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MCID: TST003
MIFTS: 27

Testicular Leukemia

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Testicular Leukemia

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MalaCards integrated aliases for Testicular Leukemia:

Name: Testicular Leukemia 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12286
NCIt 49 C9277
UMLS 71 C1336711
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Summaries for Testicular Leukemia

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MalaCards based summary : Testicular Leukemia is related to childhood acute lymphocytic leukemia and leukemia. An important gene associated with Testicular Leukemia is VWA8-AS1 (VWA8 Antisense RNA 1 (Head To Head)). The drugs Idarubicin and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include b lymphoblasts, testis and bone marrow.

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Related Diseases for Testicular Leukemia

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Diseases related to Testicular Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 childhood acute lymphocytic leukemia 29.4 ETV6 ASPG ABL1
2 leukemia 10.4
3 b-lymphoblastic leukemia/lymphoma with hypodiploidy 10.1 ETV6 ABL1
4 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.1 ETV6 ABL1
5 b-lymphoblastic leukemia/lymphoma with iamp21 10.1 ETV6 ABL1
6 leukemia, acute lymphoblastic 10.1
7 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.1 ETV6 ABL1
8 mental retardation, autosomal dominant 33 10.1 ETV6 ABL1
9 myelodysplastic/myeloproliferative neoplasm 10.0 ETV6 ABL1
10 atypical chronic myeloid leukemia 10.0 ETV6 ABL1
11 acute monoblastic leukemia 9.9
12 chronic eosinophilic leukemia 9.9 ETV6 ABL1
13 adult acute lymphocytic leukemia 9.9 ETV6 ASPG ABL1
14 erythroleukemia, familial 9.8
15 leukemia, acute monocytic 9.8
16 leukemia, chronic lymphocytic 9.8
17 acute promyelocytic leukemia 9.8
18 acute leukemia 9.8
19 childhood leukemia 9.8
20 monocytic leukemia 9.8
21 plasma cell leukemia 9.8
22 acute myeloblastic leukemia without maturation 9.8
23 splenomegaly 9.8
24 acute monoblastic/monocytic leukemia 9.8
25 leukemia, acute lymphoblastic 3 9.8 ETV6 ABL1

Graphical network of the top 20 diseases related to Testicular Leukemia:



Diseases related to Testicular Leukemia
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Symptoms & Phenotypes for Testicular Leukemia

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Drugs & Therapeutics for Testicular Leukemia

