MCID: TST048
MIFTS: 32

Testicular Sex Cord-Stromal Neoplasm

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Sex Cord-Stromal Neoplasm

MalaCards integrated aliases for Testicular Sex Cord-Stromal Neoplasm:

Name: Testicular Sex Cord-Stromal Neoplasm 12 15
Sex Cord-Stromal Tumor of Testis 12 58
Testicular Sex Cord-Stromal Tumor 58

Characteristics:

Orphanet epidemiological data:

58
sex cord-stromal tumor of testis
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe);

Classifications:

Orphanet: 58  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:4757
NCIt 49 C39948
ICD10 via Orphanet 33 C62.1
Orphanet 58 ORPHA363489
UMLS 71 C1515289

Summaries for Testicular Sex Cord-Stromal Neoplasm

Disease Ontology : 12 A sex cord-gonadal stromal tumor that is located in the testis.

MalaCards based summary : Testicular Sex Cord-Stromal Neoplasm, also known as sex cord-stromal tumor of testis, is related to mixed germ cell-sex cord neoplasm and gynandroblastoma. An important gene associated with Testicular Sex Cord-Stromal Neoplasm is CALB2 (Calbindin 2), and among its related pathways/superpathways are cAMP signaling pathway and G alpha (s) signalling events. Affiliated tissues include testis, pituitary and ovary, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Testicular Sex Cord-Stromal Neoplasm

Diseases in the Testicular Sex Cord-Stromal Neoplasm family:

Testicular Sex Cord-Stromal Benign Neoplasm

Diseases related to Testicular Sex Cord-Stromal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell-sex cord neoplasm 31.0 FOXL2 CALB2
2 gynandroblastoma 30.9 FOXL2 DICER1 CALB2
3 precocious puberty 30.3 LHCGR GNAS CYP19A1
4 adenoma 30.1 PRKAR1A POMC LHCGR GNAS
5 gonadoblastoma 30.0 WT1 NR5A1 FOXL2 AMH
6 sertoli cell tumor 29.7 WT1 SYP PRKAR1A NR5A1 CYP19A1 CALB2
7 testicular cancer 29.7 STK11 LHCGR INSL3 AFP
8 sertoli-leydig cell tumor 29.5 WT1 SYP MIR302C INSL3 DICER1 CALB2
9 sex cord-gonadal stromal tumor 29.4 WT1 PRKAR1A POMC PDE11A NR5A1 MLANA
10 leydig cell tumor 28.5 SYP NR5A1 LHCGR INSL3 GNAS CYP19A1
11 sex development disorder 27.8 WT1 POMC NR5A1 LHCGR INSL3 CYP19A1
12 testicular granulosa cell tumor 27.4 WT1 MLANA MIR302C GNAS FOXL2 DICER1
13 malignant sertoli cell tumor 10.6 CALB2 AFP
14 maligant granulosa cell tumor of the ovary 10.6 FOXL2 DICER1
15 rete testis neoplasm 10.6 CALB2 AFP
16 rete testis adenocarcinoma 10.6 CALB2 AFP
17 hematocele of tunica vaginalis testis 10.5 CALB2 AFP
18 ovarian melanoma 10.5 MLANA CALB2
19 scrotum neoplasm 10.5 CALB2 AFP
20 fallopian tube carcinosarcoma 10.5 WT1 CALB2
21 infected hydrocele 10.5 CALB2 AFP
22 peritoneal serous adenocarcinoma 10.5 WT1 CALB2
23 malignant epithelial mesothelioma 10.5 WT1 CALB2
24 botryoid rhabdomyosarcoma 10.5 DICER1 AFP
25 diffuse meningeal melanocytosis 10.5 POMC MLANA
26 hepatic angiomyolipoma 10.5 MLANA AFP
27 breast adenoma 10.4 PRKAR1A PDE11A
28 cervical serous adenocarcinoma 10.4 WT1 MLANA
29 malignant biphasic mesothelioma 10.4 WT1 CALB2
30 urachal adenocarcinoma 10.4 GNAS AFP
31 malignant leydig cell tumor 10.4 MLANA CALB2 AFP
32 wolffian duct adenocarcinoma 10.4 WT1 CALB2
33 thymus sarcomatoid carcinoma 10.4 SYP AFP
34 non-gestational choriocarcinoma 10.4 MIR302C AFP
35 pericardium cancer 10.4 WT1 CALB2
36 testicular leydig cell tumor 10.4 PDE11A INSL3
37 tuberculous epididymitis 10.4 POMC CALB2 AFP
38 papillary thymic adenocarcinoma 10.4 SYP CALB2
39 ovarian gonadoblastoma 10.4 WT1 AFP
40 testicular gonadoblastoma 10.4 WT1 AMH
41 epididymal neoplasm 10.4 WT1 CALB2 AFP
42 basophil adenoma 10.4 PRKAR1A POMC PDE11A
43 breast ductal adenoma 10.4 PRKAR1A POMC PDE11A
44 benign mesothelioma 10.4 WT1 CALB2 AFP
45 cystadenofibroma 10.4 WT1 CALB2 AFP
46 retroperitoneal sarcoma 10.4 MLANA CALB2
47 epididymis adenocarcinoma 10.4 WT1 CALB2 AFP
48 epididymis cancer 10.4 WT1 CALB2 AFP
49 diffuse peritoneal leiomyomatosis 10.4 LHCGR CALB2
50 ovarian benign neoplasm 10.4 WT1 CALB2 AFP

