MCID: TST021
MIFTS: 61

Testicular Germ Cell Tumor

Categories: Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Testicular Germ Cell Tumor

MalaCards integrated aliases for Testicular Germ Cell Tumor:

Name: Testicular Germ Cell Tumor 57 53 75 73
Spermatocytic Seminoma 59 75 73
Male Germ Cell Tumor 57 75 73
Germ Cell Tumor, Nonseminomatous 29 6
Spermatocytic Seminoma, Somatic 57 6
Male Germ Cell Tumor, Somatic 57 6
Embryonal Cell Carcinoma 75 73
Endodermal Sinus Tumor 59 75
Testicular Teratoma 59 55
Yolk Sac Tumor 59 73
Seminoma 75 73
Tgct 57 75
Mgct 57 75
Malignant Testicular Non-Seminomatous Germ Cell Tumor 73
Testicular Non-Dysgerminomatous Germ Cell Tumor 59
Non-Dysgerminomatous Germ Cell Tumor of Testis 59
Testicular Non Seminomatous Germ Cell Tumor 59
Testicular Non-Seminomatous Germ Cell Tumor 73
Non-Seminomatous Germ Cell Tumor of Testis 59
Testicular Seminomatous Germ Cell Tumor 59
Seminomatous Germ Cell Tumor of Testis 59
Nonseminomatous Germ Cell Tumors 75
Nonseminomatous Germ Cell Tumor 73
Tumor, Germ Cell, Testicular 40
Male Germ Cell Tumor; Mgct 57
Germ Cell Tumors, Somatic 57
Testicular Tumor, Somatic 57
Germ Cell Tumor of Testis 53
Teratoma of the Testis 59
Testicular Seminoma 59
Teratoma Testicular 75
Seminoma of Testis 59
Teratoma of Testis 73

Characteristics:

Orphanet epidemiological data:

59
testicular seminomatous germ cell tumor
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe); Age of onset: Adult; Age of death: adult,elderly,young Adult;
non-seminomatous germ cell tumor of testis
Prevalence: 1-9/100000 (Europe),1-5/10000 (Europe);
testicular teratoma
Prevalence: <1/1000000 (Europe);
spermatocytic seminoma
Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
somatic mutation

Miscellaneous:
two subtypes - seminoma and nonseminoma
occasionally germ cell tumor arise from extra gonadal site (e.g., mediastinum, retroperitoneum, pineal gland)
most common cancer in men aged 15-40 years
highest incidence in men of european descent
risk factors for development of tgct - family history, cryptorchidism , testicular feminization , klinefelter syndrome, previous tgct, gonadal dysgenesis


HPO:

32
testicular germ cell tumor:
Inheritance somatic mutation sporadic


Classifications:

Orphanet: 59  
Rare urogenital diseases


Summaries for Testicular Germ Cell Tumor

OMIM : 57 Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold. This familial relative risk is much higher than that for most other types of cancer (summary by Rapley et al., 2000). (273300)

MalaCards based summary : Testicular Germ Cell Tumor, also known as spermatocytic seminoma, is related to spermatocytoma and seminoma. An important gene associated with Testicular Germ Cell Tumor is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are MicroRNAs in cancer and miRNAs involved in DNA damage response. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are cryptorchidism and gonadal dysgenesis

UniProtKB/Swiss-Prot : 75 Testicular germ cell tumor: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.

