MCID: TST025
MIFTS: 29

Testicular Microlithiasis

Categories: Reproductive diseases

Aliases & Classifications for Testicular Microlithiasis

MalaCards integrated aliases for Testicular Microlithiasis:

Name: Testicular Microlithiasis 56 29 13 39 71

Classifications:



External Ids:

OMIM 56 610441
MedGen 41 C1864873
SNOMED-CT via HPO 68 117261000119108
UMLS 71 C1864873

Summaries for Testicular Microlithiasis

OMIM : 56 Testicular microlithiasis, the deposition of calcium phosphate microliths within the seminiferous tubules, has a population prevalence of 0.6 to 9% (Kim et al., 2003). Middleton et al. (2002) found that it was associated with a majority of primary testicular malignancies. Miller and Sidhu (2002) found that it was present in 1% of male idiopathic infertility cases. (610441)

MalaCards based summary : Testicular Microlithiasis is related to testicular germ cell tumor and teratoma. An important gene associated with Testicular Microlithiasis is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Direct p53 effectors. Affiliated tissues include testis, testes and spleen, and related phenotypes are testicular microlithiasis and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Testicular microlithiasis is an unusual condition diagnosed on testicular ultrasound. It is found in... more...

Related Diseases for Testicular Microlithiasis

Diseases related to Testicular Microlithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 30.2 PTEN AFP
2 teratoma 30.1 PTEN AFP
3 pulmonary alveolar microlithiasis 29.8 SLC34A2 GALNT3
4 cystic teratoma 29.5 PTEN AFP
5 testicular cancer 10.9
6 cryptorchidism, unilateral or bilateral 10.7
7 infertility 10.7
8 germ cells tumors 10.7
9 varicocele 10.6
10 seminoma 10.6
11 in situ carcinoma 10.6
12 male infertility 10.5
13 testicular germ cell cancer 10.5
14 testicular torsion 10.5
15 mixed germ cell tumor 10.4
16 hypogonadotropic hypogonadism 10.4
17 hydrocele 10.4
18 mccune-albright syndrome 10.4
19 endodermal sinus tumor 10.4
20 hypogonadism 10.4
21 hypogonadotropism 10.4
22 precocious puberty 10.4
23 down syndrome 10.3
24 testicular disease 10.3
25 germ cell cancer 10.3
26 testicular yolk sac tumor 10.3
27 lipoid congenital adrenal hyperplasia 10.2
28 orchitis 10.2
29 peutz-jeghers syndrome 10.2
30 pseudoxanthoma elasticum 10.2
31 gonadoblastoma 10.2
32 thalassemia 10.2
33 azoospermia 10.2
34 teratocarcinoma 10.2
35 embryonal carcinoma 10.2
36 sertoli cell tumor 10.2
37 choriocarcinoma 10.2
38 extragonadal germ cell cancer 10.2
39 mature teratoma 10.2
40 epididymo-orchitis 10.2
41 testicular seminoma 10.2
42 autoimmune disease 10.0
43 epidermoid cysts 10.0
44 lentigines 10.0
45 neurofibromatosis, type iv, of riccardi 10.0
46 ruvalcaba syndrome 10.0
47 tumoral calcinosis, hyperphosphatemic, familial, 1 10.0
48 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
49 adrenal hypoplasia, congenital 10.0
50 fragile x syndrome 10.0

Graphical network of the top 20 diseases related to Testicular Microlithiasis:



Diseases related to Testicular Microlithiasis

Symptoms & Phenotypes for Testicular Microlithiasis

Human phenotypes related to Testicular Microlithiasis:

31
# Description HPO Frequency HPO Source Accession
1 testicular microlithiasis 31 HP:0012215

Clinical features from OMIM:

610441

GenomeRNAi Phenotypes related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.8 SLC34A2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.8 PTEN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.8 PTEN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.8 PTEN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.8 PTEN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.8 SLC34A2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.8 SLC34A2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.8 PTEN SLC34A2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.8 SLC34A2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.8 PTEN
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 PTEN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.8 PTEN SLC34A2
13 Reduced mammosphere formation GR00396-S 8.8 AFP GALNT3 PTEN

MGI Mouse Phenotypes related to Testicular Microlithiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.13 GALNT3 PTEN SLC34A2
2 renal/urinary system MP:0005367 8.8 GALNT3 PTEN SLC34A2

Drugs & Therapeutics for Testicular Microlithiasis

Search Clinical Trials , NIH Clinical Center for Testicular Microlithiasis

Genetic Tests for Testicular Microlithiasis

Genetic tests related to Testicular Microlithiasis:

# Genetic test Affiliating Genes
1 Testicular Microlithiasis 29

Anatomical Context for Testicular Microlithiasis

MalaCards organs/tissues related to Testicular Microlithiasis:

40
Testis, Testes, Spleen, Adrenal Gland, Appendix

Publications for Testicular Microlithiasis

Articles related to Testicular Microlithiasis:

(show top 50) (show all 350)
# Title Authors PMID Year
1
Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives. 61 56
18841155 2008
2
Testicular microlithiasis as a familial risk factor for testicular germ cell tumour. 56 61
17971766 2007
3
Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. 56 61
16960801 2006
4
Testicular microlithiasis: clinical significance and review of the literature. 61 56
14531010 2003
5
Does testicular microlithiasis matter? A review. 56 61
12413911 2002
6
Testicular microlithiasis: prospective analysis of prevalence and associated tumor. 61 56
12147838 2002
7
Incidence characteristics of testicular microlithiasis and its association with risk of primary testicular tumors in children: a systematic review and meta-analysis. 61
31853884 2019
8
Association between risk factors and testicular microlithiasis. 61
31588363 2019
9
Testicular microlithiasis: Systematic review and Clinical guidelines. 61
31383508 2019
10
[Relationship between testicular microcalcifications and clinical characteristics in patients with testicular cancer]. 61
31383611 2019
11
Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study. 61
29969051 2019
12
Testicular Cancer in Infertile Men With and Without Testicular Microlithiasis: A Systematic Review and Meta-Analysis of Case-Control Studies. 61
30949131 2019
13
The role of ARFI elastography to evaluate microstructrual changes of patients with testicular microlithiasis. 61
29566548 2018
14
[Testicular Microlithiasis: Update on diagnosis and management.] 61
30560797 2018
15
Is Testicular Macrocalcification a Risk for Malignancy?: Tumor Development on Ultrasonographic Follow-up of Preexisting Intratesticular Macrocalcification. 61
29665033 2018
16
Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis. 61
30027931 2018
17
Re: Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population. 61
30227564 2018
18
Ultrasound Evaluation of Testicular Volume in Patients with Testicular Microlithiasis. 61
30250943 2018
19
Testicular microlithiasis in a boy with X-linked adrenal hypoplasia congenita. 61
30286574 2018
20
European Society of Paediatric Radiology Abdominal Imaging Task Force recommendations in paediatric uroradiology, part X: how to perform paediatric gastrointestinal ultrasonography, use gadolinium as a contrast agent in children, follow up paediatric testicular microlithiasis, and an update on paediatric contrast-enhanced ultrasound. 61
29796794 2018
21
The role of electrocardiogram in sex verification in a young adult with primary amenorrhea: a case report. 61
30220253 2018
22
Fertility preservation in testicular cancer - predictors of spermatogenesis. 61
29667332 2018
23
Scrotal ultrasonographic findings in obese infertile patients and their correlations to semen and hormonal profile. 61
30183611 2018
24
[Pathologic features on gonadal changes of sexual developmental disorders in children]. 61
29996319 2018
25
Prevalence, clinical characteristics and long-term outcomes of classical 11 β-hydroxylase deficiency (11BOHD) in Turkish population and novel mutations in CYP11B1 gene. 61
29626607 2018
26
Prevalence and risk factors of testicular microlithiasis in patients with hypospadias: a retrospective study. 61
29843681 2018
27
Shear wave elastography evaluation in pediatric testicular microlithiasis: a comparative study. 61
29075915 2018
28
Adolescent testicular microlithiasis: A case-based, multinational survey of clinical management practices. 61
29428360 2018
29
Testicular microlithiasis in a clinically healthy cynomolgus monkey (Macaca fascicularis). 61
29750004 2018
30
Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark. 61
29510806 2018
31
Hyperphosphatemic Familial Tumoral Calcinosis 61
29389098 2018
32
A case of Riley Ruvalcaba syndrome with a novel PTEN mutation accompanied by diffuse testicular microlithiasis and precocious puberty. 61
29194042 2018
33
Testicular microlithiasis and testicular tumor: a review of the literature. 61
30002831 2018
34
Testicular microlithiasis: what urologists should know. A review of the current literature. 61
30386652 2018
35
Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population. 61
28715257 2017
36
Prevalence and Chronological Changes of Testicular Microlithiasis in Isolated Congenital Undescended Testes Operated On at Less Than 3 Years of Age. 61
28780301 2017
37
The influence of testicular microlithiasis on the outcomes of in vitro fertilisation in a Chinese Han population. 61
27882628 2017
38
Role of calcifying nanoparticles in the development of testicular microlithiasis in vivo. 61
29084530 2017
39
Comparison of Tissue Stiffness Using Shear Wave Elastography in Men with Normal Testicular Tissue, Testicular Microlithiasis and Testicular Cancer. 61
29276802 2017
40
Testicular microlithiasis is associated with ethnicity and socioeconomic status. 61
28815058 2017
41
[Advances in the studies of testicular microlithiasis]. 61
29726650 2017
42
Pediatric scrotal ultrasound: review and update. 61
28779199 2017
43
Characteristics of symptomatic men with testicular microlithiasis - A Danish cross-sectional questionnaire study. 61
28267895 2017
44
Long-Term Follow-Up of Testicular Microlithiasis in Children and Adolescents: Multicenter Prospective Cohort Study of the Italian Society of Pediatric Urology. 61
26962678 2017
45
Testicular Microlithiasis in the Setting of Primary Extragonadal Germ Cell Tumor: A Case Series. 61
27599309 2017
46
Prevalence of small testicular hyperechogenic foci in subgroups of 382 non-vasectomized, azoospermic men: a retrospective cohort study. 61
28061524 2017
47
Bilateral methachronous testicular germ cell tumor and testicular microlithiasis in a child: Genetic analysis and insights. A case report. 61
29040905 2017
48
Sonography and Magnetic Resonance Imaging Characteristics of Testicular Adrenal Rest Tumors. 61
29662589 2017
49
Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia. 61
28835760 2017
50
Pediatric Testicular Microlithiasis: To Refer or Not to Refer? 61
29051915 2017

Variations for Testicular Microlithiasis

Expression for Testicular Microlithiasis

Search GEO for disease gene expression data for Testicular Microlithiasis.

Pathways for Testicular Microlithiasis

Pathways related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.74 PTEN AFP

GO Terms for Testicular Microlithiasis

Biological processes related to Testicular Microlithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.62 SLC34A2 AFP

Sources for Testicular Microlithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....