MCID: TST044
MIFTS: 50

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 58 12
Spermatic Cord Torsion 12 45 15 74
Torsion of Testicular Cord 58
Torsion of Testicle 12
Torsion of Testis 12

Characteristics:

OMIM:

58
Inheritance:
male-limited autosomal dominant vs. y-linked


HPO:

33
testicular torsion:
Inheritance autosomal dominant inheritance y-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11996
OMIM 58 187400
ICD9CM 36 608.2 608.20
MeSH 45 D013086
NCIt 51 C26885
SNOMED-CT 69 49198006 81996005
MedGen 43 C0037856
SNOMED-CT via HPO 70 263681008 287085006 42030000
UMLS 74 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to ischemia and teratoma. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Apoptosis Pathway and EGF/EGFR Signaling Pathway. The drugs Androgens and Hormones, Hormone Substitutes, and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and spinal cord, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 77 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

Description from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.6 ACE BCL2 NOS3
2 teratoma 11.3
3 cryptorchidism, unilateral or bilateral 10.4
4 anterolateral myocardial infarction 10.3 ACE CHKB
5 hypersensitivity vasculitis 10.3 ACE CD79A
6 purpura 10.3
7 henoch-schoenlein purpura 10.2
8 orchitis 10.2
9 marek disease 10.2 ACE TP53
10 renal artery disease 10.2 ACE NOS3
11 lymphosarcoma 10.2 CD79A GSR
12 vasculogenic impotence 10.2 ACE NOS3
13 aortic coarctation 10.2 ACE NOS3
14 ischemic heart disease 10.2 ACE NOS3
15 diastolic heart failure 10.2 ACE NOS3
16 hydrocele 10.2
17 optic nerve neoplasm 10.2 ACE TP53
18 sexual disorder 10.2 ACE NOS3
19 ulcerative stomatitis 10.2 CD79A TP53
20 arteritic anterior ischemic optic neuropathy 10.1 ACE NOS3
21 ischemic optic neuropathy 10.1 ACE NOS3
22 mature teratoma 10.1 PCNA TP53
23 oral leukoplakia 10.1 PCNA TP53
24 renovascular hypertension 10.1 ACE NOS3
25 fibrillary astrocytoma 10.1 PCNA TP53
26 thrombosis 10.1
27 seminoma 10.1
28 infertility 10.1
29 appendicitis 10.1
30 vasculitis 10.1
31 epididymo-orchitis 10.1
32 angina pectoris 10.1 ACE NOS3
33 penile disease 10.1 NOS3 TP53
34 acute mountain sickness 10.1 ACE NOS3
35 hypoxia 10.1
36 malignant teratoma 10.0 BCL2 TP53
37 cervical carcinosarcoma 10.0 BCL2 TP53
38 syphilis 10.0 BCL2 CD79A
39 left bundle branch hemiblock 10.0 ACE TWIST1
40 epidermoid cysts 10.0
41 cerebral palsy 10.0
42 inguinal hernia 10.0
43 compartment syndrome 10.0
44 soft tissue sarcoma 10.0 BCL2 TP53
45 inverted papilloma 10.0 PCNA TP53
46 peripheral artery disease 10.0 ACE NOS3
47 mature b-cell neoplasm 10.0 CD79A TP53
48 focal cortical dysplasia, type ii 10.0 BCL2 TP53
49 hidradenocarcinoma 10.0 BCL2 TP53
50 marginal zone b-cell lymphoma 10.0 BCL2 CD79A

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Human phenotypes related to Testicular Torsion:

33
# Description HPO Frequency HPO Source Accession
1 testicular torsion 33 HP:0100813
2 abnormality of the genitourinary system 33 HP:0000119

Symptoms via clinical synopsis from OMIM:

58
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM:

