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MCID: TST044
MIFTS: 45

Testicular Torsion

Categories: Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Testicular Torsion

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MalaCards integrated aliases for Testicular Torsion:

Name: Testicular Torsion 57 12
Spermatic Cord Torsion 12 44 15 71
Torsion of Testis 12 32
Torsion of Testicular Cord 57
Torsion of Testicle 12

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
male-limited autosomal dominant vs. y-linked


HPO:

31
testicular torsion:
Inheritance autosomal dominant inheritance y-linked inheritance


Classifications:

MalaCards categories:
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11996
OMIM® 57 187400
ICD9CM 34 608.2
MeSH 44 D013086
NCIt 50 C26885
SNOMED-CT 67 198046000
ICD10 32 N44 N44.02
MedGen 41 C0037856
UMLS 71 C0037856
Sources

Summaries for Testicular Torsion

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MalaCards based summary : Testicular Torsion, also known as spermatic cord torsion, is related to anorchia and cryptorchidism, unilateral or bilateral. An important gene associated with Testicular Torsion is INSL3 (Insulin Like 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Apoptosis Pathway. The drugs Hormones and Follicle Stimulating Hormone have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and appendix, and related phenotypes are testicular torsion and abnormality of the genitourinary system

Wikipedia : 74 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

More information from OMIM: 187400
Sources

Related Diseases for Testicular Torsion

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Diseases related to Testicular Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 anorchia 30.7 RXFP2 INSL3 CGB5
2 cryptorchidism, unilateral or bilateral 30.5 RXFP2 INSL3 EPPIN CGB5
3 testicular disease 30.3 TP53 RXFP2 INSL3 EPPIN
4 varicocele 30.2 TP53 NOS3 CASP3
5 impotence 30.1 NOS3 EPPIN ACE
6 disorder of sexual development 29.9 RXFP2 INSL3 EPPIN
7 testicular cancer 29.9 TP53 RXFP2 INSL3 CGB5 CASP3
8 male infertility 29.6 TP53 TBPL1 RXFP2 NOS3 INSL3 EPPIN
9 orchitis 10.6
10 ischemia 10.6
11 hydrocele 10.6
12 epididymo-orchitis 10.5
13 infertility 10.5
14 inguinal hernia 10.3
15 purpura 10.3
16 appendicitis 10.3
17 vasculitis 10.3
18 glomerular disease 10.3 CD79A ACE
19 soft tissue sarcoma 10.3 TP53 BCL2
20 suppressor of tumorigenicity 3 10.3 TP53 BCL2
21 atrophy of prostate 10.3 TP53 EPPIN
22 bizarre leiomyoma 10.3 TP53 PCNA
23 lymphosarcoma 10.2 GSR BCL2
24 adrenal rest tumor 10.2 INSL3 EPPIN
25 seminoma 10.2
26 compartment syndrome 10.2
27 arteritic anterior ischemic optic neuropathy 10.2 NOS3 ACE
28 breast fibrosarcoma 10.2 GSR CASP3
29 syphilis 10.2 CD79A BCL2 ACE
30 gastric lymphoma 10.2 TP53 PCNA BCL2
31 keratocystic odontogenic tumor 10.2 TP53 BCL2
32 ovarian benign neoplasm 10.2 TP53 EPPIN
33 neuromuscular disease 10.2
34 chronic mountain sickness 10.1 NOS3 BCL2
35 renal artery disease 10.1 NOS3 ACE
36 inflammatory myofibroblastic tumor 10.1 TP53 CASP3 BCL2
37 extramedullary plasmacytoma 10.1 CD79A BCL2
38 pelvic varices 10.1 INSL3 EPPIN CASP3
39 lymphoma, mucosa-associated lymphoid type 10.1 TP53 CD79A BCL2
40 oral cancer 10.1 TP53 PCNA CASP3
41 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
42 thrombosis 10.1
43 azoospermia 10.1
44 48,xyyy 10.1
45 retinal ischemia 10.1 PCNA CASP3 BCL2
46 patella, chondromalacia of 10.1 CD79A ACE
47 neuroblastoma 10.1
48 alopecia 10.1
49 sexual disorder 10.1 NOS3 EPPIN ACE
50 malignant ovarian surface epithelial-stromal neoplasm 10.0 TP53 EPPIN CASP3

Graphical network of the top 20 diseases related to Testicular Torsion:



Diseases related to Testicular Torsion
Sources

Symptoms & Phenotypes for Testicular Torsion

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Human phenotypes related to Testicular Torsion:

31
# Description HPO Frequency HPO Source Accession
1 testicular torsion 31 HP:0100813
2 abnormality of the genitourinary system 31 HP:0000119
3 torsion of appendix of testis 31 HP:0033180

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
G U:
testicular torsion
hypermobility of testicle

Clinical features from OMIM®:

187400 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Testicular Torsion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 ADGRB1 CASP3
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 ACE ADGRB1 CASP3 PCNA TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.28 PCNA TP53

