MCID: TST044
MIFTS: 49

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 57 12
Spermatic Cord Torsion 12 44 15 72
Torsion of Testis 12 33
Torsion of Testicular Cord 57
Torsion of Testicle 12

Characteristics:

OMIM:

57
Inheritance:
male-limited autosomal dominant vs. y-linked


HPO:

32
testicular torsion:
Inheritance autosomal dominant inheritance y-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11996
OMIM 57 187400
ICD9CM 35 608.2 608.20
MeSH 44 D013086
NCIt 50 C26885
SNOMED-CT 68 49198006 81996005
MedGen 42 C0037856
UMLS 72 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to ischemia and teratoma. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drugs Resveratrol and Methylcobalamin have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and appendix, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 75 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

More information from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 ischemia 29.6 NOS3 CASP3 BCL2 ACE
2 teratoma 11.7
3 orchitis 10.6
4 hydrocele 10.6
5 epididymo-orchitis 10.5
6 infertility 10.5
7 anterolateral myocardial infarction 10.4 CHKB ACE
8 hypersensitivity vasculitis 10.4 CD79A ACE
9 cryptorchidism, unilateral or bilateral 10.4
10 purpura 10.3
11 anorchia 10.3
12 inguinal hernia 10.3
13 vasculitis 10.3
14 male infertility 10.3
15 appendicitis 10.3
16 marek disease 10.2 TP53 ACE
17 syphilis 10.2 CD79A BCL2
18 testicular disease 10.2
19 seminoma 10.2
20 malignant teratoma 10.2 TP53 BCL2
21 cervical carcinosarcoma 10.2 TP53 BCL2
22 neuromuscular disease 10.2
23 compartment syndrome 10.2
24 lymphosarcoma 10.2 GSR CD79A
25 soft tissue sarcoma 10.2 TP53 BCL2
26 ulcerative stomatitis 10.1 TP53 CD79A
27 optic nerve neoplasm 10.1 TP53 ACE
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
29 varicocele 10.1
30 acute cystitis 10.1
31 hidradenocarcinoma 10.1 TP53 BCL2
32 focal cortical dysplasia, type ii 10.1 TP53 BCL2
33 alopecia 10.1
34 short-rib thoracic dysplasia 4 with or without polydactyly 10.0 TP53 CASP3
35 keratocystic odontogenic tumor 10.0 TP53 BCL2
36 neuroblastoma 1 10.0
37 renal artery disease 10.0 NOS3 ACE
38 vasculogenic impotence 10.0 NOS3 ACE
39 epidermoid cysts 10.0
40 azoospermia 10.0
41 pyuria 10.0
42 hypogonadism 10.0
43 cerebral palsy 10.0
44 hemangioma 10.0
45 testicular cancer 10.0
46 cavernous hemangioma 10.0
47 hypogonadotropism 10.0
48 48,xyyy 10.0
49 mature teratoma 10.0 TP53 PCNA
50 oral leukoplakia 10.0 TP53 PCNA

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Human phenotypes related to Testicular Torsion:

32
# Description HPO Frequency HPO Source Accession
1 testicular torsion 32 HP:0100813
2 abnormality of the genitourinary system 32 HP:0000119

Symptoms via clinical synopsis from OMIM:

57
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM:

187400

GenomeRNAi Phenotypes related to Testicular Torsion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 ACE BCL2 CASP3 PCNA TP53
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 ACE BCL2 CASP3 PCNA TP53

MGI Mouse Phenotypes related to Testicular Torsion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ACE BCL2 CASP3 CHKB INSL3 NOS3
2 endocrine/exocrine gland MP:0005379 9.87 ACE BCL2 CASP3 INSL3 NOS3 PCNA
3 adipose tissue MP:0005375 9.8 ACE BCL2 NOS3 PCNA TP53
4 hematopoietic system MP:0005397 9.8 ACE BCL2 CASP3 CD79A NOS3 PCNA
5 immune system MP:0005387 9.7 ACE BCL2 CASP3 CD79A NOS3 PCNA
6 renal/urinary system MP:0005367 9.43 ACE BCL2 CASP3 CD79A NOS3 TP53
7 reproductive system MP:0005389 9.17 ACE BCL2 CASP3 INSL3 NOS3 PCNA

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Resveratrol Approved, Experimental, Investigational 501-36-0 445154
2
Methylcobalamin Approved, Experimental, Investigational 13422-55-4
3
leucovorin Approved 58-05-9 143 6006
4
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
5
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
6
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
7
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
8
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved 65-23-6 1054
9
Cobalamin Experimental 13408-78-1 6857388
10 Catalase
11 Antioxidants
12 Protective Agents
13 Androgens
14 Hormones
15 Follicle Stimulating Hormone
16 Micronutrients
17 Hematinics
18 Vitamins
19 Vitamin B 12
20 Vitamin B Complex
21 Vitamin B9
22 Vitamin B 6
23 Nutrients
24 Folate
25 Vitamin B12
26 Trace Elements
27 Calciferol
28 Bone Density Conservation Agents
29
Pyridoxal Experimental, Nutraceutical 66-72-8 1050

