MCID: TST048
MIFTS: 28

Testicular Sex Cord-Stromal Neoplasm

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Sex Cord-Stromal Neoplasm

MalaCards integrated aliases for Testicular Sex Cord-Stromal Neoplasm:

Name: Testicular Sex Cord-Stromal Neoplasm 12 15
Sex Cord-Stromal Tumor of Testis 12 59
Testicular Sex Cord-Stromal Tumor 59

Characteristics:

Orphanet epidemiological data:

59
sex cord-stromal tumor of testis
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe);

Classifications:

Orphanet: 59  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:4757
NCIt 50 C39948
ICD10 via Orphanet 34 C62.1
Orphanet 59 ORPHA363489
UMLS 72 C1515289

Summaries for Testicular Sex Cord-Stromal Neoplasm

Disease Ontology : 12 A sex cord-gonadal stromal tumor that is located in the testis.

MalaCards based summary : Testicular Sex Cord-Stromal Neoplasm, also known as sex cord-stromal tumor of testis, is related to gynandroblastoma and sertoli-leydig cell tumor. An important gene associated with Testicular Sex Cord-Stromal Neoplasm is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Melanocyte Development and Pigmentation and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include testis and testis, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Testicular Sex Cord-Stromal Neoplasm

Diseases in the Testicular Sex Cord-Stromal Neoplasm family:

Testicular Sex Cord-Stromal Benign Neoplasm

Diseases related to Testicular Sex Cord-Stromal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 31.2 FOXL2 DICER1
2 sertoli-leydig cell tumor 31.0 DICER1 AFP
3 testicular granulosa cell tumor 30.7 FOXL2 DICER1 AFP
4 sertoli cell tumor 30.5 SYP PRKAR1A INHA
5 leydig cell tumor 30.5 NR5A1 CYP19A1 AFP
6 precocious puberty 30.0 GNAS CYP19A1
7 gynecomastia 29.4 POMC CYP19A1
8 sex cord-gonadal stromal tumor 29.1 SYP POMC NR5A1 INHA GNAS FOXL2
9 maligant granulosa cell tumor of the ovary 10.6 FOXL2 DICER1
10 corpus luteum cyst 10.6 FOXL2 AFP
11 ovarian cyst 10.5 FOXL2 AFP
12 central nervous system primitive neuroectodermal neoplasm 10.4 SYP DICER1
13 dysgerminoma of ovary 10.4 DICER1 AFP
14 pineal gland cancer 10.4 SYP DICER1
15 malignant sertoli cell tumor 10.4 SYP AFP
16 cloacal exstrophy 10.4 NR5A1 AFP
17 endometrial small cell carcinoma 10.4 SYP AFP
18 malignant teratoma 10.4 SYP AFP
19 pulmonary blastoma 10.3 SYP DICER1
20 juvenile type testicular granulosa cell tumor 10.3 FOXL2 DICER1 AFP
21 mediastinal cancer 10.3 SYP AFP
22 seminal vesicle tumor 10.3 SYP AFP
23 pancreatoblastoma 10.3 SYP AFP
24 mixed germ cell cancer 10.3 TSKS AFP
25 orofaciodigital syndrome viii 10.3 INHA AFP
26 atypical choroid plexus papilloma 10.3 SYP DICER1
27 cystadenofibroma 10.3 INHA AFP
28 rhabdomyosarcoma 10.3
29 spermatocele 10.3 SYP NR5A1
30 tuberculous epididymitis 10.3 POMC AFP
31 central nervous system germ cell tumor 10.3 POMC AFP
32 reproductive organ benign neoplasm 10.3 DICER1 CYP19A1 AFP
33 myxosarcoma 10.2 SYP PRKAR1A
34 testicular disease 10.2 DICER1 AFP
35 mixed cell type cancer 10.2 SYP AFP
36 adrenal cortical hypofunction 10.2 POMC NR5A1
37 tubular adenocarcinoma 10.2 SYP AFP
38 ovarian small cell carcinoma 10.2 SYP INHA
39 ovarian disease 10.2 NR5A1 FOXL2 CYP19A1
40 aromatase excess syndrome 10.2 POMC CYP19A1
41 rh isoimmunization 10.1 POMC AFP
42 ovarian cancer 10.1
43 scott syndrome 10.1
44 gonadoblastoma 10.1
45 alacrima, achalasia, and mental retardation syndrome 10.1
46 brachydactyly 10.1
47 infant gynecomastia 10.1
48 endodermal sinus tumor 10.1
49 sex development disorder 10.1
50 mixed germ cell-sex cord neoplasm 10.1

