MCID: TST015
MIFTS: 44

Testicular Disease

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Disease

MalaCards integrated aliases for Testicular Disease:

Name: Testicular Disease 12 15
Testicular Diseases 55 44 73
Testicular Dysfunction 55 73
Abnormality of the Testis 29
Testicular Disorders 43
Disorder of Testis 12
Testis Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2519
MeSH 44 D013733
NCIt 50 C26890
ICD10 33 E29

Summaries for Testicular Disease

MedlinePlus : 43 Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It's easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports. You should examine your testicles monthly and seek medical attention for lumps, redness, pain or other changes. Testicles can get inflamed or infected. They can also develop cancer. Testicular cancer is rare and highly treatable. It usually happens between the ages of 15 and 40.

MalaCards based summary : Testicular Disease, also known as testicular diseases, is related to 46,xx sex reversal 1 and varicocele, and has symptoms including pelvic pain An important gene associated with Testicular Disease is INSL3 (Insulin Like 3), and among its related pathways/superpathways is Deactivation of the beta-catenin transactivating complex. The drugs Cisplatin and Propofol have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are Negative genetic interaction between PTEN-/- and PTEN+/+ and behavior/neurological

Related Diseases for Testicular Disease

Diseases related to Testicular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 46,xx sex reversal 1 33.2 SOX9 SRY
2 varicocele 29.8 CASP3 CGA NOS3
3 testicular torsion 29.8 CATSPER1 INSL3 TWIST1
4 nonsyndromic 46,xx testicular disorders of sex development 11.9
5 46,xx sex reversal 2 11.2
6 atypical choroid plexus papilloma 10.5 SRY TWIST1
7 intracranial hypotension 10.5 GJB6 TWIST1
8 tendinopathy 10.4 CASP3 NOS3
9 testicular anomalies with or without congenital heart disease 10.3
10 deafness, autosomal dominant 24 10.3 CASP3 GJB6
11 complete androgen insensitivity syndrome 10.3 CGA SRY
12 anorchia 10.3 CGA INSL3 SRY
13 hepatic infarction 10.3 EDA GJB6
14 46,xy partial gonadal dysgenesis 10.2 SOX9 SRY
15 adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency 10.2
16 hypogonadism-cataract syndrome 10.2
17 hypergonadotropic hypogonadism and partial alopecia 10.2
18 17-beta hydroxysteroid dehydrogenase iii deficiency 10.2
19 46,xy sex reversal 8 10.2
20 mixed gonadal dysgenesis 10.2 SOX9 SRY
21 hermaphroditism 10.1 SOX9 SRY
22 androgen insensitivity syndrome 10.0 CGA SRY
23 persistent mullerian duct syndrome 10.0 INSL3 SOX9 SRY
24 gonadoblastoma 10.0 SOX9 SRY
25 hypospadias 10.0 INSL3 SOX9 SRY
26 campomelic dysplasia 9.9 SOX9 SRY
27 leukemia 9.8
28 leukemia, acute lymphoblastic 9.8
29 lymphoblastic leukemia 9.8
30 clouston syndrome 9.7 EDA GJB6
31 hypothyroidism 9.7
32 hypogonadism 9.7
33 prader-willi syndrome 9.6
34 male infertility 9.6
35 testicular cancer 9.5
36 acute leukemia 9.5
37 lymphoma 9.5
38 azoospermia 9.5
39 infertility 9.5
40 cryptorchidism, unilateral or bilateral 9.3 CGA IGFL3 INSL3 SRY
41 orchitis 8.9 EDA GJA3 GJB6 PROKR1 RNASE10

Graphical network of the top 20 diseases related to Testicular Disease:



Diseases related to Testicular Disease

Symptoms & Phenotypes for Testicular Disease

UMLS symptoms related to Testicular Disease:


pelvic pain

GenomeRNAi Phenotypes related to Testicular Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 9.02 EDA INSL3 PROKR1 SOX9 TWIST1