Related Diseases for Testicular Germ Cell Tumor

Diseases in the Testicular Germ Cell Tumor family:

Testicular Germ Cell Tumor 1

Diseases related to Testicular Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 spermatocytoma 34.2 DMRT1 FGFR3 KIT
2 seminoma 31.7 AFP FGFR3 KIT
3 teratoma 31.5 AFP DMRT1 KIT
4 intratubular embryonal carcinoma 31.1 AFP KIT
5 mature teratoma 30.7 AFP BRAF
6 adenocarcinoma 30.4 BRAF FGFR3 KIT STK11
7 lung cancer 26.3 BRAF KIT MIR133B MIR140 MIR145 MIR200C
8 testicular germ cell tumor 1 12.5
9 nonseminomatous germ cell tumor 12.5
10 testicular yolk sac tumor 12.5
11 extragonadal nonseminomatous germ cell tumor 12.4
12 testicular spermatocytic seminoma 12.4
13 vaginal yolk sac tumor 12.4
14 yolk sac tumor of central nervous system 12.4
15 pediatric testicular germ cell tumor 12.4
16 pineal region yolk sac tumor 12.2
17 glandular pattern ovarian yolk sac tumor 12.2
18 macrocystic pattern testicular yolk sac tumor 12.2
19 solid pattern testicular yolk sac tumor 12.2
20 glandular-alveolar pattern testicular yolk sac tumor 12.2
21 myxomatous pattern testicular yolk sac tumor 12.2
22 papillary pattern testicular yolk sac tumor 12.2
23 enteric pattern testicular yolk sac tumor 12.2
24 reticular pattern testicular yolk sac tumor 12.2
25 endodermal sinus tumor 12.2
26 testicular germ cell tumor non-seminomatous 12.2
27 hepatoid pattern ovarian yolk sac tumor 12.2
28 polyvesicular vitelline pattern ovarian yolk sac tumor 12.2
29 endodermal sinus pattern testicular yolk sac tumor 12.2
30 polyvesicular vitelline pattern testicular yolk sac tumor 12.2
31 hepatoid pattern testicular yolk sac tumor 12.2
32 pediatric cns embryonal cell carcinoma 12.1
33 testicular seminoma 11.5
34 testicular germ cell cancer 11.3
35 childhood endodermal sinus tumor 11.3
36 central nervous system endodermal sinus tumor 11.3
37 childhood ovarian endodermal sinus tumor 11.3
38 pigmented villonodular synovitis 11.2
39 adult endodermal sinus tumor 11.2
40 ovarian endodermal sinus tumor 11.2
41 mediastinal endodermal sinus tumors 11.2
42 germ cells tumors 11.2
43 testis seminoma 11.1
44 mixed germ cell tumor 11.0 AFP KIT
45 indolent systemic mastocytosis 11.0 KIT KITLG
46 hepatic angiomyolipoma 11.0 AFP KIT
47 cutaneous mastocytosis 11.0 KIT KITLG
48 aggressive systemic mastocytosis 10.9 KIT KITLG
49 endometrial small cell carcinoma 10.9 AFP KIT
50 rete testis adenocarcinoma 10.9 AFP KIT

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor:



Diseases related to Testicular Germ Cell Tumor

Symptoms & Phenotypes for Testicular Germ Cell Tumor

Symptoms via clinical synopsis from OMIM:

57
GenitourinaryInternal GenitaliaMale:
painless testicular mass

Laboratory Abnormalities:
isochromosome 12p (i(12p))
elevated hcg (choriocarcinoma)
elevated afp (endodermal sinus tumor)
elevated hcg or afp or both (embryonal carcinoma)
azoospermia/oligospermia (present at diagnosis)

Neoplasia:
male germ cell tumors (gct), 2 subtypes -
seminoma
nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor)


Clinical features from OMIM:

273300

Human phenotypes related to Testicular Germ Cell Tumor:

32
# Description HPO Frequency HPO Source Accession
1 cryptorchidism 32 HP:0000028
2 gonadal dysgenesis 32 HP:0000133
3 abnormality of metabolism/homeostasis 32 HP:0001939
4 teratoma 32 HP:0009792

GenomeRNAi Phenotypes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 8.92 BRAF FGFR3 STK10 STK11

MGI Mouse Phenotypes related to Testicular Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 AFP BRAF FGFR3 KIT KITLG STK11

