MCID: TST044
MIFTS: 47

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 57 11 75 33
Spermatic Cord Torsion 11 43 14 71
Torsion of Testis 11 31 33
Torsion of Spermatic Cord Nos 33
Torsion of Testicular Cord 57
Torsion of Spermatic Cord 33
Torsion of Testicle 11

Characteristics:


Inheritance:

Male-limited autosomal dominant vs Y-linked 57

Classifications:



External Ids:

Disease Ontology 11 DOID:11996
OMIM® 57 187400
ICD9CM 34 608.2
MeSH 43 D013086
NCIt 49 C26885
SNOMED-CT 68 198046000
ICD10 31 N44
MedGen 40 C0037856
ICD11 33 2141360941
UMLS 71 C0037856

Summaries for Testicular Torsion

MalaCards based summary: Testicular Torsion, also known as spermatic cord torsion, is related to orchitis and epididymo-orchitis. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and NF-kappaB Pathway. The drugs Follicle Stimulating Hormone and Androgens have been mentioned in the context of this disorder. Affiliated tissues include testis, appendix and testes, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia: 75 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

More information from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 509)
# Related Disease Score Top Affiliating Genes
1 orchitis 31.2 TNF IL1B EPPIN CRP
2 epididymo-orchitis 31.0 CST9L CRP AFP
3 testicular infarct 31.0 CRP AFP
4 purpura 30.9 TNF IL1B CRP
5 ischemia 30.8 TNF NOS3 MPO CASP3
6 inguinal hernia 30.7 RXFP2 INSL3 CRP AMH AFP
7 henoch-schoenlein purpura 30.6 TNF MPO CRP
8 common cold 30.6 TNF IL1B CRP
9 urinary tract infection 30.5 TNF IL1B CRP
10 appendicitis 30.4 TNF MPO IL1B CRP
11 vasculitis 30.4 TNF MPO IL1B CRP
12 periodic fever, familial, autosomal dominant 30.4 TNF IL1B CRP
13 hematocele of tunica vaginalis testis 30.2 CRP AFP
14 infected hydrocele 30.2 CRP AFP
15 urethritis 30.2 TNF IL1B CRP
16 pyelonephritis 30.1 TNF IL1B CRP
17 spermatogenic failure, x-linked, 1 30.1 EPPIN DDX4 AMH
18 pneumonia 30.1 TNF MPO IL1B CRP
19 male infertility 30.0 SHBG RXFP2 INSL3 EPPIN DDX4
20 covid-19 30.0 TNF NOS3 IL1B CRP
21 exanthem 29.9 TNF MPO IL1B CRP
22 gastroenteritis 29.9 TNF IL1B CRP
23 testicular cancer 29.8 SHBG RXFP2 INSL3 EPPIN BCL2 AMH
24 cerebral palsy 29.8 TNF NOS3 MPO IL1B CRP
25 polyarteritis nodosa 29.8 TNF MPO CRP
26 brucellosis 29.8 TNF MPO CRP
27 migraine with or without aura 1 29.8 TNF NOS3 IL1B CRP
28 cryptorchidism, unilateral or bilateral 29.8 SHBG RXFP2 INSL3 EPPIN DDX4 CATSPER1
29 complete androgen insensitivity syndrome 29.8 SHBG INSL3 AMH
30 central nervous system vasculitis 29.7 TNF MPO IL1B CRP
31 acute pancreatitis 29.7 TNF MPO IL1B CRP
32 ovarian cyst 29.5 SHBG CRP AMH AFP
33 varicocele 29.5 TNF SHBG NOS3 CASP3 BCL2 AMH
34 androgen insensitivity syndrome 29.5 SHBG RXFP2 INSL3 EPPIN AMH
35 infertility 29.5 SHBG RXFP2 INSL3 EPPIN DDX4 CATSPER1
36 testicular disease 29.3 TNF SHBG RXFP2 INSL3 EPPIN CASP3
37 disorder of sexual development 29.3 SHBG RXFP2 INSL3 EPPIN AMH AFP
38 peripheral nervous system disease 29.3 TNF MPO IL1B CRP CASP3 BCL2
39 spermatogenic failure 28.9 SHBG RXFP2 PGK2 INSL3 EPPIN DDX4
40 atrophy of testis 10.7
41 hydrocele 10.6
42 frontotemporal dementia 10.5
43 anorchia 10.4
44 testicular gonadoblastoma 10.3 AMH AFP
45 physiological polycythemia 10.3 TNF IL1B
46 subserous uterine fibroid 10.3 AMH AFP
47 anterior scleritis 10.3 TNF CRP
48 leydig cell hypoplasia 10.3 INSL3 EPPIN AMH
49 palladium allergic contact dermatitis 10.3 TNF IL1B
50 persistent mullerian duct syndrome 10.3 RXFP2 INSL3 AMH

