MCID: TST044
MIFTS: 45

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 57 12
Spermatic Cord Torsion 12 44 15 70
Torsion of Testis 12 32
Torsion of Testicular Cord 57
Torsion of Testicle 12

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
male-limited autosomal dominant vs. y-linked


HPO:

31
testicular torsion:
Inheritance autosomal dominant inheritance y-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11996
OMIM® 57 187400
ICD9CM 34 608.2
MeSH 44 D013086
NCIt 50 C26885
SNOMED-CT 67 198046000
ICD10 32 N44 N44.02
MedGen 41 C0037856
UMLS 70 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to anorchia and inguinal hernia. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and PI3K-Akt signaling pathway. The drugs Hormones and Follicle Stimulating Hormone have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and appendix, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 73 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

More information from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 anorchia 30.7 RXFP2 INSL3 CGB5
2 inguinal hernia 30.5 INSL3 AMH ACE
3 male infertility 30.1 TP53 TBPL1 INSL3 EPPIN
4 impotence 30.1 NOS3 EPPIN ACE
5 cryptorchidism, unilateral or bilateral 30.1 RXFP2 INSL3 EPPIN CGB5 AMH
6 infertility 29.9 TBPL1 RXFP2 INSL3 EPPIN AMH
7 testicular cancer 29.9 TP53 RXFP2 INSL3 CGB5 CASP3
8 testicular disease 29.9 TP53 RXFP2 INSL3 EPPIN AMH
9 varicocele 29.7 TP53 NOS3 CASP3 AMH
10 androgen insensitivity syndrome 29.7 RXFP2 INSL3 AMH
11 teratoma 29.6 TP53 CGB5 AMH
12 disorder of sexual development 29.5 RXFP2 INSL3 EPPIN AMH
13 orchitis 10.7
14 ischemia 10.6
15 hydrocele 10.6
16 epididymo-orchitis 10.6
17 purpura 10.3
18 appendicitis 10.3
19 glomerular disease 10.3 CD79A ACE
20 soft tissue sarcoma 10.3 TP53 BCL2
21 vasculitis 10.3
22 suppressor of tumorigenicity 3 10.3 TP53 BCL2
23 bizarre leiomyoma 10.3 TP53 PCNA
24 atrophy of prostate 10.3 TP53 EPPIN
25 adrenal rest tumor 10.3 INSL3 EPPIN
26 lymphosarcoma 10.2 GSR BCL2
27 seminoma 10.2
28 compartment syndrome 10.2
29 arteritic anterior ischemic optic neuropathy 10.2 NOS3 ACE
30 keratocystic odontogenic tumor 10.2 TP53 BCL2
31 neuromuscular disease 10.2
32 breast fibrosarcoma 10.1 GSR CASP3
33 inflammatory myofibroblastic tumor 10.1 TP53 CASP3 BCL2
34 lymphoma, mucosa-associated lymphoid type 10.1 TP53 CD79A BCL2
35 chronic mountain sickness 10.1 NOS3 BCL2
36 extramedullary plasmacytoma 10.1 CD79A BCL2
37 oral cancer 10.1 TP53 PCNA CASP3
38 thrombosis 10.1
39 azoospermia 10.1
40 48,xyyy 10.1
41 retinal ischemia 10.1 PCNA CASP3 BCL2
42 renal artery disease 10.1 NOS3 ACE
43 patella, chondromalacia of 10.1 CD79A ACE
44 neuroblastoma 10.1
45 ovarian serous adenofibroma 10.1 TP53 AMH
46 sexual disorder 10.1 NOS3 EPPIN ACE
47 alopecia 10.1
48 ovarian serous cystadenofibroma 10.0 TP53 AMH
49 retinal vascular disease 10.0 NOS3 CASP3 ACE
50 intracranial aneurysm 10.0 NOS3 CASP3 ACE

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Human phenotypes related to Testicular Torsion:

31
# Description HPO Frequency HPO Source Accession
1 testicular torsion 31 HP:0100813
2 abnormality of the genitourinary system 31 HP:0000119
3 torsion of appendix of testis 31 HP:0033180

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM®:

187400 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Testicular Torsion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.06 ACE AMH BCL2 CASP3 INSL3 NOS3
2 reproductive system MP:0005389 9.77 ACE AMH BCL2 CASP3 INSL3 NOS3
3 neoplasm MP:0002006 9.73 ACE AMH BCL2 CD79A RXFP2 TP53
4 renal/urinary system MP:0005367 9.7 ACE BCL2 CASP3 CD79A NOS3 RXFP2
5 vision/eye MP:0005391 9.23 ACE BCL2 CASP3 GSR NOS3 RXFP2

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 Follicle Stimulating Hormone
3 Androgens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
2 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109
4 Testicular Function After Testicular Torsion Not yet recruiting NCT04137965

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

40
Testis, Testes, Appendix, Prostate, Ovary, Endothelial, Neutrophil

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 2230)
# Title Authors PMID Year
1
Familial torsion of the spermatic cord. 57 61
2908936 1989
2
Neonatal testicular torsion in two brothers. 57 61
1121017 1975
3
Familial occurrence of testicular torsion. 57 61
13718864 1960
4
Familial torsion of the testicle. 57
3986454 1985
5
Spectrum of urological emergencies and surgical interventions in a single tertiary health center. 61
33680746 2021
6
Protective effect of liraglutide on experimental testicular ischaemia reperfusion in rats. 61
33550644 2021
7
Measuring complications of serious pediatric emergencies using ICD-10. 61
33374034 2021
8
Beyond its anti-migraine properties, sumatriptan is an anti-inflammatory agent: A systematic review. 61
33792938 2021
9
MRI-guided conservative management of a left segmental testicular infarction. 61
33598063 2021
10
Amyand's hernia: presumptive diagnosis by CT and literature review. 61
33613803 2021
11
Urological management and surgical procedures in migrants from Sub-Saharan Africa with urogenital schistosomiasis. 61
33685664 2021
12
Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice. 61
33648042 2021
13
Is There Bacterial Growth Inside the Tunica Vaginalis Cavity in Patients With Unsalvageable Testicular Torsion? 61
33278461 2021
14
Testicular torsion in the medicolegal perspective: Why is the diagnosis missing? 61
33630295 2021
15
The Use of Doppler Ultrasound for Suspected Testicular Torsion: Lessons Learned from a 15-Year Multicentre Retrospective Study of 2922 Patients. 61
33663983 2021
16
Boggy pseudomass sonographic sign for testicular torsion. 61
32989554 2021
17
Cryptorchid testicular torsion in children: characteristics and treatment outcomes. 61
33723095 2021
18
[Testicular torsion: Legal aspects to keep in mind. Concepts and tricks.] 61
33650532 2021
19
The effects of pirfenidone on ischaemia-reperfusion injury in testicular torsion-induced rat model. 61
33244780 2021
20
Point-of-care ultrasonography for the diagnosis of testicular torsion: a practical resident curriculum. 61
33739804 2021
21
Serious incidents in testicular torsion management in England, 2007-2019: Optimising individual and training factors are the key to improved outcomes. 61
33783942 2021
22
Testicular torsion: epidemiological risk factors for orchiectomy in pediatric and adult patients. 61
32683416 2021
23
ATPase inhibition by omeprazole reveals role of heat shock proteins on testicular torsion. 61
33368442 2021
24
Management of Testicular Torsion and a Contralateral Testicular Mass Presenting Synchronously. 61
32916189 2021
25
Case of intermittent testicular torsion and de-torsion captured on scrotal ultrasound. 61
32761856 2021
26
Duration of symptoms is the only predictor of testicular salvage following testicular torsion in children: A case-control study. 61
33221112 2021
27
Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats. 61
33733509 2021
28
Segmental Testicular Infarction Associated to Torsion: First Case Report in Childhood. 61
32791290 2021
29
Smartphone Thermal Imaging in the Detection of Testicular Ischemia. 61
33689763 2021
30
Why adolescents delay with presentation to hospital with acute testicular pain: A qualitative study. 61
32828543 2021
31
Urological emergencies in a Nigerian teaching hospital: Epidemiology and treatment. 61
33723115 2021
32
The effects of CoQ10 supplement on matrix metalloproteinases, oxidative DNA damage and pro-inflammatory cytokines in testicular ischaemia/reperfusion injury in rats. 61
33368479 2021
33
Diffusion tensor imaging in evaluating testicular injury after unilateral testicular torsion and detorsion in rat model: A preliminary study. 61
33616285 2021
34
Testicular Torsion in Monorchism Diagnosed with Point-of-care Ultrasound: A Case Report. 61
33560959 2021
35
Did COVID-19 Affect Time to Presentation in the Setting of Pediatric Testicular Torsion? 61
33512891 2021
36
Functional testicular torsion secondary to an incarcerated inguinal hernia in a 4-month old: complete recovery at 18-hours. 61
33628423 2021
37
Management of testicular torsion in the ER: Lessons learned from medical professional liability claims. 61
33581908 2021
38
Impact of treatment delays on outcome of acute testicular torsion: a 15-year retrospective study. 61
33538652 2021
39
A retrospective multicentric analysis on testicular torsion: is there still something to learn? 61
33620015 2021
40
Testicular torsion: its effect on autoimmunisation, pituitary-testis axis and correlation with primary gonadal dysfunction in boys. 61
33603210 2021
41
Impact of hospital transfer on testicular torsion outcomes: A systematic review and meta-analysis. 61
33610457 2021
42
The effect of hypothermia in a rat testicular torsion/detorsion model. 61
33610458 2021
43
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 61
33530122 2021
44
[Scrotal oedema: a urological chameleon]. 61
31067578 2021
45
Anatomical risk factors for spermatic cord torsion and their involvement in the choice of orchidopexy technique. 61
32919902 2021
46
Acute scrotal pain in pediatric patients: diagnosis with an innovative Doppler technique (MicroV). 61
32591921 2021
47
Prenatally Diagnosed Testicular Torsion: A Rare Condition That Causes Dilemma in Management. 61
33532107 2021
48
Establishment and internal validation of preoperative nomograms for predicting the possibility of testicular salvage in patients with testicular torsion. 61
32687070 2021
49
A systematic review on the utility of ultrasonography in the diagnosis of testicular torsion in acute scrotum patients. 61
33451883 2021
50
Pediatric Trauma-Induced Testicular Torsion: A Surgical Emergency. 61
33378756 2021

