MCID: TST016
MIFTS: 29

Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Testicular Granulosa Cell Tumor:

Name: Testicular Granulosa Cell Tumor 12 15 17 71
Granulosa Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5331
NCIt 49 C6357
UMLS 71 C1336709

Summaries for Testicular Granulosa Cell Tumor

MalaCards based summary : Testicular Granulosa Cell Tumor, also known as granulosa cell tumor of testis, is related to adult type testicular granulosa cell tumor and juvenile type testicular granulosa cell tumor. An important gene associated with Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways are Hippo signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, ovary and kidney, and related phenotypes are endocrine/exocrine gland and neoplasm

Related Diseases for Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 adult type testicular granulosa cell tumor 34.0 MLANA FOXL2 CALB2 AFP
2 juvenile type testicular granulosa cell tumor 29.3 WT1 SMARCA4 MLANA MIR302C INTS13 GNAS
3 maligant granulosa cell tumor of the ovary 10.5 FOXL2 DICER1
4 mixed germ cell-sex cord neoplasm 10.4 FOXL2 CALB2
5 malignant sertoli cell tumor 10.4 CALB2 AFP
6 mature teratoma 10.4 MIR302C AFP
7 rete testis neoplasm 10.4 CALB2 AFP
8 rete testis adenocarcinoma 10.4 CALB2 AFP
9 hematocele of tunica vaginalis testis 10.4 CALB2 AFP
10 adenofibroma 10.4 WT1 CALB2
11 scrotum neoplasm 10.4 CALB2 AFP
12 infected hydrocele 10.4 CALB2 AFP
13 hydrocele 10.4 CALB2 AFP
14 non-gestational choriocarcinoma 10.4 MIR302C AFP
15 fallopian tube carcinosarcoma 10.4 WT1 CALB2
16 peritoneal serous adenocarcinoma 10.4 WT1 CALB2
17 malignant epithelial mesothelioma 10.4 WT1 CALB2
18 botryoid rhabdomyosarcoma 10.4 DICER1 AFP
19 malignant biphasic mesothelioma 10.4 WT1 CALB2
20 tuberculous epididymitis 10.4 CALB2 AFP
21 wolffian duct adenocarcinoma 10.4 WT1 CALB2
22 middle ear carcinoma 10.4 CALB2 AFP
23 choriocarcinoma of the testis 10.3 INTS13 AFP
24 pericardium cancer 10.3 WT1 CALB2
25 ovarian gonadoblastoma 10.3 WT1 AFP
26 liver leiomyosarcoma 10.3 WT1 AFP
27 mixed germ cell cancer 10.3 INTS13 AFP
28 cystic lymphangioma 10.3 CALB2 AFP
29 endosalpingiosis 10.3 WT1 CALB2
30 kidney sarcoma 10.3 WT1 DICER1
31 pineal gland cancer 10.3 DICER1 AFP
32 ovarian melanoma 10.3 MLANA CALB2
33 chondrodysplasia-pseudohermaphroditism syndrome 10.3 WT1 FOXL2
34 gynandroblastoma 10.3 FOXL2 DICER1 CALB2
35 mature teratoma of the ovary 10.3 MLANA AFP
36 ovarian germ cell teratoma 10.3 MIR302C CALB2 AFP
37 ovarian germ cell cancer 10.3 MIR302C CALB2 AFP
38 hepatic angiomyolipoma 10.3 MLANA AFP
39 central nervous system primitive neuroectodermal neoplasm 10.3 DICER1 CD99
40 wilms tumor predisposition 10.3 WT1 DICER1
41 retroperitoneal sarcoma 10.2 MLANA CALB2
42 medulloepithelioma 10.2 DICER1 CALB2
43 cervical serous adenocarcinoma 10.2 WT1 MLANA
44 thymus clear cell carcinoma 10.2 MLANA CALB2
45 spermatocele 10.2 CALB2 AMHR2
46 malignant teratoma 10.2 MIR302C CD99 AFP
47 nephrotic syndrome, type 1 10.2 WT1 AFP
48 microcystic stromal tumor 10.2 WT1 FOXL2 DICER1
49 epididymal neoplasm 10.2 WT1 CALB2 AFP
50 benign mesothelioma 10.2 WT1 CALB2 AFP

