MCID: TST043
MIFTS: 31

Testicular Seminoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Seminoma

MalaCards integrated aliases for Testicular Seminoma:

Name: Testicular Seminoma 20 17
Testicular Seminomatous Germ Cell Tumor 20
Seminomatous Germ Cell Tumor of Testis 20
Seminoma of Testis 20
Seminoma 70

Classifications:



External Ids:

UMLS 70 C0036631

Summaries for Testicular Seminoma

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 842 Definition Testicular seminomatous germ cell tumor is a rare testicular germ cell tumor (see this term), most commonly presenting with a painless mass in the scrotum, with a very high cure rate if caught in the early stages. Epidemiology Annual incidence in Europe is 1/62,000 people. It accounts for 40% of testicular cancer cases. Clinical description Seminoma usually presents in males between the ages of 30-40. A painless mass in the scrotum is indicative of disease. A long-standing hydrocele may be noted causing a feeling of heaviness in the testicle. Gynecomastia and back and flank pain are symptoms that are seen in some patients. Relapse after surgery can occur, usually (in 97% of cases) in the high iliac or retroperitoneal lymph nodes. Metastasis, although rare, can occur in some cases, affecting the lungs, liver, bones and central nervous system. Etiology Etiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). Cryptorchidism is a risk factor for the development of testicular seminomatous germ cell tumors. Diagnostic methods Ultrasound usually confirms the presence of a testicular mass. Measurement of tumor markers in blood such as alpha-fetoprotein (AFP), beta human chorionic gonadotropin (BHC) and lactate dehydrogenase (LDH) is needed as it can be useful in cases where the tumor is still very small. Classical seminoma does not secrete AFP and patients with raised levels of this tumor marker are given a diagnosis of non-seminoma. After surgical removal of testicle, histopathological characteristics are analyzed and a stage can be assigned. In stage 1 disease the primary tumor is limited to the testis and epididymus with possible invasion of the tunica albuginea, tunica vaginalis, spermatic cord and scrotum but no lymph node or distant metastasis. Stage 2 (2A, 2B and 2C) disease features regional lymph node metastasis and stage 3 has distant metastasis of varying degrees. Differential diagnosis Testicular non seminomatous germ cell tumors (see this term) must be excluded. Management and treatment Treatment for stage 1 seminoma involves an orchiectomy or partial orchiectomy in some cases. Most patients (88%) do not require any further treatment and only surveillance is necessary. In those cases where follow up is difficult, adjuvant carboplatin or radiotherapy can be applied. Para-aortic and ipsilateral iliac radiotherapy (30 Gy in 2 Gy fractions) is the standard treatment of stage 2A seminoma. Cisplatin, etoposide and bleomycin (PEB) chemotherapy (three cycles) or cisplatin and etoposide (PE) chemotherapy (4 cycles) is an alternative to radiotherapy (but has more acute toxicity). Those with stage 2B, 2C and stage 3 seminomas are given PEB chemotherapy (three or four cycles depending on prognosis ). In those with a reduced lung capacity or with emphysema or in severe smokers, 4 cycles of PE is preferred over PEB. Ifosfamide is given instead of bleomycin in certain cases (i.e. patients with existing lung damage). Follow up and sometimes a PET scan is recommended to monitor for residual lesions. Due to cosmetic and psychological reasons, patients may be offered testicular prostheses after an orchidectomy. Prognosis Prognosis is good but depends on the stage of disease with 5- year survival rates as high as 99% in stage 1 disease. Relapse rates at 5 years depend on risk factors (ex. invasion of the rete testis, tumor size >4cm) present, but is only 12% in those with no risk factors.

MalaCards based summary : Testicular Seminoma, also known as testicular seminomatous germ cell tumor, is related to seminoma and testicular cancer. An important gene associated with Testicular Seminoma is TSPY1 (Testis Specific Protein Y-Linked 1). The drugs Granisetron and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and lung.

