MCID: TST020
MIFTS: 34

Testis Seminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Testis Seminoma

MalaCards integrated aliases for Testis Seminoma:

Name: Testis Seminoma 12 15
Testicular Seminoma Pure 12
Seminoma of Testis 12
Seminoma Testis 12
Seminoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5842
MeSH 45 D018239
NCIt 51 C7328 C9309
SNOMED-CT 69 36741007
UMLS 74 C0036631

Summaries for Testis Seminoma

MalaCards based summary : Testis Seminoma, also known as testicular seminoma pure, is related to testicular germ cell tumor and testicular seminoma. An important gene associated with Testis Seminoma is DNMT3L (DNA Methyltransferase 3 Like), and among its related pathways/superpathways are NAD metabolism and Folate biosynthesis. The drugs Granisetron and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone marrow and colon, and related phenotype is Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance.

Related Diseases for Testis Seminoma

Diseases related to Testis Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 11.3
2 testicular seminoma 11.3
3 seminoma 10.6
4 cryptorchidism, unilateral or bilateral 10.1
5 spermatocytoma 10.1
6 testicular spermatocytic seminoma 10.1
7 breast cancer 9.9
8 renal cell carcinoma, nonpapillary 9.9
9 enterocolitis 9.9
10 primary amebic meningoencephalitis 9.9
11 germ cell cancer 9.9
12 testicular cancer 9.9
13 gliosarcoma 9.9
14 teratoma 9.9
15 mature teratoma 9.9
16 hydrocele 9.9
17 spinal cord injury 9.9
18 orchitis 9.9
19 ureteral obstruction 9.9
20 paraplegia 9.9
21 tick infestation 9.7 ALPL ALPP
22 hypophosphatasia 9.7 ALPL ALPP
23 hypophosphatasia, infantile 9.6 ALPL ALPP
24 bone disease 9.5 ALPL ALPP
25 testicular malignant germ cell cancer 9.5 ALPP DNMT3L SLC2A5

Graphical network of the top 20 diseases related to Testis Seminoma:



Diseases related to Testis Seminoma

Symptoms & Phenotypes for Testis Seminoma

GenomeRNAi Phenotypes related to Testis Seminoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.8 ALPL ALPP FHL2

Drugs & Therapeutics for Testis Seminoma

Drugs for Testis Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
3
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
5
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
6
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
7
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
8
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
9
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 1177-87-3
12
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
13
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
14
Captopril Approved Phase 3 62571-86-2 44093
15
Ribavirin Approved Phase 3 36791-04-5 37542
16
Palivizumab Approved, Investigational Phase 3 188039-54-5
17
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
18
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
19
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
20
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
21
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
22
Ondansetron Approved Phase 3 99614-02-5 4595
23
Promethazine Approved, Investigational Phase 3 60-87-7 4927
24
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
25
Vinblastine Approved Phase 3 865-21-4 241903 13342
26 Serotonin Antagonists Phase 3
27 Antiemetics Phase 3,Phase 2
28 Serotonin Agents Phase 3
29 Neurotransmitter Agents Phase 3
30 Gastrointestinal Agents Phase 3,Phase 2
31 Autonomic Agents Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 3,Phase 2
33 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
34 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
35 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
36 Etoposide phosphate Phase 2, Phase 3,Phase 3
37 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
38 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
39 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
40 Immunologic Factors Phase 3,Phase 1,Phase 2
41 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
42 Alkylating Agents Phase 3,Phase 1,Phase 2
43 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
44 Antiviral Agents Phase 3,Phase 1,Phase 2
45 Anti-Infective Agents Phase 3,Phase 1,Phase 2
46 Antimetabolites Phase 3,Phase 1,Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
48 Hormone Antagonists Phase 3,Phase 2,Phase 1
49 Hormones Phase 3,Phase 2,Phase 1
50
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
2 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
5 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
7 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
8 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
10 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
12 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
13 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
14 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
16 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
17 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
18 Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma Completed NCT02272816 Phase 2 Carboplatin AUC-10
19 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
20 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
21 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
22 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
23 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
24 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
25 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
26 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
27 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
28 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
29 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
30 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
31 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
32 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
33 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
34 Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
35 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
36 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
37 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
38 Therapy De-escalation in Seminoma Stage IIA/B Active, not recruiting NCT01593241 Phase 2 Carboplatin
39 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Active, not recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
40 Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma Not yet recruiting NCT03937843 Phase 2 Carboplatin;Cisplatin;Etoposide
41 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
42 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
43 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
44 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
45 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
46 Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle Unknown status NCT02873793
47 REtrospective Study of TESTIcular CAncer Patients at the University Magdeburg Completed NCT02092740
48 Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients Completed NCT00705094
49 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
50 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable

Search NIH Clinical Center for Testis Seminoma

Genetic Tests for Testis Seminoma

Anatomical Context for Testis Seminoma

MalaCards organs/tissues related to Testis Seminoma:

42
Testis, Bone Marrow, Colon, Lymph Node, Small Intestine, Spinal Cord

Publications for Testis Seminoma

Articles related to Testis Seminoma:

# Title Authors Year
1
Rare late metastasis of testis seminoma to the bladder. ( 26600894 )
2015
2
Treatment of stage I testis seminoma by radiotherapy: long-term results--a 30-year experience. ( 8365943 )
1993
3
Positive hydrocele cytology accompanying testis seminoma. ( 1546428 )
1992
4
A patient with testis seminoma, sarcoidosis, and neutropenic enterocolitis. ( 6714970 )
1984
5
Rupture of the testis: seminoma. ( 13364269 )
1956

Variations for Testis Seminoma

Expression for Testis Seminoma

Search GEO for disease gene expression data for Testis Seminoma.

Pathways for Testis Seminoma

Pathways related to Testis Seminoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.4 ALPL ALPP
2
Show member pathways
10.42 ALPL ALPP
3 9.83 ALPL ALPP

GO Terms for Testis Seminoma

Cellular components related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 8.62 ALPL ALPP

Biological processes related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dephosphorylation GO:0016311 8.96 ALPL ALPP
2 osteoblast differentiation GO:0001649 8.62 ALPL FHL2

Molecular functions related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatase activity GO:0016791 8.96 ALPL ALPP
2 alkaline phosphatase activity GO:0004035 8.62 ALPL ALPP

Sources for Testis Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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