MCID: TST004
MIFTS: 38

Testicular Lymphoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases, Reproductive diseases

Aliases & Classifications for Testicular Lymphoma

MalaCards integrated aliases for Testicular Lymphoma:

Name: Testicular Lymphoma 12 15 37
Malignant Lymphoma of Testis 12 70
Lymphoma of the Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12253
NCIt 50 C6810
SNOMED-CT 67 277664004
UMLS 70 C0349644

Summaries for Testicular Lymphoma

MalaCards based summary : Testicular Lymphoma, also known as malignant lymphoma of testis, is related to follicular lymphoma and primary central nervous system lymphoma. An important gene associated with Testicular Lymphoma is CD274 (CD274 Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include testis, bone marrow and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Testicular Lymphoma

Diseases related to Testicular Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 follicular lymphoma 30.5 MME IRF4 BCL6
2 primary central nervous system lymphoma 30.2 MYD88 BCL6
3 lymphoma, hodgkin, classic 30.2 TNFRSF8 IRF4 BCL6
4 lymphoma 30.1 TNFRSF8 PDCD1 MYD88 IRF4 CD274 BCL6
5 lymphoblastic lymphoma 30.1 TNFRSF8 MME BCL6
6 myeloid sarcoma 30.0 IRF4 CD79A CD274
7 lymphosarcoma 29.9 TNFRSF8 BCL6
8 burkitt lymphoma 29.7 TNFRSF8 MME IRF4 BCL6
9 intraocular lymphoma 29.7 IGHV4-38-2 BCL6
10 central nervous system lymphoma 29.5 PDCD1LG2 MYD88 FOXP1 CD274 BCL6
11 peripheral t-cell lymphoma 29.3 TNFRSF8 PDCD1 MME CD274 BCL6
12 mature t-cell and nk-cell lymphoma 29.3 TNFRSF8 MME CD79A BCL6
13 immune deficiency disease 29.2 TNFRSF8 PDCD1 CIITA CD79A BCL6
14 b-cell lymphoma 29.1 TNFRSF8 MYD88 MME IRF4 FOXP1 CIITA
15 composite lymphoma 28.8 TNFRSF8 MME IGHV4-38-2 CD79A CD274 BCL6
16 lymphoma, non-hodgkin, familial 28.6 TNFRSF8 MYD88 MME IRF4 IGHV4-38-2 CD79B
17 diffuse large b-cell lymphoma 28.5 TNFRSF8 PDCD1 MYD88 MME IRF4 FOXP1
18 nodular lymphocyte predominant hodgkin lymphoma 10.3 PDCD1 BCL6
19 mixed oligodendroglioma-astrocytoma 10.3 PDCD1 CD274
20 ureteral lymphoma 10.3 MME BCL6
21 prostate lymphoma 10.2 MME BCL6
22 heart lymphoma 10.2 MME BCL6
23 ovarian lymphoma 10.2 MME BCL6
24 appendix lymphoma 10.2 MME BCL6
25 primary cutaneous t-cell lymphoma 10.2 TNFRSF8 PDCD1
26 autoimmune cardiomyopathy 10.2 PDCD1LG2 PDCD1 CD274
27 type 1 diabetes mellitus 21 10.2 PDCD1LG2 PDCD1 CD274
28 lung non-squamous non-small cell carcinoma 10.2 PDCD1LG2 PDCD1 CD274
29 gastroesophageal junction adenocarcinoma 10.2 PDCD1LG2 PDCD1 CD274
30 myopathy, distal, 1 10.2 PDCD1LG2 PDCD1 CD274
31 retroperitoneal lymphoma 10.2 TNFRSF8 MME
32 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 TNFRSF8 BCL6
33 hilar lung carcinoma 10.2 MME CD79A
34 lung hilum cancer 10.2 MME CD79A
35 orbital cellulitis 10.1 TNFRSF8 MME
36 acute orbital inflammation 10.1 TNFRSF8 MME
37 uterine carcinosarcoma 10.1 PDCD1 MME CD274
38 gamma heavy chain disease 10.1 MYD88 IGHV4-38-2
39 liver lymphoma 10.1 MME CD79A
40 agammaglobulinemia, non-bruton type 10.1 CD79B CD79A
41 vitiligo-associated multiple autoimmune disease susceptibility 1 10.1 PDCD1 CIITA CD274
42 lymphoepithelioma-like carcinoma 10.1 TNFRSF8 PDCD1 CD274
43 sclerosing hepatic carcinoma 10.1 MME CD79A
44 central epithelioid sarcoma 10.1 TNFRSF8 MME
45 vulvar proximal-type epithelioid sarcoma 10.1 TNFRSF8 MME
46 chromophobe renal cell carcinoma 10.1 PDCD1 MME CD274
47 extramedullary plasmacytoma 10.1 IRF4 CD79A
48 hodgkin's lymphoma, lymphocytic depletion 10.1 TNFRSF8 CD79A
49 relapsed/refractory diffuse large b-cell lymphoma 10.1 FOXP1 CD79B
50 reticulum cell sarcoma 10.1

Graphical network of the top 20 diseases related to Testicular Lymphoma:



Diseases related to Testicular Lymphoma

Symptoms & Phenotypes for Testicular Lymphoma

MGI Mouse Phenotypes related to Testicular Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 BCL6 CD274 CD79A CD79B CIITA IRF4
2 immune system MP:0005387 9.7 BCL6 CD274 CD79A CD79B CIITA IRF4
3 no phenotypic analysis MP:0003012 9.1 BCL6 CD274 CD79A CD79B MYD88 PDCD1LG2

Drugs & Therapeutics for Testicular Lymphoma

Drugs for Testicular Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antineoplastic Agents, Immunological Phase 2
3
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
4 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Open-label, Single-arm, Two-cohort Study of Nivolumab in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) or Relapsed/Refractory Primary Testicular Lymphoma (PTL) Active, not recruiting NCT02857426 Phase 2 Nivolumab
2 Phase I Study of Dasatinib in Recipients of Allogeneic Stem Cell Transplantation for Hematologic Malignancies. Terminated NCT01643603 Phase 1 Dasatinib
3 Phase I Study of Dasatinib in Recipients of Autologous Stem Cell Transplantation for Hematologic Malignancies. Terminated NCT01609816 Phase 1 Dasatinib

Search NIH Clinical Center for Testicular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Testicular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Testicular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Testicular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Testicular Lymphoma

Anatomical Context for Testicular Lymphoma

MalaCards organs/tissues related to Testicular Lymphoma:

40
Testis, Bone Marrow, Bone, Kidney, Testes, Myeloid

Publications for Testicular Lymphoma

Articles related to Testicular Lymphoma:

(show top 50) (show all 239)
# Title Authors PMID Year
1
Ineffectiveness of High-Dose Methotrexate for Prevention of CNS Relapse in Diffuse Large B Cell Lymphoma. 61
33811794 2021
2
Imaging of primary testicular lymphoma with unusual intraabdominal spread along the spermatic cord and gonadal vein. 61
33363674 2021
3
Serum levels of microRNA-371a-3p are not elevated in testicular tumours of non-germ cell origin. 61
33200255 2021
4
Nivolumab-caused hyperprogression of diffuse large B-cell lymphoma of the testis and spontaneous remission of type 2 diabetes mellitus in an elderly patient: a case report. 61
33595946 2021
5
Clinicopathologic features, outcomes, and prognostic factors of testicular sarcoma: a population-based study. 61
32895865 2021
6
The immune contexture of primary central nervous system diffuse large B cell lymphoma associates with patient survival and specific cell signaling. 61
33664848 2021
7
Radical inguinal orchidectomy: the gold standard for initial management of testicular cancer. 61
33457282 2020
8
Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma. 61
32911592 2020
9
Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation. 61
31241561 2020
10
Combined chemotherapy and radiotherapy improves survival in 1897 testicular Lymphoma patients from a contemporary cohort. 61
32307328 2020
11
Immune checkpoint inhibitors in malignant lymphoma: Advances and perspectives. 61
32694896 2020
12
Testicular Lymphoma: A Rare Cause of a Testicular Mass. 61
32580865 2020
13
Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial. 61
32171071 2020
14
Adult primary testicular lymphoma: clinical features and survival in a series of patients treated at a high-volume institution in China. 61
32171265 2020
15
Primary testicular diffuse large B-cell lymphoma: Case series. 61
32195944 2020
16
Diffuse Large B-cell Lymphoma of Testis: a Case Report and Current Literature Review. 61
32337891 2020
17
TBL1XR1 mutation predicts poor outcome in primary testicular diffuse large B-cell lymphoma patients. 61
32322395 2020
18
Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial. 61
31868632 2019
19
Amplification of 9p24.1 in diffuse large B-cell lymphoma identifies a unique subset of cases that resemble primary mediastinal large B-cell lymphoma. 61
31471540 2019
20
Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma. 61
31082690 2019
21
Primary testicular lymphoma: A SEER analysis of 1,169 cases. 61
30867741 2019
22
Role of 18F-FDG Positron Emission Tomography/Computed Tomography Imaging in Testicular Lymphoma 61
30942064 2019
23
Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma. 61
30489610 2019
24
A case of primary testicular lymphoma with continuous spread along the gonadal vein and spermatic cord. 61
31131131 2019
25
Radiation therapy in primary testicular lymphoma: does practice match the standard of care? 61
29966467 2019
26
T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma. 61
30237271 2019
27
Two Cases of Primary Testicular Lymphoma Presenting with Direct Spread along the Spermatic Cord and Gonadal Vessels. 61
31316854 2019
28
The Prognostic Value of Blood-Based Biomarkers in Patients With Testicular Diffuse Large B-Cell Lymphoma. 61
31921649 2019
29
Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma. 61
30338457 2018
30
[High-frequency ultrasonographic characteristics and clinical features of primary testicular lymphoma in children]. 61
32212490 2018
31
The survival and prognostic factors of primary testicular lymphoma: two-decade single-center experience. 61
30246707 2018
32
PD-L1+ tumor-associated macrophages and PD-1+ tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma. 61
30026337 2018
33
Testicular cancer among US men aged 50 years and older. 61
29807233 2018
34
Utility of FDG PET/CT in the Management of Primary Testicular Lymphoma. 61
29889027 2018
35
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence. 61
29931605 2018
36
[Primary testicular NK/T cell lymphoma: a clinicopathologic analysis of six cases]. 61
29534354 2018
37
Primary diffuse large B-cell lymphoma of the testis. 61
30173267 2018
38
Detection of the MYD88 p.L265P Mutation in the CSF of a Patient With Secondary Central Nervous System Lymphoma. 61
30294590 2018
39
Posttransplant Lymphoproliferative Disorder Presenting as Testicular Lymphoma in a Kidney Transplant Recipient: A Case Report and Review of the Literature. 61
29666729 2018
40
Clinical and histological features of primary testicular diffuse large B-cell lymphoma: a single center experience in China. 61
29348832 2017
41
Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma. 61
29296917 2017
42
High-dose chemotherapy with autologous stem cell transplantation following systemic chemotherapy, prophylactic intrathecal methotrexate, and radiotherapy prevents relapse and improves the outcome of advanced stage primary testicular lymphoma even with cardiac involvement. 61
28883219 2017
43
Efficacy of prophylactic irradiation to the contralateral testis for patients with advanced-stage primary testicular lymphoma: an analysis of outcomes at a single institution. 61
28612278 2017
44
"The moon on the water": a characteristic ultrasonographic appearance of testicular lymphoma. 61
29135132 2017
45
PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma. 61
28356247 2017
46
Bilateral hydrocele. Uncommon clinical presentation of primary testicular lymphoma in the elderly. 61
28383626 2017
47
Multiparametric Sonography of Hematologic Malignancies of the Testis: Grayscale, Color Doppler, and Contrast-Enhanced Ultrasound and Strain Elastographic Appearances With Histologic Correlation. 61
28032907 2017
48
[Primary testicular lymphoma]. 61
28840738 2017
49
HLA dependent immune escape mechanisms in B-cell lymphomas: Implications for immune checkpoint inhibitor therapy? 61
28507804 2017
50
[The clinical characteristics and outcomes of 16 Burkitt' s lymphoma with testicular involvement]. 61
27719719 2016