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Human phenotypes related to Testicular Torsion:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 testicular torsion 30 HP:0100813
2 abnormality of the genitourinary system 30 HP:0000119
3 torsion of appendix of testis 30 HP:0033180

Symptoms via clinical synopsis from OMIM®:

57 (Updated 24-Oct-2022)
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM®:

187400 (Updated 24-Oct-2022)

GenomeRNAi Phenotypes related to Testicular Torsion according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 AFP AMH BCL2 C20orf173 C9orf131 CASP3
2 no effect GR00402-S-2 10.18 AMH BCL2 C20orf173 C9orf131 CASP3 CATSPER1

MGI Mouse Phenotypes related to Testicular Torsion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 AFP AMH BCL2 CASP3 DDX4 EPPIN
2 reproductive system MP:0005389 9.47 AFP AMH BCL2 CASP3 CATSPER1 CST9L

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Follicle Stimulating Hormone
2 Androgens
3 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
2 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109
4 Is There a Toll-like 4 Receptor Relationship in Patients With Testicular Torsion? Completed NCT05558072
5 Prospective Observational Study on SEBBIN Silicone Gel-filled Testicular Implants Recruiting NCT05097820
6 Testicular Function After Testicular Torsion Not yet recruiting NCT04137965

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

Organs/tissues related to Testicular Torsion:

MalaCards : Testis, Appendix, Testes, Ovary, Bone Marrow, Neutrophil, Endothelial

