MCID: TST015
MIFTS: 42

Testicular Disease

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Disease

MalaCards integrated aliases for Testicular Disease:

Name: Testicular Disease 12 15 17
Testicular Dysfunction 54 70 32
Testicular Diseases 54 44 70
Abnormality of the Testis 29
Testicular Disorders 42
Disorder of Testis 12
Testis Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2519
MeSH 44 D013733
NCIt 50 C26890
SNOMED-CT 67 236763001
ICD10 32 E29 E29.9
UMLS 70 C0039584 C0405581

Summaries for Testicular Disease

MedlinePlus : 42 Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It's easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports. You should examine your testicles monthly and seek medical attention for lumps, redness, pain or other changes. Testicles can get inflamed or infected. They can also develop cancer. Testicular cancer is rare and highly treatable. It usually happens between the ages of 15 and 40.

MalaCards based summary : Testicular Disease, also known as testicular dysfunction, is related to sexual disorder and testicular cancer, and has symptoms including pelvic pain An important gene associated with Testicular Disease is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Defensins and Th1 Differentiation Pathway. Affiliated tissues include testis, testes and pituitary, and related phenotype is neoplasm.

Wikipedia : 73 Testicle or testis (plural testes) is the male reproductive gland or gonad in all animals, including... more...

Related Diseases for Testicular Disease

Diseases related to Testicular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 449)
# Related Disease Score Top Affiliating Genes
1 sexual disorder 30.9 H2AC18 GNRH1 EPPIN
2 testicular cancer 30.5 MIR199A1 INSL3 GNRH1 CD4 AFP
3 leukemia, acute lymphoblastic 30.5 MLLT1 MIR199A1 H2AC18 CD4 CCR6
4 acquired immunodeficiency syndrome 30.4 TNF IL10 CD4 CCR6
5 orchitis 30.4 TNF IL10 H2AC18 EPPIN CD4
6 childhood type dermatomyositis 30.4 TNF CD4 CCR6
7 mature teratoma 30.4 MIR302A H2AC18 AFP
8 leydig cell tumor 30.4 INSL3 GNRH1 AFP
9 spondylitis 30.3 TNF IL10 CCR6
10 cryptorchidism, unilateral or bilateral 30.3 INSL3 IGFL3 GNRH1 EPPIN AFP
11 ulcerative colitis 30.2 TNF LACC1 IL10 CCR6
12 lymphadenitis 30.2 TNF SLC11A1 IL10 CD4 CCR6
13 gastrointestinal system disease 30.2 MIR199A1 MIR181A1 H2AC18 CCR6
14 colitis 30.2 TNF LACC1 IL10 CD4 CCR6
15 body mass index quantitative trait locus 11 30.1 TNF MIR199A1 MIR181A1 IL10 H2AC18 CD4
16 leprosy 3 30.0 TNF SLC11A1 SDHD PACRG MLLT1 LACC1
17 nonsyndromic 46,xx testicular disorders of sex development 11.1
18 46,xx sex reversal 11.1
19 46,xx sex reversal 1 11.0
20 punctate inner choroidopathy 10.5 TNF IL10
21 tropical endomyocardial fibrosis 10.5 TNF IL10
22 anogenital venereal wart 10.5 H2AC18 CD4 CCR6
23 syphilis 10.5 TNF CD4 CCR6
24 abdominal tuberculosis 10.5 TNF CD4 AFP
25 uterine benign neoplasm 10.5 H2AC18 GNRH1 EPPIN
26 pneumonic tularemia 10.5 TNF CD4 CCR6
27 reproductive organ benign neoplasm 10.5 H2AC18 GNRH1 EPPIN AFP
28 mikulicz disease 10.5 IL10 CD4 CCR6
29 scleral disease 10.5 TNF CD4 CCR6
30 goodpasture syndrome 10.5 H2AC18 CD4 CCR6
31 subcutaneous mycosis 10.5 IL10 CD4 CCR6
32 corpus luteum cyst 10.5 GNRH1 AFP
33 autoimmune vasculitis 10.5 TNF CD4 CCR6
34 parasitic ectoparasitic infectious disease 10.5 H2AC18 CD4 CCR6
35 dacryoadenitis 10.5 IL10 CD4 CCR6
36 acute proliferative glomerulonephritis 10.5 TNF CD4 CCR6
37 scabies 10.5 IL10 CD4 CCR6
38 pelvic varices 10.5 TNF INSL3 GNRH1 EPPIN
39 polyarticular juvenile idiopathic arthritis 10.5 TNF LACC1
40 hereditary lymphedema 10.5 H2AC18 GNRH1 CCR6
41 retinal vasculitis 10.5 TNF CD4 CCR6
42 hereditary lymphedema i 10.5 H2AC18 GNRH1 CCR6
43 legume allergy 10.5 IL10 CD4 CCR6
44 childhood endodermal sinus tumor 10.5 MIR302A AFP
45 fruit allergy 10.5 IL10 CD4 CCR6
46 multifocal choroiditis 10.5 TNF IL10
47 endodermal sinus tumor 10.5 MIR302A MIR199A1 AFP
48 cutaneous leishmaniasis 10.5 TNF SLC11A1 IL10
49 pneumocystosis 10.5 TNF CD4 CCR6
50 endogenous depression 10.5 TNF H2AC18 GNRH1

Graphical network of the top 20 diseases related to Testicular Disease:



Diseases related to Testicular Disease

Symptoms & Phenotypes for Testicular Disease

UMLS symptoms related to Testicular Disease:


pelvic pain

MGI Mouse Phenotypes related to Testicular Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 AFP GNRH1 IL10 MLLT1 SDHD SLC11A1

Drugs & Therapeutics for Testicular Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Avelumab in Multiple Relapsed/Refractory Testicular Germ Cell Cancer. Completed NCT03403777 Phase 2 Avelumab
2 Up-positioning of the Testes as Supportive Therapy in Patients With Acute Orchitis - a Randomized Controlled Trial Unknown status NCT02665182
3 Evaluation of the Impact of Open or Laparoscopic Preperitoneal Inguinal Hernia Repair on Arterial and Venous Testicular Vascularization by Means of Ecocolordoppler Ultrasound Examination Unknown status NCT03056027
4 Anti-1-amino-3-18F-flurocyclobutane-1-carboxylic Acid (Axumin) Positron Emission Tomography/Computed Tomography Prior to Retroperitoneal Lymph Node Dissection for Testicular Cancer Completed NCT03426865 Axumin PET scan
5 Human Sperm Zona Acceptor: Environmental Effects Completed NCT00012480

Search NIH Clinical Center for Testicular Disease

Cochrane evidence based reviews: testicular diseases

Genetic Tests for Testicular Disease

Genetic tests related to Testicular Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Testis 29

Anatomical Context for Testicular Disease

MalaCards organs/tissues related to Testicular Disease:

40
Testis, Testes, Pituitary, Ovary, Bone, Skin, Lymph Node

Publications for Testicular Disease

Articles related to Testicular Disease:

(show top 50) (show all 615)
# Title Authors PMID Year
1
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 42
33530122 2021
2
Nitroglycerin ameliorates sperm parameters, oxidative stress and testicular injury following by testicular torsion/detorsion in male rats. 42
33147433 2020
3
Targeted Microsurgical Denervation of the Spermatic Cord for Chronic Orchialgia: the Current Standard of Care. 42
32926242 2020
4
Baseline follicle-stimulating hormone is a strong predictor for the outcome of the gonadotrophin-releasing hormone test in young men with unilateral medium- or high-grade varicocele. 54 61
16925763 2006
5
Chronic exercise training attenuates prostate cancer-induced molecular remodelling in the testis. 61
33074478 2021
6
Mitochondria-Mediated Apoptosis Induced Testicular Dysfunction in Diabetic Rats: Ameliorative Effect of Resveratrol. 61
33506262 2021
7
Corrigendum to "Fermented Maillard reaction products attenuate stress-induced testicular dysfunction in mice" (J. Dairy Sci. 104:1384-1396). 61
33752290 2021
8
Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats. 61
33058396 2021
9
Flufenoxuron suppresses the proliferation of testicular cells by targeting mitochondria in mice. 61
33771252 2021
10
Impacts of n-acetyl cysteine on gibberellic acid-induced testicular dysfunction through regulation of inflammatory cytokines, steroid and antioxidant activity. 61
33724537 2021
11
Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways. 61
33453244 2021
12
Blood testis barrier revisited-Analysis of post-chemotherapy germ cell tumor orchidectomy and retroperitoneal lymph node dissection specimens. 61
33428791 2021
13
Clinical and seminal parameters associated with testicular microlithiasis and its severity in males from infertile couples. 61
33406236 2021
14
Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats. 61
33754266 2021
15
Protective and therapeutic effect of Hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with Cyclophosphamide. 61
33550762 2021
16
Insights into the Regulation on Proliferation and Differentiation of Stem Leydig Cells. 61
33598893 2021
17
Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation. 61
33581194 2021
18
Evaluation of Gonadal Alterations in a Population Environmentally Exposed to a Mixture of Endocrine Active Pesticides. 61
33670911 2021
19
Assessment of the accuracy of testicular dysfunction detection in male donkey (Equus asinus) with the aid of colour-spectral Doppler in relation to plasma testosterone and serum nitric oxide levels. 61
33595865 2021
20
Fermented Maillard reaction products attenuate stress-induced testicular dysfunction in mice. 61
33272581 2021
21
Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-10. 61
33548410 2021
22
Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis. 61
32942336 2021
23
Saponins derived from the stems and leaves of Panax ginseng attenuate scrotal heat-induced spermatogenic damage via inhibiting the MAPK mediated oxidative stress and apoptosis in mice. 61
32767418 2021
24
The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet. 61
33378981 2021
25
Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence. 61
33628321 2021
26
Effects of Juglans regia L. leaf extract supplementation on testicular functions in diabetic rats. 61
32476484 2021
27
Substance P restores spermatogenesis in busulfan-treated mice: A new strategy for male infertility therapy. 61
33181455 2021
28
[Diagnosis and treatment of male infertility]. 61
33491636 2021
29
European academy of andrology guidelines on Klinefelter Syndrome Endorsing Organization: European Society of Endocrinology. 61
32959490 2021
30
Gui-A-Gra Attenuates Testicular Dysfunction in Varicocele-Induced Rats via Oxidative Stress, ER Stress and Mitochondrial Apoptosis Pathway. 61
33287403 2020
31
Infertility duration and pre-operative sperm progressive motility are significant factors of spontaneous pregnancy after varicocele repair. 61
32770830 2020
32
Bromelain from Ananas comosus stem attenuates oxidative toxicity and testicular dysfunction caused by aluminum in rats. 61
32763766 2020
33
Selenium sources differ in their potential to alleviate the cadmium-induced testicular dysfunction. 61
33254640 2020
34
Cyperus esculentus L. (tigernut) mitigates high salt diet-associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation. 61
32816391 2020
35
Testicular Involvement is a Hallmark of Apo A-I Leu75Pro Mutation Amyloidosis. 61
32841328 2020
36
Lycium chinense Mill improves hypogonadism via anti-oxidative stress and anti-apoptotic effect in old aged rat model. 61
30269620 2020
37
Elevated CCL2 causes Leydig cell malfunction in metabolic syndrome. 61
33148888 2020
38
Prostate-Specific Antigen Concentrations in Response to Testosterone Treatment of Severely Hypogonadal Men. 61
33134766 2020
39
Hypogonadism and bone health in men with HIV. 61
33128905 2020
40
Managing traumatic testicular dislocations: what we know after two centuries. 61
33148579 2020
41
Bifenthrin impairs the functions of Leydig and Sertoli cells in mice via mitochondrion-endoplasmic reticulum dysregulation. 61
32683091 2020
42
Endocrinological Testicular Dysfunction in Patients with Lepromatous Leprosy and the Impact of Disease on Patient's Quality of Life. 61
33344347 2020
43
Comparative Protective Effects of N-Acetylcysteine, and Melatonin against Obesity- Induced Testicular Dysfunction in Rats. 61
33201734 2020
44
Testicular microlithiasis on scrotal ultrasound in 4850 young men from the general population: associations with semen quality. 61
32619084 2020
45
Loranthus micranthus nanoparticles abates streptozotocin-instigated testicular dysfunction in Wistar rats: Involvement of glucose metabolism enzymes, oxido-inflammatory stress, steroidogenic enzymes/protein and Nrf2 pathway. 61
32672386 2020
46
Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility. 61
33006953 2020
47
Data and data illustrations supporting the analysis of transcripts from interviews exploring the views and experiences of young men and their parents/guardians regarding testicular health. 61
32885003 2020
48
Protective role of wogonin against cadmium induced testicular toxicity: Involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways. 61
32781062 2020
49
Acrosomal marker SP-10 (gene name Acrv1) for staging of the cycle of seminiferous epithelium in the stallion. 61
32758798 2020
50
Anti-inflammatory effect of selenium on lead-induced testicular inflammation by inhibiting NLRP3 inflammasome activation in chickens. 61
32673849 2020

Variations for Testicular Disease

Copy number variations for Testicular Disease from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 266734 Y 1 27200000 Chromosomal abnormalities Testicular failure
2 267190 Y 25400000 27200000 Deletion AZF1 Testicular failure
3 267191 Y 25400000 27200000 Deletion Testicular failure
4 267192 Y 25400000 27200000 Deletion Testicular failure

Expression for Testicular Disease

Search GEO for disease gene expression data for Testicular Disease.

Pathways for Testicular Disease

GO Terms for Testicular Disease

Cellular components related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 TNF MIR199A1 MIR181A1 INSL3 IL10 IGFL3
2 sperm plasma membrane GO:0097524 8.96 EPPIN CCR6

Biological processes related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 TNF SLC11A1 IL10 CD4 CCR6
2 defense response to bacterium GO:0042742 9.67 TNF SLC11A1 IL10 EPPIN
3 negative regulation of interleukin-6 production GO:0032715 9.43 TNF MIR181A1 IL10
4 endothelial cell apoptotic process GO:0072577 9.16 TNF IL10
5 positive regulation of cytokine production GO:0001819 9.13 TNF SLC11A1 IL10
6 negative regulation of cytokine production involved in immune response GO:0002719 8.62 TNF IL10

Sources for Testicular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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