MCID: TST044
MIFTS: 48

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 57 12
Spermatic Cord Torsion 12 44 15 73
Torsion of Testicular Cord 57
Torsion of Testicle 12
Torsion of Testis 12

Characteristics:

OMIM:

57
Inheritance:
male-limited autosomal dominant vs. y-linked


Classifications:



External Ids:

OMIM 57 187400
Disease Ontology 12 DOID:11996
ICD9CM 35 608.2 608.20
MeSH 44 D013086
NCIt 50 C26885
SNOMED-CT 68 49198006 81996005
MedGen 42 C0037856
SNOMED-CT via HPO 69 287085006 42030000
UMLS 73 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to teratoma and ischemia. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and 13 signaling. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and appendix, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 76 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

Description from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 teratoma 11.3
2 ischemia 10.6
3 cryptorchidism, unilateral or bilateral 10.4
4 epididymitis 10.4
5 purpura 10.2
6 orchitis 10.2
7 mature teratoma 10.2 TP53 PCNA
8 oral leukoplakia 10.2 TP53 PCNA
9 fibrillary astrocytoma 10.2 TP53 PCNA
10 hydrocele 10.2
11 malignant teratoma 10.2 TP53 BCL2
12 cervical carcinosarcoma 10.1 TP53 BCL2
13 ulcerative stomatitis 10.1 TP53 CD79A
14 marek disease 10.1 TP53 ACE
15 soft tissue sarcoma 10.1 TP53 BCL2
16 hidradenocarcinoma 10.1 TP53 BCL2
17 focal cortical dysplasia, type ii 10.1 TP53 BCL2
18 optic nerve neoplasm 10.1 TP53 ACE
19 keratocystic odontogenic tumor 10.1 TP53 BCL2
20 inverted papilloma 10.1 TP53 PCNA
21 hypersensitivity vasculitis 10.1 CD79A ACE
22 thrombosis 10.1
23 seminoma 10.1
24 infertility 10.1
25 appendicitis 10.1
26 epididymo-orchitis 10.1
27 mature b-cell neoplasm 10.1 TP53 CD79A
28 syphilis 10.1 CD79A BCL2
29 anterolateral myocardial infarction 10.1 CHKB ACE
30 hypoxia 10.0
31 suppressor of tumorigenicity 3 10.0 TP53 PCNA BCL2
32 gastric lymphoma 10.0 TP53 PCNA BCL2
33 actinic keratosis 10.0 TP53 PCNA
34 epidermoid cysts 10.0
35 cerebral palsy 10.0
36 inguinal hernia 10.0
37 compartment syndrome 10.0
38 vasculitis 10.0
39 marginal zone b-cell lymphoma 10.0 CD79A BCL2
40 lymphosarcoma 10.0 GSR CD79A
41 meningoencephalitis 10.0 CHKB CD79A
42 lymphoma, non-hodgkin, familial 10.0 TP53 CD79A BCL2
43 left bundle branch hemiblock 9.9 TWIST1 ACE
44 cohen syndrome 9.9
45 pulmonary alveolar microlithiasis 9.9
46 spastic paraplegia 17, autosomal dominant 9.9
47 testicular regression syndrome 9.9
48 androgen insensitivity syndrome 9.9
49 fragile x syndrome 9.9
50 polyarteritis nodosa, childhood-onset 9.9

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Symptoms via clinical synopsis from OMIM:

57
G U:
testicular torsion
hypermobility of testicle


Clinical features from OMIM:

187400

Human phenotypes related to Testicular Torsion:

32
# Description HPO Frequency HPO Source Accession
1 testicular torsion 32 HP:0100813
2 abnormality of the genitourinary system 32 HP:0000119

MGI Mouse Phenotypes related to Testicular Torsion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.1 ACE BCL2 CATSPER1 INSL3 PCNA TP53

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Estrogens
4 Androgens
5 Hormones, Hormone Substitutes, and Hormone Antagonists
6 Follicle Stimulating Hormone

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
2 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109 Not Applicable
4 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

