MCID: TST026
MIFTS: 44

Testicular Germ Cell Cancer

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Cancer

MalaCards integrated aliases for Testicular Germ Cell Cancer:

Name: Testicular Germ Cell Cancer 12 15
Testicular Germ Cell Tumor 43 71
Testicular Malignant Germ Cell Tumor 71
Testicular Germ Cell Neoplasm 12
Germ Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5557
MeSH 43 C563236
NCIt 49 C8591
UMLS 71 C0855197 C1336708

Summaries for Testicular Germ Cell Cancer

Disease Ontology : 12 A testicular cancer that has material basis in germ cells.

MalaCards based summary : Testicular Germ Cell Cancer, also known as testicular germ cell tumor, is related to gynecomastia and pediatric germ cell cancer. An important gene associated with Testicular Germ Cell Cancer is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Pathways in cancer and TGF-beta Signaling Pathways. The drugs Oxaliplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are endocrine/exocrine gland and limbs/digits/tail

Related Diseases for Testicular Germ Cell Cancer

Diseases in the Testicular Germ Cell Cancer family:

Testicular Malignant Germ Cell Cancer

Diseases related to Testicular Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 30.5 ESR2 ESR1 AR
2 pediatric germ cell cancer 30.5 SPRY4 KITLG DMRT1
3 dysgerminoma 30.4 MIR371A KITLG DMRT1
4 male infertility 30.4 KITLG FSHR ESR2 AR
5 spermatocytoma 30.4 MIR371A DMRT1
6 infertility 30.3 LHCGR FSHR ESR2 AR
7 testicular disease 30.3 SPRY4 KITLG DMRT1 AR
8 hypospadias 30.1 LHCGR ESR2 ESR1 AR
9 estrogen excess 29.9 FSHR ESR2 ESR1
10 testicular cancer 29.7 XIST TERT SPRY4 LHCGR KITLG DMRT1
11 testicular germ cell tumor 29.7 SPRY4 MIR373 MIR372 MIR371A MIR367 KITLG
12 wilms tumor 1 29.5 TERT MIR373 MEG3 ESR1 AR
13 leukemia, acute myeloid 28.9 TERT MIR372 MIR367 MEG3 KITLG ESR1
14 cryptorchidism, unilateral or bilateral 28.8 SPRY4 LHCGR KITLG FSHR ESR2 ESR1
15 germ cell cancer 27.5 TERT SPRY4 RLN1 MIR373 MIR372 MIR371A
16 testicular germ cell tumor 1 12.7
17 pediatric testicular germ cell tumor 12.7
18 testicular germ cell tumor non-seminomatous 12.6
19 testicular malignant germ cell cancer 11.5
20 pigmented villonodular synovitis 11.5
21 seminoma 10.8
22 teratoma 10.5
23 in situ carcinoma 10.5
24 teratocarcinoma 10.5
25 germ cells tumors 10.4
26 rhabdomyosarcoma 10.4
27 dysgerminoma of ovary 10.4 MIR371A KITLG
28 transsexualism 10.4 ESR2 AR
29 embryonal carcinoma 10.4
30 mature teratoma 10.4
31 nonseminomatous germ cell tumor 10.4
32 chromosome 9p deletion syndrome 10.3 RLN1 DMRT1
33 nonmucinous bronchioloalveolar adenocarcinoma 10.3 ESR2 ESR1
34 inguinal hernia 10.3
35 allergic hypersensitivity disease 10.3
36 leydig cell tumor 10.3
37 oncocytic breast carcinoma 10.3 ESR1 AR
38 wolffian duct adenocarcinoma 10.3 ESR1 AR
39 sarcoidosis 1 10.3
40 gonadoblastoma 10.3
41 wilms tumor 5 10.3
42 gonadal dysgenesis 10.3
43 trophoblastic neoplasm 10.3
44 47,xyy 10.3
45 choriocarcinoma 10.2
46 gender identity disorder 10.2 ESR2 ESR1 AR
47 mucinous cystadenofibroma 10.2 LHCGR FSHR
48 bladder cancer 10.2
49 angiosarcoma 10.2
50 respiratory failure 10.2

Graphical network of the top 20 diseases related to Testicular Germ Cell Cancer:



Diseases related to Testicular Germ Cell Cancer

Symptoms & Phenotypes for Testicular Germ Cell Cancer

MGI Mouse Phenotypes related to Testicular Germ Cell Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.91 AR DMRT1 ESR1 ESR2 FSHR KITLG
2 limbs/digits/tail MP:0005371 9.7 AR BLMH ESR1 ESR2 FSHR KITLG
3 neoplasm MP:0002006 9.43 AR ESR1 ESR2 FSHR KITLG TERT
4 reproductive system MP:0005389 9.28 AR DMRT1 ESR1 ESR2 FSHR KITLG

Drugs & Therapeutics for Testicular Germ Cell Cancer

Drugs for Testicular Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 212)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599 43805
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
4
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
5
Acyclovir Approved Phase 3 59277-89-3 2022
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Palivizumab Approved, Investigational Phase 3 188039-54-5
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
10
Ofloxacin Approved Phase 3 82419-36-1 4583
11
Captopril Approved Phase 3 62571-86-2 44093
12
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
13
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
16
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
17
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
18
Ifosfamide Approved Phase 3 3778-73-2 3690
19
Vinblastine Approved Phase 3 865-21-4 13342 241903
20
Histamine Approved, Investigational Phase 3 51-45-6 774
21
Cyproheptadine Approved Phase 3 129-03-3 2913
22
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
23
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
24
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
25
Polyestradiol phosphate Approved Phase 3 28014-46-2
26
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
27
Mycophenolic acid Approved Phase 3 24280-93-1 446541
28 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
29 Antifungal Agents Phase 3
30 Liver Extracts Phase 3
31 Antiparasitic Agents Phase 3
32 Antiprotozoal Agents Phase 3
33 Cola Phase 3
34 Hormone Antagonists Phase 3
35 Immunoglobulins Phase 3
36 Antibodies Phase 3
37 Antioxidants Phase 3
38 sodium thiosulfate Phase 3
39 valacyclovir Phase 3
40 Antibodies, Monoclonal Phase 3
41 Cytochrome P-450 CYP3A Inhibitors Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 3
43
Hydroxyitraconazole Phase 3
44 Steroid Synthesis Inhibitors Phase 3
45 Renal Agents Phase 3
46 Anti-Infective Agents, Urinary Phase 3
47 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
48
protease inhibitors Phase 3
49 Antihypertensive Agents Phase 3
50 HIV Protease Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 135)
# Name Status NCT ID Phase Drugs
1 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
2 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
5 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
7 INTERNATIONAL RANDOMIZED STUDY FOR THE SALVAGE TREATMENT OF GERM CELL TUMOURS Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
8 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
9 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
10 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
11 A Phase III Multicenter Study of Cytomegalovirus Prophylaxis With Valacyclovir for the Prevention of Serious Fungal and Bacterial Infections Among Cytomegalovirus Seronegative Recipients of Cytomegalovirus Seropositive Sx Stem Cell Transplants Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
12 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
13 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
14 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
15 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
16 Music Video and Adolescent/Young Adult Resilience During Transplant Completed NCT00305851 Phase 3
17 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
18 A Randomized Phase III Toxicity Study of Day 2, 3, 8, 15 Short (30 Minute) Versus Day 1, 2, 3 Long (72 Hours) Infusion Bleomycin for Patients With IGCCCG Good Prognosis Germ Cell Tumors, TE3 Completed NCT00324298 Phase 3 cisplatin;etoposide
19 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
20 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
21 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
22 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
23 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
24 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
25 A Randomized Study to Evaluate The Efficacy of Mycophenolate Mofetil Added to The Systemic Immunosuppressive Regimen First Used For Treatment of Chronic Graft-Versus-Host Disease Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
26 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
27 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
28 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
29 Phase II Trial of Temozolomide in Patients With Cisplatin-Refractory Germ Cell Tumors Completed NCT00006043 Phase 2 temozolomide
30 Phase II Study of Paclitaxel Plus Gemcitabine in Refractory Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
31 Phase II Study of Everolimus in Refractory Testicular Germ Cell Cancer. Completed NCT01466231 Phase 2 Everolimus
32 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
33 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
34 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
35 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
36 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
37 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
38 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
39 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
40 Phase II Study Of Arsenic Trioxide In Patients With Refractory Germ Cell Malignancies Completed NCT00036842 Phase 2 arsenic trioxide
41 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
42 INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
43 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
44 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
45 Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
46 PHASE I/II TRIAL OF TAXOL, IFOSFAMIDE, AND CISPLATIN FOR CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH FAVORABLE PROGNOSTIC FEATURES Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
47 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
48 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
49 A Phase I-II Safety, Tolerability And Pharmacokinetic Study Of Ravuconazole For Prophylaxis Of Invasive Fungal Infections In Patients Undergoing Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
50 Vaccine Therapy With Tumor Specific Mutated Ras Peptides and IL-2 or GM-CSF for Adult Patients With Solid Tumors Completed NCT00019331 Phase 2 DetoxPC

