MCID: TST001
MIFTS: 35

Testicular Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Leydig Cell Tumor

MalaCards integrated aliases for Testicular Leydig Cell Tumor:

Name: Testicular Leydig Cell Tumor 12 15 17
Interstitial Cell Neoplasm of Testis 74
Testicular Leydig Cell Neoplasm 12
Leydig Cell Tumor of Testis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4756
NCIt 51 C6356

Summaries for Testicular Leydig Cell Tumor

MalaCards based summary : Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to leydig cell tumor and malignant testicular leydig cell tumor. An important gene associated with Testicular Leydig Cell Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism and Aldosterone synthesis and secretion. The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and pituitary.

Related Diseases for Testicular Leydig Cell Tumor

Diseases in the Testicular Leydig Cell Tumor family:

Malignant Testicular Leydig Cell Tumor

Diseases related to Testicular Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 30.7 CYP11A1 CYP17A1 CYP21A2 STAR
2 malignant testicular leydig cell tumor 12.5
3 luteoma 10.2 CYP21A2 STAR
4 transsexualism 10.2 CYP17A1 CYP21A2
5 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 CYP21A2 POMC
6 tuberculous epididymitis 10.1 CGB3 POMC
7 cholesterol ester storage disease 10.1 CYP11A1 STAR
8 antley-bixler syndrome 10.1 CYP17A1 CYP21A2
9 mycetoma 10.1 CYP17A1 HSD3B1
10 familial glucocorticoid deficiency 10.1 POMC STAR
11 infertility 10.0
12 pituitary-dependent cushing's disease 10.0 CYP21A2 POMC
13 46 xy gonadal dysgenesis 10.0 CGB3 CYP11A1 STAR
14 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.0 CYP11A1 CYP17A1 CYP21A2
15 mammographic density 10.0 CYP17A1 ESR1
16 adrenal rest tumor 10.0 CYP21A2 HSD3B1 POMC
17 postmenopausal atrophic vaginitis 10.0 ESR1 POMC
18 acute adrenal insufficiency 10.0 CYP11A1 CYP21A2 POMC
19 adrenal cortical hypofunction 9.9 CYP11A1 CYP21A2 POMC
20 cytochrome p450 oxidoreductase deficiency 9.9 CYP17A1 CYP21A2 POMC
21 juvenile nasopharyngeal angiofibroma 9.9 CYP11A1 ESR1
22 adrenal gland disease 9.9 CYP11A1 POMC
23 hyperandrogenism 9.9 CYP17A1 CYP21A2 POMC
24 glossopharyngeal neuralgia 9.8 NR5A2 POMC
25 ovarian disease 9.8 CYP11A1 ESR1 STAR
26 polycystic ovary syndrome 9.8 CYP11A1 CYP17A1 CYP21A2 STAR
27 hypoadrenocorticism, familial 9.7 CYP11A1 CYP21A2 POMC STAR
28 gynecomastia 9.7 ESR1 POMC
29 adrenal cortical adenoma 9.7 CYP11A1 CYP17A1 CYP21A2 POMC
30 adrenal adenoma 9.7 CYP11A1 CYP17A1 CYP21A2 POMC
31 conn's syndrome 9.7 CYP11A1 CYP17A1 CYP21A2 POMC
32 primary pigmented nodular adrenocortical disease 9.6 ESR1 POMC
33 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 9.5 CYP11A1 CYP17A1 CYP21A2 POMC STAR
34 adrenal carcinoma 9.5 CYP11A1 CYP17A1 CYP21A2 POMC STAR
35 adrenocortical carcinoma, hereditary 9.5 CYP11A1 CYP17A1 CYP21A2 POMC STAR
36 cortisone reductase deficiency 9.4 CYP11A1 CYP17A1 CYP21A2 HSD17B6 POMC
37 steroid inherited metabolic disorder 9.3 CYP11A1 CYP17A1 CYP21A2 HSD3B1 POMC STAR
38 lipoid congenital adrenal hyperplasia 9.3 CYP11A1 CYP17A1 CYP21A2 HSD3B1 POMC STAR

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:



Diseases related to Testicular Leydig Cell Tumor

Symptoms & Phenotypes for Testicular Leydig Cell Tumor

Drugs & Therapeutics for Testicular Leydig Cell Tumor

Drugs for Testicular Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Antibodies Phase 2
4 Antineoplastic Agents, Immunological Phase 2
5 Antibodies, Monoclonal Phase 2
6 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cabozantinib in Combination With Nivolumab and Ipilimumab in Rare Genitourinary Tumors Recruiting NCT03866382 Phase 2 Cabozantinib;Cabozantinib S-malate