MGI Mouse Phenotypes related to Testicular Torsion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 ACE BCL2 CASP3 INSL3 NOS3 PCNA
2 hematopoietic system MP:0005397 10.02 ACE ADGRB1 BCL2 CASP3 CD79A NOS3
3 nervous system MP:0003631 9.96 ACE ADGRB1 BCL2 CASP3 CD79A NOS3
4 reproductive system MP:0005389 9.73 ACE BCL2 CASP3 INSL3 NOS3 PCNA
5 renal/urinary system MP:0005367 9.7 ACE BCL2 CASP3 CD79A NOS3 RXFP2
6 vision/eye MP:0005391 9.23 ACE BCL2 CASP3 GSR NOS3 RXFP2
Sources

Drugs & Therapeutics for Testicular Torsion

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Drugs for Testicular Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 Follicle Stimulating Hormone
3 Androgens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
2 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109
4 Testicular Function After Testicular Torsion Not yet recruiting NCT04137965

Search NIH Clinical Center for Testicular Torsion

Cochrane evidence based reviews: spermatic cord torsion

Sources

Genetic Tests for Testicular Torsion

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Anatomical Context for Testicular Torsion

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MalaCards organs/tissues related to Testicular Torsion:

40
Testis, Testes, Appendix, Ovary, Endothelial, Neutrophil, Thyroid
Sources

Publications for Testicular Torsion

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Articles related to Testicular Torsion:

(show top 50) (show all 2204)
# Title Authors PMID Year
1
Familial torsion of the spermatic cord. 57 61
2908936 1989
2
Neonatal testicular torsion in two brothers. 57 61
1121017 1975
3
Familial occurrence of testicular torsion. 57 61
13718864 1960
4
Familial torsion of the testicle. 57
3986454 1985
5
MRI-guided conservative management of a left segmental testicular infarction. 61
33598063 2021
6
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 61
33530122 2021
7
Protective effect of liraglutide on experimental testicular ischaemia reperfusion in rats. 61
33550644 2021
8
[Scrotal oedema: a urological chameleon]. 61
31067578 2021
9
Testicular torsion: its effect on autoimmunisation, pituitary-testis axis and correlation with primary gonadal dysfunction in boys. 61
33603210 2021
10
Testicular Torsion in Monorchism Diagnosed with Point-of-care Ultrasound: A Case Report. 61
33560959 2021
11
Management of testicular torsion in the ER: Lessons learned from medical professional liability claims. 61
33581908 2021
12
Impact of treatment delays on outcome of acute testicular torsion: a 15-year retrospective study. 61
33538652 2021
13
Did COVID-19 Affect Time to Presentation in the Setting of Pediatric Testicular Torsion? 61
33512891 2021
14
Anatomical risk factors for spermatic cord torsion and their involvement in the choice of orchidopexy technique. 61
32919902 2021
15
Acute scrotal pain in pediatric patients: diagnosis with an innovative Doppler technique (MicroV). 61
32591921 2021
16
Establishment and internal validation of preoperative nomograms for predicting the possibility of testicular salvage in patients with testicular torsion. 61
32687070 2021
17
Perinatal testicular torsion. 61
33277134 2021
18
Intratesticular Human Adipose-Derived Stem Cell (hADSC) Transplantation Decreased Oxidative Stress in Testicular Torsion Model of Wistar Rat. 61
33442548 2021
19
A systematic review on the utility of ultrasonography in the diagnosis of testicular torsion in acute scrotum patients. 61
33451883 2021
20
Consideration of Testicular Torsion in Young Males With Abdominal Pain Is Essential: A Case Review. 61
33187720 2021
21
Testicular Torsion From Bell-clapper Deformity. 61
32650017 2021
22
Effects of platelet-rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model. 61
32866352 2021
23
Effect of a Freezing Medium Containing Melatonin on Markers of Pre-meiotic and Post-meiotic Spermatogonial Stem Cells (SSCs) After Transplantation in an Azoospermia Mouse Model Due to Testicular Torsion. 61
33481217 2021
24
Prenatally Diagnosed Testicular Torsion: A Rare Condition That Causes Dilemma in Management. 61
33532107 2021
25
Validation of the TWIST score for testicular torsion in adults. 61
32844355 2021
26
A retroperitoneal mass presenting as acute scrotum: a rare presentation and review of the literature. 61
33505662 2021
27
Administration of Dexmedetomidine Does Not Produce Long-Term Protective Effect on Testicular Damage Post Testicular Ischemia-Reperfusion Injury. 61
33536744 2021
28
The effect of taxifolin on experimental testicular ischaemia reperfusion injury in rats. A biochemical and histopathological analysis. 61
33531214 2021
29
A detailed analysis of pediatric surgical malpractice claims in Germany: what is the probability of a pediatric surgeon to be accused or convicted? 61
33416989 2021
30
The Fellowship Effect: Does Surgical Subspecialty Training Affect Pediatric Surgery Case Volume? 61
33483280 2021
31
Structural and functional significance of scrotal ligament: a comparative histological study. 61
32894451 2021
32
Neonatal Escherichia coli infection in twins: clinical spectrum and management dilemma. 61
33504527 2021
33
Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes. 61
32813042 2021
34
Predictive factors for orchiectomy in adult's spermatic cord torsion: a case-control study. 61
33478388 2021
35
Testicular Workup for Ischemia and Suspected Torsion in Pediatric Patients and Resource Utilization. 61
32892138 2021
36
Proxeed plus salvage rat testis from ischemia- reperfused injury by enhancing antioxidant's activities and inhibition of iNOS expression. 61
33378987 2021
37
Point-of-Care Ultrasound detecting testicular rupture in pediatric emergency. 61
33392561 2020
38
Evaluation of parental sociocultural background and education level in response to pediatric testis torsion. 61
33077390 2020
39
Emergency scrotal exploration in children: Is it time for a change in mindset in the UK? 61
33317943 2020
40
Testicular AQP1 expression in a rat model of testicular Ischemia-Reperfusion injury. 61
33358303 2020
41
Timing and outcomes of testicular torsion during the COVID-19 crisis. 61
33223456 2020
42
Measuring complications of serious pediatric emergencies using ICD-10. 61
33374034 2020
43
Pediatric Trauma-Induced Testicular Torsion: A Surgical Emergency. 61
33378756 2020
44
ATPase inhibition by omeprazole reveals role of heat shock proteins on testicular torsion. 61
33368442 2020
45
Manual detorsion in testicular torsion: 5 years of experience at a single center. 61
32169343 2020
46
Nitroglycerin ameliorates sperm parameters, oxidative stress and testicular injury following by testicular torsion/detorsion in male rats. 61
33147433 2020
47
Delaying Urgent Exploration in Neonatal Testicular Torsion May Have Significant Consequences for the Contralateral Testis: A Critical Literature Review. 61
33373706 2020
48
Revisiting testicular torsion scores in an Asian healthcare system. 61
33077388 2020
49
The management of testicular torsion in the UK: How can we do better? A national quantitative and qualitative analysis of the factors affecting successful testicular salvage. 61
32933873 2020
50
Adjuvant pharmacological and surgical therapy for testicular torsion: Current state of the art. 61
32861587 2020
Sources

