MCID: TST018
MIFTS: 45

Testicular Yolk Sac Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Yolk Sac Tumor

MalaCards integrated aliases for Testicular Yolk Sac Tumor:

Name: Testicular Yolk Sac Tumor 12 54 56 15 17 74
Testicular Yolk Sac Neoplasm 12
Endodermal-Sinus Tumor 54
Orchidoblastoma 54
Yolk Sac Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5344
NCIt 51 C8000

Summaries for Testicular Yolk Sac Tumor

MalaCards based summary : Testicular Yolk Sac Tumor, also known as testicular yolk sac neoplasm, is related to ovarian endodermal sinus tumor and endodermal sinus tumor. An important gene associated with Testicular Yolk Sac Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Wnt / Hedgehog / Notch. The drugs Paclitaxel and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Testicular Yolk Sac Tumor

Diseases related to Testicular Yolk Sac Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 ovarian endodermal sinus tumor 34.1 AFP GPC3 SALL4 SERPINA1
2 endodermal sinus tumor 33.9 AFP ALB GPC3 SALL4 SERPINA1
3 mature teratoma 30.3 AFP POU5F1
4 teratoma 30.3 AFP CDX2 POU5F1
5 mucinous cystadenofibroma 30.3 AFP CEACAM5 SERPINA1
6 gastric adenocarcinoma 30.2 AFP CDX2 CEACAM5 RUNX3
7 childhood endodermal sinus tumor 12.7
8 adult endodermal sinus tumor 12.7
9 childhood ovarian endodermal sinus tumor 12.7
10 mediastinal endodermal sinus tumors 12.5
11 macrocystic pattern testicular yolk sac tumor 12.5
12 solid pattern testicular yolk sac tumor 12.5
13 glandular-alveolar pattern testicular yolk sac tumor 12.5
14 myxomatous pattern testicular yolk sac tumor 12.5
15 papillary pattern testicular yolk sac tumor 12.5
16 enteric pattern testicular yolk sac tumor 12.5
17 reticular pattern testicular yolk sac tumor 12.5
18 endodermal sinus pattern testicular yolk sac tumor 12.5
19 polyvesicular vitelline pattern testicular yolk sac tumor 12.5
20 hepatoid pattern testicular yolk sac tumor 12.5
21 central nervous system endodermal sinus tumor 12.5
22 yolk sac tumor of central nervous system 12.0
23 testicular germ cell tumor 11.6
24 glandular pattern ovarian yolk sac tumor 11.4
25 hepatoid pattern ovarian yolk sac tumor 11.4
26 polyvesicular vitelline pattern ovarian yolk sac tumor 11.4
27 pineoblastoma 10.6
28 pineal gland cancer 10.6
29 pineocytoma 10.6
30 germ cells tumors 10.4
31 keratomalacia 10.4 TF TTR
32 median rhomboid glossitis 10.4 TF TTR
33 adenocarcinoma 10.4
34 embryonal carcinoma 10.4
35 blackwater fever 10.4 HP HPX
36 melancholia 10.4 HP TF
37 geniculate herpes zoster 10.4 HP SERPINA1
38 chronic inflammatory demyelinating polyneuropathy 10.4 HP TF TTR
39 polyembryoma 10.4 AFP SERPINA1
40 scrotal carcinoma 10.4 AFP SERPINA3
41 ovarian germ cell cancer 10.3 AFP SALL4
42 acinar cell cystadenocarcinoma 10.3 SERPINA1 SERPINA3
43 atransferrinemia 10.3 HP HPX TF
44 hepatic adenomas, familial 10.3 AFP GPC3
45 liver lymphoma 10.3 AFP CEACAM5
46 brain germinoma 10.3 AFP POU5F1
47 testicular malignant germ cell cancer 10.3 AFP FDPS GPC3
48 sella turcica neoplasm 10.3 F8 TTR
49 retinitis pigmentosa 7 10.3 SERPINA1 TF TTR
50 melanotic medulloblastoma 10.3 AFP CEACAM5

