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MCID: TST001
MIFTS: 25

Testicular Leydig Cell Tumor

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Testicular Leydig Cell Tumor

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MalaCards integrated aliases for Testicular Leydig Cell Tumor:

Name: Testicular Leydig Cell Tumor 12 15 17
Interstitial Cell Neoplasm of Testis 71
Testicular Leydig Cell Neoplasm 12
Leydig Cell Tumor of Testis 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4756
NCIt 49 C39942 C6356
SNOMED-CT 67 67871000119105
UMLS 71 C0863027 C1515288 C2062507
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Summaries for Testicular Leydig Cell Tumor

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MalaCards based summary : Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to leydig cell tumor and adrenal cortical carcinoma. An important gene associated with Testicular Leydig Cell Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Metabolism of steroid hormones. Affiliated tissues include testis.

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Related Diseases for Testicular Leydig Cell Tumor

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Diseases related to Testicular Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 30.7 INSL3 GNAS CYP21A2
2 adrenal cortical carcinoma 30.3 PDE11A CYP21A2
3 precocious puberty 30.1 GNAS CYP21A2
4 lipoid congenital adrenal hyperplasia 30.0 HSD3B1 CYP21A2
5 adrenal adenoma 29.7 GNAS CYP21A2
6 infant gynecomastia 10.5
7 gynecomastia 10.5
8 adrenal rest tumor 10.3 INSL3 CYP21A2
9 persistent mullerian duct syndrome 10.2 INSL3 CYP21A2
10 germinoma 10.2 CYP21A2 CGB3
11 adrenal cortical adenoma 10.2
12 azoospermia 10.2
13 infertility 10.2
14 adenoma 10.2
15 steroid inherited metabolic disorder 10.2 HSD3B1 CYP21A2
16 46,xy sex reversal 2 10.1 HSD3B1 CYP21A2
17 adrenal cortex disease 10.1 PDE11A CYP21A2
18 polykaryocytosis inducer 10.0
19 adrenocortical carcinoma, hereditary 10.0
20 cryptorchidism, unilateral or bilateral 10.0
21 sexual disorder 10.0
22 male infertility 10.0
23 estrogen excess 10.0
24 testicular cancer 10.0
25 adrenal cortical adenocarcinoma 10.0
26 hydrocele 10.0
27 posttransplant acute limbic encephalitis 10.0
28 rare tumor 10.0
29 pseudohermaphroditism 9.9 INSL3 HSD3B1 CYP21A2
30 pancreatic colloid cystadenoma 9.9 SLC5A4 SLC5A2
31 disorders of sexual development 9.9 INSL3 HSD3B1 CYP21A2
32 vulvitis 9.9 SLC5A4 SLC5A2
33 balanoposthitis 9.9 SLC5A4 SLC5A2
34 splenic flexure cancer 9.9 SLC5A4 SLC5A2
35 balanitis 9.9 SLC5A4 SLC5A2
36 precocious puberty, male-limited 9.9 GNAS CYP21A2
37 vulvovaginitis 9.9 SLC5A4 SLC5A2
38 adrenal carcinoma 9.9 PDE11A HSD3B1 CYP21A2
39 nasopharyngitis 9.9 SLC5A4 SLC5A2
40 hyperandrogenism 9.9 INSL3 CYP21A2
41 pyelitis 9.9 SLC5A4 SLC5A2
42 renal glucosuria 9.9 SLC5A4 SLC5A2
43 diabetes mellitus, ketosis-prone 9.9 SLC5A4 SLC5A2
44 penile disease 9.8 SLC5A4 SLC5A2
45 prediabetes syndrome 9.8 SLC5A4 SLC5A2
46 sex cord-gonadal stromal tumor 9.8 PDE11A GNAS
47 acute cystitis 9.8 SLC5A4 SLC5A2
48 carney complex variant 9.7 PDE11A GNAS
49 primary pigmented nodular adrenocortical disease 9.7 PDE11A GNAS
50 fanconi syndrome 9.7 SLC5A4 SLC5A2

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:



Diseases related to Testicular Leydig Cell Tumor
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Symptoms & Phenotypes for Testicular Leydig Cell Tumor

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Drugs & Therapeutics for Testicular Leydig Cell Tumor

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Search Clinical Trials , NIH Clinical Center for Testicular Leydig Cell Tumor

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Genetic Tests for Testicular Leydig Cell Tumor

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Anatomical Context for Testicular Leydig Cell Tumor

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MalaCards organs/tissues related to Testicular Leydig Cell Tumor:

40
Testis
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Publications for Testicular Leydig Cell Tumor

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Articles related to Testicular Leydig Cell Tumor:

(show all 42)
# Title Authors PMID Year
1
An Excessive Testosterone Producing Testicular Leydig Cell Tumor as a Rare Cause of Secondary Acquired Erythrocytosis. 61
32289359 2020
2
Management of testicular Leydig cell tumor: A case report. 61
29924022 2018
3
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. 61
29330226 2018
4
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. 61
27833751 2016
5
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. 61
26525589 2015
6
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. 61
24855728 2014
7
Testicular Leydig cell tumor diagnosed on fine needle aspiration. 61
20737589 2010
8
F-18 FDG PET/CT imaging of a Leydig cell tumor. 61
20173460 2010
9
Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. 61
27307872 2010
10
[Testicular Leydig cell tumor presenting as male infertility: a case report]. 61
20048565 2009
11
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. 61
18041368 2007
12
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 61
17437857 2007
13
Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 61
17070249 2006
14
[An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy]. 61
16671273 2006
15
Testicular leydig cell tumor presenting as primary infertility. 61
17018455 2002
16
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. 61
11545298 2001
17
Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. 61
11536438 2001
18
Spontaneous neoplastic lesions in aged Sprague-Dawley rats. 61
11381627 2001
19
[Precocious puberty caused by a testicular Leydig cell tumor]. 61
11232155 2001
20
[The Leydig-cell testicular tumor. A case report with magnetic resonance images]. 61
9887568 1998
21
Localization of the steroidogenic acute regulatory protein in human tissues. 61
9398748 1997
22
Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture. 61
8732455 1996
23
[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. 61
7702009 1995
24
Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. 61
8147220 1994
25
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. 61
8105109 1993
26
Benign Leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of Leser-Trélat. 61
8396689 1993
27
Ultrasound and CT of a calcified testicular Leydig cell tumor. 61
1522284 1992
28
Transformed murine leydig-cells in serum-free culture - useful model for analyses of steroid hormone-induced cell-growth and cell morphology (review). 61
21584561 1992
29
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. 61
1387343 1992
30
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. 61
1751389 1991
31
[Adrenal adenoma with bilateral testicular Leydig cell tumor: a case report]. 61
1957732 1991
32
Low expression of 3 beta-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. 61
1848566 1991
33
[Testicular leydig cell tumor in a child: a case report]. 61
2694835 1989
34
[A case of intra-scrotal and extra-testicular Leydig cell tumor]. 61
2696424 1989
35
[Bilateral testicular Leydig cell tumor. Procedure to follow]. 61
3045206 1988
36
Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. 61
3818898 1987
37
Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. 61
3896459 1985
38
[Testicular Leydig cell tumor. A case]. 61
6234579 1984
39
Ultrastructure of feminizing testicular Leydig cell tumors. 61
7157496 1982
40
[Feminizing testicular Leydig cell tumor. Case contribution to the differential diagnosis of gynecomastia]. 61
7268342 1981
41
Effects of a feminizing testicular Leydig cell tumour on nontumorous testicular tissue: an ultrastructual study. 61
844220 1977
42
[A case of testicular Leydig cell tumor with gynecomastia]. 61
13138998 1953
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Variations for Testicular Leydig Cell Tumor

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Expression for Testicular Leydig Cell Tumor

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Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.
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Pathways for Testicular Leydig Cell Tumor

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Pathways related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 36
Show member pathways
 12.23 PDE11A HSD3B1 GNAS CYP21A2
2
Metabolism of steroid hormones 65
Show member pathways
 11.31 HSD3B1 CYP21A2
3
G alpha (s) signalling events 65
11.3 PDE11A INSL3 GNAS
4
Steroid hormone biosynthesis 36
Show member pathways
 11.15 HSD3B1 CYP21A2
5
Ovarian steroidogenesis 36
10.96 HSD3B1 GNAS
6
Corticotropin-releasing hormone signaling pathway 1
10.77 HSD3B1 GNAS CYP21A2
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GO Terms for Testicular Leydig Cell Tumor

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Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid biosynthetic process GO:0006694 9.26 HSD3B1 CYP21A2
2 glucose transmembrane transport GO:1904659 9.16 SLC5A4 SLC5A2
3 glucocorticoid biosynthetic process GO:0006704 8.96 HSD3B1 CYP21A2
4 mineralocorticoid biosynthetic process GO:0006705 8.62 HSD3B1 CYP21A2

Molecular functions related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 8.96 INSL3 GNAS
2 glucose:sodium symporter activity GO:0005412 8.62 SLC5A4 SLC5A2
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Sources for Testicular Leydig Cell Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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