MCID: TST044
MIFTS: 51

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 58 12
Spermatic Cord Torsion 12 45 15 74
Torsion of Testicular Cord 58
Torsion of Testicle 12
Torsion of Testis 12

Characteristics:

OMIM:

58
Inheritance:
male-limited autosomal dominant vs. y-linked


Classifications:



External Ids:

Disease Ontology 12 DOID:11996
OMIM 58 187400
ICD9CM 36 608.2 608.20
MeSH 45 D013086
NCIt 51 C26885
SNOMED-CT 69 49198006 81996005
MedGen 43 C0037856
SNOMED-CT via HPO 70 287085006 42030000
UMLS 74 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to ischemia and teratoma. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Apoptosis Pathway and EGF/EGFR Signaling Pathway. The drugs Androgens and Hormones have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and ovary, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 77 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

Description from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.7 ACE BCL2 NOS3
2 teratoma 11.3
3 cryptorchidism, unilateral or bilateral 10.4
4 mature teratoma 10.3 PCNA TP53
5 oral leukoplakia 10.3 PCNA TP53
6 ulcerative stomatitis 10.3 CD79A TP53
7 fibrillary astrocytoma 10.3 PCNA TP53
8 purpura 10.2
9 marek disease 10.2 ACE TP53
10 hypersensitivity vasculitis 10.2 ACE CD79A
11 malignant teratoma 10.2 BCL2 TP53
12 henoch-schoenlein purpura 10.2
13 orchitis 10.2
14 cervical carcinosarcoma 10.2 BCL2 TP53
15 optic nerve neoplasm 10.2 ACE TP53
16 soft tissue sarcoma 10.2 BCL2 TP53
17 focal cortical dysplasia, type ii 10.2 BCL2 TP53
18 hidradenocarcinoma 10.2 BCL2 TP53
19 hydrocele 10.2
20 renal artery disease 10.2 ACE NOS3
21 penile disease 10.2 NOS3 TP53
22 inverted papilloma 10.1 PCNA TP53
23 vasculogenic impotence 10.1 ACE NOS3
24 syphilis 10.1 BCL2 CD79A
25 aortic coarctation 10.1 ACE NOS3
26 keratocystic odontogenic tumor 10.1 BCL2 TP53
27 lymphosarcoma 10.1 CD79A GSR
28 ischemic heart disease 10.1 ACE NOS3
29 diastolic heart failure 10.1 ACE NOS3
30 retinal ischemia 10.1 BCL2 PCNA
31 mature b-cell neoplasm 10.1 CD79A TP53
32 sexual disorder 10.1 ACE NOS3
33 thrombosis 10.1
34 seminoma 10.1
35 infertility 10.1
36 appendicitis 10.1
37 vasculitis 10.1
38 epididymo-orchitis 10.1
39 anterolateral myocardial infarction 10.1 ACE CHKB
40 arteritic anterior ischemic optic neuropathy 10.1 ACE NOS3
41 marginal zone b-cell lymphoma 10.1 BCL2 CD79A
42 ischemic optic neuropathy 10.1 ACE NOS3
43 renovascular hypertension 10.1 ACE NOS3
44 angina pectoris 10.0 ACE NOS3
45 hypoxia 10.0
46 actinic keratosis 10.0 PCNA TP53
47 suppressor of tumorigenicity 3 10.0 BCL2 PCNA TP53
48 gastric lymphoma 10.0 BCL2 PCNA TP53
49 acute mountain sickness 10.0 ACE NOS3
50 epidermoid cysts 10.0

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Human phenotypes related to Testicular Torsion:

33
# Description HPO Frequency HPO Source Accession
1 testicular torsion 33 HP:0100813
2 abnormality of the genitourinary system 33 HP:0000119

Symptoms via clinical synopsis from OMIM:

58
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM:

