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MCID: TST001
MIFTS: 32

Testicular Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Testicular Leydig Cell Tumor

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MalaCards integrated aliases for Testicular Leydig Cell Tumor:

Name: Testicular Leydig Cell Tumor 12 15 17
Interstitial Cell Neoplasm of Testis 72
Testicular Leydig Cell Neoplasm 12
Leydig Cell Tumor of Testis 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4756
NCIt 50 C6356
UMLS 72 C0863027 C2062507
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Summaries for Testicular Leydig Cell Tumor

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MalaCards based summary : Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to leydig cell tumor and adrenal cortical adenoma. An important gene associated with Testicular Leydig Cell Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. Affiliated tissues include testis, and related phenotypes are Reduced mammosphere formation and growth/size/body region

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Related Diseases for Testicular Leydig Cell Tumor

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Diseases in the Testicular Leydig Cell Tumor family:

Malignant Testicular Leydig Cell Tumor

Diseases related to Testicular Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 31.0 STAR INSL3 CYP21A2 CYP17A1 CYP11A1
2 adrenal cortical adenoma 30.0 POMC CYP21A2 CYP17A1 CYP11A1
3 adrenal adenoma 29.8 POMC CYP21A2 CYP17A1 CYP11A1
4 lipoid congenital adrenal hyperplasia 29.1 STAR POMC HSD3B1 CYP21A2 CYP17A1 CYP11A1
5 adrenocortical carcinoma, hereditary 29.1 STAR POMC GNAS CYP21A2 CYP17A1 CYP11A1
6 malignant testicular leydig cell tumor 12.6
7 luteoma 10.5 STAR CYP21A2
8 infant gynecomastia 10.4
9 gynecomastia 10.4
10 epithelioid trophoblastic tumor 10.3 KRT18 CGB3
11 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.3 POMC CYP21A2
12 46 xy gonadal dysgenesis 10.3 STAR CYP11A1 CGB3
13 transsexualism 10.3 CYP21A2 CYP17A1
14 tuberculous epididymitis 10.3 POMC CGB3
15 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.3 CYP21A2 CYP17A1 CYP11A1
16 azoospermia 10.2
17 infertility 10.2
18 adenoma 10.2
19 precocious puberty 10.2
20 hypospadias 10.2 INSL3 CYP17A1 CYP11A1
21 adrenal rest tumor 10.2 POMC HSD3B1 CYP21A2
22 acute adrenal insufficiency 10.1 POMC CYP21A2 CYP11A1
23 adrenal cortical hypofunction 10.1 POMC CYP21A2 CYP11A1
24 cytochrome p450 oxidoreductase deficiency 10.1 POMC CYP21A2 CYP17A1
25 polykaryocytosis inducer 10.0
26 cryptorchidism, unilateral or bilateral 10.0
27 adrenal cortical carcinoma 10.0
28 malignant leydig cell tumor 10.0
29 sexual disorder 10.0
30 male infertility 10.0
31 estrogen excess 10.0
32 testicular cancer 10.0
33 adrenal cortical adenocarcinoma 10.0
34 posttransplant acute limbic encephalitis 10.0
35 rare tumor 10.0
36 polycystic ovary syndrome 10.0 STAR CYP21A2 CYP17A1 CYP11A1
37 hyperandrogenism 10.0 POMC CYP21A2 CYP17A1
38 cornea cancer 9.9 NF2 CDK4
39 hypoadrenocorticism, familial 9.9 STAR POMC CYP21A2 CYP11A1
40 paraphimosis 9.9 SLC5A4 SLC5A2
41 cortisone reductase deficiency 9.8 POMC CYP21A2 CYP17A1 CYP11A1
42 glossopharyngeal neuralgia 9.8 POMC NR5A2
43 balanoposthitis 9.7 SLC5A4 SLC5A2
44 fanconi-like syndrome 9.6 SLC5A4 SLC5A2
45 nervous system cancer 9.6 PTCH1 NF2 CDK4
46 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 9.6 STAR POMC CYP21A2 CYP17A1 CYP11A1
47 conn's syndrome 9.6 POMC GNAS CYP21A2 CYP17A1 CYP11A1
48 adrenal carcinoma 9.6 STAR POMC CYP21A2 CYP17A1 CYP11A1
49 pancreas disease 9.5 SLC5A4 SLC5A2 POMC
50 glucose metabolism disease 9.5 SLC5A4 SLC5A2 POMC

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:



Diseases related to Testicular Leydig Cell Tumor
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Symptoms & Phenotypes for Testicular Leydig Cell Tumor

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GenomeRNAi Phenotypes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CDK4 CYP21A2 GNAS KRT18 NR5A2 POMC

MGI Mouse Phenotypes related to Testicular Leydig Cell Tumor:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 CDK4 CYP11A1 CYP17A1 GNAS KRT18 NF2
2 behavior/neurological MP:0005386 10.18 CDK4 CYP11A1 CYP17A1 GNAS INSL3 NF2
3 homeostasis/metabolism MP:0005376 10.18 CDK4 CYP11A1 CYP17A1 GNAS NF2 NR5A2
4 endocrine/exocrine gland MP:0005379 10.16 CDK4 CYP11A1 GNAS INSL3 NF2 NR5A2
5 mortality/aging MP:0010768 10.1 CDK4 CYP11A1 CYP17A1 GNAS KRT18 NF2
6 adipose tissue MP:0005375 9.97 CYP17A1 GNAS POMC RICTOR SLC5A1 SLC5A2
7 liver/biliary system MP:0005370 9.97 CDK4 CYP11A1 GNAS KRT18 NF2 NR5A2
8 renal/urinary system MP:0005367 9.76 CDK4 GNAS NF2 POMC PTCH1 RICTOR
9 neoplasm MP:0002006 9.73 CDK4 GNAS NF2 POMC PTCH1 RICTOR
10 reproductive system MP:0005389 9.61 CDK4 CYP11A1 CYP17A1 INSL3 NF2 NR5A2
11 skeleton MP:0005390 9.23 CYP17A1 GNAS INSL3 NF2 PTCH1 RICTOR
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Drugs & Therapeutics for Testicular Leydig Cell Tumor

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Search Clinical Trials , NIH Clinical Center for Testicular Leydig Cell Tumor

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Genetic Tests for Testicular Leydig Cell Tumor

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Anatomical Context for Testicular Leydig Cell Tumor

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MalaCards organs/tissues related to Testicular Leydig Cell Tumor:

41
Testis
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Publications for Testicular Leydig Cell Tumor

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Articles related to Testicular Leydig Cell Tumor:

(show all 41)
# Title Authors PMID Year
1
Management of testicular Leydig cell tumor: A case report. 38
29924022 2018
2
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. 38
29330226 2018
3
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. 38
27833751 2016
4
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. 38
26525589 2015
5
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. 38
24855728 2014
6
Testicular Leydig cell tumor diagnosed on fine needle aspiration. 38
20737589 2010
7
F-18 FDG PET/CT imaging of a Leydig cell tumor. 38
20173460 2010
8
Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. 38
27307872 2010
9
[Testicular Leydig cell tumor presenting as male infertility: a case report]. 38
20048565 2009
10
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. 38
18041368 2007
11
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 38
17437857 2007
12
Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 38
17070249 2006
13
[An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy]. 38
16671273 2006
14
Testicular leydig cell tumor presenting as primary infertility. 38
17018455 2002
15
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. 38
11545298 2001
16
Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. 38
11536438 2001
17
Spontaneous neoplastic lesions in aged Sprague-Dawley rats. 38
11381627 2001
18
[Precocious puberty caused by a testicular Leydig cell tumor]. 38
11232155 2001
19
[The Leydig-cell testicular tumor. A case report with magnetic resonance images]. 38
9887568 1998
20
Localization of the steroidogenic acute regulatory protein in human tissues. 38
9398748 1997
21
Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture. 38
8732455 1996
22
[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. 38
7702009 1995
23
Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. 38
8147220 1994
24
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. 38
8105109 1993
25
Benign Leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of Leser-Trélat. 38
8396689 1993
26
Ultrasound and CT of a calcified testicular Leydig cell tumor. 38
1522284 1992
27
Transformed murine leydig-cells in serum-free culture - useful model for analyses of steroid hormone-induced cell-growth and cell morphology (review). 38
21584561 1992
28
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. 38
1387343 1992
29
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. 38
1751389 1991
30
[Adrenal adenoma with bilateral testicular Leydig cell tumor: a case report]. 38
1957732 1991
31
Low expression of 3 beta-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. 38
1848566 1991
32
[Testicular leydig cell tumor in a child: a case report]. 38
2694835 1989
33
[A case of intra-scrotal and extra-testicular Leydig cell tumor]. 38
2696424 1989
34
[Bilateral testicular Leydig cell tumor. Procedure to follow]. 38
3045206 1988
35
Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. 38
3818898 1987
36
Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. 38
3896459 1985
37
[Testicular Leydig cell tumor. A case]. 38
6234579 1984
38
Ultrastructure of feminizing testicular Leydig cell tumors. 38
7157496 1982
39
[Feminizing testicular Leydig cell tumor. Case contribution to the differential diagnosis of gynecomastia]. 38
7268342 1981
40
Effects of a feminizing testicular Leydig cell tumour on nontumorous testicular tissue: an ultrastructual study. 38
844220 1977
41
[A case of testicular Leydig cell tumor with gynecomastia]. 38
13138998 1953
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Variations for Testicular Leydig Cell Tumor