Variations for Testicular Torsion

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Expression for Testicular Torsion

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Search GEO for disease gene expression data for Testicular Torsion.
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Pathways for Testicular Torsion

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Pathways related to Testicular Torsion according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 36
Show member pathways
 12.77 TP53 TBPL1 NOS3 CASP3 BCL2
2
Apoptosis Pathway 70
Show member pathways
 12.13 TP53 NOS3 CASP3 BCL2
3
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.01 TP53 NOS3 CASP3 BCL2
4
DNA Damage Response 1
Show member pathways
 11.99 TP53 CASP3 BCL2 ADGRB1
5
Direct p53 effectors 1
11.86 TP53 PCNA BCL2
6
Activation of BH3-only proteins 65
Show member pathways
 11.83 TP53 CASP3 BCL2
7
p53 Signaling 63
Show member pathways
 11.83 TP53 CASP3 BCL2 ADGRB1
8
Sphingolipid signaling pathway 36
11.8 TP53 NOS3 BCL2
9
HIF-1 signaling pathway 36
11.72 PGK2 NOS3 BCL2
10
Senescence and Autophagy in Cancer 1
11.7 TP53 PCNA BCL2
11
AGE-RAGE signaling pathway in diabetic complications 36
11.65 NOS3 CASP3 BCL2
12
Corticotropin-releasing hormone signaling pathway 1
11.6 NOS3 CASP3 BCL2
13
Small cell lung cancer 36
11.57 TP53 CASP3 BCL2
14
Platinum drug resistance 36
11.41 TP53 CASP3 BCL2
15
Integrated Cancer Pathway 1
10.99 TP53 CASP3 BCL2
16
Amyotrophic lateral sclerosis (ALS) 1
10.71 TP53 CASP3 BCL2
17
Pathogenesis of ALS 63
10.2 TP53 CASP3 BCL2
Sources

GO Terms for Testicular Torsion

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Biological processes related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 TP53 RXFP2 NOS3 BCL2 ADGRB1
2 response to oxidative stress GO:0006979 9.54 TP53 PCNA BCL2
3 response to X-ray GO:0010165 9.4 TP53 CASP3
4 hematopoietic stem cell differentiation GO:0060218 9.32 TP53 ACE
5 T cell lineage commitment GO:0002360 9.16 TP53 BCL2
6 B cell lineage commitment GO:0002326 8.96 TP53 BCL2
7 neuron apoptotic process GO:0051402 8.8 TP53 CASP3 BCL2

Molecular functions related to Testicular Torsion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.92 TP53 INSL3 CASP3 BCL2
Sources

Sources for Testicular Torsion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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