Search NIH Clinical Center for Testicular Leydig Cell Tumor

Genetic Tests for Testicular Leydig Cell Tumor

Anatomical Context for Testicular Leydig Cell Tumor

MalaCards organs/tissues related to Testicular Leydig Cell Tumor:

42
Testis, Ovary, Pituitary, Adrenal Gland

Publications for Testicular Leydig Cell Tumor

Articles related to Testicular Leydig Cell Tumor:

(show all 18)
# Title Authors Year
1
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. ( 29330226 )
2018
2
Management of testicular Leydig cell tumor: A case report. ( 29924022 )
2018
3
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ( 26525589 )
2015
4
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. ( 24855728 )
2014
5
Testicular Leydig cell tumor diagnosed on fine needle aspiration. ( 20737589 )
2010
6
Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. ( 27307872 )
2010
7
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. ( 17437857 )
2007
8
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. ( 18041368 )
2007
9
Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. ( 17070249 )
2006
10
Testicular leydig cell tumor presenting as primary infertility. ( 17018455 )
2002
11
Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. ( 11536438 )
2001
12
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. ( 11545298 )
2001
13
Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. ( 8147220 )
1994
14
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. ( 1387343 )
1992
15
Ultrasound and CT of a calcified testicular Leydig cell tumor. ( 1522284 )
1992
16
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. ( 1751389 )
1991
17
Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. ( 3818898 )
1987
18
Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. ( 3896459 )
1985

Variations for Testicular Leydig Cell Tumor

Expression for Testicular Leydig Cell Tumor

Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.

Pathways for Testicular Leydig Cell Tumor

Pathways related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CYP11A1 CYP17A1 CYP21A2 HSD17B6 HSD3B1 POMC
2
Show member pathways
12.66 CYP11A1 CYP17A1 CYP21A2 HSD3B1 POMC STAR
3 12.16 CYP11A1 CYP17A1 HSD17B6 STAR
4 11.52 CYP11A1 CYP21A2 HSD3B1 POMC STAR
5 11.25 CYP11A1 CYP17A1 HSD3B1 STAR
6
Show member pathways
11.17 CYP17A1 HSD3B1
7
Show member pathways
11.17 CYP11A1 CYP17A1 CYP21A2 HSD17B6 HSD3B1
8
Show member pathways
11.04 CYP11A1 CYP17A1 CYP21A2 HSD3B1 POMC STAR
9
Show member pathways
10.75 CYP17A1 CYP21A2

GO Terms for Testicular Leydig Cell Tumor

Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 CYP11A1 CYP17A1 CYP21A2 HSD17B6 HSD3B1
2 steroid metabolic process GO:0008202 9.56 CYP11A1 CYP17A1 CYP21A2 HSD17B6
3 response to estrogen GO:0043627 9.55 ESR1 STAR
4 steroid hormone mediated signaling pathway GO:0043401 9.54 ESR1 NR5A2
5 hormone-mediated signaling pathway GO:0009755 9.52 CGB3 NR5A2
6 intracellular receptor signaling pathway GO:0030522 9.51 ESR1 NR5A2
7 response to corticosterone GO:0051412 9.49 HSD3B1 STAR
8 estrogen biosynthetic process GO:0006703 9.48 HSD3B1 STAR
9 C21-steroid hormone biosynthetic process GO:0006700 9.46 CYP11A1 STAR
10 C21-steroid hormone metabolic process GO:0008207 9.4 CYP11A1 HSD3B1
11 mineralocorticoid biosynthetic process GO:0006705 9.37 CYP21A2 HSD3B1
12 steroid biosynthetic process GO:0006694 9.35 CYP11A1 CYP17A1 CYP21A2 HSD3B1 STAR
13 androgen biosynthetic process GO:0006702 9.33 CYP17A1 HSD17B6 HSD3B1
14 sterol metabolic process GO:0016125 9.32 CYP11A1 CYP21A2
15 glucocorticoid biosynthetic process GO:0006704 8.92 CYP11A1 CYP17A1 CYP21A2 HSD3B1

Molecular functions related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.5 CYP11A1 CYP17A1 CYP21A2
2 lipid binding GO:0008289 9.46 CYP21A2 ESR1 NR5A2 STAR
3 steroid hormone receptor activity GO:0003707 9.43 ESR1 NR5A2
4 iron ion binding GO:0005506 9.43 CYP11A1 CYP17A1 CYP21A2
5 nuclear receptor activity GO:0004879 9.4 ESR1 NR5A2
6 steroid binding GO:0005496 9.37 CYP21A2 ESR1
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP11A1 CYP17A1 CYP21A2
8 oxidoreductase activity GO:0016491 9.02 CYP11A1 CYP17A1 CYP21A2 HSD17B6 HSD3B1

Sources for Testicular Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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