MCID: TST015
MIFTS: 49

Testicular Disease

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Disease

MalaCards integrated aliases for Testicular Disease:

Name: Testicular Disease 12 15
Testicular Diseases 55 44 73
Testicular Dysfunction 55 73
Abnormality of the Testis 29
Testicular Disorders 43
Disorder of Testis 12
Testis Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2519
MeSH 44 D013733
NCIt 50 C26890
SNOMED-CT 68 64910008
ICD10 33 E29

Summaries for Testicular Disease

MedlinePlus : 43 Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It's easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports. You should examine your testicles monthly and seek medical attention for lumps, redness, pain or other changes. Testicles can get inflamed or infected. They can also develop cancer. Testicular cancer is rare and highly treatable. It usually happens between the ages of 15 and 40.

MalaCards based summary : Testicular Disease, also known as testicular diseases, is related to testicular cancer and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity, and has symptoms including pelvic pain An important gene associated with Testicular Disease is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. The drugs Cisplatin and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and skin, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 The testicle or testis is the male reproductive gland in all animals, including humans. It is homologous... more...

Related Diseases for Testicular Disease

Diseases related to Testicular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 testicular cancer 29.8 AFP INSL3 RXFP2
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.7 HSPD1 IFNG IL10
3 acquired immunodeficiency syndrome 29.7 IFNG IL10 IL2 TNF
4 ulcerative colitis 29.6 IFNG IL10 IL2 LACC1 TNF
5 colitis 29.6 IFNG IL10 IL2 LACC1 TNF
6 autoimmune disease 29.4 HSPD1 IFNG IL10 IL2 SLC11A1 TNF
7 46,xx sex reversal 1 12.1
8 nonsyndromic 46,xx testicular disorders of sex development 12.0
9 46,xx sex reversal 2 11.3
10 testicular anomalies with or without congenital heart disease 10.5
11 adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency 10.3
12 hypogonadism-cataract syndrome 10.3
13 hypergonadotropic hypogonadism and partial alopecia 10.3
14 17-beta hydroxysteroid dehydrogenase iii deficiency 10.3
15 46,xy sex reversal 8 10.3
16 transient hypogammaglobulinemia 10.3 IL10 TNF
17 chronic beryllium disease 10.3 IFNG TNF
18 oral tuberculosis 10.3 IL2 TNF
19 borderline leprosy 10.3 MLLT1 SDHD
20 punctate inner choroidopathy 10.3 IL10 TNF
21 neurosyphilis 10.3 IL10 TLR2
22 tropical endomyocardial fibrosis 10.3 IL10 TNF
23 endomyocardial fibrosis 10.3 IL10 TNF
24 variola major 10.3 IFNG IL2
25 cephalosporin allergy 10.3 IFNG IL10
26 gonadal disease 10.2 AFP GNRH1 MLLT1
27 staphylococcal toxic shock syndrome 10.2 IFNG TNF
28 anorchia 10.2 INSL3 RXFP2
29 testicular granulosa cell tumor 10.2 AFP DICER1
30 juvenile type testicular granulosa cell tumor 10.2 AFP DICER1
31 lymphatic system disease 10.2 IL2 SDHD TNF
32 hyperlucent lung 10.2 IFNG IL10
33 microscopic polyangiitis 10.2 IL10 TNF
34 multifocal choroiditis 10.2 IL10 TNF
35 autoimmune myocarditis 10.2 IFNG TNF
36 post-transplant lymphoproliferative disease 10.2 IL10 SLC11A1 TNF
37 multidrug-resistant tuberculosis 10.2 IL10 SLC11A1 TNF
38 tungiasis 10.2 IL10 TNF
39 lymph node disease 10.2 IL10 SDHD TNF
40 trench fever 10.2 TLR2 TNF
41 autoimmune gastritis 10.2 IL10 IL2 TNF
42 streptococcal toxic-shock syndrome 10.2 IL2 TNF
43 crohn's colitis 10.2 IFNG IL2 TNF
44 uveitis 10.2 IFNG IL10 TNF
45 fixed drug eruption 10.2 IFNG IL2
46 posterior uveitis 10.2 IFNG IL2 TNF
47 commensal bacterial infectious disease 10.2 IL10 IL2 TNF
48 nontuberculous mycobacterial lung disease 10.2 SLC11A1 TLR2 TNF
49 rheumatic fever 10.2 IL10 IL2 TNF
50 prostatitis 10.2 IL10 IL2 TNF

