MCID: TST007
MIFTS: 29

Testicular Infarct

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Infarct

MalaCards integrated aliases for Testicular Infarct:

Name: Testicular Infarct 12 15
Infarction of Testis 12 72
Testicular Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5104
NCIt 50 C27617
SNOMED-CT 68 33793000
UMLS 72 C0392041

Summaries for Testicular Infarct

MalaCards based summary : Testicular Infarct, also known as infarction of testis, is related to mastoiditis and brain germinoma. An important gene associated with Testicular Infarct is PHYH (Phytanoyl-CoA 2-Hydroxylase), and among its related pathways/superpathways are Selenium Micronutrient Network and Wnt / Hedgehog / Notch. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and appendix, and related phenotype is liver/biliary system.

Related Diseases for Testicular Infarct

Diseases related to Testicular Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 mastoiditis 10.4 MTHFR CRP
2 brain germinoma 10.4 POU5F1 AFP
3 extragonadal germ cell cancer 10.4 POU5F1 AFP
4 ischemic neuropathy 10.4 MTHFR CRP
5 embryonal testis carcinoma 10.4 POU5F1 AFP
6 central nervous system germ cell tumor 10.4 POU5F1 AFP
7 malignant teratoma 10.4 POU5F1 AFP
8 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.4 PTPRC PHYH
9 hemoglobin c disease 10.4 MTHFR HBB
10 mature teratoma 10.4 POU5F1 AFP
11 pineoblastoma 10.4 POU5F1 AFP
12 lemierre's syndrome 10.3 MTHFR CRP
13 testicular torsion 10.3
14 calcific tendinitis 10.3 UCHL1 CRP
15 gastric small cell carcinoma 10.3 UCHL1 PTPRC
16 riboflavin deficiency 10.3 MTHFR CRP
17 blood protein disease 10.3 MTHFR HBB
18 inguinal hernia 10.3
19 liver lymphoma 10.3 FUT4 AFP
20 arteritic anterior ischemic optic neuropathy 10.3 MTHFR CRP
21 dental abscess 10.3 KIT CRP
22 pyosalpinx 10.3 KIT CRP
23 orchitis 10.3
24 small intestine lymphoma 10.3 UCHL1 PTPRC
25 epididymo-orchitis 10.2
26 chorioangioma 10.2 FUT4 AFP
27 diverticulitis of colon 10.2 UCHL1 KIT
28 portal vein thrombosis 10.2 MTHFR AFP
29 mixed germ cell tumor 10.2 KIT AFP
30 hepatic angiomyolipoma 10.2 KIT AFP
31 hepatic vascular disease 10.2 MTHFR AFP
32 hemangioma of intra-abdominal structure 10.2 FUT4 AFP
33 mixed germ cell-sex cord neoplasm 10.2 POU5F1 KIT
34 mediastinal cancer 10.2 KIT AFP
35 rete testis adenocarcinoma 10.2 KIT AFP
36 vasculitis 10.1
37 sickle cell disease 10.1
38 nondisjunction 10.1 MTHFR KIT
39 hodgkin's lymphoma, mixed cellularity 10.1 UCHL1 PTPRC PHYH
40 rete testis neoplasm 10.1 KIT AFP
41 gamma heavy chain disease 10.1 PTPRC FUT4
42 extracutaneous mastocytoma 10.1 PTPRC KIT
43 alpha thalassemia-intellectual disability syndrome type 1 10.1 MTHFR HBB
44 lichen nitidus 10.1 UCHL1 TNFRSF8
45 gastric cardia carcinoma 10.1 MTHFR KIT
46 vein disease 10.1 MTHFR AFP
47 ovarian solid teratoma 10.0 TNFRSF8 AFP
48 malignant mesenchymoma 10.0 UCHL1 KIT
49 testicular cancer 10.0
50 purpura 10.0

Graphical network of the top 20 diseases related to Testicular Infarct:



Diseases related to Testicular Infarct

Symptoms & Phenotypes for Testicular Infarct

MGI Mouse Phenotypes related to Testicular Infarct:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 AFP KIT MTHFR PHYH POU5F1 PTPRC

Drugs & Therapeutics for Testicular Infarct

Drugs for Testicular Infarct (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents
2 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637

Search NIH Clinical Center for Testicular Infarct

Genetic Tests for Testicular Infarct

Anatomical Context for Testicular Infarct

MalaCards organs/tissues related to Testicular Infarct:

41
Testis, Ovary, Appendix

Publications for Testicular Infarct

Articles related to Testicular Infarct:

(show all 25)
# Title Authors PMID Year
1
[Rare clinical course of epididymo-orchitis with subtotal testicular infarct]. 38
26114253 2015
2
Identify Before Orchiectomy: Segmental Testicular Infarct. 38
25945726 2015
3
Segmental testicular infarction due to minocycline-induced antineutrophil cytoplasmic antibody--positive vasculitis. 38
24793001 2014
4
Multidrug resistant epididymitis progressing to testicular infarct and orchiectomy. 38
24379982 2013
5
Imaging of non-neoplastic intratesticular masses. 38
20677130 2011
6
Segmental Infarction of Testis: A rare complication of acute epididymitis. 38
28845218 2010
7
US MR imaging correlation in pathologic conditions of the scrotum. 38
17848688 2007
8
Localized traumatic infarction of the testicle. 38
15764261 2004
9
[A rare case of acute scrotum. Thrombophlebitis from ectasia of the left pampiniforme plexus]. 38
10638181 1999
10
[Isolated vasculitis of the spermatic cord]. 38
10510712 1999
11
Segmental hemorrhagic infarction of testis associated with epididymitis. 38
9641396 1998
12
[Testicular infarct simulating a neoplasms]. 38
9586321 1998
13
[Testicular infarction as a cause of benign intrascrotal tumor]. 38
8678606 1996
14
Oversized "bullseye" with central activity. A scintigraphic appearance of hemorrhagic testicular infarct following traumatic rupture of the testicle. 38
8403724 1993
15
[Segmental ischemic testicular infarct. The echographic and histological correlations]. 38
2697036 1989
16
[Testicular echography in torsion and epididymitis. Apropos of 2 cases]. 38
3058956 1988
17
Postsurgical focal testicular infarct. 38
3727192 1986
18
[A case of bilateral testicular infarction without spermatic torsion]. 38
6507211 1984
19
[Testicular infarct secondary to strangulated inguinal hernia in childhood]. 38
7360353 1980
20
[Irreversible infarction of testis and ovary due to incarcerated inguinal hernia in the newborn]. 38
888586 1977
21
[Differential diagnosis: testicular neoplasms--idiopathic testicular infarct]. 38
5758809 1968
22
[Testicular infarct in rheumatoid purpura]. 38
5619178 1967
23
Total granulomatous infarction of testis due to Schistosoma haematobium. 38
5602560 1967
24
Hemorrhagic infarction of testis in newborn; relationship to testicular torsion. 38
13227600 1955
25
[Testicular infarct and torsion of the appendix testis in children]. 38
14942149 1952

Variations for Testicular Infarct

Expression for Testicular Infarct

Search GEO for disease gene expression data for Testicular Infarct.

Pathways for Testicular Infarct

Pathways related to Testicular Infarct according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.67 MTHFR HBB CRP
2 11.39 POU5F1 FUT4 AFP
3 10.52 TNFRSF8 PTPRC KIT

GO Terms for Testicular Infarct

Biological processes related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 8.96 POU5F1 KIT
2 T cell differentiation GO:0030217 8.62 PTPRC KIT

Molecular functions related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 POU5F1 KIT

Sources for Testicular Infarct

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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