MCID: TST001
MIFTS: 30

Testicular Leydig Cell Tumor

Categories: Cancer diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Testicular Leydig Cell Tumor

MalaCards integrated aliases for Testicular Leydig Cell Tumor:

Name: Testicular Leydig Cell Tumor 12 15
Interstitial Cell Neoplasm of Testis 73
Testicular Leydig Cell Neoplasm 12
Leydig Cell Tumor of Testis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4756
NCIt 50 C6356
SNOMED-CT 68 67871000119105

Summaries for Testicular Leydig Cell Tumor

MalaCards based summary : Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to leydig cell tumor and malignant testicular leydig cell tumor. An important gene associated with Testicular Leydig Cell Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. Affiliated tissues include testis.

Related Diseases for Testicular Leydig Cell Tumor

Diseases in the Testicular Leydig Cell Tumor family:

Malignant Testicular Leydig Cell Tumor

Diseases related to Testicular Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 30.5 CYP11A1 CYP17A1 CYP21A2 STAR
2 malignant testicular leydig cell tumor 12.3
3 luteoma 10.6 CYP21A2 STAR
4 transsexualism 10.5 CYP17A1 CYP21A2
5 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.5 CYP21A2 POMC
6 tuberculous epididymitis 10.5 CGB3 POMC
7 cholesterol ester storage disease 10.4 CYP11A1 STAR
8 antley-bixler syndrome 10.4 CYP17A1 CYP21A2
9 mycetoma 10.4 CYP17A1 HSD3B1
10 familial glucocorticoid deficiency 10.3 POMC STAR
11 46 xy gonadal dysgenesis 10.2 CGB3 CYP11A1 STAR
12 mammographic density 10.2 CYP17A1 ESR1
13 pituitary-dependent cushing's disease 10.1 CYP21A2 POMC
14 adrenal rest tumor 10.1 CYP21A2 HSD3B1 POMC
15 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.1 CYP11A1 CYP17A1 CYP21A2
16 acute adrenal insufficiency 10.1 CYP11A1 CYP21A2 POMC
17 polycystic ovary syndrome 10.1 CYP11A1 CYP17A1 CYP21A2
18 adrenal cortical hypofunction 10.1 CYP11A1 CYP21A2 POMC
19 cytochrome p450 oxidoreductase deficiency 10.1 CYP17A1 CYP21A2 POMC
20 juvenile nasopharyngeal angiofibroma 10.1 CYP11A1 ESR1
21 sex differentiation disease 10.0 CYP17A1 CYP21A2 POMC
22 secondary hypertrophic osteoarthropathy 10.0 POMC SMUG1
23 laryngeal tuberculosis 10.0 POMC SMUG1
24 hyperandrogenism 10.0 CYP17A1 CYP21A2 POMC
25 apparent mineralocorticoid excess 10.0 HSD17B6 POMC
26 pericardial tuberculosis 10.0 POMC SMUG1
27 gastric signet ring cell adenocarcinoma 10.0 ESR1 SMUG1
28 eccrine adenocarcinoma 10.0 ESR1 SMUG1
29 adrenal gland hyperfunction 9.9 CYP21A2 POMC
30 aging 9.9
31 infertility 9.9
32 ectopic cushing syndrome 9.9 POMC SMUG1
33 kleine-levin hibernation syndrome 9.8 POMC SMUG1
34 gynecomastia 9.8 ESR1 POMC
35 glossopharyngeal neuralgia 9.8 NR5A2 POMC
36 female reproductive system disease 9.7 CYP17A1 ESR1 POMC
37 hypoadrenocorticism, familial 9.7 CYP11A1 CYP21A2 POMC STAR
38 adrenal cortical adenoma 9.6 CYP11A1 CYP17A1 CYP21A2 POMC
39 adrenal adenoma 9.6 CYP11A1 CYP17A1 CYP21A2 POMC
40 conn's syndrome 9.6 CYP11A1 CYP17A1 CYP21A2 POMC
41 primary pigmented nodular adrenocortical disease 9.4 ESR1 POMC
42 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 9.2 CYP11A1 CYP17A1 CYP21A2 POMC STAR
43 adrenal carcinoma 9.2 CYP11A1 CYP17A1 CYP21A2 POMC STAR
44 adrenocortical carcinoma, hereditary 9.2 CYP11A1 CYP17A1 CYP21A2 POMC STAR
45 steroid inherited metabolic disorder 8.9 CYP11A1 CYP17A1 CYP21A2 HSD3B1 POMC STAR
46 lipoid congenital adrenal hyperplasia 8.9 CYP11A1 CYP17A1 CYP21A2 HSD3B1 POMC STAR

