MCID: TST004
MIFTS: 38

Testicular Lymphoma

Categories: Cancer diseases, Endocrine diseases, Immune diseases, Reproductive diseases

Aliases & Classifications for Testicular Lymphoma

MalaCards integrated aliases for Testicular Lymphoma:

Name: Testicular Lymphoma 12 15 37
Malignant Lymphoma of Testis 12 71
Lymphoma of the Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12253
NCIt 49 C6810
UMLS 71 C0349644

Summaries for Testicular Lymphoma

MalaCards based summary : Testicular Lymphoma, also known as malignant lymphoma of testis, is related to follicular lymphoma and primary central nervous system lymphoma. An important gene associated with Testicular Lymphoma is CD274 (CD274 Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Pembrolizumab and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include b cells, testis and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Testicular Lymphoma

Diseases related to Testicular Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 follicular lymphoma 30.3 MME IRF4 BCL6
2 primary central nervous system lymphoma 30.2 MYD88 BCL6
3 lymphoma, hodgkin, classic 30.1 TNFRSF8 IRF4 BCL6
4 central nervous system lymphoma 30.1 MYD88 CD274 BCL6
5 lymphosarcoma 29.8 TNFRSF8 BCL6
6 lymphoma 29.8 TNFRSF8 PDCD1 MYD88 MME IRF4 CD274
7 lymphoblastic lymphoma 29.8 TNFRSF8 MME BCL6
8 mantle cell lymphoma 29.7 MME CD274 BCL6
9 burkitt lymphoma 29.4 TNFRSF8 MME IRF4 BCL6
10 composite lymphoma 29.0 TNFRSF8 MME CD79A BCL6
11 peripheral t-cell lymphoma 28.9 TNFRSF8 PDCD1 MME CD274 BCL6
12 b-cell lymphoma 28.5 TNFRSF8 MYD88 MME IRF4 CIITA CD79B
13 lymphoma, non-hodgkin, familial 28.5 TNFRSF8 MYD88 MME IRF4 CD79B CD79A
14 diffuse large b-cell lymphoma 28.3 TNFRSF8 PDCD1 MYD88 MME IRF4 CD79B
15 immune deficiency disease 28.3 TNFRSF8 IRF4 CIITA CD79A BCL6
16 mixed oligodendroglioma-astrocytoma 10.4 PDCD1 CD274
17 ureteral lymphoma 10.3 MME BCL6
18 heart lymphoma 10.3 MME BCL6
19 ovarian lymphoma 10.3 MME BCL6
20 autoimmune disease of cardiovascular system 10.2 PDCD1LG2 CD274
21 epstein-barr virus-associated gastric carcinoma 10.2 PDCD1LG2 CD274
22 selective igg deficiency disease 10.2 IRF4 CD79A
23 primary cutaneous t-cell lymphoma 10.2 TNFRSF8 PDCD1
24 small intestine lymphoma 10.2 CD79A BCL6
25 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 TNFRSF8 BCL6
26 autoimmune cardiomyopathy 10.2 PDCD1LG2 PDCD1 CD274
27 diabetes mellitus, insulin-dependent, 21 10.2 PDCD1LG2 PDCD1 CD274
28 myopathy, distal, 1 10.2 PDCD1LG2 PDCD1 CD274
29 hilar lung carcinoma 10.2 MME CD79A
30 lung hilum cancer 10.2 MME CD79A
31 heavy chain disease 10.1 MYD88 CD79A
32 lymphoepithelioma-like thymic carcinoma 10.1 TNFRSF8 CD274
33 autoimmune lymphoproliferative syndrome, type v 10.1 TNFRSF8 BCL6
34 sclerosing hepatic carcinoma 10.1 MME CD79A
35 extramedullary plasmacytoma 10.1 IRF4 CD79A
36 chromophobe renal cell carcinoma 10.1 PDCD1 MME CD274
37 peripartum cardiomyopathy 10.1 PDCD1 CD274
38 agammaglobulinemia, non-bruton type 10.1 CD79B CD79A
39 seminoma 10.0
40 lymphoepithelioma-like carcinoma 10.0 TNFRSF8 PDCD1 CD274
41 central epithelioid sarcoma 10.0 TNFRSF8 MME
42 vulvar proximal-type epithelioid sarcoma 10.0 TNFRSF8 MME
43 t-cell adult acute lymphocytic leukemia 10.0 TNFRSF8 IRF4
44 viral infectious disease 10.0 PDCD1 MYD88 CD274
45 nodular lymphocyte predominant hodgkin lymphoma 10.0 TNFRSF8 PDCD1 BCL6
46 cheilitis 10.0 PDCD1 CD274
47 infected hydrocele 10.0 TNFRSF8 CD79A
48 mediastinal gray zone lymphoma 10.0 TNFRSF8 CD79A
49 primary cutaneous diffuse large b-cell lymphoma, leg type 10.0 PDCD1LG2 MYD88 IRF4 CD274
50 adult t-cell leukemia 10.0 TNFRSF8 IRF4 CD274

Graphical network of the top 20 diseases related to Testicular Lymphoma:



Diseases related to Testicular Lymphoma

Symptoms & Phenotypes for Testicular Lymphoma

MGI Mouse Phenotypes related to Testicular Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 BCL6 CD274 CD79A CD79B CIITA IRF4
2 homeostasis/metabolism MP:0005376 9.96 BCL6 CD274 CD79A CIITA IRF4 MME
3 immune system MP:0005387 9.9 BCL6 CD274 CD79A CD79B CIITA IRF4
4 neoplasm MP:0002006 9.35 CD79A IRF4 MYD88 PDCD1 PDCD1LG2
5 no phenotypic analysis MP:0003012 9.1 BCL6 CD274 CD79A CD79B MYD88 PDCD1LG2

Drugs & Therapeutics for Testicular Lymphoma

Drugs for Testicular Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2
nivolumab Approved Phase 2 946414-94-4
3
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
4 Protein Kinase Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Trial of Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma(PCNSL), and Other Extranodal Diffuse Large B-cell Lymphomas Recruiting NCT03255018 Phase 2
2 A Phase 2, Open-label, Single-arm, Two-cohort Study of Nivolumab in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) or Relapsed/Refractory Primary Testicular Lymphoma (PTL) Active, not recruiting NCT02857426 Phase 2 Nivolumab
3 Phase I/II Study of Dasatinib in Recipients of Autologous Stem Cell Transplantation for Hematologic Malignancies. Active, not recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
4 Phase I/II Study of Dasatinib in Recipients of Allogeneic Stem Cell Transplantation for Hematologic Malignancies. Active, not recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
5 Phase II Study Of Durvalumab In Combination With Lenalidomide In Relapsed/Refractory EBV Associated Subtypes Of DLBCL, Primary CNS Lymphoma And Primary Testicular DLBCL - DuRIANS (Durvalumab Revlimid In Aggressive NHL Subtypes) Withdrawn NCT03212807 Phase 2 Durvalumab;Lenalidomide

Search NIH Clinical Center for Testicular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Testicular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Testicular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Testicular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Testicular Lymphoma

Anatomical Context for Testicular Lymphoma

MalaCards organs/tissues related to Testicular Lymphoma:

40
B Cells, Testis, T Cells, Bone, Lung, Prostate, Kidney

Publications for Testicular Lymphoma

Articles related to Testicular Lymphoma:

(show top 50) (show all 222)
# Title Authors PMID Year
1
Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial. 61
31868632 2020
2
Amplification of 9p24.1 in diffuse large B-cell lymphoma identifies a unique subset of cases that resemble primary mediastinal large B-cell lymphoma. 61
31471540 2019
3
Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma. 61
31082690 2019
4
Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation. 61
31241561 2019
5
Primary testicular lymphoma: A SEER analysis of 1,169 cases. 61
30867741 2019
6
Role of 18F-FDG Positron Emission Tomography/Computed Tomography Imaging in Testicular Lymphoma 61
30942064 2019
7
Radiation therapy in primary testicular lymphoma: does practice match the standard of care? 61
29966467 2019
8
A case of primary testicular lymphoma with continuous spread along the gonadal vein and spermatic cord. 61
31131131 2019
9
T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma. 61
30237271 2019
10
Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma. 61
30489610 2019
11
The Prognostic Value of Blood-Based Biomarkers in Patients With Testicular Diffuse Large B-Cell Lymphoma. 61
31921649 2019
12
Two Cases of Primary Testicular Lymphoma Presenting with Direct Spread along the Spermatic Cord and Gonadal Vessels. 61
31316854 2019
13
Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma. 61
30338457 2018
14
PD-L1+ tumor-associated macrophages and PD-1+ tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma. 61
30026337 2018
15
The survival and prognostic factors of primary testicular lymphoma: two-decade single-center experience. 61
30246707 2018
16
Testicular cancer among US men aged 50 years and older. 61
29807233 2018
17
Utility of FDG PET/CT in the Management of Primary Testicular Lymphoma. 61
29889027 2018
18
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence. 61
29931605 2018
19
[Primary testicular NK/T cell lymphoma: a clinicopathologic analysis of six cases]. 61
29534354 2018
20
Primary diffuse large B-cell lymphoma of the testis. 61
30173267 2018
21
Posttransplant Lymphoproliferative Disorder Presenting as Testicular Lymphoma in a Kidney Transplant Recipient: A Case Report and Review of the Literature. 61
29666729 2018
22
Detection of the MYD88 p.L265P Mutation in the CSF of a Patient With Secondary Central Nervous System Lymphoma. 61
30294590 2018
23
Clinical and histological features of primary testicular diffuse large B-cell lymphoma: a single center experience in China. 61
29348832 2017
24
Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma. 61
29296917 2017
25
High-dose chemotherapy with autologous stem cell transplantation following systemic chemotherapy, prophylactic intrathecal methotrexate, and radiotherapy prevents relapse and improves the outcome of advanced stage primary testicular lymphoma even with cardiac involvement. 61
28883219 2017
26
Efficacy of prophylactic irradiation to the contralateral testis for patients with advanced-stage primary testicular lymphoma: an analysis of outcomes at a single institution. 61
28612278 2017
27
"The moon on the water": a characteristic ultrasonographic appearance of testicular lymphoma. 61
29135132 2017
28
PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma. 61
28356247 2017
29
Bilateral hydrocele. Uncommon clinical presentation of primary testicular lymphoma in the elderly. 61
28383626 2017
30
Multiparametric Sonography of Hematologic Malignancies of the Testis: Grayscale, Color Doppler, and Contrast-Enhanced Ultrasound and Strain Elastographic Appearances With Histologic Correlation. 61
28032907 2017
31
HLA dependent immune escape mechanisms in B-cell lymphomas: Implications for immune checkpoint inhibitor therapy? 61
28507804 2017
32
[Primary testicular lymphoma]. 61
28840738 2017
33
[The clinical characteristics and outcomes of 16 Burkitt' s lymphoma with testicular involvement]. 61
27719719 2016
34
Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma: An Analysis of 145 Consecutive Cases and Testicular Lymphomas. 61
27035612 2016
35
Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis. 61
27630854 2016
36
Straight Vessel Pattern and Rapid Filling Time: Characteristic Findings on Contrast-Enhanced Sonography of Testicular Lymphoma. 61
27335443 2016
37
Primary Paratesticular Lymphoma with Testicular Sparing: Account of an Unusual Scrotal Mass. 61
27134882 2016
38
Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium. 61
26308769 2016
39
Primary testicular lymphoma. 61
26433344 2016
40
Primary testicular lymphoma: Two case reports and review of the literature. 61
26766810 2016
41
Isolated Central Nervous System Relapse After 10 Years in a Case of Primary Testicular Lymphoma Detected on (18)F-FDG PET/CT. 61
26550055 2015
42
Unusual continuous intra-abdominal spread of primary testicular lymphoma along the spermatic cord and gonadal vessels: Report of 2 cases. 61
26649126 2015
43
[Diffuse large B-cell lymphoma of the testis relapsed 16 years after achieving complete response]. 61
26725353 2015
44
High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses. 61
26388135 2015
45
Primary testicular lymphoma with solitary cutaneous nodule as the initial presentation. 61
26664513 2015
46
Primary testicular lymphoma: a single centre experience. 61
26422109 2015
47
[Testicular lymphoma: a clinicopathological study of 65 cases]. 61
26462778 2015
48
Grayscale and color Doppler features of testicular lymphoma. 61
26014335 2015
49
Recurrent genomic rearrangements in primary testicular lymphoma. 61
25712539 2015
50
[A case of primary testicular diffuse large B-cell lymphoma with a p53 gene point mutation]. 61
25981657 2015

