MCID: TST046
MIFTS: 23

Testicular Germ Cell Tumor 1

Categories: Reproductive diseases, Genetic diseases, Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Testicular Germ Cell Tumor 1

MalaCards integrated aliases for Testicular Germ Cell Tumor 1:

Name: Testicular Germ Cell Tumor 1 57 13 73
Testicular Germ Cell Tumor 57 73
Tgct1 57

Characteristics:

HPO:

32
testicular germ cell tumor 1:
Inheritance x-linked inheritance


Classifications:



External Ids:

OMIM 57 300228
MedGen 42 C1846164
SNOMED-CT via HPO 69 263934009
UMLS 73 C1846164

Summaries for Testicular Germ Cell Tumor 1

MalaCards based summary : Testicular Germ Cell Tumor 1, also known as testicular germ cell tumor, is related to testicular germ cell tumor. An important gene associated with Testicular Germ Cell Tumor 1 is TGCT1 (Testicular Germ Cell Tumor Susceptibility 1). Affiliated tissues include testis, lymph node and brain, and related phenotype is germ cell neoplasia.

Description from OMIM: 300228

Related Diseases for Testicular Germ Cell Tumor 1

Diseases in the Testicular Germ Cell Tumor family:

Testicular Germ Cell Tumor 1

Diseases related to Testicular Germ Cell Tumor 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 11.1

Symptoms & Phenotypes for Testicular Germ Cell Tumor 1

Clinical features from OMIM:

300228

Human phenotypes related to Testicular Germ Cell Tumor 1:

32
# Description HPO Frequency HPO Source Accession
1 germ cell neoplasia 32 HP:0100728

Drugs & Therapeutics for Testicular Germ Cell Tumor 1

Search Clinical Trials , NIH Clinical Center for Testicular Germ Cell Tumor 1

Genetic Tests for Testicular Germ Cell Tumor 1

Anatomical Context for Testicular Germ Cell Tumor 1

MalaCards organs/tissues related to Testicular Germ Cell Tumor 1:

41
Testis, Lymph Node, Brain, Testes, Lung, Kidney, Neutrophil

Publications for Testicular Germ Cell Tumor 1

Articles related to Testicular Germ Cell Tumor 1:

(show top 50) (show all 463)
# Title Authors Year
1
Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis. ( 29529997 )
2018
2
Re: MicroRNA miR-371a-3p-A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 29677902 )
2018
3
Prime evidence for testicular germ cell tumor initiation. ( 29545287 )
2018
4
Long-Term Cognitive Functioning in Testicular Germ-Cell Tumor Survivors. ( 29352051 )
2018
5
Risk stratification for febrile neutropenia in patients with testicular germ cell tumors. ( 29349917 )
2018
6
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. ( 29579225 )
2018
7
Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy. ( 29423028 )
2018
8
Characteristics, treatment decisions and outcomes of prepubertal testicular germ cell tumor: A descriptive analysis from a large Chinese center. ( 29705139 )
2018
9
Cutaneous Presentation of a Testicular Germ Cell Tumor With Seminomatous Differentiation. ( 28452794 )
2017
10
Editorial Comment: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28783265 )
2017
11
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. ( 28604732 )
2017
12
Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome. ( 28719895 )
2017
13
miRa89223a893p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. ( 28000896 )
2017
14
Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28266817 )
2017
15
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. ( 28604728 )
2017
16
Mosaic chromosome Y loss and testicular germ cell tumor risk. ( 28275244 )
2017
17
Future of testicular germ cell tumor incidence in the United States: Forecast through 2026. ( 28241106 )
2017
18
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. ( 29040905 )
2017
19
Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. ( 28471449 )
2017
20
Low hypoxia inducible factor-1I+ (HIF-1I+) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity? ( 28947870 )
2017
21
Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study. ( 28871003 )
2017
22
Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 29130004 )
2017
23
Reporting and Staging of Testicular Germ Cell Tumors: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations. ( 28368923 )
2017
24
K-RAS and N-RAS mutations in testicular germ cell tumors. ( 28426398 )
2017
25
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 28881587 )
2017
26
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation. ( 27017904 )
2016
27
Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor? ( 27255355 )
2016
28
Hotspot TERT promoter mutations are rare events in testicular germ cell tumors. ( 26526580 )
2016
29
Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors. ( 27803193 )
2016
30
Familial testicular germ cell tumor with bilateral disease. ( 27072274 )
2016
31
Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway. ( 27158395 )
2016
32
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 27517619 )
2016
33
Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor. ( 27242529 )
2016
34
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
35
More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. ( 27796764 )
2016
36
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. ( 27474852 )
2016
37
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. ( 26917601 )
2016
38
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016
39
Long-term Relative Survival after Diagnosis of Testicular Germ Cell Tumor. ( 26908435 )
2016
40
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. ( 27698832 )
2016
41
MAD2I^, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors. ( 27315568 )
2016
42
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. ( 26654129 )
2016
43
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
44
A rare cause in etiology of left atrial mass: metastatic testicular germ cell tumor. ( 27212979 )
2016
45
Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors. ( 27085458 )
2016
46
Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy. ( 26956871 )
2016
47
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. ( 27754579 )
2016
48
Testicular germ cell tumor genomics. ( 27584029 )
2016
49
Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 27957372 )
2016
50
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. ( 27599467 )
2016

Variations for Testicular Germ Cell Tumor 1

Expression for Testicular Germ Cell Tumor 1

Search GEO for disease gene expression data for Testicular Germ Cell Tumor 1.

Pathways for Testicular Germ Cell Tumor 1

GO Terms for Testicular Germ Cell Tumor 1

Sources for Testicular Germ Cell Tumor 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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