Graphical network of the top 20 diseases related to Testicular Disease:



Diseases related to Testicular Disease

Symptoms & Phenotypes for Testicular Disease

UMLS symptoms related to Testicular Disease:


pelvic pain

MGI Mouse Phenotypes related to Testicular Disease:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.37 AFP CALB2 CCDC122 DICER1 HSPD1 IFNG
2 cellular MP:0005384 10.25 DICER1 HSPD1 IFNG IL10 IL2 INSL3
3 hematopoietic system MP:0005397 10.23 DICER1 GNRH1 IFNG IL10 IL2 LACC1
4 endocrine/exocrine gland MP:0005379 10.22 AFP DICER1 GNRH1 IFNG IL10 IL2
5 homeostasis/metabolism MP:0005376 10.21 AFP CCDC122 DICER1 GNRH1 IFNG IL10
6 immune system MP:0005387 10.14 DICER1 GNRH1 IFNG IL10 IL2 LACC1
7 neoplasm MP:0002006 10.1 AFP DICER1 GNRH1 IFNG IL10 IL2
8 liver/biliary system MP:0005370 10.07 AFP DICER1 GNRH1 IFNG IL10 IL2
9 digestive/alimentary MP:0005381 10.04 GNRH1 IFNG IL10 IL2 SLC11A1 TLR2
10 nervous system MP:0003631 10 CALB2 DICER1 GNRH1 HSPD1 IFNG IL10
11 reproductive system MP:0005389 9.85 AFP DICER1 GNRH1 HSPD1 IFNG IL10
12 respiratory system MP:0005388 9.5 DICER1 IFNG IL10 IL2 RXFP2 TLR2
13 skeleton MP:0005390 9.28 CCDC122 DICER1 GNRH1 IFNG IL10 INSL3

Drugs & Therapeutics for Testicular Disease

Drugs for Testicular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 269)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
3
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
4 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
5 Hypnotics and Sedatives Phase 4,Phase 2,Not Applicable
6 Anesthetics, General Phase 4,Phase 2,Not Applicable
7 Anesthetics, Intravenous Phase 4,Not Applicable
8 Anesthetics Phase 4,Phase 2,Not Applicable
9
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
10
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
11
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 43805 6857599 5310940 9887054
12
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
13
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
14
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
15
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
16
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
17
Vinblastine Approved Phase 3 865-21-4 241903 13342
18
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
19
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
21
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
22
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
23
Prednisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 53-03-2 5865
24
Vincristine Approved, Investigational Phase 3,Phase 2,Not Applicable 57-22-7, 2068-78-2 5978
25
Thioguanine Approved Phase 3,Not Applicable 154-42-7 2723601
26
Pegaspargase Approved, Investigational Phase 3,Not Applicable 130167-69-0
27
Cortisone acetate Approved, Investigational Phase 3 1950-04-4, 50-04-4 5745
28
Methotrexate Approved Phase 3,Not Applicable 59-05-2, 1959-05-2 126941
29
Daunorubicin Approved Phase 3,Not Applicable 20830-81-3 30323
30
leucovorin Approved Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
31
Doxorubicin Approved, Investigational Phase 3,Not Applicable 23214-92-8 31703
32
Levoleucovorin Approved, Investigational Phase 3,Phase 2 68538-85-2
33
Cytarabine Approved, Investigational Phase 3,Not Applicable 147-94-4 6253
34
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
35
Ofloxacin Approved Phase 3 82419-36-1 4583
36
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
37
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
38
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
39
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
40
Promethazine Approved, Investigational Phase 3 60-87-7 4927
41
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
42
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
43
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
44 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
45
Polyestradiol phosphate Approved Phase 3 28014-46-2
46
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
47
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Not Applicable 59-30-3 6037
49
Doxil Approved June 1999 Phase 3,Not Applicable 31703
50
Cortisone Experimental Phase 3 53-06-5 222786

Interventional clinical trials:

(show top 50) (show all 198)
# Name Status NCT ID Phase Drugs
1 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4 Sevofluorane;Propofol
2 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
3 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
4 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
5 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
6 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
8 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
9 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
10 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
11 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
12 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
13 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
14 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
15 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
16 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
17 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
18 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
20 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
21 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
22 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
23 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
24 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
25 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
26 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
27 Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in Children Completed NCT01701778 Phase 2 Caudal Dexmedetomidine;Intravenous Dexmedetomidine;Placebo;sevoflurane
28 Conventional Dose Versus High Dose Sequential Chemotherapy for Poor Prognosis Germ Cell Tumors Completed NCT02161692 Phase 2 Cyclophosphamide;Etoposide;Cisplatin;Bleomycin;Carboplatin
29 Safety and Efficacy of FalateScan (Technetium Tc 99m EC20) in Patients With Known Suspected Recurrent or Metastatic Cancer From a Solid Tumor Completed NCT01684098 Phase 2 Tc 99m EC20
30 Everolimus in Refractory Testicular Germ Cell Cancer Completed NCT01466231 Phase 2 Everolimus
31 Everolimus for Patients With Relapsed/Refractory Germ Cell Cancer Completed NCT01242631 Phase 2 Everolimus
32 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
33 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
34 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
35 Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases Completed NCT00587964 Phase 2
36 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
37 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
38 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
39 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
40 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
41 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
42 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
43 High-dose Chemotherapy With Autologous Stem Cell Transplantation in Poor Prognosis Germ-cell Tumors: TAXIF II Completed NCT00231582 Phase 2 epirubicin;paclitaxel;etoposide;ifosfamide;carboplatin
44 Study of Gemcitabine, Oxaliplatin, and Paclitaxel in Patients With Refractory Germ Cell Carcinoma Completed NCT00183820 Phase 2 paclitaxel, gemcitabine, and oxaliplatin
45 Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Cancers of Low Incidence Completed NCT00123773 Phase 2
46 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
47 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
48 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
49 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
50 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2

Search NIH Clinical Center for Testicular Disease

Cochrane evidence based reviews: testicular diseases

Genetic Tests for Testicular Disease

Genetic tests related to Testicular Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Testis 29

Anatomical Context for Testicular Disease

MalaCards organs/tissues related to Testicular Disease:

41
Testis, Testes, Skin, Bone, Ovary, Pituitary, T Cells

Publications for Testicular Disease

Articles related to Testicular Disease:

(show all 19)
# Title Authors Year
1
Histopathological pattern of testicular diseases in western Saudi Arabia. ( 29738007 )
2018
2
Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation. ( 20589462 )
2010
3
Overt testicular disease (OTD) at diagnosis is not associated with a poor prognosis in childhood acute lymphoblastic leukemia: results of the EORTC CLG Study 58881. ( 16358303 )
2007
4
Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation. ( 15973454 )
2005
5
Comparison of radionuclide imaging and ultrasonography in the differentiation of acute testicular torsion and inflammatory testicular disease. ( 12072775 )
2002
6
Blood plasma concentrations of oestradiol-17beta, testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular diseases. ( 12443684 )
2002
7
Testicular disease in childhood B-cell non-Hodgkin's lymphoma: the French Society of Pediatric Oncology experience. ( 11331318 )
2001
8
Overt testicular disease at diagnosis is associated with high risk features and a poor prognosis in patients with childhood acute lymphoblastic leukemia. ( 8941016 )
1996
9
Primary testicular disease presenting as azoospermia or oligozoospermia in an infertility clinic. ( 8102079 )
1993
10
MR imaging in the differential diagnosis of scrotal and testicular disease. ( 1996400 )
1991
11
Contralateral testicular disease after unilateral testicular injury: current concepts. ( 2903525 )
1988
12
Unilateral testicular disease: effect on the contralateral testis (morphometric study). ( 3116283 )
1987
13
Diffuse testicular disease: sonographic features and significance. ( 2998170 )
1985
14
Testicular disease in Singapore children with acute leukemia. ( 6595957 )
1984
15
Exocrine and endocrine testicular function in patients with unilateral testicular disease. ( 6136609 )
1983
16
Computed tomography in testicular disease: a review. ( 7019438 )
1981
17
The prognostic power of flow-through cytophotometric DNA determinations for testicular diseases. ( 7469199 )
1980
18
Testicular disease in acute lymphoblastic leukaemia in childhood. Report on behalf of the Medical Research Council's Working Party on leukaemia in childhood. ( 272221 )
1978
19
TESTICULAR DISEASE. ( 14265372 )
1965