Variations for Testicular Lymphoma

Expression for Testicular Lymphoma

Search GEO for disease gene expression data for Testicular Lymphoma.

Pathways for Testicular Lymphoma

Pathways related to Testicular Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 TNFRSF8 PDCD1LG2 PDCD1 MYD88 MME IRF4
2
Show member pathways
13.11 PDCD1LG2 PDCD1 MYD88 CD79B CD79A CD274
3
Show member pathways
12.25 PDCD1 MYD88 IRF4 CD274
4
Show member pathways
12.02 IRF4 CD79B CD79A BCL6
5
Show member pathways
11.91 PDCD1LG2 PDCD1 CD274
6 11.82 PDCD1LG2 PDCD1 CD274
7 11.79 TNFRSF8 PDCD1LG2 PDCD1 MYD88 IRF4 CIITA
8 11.67 MME CD79B CD79A
9
Show member pathways
11.58 PDCD1LG2 PDCD1 CD274
10 11.22 TNFRSF8 PDCD1LG2 PDCD1 CD274
11 11.1 CIITA CD79A
12 11.08 IRF4 CIITA
13 10.98 TNFRSF8 PDCD1 MME BCL6

GO Terms for Testicular Lymphoma

Cellular components related to Testicular Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 PDCD1LG2 PDCD1 CD79B CD79A CD274
2 B cell receptor complex GO:0019815 8.96 CD79B CD79A

Biological processes related to Testicular Lymphoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 PDCD1LG2 CIITA CD79B CD274
2 cellular response to lipopolysaccharide GO:0071222 9.63 PDCD1LG2 MYD88 CD274
3 adaptive immune response GO:0002250 9.55 PDCD1LG2 PDCD1 CD79B CD79A CD274
4 B cell differentiation GO:0030183 9.5 CD79B CD79A BCL6
5 negative regulation of interferon-gamma production GO:0032689 9.49 PDCD1LG2 CD274
6 defense response to protozoan GO:0042832 9.43 MYD88 IRF4
7 T cell costimulation GO:0031295 9.43 PDCD1LG2 PDCD1 CD274
8 negative regulation of interleukin-10 production GO:0032693 9.4 PDCD1LG2 CD274
9 negative regulation of activated T cell proliferation GO:0046007 9.37 PDCD1LG2 CD274
10 cell surface receptor signaling pathway GO:0007166 9.35 PDCD1LG2 MYD88 CD79B CD79A CD274
11 immune system process GO:0002376 9.23 PDCD1LG2 PDCD1 MYD88 IRF4 CD79B CD79A

Molecular functions related to Testicular Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.44 TNFRSF8 PNLIP PDCD1LG2 PDCD1 MYD88 MME
2 transmembrane signaling receptor activity GO:0004888 9.13 TNFRSF8 CD79B CD79A

Sources for Testicular Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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