MCID: TST010
MIFTS: 33

Testicular Spermatocytic Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Spermatocytic Seminoma

MalaCards integrated aliases for Testicular Spermatocytic Seminoma:

Name: Testicular Spermatocytic Seminoma 12 15
Spermatocytic Seminoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7891
UMLS 70 C0334517

Summaries for Testicular Spermatocytic Seminoma

MalaCards based summary : Testicular Spermatocytic Seminoma, also known as spermatocytic seminoma, is related to spermatocytoma and cerebellar ataxia, deafness, and narcolepsy, autosomal dominant. An important gene associated with Testicular Spermatocytic Seminoma is SRA1 (Steroid Receptor RNA Activator 1), and among its related pathways/superpathways are Developmental Biology and Downstream signaling of activated FGFR2. Affiliated tissues include testis, lung and testes, and related phenotypes are growth/size/body region and endocrine/exocrine gland

Related Diseases for Testicular Spermatocytic Seminoma

Diseases related to Testicular Spermatocytic Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 spermatocytoma 30.1 MAGEA4 HRAS FGFR3
2 cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 10.2 DNMT3L DNMT3B
3 seminoma 10.2
4 rare tumor 10.2
5 neuropathy, hereditary sensory, type ie 10.1 DNMT3L DNMT3A
6 sporadic pheochromocytoma/secreting paraganglioma 10.1 RET DNMT3A
7 fgfr craniosynostosis syndromes 10.1 FGFR3 FGFR2
8 hemifacial hyperplasia 10.1 FGFR3 FGFR2
9 renal hypodysplasia/aplasia 3 10.1 RET FGFR3
10 plagiocephaly 10.1 FGFR3 FGFR2
11 sotos syndrome 1 10.1 DNMT3L DNMT3B DNMT3A
12 syndromic craniosynostosis 10.1 FGFR3 FGFR2
13 immunodeficiency-centromeric instability-facial anomalies syndrome 10.1 DNMT3L DNMT3B DNMT3A
14 dacryocystocele 10.0 FGFR3 FGFR2
15 chronic inflammation of lacrimal passage 10.0 FGFR3 FGFR2
16 luteoma 10.0 FGFR3 FGFR2
17 achondroplasia, severe, with developmental delay and acanthosis nigricans 10.0 FGFR3 FGFR2
18 weaver syndrome 10.0 MAGEA4 DNMT3L DNMT3A
19 acanthoma 10.0 FGFR3 FGFR2
20 deafness, autosomal recessive 71 10.0 FGFR3 FGFR2
21 alpha thalassemia-x-linked intellectual disability syndrome 10.0 DNMT3L DNMT3A
22 spitzoid melanoma 10.0 RET HRAS
23 benign struma ovarii 10.0 RET HRAS
24 beare-stevenson cutis gyrata syndrome 10.0 FGFR3 FGFR2
25 lung non-squamous non-small cell carcinoma 10.0 RET HRAS
26 wolffian duct adenocarcinoma 10.0 HRAS FGFR2
27 osteoglophonic dysplasia 9.9 FGFR3 FGFR2
28 cartilage-hair hypoplasia 9.9 H2AZ1 DNMT3L DNMT3B DNMT3A
29 muenke syndrome 9.9 FGFR3 FGFR2
30 giant cell glioblastoma 9.9 HRAS FGFR3 DNMT3A
31 gliosarcoma 9.9 HRAS FGFR3 DNMT3A
32 noonan syndrome-like disorder with loose anagen hair 1 9.9 PTPN11 HRAS
33 noonan syndrome-like disorder with loose anagen hair 9.8 PTPN11 HRAS
34 testicular cancer 9.8 MAGEA4 FGFR3 DNMT3A
35 nevus, epidermal 9.8 HRAS FGFR3 FGFR2
36 pulmonary valve disease 9.8 PTPN11 HRAS
37 legius syndrome 9.7 PTPN11 HRAS
38 cardiofaciocutaneous syndrome 1 9.7 PTPN11 HRAS FGFR3
39 myelodysplastic/myeloproliferative neoplasm 9.7 PTPN11 HRAS DNMT3A
40 thanatophoric dysplasia, type i 9.7 FGFR3 FGFR2
41 hypertelorism, microtia, facial clefting syndrome 9.6 PTPN11 FGFR3 FGFR2
42 primary hyperoxaluria 9.6 RET H2AZ1 DNMT3L DNMT3B DNMT3A
43 squamous cell carcinoma 9.6 MAGEA4 HRAS FGFR3 FGFR2
44 neurofibromatosis-noonan syndrome 9.6 PTPN11 HRAS
45 pilocytic astrocytoma 9.6 RET PTPN11 HRAS
46 neurofibromatosis 9.6 RET PTPN11 HRAS
47 neurofibromatosis, type i 9.6 RET PTPN11 HRAS
48 adenocarcinoma 9.5 RET HRAS FGFR3 FGFR2
49 plasma cell neoplasm 9.5 PTPN11 HRAS FGFR3 DNMT3A
50 myeloproliferative neoplasm 9.5 PTPN11 HRAS FGFR3 DNMT3A