Variations for Testicular Lymphoma

Expression for Testicular Lymphoma

Search GEO for disease gene expression data for Testicular Lymphoma.

Pathways for Testicular Lymphoma

Pathways related to Testicular Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 TNFRSF8 PDCD1LG2 PDCD1 MYD88 MME IRF4
2
Show member pathways
13.11 PDCD1LG2 PDCD1 MYD88 CD79B CD79A CD274
3
Show member pathways
12.21 PDCD1 MYD88 IRF4 CD274
4
Show member pathways
11.95 IRF4 CD79B CD79A BCL6
5
Show member pathways
11.89 PDCD1LG2 PDCD1 CD274
6 11.79 TNFRSF8 PDCD1LG2 PDCD1 MYD88 IRF4 CIITA
7 11.78 PDCD1LG2 PDCD1 CD274
8 11.64 MME CD79B CD79A
9
Show member pathways
11.54 PDCD1LG2 PDCD1 CD274
10 11.08 PDCD1LG2 PDCD1 CD274 BCL6

GO Terms for Testicular Lymphoma

Cellular components related to Testicular Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 PDCD1LG2 PDCD1 IGHV4-38-2 CD79B CD79A CD274
2 B cell receptor complex GO:0019815 8.96 CD79B CD79A

Biological processes related to Testicular Lymphoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 PDCD1LG2 CIITA CD79B CD274
2 adaptive immune response GO:0002250 9.72 PDCD1LG2 PDCD1 CD79B CD79A CD274
3 cellular response to lipopolysaccharide GO:0071222 9.71 PDCD1LG2 MYD88 CD274
4 B cell receptor signaling pathway GO:0050853 9.67 IGHV4-38-2 CD79B CD79A
5 regulation of inflammatory response GO:0050727 9.61 MYD88 FOXP1 BCL6
6 B cell differentiation GO:0030183 9.54 CD79B CD79A BCL6
7 defense response to protozoan GO:0042832 9.52 MYD88 IRF4
8 negative regulation of interleukin-10 production GO:0032693 9.51 PDCD1LG2 CD274
9 negative regulation of activated T cell proliferation GO:0046007 9.48 PDCD1LG2 CD274
10 regulation of tumor necrosis factor production GO:0032680 9.46 MYD88 FOXP1
11 T cell costimulation GO:0031295 9.43 PDCD1LG2 PDCD1 CD274
12 negative regulation of B cell apoptotic process GO:0002903 9.4 FOXP1 BCL6
13 cell surface receptor signaling pathway GO:0007166 9.35 PDCD1LG2 MYD88 CD79B CD79A CD274
14 immune system process GO:0002376 9.23 PDCD1LG2 PDCD1 MYD88 IRF4 CD79B CD79A
15 regulation of chemokine (C-X-C motif) ligand 2 production GO:2000341 9.16 MYD88 FOXP1

Sources for Testicular Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....