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

Pathways related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 TP53 PCNA NOS3 CASP3 BCL2 ACE
2
Show member pathways
12.76 TP53 TBPL1 NOS3 CASP3 BCL2
3
Show member pathways
12.04 TP53 NOS3 CASP3 BCL2
4
Show member pathways
11.96 TP53 NOS3 CASP3 BCL2
5 11.85 TP53 PCNA BCL2
6
Show member pathways
11.82 TP53 CASP3 BCL2
7 11.79 TP53 NOS3 BCL2
8 11.72 PGK2 NOS3 BCL2
9 11.7 TP53 PCNA BCL2
10 11.63 NOS3 CASP3 BCL2
11 11.58 NOS3 CASP3 BCL2
12 11.54 TP53 CASP3 BCL2
13 11.3 TP53 CASP3 BCL2
14 10.99 TP53 CASP3 BCL2
15 10.71 TP53 CASP3 BCL2
16 10.2 TP53 CASP3 BCL2

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.56 TP53 CASP3 BCL2 AMH
2 response to oxidative stress GO:0006979 9.54 TP53 PCNA BCL2
3 response to X-ray GO:0010165 9.4 TP53 CASP3
4 hematopoietic stem cell differentiation GO:0060218 9.32 TP53 ACE
5 T cell lineage commitment GO:0002360 9.16 TP53 BCL2
6 B cell lineage commitment GO:0002326 8.96 TP53 BCL2
7 neuron apoptotic process GO:0051402 8.8 TP53 CASP3 BCL2

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 INSL3 CGB5 AMH
2 protease binding GO:0002020 8.92 TP53 INSL3 CASP3 BCL2

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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