MCID: TST044
MIFTS: 47

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Torsion

MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 56 12
Spermatic Cord Torsion 12 43 15 71
Torsion of Testis 12 32
Torsion of Testicular Cord 56
Torsion of Testicle 12

Characteristics:

OMIM:

56
Inheritance:
male-limited autosomal dominant vs. y-linked


HPO:

31
testicular torsion:
Inheritance autosomal dominant inheritance y-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11996
OMIM 56 187400
ICD9CM 34 608.2 608.20
MeSH 43 D013086
NCIt 49 C26885
SNOMED-CT 67 49198006 81996005
MedGen 41 C0037856
SNOMED-CT via HPO 68 263681008 287085006 42030000
UMLS 71 C0037856

Summaries for Testicular Torsion

MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to anorchia and cryptorchidism, unilateral or bilateral. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Apoptosis Pathway and Activation of BH3-only proteins. The drugs Methylcobalamin and Resveratrol have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 74 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

More information from OMIM: 187400

Related Diseases for Testicular Torsion

Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 anorchia 30.7 RXFP2 INSL3 CGB5
2 cryptorchidism, unilateral or bilateral 30.4 RXFP2 INSL3 EPPIN CGB5
3 testicular disease 30.2 TP53 RXFP2 INSL3 EPPIN
4 testicular cancer 29.9 TP53 RXFP2 INSL3 CGB5
5 ischemia 29.6 TP53 NOS3 CAT CASP3 BCL2 ACE
6 varicocele 29.6 TP53 NOS3 CAT CASP3
7 teratoma 11.7
8 orchitis 10.6
9 hydrocele 10.6
10 epididymo-orchitis 10.6
11 infertility 10.5
12 actinic cheilitis 10.5 TP53 BCL2
13 marek disease 10.5 TP53 ACE
14 soft tissue sarcoma 10.4 TP53 BCL2
15 suppressor of tumorigenicity 3 10.4 TP53 BCL2
16 glomerular disease 10.4 CD79A ACE
17 anterolateral myocardial infarction 10.4 CHKB ACE
18 iga nephropathy 1 10.4 CD79A ACE
19 bizarre leiomyoma 10.4 TP53 PCNA
20 atrophy of prostate 10.4 TP53 EPPIN
21 inguinal hernia 10.3
22 purpura 10.3
23 lymphosarcoma 10.3 GSR BCL2
24 adrenal rest tumor 10.3 INSL3 EPPIN
25 oral leukoplakia 10.3 TP53 PCNA
26 vasculitis 10.3
27 male infertility 10.3
28 appendicitis 10.3
29 seminoma 10.2
30 gastric lymphoma 10.2 TP53 PCNA CD79A
31 chronic mountain sickness 10.2 NOS3 BCL2
32 neuromuscular disease 10.2
33 compartment syndrome 10.2
34 lymphoma, mucosa-associated lymphoid type 10.2 TP53 CD79A BCL2
35 inflammatory myofibroblastic tumor 10.2 TP53 CASP3 BCL2
36 extramedullary plasmacytoma 10.1 CD79A BCL2
37 kidney hypertrophy 10.1 NOS3 ACE
38 oral cancer 10.1 TP53 PCNA CASP3
39 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
40 acute cystitis 10.1
41 alopecia 10.1
42 sexual disorder 10.1 NOS3 EPPIN ACE
43 peripheral vascular disease 10.1 TP53 NOS3 ACE
44 uterine carcinosarcoma 10.1 TP53 PCNA BCL2
45 neuroblastoma 10.0
46 retinal vascular disease 10.0 NOS3 CASP3 ACE
47 epidermoid cysts 10.0
48 azoospermia 10.0
49 pyuria 10.0
50 impotence 10.0

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion

Symptoms & Phenotypes for Testicular Torsion

Human phenotypes related to Testicular Torsion:

31
# Description HPO Frequency HPO Source Accession
1 testicular torsion 31 HP:0100813
2 abnormality of the genitourinary system 31 HP:0000119

Symptoms via clinical synopsis from OMIM:

56
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM:

187400

MGI Mouse Phenotypes related to Testicular Torsion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 ACE BCL2 CASP3 CD79A DNTT NOS3
2 neoplasm MP:0002006 9.63 ACE BCL2 CAT CD79A RXFP2 TP53
3 renal/urinary system MP:0005367 9.5 ACE BCL2 CASP3 CD79A NOS3 RXFP2
4 reproductive system MP:0005389 9.28 ACE BCL2 CASP3 INSL3 NOS3 PCNA

