MCID: TST016
MIFTS: 29

Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Testicular Granulosa Cell Tumor:

Name: Testicular Granulosa Cell Tumor 12 15 17 74
Granulosa Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5331
NCIt 51 C6357
UMLS 74 C1336709

Summaries for Testicular Granulosa Cell Tumor

MalaCards based summary : Testicular Granulosa Cell Tumor, also known as granulosa cell tumor of testis, is related to juvenile type testicular granulosa cell tumor and adult type testicular granulosa cell tumor. An important gene associated with Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Glucocorticoid receptor regulatory network. Affiliated tissues include testis, kidney and ovary, and related phenotypes are Decreased ionizing radiation sensitivity and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 juvenile type testicular granulosa cell tumor 32.4 AFP DICER1 FOXL2 SMARCA4 WT1
2 adult type testicular granulosa cell tumor 12.6
3 maligant granulosa cell tumor of the ovary 10.1 DICER1 FOXL2
4 gynandroblastoma 10.1 DICER1 FOXL2
5 ovarian small cell carcinoma 10.1 SMARCA4 WT1
6 rhabdoid cancer 10.1 SMARCA4 WT1
7 kidney sarcoma 10.1 DICER1 WT1
8 tumor predisposition syndrome 10.0 DICER1 SMARCA4
9 cystic nephroma 10.0 DICER1 WT1
10 gonadoblastoma 10.0 FOXL2 WT1
11 kidney benign neoplasm 10.0 DICER1 WT1
12 46,xy partial gonadal dysgenesis 10.0 NR5A1 WT1
13 corpus luteum cyst 9.9 AFP FOXL2
14 denys-drash syndrome 9.9 NR5A1 WT1
15 ovarian cyst 9.9 AFP FOXL2
16 reproductive organ benign neoplasm 9.9 AFP DICER1
17 persistent mullerian duct syndrome 9.9 NR5A1 WT1
18 dysgerminoma 9.9 AFP WT1
19 46 xy gonadal dysgenesis 9.9 NR5A1 WT1
20 adenomatoid tumor 9.9 AFP WT1
21 frasier syndrome 9.9 NR5A1 WT1
22 nephrotic syndrome, type 1 9.8 AFP WT1
23 leydig cell tumor 9.8 AFP NR5A1
24 pineoblastoma 9.8 AFP DICER1
25 pseudohermaphroditism 9.8 NR5A1 WT1
26 cryptorchidism, unilateral or bilateral 9.8 NR5A1 WT1
27 testicular disease 9.8 AFP DICER1
28 gonadal dysgenesis 9.8 FOXL2 NR5A1 WT1
29 premature ovarian failure 1 9.8 FOXL2 NR5A1 WT1
30 cloacal exstrophy 9.8 AFP NR5A1
31 hypospadias 9.7 NR5A1 WT1
32 ovarian disease 9.7 FOXL2 NR5A1
33 sertoli-leydig cell tumor 9.6 AFP DICER1 WT1
34 dysgerminoma of ovary 9.6 AFP DICER1 WT1
35 gonadal disease 9.6 AFP FOXL2 NR5A1
36 male reproductive organ benign neoplasm 9.0 AFP DICER1 FOXL2 NR5A1 WT1
37 sex cord-gonadal stromal tumor 9.0 AFP DICER1 FOXL2 NR5A1 WT1

Graphical network of the top 20 diseases related to Testicular Granulosa Cell Tumor:



Diseases related to Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Testicular Granulosa Cell Tumor

GenomeRNAi Phenotypes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased ionizing radiation sensitivity GR00232-A-1 9.46 AFP DICER1 NR5A1 SMARCA4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.43 AFP FOXL2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.43 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.43 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.43 AFP FOXL2
6 shRNA abundance <= 50% GR00343-S 9.02 DICER1 FOXL2 NR5A1 SMARCA4 WT1

MGI Mouse Phenotypes related to Testicular Granulosa Cell Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.88 AFP DICER1 FOXL2 NR5A1 SMARCA4 WT1
2 homeostasis/metabolism MP:0005376 9.85 AFP DICER1 FOXL2 NR5A1 SMARCA4 WT1
3 embryo MP:0005380 9.73 DICER1 NR5A1 SMARCA4 WT1
4 mortality/aging MP:0010768 9.73 AFP DICER1 FOXL2 NR5A1 SMARCA4 WT1
5 liver/biliary system MP:0005370 9.62 AFP DICER1 SMARCA4 WT1
6 neoplasm MP:0002006 9.46 AFP DICER1 SMARCA4 WT1
7 normal MP:0002873 9.35 DICER1 FOXL2 NR5A1 SMARCA4 WT1
8 reproductive system MP:0005389 9.02 AFP DICER1 FOXL2 NR5A1 WT1

Drugs & Therapeutics for Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Granulosa Cell Tumor

Genetic Tests for Testicular Granulosa Cell Tumor

Anatomical Context for Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Testicular Granulosa Cell Tumor:

42
Testis, Kidney, Ovary

Publications for Testicular Granulosa Cell Tumor

Articles related to Testicular Granulosa Cell Tumor:

# Title Authors Year
1
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. ( 21204721 )
2011
2
Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. ( 19777766 )
2009
3
Testicular granulosa cell tumor, adult type. ( 18723972 )
2008
4
Testicular granulosa cell tumor of adult type: a new case and a review of the literature. ( 17628299 )
2007
5
Adult-type testicular granulosa cell tumor: case report and review of the literature. ( 17095056 )
2006
6
Testicular granulosa cell tumor of the adult type. ( 1536615 )
1992

Variations for Testicular Granulosa Cell Tumor

Expression for Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Testicular Granulosa Cell Tumor.

Pathways for Testicular Granulosa Cell Tumor

Pathways related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 AFP SMARCA4 WT1
2 10.87 AFP SMARCA4

GO Terms for Testicular Granulosa Cell Tumor

Biological processes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.83 FOXL2 NR5A1 SMARCA4 WT1
2 regulation of transcription by RNA polymerase II GO:0006357 9.81 FOXL2 NR5A1 SMARCA4 WT1
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 FOXL2 NR5A1 SMARCA4 WT1
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.76 DICER1 FOXL2 SMARCA4 WT1
5 negative regulation of transcription, DNA-templated GO:0045892 9.71 FOXL2 SMARCA4 WT1
6 negative regulation of cell growth GO:0030308 9.57 SMARCA4 WT1
7 positive regulation of transcription, DNA-templated GO:0045893 9.56 FOXL2 NR5A1 SMARCA4 WT1
8 male gonad development GO:0008584 9.55 NR5A1 WT1
9 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.48 SMARCA4 WT1
10 female gonad development GO:0008585 9.43 FOXL2 NR5A1
11 tissue development GO:0009888 9.4 NR5A1 WT1
12 adrenal gland development GO:0030325 9.37 NR5A1 WT1
13 apoptotic DNA fragmentation GO:0006309 9.32 DICER1 FOXL2
14 transcription by RNA polymerase II GO:0006366 9.26 NR5A1
15 positive regulation of male gonad development GO:2000020 9.16 NR5A1 WT1
16 sex determination GO:0007530 8.96 NR5A1 WT1
17 negative regulation of female gonad development GO:2000195 8.62 NR5A1 WT1

Molecular functions related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 FOXL2 NR5A1 WT1
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 8.62 NR5A1 SMARCA4

Sources for Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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