MCID: TST018
MIFTS: 39

Testicular Yolk Sac Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Testicular Yolk Sac Tumor

MalaCards integrated aliases for Testicular Yolk Sac Tumor:

Name: Testicular Yolk Sac Tumor 12 20 54 15 17 70
Testicular Yolk Sac Neoplasm 12
Endodermal-Sinus Tumor 20
Orchidoblastoma 20
Yolk Sac Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5344
NCIt 50 C8000
UMLS 70 C0014145 C0279708

Summaries for Testicular Yolk Sac Tumor

MalaCards based summary : Testicular Yolk Sac Tumor, also known as testicular yolk sac neoplasm, is related to cystadenoma and liver disease. An important gene associated with Testicular Yolk Sac Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and pineal, and related phenotype is homeostasis/metabolism.

Related Diseases for Testicular Yolk Sac Tumor

Diseases related to Testicular Yolk Sac Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 cystadenoma 29.5 SERPINA3 AFP
2 liver disease 28.7 TF SERPINA3 AFP
3 childhood endodermal sinus tumor 11.6
4 ovarian endodermal sinus tumor 11.6
5 adult endodermal sinus tumor 11.5
6 childhood ovarian endodermal sinus tumor 11.5
7 macrocystic pattern testicular yolk sac tumor 11.5
8 solid pattern testicular yolk sac tumor 11.5
9 glandular-alveolar pattern testicular yolk sac tumor 11.5
10 myxomatous pattern testicular yolk sac tumor 11.5
11 papillary pattern testicular yolk sac tumor 11.5
12 enteric pattern testicular yolk sac tumor 11.5
13 reticular pattern testicular yolk sac tumor 11.5
14 yolk sac tumor of central nervous system 11.5
15 testicular germ cell tumor 11.4
16 central nervous system endodermal sinus tumor 11.4
17 endodermal sinus pattern testicular yolk sac tumor 11.4
18 polyvesicular vitelline pattern testicular yolk sac tumor 11.4
19 hepatoid pattern testicular yolk sac tumor 11.4
20 glandular pattern ovarian yolk sac tumor 11.2
21 hepatoid pattern ovarian yolk sac tumor 11.2
22 polyvesicular vitelline pattern ovarian yolk sac tumor 11.2
23 endodermal sinus tumor 10.8
24 germ cells tumors 10.8
25 germ cell cancer 10.5
26 pineoblastoma 10.5
27 pineal gland cancer 10.5
28 pineocytoma 10.5
29 rare tumor 10.4
30 rhabdomyosarcoma 10.4
31 clear cell adenocarcinoma 10.4
32 sacrococcygeal teratoma 10.4
33 cystic teratoma 10.3
34 botryoid rhabdomyosarcoma 10.3
35 dysgerminoma 10.3
36 ovarian embryonal carcinoma 10.3
37 gastric adenocarcinoma 10.3
38 mediastinal endodermal sinus tumors 10.3
39 mixed germ cell tumor 10.3
40 blackwater fever 10.2 HPX HP
41 ataxia and polyneuropathy, adult-onset 10.2
42 hydrocephalus 10.2
43 transitional cell carcinoma 10.2
44 endometrial adenocarcinoma 10.2
45 adenocarcinoma 10.2
46 ovarian mixed germ cell neoplasm 10.2
47 exophthalmos 10.2
48 overgrowth syndrome 10.2
49 pediatric multiple sclerosis 10.2 TTR HPX
50 ocular motor apraxia 10.1

Graphical network of the top 20 diseases related to Testicular Yolk Sac Tumor:



Diseases related to Testicular Yolk Sac Tumor

Symptoms & Phenotypes for Testicular Yolk Sac Tumor

MGI Mouse Phenotypes related to Testicular Yolk Sac Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 AFP AHSG HP HPX RUNX3 SERPINA3

