MCID: TST016
MIFTS: 22

Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Testicular Granulosa Cell Tumor:

Name: Testicular Granulosa Cell Tumor 12 15 73
Granulosa Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5331
NCIt 50 C6357
UMLS 73 C1336709

Summaries for Testicular Granulosa Cell Tumor

MalaCards based summary : Testicular Granulosa Cell Tumor, also known as granulosa cell tumor of testis, is related to juvenile type testicular granulosa cell tumor and adult type testicular granulosa cell tumor. An important gene associated with Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, and related phenotype is liver/biliary system.

Related Diseases for Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 juvenile type testicular granulosa cell tumor 26.4 AFP CD99 CEACAM5 CSH1 CSH2 DICER1
2 adult type testicular granulosa cell tumor 12.4
3 maligant granulosa cell tumor of the ovary 10.8 DICER1 FOXL2
4 corpus luteum cyst 10.8 AFP FOXL2
5 gynandroblastoma 10.7 DICER1 FOXL2
6 ovarian cyst 10.7 AFP FOXL2
7 ovarian small cell carcinoma 10.6 SMARCA4 WT1
8 tumor predisposition syndrome 10.6 DICER1 SMARCA4
9 kidney sarcoma 10.6 DICER1 WT1
10 adenomatoid tumor 10.6 AFP WT1
11 cystic nephroma 10.6 DICER1 WT1
12 nephrotic syndrome, type 1 10.5 AFP WT1
13 pineoblastoma 10.5 AFP DICER1
14 testicular trophoblastic tumor 10.5 CSH1 CSH2
15 kidney rhabdoid cancer 10.5 CD99 WT1
16 choriocarcinoma of ovary 10.5 CSH1 CSH2
17 mucinous cystadenofibroma 10.5 AFP CEACAM5
18 reproductive organ benign neoplasm 10.5 AFP DICER1
19 urachal adenocarcinoma 10.5 AFP CEACAM5
20 liver lymphoma 10.5 AFP CEACAM5
21 melanotic medulloblastoma 10.5 AFP CEACAM5
22 non-gestational choriocarcinoma 10.4 CSH1 CSH2
23 hematocele of tunica vaginalis testis 10.4 AFP CEACAM5
24 bile duct cystadenocarcinoma 10.4 AFP CEACAM5
25 liver sarcoma 10.4 AFP CEACAM5
26 rete testis adenocarcinoma 10.4 AFP CEACAM5
27 gestational trophoblastic neoplasm 10.4 CSH1 CSH2
28 gonadoblastoma 10.4 FOXL2 WT1
29 rete testis neoplasm 10.3 AFP CEACAM5
30 pancreatic cystadenocarcinoma 10.3 AFP CEACAM5
31 extragonadal seminoma 10.3 AFP CEACAM5
32 bone ewing's sarcoma 10.3 CD99 WT1
33 epidermolysis bullosa, junctional, herlitz type 10.3 AFP CEACAM5
34 sertoli-leydig cell tumor 10.3 AFP DICER1 WT1
35 breast adenomyoepithelioma 10.3 CD99 CEACAM5
36 dysgerminoma of ovary 10.3 AFP DICER1 WT1
37 chronic salpingitis 10.2 CSH1 CSH2
38 breast myoepithelial neoplasm 10.2 CD99 CEACAM5
39 ovarian mucinous neoplasm 10.2 CEACAM5 WT1
40 female reproductive system disease 10.2 CSH1 CSH2 FOXL2
41 choriocarcinoma of the testis 10.2 AFP CSH1 CSH2
42 rh isoimmunization 10.2 AFP CSH1 CSH2
43 germ cell and embryonal cancer 10.1 AFP CSH1 CSH2
44 uterine anomalies 10.1 AFP CSH1 CSH2
45 placenta disease 10.1 AFP CSH1 CSH2
46 bile duct adenocarcinoma 10.1 AFP CEACAM5
47 ovarian melanoma 10.1 MLANA SMARCA4
48 malignant biphasic mesothelioma 10.0 AFP CEACAM5 WT1
49 ovarian cancer 1 10.0 CEACAM5 WT1
50 epithelioid cell melanoma 10.0 MLANA WT1

Graphical network of the top 20 diseases related to Testicular Granulosa Cell Tumor:



Diseases related to Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Testicular Granulosa Cell Tumor

MGI Mouse Phenotypes related to Testicular Granulosa Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.02 AFP DICER1 IGFBP2 SMARCA4 WT1

Drugs & Therapeutics for Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Granulosa Cell Tumor

Genetic Tests for Testicular Granulosa Cell Tumor

Anatomical Context for Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Testicular Granulosa Cell Tumor:

41
Testis

Publications for Testicular Granulosa Cell Tumor

Articles related to Testicular Granulosa Cell Tumor:

# Title Authors Year
1
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. ( 21204721 )
2011
2
Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. ( 19777766 )
2009
3
Testicular granulosa cell tumor, adult type. ( 18723972 )
2008
4
Testicular granulosa cell tumor of adult type: a new case and a review of the literature. ( 17628299 )
2007
5
Adult-type testicular granulosa cell tumor: case report and review of the literature. ( 17095056 )
2006
6
Testicular granulosa cell tumor of the adult type. ( 1536615 )
1992

Variations for Testicular Granulosa Cell Tumor

Expression for Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Testicular Granulosa Cell Tumor.

Pathways for Testicular Granulosa Cell Tumor

Pathways related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 AFP SMARCA4 WT1

GO Terms for Testicular Granulosa Cell Tumor

Biological processes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic DNA fragmentation GO:0006309 8.62 DICER1 FOXL2

Sources for Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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