MCID: TST016
MIFTS: 27

Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Testicular Granulosa Cell Tumor:

Name: Testicular Granulosa Cell Tumor 12 15 17 72
Granulosa Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5331
NCIt 50 C6357
UMLS 72 C1336709

Summaries for Testicular Granulosa Cell Tumor

MalaCards based summary : Testicular Granulosa Cell Tumor, also known as granulosa cell tumor of testis, is related to juvenile type testicular granulosa cell tumor and adult type testicular granulosa cell tumor. An important gene associated with Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Glucocorticoid receptor regulatory network. Affiliated tissues include testis, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 juvenile type testicular granulosa cell tumor 32.1 WT1 SMARCA4 FOXL2 DICER1 AFP
2 adult type testicular granulosa cell tumor 12.7
3 maligant granulosa cell tumor of the ovary 10.3 FOXL2 DICER1
4 gynandroblastoma 10.3 FOXL2 DICER1
5 gonadal dysgenesis 10.2 WT1 FOXL2
6 kidney sarcoma 10.2 WT1 DICER1
7 cystic nephroma 10.1 WT1 DICER1
8 reproductive organ benign neoplasm 10.1 DICER1 AFP
9 corpus luteum cyst 10.1 FOXL2 AFP
10 kidney benign neoplasm 10.1 WT1 DICER1
11 ovarian cyst 10.0 FOXL2 AFP
12 ovarian small cell carcinoma 10.0 WT1 SMARCA4
13 bladder cancer 10.0
14 infant gynecomastia 10.0
15 gynecomastia 10.0
16 testicular cancer 10.0
17 rare tumor 10.0
18 tumor predisposition syndrome 10.0 SMARCA4 DICER1
19 rhabdoid cancer 10.0 WT1 SMARCA4
20 dysgerminoma 10.0 WT1 AFP
21 gonadoblastoma 10.0 WT1 FOXL2
22 adenomatoid tumor 9.9 WT1 AFP
23 pineoblastoma 9.9 DICER1 AFP
24 nephrotic syndrome, type 1 9.8 WT1 AFP
25 testicular disease 9.8 DICER1 AFP
26 46,xy partial gonadal dysgenesis 9.8 WT1 GATA4
27 gonadal disease 9.7 FOXL2 AFP
28 mixed germ cell-sex cord neoplasm 9.7 WT1 GATA4
29 sertoli-leydig cell tumor 9.6 WT1 DICER1 AFP
30 premature ovarian failure 1 9.6 WT1 FOXL2
31 dysgerminoma of ovary 9.6 WT1 DICER1 AFP
32 diaphragmatic hernia, congenital 9.5 WT1 GATA4
33 male reproductive organ benign neoplasm 9.3 WT1 FOXL2 DICER1 AFP
34 sex cord-gonadal stromal tumor 9.3 WT1 FOXL2 DICER1 AFP

Graphical network of the top 20 diseases related to Testicular Granulosa Cell Tumor:



Diseases related to Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Testicular Granulosa Cell Tumor

MGI Mouse Phenotypes related to Testicular Granulosa Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.95 AFP DICER1 FOXL2 GATA4 SMARCA4 WT1
2 homeostasis/metabolism MP:0005376 9.93 AFP DICER1 FOXL2 GATA4 SMARCA4 WT1
3 mortality/aging MP:0010768 9.88 AFP DICER1 FOXL2 GATA4 SMARCA4 WT1
4 liver/biliary system MP:0005370 9.83 AFP DICER1 GATA4 SMARCA4 WT1
5 muscle MP:0005369 9.67 DICER1 GATA4 SMARCA4 WT1
6 neoplasm MP:0002006 9.62 AFP DICER1 SMARCA4 WT1
7 no phenotypic analysis MP:0003012 9.56 DICER1 FOXL2 GATA4 WT1
8 normal MP:0002873 9.55 DICER1 FOXL2 GATA4 SMARCA4 WT1
9 reproductive system MP:0005389 9.35 AFP DICER1 FOXL2 GATA4 WT1
10 respiratory system MP:0005388 8.92 DICER1 GATA4 SMARCA4 WT1

Drugs & Therapeutics for Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Granulosa Cell Tumor

Genetic Tests for Testicular Granulosa Cell Tumor

Anatomical Context for Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Testicular Granulosa Cell Tumor:

41
Testis

Publications for Testicular Granulosa Cell Tumor

Articles related to Testicular Granulosa Cell Tumor:

(show all 16)
# Title Authors PMID Year
1
Adult granulosa cell tumor of the testis masquerading as hydrocele. 38
26742984 2015
2
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor. 38
25308008 2014
3
Adult type granulosa cell tumor of the testis: Radiological evaluation and review of the literature. 38
26328162 2014
4
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. 38
21204721 2011
5
Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. 38
19777766 2009
6
Three-month-old boy with juvenile granulosa cell tumor of testis and ossifying renal tumor of infancy. 38
19573898 2009
7
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. 38
18984797 2008
8
Testicular granulosa cell tumor, adult type. 38
18723972 2008
9
Juvenile granulosa cell tumor of testis: case report and review of literature. 38
18548396 2008
10
Testicular granulosa cell tumor of adult type: a new case and a review of the literature. 38
17628299 2007
11
Adult-type testicular granulosa cell tumor: case report and review of the literature. 38
17095056 2006
12
Granulosa cell tumor of the contralateral testis in a man with a history of cryptorchism. 38
14730174 2004
13
Granulosa cell tumor of scrotal tunics: a case report. 38
11752981 2001
14
Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor. 38
11035589 2000
15
Testicular granulosa cell tumor of the adult type. 38
1536615 1992
16
Leontiasis ossea, slipped epiphyses, and granulosa cell tumor of testis with renal disease; report of a case with autopsy findings. 38
13091594 1953

Variations for Testicular Granulosa Cell Tumor

Expression for Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Testicular Granulosa Cell Tumor.

Pathways for Testicular Granulosa Cell Tumor

Pathways related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 WT1 SMARCA4 GATA4 AFP
2 10.87 SMARCA4 AFP

GO Terms for Testicular Granulosa Cell Tumor

Biological processes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.76 WT1 SMARCA4 GATA4 FOXL2
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.67 WT1 SMARCA4 GATA4 FOXL2
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.62 WT1 SMARCA4 FOXL2 DICER1
4 negative regulation of transcription, DNA-templated GO:0045892 9.61 WT1 SMARCA4 FOXL2
5 male gonad development GO:0008584 9.4 WT1 GATA4
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.26 WT1 SMARCA4
7 positive regulation of transcription, DNA-templated GO:0045893 9.26 WT1 SMARCA4 GATA4 FOXL2
8 tissue development GO:0009888 8.85 WT1
9 apoptotic DNA fragmentation GO:0006309 8.62 FOXL2 DICER1

Molecular functions related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.8 SMARCA4 GATA4 FOXL2

Sources for Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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