Drugs & Therapeutics for Testicular Torsion

Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylcobalamin Approved, Investigational 13422-55-4
2
Resveratrol Approved, Experimental, Investigational 501-36-0 445154
3
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
4
leucovorin Approved 58-05-9 6006 143
5
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
6
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
7
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved 65-23-6 1054
8
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
9
Cobalamin Experimental 13408-78-1 6857388
10 Estrogens
11 Hormone Antagonists
12 Hormones
13 Androgens
14 Follicle Stimulating Hormone
15 Catalase
16 Antioxidants
17 Protective Agents
18 Vitamins
19 Micronutrients
20 Hematinics
21 Trace Elements
22 Vitamin B 12
23 Nutrients
24 Vitamin B9
25 Vitamin B 6
26 Vitamin B Complex
27 Vitamin B12
28 Folate
29 Calciferol
30
Pyridoxal Experimental, Nutraceutical 66-72-8 1050

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
2 Odense Androgen Study – A Population-Based Study of Androgens, Body Composition, and Muscle Function in 20-29 Year-Old Danish Men Unknown status NCT00150163
3 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
4 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109
5 Oxidative Stress in Testicular Tissue Before and After Cryopreservation Completed NCT03621995
6 Assesment of the Testicular Effects of Epididymo-orchitis in Boys Via Elastograpy Recruiting NCT03969979
7 Evaluation of Treatment With Trans-resveratrol, Folic Acid, Vitamin D, Vitamin B12 and B6 in Men With Infertility Recruiting NCT03864198
8 Testicular Function After Testicular Torsion Not yet recruiting NCT04137965

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Testicular Torsion

Anatomical Context for Testicular Torsion

MalaCards organs/tissues related to Testicular Torsion:

40
Testis, Testes, Prostate, Appendix, Neutrophil, Kidney, Breast

Publications for Testicular Torsion

Articles related to Testicular Torsion:

(show top 50) (show all 2083)
# Title Authors PMID Year
1
Familial torsion of the spermatic cord. 61 56
2908936 1989
2
Neonatal testicular torsion in two brothers. 61 56
1121017 1975
3
Familial occurrence of testicular torsion. 61 56
13718864 1960
4
Familial torsion of the testicle. 56
3986454 1985
5
Predictive value of ischaemia-modified albumin in spermatogenesis in an experimental testicular torsion model. 61
31691325 2020
6
Predictive value of haematologic parameters in diagnosis of testicular torsion: Evidence from a systematic review and meta-analysis. 61
31782182 2020
7
The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats. 61
31713254 2020
8
Torsion of the testis with perineal ectopy. 61
31890594 2020
9
Metformin decreases testicular damages following ischaemia/reperfusion injury in rats. 61
31815318 2020
10
Investigating the sperm parameters, oxidative stress and histopathological effects of salvia miltiorrhiza hydroalcoholic extract in the prevention of testicular ischemia reperfusion damage in rats. 61
31927420 2020
11
Prognosis of testicular torsion orchiopexy. 61
31713875 2020
12
Testicular Loss in Children Due to Incorrect Early Diagnosis of Torsion. 61
32019340 2020
13
Testicular torsion treatment: the horns of a dilemma? 61
31755741 2020
14
Use of intraoperative Indocyanine green fluorescence to assess testicular perfusion and viability when managing testicular torsion in a 26-year old man. 61
31754602 2020
15
Diagnostic Accuracy of Ultrasound for the Directionality of Testicular Rotation and the Degree of Spermatic Cord Twist in Pediatric Patients With Testicular Torsion. 61
31268182 2020
16
Acute scrotum in elderly; is it torsion ! 61
31709147 2020
17
Witnessed Torsion in Extremely Premature Newborns: 2 Cases of Testicular Salvage in the NICU. 61
31568794 2020
18
Epididymal polar dissociation: A rare entity. 61
31641603 2020
19
Modified stepwise mini-incision microdissection testicular sperm extraction: a useful technique for patients with a history of orchidopexy affected by non-obstructive azoospermia. 61
31898445 2020
20
Spermatogenesis Recovery Potentials after Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cells Cultured with Growth Factors in Experimental Azoospermic Mouse Models. 61
31376321 2020
21
Torsion of undescended abdominal testicle in a 16-year-old and its management. 61
32001538 2020
22
Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord. 61
31115365 2020
23
Testicular Pain Pathway in Children: Investigating Where Missed Torsion Occurs Most Often. 61
31977775 2020
24
Effects of nalmefene hydrochloride on TLR4 signaling pathway in rats with lung ischemia-reperfusion injury. 61
31957861 2020
25
Using the World Society of Emergency Surgery (WSES) Triage Tool to Evaluate Timing of Emergency Surgery in Rwanda. 61
31933043 2020
26
Comparison of the effects of intermittent reperfusion and hypothermia in preventing testicular ischemia-reperfusion injury in the testicular torsion model in rats. 61
31630934 2019
27
Which agent should be used to reduce ischemia-reperfusion injury after testicular torsion: a comparative animal experiment. 61
31288984 2019
28
Effect of ethyl pyruvate on oxidative state and endoplasmic reticulum stress in a rat model of testicular torsion. 61
31850805 2019
29
A comparison of clinical outcomes of acute testicular torsion between prepubertal and postpubertal males. 61
31690483 2019
30
Accuracy of point-of-care ultrasound by pediatric emergency physicians for testicular torsion. 61
31455581 2019
31
Protective effects of modafinil administration on testicular torsion/detorsion damage in rats. 61
31491367 2019
32
Sutured point-fixation versus Jaboulay fixation for salvaged testicular torsion in children. 61
31522800 2019
33
An unusual presentation of testicular torsion in children: a single - centre retrospective study. 61
31860419 2019
34
Ischemia Modified Albumin and D-dimer in the Diagnosis of Testicular Torsion: An Experimental Model. 61
31119719 2019
35
Optimal Predictor of Gonadal Viability in Testicular Torsion: Time to Treat Versus Duration of Symptoms. 61
31357158 2019
36
Management of testicular torsion <360° in children: a single-center, retrospective study. 61
31891289 2019
37
Testicular Torsion Pain Honeymoons. 61
28926509 2019
38
A Systematic Review of Testicle Survival Time After a Torsion Event. 61
28953100 2019
39
Automated electronic discharge summary for patients undergoing acute scrotal exploration: does it improve accuracy and quality? 61
31439431 2019
40
Clinical state of the paediatric acute scrotum in south-eastern Victoria. 61
31508881 2019
41
Beneficial effects of dapsone on ischemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes in rat. 61
31473496 2019
42
Acute Scrotal Emergencies. 61
31563197 2019
43
Case 2: Chronic Testicular Torsion in a Healthy Neonate. 61
31676742 2019
44
Prevention of the harmful effects of free oxygen radicals by using N-acetylcysteine in testicular torsion. 61
31882389 2019
45
Effect of Pediatric Testicular Torsion on Testicular Function in the Short Term. 61
31718871 2019
46
Acute scrotum and testicular torsion in children: a retrospective study in a single institution. 61
31874735 2019
47
A Retrospective Analysis of Intervention for Testicular Torsion: Searching for a Hallmark of High Reliability. 61
32010858 2019
48
Protective effect of dipeptidyl peptidase-4 inhibitors in testicular torsion/detorsion in rats: a possible role of HIF-1α and nitric oxide. 61
31773182 2019
49
Complications of Serious Pediatric Conditions in the Emergency Department: Definitions, Prevalence, and Resource Utilization. 61
31383471 2019
50
Conservative Management of Scrotal Hematoma Secondary to Adrenal Hemorrhage in Newborns. 61
31465793 2019