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 2524)
# Title Authors PMID Year
1
Familial torsion of the spermatic cord. 62 57
2908936 1989
2
Neonatal testicular torsion in two brothers. 62 57
1121017 1975
3
Familial occurrence of testicular torsion. 62 57
13718864 1960
4
Familial torsion of the testicle. 57
3986454 1985
5
Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion. 62
35593125 2022
6
Intraoperative evaluation of testicular vascularization and perfusion in rat testicles with indocyanine green (ICG)/near-infrared (NIR) fluorescent imaging after torsion-detorsion and reperfusion. 62
36087144 2022
7
Torsed spermatocele, a rare cause of acute scrotum: Report of a case and review of literature. 62
35959225 2022
8
Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. 62
35748405 2022
9
Effect of sunitinib on testicular oxidative and proinflammatory damage induced by ischemia-reperfusion in rats. 62
34172383 2022
10
Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation. 62
35914339 2022
11
Testicular torsion in Ireland: a 10-year analysis of incidence and risk of orchidectomy. 62
34671927 2022
12
Perinatal Testicular Torsion in Northern Ireland: A Nationwide 10-Year Review. 62
36270310 2022
13
Ultrasonographical features of perinatal testicular torsion: an assessment of interobserver variability among radiologists and pediatric urologists. 62
36261731 2022
14
Testicular salvage: using machine learning algorithm to develop a predictive model in testicular torsion. 62
35915183 2022
15
Clinical Safety Recommendations for Testicular Torsion: Analysis of 101 Claims Settled with Compensation in Spain and France. 62
36195061 2022
16
Unexpected twist: a case report of asymptomatic synchronous contralateral testicular torsion identified during scrotal exploration. 62
36210610 2022
17
Azoospermia and sperm retrieval in post-pubertal testicular torsion; benefits and limitations. 62
36241065 2022
18
Perinatal testicular torsion: The clear cut, the controversial, and the "quiet" scenarios. 62
34753560 2022
19
Testicular torsion disparities in the pediatric population. 62
36229235 2022
20
Where are the paediatric patients with testicular torsion during the COVID-19 pandemic? 62
34664222 2022
21
Effect of tunica albuginea incision on testicular tissue in testicular torsion. 62
36169476 2022
22
The role of neutrophil-to-lymphocyte ratio as a predictor of testicular torsion in children. 62
36175289 2022
23
[Testicular torsion - etiology, diagnostic pathway and treatment]. 62
36064921 2022
24
Reassessment of a Decade of Experience on Testicular Torsion: Are We Making a Mistake? 62
36063809 2022
25
Recurrent testicular torsion post orchidopexy - an occult emergency: a systematic review. 62
35257473 2022
26
Mean platelet volume is the most valuable hematologic parameter in differentiating testicular torsion from epididymitis within the golden time. 62
36217394 2022
27
Real-world management of testicular torsion: Level of adherence to the EAU Pediatric Urology guidelines. 62
36266168 2022
28
Delayed diagnosis of serious paediatric conditions in 13 regional emergency departments. 62
36180208 2022
29
The evaluation of citral effects on experimental unilateral testicular ischemia/reperfusion injury. 62
36163582 2022
30
Increasing utilization of the TWIST score in workup of patients with acute scrotal pain: Role in diagnosis and risk stratification. 62
36244901 2022
31
Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study. 62
35932053 2022
32
Successful salvage of torsion testis by means of intraoperative indocyanine green fluorescence imaging. 62
35951275 2022
33
Current risk landscape of point-of-care ultrasound in pediatric emergency medicine in medical malpractice litigation. 62
35623178 2022
34
Validation of testicular workup for ischemia and suspected torsion score in patients with acute scrotum. 62
35970737 2022
35
Scrotal Masses. 62
35977130 2022
36
Effect of ferulic acid on testicular damage caused by torsion-detorsion in rats. 62
35996879 2022
37
Real-time Ultrasound-Guided Manual Testicular Detorsion: A Case Report. 62
36049193 2022
38
Presentations of the Acute Scrotum During the COVID-19 Pandemic: Experiences of a Non-urological Centre. 62
36127974 2022
39
Surge in testicular torsion in pediatric patients during the COVID-19 pandemic. 62
34392971 2022
40
Salvage Surgery Rates for Pediatric Testicular Torsion: Comparison of the Pre- and Post-Quality Metric Eras. 62
35343239 2022
41
A meta-analysis of testicular torsion and orchiectomy in pediatric patients during the COVID-19 pandemic. 62
35216796 2022
42
Shear wave elastography for the evaluation of testicular salvage after testicular torsion. 62
35973680 2022
43
A simplified ultrasound approach to diagnose testicular torsion and predict unsalvageable testis. 62
35437523 2022
44
Differences in Clinical Characteristics Between Prepubescent and Postpubescent Males With Testicular Torsion. 62
35982605 2022
45
Testicular torsion; clinical diagnosis or imaging diagnosis? 62
35663801 2022
46
Protective effect of Smilax excelsa L. pretreatment via antioxidant, anti-inflammatory effects, and activation of Nrf-2/HO-1 pathway in testicular torsion model. 62
35347733 2022
47
Diagnosing with a TWIST: Systematic Review and Meta-Analysis of a Testicular Torsion Risk Score. 62
35238603 2022
48
Protective effect of remote ischemic postconditioning in rat testes after testicular torsion/detorsion. 62
35398995 2022
49
Pediatric Non-Testicular Torsion Acute Scrotum-Is the Use of Prophylactic Antibiotics in Patients With Normal Urine Analysis Justified? 62
35878814 2022
50
LOCAL-IGF-1 and GH application IMPROVES germ cell histology, spermatogenesis and fertility after experimental testicular torsion and detorsion. 62
35933306 2022

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

Pathways related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 TNF NOS3 MPO IL1B BCL2
2
Show member pathways
12.19 NOS3 IL1B CASP3 BCL2
3 11.65 TNF IL1B CASP3
4 11.63 NOS3 CASP3 BCL2
5 11.21 TNF CASP3 BCL2
6 11.13 TNF IL1B CASP3 BCL2
7 11.1 TNF CASP3 BCL2
8 11 TNF CASP3 BCL2
9 10.76 TNF CASP3 BCL2
10 10.61 TNF CRP BCL2
11 10.36 RXFP2 INSL3
12 10 TNF MPO IL1B

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide-mediated signaling pathway GO:0031663 9.91 TNF NOS3 IL1B
2 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.88 TNF IL1B BCL2
3 positive regulation of fever generation GO:0031622 9.76 TNF IL1B
4 sequestering of triglyceride GO:0030730 9.67 TNF IL1B
5 response to organic cyclic compound GO:0014070 9.65 TNF CASP3 BCL2 AMH
6 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
7 cellular response to organic substance GO:0071310 9.55 IL1B CASP3 BCL2
8 response to lipopolysaccharide GO:0032496 9.28 TNF NOS3 MPO IL1B CASP3
9 response to gold nanoparticle GO:1990268 9.26 TNF MPO

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.23 TNF INSL3 CASP3 BCL2

Sources for Testicular Torsion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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