MCID: TST003
MIFTS: 34

Testicular Leukemia

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Leukemia

MalaCards integrated aliases for Testicular Leukemia:

Name: Testicular Leukemia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12286
NCIt 50 C9277
UMLS 73 C1336711

Summaries for Testicular Leukemia

MalaCards based summary : Testicular Leukemia is related to leukemia and orofacial granulomatosis. An important gene associated with Testicular Leukemia is MAGEA4 (MAGE Family Member A4), and among its related pathways/superpathways are Kit receptor signaling pathway and FGF signaling pathway. The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include bone, b lymphoblasts and bone marrow, and related phenotypes are cellular and hematopoietic system

Related Diseases for Testicular Leukemia

Diseases related to Testicular Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 leukemia 10.3
2 orofacial granulomatosis 10.0 CCR3 CD79A
3 venous hemangioma 10.0 POU5F1 WT1
4 pediatric lymphoma 10.0 CD79A CD9
5 mixed germ cell-sex cord neoplasm 10.0 POU5F1 WT1
6 extragonadal seminoma 9.9 POU5F1 TFAP2C
7 dysgerminoma of ovary 9.9 CD79A WT1
8 lymphocytic leukemia 9.9
9 leukemia, acute monocytic 9.7
10 leukemia, acute lymphoblastic 9.7
11 acute lymphocytic leukemia 9.7
12 childhood leukemia 9.7
13 monocytic leukemia 9.7

Graphical network of the top 20 diseases related to Testicular Leukemia:



Diseases related to Testicular Leukemia

Symptoms & Phenotypes for Testicular Leukemia

MGI Mouse Phenotypes related to Testicular Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CCR3 CD79A CD9 FOS GJB1 POU5F1
2 hematopoietic system MP:0005397 9.76 CCR3 CD79A CD9 FOS GJB1 POU5F1
3 liver/biliary system MP:0005370 9.35 CD79A GJB1 POU5F1 STAT1 WT1
4 normal MP:0002873 9.1 CD79A FOS POU5F1 STAT1 TFAP2C WT1

Drugs & Therapeutics for Testicular Leukemia

Drugs for Testicular Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
4
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
5
leucovorin Approved Phase 3 58-05-9 6006 143
6
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
8
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
9
Thioguanine Approved Phase 3 154-42-7 2723601
10
Pegaspargase Approved, Investigational Phase 3 130167-69-0
11
Daunorubicin Approved Phase 3 20830-81-3 30323
12
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
13
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
14
Etoposide Approved Phase 3 33419-42-0 36462
15
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
16
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
17
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
18
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
19
Cortisone acetate Approved, Investigational Phase 3 1950-04-4, 50-04-4 5745
20
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
21
Busulfan Approved, Investigational Phase 3 55-98-1 2478
22
Mesna Approved, Investigational Phase 3 3375-50-6 598
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
24
Doxil Approved June 1999 Phase 3 31703
25
Cortisone Experimental Phase 3 53-06-5 222786
26 Immunologic Factors Phase 3
27 Vitamin B9 Phase 3
28 Immunosuppressive Agents Phase 3
29 Antimetabolites Phase 3
30
asparaginase Phase 3
31 Antiviral Agents Phase 3
32 Antirheumatic Agents Phase 3
33 Anti-Inflammatory Agents Phase 3
34 Folic Acid Antagonists Phase 3
35 Antiemetics Phase 3
36 Gastrointestinal Agents Phase 3
37 Vitamin B Complex Phase 3
38 Autonomic Agents Phase 3
39 Dermatologic Agents Phase 3
40 Antineoplastic Agents, Phytogenic Phase 3
41 Peripheral Nervous System Agents Phase 3
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
43 Alkylating Agents Phase 3
44 Hormones Phase 3
45 Antineoplastic Agents, Alkylating Phase 3
46 6-Mercaptopurine Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 BB 1101 Phase 3
49 Anti-Bacterial Agents Phase 3
50 Hormone Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
2 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Recruiting NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
3 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna

Search NIH Clinical Center for Testicular Leukemia

Genetic Tests for Testicular Leukemia

Anatomical Context for Testicular Leukemia

MalaCards organs/tissues related to Testicular Leukemia:

41
Bone, B Lymphoblasts, Bone Marrow, Monocytes, Ovary

Publications for Testicular Leukemia

Articles related to Testicular Leukemia:

(show all 19)
# Title Authors Year
1
Relapsed testicular leukemia: local insights in to a vanishing disease. ( 20448368 )
2010
2
Testicular leukemia relapse. Fine needle aspiration findings. ( 9568129 )
1998
3
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. ( 9528974 )
1998
4
Needle biopsy in the diagnosis of testicular leukemia in children. ( 2709505 )
1989
5
Occult testicular leukemia in a patient with acute monocytic leukemia. ( 3152942 )
1987
6
The enigma of testicular leukemia: a critical review. ( 3537653 )
1986
7
Incidence and detection of testicular leukemia in children. ( 6590152 )
1984
8
Management of children with isolated testicular leukemia. ( 6498764 )
1984
9
Treatment of murine testicular leukemia. ( 6722788 )
1984
10
The ultrasound diagnosis of testicular leukemia. ( 6400260 )
1983
11
Ultrasound diagnosis of testicular leukemia. ( 6571758 )
1983
12
Diagnosis of testicular leukemia. ( 7201513 )
1982
13
Isolated testicular leukemia following bone marrow transplant for acute lymphocytic leukemia. The need for pretransplant testicular biopsies. ( 7046495 )
1982
14
Proceedings of the tumor board of the Children's Hospital of Philadelphia. Testicular leukemia: incidence and management results. ( 6946280 )
1981
15
Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study. ( 6939470 )
1981
16
Radiotherapy (2500 rad) for testicular leukemia: local control and subsequent clinical events: a Southwest Oncology Group study. ( 6994868 )
1980
17
Clinical and occult testicular leukemia in long-term survivors of acute lymphoblastic leukemia. ( 6928464 )
1980
18
Testicular leukemia. ( 5413403 )
1970
19
Testicular leukemia. ( 5461011 )
1970

Variations for Testicular Leukemia

Expression for Testicular Leukemia

Search GEO for disease gene expression data for Testicular Leukemia.

Pathways for Testicular Leukemia

Pathways related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.01 CCR3 FOS STAT1
2 10.63 FOS STAT1

GO Terms for Testicular Leukemia

Biological processes related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.46 FOS POU5F1 TFAP2C WT1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.35 FOS POU5F1 STAT1 TFAP2C WT1
3 response to cAMP GO:0051591 9.26 FOS STAT1
4 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 FOS WT1

Molecular functions related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.46 FOS POU5F1 STAT1 WT1
2 DNA-binding transcription factor activity GO:0003700 9.02 FOS POU5F1 STAT1 TFAP2C WT1
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 FOS STAT1

Sources for Testicular Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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