Search NIH Clinical Center for Testicular Germ Cell Cancer

Cochrane evidence based reviews: testicular germ cell tumor

Genetic Tests for Testicular Germ Cell Cancer

Anatomical Context for Testicular Germ Cell Cancer

MalaCards organs/tissues related to Testicular Germ Cell Cancer:

40
Testis, Bone, Bone Marrow, Lymph Node, Kidney, Brain, Breast

Publications for Testicular Germ Cell Cancer

Articles related to Testicular Germ Cell Cancer:

(show top 50) (show all 851)
# Title Authors PMID Year
1
Bilateral wunderlich syndrome secondary to synchronous bilateral testicular germ cell tumor. A case report. 61
31641608 2020
2
Diagnosis and Management of Intratubular Germ Cell Neoplasia in Situ: A Systematic Review. 61
31967523 2020
3
Cystic trophoblastic tumor - The effect of chemotherapy in metastatic testicular germ cell tumor to retroperitoneal lymph nodes. 61
32015622 2020
4
MicroRNAs as Appropriate Discriminators in Non-Specific Alpha-Fetoprotein (AFP) Elevation in Testicular Germ Cell Tumor Patients. 61
31906360 2020
5
Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma. 61
31994813 2020
6
Interobserver Agreement in Vascular Invasion Scoring and the Added Value of Immunohistochemistry for Vascular Markers to Predict Disease Relapse in Stage I Testicular Nonseminomas. 61
31490238 2019
7
Is Testicular Germ Cell Cancer Estrogen Dependent? The Role of Endocrine Disrupting Chemicals. 61
31617897 2019
8
Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer. 61
31583820 2019
9
[Knowledge and early detection of testicular germ cell cancer among adolescents and young adults]. 61
31559444 2019
10
Evaluation of Serum Biomarkers (FGF-2, HGF, MIF and PTN) in Patients With Testicular Germ Cell Cancer. 61
31662522 2019
11
The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells. 61
31744479 2019
12
Site of extranodal metastasis impacts survival in patients with testicular germ cell tumors. 61
31355922 2019
13
Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis. 61
31774524 2019
14
Predictors of Loss to Follow-Up Among Pediatric and Adult Hematopoietic Cell Transplantation Survivors: A Report from the Center for International Blood and Marrow Transplant Research. 61
31726205 2019
15
[Relapse surveillance of patients with testicular germ cell tumor]. 61
31495441 2019
16
Infantile synchronous primary bilateral testicular germ cell tumor: a case report and review of the literature. 61
31807430 2019
17
High Endogenous DNA Damage Levels Predict Hematological Toxicity in Testicular Germ Cell Tumor Patients Treated With First-Line Chemotherapy. 61
31281064 2019
18
Aberrant epigenetic inactivation of RASSF1A and MGMT gene and genetic mutations of KRAS, cKIT and BRAF in Indian testicular germ cell tumours. 61
31653608 2019
19
Successful treatment of metachronous contralateral intratubular germ cell neoplasia with partial orchiectomy and low-dose radiation in a patient previously treated for testicular carcinoma. 61
31179623 2019
20
Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study. 61
31676661 2019
21
miR-371a-3p, miR-373-3p and miR-367-3p as Serum Biomarkers in Metastatic Testicular Germ Cell Cancers Before, During and After Chemotherapy. 61
31597402 2019
22
Testicular microlithiasis: Systematic review and Clinical guidelines. 61
31383508 2019
23
Clinicopathologic Characterization of Bilateral Testicular Germ Cell Tumors With Immunohistochemical Evaluation of Mismatch Repair and BRAF (V600E) Genes Mutations. 61
30983459 2019
24
Laparoscopic Bilateral Gonadectomy and Inguinal Hernia Repair with Mesh for Complete Androgen Insensitivity Syndrome: A Case Report. 61
30825542 2019
25
Robot-assisted laparoscopic retroperitoneal lymph node dissection with concomitant inferior vena cava thrombectomy for metastatic mixed testicular germ cell cancer: a case report. 61
31451109 2019
26
Testicular germ cell cancer: recent developments in biology and clinical management. 61
31310059 2019
27
Spontaneous gas in a retroperitoneal mass: check the testis! 61
31038859 2019
28
Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation. 61
30786164 2019
29
Trend analysis and regional tumor incidence in Germany for testicular cancer between 2003 and 2014. 61
31310057 2019
30
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. 61
29579225 2019
31
Comprehensive characterization of cancer-testis genes in testicular germ cell tumor. 61
31070303 2019
32
Testicular Germ Cell Tumor Showing Concurrent PNET and Neuroglial Neoplasms With Wide Spectrum of Grades. 61
31091205 2019
33
A case of cervical spinal mass with cord compression and rib bone metastasis from presumably burned-out seminomatous testicular germ cell tumor. 61
31180313 2019
34
Intraoperative tumor lysis syndrome in a giant teratoma: a case report. 61
31200669 2019
35
Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study. 61
31163029 2019
36
MRI in the Follow-up of Testicular Cancer: Less is More. 61
31177136 2019
37
Current pharmacotherapy for testicular germ cell cancer. 61
30849243 2019
38
Prognostic and predictive factors in testicular cancer. 61
31115016 2019
39
cd44 deletion suppresses atypia in the precancerous mouse testis. 61
30582228 2019
40
Is gynecomastia related to the disease characteristics and prognosis in testicular germ cell tumor patients? 61
31063146 2019
41
Testicular germ cell tumor: a comprehensive review. 61
30671589 2019
42
Testicular mixed germ cell tumor presenting with seizure as the initial symptom: a case report and literature review. 61
30912892 2019
43
Late and Rapid Relapse in Mediastinum from Testicular Germ Cell Tumor Stage I Over 13 Years after Surgery. 61
31320874 2019
44
Srlp is crucial for the self-renewal and differentiation of germline stem cells via RpL6 signals in Drosophila testes. 61
30931935 2019
45
Paper-based immunocapture for targeted protein analysis. 61
30625614 2019
46
Re: Risk of Solid Cancer after Treatment of Testicular Germ Cell Cancer in the Platinum Era. 61
30759676 2019
47
Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis. 61
30900623 2019
48
Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma. 61
30266250 2019
49
Cytokeratin 7, inhibin, and p63 in testicular germ cell tumor: superior markers of choriocarcinoma compared to β-human chorionic gonadotropin. 61
30359635 2019
50
Immunotherapy: last bullet in platinum refractory germ cell testicular cancer. 61
30624089 2019

