MCID: TST001
MIFTS: 26

Testicular Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Leydig Cell Tumor

MalaCards integrated aliases for Testicular Leydig Cell Tumor:

Name: Testicular Leydig Cell Tumor 12 15 17
Interstitial Cell Neoplasm of Testis 71
Testicular Leydig Cell Neoplasm 12
Leydig Cell Tumor of Testis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4756
NCIt 49 C6356
UMLS 71 C0863027 C2062507

Summaries for Testicular Leydig Cell Tumor

MalaCards based summary : Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to leydig cell tumor and lipoid congenital adrenal hyperplasia. An important gene associated with Testicular Leydig Cell Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Hexose transport and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include testis, cortex and adrenal gland.

Related Diseases for Testicular Leydig Cell Tumor

Diseases in the Testicular Leydig Cell Tumor family:

Malignant Testicular Leydig Cell Tumor

Diseases related to Testicular Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 31.5 INSL3 CYP21A2
2 lipoid congenital adrenal hyperplasia 30.0 HSD3B1 CYP21A2
3 malignant testicular leydig cell tumor 12.6
4 infant gynecomastia 10.5
5 gynecomastia 10.5
6 adrenal rest tumor 10.2 INSL3 CYP21A2
7 adrenal cortical adenoma 10.2
8 azoospermia 10.2
9 infertility 10.2
10 adenoma 10.2
11 precocious puberty 10.2
12 germinoma 10.1 CYP21A2 CGB3
13 steroid inherited metabolic disorder 10.1 HSD3B1 CYP21A2
14 acth-independent cushing syndrome 10.1 PDE11A CYP21A2
15 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.1 NNT CYP21A2
16 cortisone reductase deficiency 10.1 NNT CYP21A2
17 testicular sex cord-stromal neoplasm 10.0 PDE11A INSL3
18 polykaryocytosis inducer 10.0
19 adrenocortical carcinoma, hereditary 10.0
20 cryptorchidism, unilateral or bilateral 10.0
21 adrenal cortical carcinoma 10.0
22 malignant leydig cell tumor 10.0
23 sexual disorder 10.0
24 male infertility 10.0
25 estrogen excess 10.0
26 testicular cancer 10.0
27 adrenal cortical adenocarcinoma 10.0
28 adrenal adenoma 10.0
29 posttransplant acute limbic encephalitis 10.0
30 rare tumor 10.0
31 achalasia-addisonianism-alacrima syndrome 10.0 NNT CYP21A2
32 adrenal cortex disease 10.0 PDE11A CYP21A2
33 adrenal gland disease 10.0 PDE11A CYP21A2
34 46 xy gonadal dysgenesis 9.9 CYP21A2 CGB3
35 testicular disease 9.9 PDE11A INSL3
36 sex development disorder 9.9 INSL3 HSD3B1 CYP21A2
37 hyperandrogenism 9.8 INSL3 CYP21A2
38 turner syndrome 9.7 CYP21A2 CGB3
39 pancreatic colloid cystadenoma 9.7 SLC5A4 SLC5A2
40 silent myocardial infarction 9.7 SLC5A4 SLC5A2
41 vulvitis 9.7 SLC5A4 SLC5A2
42 balanoposthitis 9.7 SLC5A4 SLC5A2
43 balanitis 9.7 SLC5A4 SLC5A2
44 osmotic diarrhea 9.7 SLC5A4 SLC5A2
45 vulvovaginitis 9.7 SLC5A4 SLC5A2
46 nasopharyngitis 9.6 SLC5A4 SLC5A2
47 renal glucosuria 9.6 SLC5A4 SLC5A2
48 pyelitis 9.6 SLC5A4 SLC5A2
49 penile disease 9.6 SLC5A4 SLC5A2
50 diabetes mellitus, ketosis-prone 9.6 SLC5A4 SLC5A2

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:



Diseases related to Testicular Leydig Cell Tumor

Symptoms & Phenotypes for Testicular Leydig Cell Tumor

Drugs & Therapeutics for Testicular Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Leydig Cell Tumor

