	Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer. ⁵³ ⁶²	Smith-Sorensen B...Lothe RA	12483540	2002
38	alpha-Catenin expression pattern and DNA image-analysis cytometry have no additional value over primary histology in clinical stage I nonseminomatous testicular cancer. ⁵³ ⁶²	Spermon JR...Van Moorselaar RJ	11856111	2002
39	[Lung resistance protein analysis in testicular cancer]. ⁵³ ⁶²	Mandoky L...Bak M	12563357	2002
40	[A prospect of molecular biology in the field of urologic oncology: mechanisms of carcinogenesis or tumor development in testicular cancer]. ⁵³ ⁶²	Nonomura N...Okuyama A	11771175	2001
41	PET and PLAP in suspected testicular cancer relapse: beware sarcoidosis. ⁵³ ⁶²	Karapetis CS...Harper PG	11762823	2001
42	Establishment of a testicular carcinoma cell line producing alpha-fetoprotein. ⁵³ ⁶²	Ueno M...Murai M	11678760	2001
43	Organization and chromosomal localization of the murine Testisin gene encoding a serine protease temporally expressed during spermatogenesis. ⁵³ ⁶²	Scarman AL...Antalis TM	11231276	2001
44	A new highly specific monoclonal antibody against placental alkaline phosphatase: a potential marker for the early detection of testis tumour. ⁵³ ⁶²	Nouri AM...Dabare AA	11069419	2000
45	Localization, expression and genomic structure of the gene encoding the human serine protease testisin. ⁵³ ⁶²	Hooper JD...Antalis TM	11004480	2000
46	Validation of 125I-hCG as a marker for elimination of hCG and stability of 125I-hCG after in vivo injection in humans. ⁵³ ⁶²	Christensen TB...von der Maase H	10408403	1999
47	125I-labelled human chorionic gonadotrophin (hCG) as an elimination marker in the evaluation of hCG decline during chemotherapy in patients with testicular cancer. ⁵³ ⁶²	Christensen TB...von der Maase H	10408402	1999
48	Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. ⁵³ ⁶²	Petersen PM...Giwercman A	10071288	1999
49	Standardization and potential use of HPLC for detection of cellular placental alkaline phosphatase using established tumour cell lines and fresh tumour biopsies. ⁵³ ⁶²	Torabi-Pour N...Oliver RT	10743701	1999
50	Gonadotrophin secretion patterns in testicular cancer patients with greatly increased human chorionic gonadotrophin serum concentrations. ⁵³ ⁶²	Madersbacher S...Berger P	9834462	1998

Sources

Genes for Testicular Cancer

Genes related to Testicular Cancer (3 elite genes):