Drugs & Therapeutics for Testicular Yolk Sac Tumor

Drugs for Testicular Yolk Sac Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Captopril Approved Phase 3 62571-86-2 44093
4
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
10
Promethazine Approved, Investigational Phase 3 60-87-7 4927
11
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
12
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
13
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
14
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
15
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
16
Ifosfamide Approved Phase 3 3778-73-2 3690
17
Vinblastine Approved Phase 3 865-21-4 241903 13342
18 Antibodies Phase 3
19 Immunoglobulins Phase 3
20 Anti-Infective Agents Phase 3
21 Antiviral Agents Phase 3
22 Antibodies, Monoclonal Phase 3
23
protease inhibitors Phase 3
24 Angiotensin-Converting Enzyme Inhibitors Phase 3
25 Antihypertensive Agents Phase 3
26 HIV Protease Inhibitors Phase 3
27 Cytochrome P-450 CYP3A Inhibitors Phase 3
28
Hydroxyitraconazole Phase 3 108222
29 Cytochrome P-450 Enzyme Inhibitors Phase 3
30 Antifungal Agents Phase 3
31 Amebicides Phase 3
32 Antiparasitic Agents Phase 3
33 Liposomal amphotericin B Phase 3
34 Antiprotozoal Agents Phase 3
35 Liver Extracts Phase 3
36 Histamine H2 Antagonists Phase 3
37 Antibiotics, Antitubercular Phase 3
38 Anti-Bacterial Agents Phase 3
39 Tubulin Modulators Phase 3
40 Alkylating Agents Phase 3
41 Albumin-Bound Paclitaxel Phase 3
42 Antimitotic Agents Phase 3
43
Isophosphamide mustard Phase 3 100427
44
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
45
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
46
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
47
Oprelvekin Approved, Investigational Phase 2 145941-26-0
48
Etoposide Approved Phase 2 33419-42-0 36462
49
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
50
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
3 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
4 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
7 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
8 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
9 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
10 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
11 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
12 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
13 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
14 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
15 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
16 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
17 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
18 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
19 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
20 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
21 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
22 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
23 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
24 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
25 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
26 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Active, not recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Not yet recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
29 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
30 A Phase I Study of Active Immunotherapy With Carcinoembryonic Antigen RNA-Pulsed, Autologous Human Cultured Dendritic Cells in Patients With Metastatic Malignancies Expressing Carcinoembryonic Antigen Completed NCT00004604 Phase 1
31 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
32 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
33 A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
34 A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
35 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
36 A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors Completed NCT00929903 Phase 1 pazopanib hydrochloride
37 Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressing Autologous T Cells as an Immunotherapy for Children With Solid Tumors (CARE) Not yet recruiting NCT04715191 Phase 1 Cytoxan;Fludara
38 Interleukin-15 Armored Glypican-3-specific Chimeric Antigen Receptor Expressing Autologous T Cells as Immunotherapy for Children With Solid Tumors Not yet recruiting NCT04377932 Phase 1 Cytoxan;Fludara
39 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
40 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465
41 A Study Of 18 FDG PET In The Prediction Of Relapse In Patients With A Clinical Stage I Non-Seminomatous Germ Cell Tumor Completed NCT00045045
42 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
43 Correlation of Histopathology, Immunohistochemistry and Quantitative Radiology With Outcome in Early Stage Nonseminomatous Germ Cell Tumor Completed NCT00003800
44 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
45 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521
46 Anti-1-amino-3-18F-flurocyclobutane-1-carboxylic Acid (Axumin) Positron Emission Tomography/Computed Tomography Prior to Retroperitoneal Lymph Node Dissection for Testicular Cancer Completed NCT03426865 Axumin PET scan
47 Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. Recruiting NCT04283773

Search NIH Clinical Center for Testicular Yolk Sac Tumor

Genetic Tests for Testicular Yolk Sac Tumor

Anatomical Context for Testicular Yolk Sac Tumor

MalaCards organs/tissues related to Testicular Yolk Sac Tumor:

40
Testis, Ovary, Pineal, Bone Marrow, Bone, Lymph Node, Spinal Cord

Publications for Testicular Yolk Sac Tumor

Articles related to Testicular Yolk Sac Tumor:

(show top 50) (show all 1377)
# Title Authors PMID Year
1
[Clinical analysis of stage I pediatric testicular yolk sac tumors: a report of ten cases]. 54 61
19000459 2008
2
Alpha-fetoprotein (AFP)-producing gastric carcinoma. Is it hepatoid differentiation? 54 61
1690592 1990
3
Vasculogenic Mesenchymal Tumor: A Clinicopathologic and Molecular Study of 55 Cases of a Distinctive Neoplasm Originating From Mediastinal Yolk Sac Tumor and an Occasional Precursor to Angiosarcoma. 61
33136584 2021
4
Primary intracranial pure endodermal sinus tumor: a retrospective series of 6 cases in a single center and a systematic review of overall survival. 61
33753128 2021
5
Yolk Sac Tumor Arising in Uterine Carcinosarcoma With Endometrioid and Serous Components: A Case Report With Immunohistochemical Analysis. 61
33770060 2021
6
Unusual Presentation, Relapse, and Metastasis of a Pediatric Testicular Yolk Sac Tumor: Case Report. 61
33141029 2021
7
Surveillance Only for High-risk FIGO Stage IA/IB Malignant Ovarian Germ Cell Tumors: Results From a National Cancer Database. 61
33710136 2021
8
Two concurrent cancers in a 19-year-old patient: yolk sac ovarian tumor and metastatic gastrointestinal tract malignancy - case report. 61
33689915 2021
9
Malignant sacrococcygeal germ cell tumors in childhood: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. 61
33219741 2021
10
Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report. 61
33541424 2021
11
Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors. 61
33668443 2021
12
Testicular germ cell tumors type 2 have high RNA expression of LDHB, the gene for lactate dehydrogenase subunit B. 61
33565425 2021
13
Primary yolk sac tumor of pterygopalatine fossa with loss of vision: A case report. 61
33663127 2021
14
Vaginal Yolk Sac Tumor: A Case Series and Review of the Literature. 61
32628992 2021
15
Molecular Characterization of Ovarian Yolk Sac Tumor (OYST). 61
33435376 2021
16
Multimodal Treatment of Children With Sacrococcygeal Yolk Sac Tumor: Retrospective Analysis of Clinicopathology Characteristics and Relapse-free Survival. 61
33512871 2021
17
18F-FDG PET/CT in pure testicular Yolk Sac Tumor in adult. 61
33047930 2021
18
Hepatoid Teratoma, Hepatoid Yolk Sac Tumor, and Hepatocellular Carcinoma: A Morphologic and Immunohistochemical Study of 30 Cases. 61
32991342 2021
19
Clinicopathological Features, Prognostic Factors, Survival Trends, and Treatment of Malignant Ovarian Germ Cell Tumors: A SEER Database Analysis. 61
33706324 2021
20
Detection of Circulating Tumor Cells (CTCs) in Patients with Testicular Germ Cell Tumors. 61
32852768 2021
21
Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9. 61
32852759 2021
22
Malignant Mixed Germ Cell Tumors of the Ovary: An Analysis of 100 Cases Emphasizing the Frequency and Interrelationships of Their Tumor Types. 61
33284192 2020
23
Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report. 61
32498578 2020
24
A Rare Case of Immature Sacrococcygeal Teratoma With Lymph Node Metastasis in a Neonate. 61
33323883 2020
25
Imaging Appearance of Nongerminoma Pediatric Ovarian Germ Cell Tumors Does Not Discriminate Benign from Malignant Histology. 61
33316416 2020
26
[Yolk sac tumor of spinal cord:report of a case]. 61
33287527 2020
27
Yolk sac tumor of the fourth ventricle in a 3-year-old boy: imaging features. 61
32253490 2020
28
HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors. 61
32561848 2020
29
A Case of Primary Sinonasal Yolk Sac Tumor. 61
32910044 2020
30
Clinical and Computed Tomographic Features of Ovarian Lesions in Infants, Children, and Adolescents: A Series of 222 Cases. 61
33144230 2020
31
Successful treatment of non-midline primary malignant germ cell tumors with yolk sac components in neonates: report of 2 cases. 61
33126205 2020
32
Juvenile Granulosa Cell Tumors of the Ovary. 61
32561911 2020
33
Ovarian cryopreservation for children aged 3 years or younger: A report of three cases. 61
32779331 2020
34
Teratoid Hepatoblastoma With Yolk Sac-Like and Neuroendocrine Elements. 61
32425118 2020
35
Fine needle aspiration of mediastinal germ cell tumors. 61
32444243 2020
36
Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases. 61
31846368 2020
37
Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors. 61
32205480 2020
38
Primary yolk sac tumor of orbit: Report of a rare case. 61
32594074 2020
39
[Acute Megakaryoblastic Leukemia Developed after the Surgical Treatment of Mediastinal Malignant Germ Cell Tumor]. 61
32641675 2020
40
Clinical characteristics and prognostic factors of male yolk sac tumor: a Surveillance, Epidemiology, and End Results program study. 61
32562046 2020
41
Primary Pancreatic Yolk Sac Tumor Presenting as Diffusely Enlarged Pancreas in Initial 18F-FDG PET/CT. 61
32332317 2020
42
Yolk sac tumor differentiation in urothelial carcinoma of the urinary bladder: a case report and differential diagnosis. 61
32493368 2020
43
Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components. 61
31911616 2020
44
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features. 61
31468350 2020
45
A clinical review of ovarian tumors in children and adolescents. 61
32346848 2020
46
[A Case of Metachronous Testicular Tumor Developing Twenty Years after Treatment of Retroperitoneal Extragonadal Germ Cell Tumor]. 61
32605355 2020
47
Maternal exposure to environmental endocrine disruptors during pregnancy is associated with pediatric germ cell tumors. 61
32581411 2020
48
Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin. 61
31033797 2020
49
A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy. 61
31917123 2020
50
Trends in the surgical management of malignant ovarian germcell tumors. 61
32008791 2020

