MCID: TST001
MIFTS: 23

Testicular Leydig Cell Tumor

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Testicular Leydig Cell Tumor

MalaCards integrated aliases for Testicular Leydig Cell Tumor:

Name: Testicular Leydig Cell Tumor 11 14 16
Interstitial Cell Neoplasm of Testis 71
Testicular Leydig Cell Neoplasm 11
Leydig Cell Tumor of Testis 71

Classifications:



External Ids:

Disease Ontology 11 DOID:4756
NCIt 49 C39942 C6356
SNOMED-CT 68 67871000119105
UMLS 71 C0863027 C1515288 C2062507

Summaries for Testicular Leydig Cell Tumor

MalaCards based summary: Testicular Leydig Cell Tumor, also known as interstitial cell neoplasm of testis, is related to lipoid congenital adrenal hyperplasia and leydig cell tumor. An important gene associated with Testicular Leydig Cell Tumor is PABIR3 (PABIR Family Member 3). The drugs Nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include testis.

Related Diseases for Testicular Leydig Cell Tumor

Graphical network of the top 20 diseases related to Testicular Leydig Cell Tumor:



Diseases related to Testicular Leydig Cell Tumor

Symptoms & Phenotypes for Testicular Leydig Cell Tumor

Drugs & Therapeutics for Testicular Leydig Cell Tumor

Drugs for Testicular Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Antineoplastic Agents, Immunological Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antibodies Phase 2
6 Immunoglobulins Phase 2
7 Immune Checkpoint Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC) Recruiting NCT03866382 Phase 2 Cabozantinib S-malate

Search NIH Clinical Center for Testicular Leydig Cell Tumor

Genetic Tests for Testicular Leydig Cell Tumor

Anatomical Context for Testicular Leydig Cell Tumor

Organs/tissues related to Testicular Leydig Cell Tumor:

MalaCards : Testis

Publications for Testicular Leydig Cell Tumor

Articles related to Testicular Leydig Cell Tumor:

(show all 46)
# Title Authors PMID Year
1
Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features. 62
34103665 2021
2
Testicular leydig cell tumor revealed by hydrocele. 62
33318945 2021
3
Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice. 62
33158280 2020
4
Leydig cell tumor of a testis with azoospermia: A case report and literature review. 62
32899084 2020
5
An Excessive Testosterone Producing Testicular Leydig Cell Tumor as a Rare Cause of Secondary Acquired Erythrocytosis. 62
32289359 2020
6
Management of testicular Leydig cell tumor: A case report. 62
29924022 2018
7
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. 62
29330226 2018
8
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. 62
27833751 2016
9
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. 62
26525589 2015
10
Metastatic relapse after initial clinical stage I testicular Leydig cell tumor. 62
24855728 2014
11
Testicular Leydig cell tumor diagnosed on fine needle aspiration. 62
20737589 2010
12
F-18 FDG PET/CT imaging of a Leydig cell tumor. 62
20173460 2010
13
Value of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor. 62
27307872 2010
14
[Testicular Leydig cell tumor presenting as male infertility: a case report]. 62
20048565 2009
15
Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. 62
18041368 2007
16
Re: Long-term follow-up and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 62
17437857 2007
17
Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. 62
17070249 2006
18
[An uncommon cause of gynecomastia: testicular Leydig cell tumor. Hormonal profile before and after orchiectomy]. 62
16671273 2006
19
Testicular leydig cell tumor presenting as primary infertility. 62
17018455 2002
20
Intracytoplasmic and intranuclear Reinke's crystals in a testicular Leydig-cell tumor diagnosed by fine-needle aspiration cytology: a case report with review of the literature. 62
11536438 2001
21
Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. 62
11545298 2001
22
Spontaneous neoplastic lesions in aged Sprague-Dawley rats. 62
11381627 2001
23
[Precocious puberty caused by a testicular Leydig cell tumor]. 62
11232155 2001
24
[The Leydig-cell testicular tumor. A case report with magnetic resonance images]. 62
9887568 1998
25
Localization of the steroidogenic acute regulatory protein in human tissues. 62
9398748 1997
26
Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture. 62
8732455 1996
27
[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. 62
7702009 1995
28
Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology. A case report. 62
8147220 1994
29
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. 62
8105109 1993
30
Benign Leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of Leser-Trélat. 62
8396689 1993
31
Ultrasound and CT of a calcified testicular Leydig cell tumor. 62
1522284 1992
32
Transformed murine leydig-cells in serum-free culture - useful model for analyses of steroid hormone-induced cell-growth and cell morphology (review). 62
21584561 1992
33
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. 62
1387343 1992
34
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor. 62
1751389 1991
35
[Adrenal adenoma with bilateral testicular Leydig cell tumor: a case report]. 62
1957732 1991
36
Low expression of 3 beta-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures. 62
1848566 1991
37
[Testicular leydig cell tumor in a child: a case report]. 62
2694835 1989
38
[A case of intra-scrotal and extra-testicular Leydig cell tumor]. 62
2696424 1989
39
[Bilateral testicular Leydig cell tumor. Procedure to follow]. 62
3045206 1988
40
Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. 62
3818898 1987
41
Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. 62
3896459 1985
42
[Testicular Leydig cell tumor. A case]. 62
6234579 1984
43
Ultrastructure of feminizing testicular Leydig cell tumors. 62
7157496 1982
44
[Feminizing testicular Leydig cell tumor. Case contribution to the differential diagnosis of gynecomastia]. 62
7268342 1981
45
Effects of a feminizing testicular Leydig cell tumour on nontumorous testicular tissue: an ultrastructual study. 62
844220 1977
46
[A case of testicular Leydig cell tumor with gynecomastia]. 62
13138998 1953

Variations for Testicular Leydig Cell Tumor

Expression for Testicular Leydig Cell Tumor

Search GEO for disease gene expression data for Testicular Leydig Cell Tumor.

Pathways for Testicular Leydig Cell Tumor

GO Terms for Testicular Leydig Cell Tumor

Biological processes related to Testicular Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cAMP-mediated signaling GO:0043951 8.92 RNF157 PDE11A

Sources for Testicular Leydig Cell Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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