MCID: TST010
MIFTS: 27

Testicular Spermatocytic Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Spermatocytic Seminoma

MalaCards integrated aliases for Testicular Spermatocytic Seminoma:

Name: Testicular Spermatocytic Seminoma 12 15
Spermatocytic Seminoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7891
UMLS 74 C0334517

Summaries for Testicular Spermatocytic Seminoma

MalaCards based summary : Testicular Spermatocytic Seminoma, also known as spermatocytic seminoma, is related to seminoma and spermatocytoma. An important gene associated with Testicular Spermatocytic Seminoma is DNMT3L (DNA Methyltransferase 3 Like), and among its related pathways/superpathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Affiliated tissues include testis and brain, and related phenotype is embryo.

Related Diseases for Testicular Spermatocytic Seminoma

Diseases related to Testicular Spermatocytic Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 seminoma 10.2
2 spermatocytoma 10.2
3 immunodeficiency-centromeric instability-facial anomalies syndrome 9.1 DNMT3A DNMT3B DNMT3L
4 testis seminoma 9.0 DNMT3A DNMT3B DNMT3L H2AFZ

Symptoms & Phenotypes for Testicular Spermatocytic Seminoma

MGI Mouse Phenotypes related to Testicular Spermatocytic Seminoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 DNMT3A DNMT3B DNMT3L H2AFZ

Drugs & Therapeutics for Testicular Spermatocytic Seminoma

Search Clinical Trials , NIH Clinical Center for Testicular Spermatocytic Seminoma

Genetic Tests for Testicular Spermatocytic Seminoma

Anatomical Context for Testicular Spermatocytic Seminoma

MalaCards organs/tissues related to Testicular Spermatocytic Seminoma:

42
Testis, Brain

Publications for Testicular Spermatocytic Seminoma

Articles related to Testicular Spermatocytic Seminoma:

(show top 50) (show all 87)
# Title Authors Year
1
Erratum: Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. ( 30971586 )
2019
2
Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. ( 30004076 )
2018
3
A case of spermatocytic seminoma in young individual. ( 30093773 )
2018
4
Spermatocytic Seminoma with Brain Metastasis. ( 27815811 )
2017
5
Spermatocytic Seminoma: A Report of 85 Cases Emphasizing its Morphologic Spectrum Including Some Aspects not Widely Known. ( 29280854 )
2017
6
Gigantic spermatocytic seminoma: A rare tumor of germ cell origin. ( 29314802 )
2016
7
Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation. ( 25381827 )
2015
8
Reaction to Yadav S et al: Invalid presentation of bilateral synchronous spermatocytic seminoma. ( 25667696 )
2014
9
The management of retroperitoneal lymphadenopathy in spermatocytic seminoma of the testicle. ( 24361173 )
2014
10
The utility of immunostaining for NUT, GAGE7 and NY-ESO-1 in the diagnosis of spermatocytic seminoma. ( 24393139 )
2014
11
First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: case report and review of the literature. ( 24704931 )
2014
12
Periodic acid Schiff staining-positive spermatocytic seminoma. ( 24750191 )
2014
13
Bilateral spermatocytic seminoma: a case report. ( 25032177 )
2014
14
Therapy-resistant metastasizing anaplastic spermatocytic seminoma: a cytogenetic hybrid: a case report. ( 25141494 )
2014
15
Reaction to Koppad SN et al. Bilateral spermatocytic seminoma: an update on "synchronous" and "sequential" presentation of this rare variant of testicular tumour. ( 25309648 )
2014
16
Bilateral synchronous spermatocytic seminoma: a rare case report. ( 25309674 )
2014
17
A rare case of bilateral sequential spermatocytic seminoma. ( 23915031 )
2013
18
Spermatocytic seminoma: a 21 years' retrospective study in a tertiary care hospital in Pakistan. ( 24228096 )
2013
19
Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease. ( 24363873 )
2013
20
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. ( 22819380 )
2012
21
Bilateral synchronous spermatocytic seminoma: a rare case report from rural India and literature review. ( 23330025 )
2012
22
Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature. ( 23449985 )
2012
23
Spermatocytic seminoma: toward further understanding of pathogenesis. ( 21725972 )
2011
24
Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. ( 21790653 )
2011
25
Spermatocytic seminoma at the national institute of oncology in Morocco. ( 21985228 )
2011
26
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
27
Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma. ( 21086073 )
2011
28
Spermatocytic seminoma: review of the literature and description of a new case of the anaplastic variant. ( 21087978 )
2011
29
Spermatocytic seminoma associated with undifferentiated sarcoma: a rare case report. ( 21393898 )
2011
30
Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. ( 21615421 )
2011
31
OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. ( 21706474 )
2011
32
Spermatocytic seminoma at the National Institute of Oncology in Morocco. ( 21714871 )
2011
33
Spermatocytic seminoma with rhabdomyosarcomatous differentiation: a case report with a review of the literature. ( 19841567 )
2009
34
Spermatocytic seminoma. ( 19961257 )
2009
35
A case of synchronous bilateral spermatocytic seminoma. ( 18312942 )
2008
36
Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis. ( 18425535 )
2008
37
A spermatocytic seminoma with rhabdomyosarcoma transformation and extensive metastases. ( 17762447 )
2007
38
Population based incidence and age distribution of spermatocytic seminoma. ( 17499277 )
2007
39
Classical and spermatocytic seminoma in the dog: histochemical and immunohistochemical findings. ( 17629966 )
2007
40
Anaplastic variant of spermatocytic seminoma. ( 17651911 )
2007
41
Spermatocytic seminoma. ( 17222671 )
2007
42
Metastatic spermatocytic seminoma--an extremely rare disease. ( 16314036 )
2006
43
Metastatic spermatocytic seminoma--an extremely rare disease: Part 2. ( 16541488 )
2006
44
Giant spermatocytic seminoma with massive hemorrhage into accompanying hydrocele: case report. ( 16307336 )
2005
45
Spermatocytic seminoma: a review. ( 15041115 )
2004
46
The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. ( 12605640 )
2003
47
Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. ( 11454979 )
2001
48
Spermatocytic seminoma: a cytology and histology case report with review of the literature. ( 10204108 )
1999
49
Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. ( 10223302 )
1999
50
Anaplastic variant of spermatocytic seminoma. ( 8698307 )
1996