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
2 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109
3 Oxidative Stress in Testicular Tissue Before and After Cryopreservation Completed NCT03621995
4 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575
5 Evaluation of Treatment With Trans-resveratrol, Folic Acid, Vitamin D, Vitamin B12 and B6 in Men With Infertility Recruiting NCT03864198
6 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Not yet recruiting NCT03969979

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

41
Testis, Testes, Appendix, Neutrophil, Ovary, Endothelial, Bone

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 2020)
# Title Authors PMID Year
1
Familial torsion of the spermatic cord. 38 8
2908936 1989
2
Neonatal testicular torsion in two brothers. 38 8
1121017 1975
3
Familial occurrence of testicular torsion. 38 8
13718864 1960
4
Familial torsion of the testicle. 8
3986454 1985
5
Spermatogenesis Recovery Potentials after Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cells Cultured with Growth Factors in Experimental Azoospermic Mouse Models. 38
31376321 2020
6
Door To Detorsion time determine testicular survival. 38
31408640 2019
7
Complications of Serious Pediatric Conditions in the Emergency Department: Definitions, Prevalence, and Resource Utilization. 38
31383471 2019
8
Isolated Spermatic Vein Thrombosis. 38
31358105 2019
9
Protective effects of sumatriptan on ischaemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes of rat. 38
31286549 2019
10
Primary gonadal failure. 38
31327696 2019
11
Testicular torsion. 38
31308008 2019
12
Optimal Predictor of Gonadal Viability in Testicular Torsion: Time to Treat Versus Duration of Symptoms. 38
31357158 2019
13
Protective effects of colchicine on testicular torsion/detorsion-induced ischemia/reperfusion injury in rats. 38
31364099 2019
14
Whole-Exome Sequencing Identifies Novel Heterozygous Mutation in RAF1 in Family With Neonatal Testicular Torsion. 38
30904638 2019
15
Does the source of referral affect outcomes for paediatric testicular torsion? 38
31155886 2019
16
Can haematologic parameters be used to predict testicular viability in testicular torsion? 38
31264256 2019
17
The role of ultrasound imaging in adult patients with testicular torsion: a systematic review and meta-analysis. 38
30847624 2019
18
Diagnostic Accuracy of Ultrasound for the Directionality of Testicular Rotation and the Degree of Spermatic Cord Twist in Pediatric Patients With Testicular Torsion. 38
31268182 2019
19
Comparison of multiple doses of cyclosporine A on germ cell apoptosis and epididymal sperm parameters after testicular ischemia/reperfusion in rats. 38
31251898 2019
20
Torsion of an Undescended Testis - A Surgical Pediatric Emergency. 38
31272681 2019
21
Which agent should be used to reduce ischemia-reperfusion injury after testicular torsion: a comparative animal experiment. 38
31288984 2019
22
Testicular torsion and reperfusion: Germ cell DNA damage and development. 38
30746737 2019
23
Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord. 38
31115365 2019
24
[Scrotal oedema: a urological chameleon]. 38
31067578 2019
25
N-acetylcysteine protects testicular tissue against ischemia/reperfusion injury via inhibiting endoplasmic reticulum stress and apoptosis. 38
30890312 2019
26
Scrotal Ultrasound. 38
30928082 2019
27
Pediatric testicular torsion: does patient transfer affect time to intervention or surgical outcomes at a rural tertiary care center? 38
31101044 2019
28
Identifying systems delays in assessment, diagnosis, and operative management for testicular torsion in a single-payer health-care system. 38
31005635 2019
29
Ischemia Modified Albumin and D-dimer in the Diagnosis of Testicular Torsion: an Experimental Model. 38
31119719 2019
30
Re-presentations and recurrent events following initial management of the acute paediatric scrotum: a 5-year review. 38
28239996 2019
31
Treatment with estrogen receptor agonist ERβ improves torsion-induced oxidative testis injury in rats. 38
30825546 2019
32
Controversies in the management of neonatal testicular torsion: A meta-analysis. 38
30098810 2019
33
Do repeat ultrasounds affect orchiectomy rate in patients with testicular torsion treated at a pediatric institution? 38
30704855 2019
34
[Clinical features of testicular torsion and its misdiagnosis:analysis of 274 cases]. 38
31068295 2019
35
Point-of-care influences orchiectomy rates in pediatric patients with testicular torsion. 38
31130503 2019
36
The Impact of Testicular Torsion on Testicular Function. 38
31081295 2019
37
Tension hydrocele as an additional cause of acute scrotum: case series and literature review. 38
30929051 2019
38
Simultaneous Testicular and Appendix Testis Torsion: A Novel Clinically Relevant Association. 38
30839439 2019
39
Testicular Torsion Postorchiopexy: A Case of Twisted Hammock. 38
30611657 2019
40
Mean Platelet Volume and Testicular Torsion: New Findings. 38
30091128 2019
41
Remote ischemic conditioning in a rat model of testicular torsion: does it offer testicular protection? 38
30502312 2019
42
Predictive value of hematological parameters in testicular torsion: retrospective investigation of data from a high-volume tertiary care center. 38
30453814 2019
43
Optimal Management of Undescended Testis in Boys with Cerebral Palsy. A Debate. 38
30703771 2019
44
Detection of insulin-like growth factor receptor-1 in the human cremaster muscle and its role in the etiology of the undescended testis. 38
29615365 2019
45
Sneeze and pop: a ruptured varicocele; analysis of literature, guided by a well-documented case-report. 38
30704438 2019
46
Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model. 38
31338145 2019
47
Parents' awareness and knowledge of testicular torsion: A cross-sectional study. 38
30787572 2019
48
Neutrophil-Lymphocyte Ratio Predicts Organ Salvage in Testicular Torsion with Marginal Diagnostic Delay. 38
30584993 2019
49
[Manual detorsion and elective orchiopexy as an alternative treatment for acute testicular torsion in children]. 38
30714696 2019
50
Testicular granulomatous vasculitis mimicking testicular torsion in an anti-neutrophil cytoplasmic antibody-associated vasculitis patient. 38
30719308 2019