Variations for Testicular Torsion

Expression for Testicular Torsion

Search GEO for disease gene expression data for Testicular Torsion.

Pathways for Testicular Torsion

Pathways related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 TP53 NOS3 CASP3 BCL2
2
Show member pathways
11.79 TP53 CASP3 BCL2
3 11.76 TP53 NOS3 BCL2
4 11.73 TP53 CAT BCL2
5 11.69 PGK2 NOS3 BCL2
6 11.66 TP53 PCNA BCL2
7 11.61 NOS3 CASP3 BCL2
8 11.55 NOS3 CASP3 BCL2
9 11.51 TP53 CASP3 BCL2
10 11.3 TP53 CASP3 BCL2
11 10.99 TP53 CASP3 BCL2
12
Show member pathways
10.98 TP53 CAT CASP3 BCL2
13
Show member pathways
10.73 TP53 NOS3 CAT

GO Terms for Testicular Torsion

Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.81 TP53 CAT CASP3 BCL2
2 negative regulation of apoptotic process GO:0043066 9.8 TP53 RXFP2 CAT CASP3 BCL2
3 kidney development GO:0001822 9.72 CAT BCL2 ACE
4 response to estradiol GO:0032355 9.7 PCNA CAT CASP3
5 protein homotetramerization GO:0051289 9.61 TP53 CD79A CAT
6 response to metal ion GO:0010038 9.56 TP53 CASP3
7 response to hyperoxia GO:0055093 9.54 TP53 CAT
8 response to hydrogen peroxide GO:0042542 9.5 CAT CASP3 BCL2
9 hematopoietic stem cell differentiation GO:0060218 9.49 TP53 ACE
10 regulation of mitochondrial membrane permeability GO:0046902 9.48 TP53 BCL2
11 response to UV-B GO:0010224 9.46 TP53 BCL2
12 T cell lineage commitment GO:0002360 9.37 TP53 BCL2
13 response to UV GO:0009411 9.33 TP53 CAT CASP3
14 B cell lineage commitment GO:0002326 9.26 TP53 BCL2
15 neuron apoptotic process GO:0051402 9.13 TP53 CASP3 BCL2
16 response to oxidative stress GO:0006979 8.92 TP53 PCNA CAT BCL2

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.13 NOS3 GSR CAT
2 protease binding GO:0002020 8.92 TP53 INSL3 CASP3 BCL2

Sources for Testicular Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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