TGCT1
MCID: TST046
MIFTS: 27

Testicular Germ Cell Tumor 1 (TGCT1)

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Germ Cell Tumor 1

MalaCards integrated aliases for Testicular Germ Cell Tumor 1:

Name: Testicular Germ Cell Tumor 1 57 13 70
Testicular Germ Cell Tumor 57 70
Tgct1 57

Characteristics:

HPO:

31
testicular germ cell tumor 1:
Inheritance x-linked inheritance


Classifications:



External Ids:

OMIM® 57 300228
MedGen 41 C1846164
SNOMED-CT via HPO 68 263934009
UMLS 70 C1336708 C1846164

Summaries for Testicular Germ Cell Tumor 1

MalaCards based summary : Testicular Germ Cell Tumor 1, also known as testicular germ cell tumor, is related to testicular germ cell tumor and pediatric testicular germ cell tumor. An important gene associated with Testicular Germ Cell Tumor 1 is TGCT1 (Testicular Germ Cell Tumor Susceptibility 1). The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, kidney and lymph node, and related phenotype is germ cell neoplasia.

More information from OMIM: 300228

Related Diseases for Testicular Germ Cell Tumor 1

Diseases in the Testicular Germ Cell Tumor family:

Testicular Germ Cell Tumor 1

Diseases related to Testicular Germ Cell Tumor 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 11.9
2 pediatric testicular germ cell tumor 11.6
3 testicular germ cell cancer 11.5
4 testicular cancer 11.4
5 testicular germ cell tumor non-seminomatous 11.4
6 testicular seminoma 11.3
7 pigmented villonodular synovitis 11.3
8 germ cells tumors 11.2
9 seminoma 10.9
10 teratoma 10.8
11 embryonal carcinoma 10.8
12 nonseminomatous germ cell tumor 10.7
13 endodermal sinus tumor 10.6
14 testicular yolk sac tumor 10.6
15 choriocarcinoma 10.5
16 mixed germ cell tumor 10.5
17 germ cell cancer 10.5
18 cryptorchidism, unilateral or bilateral 10.4
19 mature teratoma 10.4
20 rhabdomyosarcoma 10.3
21 infertility 10.3
22 in situ carcinoma 10.3
23 sarcoidosis 1 10.3
24 testicular microlithiasis 10.3
25 inguinal hernia 10.3
26 male infertility 10.3
27 teratocarcinoma 10.3
28 argyria 10.3
29 retinoblastoma 10.2
30 wilms tumor 1 10.2
31 angiosarcoma 10.2
32 hypospadias 10.2
33 respiratory failure 10.2
34 infant gynecomastia 10.2
35 pancytopenia 10.2
36 gynecomastia 10.2
37 melanoma 10.2
38 trophoblastic neoplasm 10.2
39 severe combined immunodeficiency 10.2
40 pulmonary embolism 10.2
41 alopecia 10.2
42 bladder cancer 10.0
43 epidermoid cysts 10.0
44 factor viii deficiency 10.0
45 leukemia, acute monocytic 10.0
46 prostate cancer 10.0
47 down syndrome 10.0
48 uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis 10.0
49 chondrosarcoma 10.0
50 immune deficiency disease 10.0

Graphical network of the top 20 diseases related to Testicular Germ Cell Tumor 1:



Diseases related to Testicular Germ Cell Tumor 1

Symptoms & Phenotypes for Testicular Germ Cell Tumor 1

Human phenotypes related to Testicular Germ Cell Tumor 1:

31
# Description HPO Frequency HPO Source Accession
1 germ cell neoplasia 31 HP:0100728

Clinical features from OMIM®:

300228 (Updated 20-May-2021)

Drugs & Therapeutics for Testicular Germ Cell Tumor 1

Drugs for Testicular Germ Cell Tumor 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
4
Ifosfamide Approved Phase 2 3778-73-2 3690
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
7
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
8
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
9
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
10
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
11
Etoposide Approved Phase 2 33419-42-0 36462
12
Lenograstim Approved, Investigational Phase 2 135968-09-1
13
leucovorin Approved Phase 2 58-05-9 6006
14
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
15 Antimetabolites Phase 2
16
Isophosphamide mustard Phase 2 100427
17 Tubulin Modulators Phase 2
18 Albumin-Bound Paclitaxel Phase 2
19 Antimitotic Agents Phase 2
20 Alkylating Agents Phase 2
21 Anti-Infective Agents Phase 2
22
Liposomal doxorubicin Phase 2 31703
23 Antirheumatic Agents Phase 2
24 Micronutrients Phase 2
25 Antidotes Phase 2
26 Trace Elements Phase 2
27 Vitamin B9 Phase 2
28 Nutrients Phase 2
29 Immunosuppressive Agents Phase 2
30 Folic Acid Antagonists Phase 2
31 Vitamin B Complex Phase 2
32 Antibiotics, Antitubercular Phase 2
33 Folate Phase 2
34 Anti-Bacterial Agents Phase 2
35 Etoposide phosphate Phase 2
36 Protective Agents Phase 2
37 Vitamins Phase 2
38 Immunologic Factors Phase 2
39 Calcium, Dietary Phase 2
40 Dermatologic Agents Phase 2
41
Calcium Nutraceutical Phase 2 7440-70-2 271
42
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
43
Guadecitabine Investigational Phase 1 929901-49-5
44 Fluorodeoxyglucose F18
45 Radiopharmaceuticals

