MCID: TST017
MIFTS: 18

Testicular Malignant Germ Cell Cancer

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Malignant Germ Cell Cancer

MalaCards integrated aliases for Testicular Malignant Germ Cell Cancer:

Name: Testicular Malignant Germ Cell Cancer 12 15
Malignant Germ Cell Tumor of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5556
NCIt 50 C9063
SNOMED-CT 67 713646001
UMLS 70 C0855197

Summaries for Testicular Malignant Germ Cell Cancer

MalaCards based summary : Testicular Malignant Germ Cell Cancer, also known as malignant germ cell tumor of testis, is related to mixed hepatoblastoma and scrotum neoplasm. An important gene associated with Testicular Malignant Germ Cell Cancer is SERPINA3 (Serpin Family A Member 3). Affiliated tissues include testis, liver and bone.

Related Diseases for Testicular Malignant Germ Cell Cancer

Diseases in the Testicular Germ Cell Cancer family:

Testicular Malignant Germ Cell Cancer

Diseases related to Testicular Malignant Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 mixed hepatoblastoma 10.3 SERPINA3 AFP
2 scrotum neoplasm 10.3 SERPINA3 AFP
3 pancreas sarcoma 10.3 SERPINA3 AFP
4 liver sarcoma 10.2 SERPINA3 AFP
5 pancreatic acinar cell adenocarcinoma 10.2 SERPINA3 AFP
6 cystic lymphangioma 10.2 SERPINA3 AFP
7 pancreatoblastoma 10.2 SERPINA3 AFP
8 pancreatic endocrine carcinoma 10.2 SERPINA3 AFP
9 opisthorchiasis 10.2 SERPINA3 AFP
10 sclerosing hepatic carcinoma 10.2 GPC3 AFP
11 mixed cell type cancer 10.2 SERPINA3 AFP
12 sarcomatous intrahepatic cholangiocarcinoma 10.2 GPC3 AFP
13 embryonal sarcoma 10.2 SERPINA3 GPC3
14 plasma protein metabolism disease 10.2 SERPINA3 AFP
15 extragonadal seminoma 10.2 SALL4 AFP
16 choriocarcinoma of the testis 10.2 SALL4 AFP
17 trophoblastic neoplasm 10.2 SERPINA3 AFP
18 liver leiomyosarcoma 10.2 GPC3 AFP
19 acinar cell carcinoma 10.2 SERPINA3 AFP
20 seminal vesicle adenocarcinoma 10.2 GPC3 AFP
21 central nervous system germ cell tumor 10.2 SALL4 AFP
22 liver benign neoplasm 10.2 GPC3 AFP
23 ovarian solid teratoma 10.2 TNFRSF8 AFP
24 intermediate malignant teratoma 10.1 TNFRSF8 AFP
25 testicular infarct 10.1 TNFRSF8 AFP
26 lethal midline granuloma 10.1 TNFRSF8 SERPINA3
27 gastrointestinal lymphoma 10.1 TNFRSF8 SERPINA3
28 infected hydrocele 10.1 TNFRSF8 AFP
29 reproductive organ benign neoplasm 10.1 SERPINA3 AFP
30 intratubular embryonal carcinoma 10.1 TNFRSF8 AFP
31 histiocytic and dendritic cell cancer 10.1 TNFRSF8 SERPINA3
32 spermatocytoma 10.1 SALL4 AFP
33 mediastinal cancer 10.1 TNFRSF8 AFP
34 embryonal testis carcinoma 10.1 TNFRSF8 AFP
35 fibrosarcoma of bone 10.1 TNFRSF8 SERPINA3
36 fibrolamellar carcinoma 10.1 GPC3 AFP
37 vein disease 10.1 SERPINA3 AFP
38 childhood endodermal sinus tumor 10.1 GDF3 AFP
39 placental site trophoblastic tumor 10.1 SALL4 GPC3
40 germinoma 10.1 SALL4 AFP
41 reticulosarcoma 10.1 TNFRSF8 SERPINA3
42 bile duct adenocarcinoma 10.0 SERPINA3 GPC3 AFP
43 germ cell cancer 10.0 SERPINA3 SALL4 AFP
44 benign teratoma 10.0 SALL4 AFP
45 cystadenoma 10.0 SERPINA3 AFP
46 dysgerminoma 10.0 SALL4 AFP
47 hepatocellular adenoma 10.0 GPC3 AFP
48 testicular disease 10.0 TNFRSF8 SERPINA3 AFP
49 ovarian primitive germ cell tumor 10.0 SALL4 GPC3 AFP
50 ovarian endodermal sinus tumor 10.0 SALL4 GPC3 AFP

Graphical network of the top 20 diseases related to Testicular Malignant Germ Cell Cancer:



Diseases related to Testicular Malignant Germ Cell Cancer

Symptoms & Phenotypes for Testicular Malignant Germ Cell Cancer

Drugs & Therapeutics for Testicular Malignant Germ Cell Cancer

Search Clinical Trials , NIH Clinical Center for Testicular Malignant Germ Cell Cancer

Genetic Tests for Testicular Malignant Germ Cell Cancer

Anatomical Context for Testicular Malignant Germ Cell Cancer

MalaCards organs/tissues related to Testicular Malignant Germ Cell Cancer:

40
Testis, Liver, Bone, Pancreas

Publications for Testicular Malignant Germ Cell Cancer

Variations for Testicular Malignant Germ Cell Cancer

Expression for Testicular Malignant Germ Cell Cancer

Search GEO for disease gene expression data for Testicular Malignant Germ Cell Cancer.

Pathways for Testicular Malignant Germ Cell Cancer

GO Terms for Testicular Malignant Germ Cell Cancer

Biological processes related to Testicular Malignant Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial cell proliferation GO:0050680 8.96 RUNX3 GPC3
2 SMAD protein signal transduction GO:0060395 8.62 GDF3 AFP

Sources for Testicular Malignant Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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