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Neoplasm:



Diseases related to Testicular Sex Cord-Stromal Neoplasm

Symptoms & Phenotypes for Testicular Sex Cord-Stromal Neoplasm

MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 AFP CYP19A1 DICER1 GNAS NR5A1 POMC
2 endocrine/exocrine gland MP:0005379 10.06 AFP CYP19A1 DICER1 FOXL2 GNAS INHA
3 cardiovascular system MP:0005385 9.98 CYP19A1 DICER1 GNAS INHA NR5A1 POMC
4 growth/size/body region MP:0005378 9.97 CYP19A1 DICER1 FOXL2 GNAS INHA NR5A1
5 homeostasis/metabolism MP:0005376 9.97 AFP CYP19A1 DICER1 FOXL2 GNAS INHA
6 liver/biliary system MP:0005370 9.8 AFP CYP19A1 DICER1 GNAS INHA POMC
7 neoplasm MP:0002006 9.63 AFP DICER1 GNAS INHA POMC PRKAR1A
8 normal MP:0002873 9.56 CYP19A1 DICER1 FOXL2 GNAS INHA NR5A1
9 reproductive system MP:0005389 9.17 AFP CYP19A1 DICER1 FOXL2 INHA NR5A1

Drugs & Therapeutics for Testicular Sex Cord-Stromal Neoplasm

Search Clinical Trials , NIH Clinical Center for Testicular Sex Cord-Stromal Neoplasm

Genetic Tests for Testicular Sex Cord-Stromal Neoplasm

Anatomical Context for Testicular Sex Cord-Stromal Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Testicular Sex Cord-Stromal Neoplasm:

19
Testis

MalaCards organs/tissues related to Testicular Sex Cord-Stromal Neoplasm:

41
Testis

Publications for Testicular Sex Cord-Stromal Neoplasm

Articles related to Testicular Sex Cord-Stromal Neoplasm:

# Title Authors PMID Year
1
Malignant sex cord-stromal tumor of testis. 38
6321807 1984

Variations for Testicular Sex Cord-Stromal Neoplasm

Expression for Testicular Sex Cord-Stromal Neoplasm

Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Neoplasm.

Pathways for Testicular Sex Cord-Stromal Neoplasm

Pathways related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 PRKAR1A POMC
2 10.75 PRKAR1A GNAS
3 10.32 PRKAR1A GNAS
4 10.3 NR5A1 INHA CYP19A1

GO Terms for Testicular Sex Cord-Stromal Neoplasm

Biological processes related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovarian follicle development GO:0001541 9.4 INHA FOXL2
2 renal water homeostasis GO:0003091 9.37 PRKAR1A GNAS
3 cellular response to glucagon stimulus GO:0071377 9.32 PRKAR1A GNAS
4 uterus development GO:0060065 9.26 FOXL2 CYP19A1
5 apoptotic DNA fragmentation GO:0006309 9.16 FOXL2 DICER1
6 positive regulation of follicle-stimulating hormone secretion GO:0046881 8.96 INHA FOXL2
7 female gonad development GO:0008585 8.8 NR5A1 FOXL2 CYP19A1

Sources for Testicular Sex Cord-Stromal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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