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
2 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
3 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
4 PROTOCOL FOR THE TREATMENT OF MALIGNANT NON-TESTICULAR GERM CELL TUMORS Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
5 Phase II Single-arm Trial to Evaluate Progression Free Survival With Primary Retroperitoneal Lymph-node Dissection (pRPLND) Only in Patients With Seminomatous Testicular Germ Cell Tumors With Clinical Stage IIA/B (PRIMETEST) Recruiting NCT02797626 Phase 2
6 Phase I Study of the Hypomethylating Drug SGI-110 Plus Cisplatin in Relapsed Refractory Germ Cell Tumors Completed NCT02429466 Phase 1 Guadecitabine (SGI-110)
7 Phase I Study to Determine the Safety of MEN-10755 (BMS-195615) in Patients With a Solid Tumor on a Short I.V. Infusion Given Once Every Week for 3 Consecutive Weeks, Followed by One Week's Rest Completed NCT00003982 Phase 1 sabarubicin
8 Assessment of the Utility of CT Follow Up in the Long Term Follow Up of Patients With Metastatic Non Seminomatous Germ Cell Tumour (NSGCT) Unknown status NCT00553371
9 A Study of the Natural History of Cisplatin-Induced Peripheral Neuropathy in Patients With Germ Cell Tumor Completed NCT02677727
10 A Multicentric Case-control Study to Assess the Association Between Environmental, Domestic and Occupational Exposures During Antenatal and Early Postnatal Periods and the Risk to Develop a Testicular Germ Cell Tumor During Adulthood Completed NCT02109926
11 Correlation of Histopathology, Immunohistochemistry and Quantitative Radiology With Outcome in Early Stage Nonseminomatous Germ Cell Tumor Completed NCT00003800
12 A Study Of 18 FDG PET In The Prediction Of Relapse In Patients With A Clinical Stage I Non-Seminomatous Germ Cell Tumor Completed NCT00045045
13 A Study of CT Scan Frequency in Patients With Stage I Testicular Teratoma Completed NCT00003420
14 Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Studies of Familial Testicular Germ Cell Tumors Completed NCT00342537
15 A Case-Control Study of Testicular Germ Cell Tumors Among U.S. Military Servicemen Completed NCT00341588
16 Exploratory Study of Molecular Characterization in Patients With Metastatic Germ Cell Tumours Refractory/Resistant to Platinum Treatment Recruiting NCT03980587
17 Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors Recruiting NCT02303015
18 Financial Toxicity and Quality of Life in Patients With Testicular Germ Cell Tumors Recruiting NCT04531709
19 Sentinel Lymph Node Procedure in Testicular Germ Cell Tumour Not yet recruiting NCT03448822

Search NIH Clinical Center for Testicular Germ Cell Tumor 1

Genetic Tests for Testicular Germ Cell Tumor 1

Anatomical Context for Testicular Germ Cell Tumor 1

MalaCards organs/tissues related to Testicular Germ Cell Tumor 1:

40
Testis, Kidney, Lymph Node, Uterus, Myeloid, Heart, Breast

Publications for Testicular Germ Cell Tumor 1

Articles related to Testicular Germ Cell Tumor 1:

# Title Authors PMID Year
1
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. 57
10655070 2000
2
Cancer incidence in men with Klinefelter syndrome. 57
7841064 1995
3
Mediastinal germ cell tumour associated with Klinefelter syndrome. A report of case and review of the literature. 57
1425792 1992
4
Establishment and characterization of a novel cell line, NCC-TGCT1-C1, derived from a patient with tenosynovial giant cell tumor. 61
32886306 2021
5
Identification of genomic locus responsible for experimentally induced testicular teratoma 1 (ett1) on mouse Chr 18. 61
24997020 2014
6
Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis. 61
19373475 2009
7
Intratubular germ cell neoplasia of unclassified type. 61
16786725 2006
8
Genetic predisposition to testicular germ-cell tumours. 61
15172357 2004
9
The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. 61
12629412 2003
10
Localisation of susceptibility genes for familial testicular germ cell tumour. 61
12752252 2003

Variations for Testicular Germ Cell Tumor 1

Expression for Testicular Germ Cell Tumor 1

Search GEO for disease gene expression data for Testicular Germ Cell Tumor 1.

Pathways for Testicular Germ Cell Tumor 1

GO Terms for Testicular Germ Cell Tumor 1

Sources for Testicular Germ Cell Tumor 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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