187400

MGI Mouse Phenotypes related to Testicular Torsion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 ACE BCL2 CHKB INSL3 NOS3 TP53
2 adipose tissue MP:0005375 9.77 ACE BCL2 NOS3 PCNA TP53
3 endocrine/exocrine gland MP:0005379 9.73 ACE BCL2 INSL3 NOS3 PCNA TP53
4 muscle MP:0005369 9.55 BCL2 CHKB NOS3 TP53 TWIST1
5 renal/urinary system MP:0005367 9.35 ACE BCL2 CD79A NOS3 TP53
6 reproductive system MP:0005389 9.1 ACE BCL2 INSL3 NOS3 PCNA TP53

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Androgens
2 Hormones
3 Hormone Antagonists
4 Estrogens
5 Hormones, Hormone Substitutes, and Hormone Antagonists
6 Follicle Stimulating Hormone

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
2 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109 Not Applicable
4 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

42
Testis, Testes, Ovary, Neutrophil, Appendix, Spinal Cord, Spleen

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 928)
# Title Authors Year
1
Neutrophil-Lymphocyte Ratio Predicts Organ Salvage in Testicular Torsion with Marginal Diagnostic Delay. ( 30584993 )
2019
2
Testicular Torsion Postorchiopexy: A Case of Twisted Hammock. ( 30611657 )
2019
3
Testicular granulomatous vasculitis mimicking testicular torsion in an anti-neutrophil cytoplasmic antibody-associated vasculitis patient. ( 30719308 )
2019
4
Testicular torsion and reperfusion: Germ cell DNA damage and development. ( 30746737 )
2019
5
Testicular torsion in a newborn: a case report. ( 30771800 )
2019
6
Parents' awareness and knowledge of testicular torsion: A cross-sectional study. ( 30787572 )
2019
7
The role of ultrasound imaging in adult patients with testicular torsion: a systematic review and meta-analysis. ( 30847624 )
2019
8
Whole-Exome Sequencing Identifies Novel Heterozygous Mutation in RAF1 in Family with Neonatal Testicular Torsion. ( 30904638 )
2019
9
FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion. ( 29411905 )
2018
10
Testicular torsion with preserved flow: key sonographic features and value-added approach to diagnosis. ( 29468365 )
2018
11
Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats. ( 29773452 )
2018
12
Case of an Airsoft pellet induced epididymal laceration and secondary testicular torsion with the loss of affected testis. ( 29034179 )
2018
13
Microcirculatory effects of sildenafil in experimental testicular torsion in rats. ( 29785490 )
2018
14
Re: State Appellant Cases for Testicular Torsion: Case Review from 1985 to 2015. ( 29642340 )
2018
15
Genetic analysis of the human insulin-like 3 gene in pediatric patients with testicular torsion. ( 29785651 )
2018
16
Re: Standardized Process to Improve Patient Flow from the Emergency Room to the Operating Room for Pediatric Patients with Testicular Torsion. ( 29642339 )
2018
17
Testicular torsion in a patient with Ehlers-Danlos syndrome. ( 29572364 )
2018
18
Parental awareness of testicular torsion amongst Irish parents. ( 29594530 )
2018
19
Tunica vaginalis flap for salvaging testicular torsion: A matched cohort analysis. ( 29454628 )
2018
20
The Effect of Tunica Albuginea Incision on Testicular Tissue After Detorsion in the Experimental Model of Testicular Torsion. ( 29250764 )
2018
21
The ultrasonographic "whirlpool sign" in testicular torsion: valuable tool or waste of valuable time? A systematic review and meta-analysis. ( 29335899 )
2018
22
Oxytocin for preventing injury due to testicular torsion/detorsion in rats. ( 29569694 )
2018
23
Bilateral testicular torsion in a 36-week neonate. ( 29437711 )
2018
24
A 26-Year-Old Male with a 14-Year History of Left Intermittent Testicular Torsion Treated with Self-Manual Reduction. ( 29692698 )
2018
25
Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism. ( 29573663 )
2018
26
Relationship of Low Temperature with Testicular Torsion. ( 29690968 )