Graphical network of the top 20 diseases related to Testicular Sex Cord-Stromal Neoplasm:



Diseases related to Testicular Sex Cord-Stromal Neoplasm

Symptoms & Phenotypes for Testicular Sex Cord-Stromal Neoplasm

MGI Mouse Phenotypes related to Testicular Sex Cord-Stromal Neoplasm:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 AFP CALB2 CYP19A1 DICER1 GNAS INSL3
2 endocrine/exocrine gland MP:0005379 10.3 AFP AMH AMHR2 CYP19A1 DICER1 FOXL2
3 homeostasis/metabolism MP:0005376 10.25 AFP AMH AMHR2 CYP19A1 DICER1 FOXL2
4 cellular MP:0005384 10.22 AMHR2 CYP19A1 DICER1 GNAS INSL3 LHCGR
5 cardiovascular system MP:0005385 10.19 AMHR2 CYP19A1 DICER1 GNAS LHCGR NR5A1
6 liver/biliary system MP:0005370 10.06 AFP CYP19A1 DICER1 GNAS LHCGR POMC
7 neoplasm MP:0002006 10.02 AFP AMH AMHR2 DICER1 GNAS POMC
8 no phenotypic analysis MP:0003012 9.97 AMH AMHR2 DICER1 FOXL2 GNAS MLANA
9 normal MP:0002873 9.96 CALB2 CYP19A1 DICER1 FOXL2 GNAS NR5A1
10 renal/urinary system MP:0005367 9.76 AMHR2 CYP19A1 DICER1 GNAS LHCGR POMC
11 reproductive system MP:0005389 9.73 AFP AMH AMHR2 CYP19A1 DICER1 FOXL2
12 respiratory system MP:0005388 9.17 AMHR2 DICER1 GNAS LHCGR PRKAR1A STK11

Drugs & Therapeutics for Testicular Sex Cord-Stromal Neoplasm

Search Clinical Trials , NIH Clinical Center for Testicular Sex Cord-Stromal Neoplasm

Genetic Tests for Testicular Sex Cord-Stromal Neoplasm

Anatomical Context for Testicular Sex Cord-Stromal Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Testicular Sex Cord-Stromal Neoplasm:

19
Testis

MalaCards organs/tissues related to Testicular Sex Cord-Stromal Neoplasm:

40
Testis, Pituitary, Ovary, Thymus, Breast, Pineal, Cortex

Publications for Testicular Sex Cord-Stromal Neoplasm

Articles related to Testicular Sex Cord-Stromal Neoplasm:

# Title Authors PMID Year
1
Malignant sex cord-stromal tumor of testis. 61
6321807 1984

Variations for Testicular Sex Cord-Stromal Neoplasm

Expression for Testicular Sex Cord-Stromal Neoplasm

Search GEO for disease gene expression data for Testicular Sex Cord-Stromal Neoplasm.

Pathways for Testicular Sex Cord-Stromal Neoplasm

Pathways related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 POMC LHCGR GNAS AMH
2 11.19 POMC PDE11A LHCGR INSL3 GNAS
3 11.02 LHCGR GNAS CYP19A1
4 10.64 NR5A1 LHCGR CYP19A1
5 10.36 AMHR2 AMH

GO Terms for Testicular Sex Cord-Stromal Neoplasm

Biological processes related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic DNA fragmentation GO:0006309 9.46 FOXL2 DICER1
2 male gonad development GO:0008584 9.46 WT1 NR5A1 LHCGR AMHR2
3 gonad development GO:0008406 9.43 WT1 AMH
4 positive regulation of male gonad development GO:2000020 9.4 WT1 NR5A1
5 cellular response to gonadotropin stimulus GO:0071371 9.37 WT1 LHCGR
6 Mullerian duct regression GO:0001880 9.32 AMHR2 AMH
7 negative regulation of female gonad development GO:2000195 9.26 WT1 NR5A1
8 sex determination GO:0007530 9.13 WT1 NR5A1 AMH
9 female gonad development GO:0008585 8.92 NR5A1 FOXL2 CYP19A1 AMHR2

Molecular functions related to Testicular Sex Cord-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 8.8 POMC INSL3 GNAS

Sources for Testicular Sex Cord-Stromal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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