Graphical network of the top 20 diseases related to Testicular Spermatocytic Seminoma:



Diseases related to Testicular Spermatocytic Seminoma

Symptoms & Phenotypes for Testicular Spermatocytic Seminoma

MGI Mouse Phenotypes related to Testicular Spermatocytic Seminoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 DNMT3A DNMT3B FGFR2 FGFR3 H2AZ1 HRAS
2 endocrine/exocrine gland MP:0005379 10.11 DNMT3A DNMT3B DNMT3L FGFR2 H2AZ1 HRAS
3 homeostasis/metabolism MP:0005376 10.1 DNMT3A DNMT3B DNMT3L FGFR2 FGFR3 HRAS
4 digestive/alimentary MP:0005381 10.04 FGFR2 FGFR3 H2AZ1 HRAS NR0B2 PTPN11
5 embryo MP:0005380 10.02 DNMT3A DNMT3B DNMT3L FGFR2 H2AZ1 PTPN11
6 craniofacial MP:0005382 9.99 DNMT3B FGFR2 FGFR3 HRAS PTPN11 SRA1
7 nervous system MP:0003631 9.97 DNMT3A DNMT3B DNMT3L FGFR2 FGFR3 HRAS
8 neoplasm MP:0002006 9.85 DNMT3B FGFR2 FGFR3 HRAS PTPN11 RET
9 no phenotypic analysis MP:0003012 9.73 DNMT3B FGFR2 FGFR3 HRAS PTPN11 RET
10 normal MP:0002873 9.7 DNMT3L FGFR2 FGFR3 HRAS NR0B2 PTPN11
11 reproductive system MP:0005389 9.61 DNMT3A DNMT3B DNMT3L FGFR2 FGFR3 NR0B2
12 skeleton MP:0005390 9.17 DNMT3A DNMT3B FGFR2 FGFR3 HRAS PTPN11

Drugs & Therapeutics for Testicular Spermatocytic Seminoma

Search Clinical Trials , NIH Clinical Center for Testicular Spermatocytic Seminoma

Genetic Tests for Testicular Spermatocytic Seminoma

Anatomical Context for Testicular Spermatocytic Seminoma

MalaCards organs/tissues related to Testicular Spermatocytic Seminoma:

40
Testis, Lung, Testes, Ovary, Bone Marrow, Bone, Prostate

Publications for Testicular Spermatocytic Seminoma

Articles related to Testicular Spermatocytic Seminoma:

(show top 50) (show all 217)
# Title Authors PMID Year
1
Contemporary Trends in Presentation and Management of Spermatocytic Seminoma. 61
33049234 2020
2
Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization. 61
29949388 2019
3
Prognostic and predictive factors in testicular cancer. 61
31115016 2019
4
[Testicular germ cell tumors: Histopathological and molecular features]. 61
30905378 2019
5
Erratum: Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. 61
30971586 2019
6
Adjuvant radiotherapy for Stage I seminoma: A Single-institutional experience. 61
30900627 2019
7
Spermatocytic Seminoma: A Report of 85 Cases Emphasizing Its Morphologic Spectrum Including Some Aspects Not Widely Known. 61
29280854 2019
8
Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. 61
30004076 2018
9
A case of spermatocytic seminoma in young individual. 61
30093773 2018
10
Spermatocytic Tumor With Sarcoma: A Rare Testicular Neoplasm. 61
28440090 2017
11
Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives. 61
28574809 2017
12
[Germ cell and sex cord-stromal tumors of the testis : WHO classification 2016]. 61
28474163 2017
13
The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel. 61
27747907 2017
14
Spermatocytic Seminoma with Brain Metastasis. 61
27815811 2017
15
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. 61
26935559 2016
16
Gigantic spermatocytic seminoma: A rare tumor of germ cell origin. 61
29314802 2016
17
Expression of Transcription Factors and Nuclear Receptors in Mixed Germ Cell-Sex Cord Stromal Tumor and Related Tumors of the Gonads. 61
26107563 2015
18
Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation. 61
25381827 2015
19
Intratubular germ cell neoplasia of the testis: a brief review. 61
25844678 2015
20
Update on the pathology of testicular tumors. 61
26072638 2015
21
Immunohistochemical study of mixed germ cell sex cord stromal tumours in 13 canine testes. 61
25670671 2015
22
Biglycan is a novel binding partner of fibroblast growth factor receptor 3c (FGFR3c) in the human testis. 61
25260943 2015
23
Distribution of testicular tumors in Lebanon: a single institution overview. 61
25921159 2015
24
The utility of immunostaining for NUT, GAGE7 and NY-ESO-1 in the diagnosis of spermatocytic seminoma. 61
24393139 2014
25
Spermatocytic variant of classic seminoma: a report of five cases and a brief review of the literature. 61
25120921 2014
26
Expression of protein gene product 9.5 and Sal-like protein 4 in canine seminomas. 61
24680979 2014
27
Cancer testis antigen expression in testicular germ cell tumorigenesis. 61
24232866 2014
28
Therapy-resistant metastasizing anaplastic spermatocytic seminoma: a cytogenetic hybrid: a case report. 61
25141494 2014
29
[Spermatocytic seminoma. A tumor with many faces]. 61
24682373 2014
30
[Genetics of testicular germ cell tumors]. 61
24819977 2014
31
Cellular evidence for selfish spermatogonial selection in aged human testes. 61
24357637 2014
32
Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors. 61
24577549 2014
33
Histologic variants of seminoma mimicking lymphatic malignancies of the testis: a literature review with a report of case series focusing on problems in differential diagnosis. 61
23958546 2014
34
Periodic acid Schiff staining-positive spermatocytic seminoma. 61
24750191 2014
35
First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: case report and review of the literature. 61
24704931 2014
36
The management of retroperitoneal lymphadenopathy in spermatocytic seminoma of the testicle. 61
24361173 2014
37
Reaction to Koppad SN et al. Bilateral spermatocytic seminoma: an update on "synchronous" and "sequential" presentation of this rare variant of testicular tumour. 61
25309648 2014
38
Bilateral spermatocytic seminoma: a case report. 61
25032177 2014
39
Bilateral synchronous spermatocytic seminoma: a rare case report. 61
25309674 2014
40
Reaction to Yadav S et al: Invalid presentation of bilateral synchronous spermatocytic seminoma. 61
25667696 2014
41
Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease. 61
24363873 2013
42
Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline. 61
24259709 2013
43
Identification and characterization of 2 testicular germ cell markers, Glut3 and CyclinA2. 61
23343953 2013
44
Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age. 61
23623488 2013
45
A rare case of bilateral sequential spermatocytic seminoma. 61
23915031 2013
46
Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases. 61
23165333 2013
47
Testicular and testicular adnexa tumors in the elderly. 61
23059385 2013
48
Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ. 61
23303528 2013
49
Spermatocytic seminoma: a 21 years' retrospective study in a tertiary care hospital in Pakistan. 61
24228096 2013
50
Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas. 61
23885216 2013

Variations for Testicular Spermatocytic Seminoma

Expression for Testicular Spermatocytic Seminoma

Search GEO for disease gene expression data for Testicular Spermatocytic Seminoma.