Graphical network of the top 20 diseases related to Testicular Granulosa Cell Tumor:



Diseases related to Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Testicular Granulosa Cell Tumor

MGI Mouse Phenotypes related to Testicular Granulosa Cell Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.91 AFP AMH AMHR2 BMPR1B DICER1 FOXL2
2 neoplasm MP:0002006 9.7 AFP AMH AMHR2 DICER1 GNAS SMARCA4
3 no phenotypic analysis MP:0003012 9.5 AMH AMHR2 DICER1 FOXL2 GNAS MLANA
4 normal MP:0002873 9.17 BMPR1B CALB2 DICER1 FOXL2 GNAS SMARCA4

Drugs & Therapeutics for Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Granulosa Cell Tumor

Genetic Tests for Testicular Granulosa Cell Tumor

Anatomical Context for Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Testicular Granulosa Cell Tumor:

40
Testis, Ovary, Kidney, Thymus, Liver, Pineal

Publications for Testicular Granulosa Cell Tumor

Articles related to Testicular Granulosa Cell Tumor:

(show all 16)
# Title Authors PMID Year
1
Adult granulosa cell tumor of the testis masquerading as hydrocele. 61
26742984 2015
2
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor. 61
25308008 2014
3
Adult type granulosa cell tumor of the testis: Radiological evaluation and review of the literature. 61
26328162 2014
4
Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. 61
21204721 2011
5
Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. 61
19777766 2009
6
Three-month-old boy with juvenile granulosa cell tumor of testis and ossifying renal tumor of infancy. 61
19573898 2009
7
Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. 61
18984797 2008
8
Testicular granulosa cell tumor, adult type. 61
18723972 2008
9
Juvenile granulosa cell tumor of testis: case report and review of literature. 61
18548396 2008
10
Testicular granulosa cell tumor of adult type: a new case and a review of the literature. 61
17628299 2007
11
Adult-type testicular granulosa cell tumor: case report and review of the literature. 61
17095056 2006
12
Granulosa cell tumor of the contralateral testis in a man with a history of cryptorchism. 61
14730174 2004
13
Granulosa cell tumor of scrotal tunics: a case report. 61
11752981 2001
14
Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor. 61
11035589 2000
15
Testicular granulosa cell tumor of the adult type. 61
1536615 1992
16
Leontiasis ossea, slipped epiphyses, and granulosa cell tumor of testis with renal disease; report of a case with autopsy findings. 61
13091594 1953

Variations for Testicular Granulosa Cell Tumor

Expression for Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Testicular Granulosa Cell Tumor.

Pathways for Testicular Granulosa Cell Tumor

Pathways related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 BMPR1B AMH AFP
2 11.46 WT1 SMARCA4 AFP
3 11.1 BMPR1B AMHR2 AMH
4 9.66 AMHR2 AMH

GO Terms for Testicular Granulosa Cell Tumor

Cellular components related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.92 GNAS DICER1 CALB2 BMPR1B

Biological processes related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 WT1 SMARCA4
2 female gonad development GO:0008585 9.43 FOXL2 AMHR2
3 sex differentiation GO:0007548 9.4 AMHR2 AMH
4 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.37 BMPR1B AMHR2
5 BMP signaling pathway GO:0030509 9.33 BMPR1B AMHR2 AMH
6 apoptotic DNA fragmentation GO:0006309 9.32 FOXL2 DICER1
7 gonad development GO:0008406 9.26 WT1 AMH
8 sex determination GO:0007530 8.96 WT1 AMH
9 Mullerian duct regression GO:0001880 8.62 AMHR2 AMH

Molecular functions related to Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 BMPR1B AMHR2

Sources for Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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