MCID: TST010
MIFTS: 19

Testicular Spermatocytic Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Spermatocytic Seminoma

MalaCards integrated aliases for Testicular Spermatocytic Seminoma:

Name: Testicular Spermatocytic Seminoma 12 15
Spermatocytic Seminoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7891

Summaries for Testicular Spermatocytic Seminoma

MalaCards based summary : Testicular Spermatocytic Seminoma, also known as spermatocytic seminoma, is related to seminoma and spermatocytoma. An important gene associated with Testicular Spermatocytic Seminoma is DNMT3L (DNA Methyltransferase 3 Like), and among its related pathways/superpathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Related phenotype is embryo.

Related Diseases for Testicular Spermatocytic Seminoma

Diseases related to Testicular Spermatocytic Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 seminoma 10.1
2 spermatocytoma 10.1
3 immunodeficiency-centromeric instability-facial anomalies syndrome 8.3 DNMT3A DNMT3B DNMT3L
4 testis seminoma 7.9 DNMT3A DNMT3B DNMT3L H2AFZ

Symptoms & Phenotypes for Testicular Spermatocytic Seminoma

MGI Mouse Phenotypes related to Testicular Spermatocytic Seminoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 DNMT3A DNMT3B DNMT3L H2AFZ

Drugs & Therapeutics for Testicular Spermatocytic Seminoma

Search Clinical Trials , NIH Clinical Center for Testicular Spermatocytic Seminoma

Genetic Tests for Testicular Spermatocytic Seminoma

Anatomical Context for Testicular Spermatocytic Seminoma

Publications for Testicular Spermatocytic Seminoma

Articles related to Testicular Spermatocytic Seminoma:

# Title Authors Year
1
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. ( 22819380 )
2012

Variations for Testicular Spermatocytic Seminoma

Expression for Testicular Spermatocytic Seminoma

Search GEO for disease gene expression data for Testicular Spermatocytic Seminoma.

Pathways for Testicular Spermatocytic Seminoma

Pathways related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 DNMT3A DNMT3B DNMT3L H2AFZ
2
Show member pathways
13.04 DNMT3A DNMT3B DNMT3L H2AFZ
3 11.91 DNMT3A DNMT3B
4 11.54 DNMT3A DNMT3B H2AFZ
5
Show member pathways
11.49 DNMT3A DNMT3B
6
Show member pathways
10.97 DNMT3A DNMT3B
7
Show member pathways
10.95 DNMT3A DNMT3B DNMT3L
8 10.5 DNMT3A DNMT3B

GO Terms for Testicular Spermatocytic Seminoma

Cellular components related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear heterochromatin GO:0005720 8.62 DNMT3A H2AFZ

Biological processes related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.52 DNMT3A DNMT3B
2 methylation GO:0032259 9.51 DNMT3A DNMT3B
3 response to toxic substance GO:0009636 9.49 DNMT3A DNMT3B
4 response to estradiol GO:0032355 9.48 DNMT3A DNMT3B
5 response to ionizing radiation GO:0010212 9.46 DNMT3A DNMT3B
6 negative regulation of gene expression, epigenetic GO:0045814 9.43 DNMT3A DNMT3B
7 response to cocaine GO:0042220 9.4 DNMT3A DNMT3B
8 response to vitamin A GO:0033189 9.37 DNMT3A DNMT3B
9 DNA methylation involved in gamete generation GO:0043046 9.32 DNMT3A DNMT3L
10 regulation of gene expression by genetic imprinting GO:0006349 9.26 DNMT3A DNMT3L
11 C-5 methylation of cytosine GO:0090116 9.16 DNMT3A DNMT3B
12 DNA methylation on cytosine GO:0032776 8.96 DNMT3A DNMT3L
13 DNA methylation GO:0006306 8.8 DNMT3A DNMT3B DNMT3L

Molecular functions related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyltransferase activity GO:0008168 9.16 DNMT3A DNMT3B
2 DNA-methyltransferase activity GO:0009008 8.96 DNMT3A DNMT3B
3 DNA (cytosine-5-)-methyltransferase activity GO:0003886 8.62 DNMT3A DNMT3B

Sources for Testicular Spermatocytic Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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