MCID: TST007
MIFTS: 27

Testicular Infarct

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Infarct

MalaCards integrated aliases for Testicular Infarct:

Name: Testicular Infarct 12 15
Infarction of Testis 12 74
Testicular Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5104
NCIt 51 C27617
SNOMED-CT 69 33793000
UMLS 74 C0392041

Summaries for Testicular Infarct

MalaCards based summary : Testicular Infarct, also known as infarction of testis, is related to brain germinoma and extragonadal germ cell cancer. An important gene associated with Testicular Infarct is PHYH (Phytanoyl-CoA 2-Hydroxylase), and among its related pathways/superpathways are Selenium Micronutrient Network and Wnt / Hedgehog / Notch. Affiliated tissues include testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Testicular Infarct

Diseases related to Testicular Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 brain germinoma 10.3 AFP POU5F1
2 extragonadal germ cell cancer 10.3 AFP POU5F1
3 central nervous system germ cell tumor 10.3 AFP POU5F1
4 embryonal testis carcinoma 10.3 AFP POU5F1
5 hemoglobin c disease 10.3 HBB MTHFR
6 malignant teratoma 10.3 AFP POU5F1
7 mature teratoma 10.3 AFP POU5F1
8 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 PHYH PTPRC
9 pineoblastoma 10.2 AFP POU5F1
10 mastoiditis 10.2 CRP MTHFR
11 ischemic neuropathy 10.2 CRP MTHFR
12 blood protein disease 10.2 HBB MTHFR
13 gastric small cell carcinoma 10.2 PTPRC UCHL1
14 calcific tendinitis 10.2 CRP UCHL1
15 ischemic heart disease 10.2 CRP MTHFR
16 liver lymphoma 10.2 AFP FUT4
17 lemierre's syndrome 10.2 CRP MTHFR
18 small intestine lymphoma 10.2 PTPRC UCHL1
19 riboflavin deficiency 10.2 CRP MTHFR
20 diverticulitis of colon 10.1 KIT UCHL1
21 chorioangioma 10.1 AFP FUT4
22 portal vein thrombosis 10.1 AFP MTHFR
23 dental abscess 10.1 CRP KIT
24 arteritic anterior ischemic optic neuropathy 10.1 CRP MTHFR
25 mixed germ cell tumor 10.1 AFP KIT
26 mixed germ cell-sex cord neoplasm 10.1 KIT POU5F1
27 pyosalpinx 10.1 CRP KIT
28 hepatic angiomyolipoma 10.1 AFP KIT
29 hepatic vascular disease 10.1 AFP MTHFR
30 hemangioma of intra-abdominal structure 10.1 AFP FUT4
31 rete testis adenocarcinoma 10.1 AFP KIT
32 mediastinal cancer 10.1 AFP KIT
33 alpha thalassemia-intellectual disability syndrome type 1 10.1 HBB MTHFR
34 nondisjunction 10.1 KIT MTHFR
35 orchitis 10.1
36 epididymo-orchitis 10.1
37 gamma heavy chain disease 10.1 FUT4 PTPRC
38 hodgkin's lymphoma, mixed cellularity 10.1 PHYH PTPRC UCHL1
39 rete testis neoplasm 10.1 AFP KIT
40 extracutaneous mastocytoma 10.1 KIT PTPRC
41 lichen nitidus 10.0 TNFRSF8 UCHL1
42 gastric cardia carcinoma 10.0 KIT MTHFR
43 vein disease 10.0 AFP MTHFR
44 testicular yolk sac tumor 10.0 AFP POU5F1
45 ovarian solid teratoma 10.0 AFP TNFRSF8
46 malignant mesenchymoma 10.0 KIT UCHL1
47 dysgerminoma of ovary 10.0 AFP KIT
48 mixed germ cell cancer 10.0 AFP FUT4 POU5F1
49 germ cell and embryonal cancer 10.0 AFP FUT4 POU5F1
50 dysgerminoma 10.0 AFP KIT

Graphical network of the top 20 diseases related to Testicular Infarct:



Diseases related to Testicular Infarct

Symptoms & Phenotypes for Testicular Infarct

GenomeRNAi Phenotypes related to Testicular Infarct according to GeneCards Suite gene sharing:

27 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.58 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.58 PTPRC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.58 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 MTHFR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.58 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.58 MTHFR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 CRP MTHFR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.58 PTPRC
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 MTHFR
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 CRP MTHFR PTPRC
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.58 MTHFR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.58 PTPRC
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.58 CRP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 MTHFR
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.58 MTHFR

MGI Mouse Phenotypes related to Testicular Infarct:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 AFP KIT MTHFR PHYH POU5F1 PTPRC

Drugs & Therapeutics for Testicular Infarct

Search Clinical Trials , NIH Clinical Center for Testicular Infarct

Genetic Tests for Testicular Infarct

Anatomical Context for Testicular Infarct

MalaCards organs/tissues related to Testicular Infarct:

42
Testis

Publications for Testicular Infarct

Articles related to Testicular Infarct:

# Title Authors Year
1
Identify Before Orchiectomy: Segmental Testicular Infarct. ( 25945726 )
2015
2
Multidrug resistant epididymitis progressing to testicular infarct and orchiectomy. ( 24379982 )
2013
3
Segmental Infarction of Testis: A rare complication of acute epididymitis. ( 28845218 )
2010
4
Segmental hemorrhagic infarction of testis associated with epididymitis. ( 9641396 )
1998
5
Oversized &amp;quot;bullseye&amp;quot; with central activity. A scintigraphic appearance of hemorrhagic testicular infarct following traumatic rupture of the testicle. ( 8403724 )
1993
6
Postsurgical focal testicular infarct. ( 3727192 )
1986
7
Total granulomatous infarction of testis due to Schistosoma haematobium. ( 5602560 )
1967
8
Hemorrhagic infarction of testis in newborn; relationship to testicular torsion. ( 13227600 )
1955

Variations for Testicular Infarct

Expression for Testicular Infarct

Search GEO for disease gene expression data for Testicular Infarct.

Pathways for Testicular Infarct

Pathways related to Testicular Infarct according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.67 CRP HBB MTHFR
2 11.39 AFP FUT4 POU5F1
3 10.52 KIT PTPRC TNFRSF8

GO Terms for Testicular Infarct

Biological processes related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 8.96 KIT POU5F1
2 T cell differentiation GO:0030217 8.62 KIT PTPRC

Molecular functions related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 KIT POU5F1

Sources for Testicular Infarct

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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