187400

MGI Mouse Phenotypes related to Testicular Torsion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 ACE BCL2 CHKB INSL3 NOS3 TP53
2 adipose tissue MP:0005375 9.77 ACE BCL2 NOS3 PCNA TP53
3 endocrine/exocrine gland MP:0005379 9.73 ACE BCL2 INSL3 NOS3 PCNA TP53
4 muscle MP:0005369 9.55 BCL2 CHKB NOS3 TP53 TWIST1
5 renal/urinary system MP:0005367 9.35 ACE BCL2 CD79A NOS3 TP53
6 reproductive system MP:0005389 9.1 ACE BCL2 INSL3 NOS3 PCNA TP53

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Androgens
2 Hormones, Hormone Substitutes, and Hormone Antagonists
3 Hormones
4 Estrogens
5 Hormone Antagonists
6 Follicle Stimulating Hormone

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
2 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109 Not Applicable
4 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

42
Testis, Testes, Spinal Cord, Ovary, B Cells, Neutrophil, Appendix

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 931)
# Title Authors Year
1
Pediatric testicular torsion: does patient transfer affect time to intervention or surgical outcomes at a rural tertiary care center? ( 31101044 )
2019
2
The Impact of Testicular Torsion on Testicular Function. ( 31081295 )
2019
3
Identifying systems delays in assessment, diagnosis, and operative management for testicular torsion in a single-payer health-care system. ( 31005635 )
2019
4
Whole-Exome Sequencing Identifies Novel Heterozygous Mutation in RAF1 in Family With Neonatal Testicular Torsion. ( 30904638 )
2019
5
The role of ultrasound imaging in adult patients with testicular torsion: a systematic review and meta-analysis. ( 30847624 )
2019
6
Parents' awareness and knowledge of testicular torsion: A cross-sectional study. ( 30787572 )
2019
7
Testicular torsion in a newborn: a case report. ( 30771800 )
2019
8
Testicular torsion and reperfusion: Germ cell DNA damage and development. ( 30746737 )
2019
9
Testicular granulomatous vasculitis mimicking testicular torsion in an anti-neutrophil cytoplasmic antibody-associated vasculitis patient. ( 30719308 )
2019
10
Testicular Torsion Postorchiopexy: A Case of Twisted Hammock. ( 30611657 )
2019
11
Neutrophil-Lymphocyte Ratio Predicts Organ Salvage in Testicular Torsion with Marginal Diagnostic Delay. ( 30584993 )
2019
12
Remote ischemic conditioning in a rat model of testicular torsion: does it offer testicular protection? ( 30502312 )
2019
13
Predictive value of hematological parameters in testicular torsion: retrospective investigation of data from a high-volume tertiary care center. ( 30453814 )
2019
14
Children with Cryptorchidism Complicated by Testicular Torsion: A Case Series. ( 30368501 )
2019
15
Controversies in the management of neonatal testicular torsion: A meta-analysis. ( 30098810 )
2019
16
Mean Platelet Volume and Testicular Torsion: New Findings. ( 30091128 )
2019
17
Testicular cavernous hemangioma associated with testicular torsion - case report and review of literature. ( 30055478 )
2018
18
Testicular torsion in a patient with Ehlers-Danlos syndrome. ( 29572364 )
2018
19
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats. ( 29902763 )
2018
20
Direction of Rotation in Testicular Torsion and Identification of Predictors of Testicular Salvage. ( 29203186 )
2018
21
Testicular torsion and reperfusion: evidences for biochemical and molecular alterations. ( 29086205 )
2018
22
Case of an Airsoft pellet induced epididymal laceration and secondary testicular torsion with the loss of affected testis. ( 29034179 )
2018
23
Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats. ( 28730645 )
2018
24
Incidence of Low-Grade Testicular Injury in Orchidectomy Specimens Post-testicular Torsion. ( 28505690 )
2018
25
Can haematologic parameters be used for differential diagnosis of testicular torsion and epididymitis? ( 28497463 )
2018
26
Do repeat ultrasounds affect orchiectomy rate in patients with testicular torsion treated at a pediatric institution? ( 30704855 )