Drugs & Therapeutics for Testicular Germ Cell Tumor

Drugs for Testicular Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 240)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Vinblastine Approved Phase 3 865-21-4 13342 241903
7
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
8
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
9
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 51-75-2 4033
10
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
11
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
12
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
13
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
14
Ofloxacin Approved Phase 3 82419-36-1 4583
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
16
Captopril Approved Phase 3 62571-86-2 44093
17
Palivizumab Approved, Investigational Phase 3 188039-54-5
18
Ribavirin Approved Phase 3 36791-04-5 37542
19
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
20
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
21
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 22916-47-8 4189
22
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
23
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
24
Acyclovir Approved Phase 3 59277-89-3 2022
25
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
26 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
27
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
28
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
29
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
30
Polyestradiol phosphate Approved Phase 3 28014-46-2
31
Cyproheptadine Approved Phase 3 129-03-3 2913
32
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
33
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
34
Mycophenolic acid Approved Phase 3 24280-93-1 446541
35 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
36 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
37 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
39 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
40 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
41 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
42 Immunosuppressive Agents Phase 3,Phase 1,Phase 2,Not Applicable
43
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
44 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
45 Antiemetics Phase 3,Phase 2,Not Applicable
46 Autonomic Agents Phase 3,Phase 2,Not Applicable
47 Gastrointestinal Agents Phase 3,Phase 2,Not Applicable
48 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
49 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
50 Serotonin Agents Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 157)
# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
2 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
3 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
5 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
6 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
7 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
8 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
9 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
12 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
13 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
14 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
15 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
16 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
17 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
18 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
19 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
20 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
21 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
22 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
23 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
24 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
25 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
26 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
27 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
28 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
29 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
30 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
31 Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
32 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
33 Arsenic Trioxide in Treating Men With Germ Cell Cancer Completed NCT00036842 Phase 2 arsenic trioxide
34 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
35 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
36 Temozolomide in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to Cisplatin Completed NCT00006043 Phase 2 temozolomide
37 Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
38 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
39 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
40 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
41 Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory Cancer Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
42 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
43 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
44 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
45 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
46 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
47 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
48 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
49 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
50 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate

Search NIH Clinical Center for Testicular Germ Cell Tumor

Genetic Tests for Testicular Germ Cell Tumor

Genetic tests related to Testicular Germ Cell Tumor:

# Genetic test Affiliating Genes
1 Germ Cell Tumor, Nonseminomatous 29

Anatomical Context for Testicular Germ Cell Tumor

MalaCards organs/tissues related to Testicular Germ Cell Tumor:

41
Testis, Bone, Bone Marrow, Lymph Node, Brain, Small Intestine, Kidney

Publications for Testicular Germ Cell Tumor

Articles related to Testicular Germ Cell Tumor:

(show top 50) (show all 463)
# Title Authors Year
1
Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis. ( 29529997 )
2018
2
Re: MicroRNA miR-371a-3p-A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 29677902 )
2018
3
Prime evidence for testicular germ cell tumor initiation. ( 29545287 )
2018
4
Long-Term Cognitive Functioning in Testicular Germ-Cell Tumor Survivors. ( 29352051 )
2018
5
Risk stratification for febrile neutropenia in patients with testicular germ cell tumors. ( 29349917 )
2018
6
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. ( 29579225 )
2018
7
Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy. ( 29423028 )
2018
8
Characteristics, treatment decisions and outcomes of prepubertal testicular germ cell tumor: A descriptive analysis from a large Chinese center. ( 29705139 )
2018
9
Cutaneous Presentation of a Testicular Germ Cell Tumor With Seminomatous Differentiation. ( 28452794 )
2017
10
Editorial Comment: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28783265 )
2017
11
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. ( 28604732 )
2017
12
Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome. ( 28719895 )
2017
13
miRa89223a893p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. ( 28000896 )
2017
14
Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28266817 )
2017
15
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. ( 28604728 )
2017
16
Mosaic chromosome Y loss and testicular germ cell tumor risk. ( 28275244 )
2017
17
Future of testicular germ cell tumor incidence in the United States: Forecast through 2026. ( 28241106 )
2017
18
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. ( 29040905 )
2017
19
Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. ( 28471449 )
2017
20
Low hypoxia inducible factor-1I+ (HIF-1I+) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity? ( 28947870 )
2017
21
Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study. ( 28871003 )
2017
22
Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 29130004 )
2017
23
Reporting and Staging of Testicular Germ Cell Tumors: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations. ( 28368923 )
2017
24
K-RAS and N-RAS mutations in testicular germ cell tumors. ( 28426398 )
2017
25
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 28881587 )
2017
26
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation. ( 27017904 )
2016
27
Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor? ( 27255355 )
2016
28
Hotspot TERT promoter mutations are rare events in testicular germ cell tumors. ( 26526580 )
2016
29
Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors. ( 27803193 )
2016
30
Familial testicular germ cell tumor with bilateral disease. ( 27072274 )
2016
31
Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway. ( 27158395 )
2016
32
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 27517619 )
2016
33
Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor. ( 27242529 )
2016
34
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
35
More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. ( 27796764 )
2016
36
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. ( 27474852 )
2016
37
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. ( 26917601 )
2016
38
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016
39
Long-term Relative Survival after Diagnosis of Testicular Germ Cell Tumor. ( 26908435 )
2016
40
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. ( 27698832 )
2016
41
MAD2I^, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors. ( 27315568 )
2016
42
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. ( 26654129 )
2016
43
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
44
A rare cause in etiology of left atrial mass: metastatic testicular germ cell tumor. ( 27212979 )
2016
45
Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. ( 27085458 )
2016
46
Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy. ( 26956871 )
2016
47
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. ( 27754579 )
2016
48
Testicular germ cell tumor genomics. ( 27584029 )
2016
49
Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 27957372 )
2016
50
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. ( 27599467 )
2016

Variations for Testicular Germ Cell Tumor

UniProtKB/Swiss-Prot genetic disease variations for Testicular Germ Cell Tumor:

75
# Symbol AA change Variation ID SNP ID
1 FGFR3 p.Lys650Glu VAR_004160 rs78311289
2 STK10 p.Lys277Glu VAR_023827 rs757545210
3 STK11 p.Gly163Asp VAR_033140 rs137853078

ClinVar genetic disease variations for Testicular Germ Cell Tumor:

6
(show all 19)
# Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.499_500insT (p.Ser167Phefs) insertion Pathogenic rs387906350 GRCh37 Chromosome 1, 85733513: 85733513
2 BCL10 NM_003921.4(BCL10): c.499_500insT (p.Ser167Phefs) insertion Pathogenic rs387906350 GRCh38 Chromosome 1, 85267830: 85267830
3 BCL10 NM_003921.4(BCL10): c.172C> G (p.Arg58Gly) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
4 BCL10 NM_003921.4(BCL10): c.172C> G (p.Arg58Gly) single nucleotide variant Pathogenic rs121918314 GRCh38 Chromosome 1, 85270792: 85270792
5 BCL10 NM_003921.4(BCL10): c.172C> T (p.Arg58Ter) single nucleotide variant Pathogenic rs121918314 GRCh37 Chromosome 1, 85736475: 85736475
6 BCL10 NM_003921.4(BCL10): c.172C> T (p.Arg58Ter) single nucleotide variant Pathogenic rs121918314 GRCh38 Chromosome 1, 85270792: 85270792
7 STK11 NM_000455.4(STK11): c.488G> A (p.Gly163Asp) single nucleotide variant Pathogenic rs137853078 GRCh37 Chromosome 19, 1220395: 1220395
8 STK11 NM_000455.4(STK11): c.488G> A (p.Gly163Asp) single nucleotide variant Pathogenic rs137853078 GRCh38 Chromosome 19, 1220396: 1220396
9 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
10 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Likely pathogenic rs28933406 GRCh38 Chromosome 11, 533875: 533875
11 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic rs121913506 GRCh37 Chromosome 4, 55599320: 55599320
12 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic rs121913506 GRCh38 Chromosome 4, 54733154: 54733154
13 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 GRCh37 Chromosome 7, 140453136: 140453136
14 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 GRCh38 Chromosome 7, 140753336: 140753336
15 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 NCBI36 Chromosome 7, 140099605: 140099605
16 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889
17 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic rs78311289 GRCh38 Chromosome 4, 1806162: 1806162
18 BCL10 NM_003921.4(BCL10): c.488C> T (p.Thr163Met) single nucleotide variant Pathogenic rs370432633 GRCh37 Chromosome 1, 85733524: 85733524
19 BCL10 NM_003921.4(BCL10): c.488C> T (p.Thr163Met) single nucleotide variant Pathogenic rs370432633 GRCh38 Chromosome 1, 85267841: 85267841

