MCID: TST026
MIFTS: 41

Testicular Germ Cell Cancer

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Cancer

MalaCards integrated aliases for Testicular Germ Cell Cancer:

Name: Testicular Germ Cell Cancer 12 15
Testicular Germ Cell Tumor 44 73
Testicular Malignant Germ Cell Tumor 73
Testicular Germ Cell Neoplasm 12
Germ Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5557
MeSH 44 C563236
NCIt 50 C8591
SNOMED-CT 68 713577007
UMLS 73 C1336708

Summaries for Testicular Germ Cell Cancer

Disease Ontology : 12 A testicular cancer that has material basis in germ cells.

MalaCards based summary : Testicular Germ Cell Cancer, also known as testicular germ cell tumor, is related to testicular germ cell tumor and testicular germ cell tumor 1. An important gene associated with Testicular Germ Cell Cancer is XIST (X Inactive Specific Transcript
XIST expression was common in seminomatous testicular germ cell tumors (2 of 2 or 100% of seminoma derived cell lineand 10 of 12 or 83% of seminomatous testicular germ cell tumor tissues) but not in nonseminomatous testicular germ cell tumors (0 of 2 or 0% nonseminoma derived cell lineand 2 of 8 or 25% of nonseminomatous testicular germ cell tumor tissues). The current data may suggest the potential oncogenic implications of X chromosomal gain in testicular germ cell tumors.
Dysfunction Pattern: Regulation [up-regulated]), and among its related pathways/superpathways is Coregulation of Androgen receptor activity. The drugs Cisplatin and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testis.

Related Diseases for Testicular Germ Cell Cancer

Graphical network of the top 20 diseases related to Testicular Germ Cell Cancer:



Diseases related to Testicular Germ Cell Cancer

Symptoms & Phenotypes for Testicular Germ Cell Cancer

Drugs & Therapeutics for Testicular Germ Cell Cancer

Drugs for Testicular Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 307)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Phase 3 5949-44-0
4
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3 58-22-0 6013
5
Methyltestosterone Approved Phase 4,Phase 2,Phase 3 58-18-4 6010
6
Testosterone enanthate Approved Phase 4,Phase 2,Phase 3 315-37-7 9416
7 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
8
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
9
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
10 interferons Phase 4,Phase 1,Phase 2
11 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
12 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
13 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
16 Anabolic Agents Phase 4,Phase 2,Phase 3
17 Testosterone 17 beta-cypionate Phase 4,Phase 2,Phase 3
18 Androgens Phase 4,Phase 2,Phase 3
19 Interferon Inducers Phase 4,Phase 1,Phase 2
20 Follicle Stimulating Hormone Phase 4
21 Estradiol 17 beta-cypionate Phase 4,Phase 3
22 Estradiol 3-benzoate Phase 4,Phase 3
23
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
24
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
25
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
26
Vinblastine Approved Phase 3 865-21-4 13342 241903
27
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
28
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
29
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
30
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
31
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 50-02-2 5743
32
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
33
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
34
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
35
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
36
Ribavirin Approved Phase 3 36791-04-5 37542
37
Captopril Approved Phase 3 62571-86-2 44093
38
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
39
Ofloxacin Approved Phase 3 82419-36-1 4583
40
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
41
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
42
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
43
Acyclovir Approved Phase 3 59277-89-3 2022
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
45
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
46
Palivizumab Approved, Investigational Phase 3 188039-54-5
47
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
48
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
49
Promethazine Approved, Investigational Phase 3 60-87-7 4927
50
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946

Interventional clinical trials:

(show top 50) (show all 287)
# Name Status NCT ID Phase Drugs
1 Taste, Smell and Chemotherapy (TASTY) Completed NCT01641172 Phase 4
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
5 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
6 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
8 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
9 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
10 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
11 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
12 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
13 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
14 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
15 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
16 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
17 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
18 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
19 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
20 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
21 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
22 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
23 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
24 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
25 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
26 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
27 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
28 Study of Testosterone vs Placebo in Testicular Cancer Survivors Recruiting NCT02991209 Phase 2, Phase 3 Testosterone;Placebos
29 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
30 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
31 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
32 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
33 Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate Active, not recruiting NCT01444820 Phase 3
34 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
35 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
36 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
37 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
38 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
39 Peptide Vaccination in Treating Patients With Esophageal Cancer (STF-II) Unknown status NCT01267578 Phase 2
40 A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer Unknown status NCT00995358 Phase 2
41 Phase II Study of S-488410 to Treat Non-small Cell Lung Cancer Unknown status NCT01592617 Phase 2 S-488410
42 Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*02 Disease Controlled Advanced Non-small Cell Lung Cancer Unknown status NCT01949701 Phase 1, Phase 2
43 Sutent and Radiation as Treatment for Limited Extent Metastatic Cancer Unknown status NCT00463060 Phase 1, Phase 2 sunitinib malate (Sutent)
44 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
45 Promotora-based Latino Family CVD Risk Reduction Unknown status NCT01714271 Phase 2
46 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
47 Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor Unknown status NCT02784054 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin;Thiotepa;Melphalan
48 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
49 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
50 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide

Search NIH Clinical Center for Testicular Germ Cell Cancer

Cochrane evidence based reviews: testicular germ cell tumor

Genetic Tests for Testicular Germ Cell Cancer

Anatomical Context for Testicular Germ Cell Cancer

MalaCards organs/tissues related to Testicular Germ Cell Cancer:

41
Bone, Bone Marrow, Testis, T Cells, Lung, Lymph Node, Brain

Publications for Testicular Germ Cell Cancer

Articles related to Testicular Germ Cell Cancer:

(show top 50) (show all 117)
# Title Authors Year
1
Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology. ( 29530636 )
2018
2
Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer? ( 29179257 )
2018
3
microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. ( 28612337 )
2017
4
Cisplatin-related Cerebral Infarction in Testicular Germ Cell Cancer: Short Report of Three Cases and P in testicular germ cell cancer: Short report of three cases and pathomechanism. ( 27923208 )
2017
5
Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality. ( 28591464 )
2017
6
Animacroxam, a novel dual-mode compound targeting histone deacetylases and cytoskeletal integrity of testicular germ cell cancer cells. ( 28838999 )
2017
7
A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer. ( 26871895 )
2016
8
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review. ( 27821802 )
2016
9
Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment. ( 27873769 )
2016
10
Increasing international efforts to understand and conquer testicular germ cell cancer. ( 25711179 )
2015
11
Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship. ( 25751759 )
2015
12
Re: Yvonne Vergouwe, Ewout W. Steyerberg, Richard S. Foster, et al. Predicting Retroperitoneal Histology in Postchemotherapy Testicular Germ Cell Cancer: A Model Update and Multicentre Validation with More Than 1000 Patients. Eur Urol 2007;51:424-32. ( 26726125 )
2015
13
Reply to Nahid Punjani, Nicholas Power, Eric Winquist's Letter to the Editor re: Yvonne Vergouwe, Ewout W. Steyerberg, Richard S. Foster, et al. Predicting Retroperitoneal Histology in Postchemotherapy Testicular Germ Cell Cancer: A Model Update and Multicentre Validation with More Than 1000 Patients. Eur Urol 2007;51:424-32. ( 26726124 )
2015
14
Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts. ( 25826226 )
2015
15
Surveillance policy for Japanese patients with stage I testicular germ cell cancer in the multi-detector computed tomography era. ( 25893862 )
2015
16
Salvage chemotherapy with gemcitabine plus oxaliplatin for patients with testicular germ cell cancer. ( 24647526 )
2014
17
Trends in testicular germ cell cancer incidence in Eastern Croatia. ( 24496357 )
2014
18
An oncofetal and developmental perspective on testicular germ cell cancer. ( 25066859 )
2014
19
Changes in epidemiologic features of testicular germ cell cancer: Age at diagnosis and relative frequency of seminoma are constantly and significantly increasing. ( 23395239 )
2014
20
Circulating Serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as Biomarkers in Patients with Testicular Germ Cell Cancer. ( 25046619 )
2014
21
Nodal, pulmonary and pleural gliomatosis in a 42-year-old-male with non-seminomatous testicular germ cell cancer. ( 24444134 )
2014
22
Thrombocytopenia following high-dose chemotherapy with carboplatin, etoposide and thiotepa in patients with testicular germ cell cancer. ( 23260006 )
2013
23
Expression analysis of RNA-binding motif gene on Y chromosome (RBMY) protein isoforms in testis tissue and a testicular germ cell cancer-derived cell line (NT2). ( 23567846 )
2013
24
Just another brick in the wall: unravelling the epigenetic mechanism underlying tumour initiation of testicular germ cell cancer. ( 24292446 )
2013
25
Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer. ( 23420531 )
2013
26
Re: Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. ( 24120784 )
2013
27
Sperm concentration, testicular volume and age predict risk of carcinoma in situ in contralateral testis of men with testicular germ cell cancer. ( 23770148 )
2013
28
Influence of vitamin D on cisplatin sensitivity in testicular germ cell cancer-derived cell lines and in a NTera2 xenograft model. ( 23098692 )
2013
29
Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle. ( 24012110 )
2013
30
Changing epidemiologic features of testicular germ cell cancer in Germany: corroboration at population level. ( 24035419 )
2013
31
Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. ( 23372565 )
2013
32
Replication of genetic susceptibility loci for testicular germ cell cancer in the Croatian population. ( 22745383 )
2012
33
Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. ( 23169338 )
2012
34
Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. ( 22245602 )
2012
35
Variants in KITLG predispose to testicular germ cell cancer independently from spermatogenic function. ( 22194441 )
2012
36
Is testicular germ cell cancer associated with increased muscle mass or adiposity? ( 21253772 )
2011
37
Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information. ( 21696394 )
2011
38
Development of testicular germ cell cancer following successful infliximab induction therapy for ulcerative colitis. ( 21453887 )
2011
39
Perinatal risk factors for childhood testicular germ-cell cancer: a Nordic population-based study. ( 21846595 )
2011
40
Interdisciplinary evidence-based recommendations for the follow-up of testicular germ cell cancer patients. ( 21346388 )
2011
41
Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease. ( 20880698 )
2011
42
Interdisciplinary evidence-based recommendations for the follow-up of early stage seminomatous testicular germ cell cancer patients. ( 21347634 )
2011
43
Testosterone deficiency in testicular germ-cell cancer patients is not influenced by oncological treatment. ( 21062302 )
2011
44
Canadian consensus guidelines for the management of testicular germ cell cancer. ( 20368885 )
2010
45
Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003. ( 20171682 )
2010
46
Burden or relief: do second-opinion centers influence the quality of care delivered to patients with testicular germ cell cancer? ( 19931248 )
2010
47
Current status of chemotherapy in risk-adapted management for metastatic testicular germ cell cancer. ( 19922501 )
2010
48
Familial coaggregation of cryptorchidism, hypospadias, and testicular germ cell cancer: a nationwide cohort study. ( 20026812 )
2010
49
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. ( 20543847 )
2010
50
Is increased body mass index associated with the incidence of testicular germ cell cancer? ( 19002497 )
2009

Variations for Testicular Germ Cell Cancer

Expression for Testicular Germ Cell Cancer

Search GEO for disease gene expression data for Testicular Germ Cell Cancer.

Pathways for Testicular Germ Cell Cancer

Pathways related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.38 AR PIAS1

GO Terms for Testicular Germ Cell Cancer

Biological processes related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 AR DMRT1 ESR2 PIAS1
2 steroid hormone mediated signaling pathway GO:0043401 9.32 AR ESR2
3 androgen receptor signaling pathway GO:0030521 9.16 AR PIAS1
4 sex differentiation GO:0007548 8.96 AR DMRT1
5 male gonad development GO:0008584 8.8 AR DMRT1 KITLG

Molecular functions related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.5 AR ESR2 PIAS1
2 zinc ion binding GO:0008270 9.46 ALPP AR ESR2 PIAS1
3 steroid hormone receptor activity GO:0003707 9.26 AR ESR2
4 nuclear receptor activity GO:0004879 8.96 AR ESR2
5 steroid binding GO:0005496 8.62 AR ESR2

Sources for Testicular Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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