MCID: TST003
MIFTS: 35

Testicular Leukemia

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Leukemia

MalaCards integrated aliases for Testicular Leukemia:

Name: Testicular Leukemia 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12286
NCIt 51 C9277
UMLS 74 C1336711

Summaries for Testicular Leukemia

MalaCards based summary : Testicular Leukemia is related to leukemia and venous hemangioma. An important gene associated with Testicular Leukemia is MAGEA4 (MAGE Family Member A4), and among its related pathways/superpathways are Kit receptor signaling pathway and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs leucovorin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include monocytes, bone marrow and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Testicular Leukemia

Diseases related to Testicular Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 leukemia 10.4
2 venous hemangioma 10.1 POU5F1 WT1
3 mixed germ cell-sex cord neoplasm 10.1 POU5F1 WT1
4 orofacial granulomatosis 10.1 CCR3 CD79A
5 pediatric lymphoma 10.1 CD79A CD9
6 extragonadal seminoma 10.0 POU5F1 TFAP2C
7 lymphocytic leukemia 9.9
8 dysgerminoma of ovary 9.9 CD79A WT1
9 leukemia, acute monocytic 9.7
10 leukemia, acute lymphoblastic 9.7
11 acute lymphocytic leukemia 9.7
12 childhood leukemia 9.7
13 monocytic leukemia 9.7
14 acute monoblastic leukemia 9.7

Graphical network of the top 20 diseases related to Testicular Leukemia:



Diseases related to Testicular Leukemia

Symptoms & Phenotypes for Testicular Leukemia

GenomeRNAi Phenotypes related to Testicular Leukemia according to GeneCards Suite gene sharing:

27 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.77 TFAP2C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.77 CCR10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 GJB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.77 TFAP2C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.77 CCR10 TFAP2C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.77 CCR10 GJB1 TFAP2C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.77 TFAP2C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.77 TFAP2C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.77 CCR10 GJB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.77 GJB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 CCR10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.77 GJB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.77 GJB1 TFAP2C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.77 CCR10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.77 GJB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.77 GJB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.77 TFAP2C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.77 TFAP2C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.77 TFAP2C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.77 CCR10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.77 TFAP2C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 CCR10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 TFAP2C

MGI Mouse Phenotypes related to Testicular Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 CCR10 CCR3 CD79A CD9 FOS GJB1
2 hematopoietic system MP:0005397 9.85 ACKR4 CCR10 CCR3 CD79A CD9 FOS
3 immune system MP:0005387 9.65 ACKR2 ACKR4 CCR10 CCR3 CD79A CD9
4 normal MP:0002873 9.23 ACKR4 CCR10 CD79A FOS POU5F1 STAT1

Drugs & Therapeutics for Testicular Leukemia

Drugs for Testicular Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 3 58-05-9 143 6006
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Thioguanine Approved Phase 3 154-42-7 2723601
4
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
6
Daunorubicin Approved Phase 3 20830-81-3 30323
7
Pegaspargase Approved, Investigational Phase 3 130167-69-0
8
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
9
Mercaptopurine Approved Phase 3 50-44-2 667490
10
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
11
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
12
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
13
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
14
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
15
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
16
Etoposide Approved Phase 3 33419-42-0 36462
17
Ichthammol Approved Phase 3 8029-68-3
18
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
19
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
20
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
21
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
22
Mesna Approved, Investigational Phase 3 3375-50-6 598
23
Busulfan Approved, Investigational Phase 3 55-98-1 2478
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
25
Tyrosine Approved, Investigational, Nutraceutical Phase 3 60-18-4 6057
26
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
27
Doxil Approved June 1999 Phase 3 31703
28
Cortisone Experimental Phase 3 53-06-5 222786
29
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
30 Antibiotics, Antitubercular Phase 3
31 Nucleic Acid Synthesis Inhibitors Phase 3
32 Antimitotic Agents Phase 3
33 Immunosuppressive Agents Phase 3
34 Autonomic Agents Phase 3
35 Antirheumatic Agents Phase 3
36 Dermatologic Agents Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39 Antimetabolites Phase 3
40 glucocorticoids Phase 3
41 Anti-Bacterial Agents Phase 3
42 Topoisomerase Inhibitors Phase 3
43 Vitamin B Complex Phase 3
44 Gastrointestinal Agents Phase 3
45 Antiviral Agents Phase 3
46 Antineoplastic Agents, Alkylating Phase 3
47 Antiemetics Phase 3
48 BB 1101 Phase 3
49 Folic Acid Antagonists Phase 3
50 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
2 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy Not yet recruiting NCT03959085 Phase 3 Cyclophosphamide;Cytarabine;Daunorubicin;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin;Doxorubicin Hydrochloride;Leucovorin;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisolone;Thioguanine;Vincristine;Vincristine Sulfate
3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Suspended NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
4 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna

Search NIH Clinical Center for Testicular Leukemia

Genetic Tests for Testicular Leukemia

Anatomical Context for Testicular Leukemia

MalaCards organs/tissues related to Testicular Leukemia:

42
Monocytes, Bone Marrow, Ovary

Publications for Testicular Leukemia

Articles related to Testicular Leukemia:

(show all 19)
# Title Authors Year
1
Relapsed testicular leukemia: local insights in to a vanishing disease. ( 20448368 )
2010
2
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. ( 9528974 )
1998
3
Testicular leukemia relapse. Fine needle aspiration findings. ( 9568129 )
1998
4
Needle biopsy in the diagnosis of testicular leukemia in children. ( 2709505 )
1989
5
Occult testicular leukemia in a patient with acute monocytic leukemia. ( 3152942 )
1987
6
The enigma of testicular leukemia: a critical review. ( 3537653 )
1986
7
Management of children with isolated testicular leukemia. ( 6498764 )
1984
8
Incidence and detection of testicular leukemia in children. ( 6590152 )
1984
9
Treatment of murine testicular leukemia. ( 6722788 )
1984
10
The ultrasound diagnosis of testicular leukemia. ( 6400260 )
1983
11
Ultrasound diagnosis of testicular leukemia. ( 6571758 )
1983
12
Isolated testicular leukemia following bone marrow transplant for acute lymphocytic leukemia. The need for pretransplant testicular biopsies. ( 7046495 )
1982
13
Diagnosis of testicular leukemia. ( 7201513 )
1982
14
Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study. ( 6939470 )
1981
15
Proceedings of the tumor board of the Children's Hospital of Philadelphia. Testicular leukemia: incidence and management results. ( 6946280 )
1981
16
Clinical and occult testicular leukemia in long-term survivors of acute lymphoblastic leukemia. ( 6928464 )
1980
17
Radiotherapy (2500 rad) for testicular leukemia: local control and subsequent clinical events: a Southwest Oncology Group study. ( 6994868 )
1980
18
Testicular leukemia. ( 5413403 )
1970
19
Testicular leukemia. ( 5461011 )
1970

Variations for Testicular Leukemia

Expression for Testicular Leukemia

Search GEO for disease gene expression data for Testicular Leukemia.

Pathways for Testicular Leukemia

Pathways related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 CCR3 FOS STAT1
2
Show member pathways
10.99 ACKR2 ACKR4 CCR10 CCR3

GO Terms for Testicular Leukemia

Cellular components related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 ACKR2 ACKR4 CCR10 CCR3 CD79A CD9

Biological processes related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 ACKR2 ACKR4 CCR10 CCR3
2 chemotaxis GO:0006935 9.62 ACKR2 ACKR4 CCR10 CCR3
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.56 ACKR2 ACKR4 CCR10 CCR3
4 calcium-mediated signaling GO:0019722 9.46 ACKR2 ACKR4 CCR10 CCR3
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.37 FOS WT1
6 cell chemotaxis GO:0060326 9.26 ACKR2 ACKR4 CCR10 CCR3
7 chemokine-mediated signaling pathway GO:0070098 8.92 ACKR2 ACKR4 CCR10 CCR3

Molecular functions related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.77 FOS POU5F1 STAT1 TFAP2C WT1
2 chemokine binding GO:0019956 9.56 ACKR2 ACKR4 CCR10 CCR3
3 C-C chemokine binding GO:0019957 9.46 ACKR2 ACKR4 CCR10 CCR3
4 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.32 FOS STAT1
5 C-C chemokine receptor activity GO:0016493 9.26 ACKR2 ACKR4 CCR10 CCR3
6 chemokine receptor activity GO:0004950 8.92 ACKR2 ACKR4 CCR10 CCR3

Sources for Testicular Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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