2018
27
Suspected testicular torsion in children: diagnostic dilemma and recommendation for a lower threshold for initiation of surgical exploration. ( 30584529 )
2018
28
Bilateral Neonatal Testicular Torsion; Hidden Surgical Nightmare. ( 30525011 )
2018
29
Surgical practice among pediatric surgeons and pediatric urologists in the Kingdom of Saudi Arabia for the management of suspected testicular torsion. ( 30520506 )
2018
30
A Pair of Testicular Torsion Medicolegal Cases with Caveats: The Ball's in Your Court. ( 30443606 )
2018
31
A case of bilateral perinatal testicular torsion that presented with unilateral torsion; necessity of contralateral testis exploration. ( 30395797 )
2018
32
Testicular Torsion. ( 30288149 )
2018
33
Voiceless disability: A worth case of bilateral infrainguinal testicular torsion in a patient with cerebropalsy. ( 30167304 )
2018
34
Testicular torsion in older men: It must always be considered. ( 30116718 )
2018
35
BET 2: Twist score in cases of suspected paediatric testicular torsion. ( 30115779 )
2018
36
Frontiers in pediatric testicular torsion: An integrated review of prevailing trends and management outcomes. ( 30087037 )
2018
37
Blocking natural killer cells in testicular torsion may prevent autoimmunity against low expressing major histocompatibility complex class I germ cells. ( 29806600 )
2018
38
Genetic analysis of the human insulin-like 3 gene in pediatric patients with testicular torsion. ( 29785651 )
2018
39
Microcirculatory effects of sildenafil in experimental testicular torsion in rats. ( 29785490 )
2018
40
Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats. ( 29773452 )
2018
41
A 26-Year-Old Male with a 14-Year History of Left Intermittent Testicular Torsion Treated with Self-Manual Reduction. ( 29692698 )
2018
42
Relationship of Low Temperature with Testicular Torsion. ( 29690968 )
2018
43
Re: State Appellant Cases for Testicular Torsion: Case Review from 1985 to 2015. ( 29642340 )
2018
44
Re: Standardized Process to Improve Patient Flow from the Emergency Room to the Operating Room for Pediatric Patients with Testicular Torsion. ( 29642339 )
2018
45
Parental awareness of testicular torsion amongst Irish parents. ( 29594530 )
2018
46
Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism. ( 29573663 )
2018
47
Oxytocin for preventing injury due to testicular torsion/detorsion in rats. ( 29569694 )
2018
48
Management of Paediatric Testicular Torsion - Are we adhering to Royal College of Surgeons (RCS) recommendations. ( 29543045 )
2018
49
Testicular torsion with preserved flow: key sonographic features and value-added approach to diagnosis. ( 29468365 )
2018
50
Tunica vaginalis flap for salvaging testicular torsion: A matched cohort analysis. ( 29454628 )
2018

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to glucose starvation GO:0042149 9.51 BCL2 TP53
2 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.49 BCL2 TP53
3 B cell proliferation GO:0042100 9.48 BCL2 CD79A
4 blood vessel remodeling GO:0001974 9.46 ACE NOS3
5 homeostasis of number of cells within a tissue GO:0048873 9.43 BCL2 NOS3
6 response to gamma radiation GO:0010332 9.4 BCL2 TP53
7 cell aging GO:0007569 9.37 BCL2 TP53
8 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 BCL2 TP53
9 aortic valve morphogenesis GO:0003180 9.26 NOS3 TWIST1
10 endocardial cushion morphogenesis GO:0003203 9.16 NOS3 TWIST1
11 cellular response to hypoxia GO:0071456 9.13 BCL2 TP53 TWIST1
12 regulation of mitochondrial membrane permeability GO:0046902 8.62 BCL2 TP53

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.26 GSR NOS3
2 histone acetyltransferase binding GO:0035035 9.16 PCNA TP53
3 protein phosphatase 2A binding GO:0051721 8.96 BCL2 TP53
4 protease binding GO:0002020 8.8 BCL2 INSL3 TP53

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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