Pathways for Testicular Spermatocytic Seminoma

Pathways related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 RET PTPN11 HRAS H2AZ1 FGFR3 FGFR2
2
Show member pathways
12.63 PTPN11 HRAS FGFR3 FGFR2
3 12.6 RET HRAS FGFR3 FGFR2
4
Show member pathways
12.56 RET PTPN11 HRAS FGFR2
5
Show member pathways
12.46 PTPN11 HRAS FGFR3 FGFR2
6
Show member pathways
12.4 PTPN11 HRAS FGFR3 FGFR2
7
Show member pathways
12.26 PTPN11 HRAS FGFR3 FGFR2
8 12.2 HRAS FGFR3 DNMT3B DNMT3A
9
Show member pathways
12.03 PTPN11 HRAS FGFR3 FGFR2
10
Show member pathways
11.92 HRAS FGFR3 FGFR2
11 11.88 RET FGFR3 FGFR2
12
Show member pathways
11.85 PTPN11 HRAS FGFR3 FGFR2
13 11.83 HRAS FGFR3 FGFR2
14
Show member pathways
11.81 DNMT3L DNMT3B DNMT3A
15
Show member pathways
11.26 HRAS DNMT3B DNMT3A
16 11.12 PTPN11 HRAS
17
Show member pathways
11.08 PTPN11 HRAS
18 11.03 PTPN11 HRAS
19 10.97 HRAS FGFR3 FGFR2
20 10.9 DNMT3B DNMT3A
21 10.77 RET HRAS FGFR3 FGFR2
22 10.71 RET PTPN11 HRAS

GO Terms for Testicular Spermatocytic Seminoma

Cellular components related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.32 SRA1 PTPN11 NR0B2 HRAS H2AZ1 FGFR3
2 receptor complex GO:0043235 9.13 RET FGFR3 FGFR2

Biological processes related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 RET NR0B2 HRAS DNMT3B
2 MAPK cascade GO:0000165 9.76 RET HRAS FGFR3 FGFR2
3 peptidyl-tyrosine phosphorylation GO:0018108 9.73 RET FGFR3 FGFR2
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.72 RET FGFR3 FGFR2
5 response to ethanol GO:0045471 9.71 NR0B2 FGFR2 DNMT3A
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 PTPN11 HRAS FGFR3 FGFR2
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.61 PTPN11 FGFR3 FGFR2
8 bone morphogenesis GO:0060349 9.59 FGFR3 FGFR2
9 response to vitamin A GO:0033189 9.58 DNMT3B DNMT3A
10 positive regulation of kinase activity GO:0033674 9.58 RET FGFR3 FGFR2
11 DNA methylation involved in gamete generation GO:0043046 9.57 DNMT3L DNMT3A
12 positive regulation of protein kinase B signaling GO:0051897 9.56 RET PTPN11 FGFR3 FGFR2
13 regulation of gene expression by genetic imprinting GO:0006349 9.52 DNMT3L DNMT3A
14 organ growth GO:0035265 9.51 PTPN11 FGFR2
15 positive regulation of phospholipase activity GO:0010518 9.49 FGFR3 FGFR2
16 endochondral bone growth GO:0003416 9.48 FGFR3 FGFR2
17 C-5 methylation of cytosine GO:0090116 9.32 DNMT3B DNMT3A
18 DNA methylation on cytosine GO:0032776 9.16 DNMT3L DNMT3A
19 DNA methylation GO:0006306 9.13 DNMT3L DNMT3B DNMT3A
20 positive regulation of MAPK cascade GO:0043410 8.92 RET HRAS FGFR3 FGFR2

Molecular functions related to Testicular Spermatocytic Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription corepressor activity GO:0003714 9.58 NR0B2 DNMT3B DNMT3A
2 protein tyrosine kinase activity GO:0004713 9.5 RET FGFR3 FGFR2
3 fibroblast growth factor binding GO:0017134 9.37 FGFR3 FGFR2
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 RET FGFR3 FGFR2
5 fibroblast growth factor-activated receptor activity GO:0005007 9.26 FGFR3 FGFR2
6 DNA-methyltransferase activity GO:0009008 8.96 DNMT3B DNMT3A
7 DNA (cytosine-5-)-methyltransferase activity GO:0003886 8.62 DNMT3B DNMT3A

Sources for Testicular Spermatocytic Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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