MCID: TST010
MIFTS: 25

Testicular Spermatocytic Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Spermatocytic Seminoma

MalaCards integrated aliases for Testicular Spermatocytic Seminoma:

Name: Testicular Spermatocytic Seminoma 12 15
Spermatocytic Seminoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7891
UMLS 74 C0334517

Summaries for Testicular Spermatocytic Seminoma

MalaCards based summary : Testicular Spermatocytic Seminoma, also known as spermatocytic seminoma, is related to seminoma and spermatocytoma. An important gene associated with Testicular Spermatocytic Seminoma is DNMT3L (DNA Methyltransferase 3 Like), and among its related pathways/superpathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Affiliated tissues include testis, and related phenotype is embryo.

Related Diseases for Testicular Spermatocytic Seminoma

Diseases related to Testicular Spermatocytic Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 seminoma 10.2
2 spermatocytoma 10.2
3 immunodeficiency-centromeric instability-facial anomalies syndrome 9.1 DNMT3A DNMT3B DNMT3L
4 testis seminoma 8.9 DNMT3A DNMT3B DNMT3L H2AFZ

Symptoms & Phenotypes for Testicular Spermatocytic Seminoma

MGI Mouse Phenotypes related to Testicular Spermatocytic Seminoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 DNMT3A DNMT3B DNMT3L H2AFZ

Drugs & Therapeutics for Testicular Spermatocytic Seminoma

Search Clinical Trials , NIH Clinical Center for Testicular Spermatocytic Seminoma

Genetic Tests for Testicular Spermatocytic Seminoma

Anatomical Context for Testicular Spermatocytic Seminoma

MalaCards organs/tissues related to Testicular Spermatocytic Seminoma:

42
Testis

Publications for Testicular Spermatocytic Seminoma

Articles related to Testicular Spermatocytic Seminoma:

(show all 43)
# Title Authors Year
1
Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. ( 30004076 )
2018
2
A case of spermatocytic seminoma in young individual. ( 30093773 )
2018
3
Gigantic spermatocytic seminoma: A rare tumor of germ cell origin. ( 29314802 )
2016
4
First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: case report and review of the literature. ( 24704931 )
2014
5
Periodic acid Schiff staining-positive spermatocytic seminoma. ( 24750191 )
2014
6
Bilateral spermatocytic seminoma: a case report. ( 25032177 )
2014
7
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. ( 22819380 )
2012
8
Giant spermatocytic seminoma with massive hemorrhage into accompanying hydrocele: case report. ( 16307336 )
2005
9
Spermatocytic seminoma: a review. ( 15041115 )
2004
10
Spermatocytic seminoma: a cytology and histology case report with review of the literature. ( 10204108 )
1999
11
Spermatocytic seminoma: sonographic appearance. ( 8839410 )
1996
12
Spermatocytic seminoma: a clinicopathological review of ten patients. ( 8934051 )
1996
13
Polymorphism of spermatocytic seminoma. A morphometric study. ( 7848877 )
1994
14
Spermatocytic seminoma. ( 7927308 )
1994
15
Seminomas of the canine testis. Counterpart of spermatocytic seminoma of men? ( 7967505 )
1994
16
Anaplastic seminoma and spermatocytic seminoma--a retrospective analysis. ( 8122181 )
1993
17
Cytofluorometric analysis of spermatocytic seminoma. ( 8319185 )
1993
18
Cytometric analysis of testicular seminoma and spermatocytic seminoma. ( 8484333 )
1993
19
Spermatocytic seminoma in a maldescended testis. ( 10071558 )
1993
20
Flow cytometry analysis of ploidy and proliferation activity in classical and spermatocytic seminoma. ( 2011207 )
1991
21
Spermatocytic seminoma associated with rhabdomyosarcoma. ( 2252471 )
1990
22
Spermatocytic seminoma--report of 3 cases. ( 2394480 )
1990
23
Fine needle aspiration cytology of spermatocytic seminoma. Report of a case. ( 2675515 )
1989
24
Spermatocytic seminoma with associated sarcoma of the testis. ( 3334976 )
1988
25
Spermatocytic seminoma of testis with sarcomatous transformation. A report of five cases. ( 3341514 )
1988
26
Spermatocytic seminoma of testis with sarcomatous transformation. ( 3421421 )
1988
27
Spermatocytic seminoma: a case report. ( 3324746 )
1987
28
The spermatocytic seminoma: views on pathogenesis. ( 3583416 )
1987
29
Lectin histochemistry of classic and spermatocytic seminoma. ( 3929746 )
1985
30
Spermatocytic seminoma in the rat. ( 4070932 )
1985
31
Spermatocytic seminoma. Ultrastructural and microspectrophotometric observations. ( 6471811 )
1984
32
Spermatocytic seminoma: clinicopathological study of 22 cases. ( 7370958 )
1980
33
Bilateral sequential spermatocytic seminoma. ( 7420608 )
1980
34
Spermatocytic seminoma. ( 936388 )
1976
35
Spermatocytic seminoma. ( 979784 )
1976
36
Spermatocytic seminoma. ( 4843334 )
1974
37
Spermatocytic seminoma of the testis. ( 5058663 )
1972
38
Spermatocytic seminoma. II. Ultrastructural study. ( 5790281 )
1969
39
Spermatocytic seminoma. I. Clinicopathologic study of six cases and review of the literature. ( 5790295 )
1969
40
Spermatocytic seminoma. ( 5696666 )
1968
41
SPERMATOCYTIC SEMINOMA; A VARIANT OF SEMINOMA WITH SPECIFIC MICROSCOPICAL AND CLINICAL CHARACTERISTICS. ( 14297471 )
1965
42
A case report and review of the literature on spermatocytic seminoma of the testis. ( 13969487 )
1963
43
Spermatocytic seminoma of the testis. A report of 3 cases and review of the literature. ( 13749453 )
1961