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Expression for Testicular Leydig Cell Tumor

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Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.
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Pathways for Testicular Leydig Cell Tumor

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Pathways related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.57 STAR POMC HSD3B1 GNAS CYP21A2 CYP17A1
2
Glucose / Energy Metabolism 4
12.26 STAR SLC5A2 SLC5A1 CYP17A1 CYP11A1
3
G alpha (s) signalling events 66
11.82 POMC INSL3 GNAS
4
NRF2 pathway 1
11.79 SLC5A4 SLC5A2 SLC5A1
5
Hexose transport 66
Show member pathways
 11.58 SLC5A4 SLC5A2 SLC5A1
6
Steroid hormone biosynthesis 37
Show member pathways
 11.44 HSD3B1 CYP21A2 CYP17A1 CYP11A1
7
Corticotropin-releasing hormone signaling pathway 1
11.4 STAR POMC HSD3B1 GNAS CYP21A2 CYP11A1
8
Ovarian steroidogenesis 37
11.24 STAR HSD3B1 GNAS CYP17A1 CYP11A1
9
Metabolism of steroid hormones 66
Show member pathways
 11.04 STAR POMC HSD3B1 CYP21A2 CYP17A1 CYP11A1
10
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.76 CYP21A2 CYP17A1
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GO Terms for Testicular Leydig Cell Tumor

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Cellular components related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.02 PTCH1 NF2 KRT18 GNAS CDK4

Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.81 STAR PTCH1 GNAS CDK4
2 sodium ion transport GO:0006814 9.73 SLC5A4 SLC5A2 SLC5A1
3 regulation of cell proliferation GO:0042127 9.71 PTCH1 NR5A2 NF2 CDK4
4 steroid metabolic process GO:0008202 9.7 CYP21A2 CYP17A1 CYP11A1
5 embryo development ending in birth or egg hatching GO:0009792 9.57 RICTOR NR5A2
6 response to lead ion GO:0010288 9.55 STAR CDK4
7 response to corticosterone GO:0051412 9.54 STAR HSD3B1
8 estrogen biosynthetic process GO:0006703 9.49 STAR HSD3B1
9 negative regulation of multicellular organism growth GO:0040015 9.48 PTCH1 GNAS
10 C21-steroid hormone biosynthetic process GO:0006700 9.46 STAR CYP11A1
11 androgen biosynthetic process GO:0006702 9.43 HSD3B1 CYP17A1
12 C21-steroid hormone metabolic process GO:0008207 9.37 HSD3B1 CYP11A1
13 steroid biosynthetic process GO:0006694 9.35 STAR HSD3B1 CYP21A2 CYP17A1 CYP11A1
14 glucose transmembrane transport GO:1904659 9.33 SLC5A4 SLC5A2 SLC5A1
15 mineralocorticoid biosynthetic process GO:0006705 9.32 HSD3B1 CYP21A2
16 sterol metabolic process GO:0016125 9.26 CYP21A2 CYP11A1
17 glucocorticoid biosynthetic process GO:0006704 8.92 HSD3B1 CYP21A2 CYP17A1 CYP11A1

Molecular functions related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.58 CYP21A2 CYP17A1 CYP11A1
2 heme binding GO:0020037 9.54 CYP21A2 CYP17A1 CYP11A1
3 transmembrane transporter activity GO:0022857 9.5 SLC5A4 SLC5A2 SLC5A1
4 hormone activity GO:0005179 9.43 POMC INSL3 CGB3
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.33 CYP21A2 CYP17A1 CYP11A1
6 G protein-coupled receptor binding GO:0001664 9.13 POMC INSL3 GNAS
7 glucose:sodium symporter activity GO:0005412 8.8 SLC5A4 SLC5A2 SLC5A1
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Sources for Testicular Leydig Cell Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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