Related Diseases for Testicular Seminoma

Diseases related to Testicular Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 seminoma 31.4 TSPY1 CGB3 AFP
2 testicular cancer 30.5 CGB3 AFP
3 germinoma 30.2 CGB3 AFP
4 teratoma 30.2 CGB3 AFP
5 endodermal sinus tumor 30.0 CGB3 AFP
6 embryonal carcinoma 29.9 CGB3 AFP
7 gonadoblastoma 29.7 TSPY1 CGB3
8 chromosomal triplication 29.7 CGB3 AFP
9 tubular variant testicular seminoma 11.3
10 cribriform variant testicular seminoma 11.3
11 pseudoglandular variant testicular seminoma 11.3
12 testicular germ cell tumor 11.2
13 testis seminoma 11.2
14 germ cells tumors 10.6
15 cryptorchidism, unilateral or bilateral 10.4
16 germ cell cancer 10.4
17 spermatocytoma 10.3
18 testicular spermatocytic seminoma 10.3
19 peptic ulcer disease 10.3
20 mature teratoma 10.2
21 infertility 10.2
22 testicular germ cell cancer 10.2
23 in situ carcinoma 10.2
24 sarcoidosis 1 10.2
25 testicular torsion 10.2
26 persistent mullerian duct syndrome 10.2
27 hydronephrosis 10.2
28 sarcoma 10.2
29 spindle cell sarcoma 10.2
30 pineal region germinoma 10.2
31 thyroid carcinoma 10.2
32 thymoma, familial 10.1
33 infant gynecomastia 10.1
34 gynecomastia 10.1
35 azoospermia 10.1
36 hypogonadism 10.1
37 thymoma 10.1
38 choriocarcinoma 10.1
39 pseudohermaphroditism 10.1
40 pulmonary fibrosis 10.1
41 neuropathy 10.1
42 nonseminomatous germ cell tumor 10.1
43 esophageal cancer 10.0
44 renal cell carcinoma, nonpapillary 10.0
45 kaposi sarcoma 10.0
46 testicular microlithiasis 10.0
47 lung cancer susceptibility 3 10.0
48 angiosarcoma 10.0
49 male infertility 10.0
50 thrombocytopenia 10.0

Graphical network of the top 20 diseases related to Testicular Seminoma:



Diseases related to Testicular Seminoma

Symptoms & Phenotypes for Testicular Seminoma

Drugs & Therapeutics for Testicular Seminoma

Drugs for Testicular Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Ondansetron Approved Phase 3 99614-02-5 4595
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
6
Mesna Approved, Investigational Phase 3 3375-50-6 598
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
8
Lenograstim Approved, Investigational Phase 3 135968-09-1
9
Etoposide Approved Phase 3 33419-42-0 36462
10
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
11
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
14
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
15
Ifosfamide Approved Phase 3 3778-73-2 3690
16
Vinblastine Approved Phase 3 865-21-4 13342 241903
17 Antiemetics Phase 3
18 Gastrointestinal Agents Phase 3
19 Neurotransmitter Agents Phase 3
20 Antirheumatic Agents Phase 3
21 Cola Phase 3
22 Psychotropic Drugs Phase 3
23 Hormones Phase 3
24 Liver Extracts Phase 3
25 glucocorticoids Phase 3
26 Hormone Antagonists Phase 3
27 Antineoplastic Agents, Hormonal Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Antipsychotic Agents Phase 3
30 Anti-Anxiety Agents Phase 3
31 Adjuvants, Immunologic Phase 3
32 Immunologic Factors Phase 3
33 Etoposide phosphate Phase 3
34 Antibiotics, Antitubercular Phase 3
35 Anti-Bacterial Agents Phase 3
36 Dermatologic Agents Phase 3
37 Histamine H2 Antagonists Phase 3
38 Podophyllotoxin Phase 3 518-28-5
39 Keratolytic Agents Phase 3
40 Tubulin Modulators Phase 3
41
Isophosphamide mustard Phase 3 100427
42 Alkylating Agents Phase 3
43 Antimitotic Agents Phase 3
44 Albumin-Bound Paclitaxel Phase 3
45
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
46
Ranitidine Approved, Withdrawn Phase 1, Phase 2 66357-59-3, 66357-35-5, 82530-72-1 3001055
47
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
48
Chlorpheniramine Approved Phase 1, Phase 2 113-92-8, 132-22-9 2725
49
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
50
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
2 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
5 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 A Randomized Phase III Double-Blind Study Of Ondansetron And Dexamethasone Versus Ondansetron And Placebo In The Prophylaxis Of Radiation-Induced Emesis Completed NCT00016380 Phase 3 dexamethasone;ondansetron
7 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
8 A Randomized Phase III Study Comparing One Course of Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) and One Course of Carboplatin AUC7 in Clinical Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
9 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
10 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
11 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
12 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
13 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
14 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
15 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
16 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
17 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
18 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
19 A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
20 A Multi-Centre Phase II Study Using Carboplatin AUC-10 for Metastatic Seminoma With IGCCCG Good Prognosis Disease-Therapy Directed by Initial Metabolic Response on PET-CT Completed NCT02272816 Phase 2 Carboplatin AUC-10
21 A Prospective,Multicenter, Phase II Study to Evaluate the Contribution of the Imaging TEP to the Expression of intégrines αvβ3 for the Characterization of the Residual Masses of Non-seminoma Tumors at the End of Chemotherapy Completed NCT02317393 Phase 2
22 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
23 Therapeutic Strategy Guided by PET-TDM for Patients With Grade I or Metastatic Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
24 Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma. A Multicenter, Open Label Phase II Trial With Two Cohorts Recruiting NCT03937843 Phase 2 Carboplatin;Cisplatin;Etoposide
25 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
26 A Single-arm, Phase II Study of Durvalumab (MEDI4736) and Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Active, not recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 Carboplatin Chemotherapy and Involved Node Radiotherapy in Stage IIA/B Seminoma Active, not recruiting NCT01593241 Phase 2 Carboplatin
29 Multicenter Phase 2 Trial of ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Terminated NCT01055067 Phase 2 Tivantinib (ARQ 197)
30 A Phase II Study Of Imatinib Mesylate (Gleevec, Formerly Known As STI571; IND 61,135, NSC #716051) In Patients With Refractory Seminoma Terminated NCT00042952 Phase 2 imatinib mesylate
31 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
32 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
33 Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours: Potential Risks and Consequences for the Conceptus Unknown status NCT03262207
34 A Phase II Study of Adjuvant Proton Radiation Therapy for the Treatment of Stage I, IIA and IIB Seminoma Completed NCT01557790
35 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
36 Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients Completed NCT00705094
37 A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors Recruiting NCT04435756
38 Surgery in Early Metastatic Seminoma (SEMS): Phase II Trial of Retroperitoneal Lymph Node Dissection as First-Line Treatment for Testicular Seminoma With Isolated Retroperitoneal Disease (1-3cm) Active, not recruiting NCT02537548