Genetic Tests for Testicular Leydig Cell Tumor

Anatomical Context for Testicular Leydig Cell Tumor

MalaCards organs/tissues related to Testicular Leydig Cell Tumor:

40
Testis, Cortex, Adrenal Gland, Adrenal Cortex

Publications for Testicular Leydig Cell Tumor

Articles related to Testicular Leydig Cell Tumor:

(show all 41)
# Title Authors PMID Year
1
Management of testicular Leydig cell tumor: A case report. 61
29924022 2018
2
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. 61
29330226 2018
3
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. 61
27833751 2016
4
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. 61
26525589 2015
5
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. 61
24855728 2014
6
Testicular Leydig cell tumor diagnosed on fine needle aspiration. 61
20737589 2010
7
F-18 FDG PET/CT imaging of a Leydig cell tumor. 61
20173460 2010
8
Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. 61
27307872 2010
9
[Testicular Leydig cell tumor presenting as male infertility: a case report]. 61
20048565 2009
10
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. 61
18041368 2007
11
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 61
17437857 2007
12
Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 61
17070249 2006
13
[An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy]. 61
16671273 2006
14
Testicular leydig cell tumor presenting as primary infertility. 61
17018455 2002
15
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. 61
11545298 2001
16
Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. 61
11536438 2001
17
Spontaneous neoplastic lesions in aged Sprague-Dawley rats. 61
11381627 2001
18
[Precocious puberty caused by a testicular Leydig cell tumor]. 61
11232155 2001
19
[The Leydig-cell testicular tumor. A case report with magnetic resonance images]. 61
9887568 1998
20
Localization of the steroidogenic acute regulatory protein in human tissues. 61
9398748 1997
21
Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture. 61
8732455 1996
22
[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. 61
7702009 1995
23
Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. 61
8147220 1994
24
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. 61
8105109 1993
25
Benign Leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of Leser-Trélat. 61
8396689 1993
26
Ultrasound and CT of a calcified testicular Leydig cell tumor. 61
1522284 1992
27
Transformed murine leydig-cells in serum-free culture - useful model for analyses of steroid hormone-induced cell-growth and cell morphology (review). 61
21584561 1992
28
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. 61
1387343 1992
29
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. 61
1751389 1991
30
[Adrenal adenoma with bilateral testicular Leydig cell tumor: a case report]. 61
1957732 1991
31
Low expression of 3 beta-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. 61
1848566 1991
32
[Testicular leydig cell tumor in a child: a case report]. 61
2694835 1989
33
[A case of intra-scrotal and extra-testicular Leydig cell tumor]. 61
2696424 1989
34
[Bilateral testicular Leydig cell tumor. Procedure to follow]. 61
3045206 1988
35
Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. 61
3818898 1987
36
Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. 61
3896459 1985
37
[Testicular Leydig cell tumor. A case]. 61
6234579 1984
38
Ultrastructure of feminizing testicular Leydig cell tumors. 61
7157496 1982
39
[Feminizing testicular Leydig cell tumor. Case contribution to the differential diagnosis of gynecomastia]. 61
7268342 1981
40
Effects of a feminizing testicular Leydig cell tumour on nontumorous testicular tissue: an ultrastructual study. 61
844220 1977
41
[A case of testicular Leydig cell tumor with gynecomastia]. 61
13138998 1953

Variations for Testicular Leydig Cell Tumor

Expression for Testicular Leydig Cell Tumor

Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.

Pathways for Testicular Leydig Cell Tumor

GO Terms for Testicular Leydig Cell Tumor

Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid biosynthetic process GO:0006694 9.26 HSD3B1 CYP21A2
2 glucose transmembrane transport GO:1904659 9.16 SLC5A4 SLC5A2
3 glucocorticoid biosynthetic process GO:0006704 8.96 HSD3B1 CYP21A2
4 mineralocorticoid biosynthetic process GO:0006705 8.62 HSD3B1 CYP21A2

Molecular functions related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 INSL3 CGB3
2 glucose:sodium symporter activity GO:0005412 8.62 SLC5A4 SLC5A2

Sources for Testicular Leydig Cell Tumor

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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19 FMA
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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44 MESH via Orphanet
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48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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