Testicular Leydig Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to lipoid congenital adrenal hyperplasia and leydig cell tumor. An important gene associated with Testicular Leydig Cell Tumor is PABIR3 (PABIR Family Member 3). The drugs Nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include testis.

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Related Diseases for Testicular Leydig Cell Tumor

Diseases related to Testicular Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)

#	Related Disease	Score	Top Affiliating Genes
1	lipoid congenital adrenal hyperplasia	29.4	INSL3 HSD3B1
2	leydig cell tumor	10.8
3	testicular cancer	10.5
4	gynecomastia	10.5
5	adrenal cortical adenoma	10.2
6	spermatogenic failure	10.2
7	infertility	10.2
8	adrenal adenoma	10.2
9	adenoma	10.2
10	precocious puberty	10.2
11	polykaryocytosis inducer	10.1
12	adrenocortical carcinoma, hereditary	10.1
13	mucolipidosis ii alpha/beta	10.1
14	adrenal cortical carcinoma	10.1
15	male infertility	10.1
16	estrogen excess	10.1
17	hydrocele	10.1
18	posttransplant acute limbic encephalitis	10.1
19	rare tumor	10.1
20	testicular disease	9.9	PDE11A INSL3
21	leydig cell hypoplasia	9.8	INSL3 HSD3B1
22	pseudohermaphroditism	9.7	INSL3 HSD3B1
23	acth-independent macronodular adrenal hyperplasia	9.7	PDE11A HSD3B1
24	adrenal cortex disease	9.7	PDE11A HSD3B1
25	adrenal gland disease	9.7	PDE11A HSD3B1
26	46,xy sex reversal	9.7	INSL3 HSD3B1
27	adrenal carcinoma	9.6	PDE11A HSD3B1
28	testicular sex cord-stromal neoplasm	8.0	SOWAHA RNF157 RIPPLY2 RANBP17 PDE11A PABIR3

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:

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Symptoms & Phenotypes for Testicular Leydig Cell Tumor

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Drugs & Therapeutics for Testicular Leydig Cell Tumor

Drugs for Testicular Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Nivolumab

Approved

Phase 2

946414-94-4

2

Ipilimumab

Approved

Phase 2

477202-00-9

3

Antineoplastic Agents, Immunological

Phase 2

4

Antibodies, Monoclonal

Phase 2

5

Antibodies

Phase 2

6

Immunoglobulins

Phase 2

7

Immune Checkpoint Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC)	Recruiting	NCT03866382	Phase 2	Cabozantinib S-malate

Search NIH Clinical Center for Testicular Leydig Cell Tumor

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Genetic Tests for Testicular Leydig Cell Tumor

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Anatomical Context for Testicular Leydig Cell Tumor

Organs/tissues related to Testicular Leydig Cell Tumor:

MalaCards : Testis

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Publications for Testicular Leydig Cell Tumor

Articles related to Testicular Leydig Cell Tumor:

(show all 46)

