MCID: TST016
MIFTS: 30

Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Testicular Granulosa Cell Tumor:

Name: Testicular Granulosa Cell Tumor 12 15 17 71
Testicular Granulosa Cell Tumour 12
Granulosa Cell Tumour of Testis 12
Granulosa Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5331
NCIt 49 C6357
UMLS 71 C1336709

Summaries for Testicular Granulosa Cell Tumor

MalaCards based summary : Testicular Granulosa Cell Tumor, also known as testicular granulosa cell tumour, is related to adult type testicular granulosa cell tumor and juvenile type testicular granulosa cell tumor. An important gene associated with Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and BRCA1 Pathway. Affiliated tissues include testis and bone, and related phenotypes are mortality/aging and endocrine/exocrine gland

Related Diseases for Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 adult type testicular granulosa cell tumor 34.6 FOXL2 CALB2 AFP
2 juvenile type testicular granulosa cell tumor 29.4 WT1 SMARCB1 SMARCA4 SMARCA2 MIR302C INTS13
3 corpus luteum cyst 10.4 FOXL2 AFP
4 maligant granulosa cell tumor of the ovary 10.4 FOXL2 DICER1
5 rete testis neoplasm 10.4 CALB2 AFP
6 rete testis adenocarcinoma 10.4 CALB2 AFP
7 dermoid cyst of ovary 10.4 CALB2 AFP
8 papillary thymic adenocarcinoma 10.4 CALB2 AFP
9 infected hydrocele 10.4 CALB2 AFP
10 luteoma 10.4 FOXL2 CALB2
11 hydrocele 10.4 CALB2 AFP
12 non-gestational choriocarcinoma 10.4 MIR302C AFP
13 pediatric germ cell cancer 10.4 MIR302C AFP
14 botryoid rhabdomyosarcoma 10.4 DICER1 AFP
15 adenofibroma 10.4 WT1 CALB2
16 cystic lymphangioma 10.3 CALB2 AFP
17 choriocarcinoma of the testis 10.3 INTS13 AFP
18 fallopian tube carcinosarcoma 10.3 WT1 CALB2
19 mixed gonadal dysgenesis 10.3 MIR302C FOXL2
20 wolffian duct adenocarcinoma 10.3 WT1 CALB2
21 malignant biphasic mesothelioma 10.3 WT1 CALB2
22 pericardium cancer 10.3 WT1 CALB2
23 ovarian mixed germ cell neoplasm 10.3 WT1 AFP
24 ovarian endometrioid stromal sarcoma 10.3 WT1 CALB2
25 endosalpingiosis 10.3 WT1 CALB2
26 chondrodysplasia-pseudohermaphroditism syndrome 10.3 WT1 FOXL2
27 monophasic synovial sarcoma 10.3 CD99 CALB2
28 ovarian germ cell teratoma 10.3 MIR302C CALB2 AFP
29 middle ear carcinoma 10.3 WT1 AFP
30 peritoneal serous adenocarcinoma 10.3 WT1 CALB2
31 kidney sarcoma 10.3 WT1 DICER1
32 ovarian germ cell cancer 10.2 MIR302C CALB2 AFP
33 gynandroblastoma 10.2 FOXL2 DICER1 CALB2
34 endometrioid ovary carcinoma 10.2 WT1 SMARCA4
35 benign peritoneal mesothelioma 10.2 WT1 CALB2
36 mature teratoma 10.2 MIR302C AFP
37 large cell carcinoma with rhabdoid phenotype 10.2 SMARCB1 CALB2
38 heart cancer 10.2 WT1 CALB2
39 enamel erosion 10.2 SMARCA4 SMARCA2
40 pineal region teratoma 10.2 SMARCB1 AFP
41 wilms tumor predisposition 10.2 WT1 DICER1
42 tooth erosion 10.2 SMARCA4 SMARCA2
43 nephrotic syndrome, type 1 10.2 WT1 AFP
44 kidney cortex disease 10.2 WT1 DICER1
45 kidney rhabdoid cancer 10.2 SMARCB1 SMARCA4
46 malignant teratoma 10.2 MIR302C CD99 AFP
47 root caries 10.2 SMARCA4 SMARCA2
48 spinal canal and spinal cord meningioma 10.2 SMARCB1 SMARCA4
49 spinal meningioma 10.2 SMARCB1 SMARCA4
50 peritoneum cancer 10.2 WT1 CALB2

Graphical network of the top 20 diseases related to Testicular Granulosa Cell Tumor:



Diseases related to Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Testicular Granulosa Cell Tumor

MGI Mouse Phenotypes related to Testicular Granulosa Cell Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.02 AFP BMPR1B DICER1 FOXL2 GNAS SMAD5
2 endocrine/exocrine gland MP:0005379 10.01 AFP BMPR1B DICER1 FOXL2 GNAS SMARCA2
3 liver/biliary system MP:0005370 9.85 AFP DICER1 GNAS SMARCA4 SMARCB1 WT1
4 muscle MP:0005369 9.8 DICER1 GNAS SMAD5 SMARCA2 SMARCA4 SMARCB1
5 neoplasm MP:0002006 9.76 AFP DICER1 GNAS SMAD5 SMARCA2 SMARCA4
6 normal MP:0002873 9.56 BMPR1B CALB2 DICER1 FOXL2 GNAS SMAD5
7 reproductive system MP:0005389 9.23 AFP BMPR1B DICER1 FOXL2 SMAD5 SMARCA2

