MCID: TST043
MIFTS: 40

Testicular Seminoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Seminoma

MalaCards integrated aliases for Testicular Seminoma:

Name: Testicular Seminoma 54 17
Testicular Seminomatous Germ Cell Tumor 54
Seminomatous Germ Cell Tumor of Testis 54
Seminoma of Testis 54
Seminoma 74

Classifications:



External Ids:

UMLS 74 C0036631

Summaries for Testicular Seminoma

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 842Disease definitionTesticular seminomatous germ celltumor is a rare testicular germ cell tumor (see this term), most commonly presenting with a painless mass in the scrotum, with a very high cure rate if caught in the early stages.EpidemiologyAnnual incidence in Europe is 1/62,000 people. It accounts for 40% of testicular cancer cases.Clinical descriptionSeminoma usually presents in males between the ages of 30-40. A painless mass in the scrotum is indicative of disease. A long-standing hydrocele may be noted causing a feeling of heaviness in the testicle. Gynecomastia and back and flank pain are symptoms that are seen in some patients. Relapse after surgery can occur, usually (in 97% of cases) in the high iliac or retroperitoneal lymph nodes. Metastasis, although rare, can occur in some cases, affecting the lungs, liver, bones and central nervous system.EtiologyEtiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). Cryptorchidism is a risk factor for the development of testicular seminomatous germ cell tumors.Diagnostic methodsUltrasound usually confirms the presence of a testicular mass. Measurement of tumor markers in blood such as alpha-fetoprotein (AFP), beta human chorionic gonadotropin (BHC) and lactate dehydrogenase (LDH) is needed as it can be useful in cases where the tumor is still very small. Classical seminoma does not secrete AFP and patients with raised levels of this tumor marker are given a diagnosis of non-seminoma. After surgical removal of testicle, histopathological characteristics are analyzed and a stage can be assigned. In stage 1 disease the primary tumor is limited to the testis and epididymus with possible invasion of the tunica albuginea, tunica vaginalis, spermatic cord and scrotum but no lymph node or distant metastasis. Stage 2 (2A, 2B and 2C) disease features regional lymph node metastasis and stage 3 has distant metastasis of varying degrees.Differential diagnosisTesticular non seminomatous germ cell tumors (see this term) must be excluded.Management and treatmentTreatment for stage 1 seminoma involves an orchiectomy or partial orchiectomy in some cases. Most patients (88%) do not require any further treatment and only surveillance is necessary. In those cases where follow up is difficult, adjuvant carboplatin or radiotherapy can be applied. Para-aortic and ipsilateral iliac radiotherapy (30 Gy in 2 Gy fractions) is the standard treatment of stage 2A seminoma. Cisplatin, etoposide and bleomycin (PEB) chemotherapy (three cycles) or cisplatin and etoposide (PE) chemotherapy (4 cycles) is an alternative to radiotherapy (but has more acute toxicity). Those with stage 2B, 2C and stage 3 seminomas are given PEB chemotherapy (three or four cycles depending on prognosis). In those with a reduced lung capacity or with emphysema or in severe smokers, 4 cycles of PE is preferred over PEB. Ifosfamide is given instead of bleomycin in certain cases (i.e. patients with existing lung damage). Follow up and sometimes a PET scan is recommended to monitor for residual lesions. Due to cosmetic and psychological reasons, patients may be offered testicular prostheses after an orchidectomy.PrognosisPrognosis is good but depends on the stage of disease with 5- year survival rates as high as 99% in stage 1 disease. Relapse rates at 5 years depend on risk factors (ex. invasion of the rete testis, tumor size >4cm) present, but is only 12% in those with no risk factors.Visit the Orphanet disease page for more resources.

MalaCards based summary : Testicular Seminoma, also known as testicular seminomatous germ cell tumor, is related to testicular germ cell tumor and seminoma. An important gene associated with Testicular Seminoma is TSPY1 (Testis Specific Protein Y-Linked 1), and among its related pathways/superpathways are Peptide hormone metabolism and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Granisetron and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and bone marrow.

Related Diseases for Testicular Seminoma

Diseases related to Testicular Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 32.1 AFP CGB3
2 seminoma 31.0 AFP CGA CGB3 TSPY1
3 germ cell cancer 29.8 AFP CGA
4 endodermal sinus tumor 29.8 AFP CGB3
5 teratoma 29.7 AFP CGA CGB3
6 choriocarcinoma 29.5 CGA CGB3
7 testicular cancer 29.2 AFP CGA CGB3 TSPY1
8 tubular variant testicular seminoma 12.3
9 cribriform variant testicular seminoma 12.3
10 pseudoglandular variant testicular seminoma 12.3
11 testis seminoma 11.3
12 sarcoma 10.3
13 germinoma 10.3
14 nonseminomatous germ cell tumor 10.2
15 cryptorchidism, unilateral or bilateral 10.2
16 persistent mullerian duct syndrome 10.2
17 pineal region germinoma 10.2
18 testicular microlithiasis 10.1
19 leukemia 10.1
20 infant gynecomastia 10.1
21 gynecomastia 10.1
22 germ cells tumors 10.1
23 hydatidiform mole, recurrent, 1 10.0 CGA CGB3
24 ovarian mixed germ cell neoplasm 10.0 AFP CGA
25 polyembryoma 10.0 AFP CGA
26 sacrococcygeal teratoma 10.0 AFP CGA
27 triploidy 10.0 AFP CGA
28 tuberculous epididymitis 10.0 AFP CGB3
29 turner syndrome 9.9 CGB3 TSPY1
30 ectopic pregnancy 9.9 CGA CGB3
31 orofaciodigital syndrome viii 9.9 AFP CGA
32 dysgerminoma 9.9 AFP TSPY1
33 hydrocele 9.9 AFP CGA
34 spinal cord injury 9.9
35 orchitis 9.9
36 ureteral obstruction 9.9
37 prune belly syndrome 9.9
38 renal cell carcinoma, nonpapillary 9.9
39 precocious puberty, male-limited 9.9
40 retinoblastoma 9.9
41 thyroid cancer, nonmedullary, 1 9.9
42 adrenocortical carcinoma, hereditary 9.9
43 ataxia-telangiectasia 9.9
44 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
45 fanconi anemia, complementation group d2 9.9
46 thymoma, familial 9.9
47 testicular germ cell tumor 1 9.9
48 gonadoblastoma 9.9
49 leukemia, chronic myeloid 9.9
50 myocardial infarction 9.9

Graphical network of the top 20 diseases related to Testicular Seminoma:



Diseases related to Testicular Seminoma

Symptoms & Phenotypes for Testicular Seminoma

Drugs & Therapeutics for Testicular Seminoma

Drugs for Testicular Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
3
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
5
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
6
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
7
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
8
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
9
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 1177-87-3
12
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
13
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
14
Captopril Approved Phase 3 62571-86-2 44093
15
Ribavirin Approved Phase 3 36791-04-5 37542
16
Palivizumab Approved, Investigational Phase 3 188039-54-5
17
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
18
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
19
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
20
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
21
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
22
Ondansetron Approved Phase 3 99614-02-5 4595
23
Promethazine Approved, Investigational Phase 3 60-87-7 4927
24
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
25
Vinblastine Approved Phase 3 865-21-4 241903 13342
26 Serotonin Antagonists Phase 3
27 Antiemetics Phase 3,Phase 2
28 Serotonin Agents Phase 3
29 Neurotransmitter Agents Phase 3
30 Gastrointestinal Agents Phase 3,Phase 2
31 Autonomic Agents Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 3,Phase 2
33 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
34 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
35 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
36 Etoposide phosphate Phase 2, Phase 3,Phase 3
37 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
38 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
39 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
40 Immunologic Factors Phase 3,Phase 1,Phase 2
41 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
42 Alkylating Agents Phase 3,Phase 1,Phase 2
43 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
44 Antiviral Agents Phase 3,Phase 1,Phase 2
45 Anti-Infective Agents Phase 3,Phase 1,Phase 2
46 Antimetabolites Phase 3,Phase 1,Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
48 Hormone Antagonists Phase 3,Phase 2,Phase 1
49 Hormones Phase 3,Phase 2,Phase 1
50
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
2 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
5 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
7 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
8 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
10 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
12 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
13 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
14 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
16 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
17 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
18 Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma Completed NCT02272816 Phase 2 Carboplatin AUC-10
19 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
20 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
21 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
22 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
23 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
24 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
25 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
26 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
27 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
28 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
29 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
30 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
31 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
32 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
33 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
34 Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
35 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
36 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
37 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
38 Therapy De-escalation in Seminoma Stage IIA/B Active, not recruiting NCT01593241 Phase 2 Carboplatin
39 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Active, not recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
40 Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma Not yet recruiting NCT03937843 Phase 2 Carboplatin;Cisplatin;Etoposide
41 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
42 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
43 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
44 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
45 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
46 Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle Unknown status NCT02873793
47 REtrospective Study of TESTIcular CAncer Patients at the University Magdeburg Completed NCT02092740
48 Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients Completed NCT00705094
49 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
50 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable

Search NIH Clinical Center for Testicular Seminoma

Genetic Tests for Testicular Seminoma

Anatomical Context for Testicular Seminoma

MalaCards organs/tissues related to Testicular Seminoma:

42
Testis, Lymph Node, Bone Marrow, Lung, Colon, Thyroid, Myeloid

Publications for Testicular Seminoma

Articles related to Testicular Seminoma:

(show top 50) (show all 451)
# Title Authors Year
1
Testicular Seminoma in a Transgender Woman: A Case Report. ( 30650051 )
2019
2
Re: Exploring the Spectrum of Late Effects following Radical Orchidectomy for Stage I Testicular Seminoma: . ( 30759675 )
2019
3
Prominent right ventricular mass in a young patient with a history of classic testicular seminoma: a case report. ( 31020243 )
2019
4
Synthesis of a novel platinum(II) complex with 6,7-dichloro-5,8-quinolinedione and the study of its antitumor mechanism in testicular seminoma. ( 31055215 )
2019
5
PET-CT for the management of testicular seminoma patients with post-chemotherapy residual masses. ( 31075095 )
2019
6
Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature. ( 30350189 )
2019
7
Ambiguous presentation of an intra-abdominal testicular seminoma in a 40-year-old man: a case report. ( 30609931 )
2019
8
Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth. ( 30610844 )
2019
9
Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma. ( 29955031 )
2018
10
Persistent Mullerian Duct Syndrome with Testicular Seminoma in Transverse Testicular Ectopia. ( 30568363 )
2018
11
Testicular seminoma: Scattered radiation dose to the contralateral testis in the modern era. ( 29306641 )
2018
12
On thin ice: barriers to adoption of surveillance for patients with stage I testicular seminoma. Survey of US radiation oncologists. ( 29522295 )
2018
13
Bilateral synchronous testicular seminoma: A rare presentation of a rare disease. ( 29633802 )
2018
14
Superior vena cava obstruction by metastatic mediastinal testicular seminoma. Imaging of collateral pathways during gastrointestinal bleeding scintigraphy with 99mTc labeled red blood cells. ( 29636233 )
2018
15
Prognostic factors for relapse in stage I testicular seminoma: tumor size and rete testis invasion revisited. ( 29744734 )
2018
16
Metachronous Testicular Seminoma After Testicular Tumor. ( 30145557 )
2018
17
Testicular seminoma in the aged rat visualized by phase-contrast X-ray computed tomography. ( 30377541 )
2018
18
Colon Obstruction as an Isolated Late Gastrointestinal Metastasis of Testicular Seminoma. ( 27678015 )
2018
19
Patterns of care and survival outcomes for adolescent and young adult patients with testicular seminoma in the United States: A National Cancer Database analysis. ( 28153774 )
2017
20
Testicular Seminoma. ( 28160884 )
2017
21
Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy. ( 28367345 )
2017
22
Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives. ( 28574809 )
2017
23
Pure Testicular Seminoma with Non-Pathologic Elevation of Alpha Fetoprotein: A Case Series. ( 28668957 )
2017
24
Re: Testicular Seminoma Clinical Stage 1: Treatment Outcome on a Routine Care Level. ( 28817914 )
2017
25
Appendix 9: Testicular seminoma and non-seminoma: eUpdate published online 29 June 2017 (www.esmo.org/Guidelines/Genitourinary-Cancers). ( 28881930 )
2017
26
Testicular seminoma: oncologic rationale and role of surgery in treatment. ( 28949942 )
2017
27
Testicular seminoma: Are clinical features and treatment outcomes any different in India? ( 29199728 )
2017
28