(show top 50) (show all 88)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	STK11	Serine/Threonine Kinase 11	Protein Coding	448.67	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Functions (show sections)	9605748 9887330 14668798
2	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	405.22	Pathogenic ⁵ DISEASES inferred ¹⁴
3	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	403.57	Pathogenic ⁵ DISEASES inferred ¹⁴	10582682
4	TDRG1	Testis Development Related 1	RNA Gene	155	Experimental evidence: Expression ³⁷ DISEASES inferred ¹⁴	21243750
5	BOK-AS1	BOK Antisense RNA 1	RNA Gene	150	Experimental evidence: Regulation ³⁷	19287972
6	INSL3	Insulin Like 3	Protein Coding	31.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	16687567 15755855
7	AFP	Alpha Fetoprotein	Protein Coding	29.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9436034 11678760 7680279 (more) 15242364 18260359 1708922 12499420 9258097 18312934 15272577 9823978 19493258 7525293 8318413
8	MAGEA4	MAGE Family Member A4	Protein Coding	23.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16467087 14991579 19207618 (more) 12875607 12681059 16489695
9	CTAG1B	Cancer/Testis Antigen 1B	Protein Coding	23.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18982744 18396787 16432832 (more) 17625806 11668506 15118836 15516106 16003730 17986662 18729190 20067767 11265773 11351307 12574209 14991579 18166319 18311489 19030781 19212631 20044626 11300471 16160911 15069548 12681059 18809922 15515159 15838382 14555509 20518717 19193472 20381863 18093940 16773077 17208940 17294444 16551878 16467087 10969798 10901371 20208059 15026363 19207618 9560255 11397121 12384295 14503968 15240519 16489695
10	ALPP	Alkaline Phosphatase, Placental	Protein Coding	22.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12598912 16643476 10359511 (more) 10743701 1965543 11762823 11069419 8394948 17227503
11	ACP4	Acid Phosphatase 4	Protein Coding	20.12	DISEASES inferred ¹⁴ GeneCards inferred via : Summaries Expressions (show sections)
12	PAGE4	PAGE Family Member 4	Protein Coding	19.29	DISEASES inferred ¹⁴ GeneCards inferred via : Summaries Expressions (show sections)
13	CGB5	Chorionic Gonadotropin Subunit Beta 5	Protein Coding	18.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7923124 18787014 12910930 (more) 16119815 1372196 1381136 7690985 1282774 7527309 15305826 15755855 17302291 8312691 15205339 18515737
14	RXFP2	Relaxin Family Peptide Receptor 2	Protein Coding	18.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	16687567
15	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	16.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15885892
16	XIST	X Inactive Specific Transcript	RNA Gene	16.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14723995
17	SHBG	Sex Hormone Binding Globulin	Protein Coding	16.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10071288 2249122
18	CCNA1	Cyclin A1	Protein Coding	15.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14510182
19	IGF2BP2	Insulin Like Growth Factor 2 MRNA Binding Protein 2	Protein Coding	15.28	GeneCards inferred via : Publications Expressions (show sections)
20	DNMT1	DNA Methyltransferase 1	Protein Coding	14.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16960727
21	SSX2	SSX Family Member 2	Protein Coding	14.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10749136 14611804 16224274 (more) 11823502 15781633 9639388 9378559 12521124 18295890
22	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	14.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15885892
23	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	14.19	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9834462 14579189 1689221 (more) 10071288 18407171 10408402 8432011 15272577 18971108 9258097 10408403 9823978 8318413
24	MAGEA1	MAGE Family Member A1	Protein Coding	14.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11668506 11953832 16467087 (more) 17208940 19595265 12681059
25	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	13.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12483540
26	PRSS21	Serine Protease 21	Protein Coding	13.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15685234 11004480 11231276
27	SYCP1	Synaptonemal Complex Protein 1	Protein Coding	13.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14991579
28	MVP	Major Vault Protein	Protein Coding	13.13	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12563357 8774142
29	MAGEA3	MAGE Family Member A3	Protein Coding	13.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14991579 12855658 12681059
30	AZF1	Azoospermia Factor 1	Genetic Locus	12.74	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16483836 15450403 12900510
31	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	12.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18440530
32	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	11.83	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
33	SPA17	Sperm Autoantigenic Protein 17	Protein Coding	11.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18779750 20485677 17336323 (more) 12213290
34	HDAC1	Histone Deacetylase 1	Protein Coding	11.11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
35	CTCFL	CCCTC-Binding Factor Like	Protein Coding	11.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17363524
36	TSKS	Testis Specific Serine Kinase Substrate	Protein Coding	10.86	DISEASES inferred ¹⁴ GeneCards inferred via : Summaries (show sections)
37	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	10.28	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
38	MIR371A	MicroRNA 371a	RNA Gene	9.98	DISEASES inferred ¹⁴ ¹⁴
39	PPP1R13L	Protein Phosphatase 1 Regulatory Subunit 13 Like	Protein Coding	9.89	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
40	TRO	Trophinin	Protein Coding	9.74	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15205339
41	MLANA	Melan-A	Protein Coding	9.38	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10842196 16467087
42	TSPY1	Testis Specific Protein Y-Linked 1	Protein Coding	9.18	Novoseek inferred ⁵³	8923009
43	MIR199A1	MicroRNA 199a-1	RNA Gene	9	DISEASES inferred ¹⁴ ¹⁴
44	KLK6	Kallikrein Related Peptidase 6	Protein Coding	8.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15911097
45	CTNNA1	Catenin Alpha 1	Protein Coding	8.54	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11856111
46	H2AC18	H2A Clustered Histone 18	Protein Coding	8.53	DISEASES inferred ¹⁴ ¹⁴
47	MIR372	MicroRNA 372	RNA Gene	8.46	DISEASES inferred ¹⁴ ¹⁴
48	MIR373	MicroRNA 373	RNA Gene	8.45	DISEASES inferred ¹⁴ ¹⁴
49	CCNA2	Cyclin A2	Protein Coding	7.41	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11302861
50	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11771175