Drugs & Therapeutics for Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Granulosa Cell Tumor

Genetic Tests for Testicular Granulosa Cell Tumor

Anatomical Context for Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Testicular Granulosa Cell Tumor:

40
Testis, Bone

Publications for Testicular Granulosa Cell Tumor

Articles related to Testicular Granulosa Cell Tumor:

(show all 17)
# Title Authors PMID Year
1
Retrospective review of neoplasms of captive lizards in the United Kingdom. 61
31554709 2020
2
Adult testicular granulosa cell tumour: an extremely rare entity. 61
30389736 2018
3
Patient characteristics, patterns of care and survival outcome in patients with adult testicular granulosa cell tumour: An individual patient data meta-analysis. 61
32178141 2018
4
Adult granulosa cell tumor of the testis masquerading as hydrocele. 61
26742984 2015
5
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor. 61
25308008 2014
6
Adult type granulosa cell tumor of the testis: Radiological evaluation and review of the literature. 61
26328162 2014
7
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. 61
21204721 2011
8
Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. 61
19777766 2009
9
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. 61
18984797 2008
10
Testicular granulosa cell tumor, adult type. 61
18723972 2008
11
Testicular granulosa cell tumor of adult type: a new case and a review of the literature. 61
17628299 2007
12
Adult-type testicular granulosa cell tumor: case report and review of the literature. 61
17095056 2006
13
Adult granulosa cell tumour of the testis and bony metastasis. A report of the first case of granulosa cell tumour of the testicle metastasising to bone. 61
16037716 2005
14
Granulosa cell tumor of the contralateral testis in a man with a history of cryptorchism. 61
14730174 2004
15
Granulosa cell tumor of scrotal tunics: a case report. 61
11752981 2001
16
Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor. 61
11035589 2000
17
Testicular granulosa cell tumor of the adult type. 61
1536615 1992

Variations for Testicular Granulosa Cell Tumor

Expression for Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Testicular Granulosa Cell Tumor.

Pathways for Testicular Granulosa Cell Tumor

Pathways related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 WT1 SMARCA4 AFP
2
Show member pathways
11.25 SMARCB1 SMARCA4 SMARCA2
3
Show member pathways
11.16 SMARCB1 SMARCA4 SMARCA2 GNAS
4
Show member pathways
10.98 SMARCB1 SMARCA4 SMARCA2
5 10.66 SMAD5 BMPR1B

GO Terms for Testicular Granulosa Cell Tumor

Cellular components related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.65 SMARCB1 SMARCA4 SMARCA2 SMAD5 FOXL2
2 dendrite GO:0030425 9.62 GNAS DICER1 CALB2 BMPR1B
3 SWI/SNF complex GO:0016514 9.33 SMARCB1 SMARCA4 SMARCA2
4 nBAF complex GO:0071565 9.13 SMARCB1 SMARCA4 SMARCA2
5 npBAF complex GO:0071564 8.8 SMARCB1 SMARCA4 SMARCA2

Biological processes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.95 WT1 SMARCB1 SMARCA4 SMARCA2 FOXL2
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 WT1 SMARCA4 SMARCA2 SMAD5 FOXL2
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.73 WT1 SMARCA4 SMARCA2 SMAD5 FOXL2 DICER1
4 negative regulation of cell growth GO:0030308 9.7 WT1 SMARCA4 SMARCA2
5 chromatin remodeling GO:0006338 9.65 SMARCB1 SMARCA4 SMARCA2
6 germ cell development GO:0007281 9.56 WT1 SMAD5
7 nucleosome disassembly GO:0006337 9.54 SMARCB1 SMARCA4
8 cartilage development GO:0051216 9.54 SMAD5 GNAS BMPR1B
9 positive regulation by host of viral transcription GO:0043923 9.51 SMARCB1 SMARCA4
10 positive regulation of osteoblast differentiation GO:0045669 9.5 SMAD5 GNAS BMPR1B
11 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 WT1 SMARCB1 SMARCA4 SMARCA2 SMAD5 FOXL2
12 apoptotic DNA fragmentation GO:0006309 9.49 FOXL2 DICER1
13 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.43 SMARCB1 SMARCA4
14 RNA polymerase I preinitiation complex assembly GO:0001188 9.4 SMARCB1 SMARCA4
15 positive regulation of glucose mediated signaling pathway GO:1902661 9.16 SMARCB1 SMARCA4
16 ATP-dependent chromatin remodeling GO:0043044 8.8 SMARCB1 SMARCA4 SMARCA2

Molecular functions related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.87 WT1 SMARCB1 SMARCA4 SMARCA2 SMAD5 FOXL2
2 helicase activity GO:0004386 9.43 SMARCA4 SMARCA2 DICER1
3 Tat protein binding GO:0030957 9.16 SMARCB1 SMARCA4
4 hydrolase activity, acting on acid anhydrides GO:0016817 8.96 SMARCA4 SMARCA2
5 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 8.62 SMARCB1 SMARCA4

Sources for Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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