2018
27
Direction of Rotation in Testicular Torsion and Identification of Predictors of Testicular Salvage. ( 29203186 )
2018
28
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats. ( 29902763 )
2018
29
Can haematologic parameters be used for differential diagnosis of testicular torsion and epididymitis? ( 28497463 )
2018
30
Management of Paediatric Testicular Torsion - Are we adhering to Royal College of Surgeons (RCS) recommendations. ( 29543045 )
2018
31
Straight to the Operating Room: An Emergent Surgery Track for Acute Testicular Torsion Transfers. ( 29246339 )
2018
32
Testicular Torsion in an Infant with Undescended Testis. ( 29429568 )
2018
33
Blocking natural killer cells in testicular torsion may prevent autoimmunity against low expressing major histocompatibility complex class I germ cells. ( 29806600 )
2018
34
The ameliorative effects of Ginkgo biloba on apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion. ( 29411888 )
2018
35
Testicular cavernous hemangioma associated with testicular torsion - case report and review of literature. ( 30055478 )
2018
36
Acquired undescended testis and possibly associated testicular torsion in children with cerebral palsy or neuromuscular disease. ( 30219308 )
2018
37
Concurrent testicular torsion and acute incarcerated inguinal hernia in an adolescent boy. ( 30368478 )
2018
38
Protective effects of Tadalafil and darbepoetin against ischemia - reperfusion injury in a rat testicular torsion model. ( 30130015 )
2018
39
Incidence of Low-Grade Testicular Injury in Orchidectomy Specimens Post-testicular Torsion. ( 28505690 )
2018
40
Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats. ( 28730645 )
2018
41
Frontiers in pediatric testicular torsion: An integrated review of prevailing trends and management outcomes. ( 30087037 )
2018
42
Mean Platelet Volume and Testicular Torsion: New Findings. ( 30091128 )
2018
43
Controversies in the management of neonatal testicular torsion: A meta-analysis. ( 30098810 )
2018
44
BET 2: Twist score in cases of suspected paediatric testicular torsion. ( 30115779 )
2018
45
Testicular torsion in older men: It must always be considered. ( 30116718 )
2018
46
Voiceless disability: A worth case of bilateral infrainguinal testicular torsion in a patient with cerebropalsy. ( 30167304 )
2018
47
Testicular Torsion. ( 30288149 )
2018
48
Children with Cryptorchidism Complicated by Testicular Torsion: A Case Series. ( 30368501 )
2018
49
A case of bilateral perinatal testicular torsion that presented with unilateral torsion; necessity of contralateral testis exploration. ( 30395797 )
2018
50
A Pair of Testicular Torsion Medicolegal Cases with Caveats: The Ball's in Your Court. ( 30443606 )
2018

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to glucose starvation GO:0042149 9.51 BCL2 TP53
2 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.49 BCL2 TP53
3 B cell proliferation GO:0042100 9.48 BCL2 CD79A
4 blood vessel remodeling GO:0001974 9.46 ACE NOS3
5 homeostasis of number of cells within a tissue GO:0048873 9.43 BCL2 NOS3
6 response to gamma radiation GO:0010332 9.4 BCL2 TP53
7 cell aging GO:0007569 9.37 BCL2 TP53
8 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 BCL2 TP53
9 aortic valve morphogenesis GO:0003180 9.26 NOS3 TWIST1
10 endocardial cushion morphogenesis GO:0003203 9.16 NOS3 TWIST1
11 cellular response to hypoxia GO:0071456 9.13 BCL2 TP53 TWIST1
12 regulation of mitochondrial membrane permeability GO:0046902 8.62 BCL2 TP53

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.26 GSR NOS3
2 histone acetyltransferase binding GO:0035035 9.16 PCNA TP53
3 protein phosphatase 2A binding GO:0051721 8.96 BCL2 TP53
4 protease binding GO:0002020 8.8 BCL2 INSL3 TP53

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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