MCID: TST048
MIFTS: 33

Testicular Sex Cord-Stromal Neoplasm

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Sex Cord-Stromal Neoplasm

MalaCards integrated aliases for Testicular Sex Cord-Stromal Neoplasm:

Name: Testicular Sex Cord-Stromal Neoplasm 12 15
Sex Cord-Stromal Tumor of Testis 12 60
Testicular Sex Cord-Stromal Tumor 60

Characteristics:

Orphanet epidemiological data:

60
sex cord-stromal tumor of testis
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe);

Classifications:

Orphanet: 60  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:4757
NCIt 51 C39948
ICD10 via Orphanet 35 C62.1
Orphanet 60 ORPHA363489
UMLS 74 C1515289

Summaries for Testicular Sex Cord-Stromal Neoplasm

Disease Ontology : 12 A sex cord-gonadal stromal tumor that is located in the testis.

MalaCards based summary : Testicular Sex Cord-Stromal Neoplasm, also known as sex cord-stromal tumor of testis, is related to sex cord-gonadal stromal tumor and testicular granulosa cell tumor. An important gene associated with Testicular Sex Cord-Stromal Neoplasm is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Neuroscience and Melanocyte Development and Pigmentation. The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include the testis and testis, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Testicular Sex Cord-Stromal Neoplasm

Diseases in the Testicular Sex Cord-Stromal Neoplasm family:

Testicular Sex Cord-Stromal Benign Neoplasm

Diseases related to Testicular Sex Cord-Stromal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 sex cord-gonadal stromal tumor 31.6 AFP CYP19A1 DICER1 INHA NR5A1 POMC
2 testicular granulosa cell tumor 10.4 AFP DICER1
3 juvenile type testicular granulosa cell tumor 10.4 AFP DICER1
4 tuberculous epididymitis 10.4 AFP POMC
5 central nervous system germ cell tumor 10.3 AFP POMC
6 adrenal cortical hypofunction 10.3 NR5A1 POMC
7 orofaciodigital syndrome viii 10.3 AFP INHA
8 mediastinal cancer 10.3 AFP SYP
9 seminal vesicle tumor 10.3 AFP SYP
10 pancreatoblastoma 10.3 AFP SYP
11 pulmonary blastoma 10.3 DICER1 SYP
12 cystadenofibroma 10.3 AFP INHA
13 rh isoimmunization 10.3 AFP POMC
14 gangliocytoma 10.3 POMC SYP
15 cloacal exstrophy 10.3 AFP NR5A1
16 pancreatic endocrine carcinoma 10.3 POMC SYP
17 sella turcica neoplasm 10.3 POMC SYP
18 anorchia 10.3 INSL3 NR5A1
19 tuberculum sellae meningioma 10.3 POMC SYP
20 atypical choroid plexus papilloma 10.2 DICER1 SYP
21 ovarian small cell carcinoma 10.2 INHA SYP
22 spermatocele 10.2 NR5A1 SYP
23 abducens nerve disease 10.2 POMC SYP
24 cystadenoma 10.2 INHA SYP
25 ectopic cushing syndrome 10.2 POMC SYP
26 tubular adenocarcinoma 10.2 AFP SYP
27 aromatase excess syndrome 10.1 CYP19A1 POMC
28 pineoblastoma 10.1 AFP DICER1 SYP
29 2q37 deletion syndrome 10.1
30 myxosarcoma 10.1 PRKAR1A SYP
31 sertoli-leydig cell tumor 10.1 AFP DICER1 INSL3
32 dysgerminoma 10.1 AFP ENO2
33 testicular disease 10.1 AFP DICER1 INSL3
34 melanotic medulloblastoma 10.1 AFP ENO2
35 adrenal cortex disease 10.1 POMC PRKAR1A
36 rete testis adenocarcinoma 10.1 AFP ENO2
37 lymphocytic hypophysitis 10.1 ENO2 POMC
38 adrenal gland disease 10.1 POMC PRKAR1A
39 lung oat cell carcinoma 10.1 ENO2 POMC
40 reproductive organ benign neoplasm 10.1 AFP CYP19A1 DICER1
41 bronchus cancer 10.1 ENO2 POMC
42 acute thyroiditis 10.0 ENO2 POMC
43 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.0 INHA POMC SYP
44 rete testis neoplasm 10.0 AFP ENO2
45 microcystic adenoma 10.0 ENO2 INHA
46 carotid body cancer 10.0 ENO2 SYP
47 urinary bladder small cell neuroendocrine carcinoma 10.0 ENO2 SYP
48 auditory system cancer 10.0 ENO2 SYP
49 sinonasal undifferentiated carcinoma 10.0 ENO2 SYP
50 pancreatic somatostatinoma 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Neoplasm:



Diseases related to Testicular Sex Cord-Stromal Neoplasm

Symptoms & Phenotypes for Testicular Sex Cord-Stromal Neoplasm

MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 AFP CYP19A1 DICER1 ENO2 INSL3 NR5A1
2 endocrine/exocrine gland MP:0005379 9.92 AFP CYP19A1 DICER1 INHA INSL3 NR5A1
3 cellular MP:0005384 9.91 CYP19A1 DICER1 ENO2 INSL3 NR5A1 POMC
4 liver/biliary system MP:0005370 9.73 AFP CYP19A1 DICER1 INHA POMC PRKAR1A
5 neoplasm MP:0002006 9.55 AFP DICER1 INHA POMC PRKAR1A
6 normal MP:0002873 9.43 CYP19A1 DICER1 INHA NR5A1 PRKAR1A SYP
7 reproductive system MP:0005389 9.17 AFP CYP19A1 DICER1 INHA INSL3 NR5A1

Drugs & Therapeutics for Testicular Sex Cord-Stromal Neoplasm

Drugs for Testicular Sex Cord-Stromal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467

Search NIH Clinical Center for Testicular Sex Cord-Stromal Neoplasm

Genetic Tests for Testicular Sex Cord-Stromal Neoplasm

Anatomical Context for Testicular Sex Cord-Stromal Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Testicular Sex Cord-Stromal Neoplasm:

20
The Testis

MalaCards organs/tissues related to Testicular Sex Cord-Stromal Neoplasm:

42
Testis

Publications for Testicular Sex Cord-Stromal Neoplasm

Articles related to Testicular Sex Cord-Stromal Neoplasm:

# Title Authors Year
1
Malignant sex cord-stromal tumor of testis. ( 6321807 )
1984

Variations for Testicular Sex Cord-Stromal Neoplasm

Expression for Testicular Sex Cord-Stromal Neoplasm

Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Neoplasm.

Pathways for Testicular Sex Cord-Stromal Neoplasm

Pathways related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 POMC PRKAR1A SYP
2 10.77 POMC PRKAR1A
3 10.3 CYP19A1 INHA NR5A1

GO Terms for Testicular Sex Cord-Stromal Neoplasm

Cellular components related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.62 ENO2 INHA

Biological processes related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.13 INHA INSL3 POMC
2 female gonad development GO:0008585 8.62 CYP19A1 NR5A1

Molecular functions related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 INHA INSL3 POMC

Sources for Testicular Sex Cord-Stromal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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