Graphical network of the top 20 diseases related to Testicular Yolk Sac Tumor:



Diseases related to Testicular Yolk Sac Tumor

Symptoms & Phenotypes for Testicular Yolk Sac Tumor

MGI Mouse Phenotypes related to Testicular Yolk Sac Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 AFP AHSG ALB CDX2 F8 GPC3
2 digestive/alimentary MP:0005381 9.92 ALB CDX2 GPC3 MDM2 POU5F1 RUNX3
3 mortality/aging MP:0010768 9.73 AFP ALB CDX2 F8 GPC3 HP
4 limbs/digits/tail MP:0005371 9.63 AHSG CDX2 GPC3 MDM2 RUNX3 SALL4
5 renal/urinary system MP:0005367 9.17 ALB GPC3 HP HPX MDM2 SALL4

Drugs & Therapeutics for Testicular Yolk Sac Tumor

Drugs for Testicular Yolk Sac Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
3
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
4
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 441203 84093 2767
5
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
6
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
7
Oxaliplatin Approved, Investigational Phase 3,Phase 1 61825-94-3 6857599 5310940 9887054 43805
8
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 1177-87-3
11
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
12
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
13
Captopril Approved Phase 3 62571-86-2 44093
14
Palivizumab Approved, Investigational Phase 3 188039-54-5
15
Ribavirin Approved Phase 3 36791-04-5 37542
16
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
17
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
18
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
19
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
20
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718 468682
21
Carboplatin Approved Phase 3,Phase 2 41575-94-4 38904 10339178 498142
22
Promethazine Approved, Investigational Phase 3 60-87-7 4927
23
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
24
Vinblastine Approved Phase 3 865-21-4 13342 241903
25 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
26 Etoposide phosphate Phase 2, Phase 3,Phase 3
27 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
28 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
29 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
30 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
31 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
32 Alkylating Agents Phase 3,Phase 1,Phase 2
33 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
34
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
35 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
36 Immunologic Factors Phase 3,Phase 1,Phase 2
37 Antimetabolites Phase 3,Phase 1,Phase 2
38 Anti-Infective Agents Phase 3,Phase 1,Phase 2
39 Antiviral Agents Phase 3,Phase 1,Phase 2
40 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
41 BB 1101 Phase 3,Phase 1,Phase 2
42 HIV Protease Inhibitors Phase 3,Phase 1
43
protease inhibitors Phase 3,Phase 1
44 Angiotensin-Converting Enzyme Inhibitors Phase 3
45 Antihypertensive Agents Phase 3
46 Antirheumatic Agents Phase 3
47 Antibodies Phase 3,Phase 1
48 Antibodies, Monoclonal Phase 3,Phase 1
49 Immunoglobulins Phase 3,Phase 1
50
Hydroxyitraconazole Phase 3

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
4 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
5 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
7 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
8 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
9 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
10 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
12 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
13 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
14 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
15 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
16 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
19 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
20 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
21 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
22 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
23 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
24 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
25 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
26 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
27 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
28 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
29 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
30 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
31 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
32 Biological Therapy in Treating Patients With Metastatic Cancer Completed NCT00004604 Phase 1
33 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
34 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
35 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
36 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
37 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
38 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
39 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
40 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
41 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
42 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
43 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
44 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
45 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755

Search NIH Clinical Center for Testicular Yolk Sac Tumor

Genetic Tests for Testicular Yolk Sac Tumor

Anatomical Context for Testicular Yolk Sac Tumor

MalaCards organs/tissues related to Testicular Yolk Sac Tumor:

42
Bone, Bone Marrow, Brain, Spinal Cord, Colon, T Cells, Small Intestine

Publications for Testicular Yolk Sac Tumor

Articles related to Testicular Yolk Sac Tumor:

(show all 16)
# Title Authors Year
1
Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant. ( 29608939 )
2018
2
Testicular yolk sac tumor and impaired spermatogenesis in a Holstein Friesian calf. ( 26214222 )
2015
3
Advanced childhood testicular yolk sac tumor with bone metastasis: a case report. ( 25733287 )
2015
4
Ruptured testicular yolk sac tumor. ( 25148504 )
2014
5
Experience with the treatment of testicular yolk sac tumor in children: a report of 14 cases. ( 25555873 )
2014
6
Testicular yolk sac tumor of myxomatous, reticular, and polyvesicular vitelline type in a newborn calf. ( 24153035 )
2013
7
Testicular yolk sac tumor. ( 23945483 )
2013
8
Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor. ( 22410253 )
2012
9
Metastasis of testicular yolk sac tumor to cauda equina. ( 21355679 )
2011
10
Sonographic appearance of a testicular yolk sac tumor in a 2-year-old boy. ( 16960883 )
2007
11
Involvement of adenomatous polyposis coli (APC) gene in testicular yolk sac tumor of infants. ( 16360415 )
2006
12
Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants. ( 12875960 )
2003
13
Metastatic spinal cord compression of testicular yolk sac tumor. ( 11981629 )
2002
14
Treatment of a stage I testicular yolk sac tumor with vascular invasion. ( 7572162 )
1995
15
Production of 13 plasma proteins by human testicular yolk sac tumor transplanted into nude mice. ( 1906196 )
1991
16
Epidural metastasis of testicular yolk sac tumor: an unusual cause of spinal cord compression. Case report. ( 1819328 )
1991

Variations for Testicular Yolk Sac Tumor

Expression for Testicular Yolk Sac Tumor

Search GEO for disease gene expression data for Testicular Yolk Sac Tumor.

Pathways for Testicular Yolk Sac Tumor

GO Terms for Testicular Yolk Sac Tumor

Cellular components related to Testicular Yolk Sac Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.88 ALB CDX2 MDM2 SALL4 TTR
2 collagen-containing extracellular matrix GO:0062023 9.8 AHSG GPC3 HPX SERPINA1 SERPINA3
3 endoplasmic reticulum lumen GO:0005788 9.8 AFP AHSG ALB F8 GPC3 SERPINA1
4 extracellular region GO:0005576 9.73 AFP AHSG ALB CEACAM5 F8 HP
5 platelet alpha granule lumen GO:0031093 9.72 AHSG ALB F8 SERPINA1 SERPINA3
6 secretory granule lumen GO:0034774 9.63 AHSG SERPINA3 TF
7 blood microparticle GO:0072562 9.63 AHSG ALB HP HPX SERPINA3 TF
8 endocytic vesicle lumen GO:0071682 9.43 HP HPX
9 extracellular space GO:0005615 9.36 AFP AHSG ALB F8 HP HPX
10 extracellular exosome GO:0070062 10.07 AHSG ALB CEACAM5 HP HPX NAPSA

Biological processes related to Testicular Yolk Sac Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.77 AHSG HP SERPINA1 SERPINA3 TTR
2 post-translational protein modification GO:0043687 9.73 AFP AHSG ALB GPC3 SERPINA1 TF
3 platelet degranulation GO:0002576 9.63 AHSG ALB F8 SERPINA1 SERPINA3 TF
4 negative regulation of peptidase activity GO:0010466 9.58 GPC3 SERPINA1 SERPINA3
5 somatic stem cell population maintenance GO:0035019 9.5 CDX2 POU5F1 SALL4
6 blastocyst development GO:0001824 9.43 CDX2 POU5F1
7 acute-phase response GO:0006953 9.35 AHSG F8 HP SERPINA1 SERPINA3
8 cellular protein metabolic process GO:0044267 9.23 AFP AHSG ALB GPC3 NAPSA SERPINA1

Molecular functions related to Testicular Yolk Sac Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.8 GPC3 SERPINA1 SERPINA3

Sources for Testicular Yolk Sac Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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