Variations for Testicular Disease

Copy number variations for Testicular Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 266734 Y 1 27200000 Chromosomal abnormal ities Testicular failure
2 267190 Y 25400000 27200000 Deletion AZFa Testicular failure
3 267191 Y 25400000 27200000 Deletion AZFb Testicular failure
4 267192 Y 25400000 27200000 Deletion AZFc Testicular failure

Expression for Testicular Disease

Search GEO for disease gene expression data for Testicular Disease.

Pathways for Testicular Disease

Pathways related to Testicular Disease according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 IFNG IL10 IL2 TLR2 TNF
2 12.44 IFNG IL10 IL2 TLR2 TNF
3
Show member pathways
12.34 IFNG IL10 IL2 TNF
4
Show member pathways
12.18 IFNG IL10 TLR2 TNF
5
Show member pathways
12.14 GNRH1 IFNG IL10 IL2 TNF
6 12.08 HSPD1 IL10 MBD1 TNF
7 11.91 HSPD1 IFNG IL10 TLR2 TNF
8
Show member pathways
11.9 HSPD1 IFNG TLR2 TNF
9 11.84 IFNG IL10 IL2 TNF
10 11.77 IFNG TLR2 TNF
11 11.72 AFP IFNG IL2
12 11.72 IFNG IL10 TLR2 TNF
13
Show member pathways
11.68 IFNG IL2 TNF
14 11.61 IFNG IL10 IL2 TNF
15
Show member pathways
11.59 IFNG IL2 TNF
16
Show member pathways
11.57 IFNG IL2 TNF
17 11.54 IFNG IL10 IL2 TNF
18 11.51 HSPD1 TLR2 TNF
19 11.48 IFNG IL2 TNF
20 11.47 IFNG IL10 IL2 TNF
21
Show member pathways
11.47 IFNG IL10 IL2 TLR2 TNF
22 11.44 IFNG IL2 TNF
23 11.43 IFNG TLR2 TNF
24 11.4 IFNG IL10 IL2
25 11.23 IFNG IL10 TNF
26 11.15 IFNG IL10 TLR2 TNF
27 11.05 IFNG IL10 IL2
28 10.39 IFNG IL10 IL2 TNF

GO Terms for Testicular Disease

Cellular components related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 AFP GNRH1 HSPD1 IFNG IGFL3 IL10

Biological processes related to Testicular Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 GNRH1 HSPD1 IL10 IL2 RXFP2
2 immune response GO:0006955 9.88 IFNG IL10 IL2 SLC11A1 TLR2 TNF
3 regulation of signaling receptor activity GO:0010469 9.73 GNRH1 IFNG IL10 IL2 INSL3 TNF
4 response to organic substance GO:0010033 9.72 HSPD1 IL10 TNF
5 response to glucocorticoid GO:0051384 9.7 HSPD1 IL10 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.67 HSPD1 TLR2 TNF
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IFNG TNF
8 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG IL2
9 negative regulation of growth of symbiont in host GO:0044130 9.57 IL10 TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
11 response to molecule of bacterial origin GO:0002237 9.54 IL10 TLR2
12 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
13 positive regulation of interleukin-12 production GO:0032735 9.5 HSPD1 IFNG TLR2
14 negative regulation of cytokine secretion involved in immune response GO:0002740 9.48 IL10 TNF
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IFNG TNF
16 positive regulation of inflammatory response GO:0050729 9.46 HSPD1 IL2 TLR2 TNF
17 receptor biosynthetic process GO:0032800 9.43 IL10 TNF
18 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
19 response to lipopolysaccharide GO:0032496 9.35 GNRH1 HSPD1 IL10 SLC11A1 TLR2
20 positive regulation of interferon-gamma production GO:0032729 8.92 HSPD1 IL2 SLC11A1 TNF

Molecular functions related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 HSPD1 INSL3 TNF
2 cytokine activity GO:0005125 8.92 IFNG IL10 IL2 TNF

Sources for Testicular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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