Sources

Variations for Testicular Cancer

ClinVar genetic disease variations for Testicular Cancer:

⁵ (show all 30)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	STK11	NM_000455.5(STK11):c.488G>A (p.Gly163Asp)	SNV	Pathogenic	7448	rs137853078	GRCh37: 19:1220395-1220395 GRCh38: 19:1220396-1220396
2	FGFR3	NM_000142.5(FGFR3):c.742C>T (p.Arg248Cys)	SNV	Pathogenic	16332	rs121913482	GRCh37: 4:1803564-1803564 GRCh38: 4:1801837-1801837
3	FGFR3	NM_000142.5(FGFR3):c.746C>G (p.Ser249Cys)	SNV	Pathogenic	16339	rs121913483	GRCh37: 4:1803568-1803568 GRCh38: 4:1801841-1801841
4	FGFR3	NM_000142.5(FGFR3):c.749C>G (p.Pro250Arg)	SNV	Pathogenic	16340	rs4647924	GRCh37: 4:1803571-1803571 GRCh38: 4:1801844-1801844
5	FGFR3	NM_000142.5(FGFR3):c.1138G>A (p.Gly380Arg)	SNV	Pathogenic	16327	rs28931614	GRCh37: 4:1806119-1806119 GRCh38: 4:1804392-1804392
6	FGFR3	NM_000142.5(FGFR3):c.1620C>G (p.Asn540Lys)	SNV	Pathogenic	16338	rs28933068	GRCh37: 4:1807371-1807371 GRCh38: 4:1805644-1805644
7	FGFR3	NM_000142.5(FGFR3):c.1949A>C (p.Lys650Thr)	SNV	Pathogenic	65855	rs121913105	GRCh37: 4:1807890-1807890 GRCh38: 4:1806163-1806163
8	BCL10	NM_003921.5(BCL10):c.488C>T (p.Thr163Met)	SNV	Pathogenic	30361	rs370432633	GRCh37: 1:85733524-85733524 GRCh38: 1:85267841-85267841
9	STK11	NM_000455.5(STK11):c.719C>G (p.Ser240Trp)	SNV	Likely Pathogenic	182902	rs730881976	GRCh37: 19:1220701-1220701 GRCh38: 19:1220702-1220702
10	STK11	NM_000455.5(STK11):c.1012G>A (p.Val338Met)	SNV	Uncertain Significance	142198	rs587782302	GRCh37: 19:1223075-1223075 GRCh38: 19:1223076-1223076
11	STK11	NM_000455.5(STK11):c.1195C>A (p.Gln399Lys)	SNV	Uncertain Significance	403791	rs1060499968	GRCh37: 19:1226539-1226539 GRCh38: 19:1226540-1226540
12	STK11	NM_000455.5(STK11):c.1243C>G (p.Arg415Gly)	SNV	Uncertain Significance	220264	rs864622448	GRCh37: 19:1226587-1226587 GRCh38: 19:1226588-1226588
13	FGFR3	NM_000142.5(FGFR3):c.1993G>T (p.Ala665Ser)	SNV	Uncertain Significance	465350	rs764892330	GRCh37: 4:1808017-1808017 GRCh38: 4:1806290-1806290
14	KIT	NM_000222.3(KIT):c.101C>T (p.Pro34Leu)	SNV	Uncertain Significance	409788	rs55755457	GRCh37: 4:55561711-55561711 GRCh38: 4:54695545-54695545
15	KIT	NM_000222.3(KIT):c.1553C>T (p.Pro518Leu)	SNV	Uncertain Significance	237245	rs569408054	GRCh37: 4:55593396-55593396 GRCh38: 4:54727230-54727230
16	KIT	NM_000222.3(KIT):c.302A>G (p.His101Arg)	SNV	Uncertain Significance	458940	rs1274601103	GRCh37: 4:55561912-55561912 GRCh38: 4:54695746-54695746
