MCID: TST020
MIFTS: 35

Testis Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testis Seminoma

MalaCards integrated aliases for Testis Seminoma:

Name: Testis Seminoma 12 15
Testicular Seminoma Pure 12
Seminoma of Testis 12
Seminoma Testis 12
Seminoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5842
MeSH 44 D018239
NCIt 50 C7328 C9309
SNOMED-CT 68 36741007
UMLS 73 C0036631

Summaries for Testis Seminoma

MalaCards based summary : Testis Seminoma, also known as testicular seminoma pure, is related to testicular spermatocytic seminoma and testicular germ cell tumor. An important gene associated with Testis Seminoma is DNMT3L (DNA Methyltransferase 3 Like), and among its related pathways/superpathways are Metabolism and PAK Pathway. Affiliated tissues include testis, brain and ovary, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cellular

Related Diseases for Testis Seminoma

Diseases related to Testis Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 testicular spermatocytic seminoma 30.1 DNMT3A DNMT3B DNMT3L H2AFZ
2 testicular germ cell tumor 11.6
3 testicular seminoma 11.3
4 seminoma 10.3
5 atrophy of prostate 10.2 SLC2A1 SLC2A2
6 testicular malignant germ cell cancer 10.2 ALPP DNMT3L SLC2A5
7 ovarian squamous cell carcinoma 10.2 SLC2A1 SMUG1
8 tick infestation 10.2 ALPL ALPP
9 cellular ependymoma 10.2 GFAP SMUG1
10 primitive neuroectodermal tumor of the cervix uteri 10.2 GFAP PTPRC
11 protoplasmic astrocytoma 10.2 GFAP SMUG1
12 hypophosphatasia, infantile 10.2 ALPL ALPP
13 cryptorchidism, unilateral or bilateral 10.2
14 hepatic tuberculosis 10.2 ALPP SMUG1
15 immunodeficiency-centromeric instability-facial anomalies syndrome 10.2 DNMT3A DNMT3B DNMT3L
16 mandibular cancer 10.2 GFAP SMUG1
17 brain sarcoma 10.1 PTPRC SMUG1
18 lymphosarcoma 10.1 DNMT3A PTPRC SMUG1
19 spermatocytoma 10.1
20 trigeminal nerve neoplasm 10.1 GFAP PTPRC
21 neurilemmoma of the fifth cranial nerve 10.0 GFAP PTPRC
22 oculomotor nerve paralysis 10.0 PNMA2 SMUG1
23 third cranial nerve disease 10.0 PNMA2 SMUG1
24 enterocolitis 9.9
25 primary amebic meningoencephalitis 9.9
26 germ cell cancer 9.9
27 testicular cancer 9.9
28 gliosarcoma 9.9
29 teratoma 9.9
30 mature teratoma 9.9
31 hydrocele 9.9
32 spinal cord injury 9.9
33 orchitis 9.9
34 paraplegia 9.9
35 acute vascular insufficiency of intestine 9.7 HPGDS TJP1

Graphical network of the top 20 diseases related to Testis Seminoma:



Diseases related to Testis Seminoma

Symptoms & Phenotypes for Testis Seminoma

GenomeRNAi Phenotypes related to Testis Seminoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.02 ALPI ALPL ALPP FHL2 PTPRC

MGI Mouse Phenotypes related to Testis Seminoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 AGFG1 ALPL DNMT3A DNMT3B DNMT3L GFAP
2 mortality/aging MP:0010768 9.4 ALPL DNMT3A DNMT3B DNMT3L GFAP H2AFZ

Drugs & Therapeutics for Testis Seminoma

Search Clinical Trials , NIH Clinical Center for Testis Seminoma

Genetic Tests for Testis Seminoma

Anatomical Context for Testis Seminoma

MalaCards organs/tissues related to Testis Seminoma:

41
Testis, Brain, Ovary, Spinal Cord, Prostate, Cervix

Publications for Testis Seminoma

Articles related to Testis Seminoma:

# Title Authors Year
1
Rare late metastasis of testis seminoma to the bladder. ( 26600894 )
2015
2
Treatment of stage I testis seminoma by radiotherapy: long-term results--a 30-year experience. ( 8365943 )
1993
3
Positive hydrocele cytology accompanying testis seminoma. ( 1546428 )
1992
4
A patient with testis seminoma, sarcoidosis, and neutropenic enterocolitis. ( 6714970 )
1984
5
Rupture of the testis: seminoma. ( 13364269 )
1956

Variations for Testis Seminoma

Expression for Testis Seminoma

Search GEO for disease gene expression data for Testis Seminoma.

Pathways for Testis Seminoma

GO Terms for Testis Seminoma

Cellular components related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 9.33 ALPI ALPL ALPP
2 nuclear heterochromatin GO:0005720 8.96 DNMT3A H2AFZ
3 apical plasma membrane GO:0016324 8.92 SLC2A1 SLC2A2 SLC2A5 TJP1

Biological processes related to Testis Seminoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 dephosphorylation GO:0016311 9.73 ALPI ALPL ALPP PTPRC
2 glutathione derivative biosynthetic process GO:1901687 9.54 GSTM2 HPGDS
3 DNA methylation involved in gamete generation GO:0043046 9.52 DNMT3A DNMT3L
4 response to vitamin A GO:0033189 9.51 DNMT3A DNMT3B
5 intermediate filament organization GO:0045109 9.49 AGFG1 GFAP
6 regulation of gene expression by genetic imprinting GO:0006349 9.48 DNMT3A DNMT3L
7 hexose transmembrane transport GO:0008645 9.46 SLC2A2 SLC2A6
8 C-5 methylation of cytosine GO:0090116 9.4 DNMT3A DNMT3B
9 dehydroascorbic acid transport GO:0070837 9.37 SLC2A1 SLC2A2
10 DNA methylation GO:0006306 9.33 DNMT3A DNMT3B DNMT3L
11 DNA methylation on cytosine GO:0032776 9.32 DNMT3A DNMT3L
12 intestinal hexose absorption GO:0106001 9.26 SLC2A2 SLC2A5
13 carbohydrate transport GO:0008643 9.26 SLC2A1 SLC2A2 SLC2A5 SLC2A6
14 glucose transmembrane transport GO:1904659 8.92 SLC2A1 SLC2A2 SLC2A5 SLC2A6

Molecular functions related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.67 SLC2A1 SLC2A2 SLC2A5 SLC2A6
2 phosphatase activity GO:0016791 9.62 ALPI ALPL ALPP PTPRC
3 glutathione transferase activity GO:0004364 9.48 GSTM2 HPGDS
4 dehydroascorbic acid transmembrane transporter activity GO:0033300 9.43 SLC2A1 SLC2A2
5 DNA-methyltransferase activity GO:0009008 9.4 DNMT3A DNMT3B
6 D-glucose transmembrane transporter activity GO:0055056 9.33 SLC2A1 SLC2A2 SLC2A6
7 DNA (cytosine-5-)-methyltransferase activity GO:0003886 9.26 DNMT3A DNMT3B
8 alkaline phosphatase activity GO:0004035 9.13 ALPI ALPL ALPP
9 glucose transmembrane transporter activity GO:0005355 8.92 SLC2A1 SLC2A2 SLC2A5 SLC2A6
10 protein binding GO:0005515 10.39 AGFG1 ALPI ALPL ALPP DNMT3A DNMT3B

Sources for Testis Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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