MCID: TST026
MIFTS: 40

Testicular Germ Cell Cancer

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Cancer

MalaCards integrated aliases for Testicular Germ Cell Cancer:

Name: Testicular Germ Cell Cancer 12 15
Testicular Germ Cell Tumor 44 72
Testicular Malignant Germ Cell Tumor 72
Testicular Germ Cell Neoplasm 12
Germ Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5557
MeSH 44 C563236
NCIt 50 C8591
UMLS 72 C0855197 C1336708

Summaries for Testicular Germ Cell Cancer

Disease Ontology : 12 A testicular cancer that has material basis in germ cells.

MalaCards based summary : Testicular Germ Cell Cancer, also known as testicular germ cell tumor, is related to germ cell cancer and testicular germ cell tumor. An important gene associated with Testicular Germ Cell Cancer is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways is Coregulation of Androgen receptor activity. The drugs Oxaliplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotype is limbs/digits/tail.

Related Diseases for Testicular Germ Cell Cancer

Diseases in the Testicular Germ Cell Cancer family:

Testicular Malignant Germ Cell Cancer

Diseases related to Testicular Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 germ cell cancer 30.8 SPRY4 KITLG ESR2 DMRT1 AR
2 testicular germ cell tumor 29.7 SPRY4 MIR372 KITLG DMRT1 AR
3 leukemia, acute myeloid 29.0 MIR372 MEG3 KITLG
4 prostate cancer 27.4 XIST SPRY4-IT1 MEG3 ESR2 AR
5 testicular germ cell tumor 1 12.7
6 pediatric testicular germ cell tumor 12.7
7 testicular germ cell tumor non-seminomatous 12.6
8 testicular malignant germ cell cancer 11.5
9 pigmented villonodular synovitis 11.5
10 testicular cancer 10.8
11 seminoma 10.8
12 teratoma 10.5
13 in situ carcinoma 10.5
14 teratocarcinoma 10.5
15 germ cells tumors 10.4
16 rhabdomyosarcoma 10.4
17 postmenopausal atrophic vaginitis 10.4 ESR2 AR
18 vaginitis 10.4 ESR2 AR
19 gender identity disorder 10.4 ESR2 AR
20 transsexualism 10.4 ESR2 AR
21 embryonal carcinoma 10.4
22 mature teratoma 10.4
23 nonseminomatous germ cell tumor 10.4
24 infertility 10.3
25 wilms tumor 1 10.3
26 inguinal hernia 10.3
27 allergic hypersensitivity disease 10.3
28 leydig cell tumor 10.3
29 47,xyy 10.3
30 prostatic hyperplasia, benign 10.3 ESR2 AR
31 oligospermia 10.3 KITLG AR
32 male infertility 10.3
33 sarcoidosis 1 10.3
34 gonadoblastoma 10.3
35 wilms tumor 5 10.3
36 gonadal dysgenesis 10.3
37 cryptorchidism, unilateral or bilateral 10.2
38 choriocarcinoma 10.2
39 bladder cancer 10.2
40 angiosarcoma 10.2
41 respiratory failure 10.2
42 infant gynecomastia 10.2
43 neutropenia 10.2
44 gynecomastia 10.2
45 trophoblastic neoplasm 10.2
46 pulmonary embolism 10.2
47 alopecia 10.2
48 teratoma with malignant transformation 10.2
49 argyria 10.2
50 body mass index quantitative trait locus 1 10.1

Graphical network of the top 20 diseases related to Testicular Germ Cell Cancer:



Diseases related to Testicular Germ Cell Cancer

Symptoms & Phenotypes for Testicular Germ Cell Cancer

MGI Mouse Phenotypes related to Testicular Germ Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 AR BLMH ESR2 KITLG SPRY4

Drugs & Therapeutics for Testicular Germ Cell Cancer

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Ifosfamide Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma. DB01181