17	KIT	NM_000222.3(KIT):c.200C>G (p.Thr67Ser)	SNV	Uncertain Significance	237252	rs144933028	GRCh37: 4:55561810-55561810 GRCh38: 4:54695644-54695644
18	KIT	NM_000222.3(KIT):c.2900C>G (p.Ser967Cys)	SNV	Uncertain Significance	458936	rs1232060384	GRCh37: 4:55604692-55604692 GRCh38: 4:54738526-54738526
19	KIT	NM_000222.3(KIT):c.2887A>G (p.Thr963Ala)	SNV	Uncertain Significance	409774	rs773709702	GRCh37: 4:55604679-55604679 GRCh38: 4:54738513-54738513
20	KIT	NM_000222.3(KIT):c.2294A>G (p.Asp765Gly)	SNV	Uncertain Significance	409730	rs1060502545	GRCh37: 4:55598097-55598097 GRCh38: 4:54731931-54731931
21	STK11	NM_000455.5(STK11):c.632G>A (p.Arg211Gln)	SNV	Uncertain Significance	182910	rs730881982	GRCh37: 19:1220614-1220614 GRCh38: 19:1220615-1220615
22	STK11	NM_000455.5(STK11):c.566C>T (p.Thr189Ile)	SNV	Uncertain Significance	141128	rs587781515	GRCh37: 19:1220473-1220473 GRCh38: 19:1220474-1220474
23	STK11	NM_000455.5(STK11):c.464+5G>A	SNV	Uncertain Significance	141354	rs587781681	GRCh37: 19:1219417-1219417 GRCh38: 19:1219418-1219418
24	KIT	NM_000222.3(KIT):c.2881G>A (p.Gly961Ser)	SNV	Uncertain Significance	237271	rs773828910	GRCh37: 4:55604673-55604673 GRCh38: 4:54738507-54738507
25	KIT	NM_000222.3(KIT):c.2836C>T (p.Arg946Ter)	SNV	Uncertain Significance	576610	rs139000082	GRCh37: 4:55604628-55604628 GRCh38: 4:54738462-54738462
26	KIT	NM_000222.3(KIT):c.2104C>G (p.Leu702Val)	SNV	Uncertain Significance	409779	rs768847037	GRCh37: 4:55595614-55595614 GRCh38: 4:54729448-54729448
27	KIT	NM_000222.3(KIT):c.2057G>A (p.Arg686His)	SNV	Uncertain Significance	458902	rs143772138	GRCh37: 4:55595567-55595567 GRCh38: 4:54729401-54729401
28	KIT	NM_000222.3(KIT):c.2863G>T (p.Val955Leu)	SNV	Uncertain Significance	409783	rs1060502568	GRCh37: 4:55604655-55604655 GRCh38: 4:54738489-54738489
29	FGFR3	NM_000142.5(FGFR3):c.200G>A (p.Gly67Asp)	SNV	Uncertain Significance	546226	rs369232922	GRCh37: 4:1801071-1801071 GRCh38: 4:1799344-1799344
30	FGFR3	NM_000142.5(FGFR3):c.2153A>G (p.Asn718Ser)	SNV	Uncertain Significance	521225	rs139773438	GRCh37: 4:1808395-1808395 GRCh38: 4:1806668-1806668

Copy number variations for Testicular Cancer from CNVD:

⁶

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	61546	12	1	35400000	Gain		Testicular cancer
2	202070	5	76900000	102800000	Loss		Testicular cancer
3	217038	7	1	158821424	Gain		Testicular cancer
4	237464	8	23300000	146274826	Gain		Testicular cancer
5	262544	X	37500000	154913754	Gain		Testicular cancer
6	262545	X	37500000	154913754	Gain		Testicular cancer
7	266960	Y	174481503	174538309	Deletion	AZF1	Testicular cancer