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:



Diseases related to Testicular Leydig Cell Tumor

Symptoms & Phenotypes for Testicular Leydig Cell Tumor

Drugs & Therapeutics for Testicular Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Leydig Cell Tumor

Genetic Tests for Testicular Leydig Cell Tumor

Anatomical Context for Testicular Leydig Cell Tumor

MalaCards organs/tissues related to Testicular Leydig Cell Tumor:

41
Testis

Publications for Testicular Leydig Cell Tumor

Articles related to Testicular Leydig Cell Tumor:

(show all 20)
# Title Authors Year
1
Management of testicular Leydig cell tumor: A case report. ( 29924022 )
2018
2
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. ( 29330226 )
2018
3
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ( 26525589 )
2015
4
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. ( 24855728 )
2014
5
The novel hormone INSL3 is expressed in human testicular Leydig cell tumors: a clinical and immunohistochemical study. ( 19110449 )
2011
6
Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. ( 27307872 )
2010
7
Testicular Leydig cell tumor diagnosed on fine needle aspiration. ( 20737589 )
2010
8
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. ( 18041368 )
2007
9
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. ( 17437857 )
2007
10
Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. ( 17070249 )
2006
11
Testicular leydig cell tumor presenting as primary infertility. ( 17018455 )
2002
12
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. ( 11545298 )
2001
13
Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. ( 11536438 )
2001
14
Overexpression of aromatase leads to development of testicular leydig cell tumors : an in vivo model for hormone-mediated TesticularCancer. ( 10623684 )
2000
15
Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. ( 8147220 )
1994
16
Ultrasound and CT of a calcified testicular Leydig cell tumor. ( 1522284 )
1992
17
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. ( 1387343 )
1992
18
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. ( 1751389 )
1991
19
Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. ( 3818898 )
1987
20
Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. ( 3896459 )
1985

Variations for Testicular Leydig Cell Tumor

Expression for Testicular Leydig Cell Tumor

Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.

Pathways for Testicular Leydig Cell Tumor

GO Terms for Testicular Leydig Cell Tumor

Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.8 CYP11A1 CYP17A1 CYP21A2 HSD17B6 HSD3B1
2 steroid metabolic process GO:0008202 9.56 CYP11A1 CYP17A1 CYP21A2 HSD17B6
3 intracellular receptor signaling pathway GO:0030522 9.51 ESR1 NR5A2
4 sterol metabolic process GO:0016125 9.5 CYP11A1 CYP17A1 CYP21A2
5 hormone-mediated signaling pathway GO:0009755 9.49 CGB3 NR5A2
6 peptide hormone processing GO:0016486 9.48 CGB3 POMC
7 estrogen biosynthetic process GO:0006703 9.46 HSD3B1 STAR
8 C21-steroid hormone biosynthetic process GO:0006700 9.43 CYP11A1 STAR
9 mineralocorticoid biosynthetic process GO:0006705 9.37 CYP21A2 HSD3B1
10 steroid biosynthetic process GO:0006694 9.35 CYP11A1 CYP17A1 CYP21A2 HSD3B1 STAR
11 androgen biosynthetic process GO:0006702 9.33 CYP17A1 HSD17B6 HSD3B1
12 glucocorticoid biosynthetic process GO:0006704 8.92 CYP11A1 CYP17A1 CYP21A2 HSD3B1

Molecular functions related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.5 CYP11A1 CYP17A1 CYP21A2
2 lipid binding GO:0008289 9.46 CYP21A2 ESR1 NR5A2 STAR
3 steroid hormone receptor activity GO:0003707 9.43 ESR1 NR5A2
4 heme binding GO:0020037 9.43 CYP11A1 CYP17A1 CYP21A2
5 nuclear receptor activity GO:0004879 9.4 ESR1 NR5A2
6 steroid binding GO:0005496 9.37 CYP21A2 ESR1
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP11A1 CYP17A1 CYP21A2
8 oxidoreductase activity GO:0016491 9.02 CYP11A1 CYP17A1 CYP21A2 HSD17B6 HSD3B1

Sources for Testicular Leydig Cell Tumor

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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