Drugs for Testicular Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 217)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
4
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
5
Ribavirin Approved Phase 3 36791-04-5 37542
6
Palivizumab Approved, Investigational Phase 3 188039-54-5
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Ofloxacin Approved Phase 3 82419-36-1 4583
9
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
10
Captopril Approved Phase 3 62571-86-2 44093
11
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
12
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
13
Acyclovir Approved Phase 3 59277-89-3 2022
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
16
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
17
Ifosfamide Approved Phase 3 3778-73-2 3690
18
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20
Histamine Approved, Investigational Phase 3 51-45-6 774
21
Cyproheptadine Approved Phase 3 129-03-3 2913
22
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
23
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
24
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
25
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
26
Polyestradiol phosphate Approved Phase 3 28014-46-2
27
Mycophenolic acid Approved Phase 3 24280-93-1 446541
28 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
29 Antirheumatic Agents Phase 3
30 Antifungal Agents Phase 3
31 Hormone Antagonists Phase 3
32 Peripheral Nervous System Agents Phase 3
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
34 Cola Phase 3
35 Liver Extracts Phase 3
36 Antibodies Phase 3
37 Immunoglobulins Phase 3
38 sodium thiosulfate Phase 3
39 Antioxidants Phase 3
40 HIV Protease Inhibitors Phase 3
41
protease inhibitors Phase 3
42 Antibodies, Monoclonal Phase 3
43 14-alpha Demethylase Inhibitors Phase 3
44 Cytochrome P-450 CYP3A Inhibitors Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3
46 Steroid Synthesis Inhibitors Phase 3
47
Hydroxyitraconazole Phase 3
48 Renal Agents Phase 3
49 Anti-Infective Agents, Urinary Phase 3
50 Cytochrome P-450 CYP1A2 Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 131)
# Name Status NCT ID Phase Drugs
1 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
2 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
5 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
7 INTERNATIONAL RANDOMIZED STUDY FOR THE SALVAGE TREATMENT OF GERM CELL TUMOURS Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
8 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
9 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
10 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
11 Music Video and Adolescent/Young Adult Resilience During Transplant Completed NCT00305851 Phase 3
12 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
13 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
14 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
15 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
16 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
17 A Randomized Phase III Toxicity Study of Day 2, 3, 8, 15 Short (30 Minute) Versus Day 1, 2, 3 Long (72 Hours) Infusion Bleomycin for Patients With IGCCCG Good Prognosis Germ Cell Tumors, TE3 Completed NCT00324298 Phase 3 cisplatin;etoposide
18 A Phase III Multicenter Study of Cytomegalovirus Prophylaxis With Valacyclovir for the Prevention of Serious Fungal and Bacterial Infections Among Cytomegalovirus Seronegative Recipients of Cytomegalovirus Seropositive Sx Stem Cell Transplants Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
19 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
20 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
21 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
22 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
23 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
24 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
25 A Randomized Study to Evaluate The Efficacy of Mycophenolate Mofetil Added to The Systemic Immunosuppressive Regimen First Used For Treatment of Chronic Graft-Versus-Host Disease Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
26 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
27 Effectiveness of an Individualized Program of Muscular Strength and Endurance Program With Aerobic Training for Improving Germ Cell Cancer Related Fatigue in Men Undergoing Chemotherapy Unknown status NCT02433197 Phase 1, Phase 2
28 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
29 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
30 Phase II Trial of Temozolomide in Patients With Cisplatin-Refractory Germ Cell Tumors Completed NCT00006043 Phase 2 temozolomide
31 Phase II Study of Paclitaxel Plus Gemcitabine in Refractory Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
32 Phase II Study of Everolimus in Refractory Testicular Germ Cell Cancer. Completed NCT01466231 Phase 2 Everolimus
33 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
34 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
35 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
36 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
37 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
38 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
39 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
40 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
41 Phase II Study Of Arsenic Trioxide In Patients With Refractory Germ Cell Malignancies Completed NCT00036842 Phase 2 arsenic trioxide
42 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
43 INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
44 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
45 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
46 PHASE I/II TRIAL OF TAXOL, IFOSFAMIDE, AND CISPLATIN FOR CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH FAVORABLE PROGNOSTIC FEATURES Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
47 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
48 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
49 Vaccine Therapy With Tumor Specific Mutated Ras Peptides and IL-2 or GM-CSF for Adult Patients With Solid Tumors Completed NCT00019331 Phase 2 DetoxPC
50 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate

Search NIH Clinical Center for Testicular Germ Cell Cancer

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ifosfamide

Cochrane evidence based reviews: testicular germ cell tumor

Genetic Tests for Testicular Germ Cell Cancer

Anatomical Context for Testicular Germ Cell Cancer

MalaCards organs/tissues related to Testicular Germ Cell Cancer:

41
Testis, Bone, Bone Marrow, Brain, Lymph Node, Liver, Lung

Publications for Testicular Germ Cell Cancer

Articles related to Testicular Germ Cell Cancer:

(show top 50) (show all 829)
# Title Authors PMID Year
1
Clinicopathologic Characterization of Bilateral Testicular Germ Cell Tumors With Immunohistochemical Evaluation of Mismatch Repair and BRAF (V600E) Genes Mutations. 38
30983459 2019
2
Testicular microlithiasis: Systematic review and Clinical guidelines. 38
31383508 2019
3
Spontaneous gas in a retroperitoneal mass: check the testis! 38
31038859 2019
4
Site of extranodal metastasis impacts survival in patients with testicular germ cell tumors. 38
31355922 2019
5
Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation. 38
30786164 2019
6
Trend analysis and regional tumor incidence in Germany for testicular cancer between 2003 and 2014. 38
31310057 2019
7
Comprehensive characterization of cancer-testis genes in testicular germ cell tumor. 38
31070303 2019
8
Testicular germ cell cancer: recent developments in biology and clinical management. 38
31310059 2019
9
Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study. 38
31163029 2019
10
MRI in the Follow-up of Testicular Cancer: Less is More. 38
31177136 2019
11
Testicular Germ Cell Tumor Showing Concurrent PNET and Neuroglial Neoplasms With Wide Spectrum of Grades. 38
31091205 2019
12
High Endogenous DNA Damage Levels Predict Hematological Toxicity in Testicular Germ Cell Tumor Patients Treated With First-Line Chemotherapy. 38
31281064 2019
13
A case of cervical spinal mass with cord compression and rib bone metastasis from presumably burned-out seminomatous testicular germ cell tumor. 38
31180313 2019
14
Intraoperative tumor lysis syndrome in a giant teratoma: a case report. 38
31200669 2019
15
Successful treatment of metachronous contralateral intratubular germ cell neoplasia with partial orchiectomy and low-dose radiation in a patient previously treated for testicular carcinoma. 38
31179623 2019
16
cd44 deletion suppresses atypia in the precancerous mouse testis. 38
30582228 2019
17
Prognostic and predictive factors in testicular cancer. 38
31115016 2019
18
Late and Rapid Relapse in Mediastinum from Testicular Germ Cell Tumor Stage I Over 13 Years after Surgery. 38
31320874 2019
19
Is gynecomastia related to the disease characteristics and prognosis in testicular germ cell tumor patients? 38
31063146 2019
20
Testicular germ cell tumor: a comprehensive review. 38
30671589 2019
21
Testicular mixed germ cell tumor presenting with seizure as the initial symptom: a case report and literature review. 38
30912892 2019
22
Current pharmacotherapy for testicular germ cell cancer. 38
30849243 2019
23
Paper-based immunocapture for targeted protein analysis. 38
30625614 2019
24
Srlp is crucial for the self-renewal and differentiation of germline stem cells via RpL6 signals in Drosophila testes. 38
30931935 2019
25
Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis. 38
30900623 2019
26
Re: Risk of Solid Cancer after Treatment of Testicular Germ Cell Cancer in the Platinum Era. 38
30759676 2019
27
Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development. 38
30739914 2019
28
Re: MicroRNA-371a-3p as Informative Biomarker for the Follow-up of Testicular Germ Cell Cancer Patients. 38
30634340 2019
29
Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours. 38
30518631 2019
30
Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma. 38
30266250 2019
31
Cytokeratin 7, inhibin, and p63 in testicular germ cell tumor: superior markers of choriocarcinoma compared to β-human chorionic gonadotropin. 38
30359635 2019
32
Laparoscopic Bilateral Gonadectomy and Inguinal Hernia Repair with Mesh for Complete Androgen Insensitivity Syndrome: A Case Report. 38
30825542 2019
33
Immunotherapy: last bullet in platinum refractory germ cell testicular cancer. 38
30624089 2019
34
New Anti-Cancer Strategies in Testicular Germ Cell Tumors. 38
30636617 2019
35
Testicular Cancer-Surgical Treatment. 38
31156556 2019
36
Role of Viral Infections in Testicular Cancer Etiology: Evidence From a Systematic Review and Meta-Analysis. 38
31263452 2019
37
Identification of key genes and pathways in seminoma by bioinformatics analysis. 38
31190870 2019
38
Spontaneous regression as a 'burned-out' non-seminomatous testicular germ cell tumor: a case report and literature review. 38
30647899 2019
39
Association between male pattern baldness and testicular germ cell tumor: a meta-analysis. 38
30634927 2019
40
Mature Cystic Teratoma of the Lung With a Somatic-Like Malignant Component in a Patient With Testicular Germ-Cell Tumor. 38
30041955 2018
41
Protein expression of the transcription factors DMRT1, TCLF5, and OCT4 in selected germ cell neoplasms of the testis. 38
30067948 2018
42
Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart. 38
30593757 2018
43
[French ccAFU guidelines - Update 2018-2020: Testicular germ cell tumors]. 38
30472999 2018
44
Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis. 38
30428358 2018
45
[French ccAFU guidelines - Update 2018-2020: Penile cancer]. 38
30361138 2018
46
Sperm imprinting integrity in seminoma patients? 38
30340650 2018
47
Re: Identification of 19 New Risk Loci and Potential Regulatory Mechanisms Influencing Susceptibility to Testicular Germ Cell Tumor. 38
30227584 2018
48
MiR-371a-3p Serum Levels Are Increased in Recurrence of Testicular Germ Cell Tumor Patients. 38
30321995 2018
49
Characteristics, treatment decisions and outcomes of prepubertal testicular germ cell tumor: A descriptive analysis from a large Chinese center. 38
29705139 2018
50
A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth. 38
30237497 2018

Variations for Testicular Germ Cell Cancer

Expression for Testicular Germ Cell Cancer

Search GEO for disease gene expression data for Testicular Germ Cell Cancer.

Pathways for Testicular Germ Cell Cancer

Pathways related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.38 PIAS1 AR

GO Terms for Testicular Germ Cell Cancer

Biological processes related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 PIAS1 ESR2 DMRT1 AR
2 androgen receptor signaling pathway GO:0030521 9.16 PIAS1 AR
3 sex differentiation GO:0007548 8.96 DMRT1 AR
4 male gonad development GO:0008584 8.8 KITLG DMRT1 AR

Molecular functions related to Testicular Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.16 ESR2 AR
2 nuclear receptor activity GO:0004879 8.96 ESR2 AR
3 steroid binding GO:0005496 8.62 ESR2 AR

Sources for Testicular Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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