Search NIH Clinical Center for Testicular Seminoma

Genetic Tests for Testicular Seminoma

Anatomical Context for Testicular Seminoma

MalaCards organs/tissues related to Testicular Seminoma:

40
Testis, Lymph Node, Lung, Pineal, Myeloid, Colon, Thyroid

Publications for Testicular Seminoma

Articles related to Testicular Seminoma:

(show top 50) (show all 897)
# Title Authors PMID Year
1
Testicular seminoma with pagetoid spread into the vas deferens: A rare histopathological presentation. 61
33792962 2021
2
Retroperitoneal extension of massive ulcerated testicular seminoma through the inguinal canal: A case report. 61
33754611 2021
3
Ruptured intra-abdominal testicular seminoma with hemorrhage shock, after inadequate surgical exploration for undescended testis: a case report. 61
33683491 2021
4
Does Testicular Seminoma Involve a Higher Predisposition Than Nonseminoma to Develop Contralateral Testicular Tumors? 61
33724872 2021
5
Seminoma Retroperitoneal Relapse 23 Years After Surgery. 61
33606194 2021
6
Paraneoplastic Progressive Downbeat Nystagmus, Ataxia and Sensorineural Hearing Loss due to the ANTI-Kelch-11 Protein Antibody. 61
33630775 2021
7
[Myocardial infarction in a young patient with seminoma during chemotherapy with cisplatinum, etoposide, and bleomycin]. 61
30064153 2021
8
Clinical utility of the AJCC 8th edition pT1 subclassification and impact on practice patterns in stage I seminoma. 61
33353868 2021
9
Acute dysautonomia and erythromelalgia associated with testicular seminoma: A case report. 61
32631673 2021
10
Stage I testicular seminoma risk-adapted therapeutic management. 61
33502887 2021
11
Re: Identification of Potential Core Genes and MiRNAs in Testicular Seminoma via Bioinformatics Analysis. 61
32897137 2020
12
Unusual case of classic testicular seminoma in a 90-year-old patient: a case report. 61
33032642 2020
13
Escalation of an Otherwise Curable Cancer: Retroperitoneal Mass Destruction Associated With Testicular Seminoma in a Psychiatric Patient. 61
33194491 2020
14
Two cycles of adjuvant carboplatin for clinical stage 1 testicular seminoma in New Zealand centres: A retrospective analysis of efficacy and long-term events. 61
33103860 2020
15
Testicular seminoma with a progressing pulmonary nodule and mediastinal lymphadenopathy without retroperitoneal metastasis. 61
32914079 2020
16
Rare Presentation of Burned-Out Testicular Seminoma. 61
32695250 2020
17
Re: Classic Testicular Seminoma in Men Aged 50 Years or Over: A Case Report and Review of the Literature. 61
32401652 2020
18
Seminoma in an adult striped dolphin Stenella coeruleoalba: tomographic, macroscopical, histological and immunohistochemical study. 61
32701065 2020
19
Unmasked Testicular Seminoma During Use of Hormonal Transgender Woman Therapy: A Hidden hCG-Secreting Tumor. 61
32666014 2020
20
Paraneoplastic tumefactive demyelination in a 47-year-old man with underlying seminoma. 61
32217464 2020
21
Testicular seminoma with large direct iliac nodal metastasis: unusual presentation. 61
32606108 2020
22
Clinical significance of Kelch-like protein 11 antibodies. 61
31953318 2020
23
Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development. 61
32499882 2020
24
Testicular Seminoma Presenting with Bilateral Blindness: Looking Beyond the Eye. 61
32377482 2020
25
Retroperitoneal Lymph Node Dissection as Primary Treatment for Men With Testicular Seminoma: Utilization and Survival Analysis Using the National Cancer Data Base, 2004-2014. 61
