MCID: TST044
MIFTS: 45

Testicular Torsion

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 57 12
Spermatic Cord Torsion 12 44 15 73
Torsion of Testicular Cord 57
Torsion of Testicle 12
Torsion of Testis 12

Characteristics:

OMIM:

57
Inheritance:
male-limited autosomal dominant vs. y-linked


Classifications:



External Ids:

OMIM 57 187400
Disease Ontology 12 DOID:11996
ICD9CM 35 608.2 608.20
MeSH 44 D013086
NCIt 50 C26885
MedGen 42 C0037856
SNOMED-CT via HPO 69 287085006 42030000
UMLS 73 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to testicular disease and teratoma. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and 13 signaling. The drugs Androgens and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and ovary, and related phenotypes are abnormality of the genitourinary system and testicular torsion

Wikipedia : 76 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

Description from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 testicular disease 28.8 CATSPER1 INSL3 TWIST1
2 teratoma 11.1
3 cervical carcinosarcoma 10.4 BCL2 TP53
4 soft tissue sarcoma 10.4 BCL2 TP53
5 mature teratoma 10.4 PCNA TP53
6 oral leukoplakia 10.4 PCNA TP53
7 fibrillary astrocytoma 10.4 PCNA TP53
8 inverted papilloma 10.3 PCNA TP53
9 hidradenocarcinoma 10.3 BCL2 TP53
10 focal cortical dysplasia, type ii 10.3 BCL2 TP53
11 syphilis 10.3 BCL2 CD79A
12 ulcerative stomatitis 10.3 CD79A TP53
13 epididymitis 10.3
14 orthostatic proteinuria 10.3 ACE CD79A
15 chronic salpingitis 10.3 CD79A TP53
16 marek disease 10.2 ACE TP53
17 keratocystic odontogenic tumor 10.2 BCL2 TP53
18 lichen disease 10.2 CD79A TP53
19 meningoencephalitis 10.2 CD79A CHKB
20 optic nerve neoplasm 10.1 ACE TP53
21 ischemia 10.1
22 orchitis 10.1
23 granulomatous hepatitis 10.0 ACE CD79A
24 hydrocele 10.0
25 suppressor of tumorigenicity 3 10.0 BCL2 PCNA TP53
26 gastric lymphoma 10.0 BCL2 PCNA TP53
27 adenoid cystic carcinoma 10.0 BCL2 PCNA TP53
28 seminoma 10.0
29 epididymo-orchitis 10.0
30 hypersensitivity reaction type iv disease 10.0 ACE CD79A
31 multiple cranial nerve palsy 10.0 ACE TP53
32 mature b-cell neoplasm 9.9 CD79A TP53
33 cryptorchidism, unilateral or bilateral 9.9
34 lymphoma, non-hodgkin, familial 9.9 BCL2 CD79A TP53
35 pharynx cancer 9.8 CD79A TP53
36 norwegian scabies 9.8 CD79A TWIST1
37 cohen syndrome 9.7
38 spastic paraplegia 17, autosomal dominant 9.7
39 testicular regression syndrome 9.7
40 androgen insensitivity syndrome 9.7
41 cardiac tamponade 9.7
42 ehlers-danlos syndrome 9.7
43 urethritis 9.7
44 acute pancreatitis 9.7
45 antiphospholipid syndrome 9.7
46 purpura 9.7
47 sertoli cell tumor 9.7
48 pancreatitis 9.7
49 infertility 9.7
50 cocaine abuse 9.7

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Symptoms via clinical synopsis from OMIM:

57
GU:
testicular torsion
hypermobility of testicle


Clinical features from OMIM:

187400

Human phenotypes related to Testicular Torsion:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the genitourinary system 32 HP:0000119
2 testicular torsion 32 HP:0100813

MGI Mouse Phenotypes related to Testicular Torsion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.1 BCL2 CATSPER1 INSL3 PCNA TP53 ACE

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Androgens
2 Hormone Antagonists
3 Hormones
4 Hormones, Hormone Substitutes, and Hormone Antagonists
5 Estrogens
6 Follicle Stimulating Hormone

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Unknown status NCT01812109 Not Applicable
2 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
3 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
4 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

