MCID: TST020
MIFTS: 28

Testis Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testis Seminoma

MalaCards integrated aliases for Testis Seminoma:

Name: Testis Seminoma 12 15
Testicular Seminoma Pure 12
Seminoma of Testis 12
Seminoma Testis 12
Seminoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5842
MeSH 44 D018239
NCIt 50 C9309
SNOMED-CT 67 443675005
UMLS 70 C0036631

Summaries for Testis Seminoma

MalaCards based summary : Testis Seminoma, also known as testicular seminoma pure, is related to testicular germ cell tumor and seminoma. An important gene associated with Testis Seminoma is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are Post-translational modification- synthesis of GPI-anchored proteins and Folate biosynthesis. The drugs Granisetron and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and bone marrow.

Related Diseases for Testis Seminoma

Diseases related to Testis Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 11.2
2 seminoma 10.3
3 testicular cancer 10.2
4 teratoma 10.1
5 spermatocytoma 10.1
6 testicular spermatocytic seminoma 10.1
7 renal cell carcinoma, nonpapillary 10.1
8 germ cell cancer 10.1
9 mature teratoma 10.1
10 germ cells tumors 10.1
11 orchitis 10.0
12 ureteral obstruction 10.0
13 extragonadal seminoma 10.0
14 paraplegia 10.0
15 spinal cord injury 10.0
16 granular cell carcinoma 9.9 PBOV1 HHLA1
17 sarcoidosis 1 9.9
18 enterocolitis 9.9
19 kidney cancer 9.9
20 gliosarcoma 9.9
21 malignant teratoma 9.9
22 lymphopenia 9.9
23 intermediate malignant teratoma 9.9
24 hydrocele 9.9
25 hypereosinophilic syndrome 9.9
26 nonseminomatous germ cell tumor 9.9
27 testicular seminoma 9.9
28 papillary transitional carcinoma 9.9 PBOV1 HHLA1
29 dentin caries 9.6 ALPI ALPG
30 hypophosphatasia 9.5 ALPI ALPG

Graphical network of the top 20 diseases related to Testis Seminoma:



Diseases related to Testis Seminoma

Symptoms & Phenotypes for Testis Seminoma

Drugs & Therapeutics for Testis Seminoma

Drugs for Testis Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
3
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
7
Mesna Approved, Investigational Phase 3 3375-50-6 598
8
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
10
Lenograstim Approved, Investigational Phase 3 135968-09-1
11
Promethazine Approved, Investigational Phase 3 60-87-7 4927
12
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
13 Antiemetics Phase 3
14 Gastrointestinal Agents Phase 3
15 Neurotransmitter Agents Phase 3
16 Immunologic Factors Phase 3
17 Etoposide phosphate Phase 3
18 Antimitotic Agents Phase 3
19 Adjuvants, Immunologic Phase 3
20 Albumin-Bound Paclitaxel Phase 3
21 Tubulin Modulators Phase 3
22 Histamine H2 Antagonists Phase 3
23 Antibiotics, Antitubercular Phase 3
24 Anti-Bacterial Agents Phase 3
25 Dermatologic Agents Phase 3
26 Podophyllotoxin Phase 3 518-28-5
27 Keratolytic Agents Phase 3
28
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
29
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
30
Fluorouracil Approved Phase 2 51-21-8 3385
31
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
32
leucovorin Approved Phase 2 58-05-9 6006
33
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
34
Ipilimumab Approved Phase 2 477202-00-9
35
nivolumab Approved Phase 2 946414-94-4
36
Durvalumab Approved, Investigational Phase 2 1428935-60-7
37
Ifosfamide Approved Phase 2 3778-73-2 3690
38
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
39
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
40
Lysine Approved, Nutraceutical Phase 2 56-87-1 5962
41
Alvocidib Experimental, Investigational Phase 2 146426-40-6, 131740-09-5 5287969
42
Tremelimumab Investigational Phase 2 745013-59-6
43 Micronutrients Phase 2
44 Antidotes Phase 2
45 Trace Elements Phase 2
46 Nutrients Phase 2
47 Vitamin B Complex Phase 2
48 Folate Phase 2
49 Hormones Phase 2
50 Immunosuppressive Agents Phase 2