31818649 2020
26
Supraclavicular left neck mass: an unusual presentation of metastatic testicular cancer in two older men. 61
32327457 2020
27
Characterization and distribution of sialic acids in human testicular seminoma. 61
32143917 2020
28
Seminoma metastasized to the prostate: A case report and literature review. 61
31890599 2020
29
Widening the spectrum of Lynch syndrome: first report of testicular seminoma attributable to MSH2 loss. 61
31442315 2020
30
[Intimal sarcoma of pulmonary arteries]. 61
32008347 2020
31
Outcomes and Toxicities of Proton and Photon Radiation Therapy for Testicular Seminoma. 61
33274253 2020
32
miR-483-3p, Mediated by KLF9, Functions as Tumor Suppressor in Testicular Seminoma via Targeting MMP9. 61
33659208 2020
33
Clinical stage I synchronous bilateral testicular germ cell tumor with different histopathology: a case report. 61
33680279 2020
34
Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma. 61
32606976 2020
35
Concurrent bilateral testicular tumors with different histopathology: A case report. 61
33680389 2020
36
Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma. 61
32047679 2020
37
Primary tumor size thresholds in stage IA testicular seminoma: Implications for adjuvant therapy after orchiectomy and survival. 61
31704139 2020
38
Contemporary management of early stage testicular seminoma. 61
32055484 2020
39
Re: Adjuvant Carboplatin Therapy in Patients with Clinical Stage 1 Testicular Seminoma: Is Long-Term Morbidity Increased? 61
31518193 2019
40
Pathological risk factors for metastatic disease at presentation in testicular seminomas with focus on the recent pT changes in AJCC TNM eighth edition. 61
31666197 2019
41
Changes in the telocyte/CD34+ stromal cell and α-SMA+ myoid cell networks in human testicular seminoma. 61
31540712 2019
42
Differentiation of testicular seminoma and nonseminomatous germ cell tumor on magnetic resonance imaging. 61
31702681 2019
43
Identification of potential core genes and miRNAs in testicular seminoma via bioinformatics analysis. 61
31545448 2019
44
Wnt suppressor and stem cell regulator TCF7L1 is a sensitive immunohistochemical marker to differentiate testicular seminoma from non-seminomatous germ cell tumor. 61
31381875 2019
45
Adjuvant carboplatin therapy in patients with clinical stage 1 testicular seminoma: is long-term morbidity increased? 61
31286241 2019
46
Cardiac sarcoidosis in a patient with testicular seminoma. 61
31527203 2019
47
Expression of the immune checkpoint receptor TIGIT in seminoma. 61
31423216 2019
48
Contemporary Assessment of Survival Rates in Stage I Testicular Seminoma: A Population-Based Comparison Between Surveillance and Active Treatment After Orchiectomy. 61
31182339 2019
49
Synthesis of a novel platinum(II) complex with 6,7-dichloro-5,8-quinolinedione and the study of its antitumor mechanism in testicular seminoma. 61
31055215 2019
50
[Clinicopathologic features of testicular seminoma with syncytiotrophoblastic cells: Analysis of 3 cases and review of the literature]. 61
32223107 2019

Variations for Testicular Seminoma

Expression for Testicular Seminoma

Search GEO for disease gene expression data for Testicular Seminoma.

Pathways for Testicular Seminoma

GO Terms for Testicular Seminoma

Sources for Testicular Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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