#	Title	Authors	PMID	Year
1	Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features. ⁶²	Rizzo NM...Acosta AM	34103665	2021
2	Testicular leydig cell tumor revealed by hydrocele. ⁶²	Ben Kridis W...Khanfir A	33318945	2021
3	Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice. ⁶²	Ponikwicka-Tyszko D...Rahman NA	33158280	2020
4	Leydig cell tumor of a testis with azoospermia: A case report and literature review. ⁶²	Kong Q...Liu Y	32899084	2020
5	An Excessive Testosterone Producing Testicular Leydig Cell Tumor as a Rare Cause of Secondary Acquired Erythrocytosis. ⁶²	Deruyver Y...Van Baelen A	32289359	2020
6	Management of testicular Leydig cell tumor: A case report. ⁶²	Zhu J...Li H	29924022	2018
7	Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. ⁶²	Chortis V...Arlt W	29330226	2018
8	Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. ⁶²	Prasivoravong J...Rigot JM	27833751	2016
9	Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ⁶²	Geminiani JJ...Brandes SB	26525589	2015
10	Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. ⁶²	Cost NG...Flaig TW	24855728	2014
11	Testicular Leydig cell tumor diagnosed on fine needle aspiration. ⁶²	Handa U...Punia RS	20737589	2010
12	F-18 FDG PET/CT imaging of a Leydig cell tumor. ⁶²	Lee G...Lee WA	20173460	2010
13	Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. ⁶²	Obembe OO...Patel MD	27307872	2010
14	[Testicular Leydig cell tumor presenting as male infertility: a case report]. ⁶²	Shiraishi Y...Ogawa O	20048565	2009
15	Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. ⁶²	Tavolini IM...Dal Moro F	18041368	2007
16	Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. ⁶²	Giannarini G...Morelli G	17437857	2007
17	Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. ⁶²	Carmignani L...Pizzocaro G	17070249	2006
18	[An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy]. ⁶²	Bertola G...Di Nuovo F	16671273	2006
19	Testicular leydig cell tumor presenting as primary infertility. ⁶²	Markou A...Franks S	17018455	2002
20	Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. ⁶²	Jain M...Dhar S	11536438	2001
21	Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. ⁶²	Herath CB...Taya K	11545298	2001
22	Spontaneous neoplastic lesions in aged Sprague-Dawley rats. ⁶²	Nakazawa M...Sumi N	11381627	2001
23	[Precocious puberty caused by a testicular Leydig cell tumor]. ⁶²	Sagodi L...Solyom E	11232155	2001
24	[The Leydig-cell testicular tumor. A case report with magnetic resonance images]. ⁶²	Tamayo Ruiz JC...Viano J	9887568	1998
25	Localization of the steroidogenic acute regulatory protein in human tissues. ⁶²	Pollack SE...Strauss JF	9398748	1997
26	Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture. ⁶²	Sasano H...Nagura H	8732455	1996
27	[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. ⁶²	Gotoh A...Umezu K	7702009	1995
28	Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. ⁶²	Gupta SK...Das DK	8147220	1994
29	Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. ⁶²	Kirsch AJ...Glassberg KI	8105109	1993
30	Benign Leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of Leser-Trélat. ⁶²	Martin RW...Tyring SK	8396689	1993
31	Ultrasound and CT of a calcified testicular Leydig cell tumor. ⁶²	Laks MP...Ozoktay SZ	1522284	1992
32	Transformed murine leydig-cells in serum-free culture - useful model for analyses of steroid hormone-induced cell-growth and cell morphology (review). ⁶²	Sato B...Nishizawa Y	21584561	1992
33	Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. ⁶²	Rao MS...Reddy JK	1387343	1992
34	Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. ⁶²	Namiki M...Sonoda T	1751389	1991
35	[Adrenal adenoma with bilateral testicular Leydig cell tumor: a case report]. ⁶²	Kobayashi Y...Kiychara H	1957732	1991
36	Low expression of 3 beta-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. ⁶²	Voutilainen R...Miettinen PJ	1848566	1991
37	[Testicular leydig cell tumor in a child: a case report]. ⁶²	Nishino A...Nonomura A	2694835	1989
38	[A case of intra-scrotal and extra-testicular Leydig cell tumor]. ⁶²	Fiatte P...Thibault P	2696424	1989
39	[Bilateral testicular Leydig cell tumor. Procedure to follow]. ⁶²	De Jong Z...Mansat A	3045206	1988
40	Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. ⁶²	Mineur P...De Hertogh R	3818898	1987
41	Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. ⁶²	Czernobilsky H...Ziegler R	3896459	1985
42	[Testicular Leydig cell tumor. A case]. ⁶²	Gancel A...Schrub JC	6234579	1984
43	Ultrastructure of feminizing testicular Leydig cell tumors. ⁶²	Sohval AR...Katz N	7157496	1982
44	[Feminizing testicular Leydig cell tumor. Case contribution to the differential diagnosis of gynecomastia]. ⁶²	Schonle S...Froesch ER	7268342	1981
45	Effects of a feminizing testicular Leydig cell tumour on nontumorous testicular tissue: an ultrastructual study. ⁶²	Sohval AR...Gabrilove JL	844220	1977
46	[A case of testicular Leydig cell tumor with gynecomastia]. ⁶²	GUINET P...MORNEX R	13138998	1953

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Genes for Testicular Leydig Cell Tumor

Genes related to Testicular Leydig Cell Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PABIR3	PABIR Family Member 3	Protein Coding	6.66	DISEASES inferred ¹⁴
2	SOWAHA	Sosondowah Ankyrin Repeat Domain Family Member A	Protein Coding	6.2	DISEASES inferred ¹⁴
3	RNF157	Ring Finger Protein 157	Protein Coding	5.93	DISEASES inferred ¹⁴
4	INSL3	Insulin Like 3	Protein Coding	5.93	DISEASES inferred ¹⁴
5	CRACD	Capping Protein Inhibiting Regulator Of Actin Dynamics	Protein Coding	5.89	DISEASES inferred ¹⁴
6	RIPPLY2	Ripply Transcriptional Repressor 2	Protein Coding	5.83	DISEASES inferred ¹⁴
7	RANBP17	RAN Binding Protein 17	Protein Coding	5.33	DISEASES inferred ¹⁴
8	DNAH1	Dynein Axonemal Heavy Chain 1	Protein Coding	5.07	DISEASES inferred ¹⁴
9	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	5.03	DISEASES inferred ¹⁴
10	PDE11A	Phosphodiesterase 11A	Protein Coding	4.98	DISEASES inferred ¹⁴

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Variations for Testicular Leydig Cell Tumor

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Expression for Testicular Leydig Cell Tumor

Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.

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Pathways for Testicular Leydig Cell Tumor

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GO Terms for Testicular Leydig Cell Tumor

Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cAMP-mediated signaling	GO:0043951	8.92	RNF157 PDE11A

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Sources for Testicular Leydig Cell Tumor

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⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

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⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: TST001 MIFTS: 23	Testicular Leydig Cell Tumor Categories: Cancer diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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