MCID: TST016
MIFTS: 28

Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Testicular Granulosa Cell Tumor:

Name: Testicular Granulosa Cell Tumor 12 15 73
Granulosa Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5331
NCIt 50 C6357
UMLS 73 C1336709

Summaries for Testicular Granulosa Cell Tumor

MalaCards based summary : Testicular Granulosa Cell Tumor, also known as granulosa cell tumor of testis, is related to juvenile type testicular granulosa cell tumor and adult type testicular granulosa cell tumor. An important gene associated with Testicular Granulosa Cell Tumor is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Direct p53 effectors and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, kidney and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Testicular Granulosa Cell Tumor

Graphical network of the top 20 diseases related to Testicular Granulosa Cell Tumor:



Diseases related to Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Testicular Granulosa Cell Tumor

GenomeRNAi Phenotypes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.5 AFP FOXL2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.5 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.5 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.5 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.5 AFP FOXL2
6 shRNA abundance <= 50% GR00343-S 9.02 DICER1 FOXL2 PTH1R SMARCA4 WT1

MGI Mouse Phenotypes related to Testicular Granulosa Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.88 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1
2 homeostasis/metabolism MP:0005376 9.85 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1
3 embryo MP:0005380 9.73 DICER1 PTH1R SMARCA4 WT1
4 mortality/aging MP:0010768 9.73 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1
5 liver/biliary system MP:0005370 9.72 AFP DICER1 PTH1R SMARCA4 WT1
6 neoplasm MP:0002006 9.55 AFP DICER1 PTH1R SMARCA4 WT1
7 respiratory system MP:0005388 9.26 DICER1 PTH1R SMARCA4 WT1
8 vision/eye MP:0005391 8.92 DICER1 FOXL2 PTH1R SMARCA4

Drugs & Therapeutics for Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Granulosa Cell Tumor

Genetic Tests for Testicular Granulosa Cell Tumor

Anatomical Context for Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Testicular Granulosa Cell Tumor:

41
Testis, Kidney, Ovary

Publications for Testicular Granulosa Cell Tumor

Articles related to Testicular Granulosa Cell Tumor:

# Title Authors Year
1
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. ( 21204721 )
2011
2
Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. ( 19777766 )
2009
3
Testicular granulosa cell tumor, adult type. ( 18723972 )
2008
4
Testicular granulosa cell tumor of adult type: a new case and a review of the literature. ( 17628299 )
2007
5
Adult-type testicular granulosa cell tumor: case report and review of the literature. ( 17095056 )
2006
6
Testicular granulosa cell tumor of the adult type. ( 1536615 )
1992

Variations for Testicular Granulosa Cell Tumor

Expression for Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Testicular Granulosa Cell Tumor.

Pathways for Testicular Granulosa Cell Tumor

Pathways related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.28 AFP SMARCA4
2 10.92 AFP SMARCA4 WT1
3 10.87 AFP SMARCA4

GO Terms for Testicular Granulosa Cell Tumor

Biological processes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 FOXL2 SMARCA4 WT1
2 negative regulation of transcription, DNA-templated GO:0045892 9.43 FOXL2 SMARCA4 WT1
3 negative regulation of cell growth GO:0030308 9.37 SMARCA4 WT1
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.26 DICER1 FOXL2 SMARCA4 WT1
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.16 SMARCA4 WT1
6 apoptotic DNA fragmentation GO:0006309 8.62 DICER1 FOXL2

Sources for Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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