MCID: TST007
MIFTS: 32

Testicular Infarct

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Infarct

MalaCards integrated aliases for Testicular Infarct:

Name: Testicular Infarct 12 15
Infarction of Testis 12 73
Testicular Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5104
NCIt 50 C27617
SNOMED-CT 68 33793000
UMLS 73 C0392041

Summaries for Testicular Infarct

MalaCards based summary : Testicular Infarct, also known as infarction of testis, is related to brain germinoma and extragonadal germ cell cancer. An important gene associated with Testicular Infarct is PHYH (Phytanoyl-CoA 2-Hydroxylase), and among its related pathways/superpathways are Selenium Micronutrient Network and Wnt / Hedgehog / Notch. Affiliated tissues include testis, brain and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Testicular Infarct

Diseases related to Testicular Infarct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 brain germinoma 10.2 AFP POU5F1
2 extragonadal germ cell cancer 10.2 AFP POU5F1
3 central nervous system germ cell tumor 10.2 AFP POU5F1
4 embryonal testis carcinoma 10.2 AFP POU5F1
5 malignant teratoma 10.2 AFP POU5F1
6 mature teratoma 10.2 AFP POU5F1
7 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 PHYH PTPRC
8 pineoblastoma 10.2 AFP POU5F1
9 epididymitis 10.2
10 gastric small cell carcinoma 10.2 PTPRC UCHL1
11 calcific tendinitis 10.1 CRP UCHL1
12 small intestine lymphoma 10.1 PTPRC UCHL1
13 mastoiditis 10.1 CRP MTHFR
14 liver lymphoma 10.1 AFP FUT4
15 ischemic neuropathy 10.1 CRP MTHFR
16 hemoglobin c disease 10.1 HBB MTHFR
17 chorioangioma 10.1 AFP FUT4
18 ischemic heart disease 10.1 CRP MTHFR
19 diverticulitis of colon 10.1 KIT UCHL1
20 lemierre's syndrome 10.1 CRP MTHFR
21 mixed germ cell tumor 10.1 AFP KIT
22 dental abscess 10.1 CRP KIT
23 riboflavin deficiency 10.1 CRP MTHFR
24 hepatic angiomyolipoma 10.1 AFP KIT
25 mixed germ cell-sex cord neoplasm 10.1 KIT POU5F1
26 pyosalpinx 10.1 CRP KIT
27 hodgkin's lymphoma, mixed cellularity 10.1 PHYH PTPRC UCHL1
28 hemangioma of intra-abdominal structure 10.1 AFP FUT4
29 rete testis adenocarcinoma 10.1 AFP KIT
30 mediastinal cancer 10.1 AFP KIT
31 gamma heavy chain disease 10.1 FUT4 PTPRC
32 orchitis 10.1
33 epididymo-orchitis 10.1
34 portal vein thrombosis 10.1 AFP MTHFR
35 blood protein disease 10.1 HBB MTHFR
36 arteritic anterior ischemic optic neuropathy 10.1 CRP MTHFR
37 hepatic vascular disease 10.1 AFP MTHFR
38 rete testis neoplasm 10.1 AFP KIT
39 extracutaneous mastocytoma 10.1 KIT PTPRC
40 lichen nitidus 10.0 TNFRSF8 UCHL1
41 nondisjunction 10.0 KIT MTHFR
42 testicular yolk sac tumor 10.0 AFP POU5F1
43 ovarian solid teratoma 10.0 AFP TNFRSF8
44 mixed germ cell cancer 10.0 AFP FUT4 POU5F1
45 germ cell and embryonal cancer 10.0 AFP FUT4 POU5F1
46 malignant mesenchymoma 10.0 KIT UCHL1
47 dysgerminoma of ovary 10.0 AFP KIT
48 myeloid sarcoma 10.0 KIT PTPRC
49 dysgerminoma 10.0 AFP KIT
50 gastric cardia carcinoma 10.0 KIT MTHFR

Graphical network of the top 20 diseases related to Testicular Infarct:



Diseases related to Testicular Infarct

Symptoms & Phenotypes for Testicular Infarct

GenomeRNAi Phenotypes related to Testicular Infarct according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.6 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.6 PTPRC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.6 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.6 MTHFR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.6 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.6 MTHFR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.6 CRP MTHFR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.6 PTPRC
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.6 MTHFR
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.6 CRP MTHFR PTPRC
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.6 MTHFR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.6 MTHFR
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.6 PTPRC
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.6 CRP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.6 MTHFR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.6 MTHFR

MGI Mouse Phenotypes related to Testicular Infarct:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 AFP KIT MTHFR PHYH POU5F1 PTPRC

Drugs & Therapeutics for Testicular Infarct

Search Clinical Trials , NIH Clinical Center for Testicular Infarct

Genetic Tests for Testicular Infarct

Anatomical Context for Testicular Infarct

MalaCards organs/tissues related to Testicular Infarct:

41
Testis, Brain, Liver, Colon, Heart, Spinal Cord, Thymus

Publications for Testicular Infarct

Articles related to Testicular Infarct:

# Title Authors Year
1
Identify Before Orchiectomy: Segmental Testicular Infarct. ( 25945726 )
2015
2
Multidrug resistant epididymitis progressing to testicular infarct and orchiectomy. ( 24379982 )
2013
3
Segmental Infarction of Testis: A rare complication of acute epididymitis. ( 28845218 )
2010
4
Segmental hemorrhagic infarction of testis associated with epididymitis. ( 9641396 )
1998
5
Oversized &amp;quot;bullseye&amp;quot; with central activity. A scintigraphic appearance of hemorrhagic testicular infarct following traumatic rupture of the testicle. ( 8403724 )
1993
6
Postsurgical focal testicular infarct. ( 3727192 )
1986
7
Total granulomatous infarction of testis due to Schistosoma haematobium. ( 5602560 )
1967
8
Hemorrhagic infarction of testis in newborn; relationship to testicular torsion. ( 13227600 )
1955

Variations for Testicular Infarct

Expression for Testicular Infarct

Search GEO for disease gene expression data for Testicular Infarct.

Pathways for Testicular Infarct

Pathways related to Testicular Infarct according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.67 CRP HBB MTHFR
2 11.39 AFP FUT4 POU5F1
3 10.52 KIT PTPRC TNFRSF8

GO Terms for Testicular Infarct

Biological processes related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 8.96 KIT POU5F1
2 T cell differentiation GO:0030217 8.62 KIT PTPRC

Molecular functions related to Testicular Infarct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 KIT POU5F1

Sources for Testicular Infarct

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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