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

Pathways related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 TP53 NOS3 CASP3 BCL2
2
Show member pathways
12.63 TP53 PCNA CASP3 BCL2
3
Show member pathways
12.43 TP53 PCNA CASP3 BCL2
4
Show member pathways
12.43 TP53 NOS3 CASP3 BCL2
5
Show member pathways
12.17 TP53 CASP3 BCL2
6
Show member pathways
12.02 TP53 CASP3 BCL2
7
Show member pathways
12 TP53 CASP3 BCL2
8 11.92 TP53 CASP3 BCL2
9 11.91 TP53 CASP3 BCL2
10 11.86 TP53 NOS3 BCL2
11 11.81 TP53 PCNA BCL2
12
Show member pathways
11.75 TP53 CASP3 BCL2
13 11.71 TP53 NOS3 BCL2
14
Show member pathways
11.68 TP53 NOS3 CASP3 BCL2
15
Show member pathways
11.67 TP53 CASP3 BCL2
16 11.61 TP53 PCNA BCL2
17 11.54 NOS3 CASP3 BCL2
18 11.46 TP53 CASP3 BCL2
19 11.4 NOS3 CASP3 BCL2
20
Show member pathways
11.24 TP53 NOS3
21 11.23 CASP3 BCL2
22 11.2 TP53 CASP3 BCL2
23 11.16 CASP3 BCL2
24 11.12 TP53 PCNA
25 11.11 CASP3 BCL2
26 11.06 TP53 PCNA
27 10.94 CASP3 BCL2
28
Show member pathways
10.9 TP53 BCL2
29 10.46 TP53 CASP3 BCL2

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to organic substance GO:0071310 9.57 CASP3 BCL2
2 cellular response to glucose starvation GO:0042149 9.56 TP53 BCL2
3 response to nicotine GO:0035094 9.55 CASP3 BCL2
4 neuron apoptotic process GO:0051402 9.54 CASP3 BCL2
5 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.52 TP53 BCL2
6 B cell proliferation GO:0042100 9.51 CD79A BCL2
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.49 CASP3 BCL2
8 blood vessel remodeling GO:0001974 9.48 NOS3 ACE
9 response to antibiotic GO:0046677 9.46 TP53 CASP3
10 homeostasis of number of cells within a tissue GO:0048873 9.43 NOS3 BCL2
11 response to gamma radiation GO:0010332 9.4 TP53 BCL2
12 T cell homeostasis GO:0043029 9.37 CASP3 BCL2
13 cell aging GO:0007569 9.32 TP53 BCL2
14 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.26 TP53 BCL2
15 cellular response to DNA damage stimulus GO:0006974 9.26 TP53 PCNA CASP3 BCL2
16 B cell homeostasis GO:0001782 9.16 CASP3 BCL2
17 regulation of mitochondrial membrane permeability GO:0046902 8.62 TP53 BCL2

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.26 NOS3 GSR
2 protein phosphatase 2A binding GO:0051721 9.16 TP53 BCL2
3 histone acetyltransferase binding GO:0035035 8.96 TP53 PCNA
4 protease binding GO:0002020 8.92 TP53 INSL3 CASP3 BCL2

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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