MCID: TST025
MIFTS: 32

Testicular Microlithiasis

Categories: Reproductive diseases

Aliases & Classifications for Testicular Microlithiasis

MalaCards integrated aliases for Testicular Microlithiasis:

Name: Testicular Microlithiasis 58 30 13 41 74

Classifications:



External Ids:

OMIM 58 610441
MedGen 43 C1864873
SNOMED-CT via HPO 70 117261000119108
UMLS 74 C1864873

Summaries for Testicular Microlithiasis

OMIM : 58 Testicular microlithiasis, the deposition of calcium phosphate microliths within the seminiferous tubules, has a population prevalence of 0.6 to 9% (Kim et al., 2003). Middleton et al. (2002) found that it was associated with a majority of primary testicular malignancies. Miller and Sidhu (2002) found that it was present in 1% of male idiopathic infertility cases. (610441)

MalaCards based summary : Testicular Microlithiasis is related to testicular germ cell tumor and testicular cancer. An important gene associated with Testicular Microlithiasis is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Glucose / Energy Metabolism and Direct p53 effectors. Affiliated tissues include testis, testes and spleen, and related phenotypes are testicular microlithiasis and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Testicular microlithiasis is an unusual condition diagnosed on testicular ultrasound. It is found in... more...

Related Diseases for Testicular Microlithiasis

Diseases related to Testicular Microlithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 30.1 AFP PTEN
2 testicular cancer 10.6
3 germ cells tumors 10.5
4 seminoma 10.4
5 infertility 10.4
6 cryptorchidism, unilateral or bilateral 10.3
7 in situ carcinoma 10.3
8 mccune-albright syndrome 10.2
9 down syndrome 10.2
10 endodermal sinus tumor 10.2
11 mixed germ cell tumor 10.2
12 lipoid congenital adrenal hyperplasia 10.1
13 pseudoxanthoma elasticum 10.1
14 testicular germ cell tumor 1 10.1
15 male infertility 10.1
16 teratocarcinoma 10.1
17 testicular germ cell cancer 10.1
18 precocious puberty 10.1
19 testicular seminoma 10.1
20 epidermoid cysts 10.0
21 lentigines 10.0
22 ruvalcaba syndrome 10.0
23 pulmonary alveolar microlithiasis 10.0
24 adrenal hypoplasia, congenital 10.0
25 fragile x syndrome 10.0
26 ichthyosis, x-linked 10.0
27 beta-thalassemia 10.0
28 thalassemia 10.0
29 fibrous dysplasia 10.0
30 hypogonadotropic hypogonadism 10.0
31 hypospadias 10.0
32 varicocele 10.0
33 ichthyosis 10.0
34 calcinosis 10.0
35 orchitis 10.0
36 cystic teratoma 10.0
37 teratoma 10.0
38 sertoli cell tumor 10.0
39 choriocarcinoma 10.0
40 empty sella syndrome 10.0
41 extragonadal germ cell cancer 10.0
42 adenoma 10.0
43 parathyroid adenoma 10.0
44 epididymo-orchitis 10.0
45 familial tumoral calcinosis 10.0
46 uterine anomalies 9.9 AFP PTEN
47 gastrointestinal system cancer 9.9 AFP PTEN
48 endocrine gland cancer 9.8 AFP PTEN
49 cholangiocarcinoma 9.8 AFP PTEN
50 hypophosphatemic rickets with hypercalciuria, hereditary 9.7 GALNT3 SLC34A2

Graphical network of the top 20 diseases related to Testicular Microlithiasis:



Diseases related to Testicular Microlithiasis

Symptoms & Phenotypes for Testicular Microlithiasis

Human phenotypes related to Testicular Microlithiasis:

33
# Description HPO Frequency HPO Source Accession
1 testicular microlithiasis 33 HP:0012215

Clinical features from OMIM:

610441

GenomeRNAi Phenotypes related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.73 SLC34A2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.73 PTEN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.73 PTEN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.73 PTEN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.73 PTEN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.73 SLC34A2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.73 PTEN SLC34A2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.73 PTEN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.73 PTEN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.73 PTEN SLC34A2
11 Reduced mammosphere formation GR00396-S 8.8 AFP GALNT3 PTEN

MGI Mouse Phenotypes related to Testicular Microlithiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.13 GALNT3 PTEN SLC34A2
2 renal/urinary system MP:0005367 8.8 GALNT3 PTEN SLC34A2

Drugs & Therapeutics for Testicular Microlithiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk Terminated NCT00820287 Not Applicable

Search NIH Clinical Center for Testicular Microlithiasis

Genetic Tests for Testicular Microlithiasis

Genetic tests related to Testicular Microlithiasis:

# Genetic test Affiliating Genes
1 Testicular Microlithiasis 30

Anatomical Context for Testicular Microlithiasis

MalaCards organs/tissues related to Testicular Microlithiasis:

42
Testis, Testes, Spleen, Adrenal Gland, Appendix

Publications for Testicular Microlithiasis

Articles related to Testicular Microlithiasis:

(show top 50) (show all 244)
# Title Authors Year
1
Testicular Cancer in Infertile Men With and Without Testicular Microlithiasis: A Systematic Review and Meta-Analysis of Case-Control Studies. ( 30949131 )
2019
2
Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study. ( 29969051 )
2019
3
Prevalence and risk factors of testicular microlithiasis in patients with hypospadias: a retrospective study. ( 29843681 )
2018
4
A case of Riley Ruvalcaba syndrome with a novel PTEN mutation accompanied by diffuse testicular microlithiasis and precocious puberty. ( 29194042 )
2018
5
Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark. ( 29510806 )
2018
6
Shear wave elastography evaluation in pediatric testicular microlithiasis: a comparative study. ( 29075915 )
2018
7
Adolescent testicular microlithiasis: A case-based, multinational survey of clinical management practices. ( 29428360 )
2018
8
The role of ARFI elastography to evaluate microstructrual changes of patients with testicular microlithiasis. ( 29566548 )
2018
9
Testicular microlithiasis in a clinically healthy cynomolgus monkey (Macaca fascicularis). ( 29750004 )
2018
10
European Society of Paediatric Radiology Abdominal Imaging Task Force recommendations in paediatric uroradiology, part X: how to perform paediatric gastrointestinal ultrasonography, use gadolinium as a contrast agent in children, follow up paediatric testicular microlithiasis, and an update on paediatric contrast-enhanced ultrasound. ( 29796794 )
2018
11
Testicular microlithiasis and testicular tumor: a review of the literature. ( 30002831 )
2018
12
Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis. ( 30027931 )
2018
13
Re: Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population. ( 30227564 )
2018
14
Ultrasound Evaluation of Testicular Volume in Patients with Testicular Microlithiasis. ( 30250943 )
2018
15
Testicular microlithiasis in a boy with X-linked adrenal hypoplasia congenita. ( 30286574 )
2018
16
Testicular microlithiasis: what urologists should know. A review of the current literature. ( 30386652 )
2018
17
Comparison of Tissue Stiffness Using Shear Wave Elastography in Men with Normal Testicular Tissue, Testicular Microlithiasis and Testicular Cancer. ( 29276802 )
2017
18
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. ( 29040905 )
2017
19
Long-Term Follow-Up of Testicular Microlithiasis in Children and Adolescents: Multicenter Prospective Cohort Study of the Italian Society of Pediatric Urology. ( 26962678 )
2017
20
Testicular Microlithiasis in the Setting of Primary Extragonadal Germ Cell Tumor: A Case Series. ( 27599309 )
2017
21
The influence of testicular microlithiasis on the outcomes of in vitro fertilisation in a Chinese Han population. ( 27882628 )
2017
22
Characteristics of symptomatic men with testicular microlithiasis - A Danish cross-sectional questionnaire study. ( 28267895 )
2017
23
Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population. ( 28715257 )
2017
24
Prevalence and Chronological Changes of Testicular Microlithiasis in Isolated Congenital Undescended Testes Operated On at Less Than 3 Years of Age. ( 28780301 )
2017
25
Testicular microlithiasis is associated with ethnicity and socioeconomic status. ( 28815058 )
2017
26
Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia. ( 28835760 )
2017
27
Pediatric Testicular Microlithiasis: To Refer or Not to Refer? ( 29051915 )
2017
28
Role of calcifying nanoparticles in the development of testicular microlithiasis in vivo. ( 29084530 )
2017
29
Testicular microlithiasis and testicular cancer: review of the literature. ( 27007613 )
2016
30
Testicular Microlithiasis: Is Sonographic Surveillance Necessary? Single Centre 14 Year Experience in 442 Patients with Testicular Microlithiasis. ( 25654622 )
2016
31
Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis. ( 26265690 )
2016
32
Inter- and intraobserver agreement in detection of testicular microlithiasis with ultrasonography. ( 26419255 )
2016
33
How should we monitor boys with testicular microlithiasis? ( 27007453 )
2016
34
Testicular Microlithiasis: What Should You Recommend? ( 27058778 )
2016
35
Testicular microlithiasis: Correlation with doppler sonography of testicular arteries and sperm function. ( 27120130 )
2016
36
Re: Ultrasound Demonstration of Testicular Microlithiasis in Pediatric Patients: Is There an Association with Testicular Germ Cell Tumors? ( 27321534 )
2016
37
Testicular microlithiasis and preliminary experience of acoustic radiation force impulse imaging. ( 27504193 )
2016
38
Re: Testicular Microlithiasis Imaging and Follow-up: Guidelines of the ESUR Scrotal Imaging Subcommittee. ( 27597076 )
2016
39
Unilateral testicular microlithiasis: a rare paediatric incidental finding. ( 27613265 )
2016
40
Testicular Microlithiasis: Patient Compliance in a Two-Year Follow-Up Program. ( 27921092 )
2016
41
Incidence of testicular microlithiasis in patients with β-thalassemia major. ( 26251156 )
2015
42
Should patients with Down syndrome be screened for testicular microlithiasis? ( 24705995 )
2015
43
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
44
A Meta-Analysis of the Relationship between Testicular Microlithiasis and Incidence of Testicular Cancer. ( 25923148 )
2015
45
Testicular microlithiasis imaging and follow-up: guidelines of the ESUR scrotal imaging subcommittee. ( 25316054 )
2015
46
A case report of transverse testicular ectopia with testicular microlithiasis. ( 25380032 )
2015
47
Testicular microlithiasis and associated testicular malignancies in childhood: a systematic review. ( 25417839 )
2015
48
Attributable risk calculations for testicular microlithiasis. ( 25502584 )
2015
49
Changes of calcific density in pediatric patients with testicular microlithiasis. ( 25874046 )
2015
50
Coexistence of testicular microlithiasis with parathyroid adenoma in an obese child. ( 24030026 )
2014

Variations for Testicular Microlithiasis

Expression for Testicular Microlithiasis

Search GEO for disease gene expression data for Testicular Microlithiasis.

Pathways for Testicular Microlithiasis

Pathways related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 PTEN SLC34A2
2 10.74 AFP PTEN

GO Terms for Testicular Microlithiasis

Cellular components related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.62 PTEN SLC34A2

Biological processes related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.62 AFP SLC34A2

Sources for Testicular Microlithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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