41
Testis, Testes, Appendix, Kidney, Spinal Cord, Spleen, B Cells

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 918)
# Title Authors Year
1
FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion. ( 29411905 )
2018
2
Testicular torsion with preserved flow: key sonographic features and value-added approach to diagnosis. ( 29468365 )
2018
3
Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats. ( 29773452 )
2018
4
Case of an Airsoft pellet induced epididymal laceration and secondary testicular torsion with the loss of affected testis. ( 29034179 )
2018
5
Microcirculatory effects of sildenafil in experimental testicular torsion in rats. ( 29785490 )
2018
6
Re: State Appellant Cases for Testicular Torsion: Case Review from 1985 to 2015. ( 29642340 )
2018
7
Genetic analysis of the human insulin-like 3 gene in pediatric patients with testicular torsion. ( 29785651 )
2018
8
Re: Standardized Process to Improve Patient Flow from the Emergency Room to the Operating Room for Pediatric Patients with Testicular Torsion. ( 29642339 )
2018
9
Testicular torsion in a patient with Ehlers-Danlos syndrome. ( 29572364 )
2018
10
Parental awareness of testicular torsion amongst Irish parents. ( 29594530 )
2018
11
Tunica vaginalis flap for salvaging testicular torsion: A matched cohort analysis. ( 29454628 )
2018
12
The Effect of Tunica Albuginea Incision on Testicular Tissue After Detorsion in the Experimental Model of Testicular Torsion. ( 29250764 )
2018
13
The ultrasonographic "whirlpool sign" in testicular torsion: valuable tool or waste of valuable time? A systematic review and meta-analysis. ( 29335899 )
2018
14
Oxytocin for preventing injury due to testicular torsion/detorsion in rats. ( 29569694 )
2018
15
Bilateral testicular torsion in a 36-week neonate. ( 29437711 )
2018
16
A 26-Year-Old Male with a 14-Year History of Left Intermittent Testicular Torsion Treated with Self-Manual Reduction. ( 29692698 )
2018
17
Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism. ( 29573663 )
2018
18
Relationship of Low Temperature with Testicular Torsion. ( 29690968 )
2018
19
Direction of Rotation in Testicular Torsion and Identification of Predictors of Testicular Salvage. ( 29203186 )
2018
20
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats. ( 29902763 )
2018
21
Can haematologic parameters be used for differential diagnosis of testicular torsion and epididymitis? ( 28497463 )
2018
22
Management of Paediatric Testicular Torsion - Are we adhering to Royal College of Surgeons (RCS) recommendations. ( 29543045 )
2018
23
Straight to the Operating Room: An Emergent Surgery Track for Acute Testicular Torsion Transfers. ( 29246339 )
2018
24
Testicular Torsion in an Infant with Undescended Testis. ( 29429568 )
2018
25
Blocking natural killer cells in testicular torsion may prevent autoimmunity against low expressing major histocompatibility complex class I germ cells. ( 29806600 )
2018
26
Testicular cavernous hemangioma associated with testicular torsion - case report and review of literature. ( 30055478 )
2018
27
Acquired undescended testis and possibly associated testicular torsion in children with cerebral palsy or neuromuscular disease. ( 30219308 )
2018
28
Concurrent testicular torsion and acute incarcerated inguinal hernia in an adolescent boy. ( 30368478 )
2018
29
Protective effects of Tadalafil and darbepoetin against ischemia - reperfusion injury in a rat testicular torsion model. ( 30130015 )
2018
30
Incidence of Low-Grade Testicular Injury in Orchidectomy Specimens Post-testicular Torsion. ( 28505690 )
2018
31
Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats. ( 28730645 )
2018
32
The ameliorative effects of Ginkgo biloba on apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion. ( 29411888 )
2018
33
Frontiers in pediatric testicular torsion: An integrated review of prevailing trends and management outcomes. ( 30087037 )
2018
34
Mean Platelet Volume and Testicular Torsion: New Findings. ( 30091128 )
2018
35
Controversies in the management of neonatal testicular torsion: A meta-analysis. ( 30098810 )
2018
36
BET 2: Twist score in cases of suspected paediatric testicular torsion. ( 30115779 )
2018
37
Testicular torsion in older men: It must always be considered. ( 30116718 )
2018
38
Voiceless disability: A worth case of bilateral infrainguinal testicular torsion in a patient with cerebropalsy. ( 30167304 )
2018
39
Testicular Torsion. ( 30288149 )
2018
40
Children with Cryptorchidism Complicated by Testicular Torsion: A Case Series. ( 30368501 )
2018
41
A case of bilateral perinatal testicular torsion that presented with unilateral torsion; necessity of contralateral testis exploration. ( 30395797 )
2018
42
A Pair of Testicular Torsion Medicolegal Cases with Caveats: The Ball's in Your Court. ( 30443606 )
2018
43
Predictive value of hematological parameters in testicular torsion: retrospective investigation of data from a high-volume tertiary care center. ( 30453814 )
2018
44
Remote ischemic conditioning in a rat model of testicular torsion: does it offer testicular protection? ( 30502312 )
2018
45
Surgical practice among pediatric surgeons and pediatric urologists in the Kingdom of Saudi Arabia for the management of suspected testicular torsion. ( 30520506 )
2018
46
Bilateral Neonatal Testicular Torsion; Hidden Surgical Nightmare. ( 30525011 )
2018
47
Testicular torsion and reperfusion: evidences for biochemical and molecular alterations. ( 29086205 )
2017
48
Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Model. ( 29094225 )
2017
49
Immediate and delayed effects of atmospheric temperature in the incidence of testicular torsion. ( 29295782 )
2017
50
How do they get here: Does the method of transportation impact salvage for patients with testicular torsion? ( 28291658 )
2017

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.63 BCL2 TP53 TWIST1
2 cellular response to UV GO:0034644 9.48 PCNA TP53
3 cellular response to glucose starvation GO:0042149 9.43 BCL2 TP53
4 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.4 BCL2 TP53
5 B cell proliferation GO:0042100 9.37 BCL2 CD79A
6 response to gamma radiation GO:0010332 9.32 BCL2 TP53
7 cell aging GO:0007569 9.26 BCL2 TP53
8 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.16 BCL2 TP53
9 cellular response to hypoxia GO:0071456 9.13 BCL2 TP53 TWIST1
10 regulation of mitochondrial membrane permeability GO:0046902 8.62 BCL2 TP53

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase binding GO:0035035 9.16 PCNA TP53
2 protein phosphatase 2A binding GO:0051721 8.96 BCL2 TP53
3 protease binding GO:0002020 8.8 BCL2 INSL3 TP53

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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