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
2 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
4 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
5 A Randomized Phase III Study Comparing One Course of Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) and One Course of Carboplatin AUC7 in Clinical Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
6 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
7 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
8 A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
9 A Multi-Centre Phase II Study Using Carboplatin AUC-10 for Metastatic Seminoma With IGCCCG Good Prognosis Disease-Therapy Directed by Initial Metabolic Response on PET-CT Completed NCT02272816 Phase 2 Carboplatin AUC-10
10 A Prospective,Multicenter, Phase II Study to Evaluate the Contribution of the Imaging TEP to the Expression of intégrines αvβ3 for the Characterization of the Residual Masses of Non-seminoma Tumors at the End of Chemotherapy Completed NCT02317393 Phase 2
11 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
12 Therapeutic Strategy Guided by PET-TDM for Patients With Grade I or Metastatic Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
13 Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma. A Multicenter, Open Label Phase II Trial With Two Cohorts Recruiting NCT03937843 Phase 2 Carboplatin;Cisplatin;Etoposide
14 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
15 A Single-arm, Phase II Study of Durvalumab (MEDI4736) and Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
16 Carboplatin Chemotherapy and Involved Node Radiotherapy in Stage IIA/B Seminoma Active, not recruiting NCT01593241 Phase 2 Carboplatin
17 Multicenter Phase 2 Trial of ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Terminated NCT01055067 Phase 2 Tivantinib (ARQ 197)
18 A Phase II Study Of Imatinib Mesylate (Gleevec, Formerly Known As STI571; IND 61,135, NSC #716051) In Patients With Refractory Seminoma Terminated NCT00042952 Phase 2 imatinib mesylate
19 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
20 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
21 Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours: Potential Risks and Consequences for the Conceptus Unknown status NCT03262207
22 A Phase II Study of Adjuvant Proton Radiation Therapy for the Treatment of Stage I, IIA and IIB Seminoma Completed NCT01557790
23 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
24 Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients Completed NCT00705094
25 A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors Recruiting NCT04435756
26 Surgery in Early Metastatic Seminoma (SEMS): Phase II Trial of Retroperitoneal Lymph Node Dissection as First-Line Treatment for Testicular Seminoma With Isolated Retroperitoneal Disease (1-3cm) Active, not recruiting NCT02537548

Search NIH Clinical Center for Testis Seminoma

Genetic Tests for Testis Seminoma

Anatomical Context for Testis Seminoma

MalaCards organs/tissues related to Testis Seminoma:

40
Testis, Lymph Node, Bone Marrow, Spinal Cord, Kidney

Publications for Testis Seminoma

Articles related to Testis Seminoma:

(show all 24)
# Title Authors PMID Year
1
Supraclavicular left neck mass: an unusual presentation of metastatic testicular cancer in two older men. 61
32327457 2020
2
Radiotherapy in testicular germ cell tumours - a literature review. 61
29180926 2017
3
Rare late metastasis of testis seminoma to the bladder. 61
26600894 2015
4
Expression and Localization of Lung Surfactant Proteins in Human Testis. 61
26599233 2015
5
The more you look, the more you find: challenging results on FDG-PET CT in a patient with neurofibromatosis type I. 61
24885974 2014
6
[Autoimmune encephalitis, clinical, radiological and immunological data]. 61
23099105 2013
7
[Stage I seminoma and radiotherapy: to bury it or not?]. 61
18760650 2008
8
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. 61
16523487 2006
9
[Case of NASH exacerbated after testectomy due to seminoma]. 61
15387271 2004
10
[Clinical presentation, treatment, and follow-up of 32 patients with a primary intracranial germinoma, registered during the previous 15 years in the Dutch Pathological-Anatomical National Automated Archive (PALGA)]. 61
11109472 2000
11
[Therapeutic strategy in stage I seminomas: which lymph node areas are to be irradiated?]. 61
10212959 1999
12
[CT findings of metastatic and primary neoplasms of the kidney: a comparative study]. 61
11776798 1999
13
Establishment and characterization of a new human testicular seminoma cell line, JKT-1. 61
9624562 1998
14
Respiratory syncytial virus, a rare cause of severe pneumonia following bone marrow transplantation. 61
7492628 1995
15
Treatment of stage I testis seminoma by radiotherapy: long-term results--a 30-year experience. 61
8365943 1993
16
[Histopathological study of intracranial germinoma]. 61
8403104 1993
17
Early detection of relapse after treatment for metastatic germ cell tumour of the testis: an exercise in medical audit. 61
7678749 1993
18
Positive hydrocele cytology accompanying testis seminoma. 61
1546428 1992
19
Glutathione transferase isoenzymes from human testis. 61
2688647 1989
20
A patient with testis seminoma, sarcoidosis, and neutropenic enterocolitis. 61
6714970 1984
21
Seminoma in childhood. 61
6108374 1980
22
[Clonal analysis of a transplantable rat seminoma]. 61
462547 1979
23
Primary malignant germinal tumors of the mediastinum. A study of 24 cases. 61
1237349 1975
24
Rupture of the testis: seminoma. 61
13364269 1956

Variations for Testis Seminoma

Expression for Testis Seminoma

Search GEO for disease gene expression data for Testis Seminoma.

Pathways for Testis Seminoma

Pathways related to Testis Seminoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.15 ALPI ALPG
2
Show member pathways
10.42 ALPI ALPG
3 9.83 ALPI ALPG

GO Terms for Testis Seminoma

Molecular functions related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alkaline phosphatase activity GO:0004035 8.62 ALPI ALPG

Sources for Testis Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....