MCID: TST003
MIFTS: 32

Testicular Leukemia

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Leukemia

MalaCards integrated aliases for Testicular Leukemia:

Name: Testicular Leukemia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12286
NCIt 50 C9277
UMLS 73 C1336711

Summaries for Testicular Leukemia

MalaCards based summary : Testicular Leukemia is related to leukemia and venous hemangioma. An important gene associated with Testicular Leukemia is MAGEA4 (MAGE Family Member A4), and among its related pathways/superpathways are Kaposi's sarcoma-associated herpesvirus infection and Regulation of Telomerase. The drugs Cyclophosphamide and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and monocytes.

Related Diseases for Testicular Leukemia

Diseases related to Testicular Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia 10.2
2 venous hemangioma 10.0 POU5F1 WT1
3 extragonadal seminoma 9.6 POU5F1 TFAP2C
4 leukemia, acute monocytic 9.6
5 leukemia, acute lymphoblastic 9.6
6 acute lymphocytic leukemia 9.6
7 lymphoblastic leukemia 9.6
8 childhood leukemia 9.6
9 monocytic leukemia 9.6
10 human immunodeficiency virus type 1 9.3 CCR3 CD9 STAT1

Graphical network of the top 20 diseases related to Testicular Leukemia:



Diseases related to Testicular Leukemia

Symptoms & Phenotypes for Testicular Leukemia

Drugs & Therapeutics for Testicular Leukemia

Drugs for Testicular Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
2
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
3
Daunorubicin Approved Phase 3 20830-81-3 30323
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
5
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
6
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
7
Pegaspargase Approved, Investigational Phase 3 130167-69-0
8
Thioguanine Approved Phase 3 154-42-7 2723601
9
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
10
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
11
Cortisone acetate Approved, Investigational Phase 3 1950-04-4, 50-04-4 5745
12
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
13
Etoposide Approved Phase 3 33419-42-0 36462
14
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
15
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
16
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
18
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
19
Busulfan Approved, Investigational Phase 3 55-98-1 2478
20
Mesna Approved, Investigational Phase 3 3375-50-6 598
21
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
24
Doxil Approved June 1999 Phase 3 31703
25
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
26 6-Mercaptopurine Phase 3
27 Alkylating Agents Phase 3
28 Anti-Bacterial Agents Phase 3
29 Antibiotics, Antitubercular Phase 3
30 Antiemetics Phase 3
31 Anti-Infective Agents Phase 3
32 Anti-Inflammatory Agents Phase 3
33 Antimetabolites Phase 3
34 Antimetabolites, Antineoplastic Phase 3
35 Antimitotic Agents Phase 3
36 Antineoplastic Agents, Alkylating Phase 3
37 Antineoplastic Agents, Hormonal Phase 3
38 Antineoplastic Agents, Phytogenic Phase 3
39 Antirheumatic Agents Phase 3
40 Antiviral Agents Phase 3
41
asparaginase Phase 3
42 Autonomic Agents Phase 3
43 BB 1101 Phase 3
44 Dermatologic Agents Phase 3
45 Dexamethasone acetate Phase 3 1177-87-3
46 Folic Acid Antagonists Phase 3
47 Gastrointestinal Agents Phase 3
48 glucocorticoids Phase 3
49 Hormone Antagonists Phase 3
50 Hormones Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
2 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Recruiting NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
3 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna

Search NIH Clinical Center for Testicular Leukemia

Genetic Tests for Testicular Leukemia

Anatomical Context for Testicular Leukemia

MalaCards organs/tissues related to Testicular Leukemia:

41
Bone, Bone Marrow, Monocytes

Publications for Testicular Leukemia

Articles related to Testicular Leukemia:

(show all 19)
# Title Authors Year
1
Relapsed testicular leukemia: local insights in to a vanishing disease. ( 20448368 )
2010
2
Testicular leukemia relapse. Fine needle aspiration findings. ( 9568129 )
1998
3
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. ( 9528974 )
1998
4
Needle biopsy in the diagnosis of testicular leukemia in children. ( 2709505 )
1989
5
Occult testicular leukemia in a patient with acute monocytic leukemia. ( 3152942 )
1987
6
The enigma of testicular leukemia: a critical review. ( 3537653 )
1986
7
Incidence and detection of testicular leukemia in children. ( 6590152 )
1984
8
Management of children with isolated testicular leukemia. ( 6498764 )
1984
9
Treatment of murine testicular leukemia. ( 6722788 )
1984
10
The ultrasound diagnosis of testicular leukemia. ( 6400260 )
1983
11
Ultrasound diagnosis of testicular leukemia. ( 6571758 )
1983
12
Diagnosis of testicular leukemia. ( 7201513 )
1982
13
Isolated testicular leukemia following bone marrow transplant for acute lymphocytic leukemia. The need for pretransplant testicular biopsies. ( 7046495 )
1982
14
Proceedings of the tumor board of the Children's Hospital of Philadelphia. Testicular leukemia: incidence and management results. ( 6946280 )
1981
15
Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study. ( 6939470 )
1981
16
Radiotherapy (2500 rad) for testicular leukemia: local control and subsequent clinical events: a Southwest Oncology Group study. ( 6994868 )
1980
17
Clinical and occult testicular leukemia in long-term survivors of acute lymphoblastic leukemia. ( 6928464 )
1980
18
Testicular leukemia. ( 5413403 )
1970
19
Testicular leukemia. ( 5461011 )
1970

Variations for Testicular Leukemia

Expression for Testicular Leukemia

Search GEO for disease gene expression data for Testicular Leukemia.

Pathways for Testicular Leukemia

Pathways related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.95 CCR3 FOS STAT1
2 11.14 FOS WT1
3
Show member pathways
11.01 CCR3 FOS STAT1
4 10.92 FOS STAT1
5 10.63 FOS STAT1

GO Terms for Testicular Leukemia

Biological processes related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.8 FOS POU5F1 PREB STAT1 TFAP2C WT1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 POU5F1 STAT1 TFAP2C WT1
3 response to cytokine GO:0034097 9.37 FOS STAT1
4 transcription by RNA polymerase II GO:0006366 9.26 FOS POU5F1 TFAP2C WT1
5 response to cAMP GO:0051591 9.16 FOS STAT1
6 positive regulation of transcription by RNA polymerase II GO:0045944 9.02 FOS POU5F1 STAT1 TFAP2C WT1

Molecular functions related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.8 FOS POU5F1 STAT1 TFAP2C WT1
2 DNA binding GO:0003677 9.63 FOS POU5F1 PREB STAT1 TFAP2C WT1
3 sequence-specific DNA binding GO:0043565 9.62 FOS POU5F1 STAT1 WT1
4 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.54 FOS TFAP2C WT1
5 core promoter binding GO:0001047 9.43 STAT1 TFAP2C
6 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.26 FOS STAT1
7 DNA binding transcription factor activity GO:0003700 9.02 FOS POU5F1 STAT1 TFAP2C WT1
8 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 8.96 FOS STAT1

Sources for Testicular Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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