41
Testis, Testes, Ovary

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 200)
# Title Authors Year
1
FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion. ( 29411905 )
2018
2
Testicular torsion with preserved flow: key sonographic features and value-added approach to diagnosis. ( 29468365 )
2018
3
Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats. ( 29773452 )
2018
4
Case of an Airsoft pellet induced epididymal laceration and secondary testicular torsion with the loss of affected testis. ( 29034179 )
2018
5
Microcirculatory effects of sildenafil in experimental testicular torsion in rats. ( 29785490 )
2018
6
Re: State Appellant Cases for Testicular Torsion: Case Review from 1985 to 2015. ( 29642340 )
2018
7
Genetic analysis of the human insulin-like 3 gene in pediatric patients with testicular torsion. ( 29785651 )
2018
8
Re: Standardized Process to Improve Patient Flow from the Emergency Room to the Operating Room for Pediatric Patients with Testicular Torsion. ( 29642339 )
2018
9
Testicular torsion in a patient with Ehlers-Danlos syndrome. ( 29572364 )
2018
10
Parental awareness of testicular torsion amongst Irish parents. ( 29594530 )
2018
11
Tunica vaginalis flap for salvaging testicular torsion: A matched cohort analysis. ( 29454628 )
2018
12
The Effect of Tunica Albuginea Incision on Testicular Tissue After Detorsion in the Experimental Model of Testicular Torsion. ( 29250764 )
2018
13
The ultrasonographic "whirlpool sign" in testicular torsion: valuable tool or waste of valuable time? A systematic review and meta-analysis. ( 29335899 )
2018
14
Oxytocin for preventing injury due to testicular torsion/detorsion in rats. ( 29569694 )
2018
15
Bilateral testicular torsion in a 36-week neonate. ( 29437711 )
2018
16
A 26-Year-Old Male with a 14-Year History of Left Intermittent Testicular Torsion Treated with Self-Manual Reduction. ( 29692698 )
2018
17
Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism. ( 29573663 )
2018
18
Relationship of Low Temperature with Testicular Torsion. ( 29690968 )
2018
19
Direction of Rotation in Testicular Torsion and Identification of Predictors of Testicular Salvage. ( 29203186 )
2018
20
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats. ( 29902763 )
2018
21
Can haematologic parameters be used for differential diagnosis of testicular torsion and epididymitis? ( 28497463 )
2018
22
Management of Paediatric Testicular Torsion - Are we adhering to Royal College of Surgeons (RCS) recommendations. ( 29543045 )
2018
23
Straight to the Operating Room: An Emergent Surgery Track for Acute Testicular Torsion Transfers. ( 29246339 )
2018
24
Testicular Torsion in an Infant with Undescended Testis. ( 29429568 )
2018
25
Blocking natural killer cells in testicular torsion may prevent autoimmunity against low expressing major histocompatibility complex class I germ cells. ( 29806600 )
2018
26
The ameliorative effects of Ginkgo biloba on apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion. ( 29411888 )
2018
27
Testicular torsion and reperfusion: evidences for biochemical and molecular alterations. ( 29086205 )
2017
28
Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Model. ( 29094225 )
2017
29
Immediate and delayed effects of atmospheric temperature in the incidence of testicular torsion. ( 29295782 )
2017
30
How do they get here: Does the method of transportation impact salvage for patients with testicular torsion? ( 28291658 )
2017
31
Probucol Reduces Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats. ( 29081888 )
2017
32
Diffusion-Weighted Imaging and Color Doppler Ultrasound in Evaluation of Partial Testicular Torsion in Rat Model. ( 29657618 )
2017
33
Testicular torsion in undescended testis: A persistent challenge. ( 29264215 )
2017
34
Factors Associated with Delayed Presentation and Misdiagnosis of Testicular Torsion: A Case-Control Study. ( 28427778 )
2017
35
Intra-scrotal testicular torsion of a classical seminoma in an elderly patient: a case report and literature review. ( 28775840 )
2017
36
Bilateral Simultaneous Testicular Torsion in a Newborn: Report of a Case. ( 29439758 )
2017
37
Testicular Torsion: Current Evaluation and Management. ( 29240370 )
2017
38
A case of seminoma presented with clinical manifestations of testicular torsion. ( 28969409 )
2017
39
Degree of twisting and duration of symptoms are prognostic factors of testis salvage during episodes of testicular torsion. ( 29354505 )
2017
40
Intermittent testicular torsion. ( 29192631 )
2017
41
Bilateral testicular torsion in an adolescent: a case with challenging diagnosis. ( 29219274 )
2017
42
Improving Organ Salvage in Testicular Torsion: Comparative Study of Patients Undergoing vs Not Undergoing Preoperative Manual Detorsion. ( 27697579 )
2017
43
Transient testicular torsion: from early diagnosis to appropriate therapeutic intervention (a prospective clinical study). ( 29121037 )
2017
44
Protective effects of polydatin on experimental testicular torsion and detorsion injury in rats. ( 28442025 )
2017
45
Patient with antiphospholipid syndrome presenting with testicular torsion-like symptoms. ( 28932692 )
2017
46
Selective Nuclear Factor Kappa b (NFkB) Inhibitor, Pyrrolidium Dithiocarbamate Prevents, Long-Term Histologic Damage in Ischemia-Reperfusion Injuries after Delayed Testicular Torsion. ( 27351326 )
2016
47
Treatment patterns, testicular loss and disparities in inpatient surgical management of testicular torsion in boys: a population-based study 1998-2010. ( 27322784 )
2016
48
Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion-induced ischaemia/reperfusion injury in rats. ( 26589469 )
2016
49
Ultrasound assessment of perinatal testicular torsion. ( 27278088 )
2016
50
Seminoma in a Man with Russell-Silver Syndrome Presenting with Testicular Torsion. ( 27034882 )
2016

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

GO Terms for Testicular Torsion

Cellular components related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 ACE CD79A GSR
2 replication fork GO:0005657 8.62 PCNA TP53

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to glucose starvation GO:0042149 9.43 BCL2 TP53
2 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.4 BCL2 TP53
3 B cell proliferation GO:0042100 9.37 BCL2 CD79A
4 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 BCL2 TP53
5 response to gamma radiation GO:0010332 9.26 BCL2 TP53
6 cell aging GO:0007569 9.16 BCL2 TP53
7 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2 TP53
8 cellular response to hypoxia GO:0071456 8.8 BCL2 TP53 TWIST1

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase binding GO:0035035 9.16 PCNA TP53
2 protein phosphatase 2A binding GO:0051721 8.96 BCL2 TP53
3 protease binding GO:0002020 8.8 BCL2 INSL3 TP53

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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