MGI Mouse Phenotypes related to Testicular Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 CASP3 GJB6 INSL3 NOS3 PROKR1 RNASE10
2 endocrine/exocrine gland MP:0005379 9.5 INSL3 NOS3 RNASE10 SOX9 CASP3 CGA
3 reproductive system MP:0005389 9.23 CASP3 CATSPER1 CGA INSL3 NOS3 PROKR1

Drugs & Therapeutics for Testicular Disease

Drugs for Testicular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 265)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
4 Anesthetics Phase 4,Phase 2,Not Applicable
5 Anesthetics, General Phase 4,Phase 2,Not Applicable
6 Anesthetics, Intravenous Phase 4,Not Applicable
7 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
8 Hypnotics and Sedatives Phase 4,Phase 2,Not Applicable
9
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
10
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
11
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
12
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
13
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
14
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
15
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
16
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
17
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
18
Vinblastine Approved Phase 3 865-21-4 13342 241903
19
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
20
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
21
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
22
Cortisone acetate Approved, Investigational Phase 3 1950-04-4, 50-04-4 5745
23
Cytarabine Approved, Investigational Phase 3,Not Applicable 147-94-4 6253
24
Daunorubicin Approved Phase 3,Not Applicable 20830-81-3 30323
25
Doxorubicin Approved, Investigational Phase 3,Not Applicable 23214-92-8 31703
26
Levoleucovorin Approved, Investigational Phase 3,Phase 2 68538-85-2
27
Methotrexate Approved Phase 3,Not Applicable 1959-05-2, 59-05-2 126941
28
Pegaspargase Approved, Investigational Phase 3,Not Applicable 130167-69-0
29
Prednisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 53-03-2 5865
30
Thioguanine Approved Phase 3,Not Applicable 154-42-7 2723601
31
Vincristine Approved, Investigational Phase 3,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
32
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
33
Ofloxacin Approved Phase 3 82419-36-1 4583
34
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
35
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
36
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
37
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
38
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
39
Promethazine Approved, Investigational Phase 3 60-87-7 4927
40
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
41 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
42
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
43
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
44
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
45
Polyestradiol phosphate Approved Phase 3 28014-46-2
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Not Applicable 59-30-3 6037
47
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Not Applicable 58-05-9 143 6006
48
Doxil Approved June 1999 Phase 3,Not Applicable 31703
49 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
50 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 197)
# Name Status NCT ID Phase Drugs
1 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4 Sevofluorane;Propofol
2 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
3 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
4 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
5 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
6 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
8 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
9 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
10 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
11 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
12 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
13 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
14 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
15 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
16 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
17 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
18 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
20 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
21 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
22 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
23 Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor Unknown status NCT02784054 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin;Thiotepa;Melphalan
24 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
25 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
26 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
27 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
28 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
29 Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in Children Completed NCT01701778 Phase 2 Caudal Dexmedetomidine;Intravenous Dexmedetomidine;Placebo;sevoflurane
30 Conventional Dose Versus High Dose Sequential Chemotherapy for Poor Prognosis Germ Cell Tumors Completed NCT02161692 Phase 2 Cyclophosphamide;Etoposide;Cisplatin;Bleomycin;Carboplatin
31 Safety and Efficacy of FalateScan (Technetium Tc 99m EC20) in Patients With Known Suspected Recurrent or Metastatic Cancer From a Solid Tumor Completed NCT01684098 Phase 2 Tc 99m EC20
32 Everolimus in Refractory Testicular Germ Cell Cancer Completed NCT01466231 Phase 2 Everolimus
33 Everolimus for Patients With Relapsed/Refractory Germ Cell Cancer Completed NCT01242631 Phase 2 Everolimus
34 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
35 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
36 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
37 Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases Completed NCT00587964 Phase 2
38 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
39 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
40 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
41 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
42 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
43 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
44 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
45 High-dose Chemotherapy With Autologous Stem Cell Transplantation in Poor Prognosis Germ-cell Tumors: TAXIF II Completed NCT00231582 Phase 2 epirubicin;paclitaxel;etoposide;ifosfamide;carboplatin
46 Study of Gemcitabine, Oxaliplatin, and Paclitaxel in Patients With Refractory Germ Cell Carcinoma Completed NCT00183820 Phase 2 paclitaxel, gemcitabine, and oxaliplatin
47 Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Cancers of Low Incidence Completed NCT00123773 Phase 2
48 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
49 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
50 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel

Search NIH Clinical Center for Testicular Disease

Cochrane evidence based reviews: testicular diseases

Genetic Tests for Testicular Disease

Genetic tests related to Testicular Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Testis 29

Anatomical Context for Testicular Disease

MalaCards organs/tissues related to Testicular Disease:

41
Testis, Bone, Bone Marrow, Testes, Skin, Lymph Node, T Cells

Publications for Testicular Disease

Articles related to Testicular Disease:

(show all 16)
# Title Authors Year
1
Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation. ( 20589462 )
2010
2
Overt testicular disease (OTD) at diagnosis is not associated with a poor prognosis in childhood acute lymphoblastic leukemia: results of the EORTC CLG Study 58881. ( 16358303 )
2007
3
Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation. ( 15973454 )
2005
4
Comparison of radionuclide imaging and ultrasonography in the differentiation of acute testicular torsion and inflammatory testicular disease. ( 12072775 )
2002
5
Testicular disease in childhood B-cell non-Hodgkin's lymphoma: the French Society of Pediatric Oncology experience. ( 11331318 )
2001
6
Overt testicular disease at diagnosis is associated with high risk features and a poor prognosis in patients with childhood acute lymphoblastic leukemia. ( 8941016 )
1996
7
Primary testicular disease presenting as azoospermia or oligozoospermia in an infertility clinic. ( 8102079 )
1993
8
MR imaging in the differential diagnosis of scrotal and testicular disease. ( 1996400 )
1991
9
Contralateral testicular disease after unilateral testicular injury: current concepts. ( 2903525 )
1988
10
Unilateral testicular disease: effect on the contralateral testis (morphometric study). ( 3116283 )
1987
11
Diffuse testicular disease: sonographic features and significance. ( 2998170 )
1985
12
Testicular disease in Singapore children with acute leukemia. ( 6595957 )
1984
13
Exocrine and endocrine testicular function in patients with unilateral testicular disease. ( 6136609 )
1983
14
Computed tomography in testicular disease: a review. ( 7019438 )
1981
15
Testicular disease in acute lymphoblastic leukaemia in childhood. Report on behalf of the Medical Research Council's Working Party on leukaemia in childhood. ( 272221 )
1978
16
TESTICULAR DISEASE. ( 14265372 )
1965

Variations for Testicular Disease

Copy number variations for Testicular Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 266734 Y 1 27200000 Chromosomal abnormal ities Testicular failure
2 267190 Y 25400000 27200000 Deletion AZFa Testicular failure
3 267191 Y 25400000 27200000 Deletion AZFb Testicular failure
4 267192 Y 25400000 27200000 Deletion AZFc Testicular failure

Expression for Testicular Disease

Search GEO for disease gene expression data for Testicular Disease.

Pathways for Testicular Disease

Pathways related to Testicular Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.26 SOX9 SRY

GO Terms for Testicular Disease

Cellular components related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJA3 GJB6
2 connexin complex GO:0005922 8.62 GJA3 GJB6

Biological processes related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.72 CATSPER1 EDA SOX9 SRY TWIST1
2 negative regulation of apoptotic process GO:0043066 9.71 CASP3 PROKR1 SOX9 TWIST1
3 response to lipopolysaccharide GO:0032496 9.43 CASP3 GJB6 NOS3
4 positive regulation of epithelial cell migration GO:0010634 9.37 INSL3 SOX9
5 endocardial cushion morphogenesis GO:0003203 9.16 SOX9 TWIST1
6 male sex determination GO:0030238 8.96 SOX9 SRY
7 positive regulation of male gonad development GO:2000020 8.62 SOX9 SRY

Molecular functions related to Testicular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bHLH transcription factor binding GO:0043425 8.62 SOX9 TWIST1

Sources for Testicular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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