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Drugs for Testicular Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Idarubicin Approved Phase 3 58957-92-9 42890
2
Lenograstim Approved, Investigational Phase 3 135968-09-1
3
Ifosfamide Approved Phase 3 3778-73-2 3690
4
Sargramostim Approved, Investigational Phase 2, Phase 3 83869-56-1, 123774-72-1
5
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
6
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
7
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
8
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
9 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
10
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
11
inotuzumab ozogamicin Approved, Investigational Phase 3 635715-01-4
12
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
13
Pegaspargase Approved, Investigational Phase 3 130167-69-0
14
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
15
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
16
Daunorubicin Approved Phase 3 20830-81-3 30323
17
Mercaptopurine Approved Phase 3 50-44-2 667490
18
Thioguanine Approved Phase 3 154-42-7 2723601
19
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
20
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
21
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
22
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
23
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
24
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
25
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
26
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
27
Ichthammol Approved Phase 3 8029-68-3
28
Etoposide Approved Phase 3 33419-42-0 36462
29
Mesna Approved, Investigational Phase 3 3375-50-6 598
30
leucovorin Approved Phase 3 58-05-9 6006 143
31
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
32
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
33
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
34
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
35
Busulfan Approved, Investigational Phase 3 55-98-1 2478
36
Aspartic acid Approved, Nutraceutical Phase 3 56-84-8 5960
37
Asparagine Approved, Investigational, Nutraceutical Phase 2, Phase 3 70-47-3 6267
38
Tyrosine Approved, Investigational, Nutraceutical Phase 3 60-18-4 6057
39
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
40
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
41
Cortisone Experimental Phase 3 53-06-5 222786
42 N-Methylaspartate Phase 3
43
Isophosphamide mustard Phase 3 0
44 Imatinib Mesylate Phase 3 220127-57-1 123596
45 Adjuvants, Immunologic Phase 2, Phase 3
46 Methylprednisolone Acetate Phase 3
47 Neuroprotective Agents Phase 3
48 Antibiotics, Antitubercular Phase 3
49 Gastrointestinal Agents Phase 3
50 Hormones Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Patients With Acute Lymphoblastic Leukemia With Unfavorable Features: A Phase III Group-wide Study Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
2 A Children's Oncology Group Pilot Study for the Treatment of Very High Risk Acute Lymphoblastic Leukemia in Children and Adolescents (Imatinib (STI571, GLEEVEC) NSC#716051) Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
3 Intensified Tyrosine Kinase Inhibitor Therapy (Dasatinib NSC# 732517) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (ALL) Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
4 Escalating Dose Intravenous Methotrexate Without Leucovorin Rescue Versus Oral Methotrexate and Single Versus Double Delayed Intensification for Children With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
5 A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy Recruiting NCT03959085 Phase 3 Cyclophosphamide;Cytarabine;Daunorubicin;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin;Doxorubicin Hydrochloride;Leucovorin;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisolone;Thioguanine;Vincristine;Vincristine Sulfate
6 A Phase III Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia (B-ALL) Including a Stratum Evaluating Dasatinib (NSC#732517) in Patients With Ph-Like Tyrosine Kinase Inhibitor (TKI) Sensitive Mutations Active, not recruiting NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
7 Randomized Trial of Busulfan or Total Body Irradiation Conditioning Regimens for Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
8 Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children Recruiting NCT02339350 Phase 2 high dose methotrexate;Intrathecal triple chemotherapy

Search NIH Clinical Center for Testicular Leukemia

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Genetic Tests for Testicular Leukemia

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Anatomical Context for Testicular Leukemia

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MalaCards organs/tissues related to Testicular Leukemia:

40
B Lymphoblasts, Testis, Bone Marrow, Bone, Testes, Monocytes, T Cells
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Publications for Testicular Leukemia