Variations for Testicular Yolk Sac Tumor

Expression for Testicular Yolk Sac Tumor

Search GEO for disease gene expression data for Testicular Yolk Sac Tumor.

Pathways for Testicular Yolk Sac Tumor

Pathways related to Testicular Yolk Sac Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 TTR AFP

GO Terms for Testicular Yolk Sac Tumor

Cellular components related to Testicular Yolk Sac Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 TTR TF SERPINA3 HPX HP AHSG
2 extracellular region GO:0005576 9.7 TTR TF SERPINA3 HPX HP AHSG
3 collagen-containing extracellular matrix GO:0062023 9.63 SERPINA3 HPX AHSG
4 endoplasmic reticulum lumen GO:0005788 9.58 TF AHSG AFP
5 extracellular space GO:0005615 9.5 TTR TF SERPINA3 HPX HP AHSG
6 platelet alpha granule lumen GO:0031093 9.43 SERPINA3 AHSG
7 secretory granule lumen GO:0034774 9.43 TF SERPINA3 AHSG
8 endocytic vesicle lumen GO:0071682 9.32 HPX HP
9 blood microparticle GO:0072562 9.02 TF SERPINA3 HPX HP AHSG

Biological processes related to Testicular Yolk Sac Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.56 TTR SERPINA3 HP AHSG
2 post-translational protein modification GO:0043687 9.5 TF AHSG AFP
3 SMAD protein signal transduction GO:0060395 9.4 TF AFP
4 cellular iron ion homeostasis GO:0006879 9.37 TF HPX
5 platelet degranulation GO:0002576 9.33 TF SERPINA3 AHSG
6 cellular protein metabolic process GO:0044267 9.26 TTR TF AHSG AFP
7 acute-phase response GO:0006953 8.8 SERPINA3 HP AHSG

Sources for Testicular Yolk Sac Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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