MCID: TST040
MIFTS: 19

Testicular Trophoblastic Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testicular Trophoblastic Tumor

MalaCards integrated aliases for Testicular Trophoblastic Tumor:

Name: Testicular Trophoblastic Tumor 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4084
NCIt 50 C39934
UMLS 73 C1515301

Summaries for Testicular Trophoblastic Tumor

MalaCards based summary : Testicular Trophoblastic Tumor is related to choriocarcinoma and choriocarcinoma of ovary. An important gene associated with Testicular Trophoblastic Tumor is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and JAK-STAT signaling pathway (KEGG). Affiliated tissues include ovary, testis and placenta.

Related Diseases for Testicular Trophoblastic Tumor

Diseases related to Testicular Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 9.9 CSH1 CSH2
2 choriocarcinoma of ovary 9.9 CSH1 CSH2
3 non-gestational choriocarcinoma 9.9 CSH1 CSH2
4 choriocarcinoma of the testis 9.9 CSH1 CSH2
5 gestational trophoblastic neoplasm 9.9 CSH1 CSH2
6 chronic salpingitis 9.8 CSH1 CSH2
7 rh isoimmunization 9.8 CSH1 CSH2
8 germ cell and embryonal cancer 9.8 CSH1 CSH2
9 placenta disease 9.8 CSH1 CSH2
10 uterine anomalies 9.8 CSH1 CSH2
11 female reproductive system disease 9.7 CSH1 CSH2

Graphical network of the top 20 diseases related to Testicular Trophoblastic Tumor:



Diseases related to Testicular Trophoblastic Tumor

Symptoms & Phenotypes for Testicular Trophoblastic Tumor

Drugs & Therapeutics for Testicular Trophoblastic Tumor

Search Clinical Trials , NIH Clinical Center for Testicular Trophoblastic Tumor

Genetic Tests for Testicular Trophoblastic Tumor

Anatomical Context for Testicular Trophoblastic Tumor

MalaCards organs/tissues related to Testicular Trophoblastic Tumor:

41
Ovary, Testis, Placenta

Publications for Testicular Trophoblastic Tumor

Variations for Testicular Trophoblastic Tumor

Expression for Testicular Trophoblastic Tumor

Search GEO for disease gene expression data for Testicular Trophoblastic Tumor.

Pathways for Testicular Trophoblastic Tumor

Pathways related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 CSH1 CSH2
2
Show member pathways
11.32 CSH1 CSH2
3
Show member pathways
11.08 CSH1 CSH2

GO Terms for Testicular Trophoblastic Tumor

Cellular components related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 8.62 CSH1 CSH2

Biological processes related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.43 CSH1 CSH2
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.4 CSH1 CSH2
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 CSH1 CSH2
4 response to nutrient levels GO:0031667 9.32 CSH1 CSH2
5 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH1 CSH2
6 animal organ development GO:0048513 9.16 CSH1 CSH2
7 growth hormone receptor signaling pathway GO:0060396 8.96 CSH1 CSH2
8 positive regulation of growth GO:0045927 8.62 CSH1 CSH2

Molecular functions related to Testicular Trophoblastic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 CSH1 CSH2
2 hormone activity GO:0005179 8.96 CSH1 CSH2
3 growth hormone receptor binding GO:0005131 8.62 CSH1 CSH2

Sources for Testicular Trophoblastic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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