Variations for Testicular Spermatocytic Seminoma

Expression for Testicular Spermatocytic Seminoma

Search GEO for disease gene expression data for Testicular Spermatocytic Seminoma.

Pathways for Testicular Spermatocytic Seminoma

Pathways related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 DNMT3A DNMT3B DNMT3L H2AFZ
2
Show member pathways
13.04 DNMT3A DNMT3B DNMT3L H2AFZ
3 11.91 DNMT3A DNMT3B
4 11.54 DNMT3A DNMT3B H2AFZ
5
Show member pathways
11.5 DNMT3A DNMT3B
6
Show member pathways
10.97 DNMT3A DNMT3B
7
Show member pathways
10.95 DNMT3A DNMT3B DNMT3L
8 10.5 DNMT3A DNMT3B

GO Terms for Testicular Spermatocytic Seminoma

Cellular components related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear heterochromatin GO:0005720 8.62 DNMT3A H2AFZ

Biological processes related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.52 DNMT3A DNMT3B
2 methylation GO:0032259 9.51 DNMT3A DNMT3B
3 response to estradiol GO:0032355 9.49 DNMT3A DNMT3B
4 response to toxic substance GO:0009636 9.48 DNMT3A DNMT3B
5 negative regulation of gene expression, epigenetic GO:0045814 9.46 DNMT3A DNMT3B
6 response to ionizing radiation GO:0010212 9.43 DNMT3A DNMT3B
7 response to cocaine GO:0042220 9.4 DNMT3A DNMT3B
8 DNA methylation involved in gamete generation GO:0043046 9.37 DNMT3A DNMT3L
9 response to vitamin A GO:0033189 9.32 DNMT3A DNMT3B
10 regulation of gene expression by genetic imprinting GO:0006349 9.26 DNMT3A DNMT3L
11 C-5 methylation of cytosine GO:0090116 9.16 DNMT3A DNMT3B
12 DNA methylation on cytosine GO:0032776 8.96 DNMT3A DNMT3L
13 DNA methylation GO:0006306 8.8 DNMT3A DNMT3B DNMT3L

Molecular functions related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.43 DNMT3A DNMT3B DNMT3L
2 methyltransferase activity GO:0008168 9.16 DNMT3A DNMT3B
3 DNA-methyltransferase activity GO:0009008 8.96 DNMT3A DNMT3B
4 DNA (cytosine-5-)-methyltransferase activity GO:0003886 8.62 DNMT3A DNMT3B

Sources for Testicular Spermatocytic Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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