Testicular Thecoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Testicular Thecoma

MalaCards integrated aliases for Testicular Thecoma:

Name: Testicular Thecoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7676

NCIt ⁴⁹ C39952

UMLS ⁷¹ C1515299

Sources

Summaries for Testicular Thecoma

MalaCards based summary : Testicular Thecoma is related to basal cell nevus syndrome and fibroma. An important gene associated with Testicular Thecoma is PTCH1 (Patched 1). Related phenotypes are cardiovascular system and no phenotypic analysis

Sources

Related Diseases for Testicular Thecoma

Diseases related to Testicular Thecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 22, show less)

#	Related Disease	Score	Top Affiliating Genes
1	basal cell nevus syndrome	10.1
2	fibroma	10.1
3	basal cell carcinoma	10.1
4	ovarian fibrothecoma	10.1
5	46,xy partial gonadal dysgenesis	9.9	ZFPM2 GATA4
6	sinoatrial node disease	9.9	GJD3 GJC3
7	46,xy sex reversal 9	9.9	ZFPM2 GATA4
8	46,xy sex reversal	9.9	ZFPM2 GATA4
9	leukodystrophy, hypomyelinating, 2	9.9	GJD3 GJC3
10	tricuspid atresia	9.9	ZFPM2 GATA4
11	oculodentodigital dysplasia	9.9	GJD3 GJC3
12	diaphragm disease	9.9	ZFPM2 GATA4
13	ebstein anomaly	9.9	ZFPM2 GATA4
14	double outlet right ventricle	9.8	ZFPM2 GATA4
15	heart septal defect	9.8	ZFPM2 GATA4
16	wolff-parkinson-white syndrome	9.8	GJD3 GJC3
17	atrioventricular septal defect	9.8	ZFPM2 GATA4
18	hypoparathyroidism, sensorineural deafness, and renal disease	9.8	ZFPM2 GCM2
19	hypoparathyroidism	9.8	ZFPM2 GCM2
20	hypoplastic left heart syndrome	9.7	ZFPM2 GATA4
21	diaphragmatic hernia, congenital	9.6	ZFPM2 GATA4
22	atrial heart septal defect	9.5	ZFPM2 GATA4

Graphical network of the top 20 diseases related to Testicular Thecoma:

Sources

Symptoms & Phenotypes for Testicular Thecoma

MGI Mouse Phenotypes related to Testicular Thecoma:

⁴⁵ (showing 3, show less)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.55	GATA4 GJC3 GJD3 PTCH1 ZFPM2
2	no phenotypic analysis	MP:0003012	9.35	GATA4 GJD3 PTCH1 UBL4A ZFPM2
3	normal	MP:0002873	9.02	GATA4 GCM2 PTCH1 UBL4A ZFPM2

Sources

Drugs & Therapeutics for Testicular Thecoma

Search Clinical Trials , NIH Clinical Center for Testicular Thecoma

Sources

Genetic Tests for Testicular Thecoma

Sources

Anatomical Context for Testicular Thecoma

Sources

Publications for Testicular Thecoma

Articles related to Testicular Thecoma:

(showing 1, show less)

#	Title	Authors	PMID	Year
1	Testicular thecoma in an 11-year-old boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome). ⁶¹	Ueda M...Ogawa O	20223301	2010

Sources

Genes for Testicular Thecoma

Genes related to Testicular Thecoma (0 elite genes):

(showing 7, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTCH1	Patched 1	Protein Coding	5.9	DISEASES inferred ¹⁵
2	ZFPM2	Zinc Finger Protein, FOG Family Member 2	Protein Coding	5.83	DISEASES inferred ¹⁵
3	GJD3	Gap Junction Protein Delta 3	Protein Coding	5.27	DISEASES inferred ¹⁵
4	GJC3	Gap Junction Protein Gamma 3	Protein Coding	5.12	DISEASES inferred ¹⁵
5	GATA4	GATA Binding Protein 4	Protein Coding	4.82	DISEASES inferred ¹⁵
6	GCM2	Glial Cells Missing Transcription Factor 2	Protein Coding	4.79	DISEASES inferred ¹⁵
7	UBL4A	Ubiquitin Like 4A	Protein Coding	4.77	DISEASES inferred ¹⁵

Sources

Variations for Testicular Thecoma

Sources

Expression for Testicular Thecoma

Search GEO for disease gene expression data for Testicular Thecoma.

Sources

Pathways for Testicular Thecoma

Sources

GO Terms for Testicular Thecoma

Cellular components related to Testicular Thecoma according to GeneCards Suite gene sharing:

(showing 2, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	gap junction	GO:0005921	8.96	GJD3 GJC3
2	connexin complex	GO:0005922	8.62	GJD3 GJC3

Biological processes related to Testicular Thecoma according to GeneCards Suite gene sharing:

(showing 6, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.54	ZFPM2 PTCH1 GATA4
2	response to mechanical stimulus	GO:0009612	9.32	PTCH1 GATA4
3	cell communication	GO:0007154	9.26	GJD3 GJC3
4	embryonic organ development	GO:0048568	9.16	ZFPM2 PTCH1
5	cell-cell signaling	GO:0007267	9.13	GJD3 GJC3 GATA4
6	cardiac muscle tissue development	GO:0048738	8.62	ZFPM2 GATA4

Molecular functions related to Testicular Thecoma according to GeneCards Suite gene sharing:

(showing 2, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II transcription factor binding	GO:0001085	8.96	ZFPM2 GATA4
2	gap junction channel activity	GO:0005243	8.62	GJD3 GJC3

Sources

Sources for Testicular Thecoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia