TGCT1
MCID: TST046
MIFTS: 36

Testicular Germ Cell Tumor 1 (TGCT1)

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Tumor 1

MalaCards integrated aliases for Testicular Germ Cell Tumor 1:

Name: Testicular Germ Cell Tumor 1 57 13 73
Testicular Germ Cell Tumor 57 73
Tgct1 57

Characteristics:

HPO:

32
testicular germ cell tumor 1:
Inheritance x-linked inheritance


Classifications:



External Ids:

OMIM 57 300228
MedGen 42 C1846164
SNOMED-CT via HPO 69 263934009

Summaries for Testicular Germ Cell Tumor 1

MalaCards based summary : Testicular Germ Cell Tumor 1, also known as testicular germ cell tumor, is related to testicular germ cell tumor and pediatric testicular germ cell tumor. An important gene associated with Testicular Germ Cell Tumor 1 is TGCT1 (Testicular Germ Cell Tumor Susceptibility 1). Affiliated tissues include bone, bone marrow and brain, and related phenotype is germ cell neoplasia.

Description from OMIM: 300228

Related Diseases for Testicular Germ Cell Tumor 1

Diseases in the Testicular Germ Cell Tumor family:

Testicular Germ Cell Tumor 1

Diseases related to Testicular Germ Cell Tumor 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 12.8
2 pediatric testicular germ cell tumor 12.5
3 testicular germ cell tumor non-seminomatous 12.3
4 testicular germ cell cancer 11.8
5 pigmented villonodular synovitis 11.3
6 testicular seminoma 11.3
7 germ cells tumors 11.1
8 perrault syndrome 1 11.1
9 seminoma 10.5
10 testicular microlithiasis 10.4
11 embryonal carcinoma 10.4
12 teratoma 10.3
13 rhabdomyosarcoma 10.2
14 choriocarcinoma 10.2
15 testicular cancer 10.2
16 down syndrome 10.1
17 wilms tumor 1 10.1
18 wilms tumor 6 10.1
19 angiosarcoma 10.1
20 azoospermia 10.1
21 endodermal sinus tumor 10.1
22 trophoblastic neoplasm 10.1
23 mature teratoma 10.1
24 hydrocele 10.1
25 leukemia, acute monocytic 9.9
26 prostate cancer 9.9
27 retinoblastoma 9.9
28 small cell cancer of the lung 9.9
29 lung cancer 9.9
30 chondrosarcoma 9.9
31 cryptorchidism, unilateral or bilateral 9.9
32 androgen insensitivity syndrome 9.9
33 anxiety 9.9
34 alpha-fetoprotein, hereditary persistence of 9.9
35 alopecia 9.9
36 leukemia 9.9
37 neutropenia 9.9
38 androgenic alopecia 9.9
39 thrombosis 9.9
40 polycystic kidney disease 9.9
41 sarcoma 9.9
42 gynecomastia 9.9
43 splenic infarction 9.9
44 cystic teratoma 9.9
45 adenocarcinoma 9.9
46 germ cell cancer 9.9
47 placental site trophoblastic tumor 9.9
48 gastric adenocarcinoma 9.9
49 infertility 9.9
50 heart sarcoma 9.9

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor 1:



Diseases related to Testicular Germ Cell Tumor 1

Symptoms & Phenotypes for Testicular Germ Cell Tumor 1

Clinical features from OMIM:

300228

Human phenotypes related to Testicular Germ Cell Tumor 1:

32
# Description HPO Frequency HPO Source Accession
1 germ cell neoplasia 32 HP:0100728

Drugs & Therapeutics for Testicular Germ Cell Tumor 1

Search Clinical Trials , NIH Clinical Center for Testicular Germ Cell Tumor 1

Genetic Tests for Testicular Germ Cell Tumor 1

Anatomical Context for Testicular Germ Cell Tumor 1

MalaCards organs/tissues related to Testicular Germ Cell Tumor 1:

41
Bone, Bone Marrow, Brain, Lymph Node, Testis, Lung, Kidney

Publications for Testicular Germ Cell Tumor 1

Articles related to Testicular Germ Cell Tumor 1:

(show top 50) (show all 203)
# Title Authors Year
1
Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis. ( 29529997 )
2018
2
Prime evidence for testicular germ cell tumor initiation. ( 29545287 )
2018
3
Long-Term Cognitive Functioning in Testicular Germ-Cell Tumor Survivors. ( 29352051 )
2018
4
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. ( 29579225 )
2018
5
Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy. ( 29423028 )
2018
6
Characteristics, treatment decisions and outcomes of prepubertal testicular germ cell tumor: A descriptive analysis from a large Chinese center. ( 29705139 )
2018
7
CK7, inhibin, and p63 in testicular germ cell tumor: superior markers of Choriocarcinoma compared to β-hCG. ( 30359635 )
2018
8
Mature Cystic Teratoma of the Lung With a Somatic-Like Malignant Component in a Patient With Testicular Germ-Cell Tumor. ( 30041955 )
2018
9
Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma. ( 30266250 )
2018
10
Re: Identification of 19 New Risk Loci and Potential Regulatory Mechanisms Influencing Susceptibility to Testicular Germ Cell Tumor. ( 30227584 )
2018
11
A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth. ( 30237497 )
2018
12
MiR-371a-3p Serum Levels Are Increased in Recurrence of Testicular Germ Cell Tumor Patients. ( 30321995 )
2018
13
Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor. ( 30519350 )
2018
14
Cutaneous Presentation of a Testicular Germ Cell Tumor With Seminomatous Differentiation. ( 28452794 )
2017
15
Editorial Comment: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28783265 )
2017
16
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. ( 28604732 )
2017
17
Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy. ( 28266817 )
2017
18
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. ( 28604728 )
2017
19
Mosaic chromosome Y loss and testicular germ cell tumor risk. ( 28275244 )
2017
20
Future of testicular germ cell tumor incidence in the United States: Forecast through 2026. ( 28241106 )
2017
21
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. ( 29040905 )
2017
22
Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study. ( 28871003 )
2017
23
Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 29130004 )
2017
24
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 28881587 )
2017
25
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation. ( 27017904 )
2016
26
Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor? ( 27255355 )
2016
27
Familial testicular germ cell tumor with bilateral disease. ( 27072274 )
2016
28
Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway. ( 27158395 )
2016
29
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. ( 27517619 )
2016
30
Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor. ( 27242529 )
2016
31
A CASE OF ADVANCED NON-SEMINOMATOUS TESTICULAR GERM CELL TUMOR ACCOMPANIED PANIC DISORDER. ( 28132992 )
2016
32
More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases. ( 27796764 )
2016
33
Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. ( 27474852 )
2016
34
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. ( 26917601 )
2016
35
Long-term Relative Survival after Diagnosis of Testicular Germ Cell Tumor. ( 26908435 )
2016
36
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients. ( 27698832 )
2016
37
A rare cause in etiology of left atrial mass: metastatic testicular germ cell tumor. ( 27212979 )
2016
38
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. ( 27754579 )
2016
39
Testicular germ cell tumor genomics. ( 27584029 )
2016
40
Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review. ( 27957372 )
2016
41
Brain Metastases as Presenting Feature in 'Burned Out' Testicular Germ Cell Tumor. ( 27182465 )
2016
42
Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. ( 27999814 )
2016
43
Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor. ( 27863478 )
2016
44
Novel association of familial testicular germ cell tumor and autosomal dominant polycystic kidney disease with PKD1 mutation. ( 27577987 )
2016
45
Identifying functional cancer-specific miRNA-mRNA interactions in testicular germ cell tumor. ( 27235586 )
2016
46
Testicular germ cell tumor: Short and long-term side effects of treatment among survivors. ( 27588190 )
2016
47
Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. ( 25877299 )
2015
48
Oncological Outcomes in Japanese Men Undergoing Orchiectomy for Stage I Testicular Germ Cell Tumor. ( 26889123 )
2015
49
Disparities in Interpretation of Primary Testicular Germ Cell Tumor Pathology. ( 26185314 )
2015
50
Benign neck metastasis of a testicular germ cell tumor. ( 25594657 )
2015

Variations for Testicular Germ Cell Tumor 1

Expression for Testicular Germ Cell Tumor 1

Search GEO for disease gene expression data for Testicular Germ Cell Tumor 1.

Pathways for Testicular Germ Cell Tumor 1

GO Terms for Testicular Germ Cell Tumor 1

Sources for Testicular Germ Cell Tumor 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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