Variations for Testicular Spermatocytic Seminoma

Expression for Testicular Spermatocytic Seminoma

Search GEO for disease gene expression data for Testicular Spermatocytic Seminoma.

Pathways for Testicular Spermatocytic Seminoma

Pathways related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 DNMT3A DNMT3B DNMT3L H2AFZ
2
Show member pathways
13.04 DNMT3A DNMT3B DNMT3L H2AFZ
3 11.91 DNMT3A DNMT3B
4 11.54 DNMT3A DNMT3B H2AFZ
5
Show member pathways
11.49 DNMT3A DNMT3B
6
Show member pathways
10.97 DNMT3A DNMT3B
7
Show member pathways
10.95 DNMT3A DNMT3B DNMT3L
8 10.5 DNMT3A DNMT3B

GO Terms for Testicular Spermatocytic Seminoma

Cellular components related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear heterochromatin GO:0005720 8.62 DNMT3A H2AFZ

Biological processes related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.52 DNMT3A DNMT3B
2 methylation GO:0032259 9.51 DNMT3A DNMT3B
3 response to estradiol GO:0032355 9.49 DNMT3A DNMT3B
4 response to toxic substance GO:0009636 9.48 DNMT3A DNMT3B
5 negative regulation of gene expression, epigenetic GO:0045814 9.46 DNMT3A DNMT3B
6 response to ionizing radiation GO:0010212 9.43 DNMT3A DNMT3B
7 response to cocaine GO:0042220 9.4 DNMT3A DNMT3B
8 DNA methylation involved in gamete generation GO:0043046 9.37 DNMT3A DNMT3L
9 response to vitamin A GO:0033189 9.32 DNMT3A DNMT3B
10 regulation of gene expression by genetic imprinting GO:0006349 9.26 DNMT3A DNMT3L
11 C-5 methylation of cytosine GO:0090116 9.16 DNMT3A DNMT3B
12 DNA methylation on cytosine GO:0032776 8.96 DNMT3A DNMT3L
13 DNA methylation GO:0006306 8.8 DNMT3A DNMT3B DNMT3L

Molecular functions related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.43 DNMT3A DNMT3B DNMT3L
2 methyltransferase activity GO:0008168 9.16 DNMT3A DNMT3B
3 DNA-methyltransferase activity GO:0009008 8.96 DNMT3A DNMT3B
4 DNA (cytosine-5-)-methyltransferase activity GO:0003886 8.62 DNMT3A DNMT3B

Sources for Testicular Spermatocytic Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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