MCID: TST005
MIFTS: 22

Testicular Gonadoblastoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Gonadoblastoma

MalaCards integrated aliases for Testicular Gonadoblastoma:

Name: Testicular Gonadoblastoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3579
NCIt 50 C39911
UMLS 70 C1515283

Summaries for Testicular Gonadoblastoma

MalaCards based summary : Testicular Gonadoblastoma is related to gonadoblastoma and conventional fibrosarcoma. An important gene associated with Testicular Gonadoblastoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hippo signaling pathway and Apoptotic cleavage of cellular proteins. Affiliated tissues include thyroid, bone marrow and bone, and related phenotype is reproductive system.

Related Diseases for Testicular Gonadoblastoma

Diseases related to Testicular Gonadoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 gonadoblastoma 30.2 KIT AMH
2 conventional fibrosarcoma 10.1 KIT CTNNB1
3 chondroma 10.1 KIT CTNNB1
4 uterine body mixed cancer 10.0 KIT CTNNB1
5 mixed cell type cancer 10.0 KIT CTNNB1
6 connective tissue benign neoplasm 10.0 KIT CTNNB1
7 desmoid tumor 10.0 KIT CTNNB1
8 oropharynx cancer 10.0 KIT CTNNB1
9 myoma 10.0 KIT AMH
10 mullerian aplasia and hyperandrogenism 10.0 CTNNB1 AMH
11 mixed gonadal dysgenesis 10.0 KIT AMH
12 merkel cell carcinoma 10.0 KIT CTNNB1
13 uterine carcinosarcoma 10.0 KIT CTNNB1
14 uterine benign neoplasm 10.0 CTNNB1 AMH
15 reproductive organ benign neoplasm 10.0 CTNNB1 AMH
16 colorectal adenocarcinoma 10.0 KIT CTNNB1
17 testicular disease 10.0 KIT AMH
18 seminoma 10.0
19 oligospermia 10.0 KIT AMH
20 thyroid gland follicular carcinoma 9.9 KIT CTNNB1
21 thyroid gland anaplastic carcinoma 9.9 KIT CTNNB1
22 peripheral nervous system neoplasm 9.9 KIT CTNNB1
23 cell type benign neoplasm 9.9 KIT CTNNB1
24 fibroma 9.9 VIM CTNNB1
25 fibromatosis 9.9 VIM CTNNB1
26 liver fibroma 9.9 VIM KIT
27 senile angioma 9.9 VIM KIT
28 esophageal adenoid cystic carcinoma 9.9 VIM KIT
29 vaginal endometrial stromal sarcoma 9.9 VIM KIT
30 endometrial stromal sarcoma 9.9 VIM KIT
31 mast-cell sarcoma 9.9 VIM KIT
32 vagina sarcoma 9.9 VIM KIT
33 benign breast phyllodes tumor 9.9 VIM KIT
34 bladder leiomyoma 9.9 VIM KIT
35 leiomyoma 9.9 VIM KIT
36 melanoma, cutaneous malignant 1 9.9 KIT CTNNB1
37 cataract 30 9.9 VIM CTNNB1
38 acral lentiginous melanoma 9.9 VIM KIT
39 pleomorphic liposarcoma 9.9 VIM KIT
40 liposarcoma 9.9 VIM CTNNB1
41 adenosarcoma 9.9 VIM KIT
42 perineurioma 9.9 VIM KIT
43 perivascular epithelioid cell tumor 9.9 VIM KIT
44 endocervical carcinoma 9.9 VIM CTNNB1
45 nephroma 9.9 VIM KIT
46 hemangiopericytoma, malignant 9.9 VIM KIT
47 smooth muscle tumor 9.9 VIM KIT
48 fibrolamellar carcinoma 9.9 VIM CTNNB1
49 renal oncocytoma 9.9 VIM KIT
50 oncocytoma 9.9 VIM KIT

Graphical network of the top 20 diseases related to Testicular Gonadoblastoma:



Diseases related to Testicular Gonadoblastoma

Symptoms & Phenotypes for Testicular Gonadoblastoma

MGI Mouse Phenotypes related to Testicular Gonadoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 8.92 AMH CTNNB1 KIT VIM

Drugs & Therapeutics for Testicular Gonadoblastoma

Search Clinical Trials , NIH Clinical Center for Testicular Gonadoblastoma

Genetic Tests for Testicular Gonadoblastoma

Anatomical Context for Testicular Gonadoblastoma

MalaCards organs/tissues related to Testicular Gonadoblastoma:

40
Thyroid, Bone Marrow, Bone, Smooth Muscle, Liver, Breast

Publications for Testicular Gonadoblastoma

Articles related to Testicular Gonadoblastoma:

# Title Authors PMID Year
1
Testicular gonadoblastoma in two pet domestic rabbits (Oryctolagus cuniculus domesticus). 61
21908369 2011
2
Neonatal cystic testicular gonadoblastoma. Sonographic and pathologic findings. 61
1997687 1991

Variations for Testicular Gonadoblastoma

Expression for Testicular Gonadoblastoma

Search GEO for disease gene expression data for Testicular Gonadoblastoma.

Pathways for Testicular Gonadoblastoma

GO Terms for Testicular Gonadoblastoma

Biological processes related to Testicular Gonadoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.37 KIT CTNNB1
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.32 KIT CTNNB1
3 hemopoiesis GO:0030097 9.26 KIT CTNNB1
4 stem cell population maintenance GO:0019827 9.16 KIT CTNNB1
5 T cell differentiation GO:0030217 8.96 KIT CTNNB1
6 positive regulation of gene expression GO:0010628 8.92 VIM KIT CTNNB1 AMH

Sources for Testicular Gonadoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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