Variations for Testicular Germ Cell Cancer

Expression for Testicular Germ Cell Cancer

Search GEO for disease gene expression data for Testicular Germ Cell Cancer.

Pathways for Testicular Germ Cell Cancer

Pathways related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.38 TERT KITLG ESR2 ESR1 AR
2 11.56 ESR2 ESR1 AR
3
Show member pathways
11.45 ESR2 ESR1 AR
4 11.03 MIR373 MIR372 MIR371A
5 10.48 LHCGR FSHR
6 10.3 LHCGR FSHR ESR2
7 9.56 ESR2 ESR1

GO Terms for Testicular Germ Cell Cancer

Biological processes related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 sex differentiation GO:0007548 9.49 DMRT1 AR
2 intracellular estrogen receptor signaling pathway GO:0030520 9.48 ESR2 ESR1
3 uterus development GO:0060065 9.46 FSHR ESR1
4 mammary gland alveolus development GO:0060749 9.43 ESR1 AR
5 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.4 FSHR ESR1
6 regulation of systemic arterial blood pressure GO:0003073 9.37 FSHR AR
7 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.33 LHCGR FSHR ESR1
8 positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 9.32 FSHR AR
9 Sertoli cell development GO:0060009 9.26 FSHR DMRT1
10 male gonad development GO:0008584 9.1 LHCGR KITLG FSHR ESR1 DMRT1 AR
11 ovulation cycle process GO:0022602 8.96 LHCGR FSHR

Molecular functions related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.5 ESR2 ESR1 AR
2 transcription coactivator binding GO:0001223 9.4 TERT ESR1
3 protein-hormone receptor activity GO:0016500 9.37 LHCGR FSHR
4 nuclear receptor activity GO:0004879 9.33 ESR2 ESR1 AR
5 estrogen receptor activity GO:0030284 9.26 ESR2 ESR1
6 estrogen response element binding GO:0034056 8.96 ESR2 ESR1
7 steroid binding GO:0005496 8.8 ESR2 ESR1 AR

Sources for Testicular Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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