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Articles related to Testicular Leukemia:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Relative safety of various spermatogenic stem cell purification methods for application in spermatogenic stem cell transplantation. 61
31842987 2019
2
Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization. 61
30138085 2018
3
Relapsed testicular leukemia: local insights in to a vanishing disease. 61
20448368 2010
4
Effect of childhood acute lymphoblastic leukemia therapy on spermatogonia populations and future fertility. 61
19318447 2009
5
Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation. 61
15973454 2005
6
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. 61
9528974 1998
7
Testicular leukemia relapse. Fine needle aspiration findings. 61
9568129 1998
8
Treatment of isolated testicular recurrence of acute lymphoblastic leukemia without radiotherapy. Report from the Dutch Late Effects Study Group. 61
9179075 1997
9
Overt testicular disease at diagnosis is associated with high risk features and a poor prognosis in patients with childhood acute lymphoblastic leukemia. 61
8941016 1996
10
[Testicular biopsy at the stopping of the treatment in acute lymphoblastic leukemia: value of the immunohistochemical detection of residual blasts]. 61
8952791 1996
11
Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. 61
7863887 1995
12
Testicular lymphoblastic leukemia/lymphoma. 61
8528297 1995
13
Assessment of testicular biopsy after cessation of maintenance chemotherapy in childhood acute lymphoblastic leukemia: a report from the Children's Cancer and Leukemia Study Group. 61
7948963 1994
14
Treatment of CNS relapse in children with acute lymphoblastic leukemia: A Pediatric Oncology Group study. 61
8426204 1993
15
Elective testicular biopsy at the end of maintenance treatment for acute lymphoblastic leukemia. A prospective study. 61
1477063 1992
16
Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study. 61
1602793 1992
17
Treatment of occult or late overt testicular relapse in children with acute lymphoblastic leukemia: a Pediatric Oncology Group study. 61
1548525 1992
18
Prognostic significance of testicular relapse in boys with acute lymphoblastic leukemia. 61
1528308 1992
19
Extramedullary relapse in childhood leukemia. 61
1792914 1991
20
Fine-needle aspiration biopsy (FNAB) diagnosis of testicular involvement in acute lymphoblastic leukemia in children. 61
1954829 1991
21
Open-wedge testicular biopsy in childhood acute lymphoblastic leukemia after two years of maintenance therapy: diagnostic accuracy and influence on outcome--a report from Children's Cancer Study Group. 61
2407298 1990
22
Scrotal ultrasonography as adjunct to testis biopsy in leukemia. 61
2180174 1990
23
The prognostic value of testicular biopsy in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group. 61
2295911 1990
24
Needle biopsy in the diagnosis of testicular leukemia in children. 61
2709505 1989
25
[Radiotherapy of testicular infiltration in childhood leukemia]. 61
2612336 1989
26
Three versus five years of maintenance therapy are equivalent in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group. 61
2645385 1989
27
Isolated testicular leukemic relapse. Response to radiation therapy. 61
3477044 1987
28
Occult testicular leukemia in a patient with acute monocytic leukemia. 61
3152942 1987
29
Noninvasive testicular screening in childhood leukemia. 61
3531553 1986
30
The enigma of testicular leukemia: a critical review. 61
3537653 1986
31
Leydig cell function in boys following treatment for testicular relapse of acute lymphoblastic leukemia. 61
3928829 1985
32
Management of children with isolated testicular leukemia. 61
6498764 1984
33
Isolated testicular relapse in acute lymphocytic leukemia of childhood: categories and influence on survival. 61
6589364 1984
34
Treatment of murine testicular leukemia. 61
6722788 1984
35
Incidence and detection of testicular leukemia in children. 61
6590152 1984
36
Correlation of gonadal function with histology of testicular biopsies at treatment discontinuation in childhood acute leukemia. 61
6422220 1984
37
Leukemic infiltration of the testes in acute nonlymphocytic leukemia. 61
6727774 1984
38
Recurrent testicular infiltrates following radiation therapy for lymphoid malignancy. 61
6593576 1984
39
Acute leukemia: diagnosis and management of testicular involvement. 61
6575491 1983
40
Ultrasound diagnosis of testicular leukemia. 61
6571758 1983
41
The ultrasound diagnosis of testicular leukemia. 61
6400260 1983
42
[Extramedullary leukemia]. 61
7167959 1982
43
Diagnosis of testicular leukemia. 61
7201513 1982
44
Gonadal morphology in patients receiving chemotherapy for leukemia. Evidence for reproductive potential and against a testicular tumor sanctuary. 61
7081273 1982
45
Isolated testicular leukemia following bone marrow transplant for acute lymphocytic leukemia. The need for pretransplant testicular biopsies. 61
7046495 1982
46
Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study. 61
6939470 1981
47
Proceedings of the tumor board of the Children's Hospital of Philadelphia. Testicular leukemia: incidence and management results. 61
6946280 1981
48
Relapse rate after cessation of therapy in childhood leukemia. A follow-up report on 277 cases from the five Nordic countries. 61
7234388 1980
49
Radiotherapy (2500 rad) for testicular leukemia: local control and subsequent clinical events: a Southwest Oncology Group study. 61
6994868 1980
50
Testicular relapse in childhood acute lymphoblastic leukemia: association with pretreatment patient characteristics and treatment. A report for Childrens Cancer Study Group. 61
6989482 1980
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Variations for Testicular Leukemia

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Expression for Testicular Leukemia

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Search GEO for disease gene expression data for Testicular Leukemia.
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Pathways for Testicular Leukemia

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GO Terms for Testicular Leukemia

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Molecular functions related to Testicular Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleic acid binding GO:0003676 9.02 ZNF549 ZNF343 ZNF260 RNASE11 R3HCC1
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Sources for Testicular Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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