Copy number variations for Testicular Germ Cell Tumor from CNVD:

7 (show all 12)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19332 1 149600000 247249719 Gain Testicular germ cell tumor
2 42821 10 40300000 82000000 Loss Testicular germ cell tumor
3 61421 12 1 132349534 Gain Testicular germ cell tumor
4 89303 15 17000000 76100000 Loss Testicular germ cell tumor
5 121721 18 46400000 76117153 Loss Testicular germ cell tumor
6 146937 2 56300000 230700000 Loss Testicular germ cell tumor
7 180589 4 107900000 191273063 Loss Testicular germ cell tumor
8 206877 6 149100000 170899992 Loss Testicular germ cell tumor
9 226157 7 55086724 55275030 Amplification EGFR Testicular germ cell tumor
10 245111 9 101600000 129300000 Loss Testicular germ cell tumor
11 261703 X 24900000 29400000 Gain Testicular germ cell tumor
12 262543 X 37500000 146900000 Gain Testicular germ cell tumor

Expression for Testicular Germ Cell Tumor

Search GEO for disease gene expression data for Testicular Germ Cell Tumor.

Pathways for Testicular Germ Cell Tumor

Pathways related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.83 FGFR3 MIR133B MIR145 MIR200C MIR373
2 10.62 MIR145 MIR371A MIR372 MIR373
3 10.36 KIT KITLG

GO Terms for Testicular Germ Cell Tumor

Biological processes related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.88 BRAF FGFR3 KIT STK10 STK11
2 negative regulation of signal transduction GO:0009968 9.67 BRAF FGFR3 KIT
3 MAPK cascade GO:0000165 9.67 BRAF FGFR3 KIT KITLG
4 male gonad development GO:0008584 9.63 DMRT1 KIT KITLG
5 phosphatidylinositol phosphorylation GO:0046854 9.61 FGFR3 KIT KITLG
6 embryonic hemopoiesis GO:0035162 9.4 KIT KITLG
7 germ cell migration GO:0008354 9.32 DMRT1 KIT
8 ectopic germ cell programmed cell death GO:0035234 9.26 KIT KITLG
9 protein autophosphorylation GO:0046777 9.26 FGFR3 KIT STK10 STK11
10 myeloid progenitor cell differentiation GO:0002318 9.16 BRAF KIT
11 gene silencing by miRNA GO:0035195 9.02 MIR133B MIR140 MIR145 MIR200C MIR372

Molecular functions related to Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.72 BRAF FGFR3 KIT STK10 STK11
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGFR3 KIT KITLG
3 MAP kinase kinase kinase activity GO:0004709 9.43 BRAF FGFR3 KIT
4 mitogen-activated protein kinase kinase binding GO:0031434 9.33 BRAF FGFR3 KIT
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 FGFR3 KIT KITLG
6 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR133B MIR140 MIR145 MIR200C MIR372

Sources for Testicular Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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