Isolated metastasis of testicular seminoma to extralobar pulmonary sequestration. ( 26744493 )
2016
29
Diffuse type testicular seminoma in a stallion. ( 27818621 )
2016
30
Differences in global DNA methylation of testicular seminoma are not associated with changes in histone modifications, clinical prognosis, BRAF mutations or gene expression. ( 27886677 )
2016
31
Testicular Seminoma Occurring After Kidney Transplantation in a Patient Previously Treated for Teratoma: De Novo Malignancy or Recurrence in a Different Histologic Form? ( 27932163 )
2016
32
The diagnostic yield of fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography in recurrent testicular seminoma. ( 28058002 )
2016
33
mTOR expression in human testicular seminoma. ( 26648340 )
2016
34
Treatment Trends for Stage I Testicular Seminoma in an Equal-Access Medical System. ( 26794393 )
2016
35
Re: Management Trends in Stage I Testicular Seminoma: Impact of Race, Insurance Status, and Treatment Facility. ( 26852980 )
2016
36
TDRG1 functions in testicular seminoma are dependent on the PI3K/Akt/mTOR signaling pathway. ( 26855590 )
2016
37
Analysis of the prognosis of patients with testicular seminoma. ( 26893743 )
2016
38
Testicular seminoma clinical stage 1: treatment outcome on a routine care level. ( 27116691 )
2016
39
Controversies in the management of clinical stage I testicular seminoma. ( 27123323 )
2016
40
Stage II Testicular Seminoma: Patterns of Care and Survival by Treatment Strategy. ( 27146264 )
2016
41
Metachronous testicular seminoma after radiotherapy and chemotherapy: a case report. ( 27184033 )
2016
42
Coexistence of 2 malignant urogenital neoplasms: a testicular seminoma and adenocarcinoma of the prostate gland in a patient 1 year after kidney transplantation. ( 27243345 )
2016
43
Testicular Seminoma With Pseudocyst and Coagulation Necrosis Like Burned-out Tumor: A Case Report. ( 27335779 )
2016
44
Clinical Characteristics and Outcomes of Late Relapse in Stage I Testicular Seminoma. ( 27339401 )
2016
45
Testicular seminoma metastasis to duodenum. Misdiagnosed as primary duodenal tumor. ( 27372029 )
2016
46
Long-term outcomes following post-operative radiotherapy for Stage I/II testicular seminoma - an Australasian single-institution experience. ( 27648280 )
2016
47
A case of testicular seminoma in persistent Mullerian duct syndrome with transverse testicular ectopia. ( 25504517 )
2015
48
Adjuvant radiotherapy outcome of stage I testicular seminoma: a single institution study. ( 25510743 )
2015
49
Intestinal metastases as an unusual presentation of a burned-out testicular seminoma: PET/CT imaging. ( 25558783 )
2015
50
Treatment preferences in stage IA and IB testicular seminoma: multicenter study of Anatolian Society of Medical Oncology. ( 25605506 )
2015

Variations for Testicular Seminoma

Expression for Testicular Seminoma

Search GEO for disease gene expression data for Testicular Seminoma.

GO Terms for Testicular Seminoma

Cellular components related to Testicular Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 AFP CGA CGB3 CLU
2 extracellular space GO:0005615 8.92 AFP CGA CGB3 CLU

Biological processes related to Testicular Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone processing GO:0016486 8.62 CGA CGB3

Molecular functions related to Testicular Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CGA CGB3

Sources for Testicular Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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