MCID: TST007
MIFTS: 28

Testicular Infarct

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Infarct

MalaCards integrated aliases for Testicular Infarct:

Name: Testicular Infarct 12 15
Infarction of Testis 12 73
Testicular Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5104
NCIt 50 C27617
SNOMED-CT 68 33793000
UMLS 73 C0392041

Summaries for Testicular Infarct

MalaCards based summary : Testicular Infarct, also known as infarction of testis, is related to brain germinoma and extragonadal germ cell cancer. An important gene associated with Testicular Infarct is PHYH (Phytanoyl-CoA 2-Hydroxylase), and among its related pathways/superpathways are Folate Metabolism and Wnt / Hedgehog / Notch. Affiliated tissues include testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Testicular Infarct

Diseases related to Testicular Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 brain germinoma 10.7 AFP POU5F1
2 extragonadal germ cell cancer 10.7 AFP POU5F1
3 central nervous system germ cell tumor 10.7 AFP POU5F1
4 embryonal testis carcinoma 10.7 AFP POU5F1
5 malignant teratoma 10.7 AFP POU5F1
6 mature teratoma 10.6 AFP POU5F1
7 pineoblastoma 10.6 AFP POU5F1
8 gastric small cell carcinoma 10.5 PTPRC UCHL1
9 liver lymphoma 10.5 AFP FUT4
10 small intestine lymphoma 10.5 PTPRC UCHL1
11 calcific tendinitis 10.4 CRP UCHL1
12 mastoiditis 10.4 CRP MTHFR
13 ischemic neuropathy 10.4 CRP MTHFR
14 chorioangioma 10.4 AFP FUT4
15 malignant biphasic mesothelioma 10.4 AFP FUT4
16 gastroschisis 10.4 AFP MTHFR
17 hemoglobin c disease 10.4 HBB MTHFR
18 mixed germ cell tumor 10.3 AFP KIT
19 diverticulitis of colon 10.3 KIT UCHL1
20 hepatic angiomyolipoma 10.3 AFP KIT
21 hemangioma of intra-abdominal structure 10.3 AFP FUT4
22 lemierre's syndrome 10.3 CRP MTHFR
23 rete testis adenocarcinoma 10.3 AFP KIT
24 mediastinal cancer 10.3 AFP KIT
25 hodgkin's lymphoma, mixed cellularity 10.3 PHYH PTPRC UCHL1
26 testicular yolk sac tumor 10.3 AFP POU5F1
27 dental abscess 10.3 CRP KIT
28 portal vein thrombosis 10.3 AFP MTHFR
29 riboflavin deficiency 10.3 CRP MTHFR
30 pyosalpinx 10.3 CRP KIT
31 rete testis neoplasm 10.3 AFP KIT
32 hepatic vascular disease 10.2 AFP MTHFR
33 gamma heavy chain disease 10.2 FUT4 PTPRC
34 arteritic anterior ischemic optic neuropathy 10.2 CRP MTHFR
35 extracutaneous mastocytoma 10.2 KIT PTPRC
36 diffuse cutaneous mastocytosis 10.2 KIT PTPRC
37 sarcomatoid squamous cell skin carcinoma 10.2 KIT PTPRC
38 dysgerminoma of ovary 10.2 AFP KIT
39 vein disease 10.1 AFP MTHFR
40 nondisjunction 10.1 KIT MTHFR
41 lichen nitidus 10.1 TNFRSF8 UCHL1
42 ovarian solid teratoma 10.1 AFP TNFRSF8
43 malignant mesenchymoma 10.1 KIT UCHL1
44 mixed germ cell cancer 10.1 AFP FUT4 POU5F1
45 germ cell and embryonal cancer 10.1 AFP FUT4 POU5F1
46 epididymitis 10.1
47 uterine anomalies 10.0 AFP CRP MTHFR
48 myeloid sarcoma 10.0 KIT PTPRC
49 teratoma 10.0 AFP KIT POU5F1
50 cell type cancer 10.0 AFP KIT POU5F1

Graphical network of the top 20 diseases related to Testicular Infarct:



Diseases related to Testicular Infarct

Symptoms & Phenotypes for Testicular Infarct

GenomeRNAi Phenotypes related to Testicular Infarct according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.6 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.6 PTPRC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.6 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.6 MTHFR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.6 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.6 MTHFR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.6 CRP MTHFR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.6 PTPRC
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.6 MTHFR
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.6 CRP MTHFR PTPRC
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.6 MTHFR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.6 MTHFR
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.6 PTPRC
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.6 CRP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.6 MTHFR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.6 MTHFR

MGI Mouse Phenotypes related to Testicular Infarct:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 AFP KIT PHYH POU5F1 PTPRC UCHL1

Drugs & Therapeutics for Testicular Infarct

Search Clinical Trials , NIH Clinical Center for Testicular Infarct

Genetic Tests for Testicular Infarct

Anatomical Context for Testicular Infarct

MalaCards organs/tissues related to Testicular Infarct:

41
Testis

Publications for Testicular Infarct

Articles related to Testicular Infarct:

(show all 25)
# Title Authors Year
1
Epididymo-orchitis causing testicular infarction: a serious complication of a common disorder. ( 29423147 )
2017
2
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
3
A case of testicular infarction from the complications of Klebsiella oxytoca induced acute epididymitis. ( 26643901 )
2016
4
Testicular infarction and rupture: an uncommon complication of epididymo-orchitis. ( 27165751 )
2016
5
Identify Before Orchiectomy: Segmental Testicular Infarct. ( 25945726 )
2015
6
Serial Ultrasonography Assessments of a Testicular Infarction Mimicking Testicular Tumor in a Behcet Disease Patient. ( 26955543 )
2014
7
Testicular infarction after angioembolization of an ipsilateral renal angiomyolipoma. ( 23978372 )
2013
8
Global testicular infarction in the presence of epididymitis: clinical features, appearances on grayscale, color Doppler, and contrast-enhanced sonography, and histologic correlation. ( 23269723 )
2013
9
Multidrug resistant epididymitis progressing to testicular infarct and orchiectomy. ( 24379982 )
2013
10
Idiopathic testicular infarction in a boy initially suspected to have acute epididymo-orchitis associated with mycoplasma infection and Henoch-SchAPnlein purpura. ( 18753011 )
2009
11
Significance of reversal of diastolic blood flow in the evolution of testicular infarction as a complication of epididymo-orchitis. ( 22470666 )
2009
12
Segmental testicular infarction due to cholesterol embolism: not the first case, but the first report. ( 18844943 )
2008
13
Idiopathic testicular infarction initially masquerading as urolithiasis and epididymitis. ( 17606112 )
2007
14
Bilateral testicular infarction and orchiectomy as a complication of polyarteritis nodosa. ( 18231620 )
2007
15
Testicular infarction secondary to protein S deficiency: a case report. ( 16827935 )
2006
16
[Testicular infarction without torsion in cryptorchism]. ( 12765076 )
2003
17
Testicular infarction associated with protein S deficiency. ( 11257684 )
2001
18
Segmental hemorrhagic infarction of testis associated with epididymitis. ( 9641396 )
1998
19
Testicular infarction in a patient with epididymitis. ( 9835481 )
1998
20
Special imaging casebook. Neonatal spermatic cord torsion and testicular infarction. ( 7830162 )
1994
21
Malakoplakia of epididymis associated with testicular infarction. ( 10071557 )
1993
22
Oversized &amp;quot;bullseye&amp;quot; with central activity. A scintigraphic appearance of hemorrhagic testicular infarct following traumatic rupture of the testicle. ( 8403724 )
1993
23
Bilateral testicular infarction caused by epididymitis. ( 1872237 )
1991
24
Postsurgical focal testicular infarct. ( 3727192 )
1986
25
Evolution of acute epididymitis to testicular infarction. Scintigraphic demonstration. ( 3006965 )
1986

Variations for Testicular Infarct

Expression for Testicular Infarct

Search GEO for disease gene expression data for Testicular Infarct.

Pathways for Testicular Infarct

Pathways related to Testicular Infarct according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.66 CRP HBB MTHFR
2 11.39 AFP FUT4 POU5F1
3 10.52 KIT PTPRC TNFRSF8

GO Terms for Testicular Infarct

Biological processes related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell differentiation GO:0030217 8.62 KIT PTPRC

Molecular functions related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 KIT POU5F1

Sources for Testicular Infarct

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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