MCID: TST020
MIFTS: 28

Testis Seminoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Testis Seminoma

MalaCards integrated aliases for Testis Seminoma:

Name: Testis Seminoma 12 15
Testicular Seminoma Pure 12
Seminoma of Testis 12
Seminoma Testis 12
Seminoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5842
MeSH 43 D018239
NCIt 49 C9309
SNOMED-CT 67 36741007 443675005
UMLS 71 C0036631

Summaries for Testis Seminoma

MalaCards based summary : Testis Seminoma, also known as testicular seminoma pure, is related to testicular germ cell tumor and seminoma. An important gene associated with Testis Seminoma is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1). The drugs Granisetron and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone marrow and bone.

Related Diseases for Testis Seminoma

Diseases related to Testis Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 11.8
2 seminoma 10.6
3 teratoma 10.2
4 renal cell carcinoma, nonpapillary 10.1
5 germ cell cancer 10.1
6 mature teratoma 10.1
7 germ cells tumors 10.1
8 spermatocytoma 10.1
9 testicular spermatocytic seminoma 10.1
10 sarcoidosis 1 9.9
11 cryptorchidism, unilateral or bilateral 9.9
12 enterocolitis 9.9
13 kidney cancer 9.9
14 testicular cancer 9.9
15 gliosarcoma 9.9
16 malignant teratoma 9.9
17 lymphopenia 9.9
18 intermediate malignant teratoma 9.9
19 hydrocele 9.9
20 hypereosinophilic syndrome 9.9
21 nonseminomatous germ cell tumor 9.9
22 testicular seminoma 9.9
23 orchitis 9.9
24 ureteral obstruction 9.9
25 extragonadal seminoma 9.9
26 paraplegia 9.9
27 spinal cord injury 9.9
28 granular cell carcinoma 9.7 PBOV1 HHLA1
29 papillary transitional carcinoma 9.6 PBOV1 HHLA1

Graphical network of the top 20 diseases related to Testis Seminoma:



Diseases related to Testis Seminoma

Symptoms & Phenotypes for Testis Seminoma

Drugs & Therapeutics for Testis Seminoma

Drugs for Testis Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Captopril Approved Phase 3 62571-86-2 44093
4
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
5
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Ribavirin Approved Phase 3 36791-04-5 37542
9
Palivizumab Approved, Investigational Phase 3 188039-54-5
10
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
11
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
12
Ondansetron Approved Phase 3 99614-02-5 4595
13
Etoposide Approved Phase 3 33419-42-0 36462
14
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
15
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
16
Lenograstim Approved, Investigational Phase 3 135968-09-1
17
Mesna Approved, Investigational Phase 3 3375-50-6 598
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
19
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
20
Promethazine Approved, Investigational Phase 3 60-87-7 4927
21
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
22
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
23
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
24
Ifosfamide Approved Phase 3 3778-73-2 3690
25
Vinblastine Approved Phase 3 865-21-4 241903 13342
26 Gastrointestinal Agents Phase 3
27 Antiemetics Phase 3
28 Neurotransmitter Agents Phase 3
29 Anti-Infective Agents Phase 3
30 Immunosuppressive Agents Phase 3
31 Antiviral Agents Phase 3
32 Antimetabolites Phase 3
33 Liver Extracts Phase 3
34 Antirheumatic Agents Phase 3
35 Antihypertensive Agents Phase 3
36 Angiotensin-Converting Enzyme Inhibitors Phase 3
37 HIV Protease Inhibitors Phase 3
38
protease inhibitors Phase 3
39 Cytochrome P-450 Enzyme Inhibitors Phase 3
40 Hormone Antagonists Phase 3
41 Hormones Phase 3
42
Hydroxyitraconazole Phase 3
43 Antifungal Agents Phase 3
44 Cytochrome P-450 CYP3A Inhibitors Phase 3
45 glucocorticoids Phase 3
46 Cola Phase 3
47 Anti-Inflammatory Agents Phase 3
48 Antineoplastic Agents, Hormonal Phase 3
49 Amebicides Phase 3
50 Antiparasitic Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
2 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
5 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
6 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
7 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
8 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
10 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
11 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 A Randomized Phase III Double-Blind Study Of Ondansetron And Dexamethasone Versus Ondansetron And Placebo In The Prophylaxis Of Radiation-Induced Emesis Completed NCT00016380 Phase 3 dexamethasone;ondansetron
13 A Randomized Phase III Study Comparing One Course of Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) and One Course of Carboplatin AUC7 in Clinical Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
14 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
16 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
17 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
18 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
19 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
20 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
21 Multicenter Phase 2 Trial of ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
22 A Multi-Centre Phase II Study Using Carboplatin AUC-10 for Metastatic Seminoma With IGCCCG Good Prognosis Disease-Therapy Directed by Initial Metabolic Response on PET-CT Completed NCT02272816 Phase 2 Carboplatin AUC-10
23 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
24 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
25 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
26 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
27 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
28 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
29 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
30 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
31 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
32 A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
33 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
34 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
35 Phase II Study of Avelumab in Multiple Relapsed/Refractory Testicular Germ Cell Cancer. Completed NCT03403777 Phase 2 Avelumab
36 Therapeutic Strategy Guided by PET-TDM for Patients With Grade I or Metastatic Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
37 Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma. A Multicenter, Open Label Phase II Trial With Two Cohorts Recruiting NCT03937843 Phase 2 Carboplatin;Cisplatin;Etoposide
38 A Single-arm, Phase II Study of Durvalumab (MEDI4736) and Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
39 A Prospective,Multicenter, Phase II Study to Evaluate the Contribution of the Imaging TEP to the Expression of intégrines αvβ3 for the Characterization of the Residual Masses of Non-seminoma Tumors at the End of Chemotherapy Recruiting NCT02317393 Phase 2
40 Phase II Single-arm Trial to Evaluate Progression Free Survival With Primary Retroperitoneal Lymph-node Dissection (pRPLND) Only in Patients With Seminomatous Testicular Germ Cell Tumors With Clinical Stage IIA/B (PRIMETEST) Recruiting NCT02797626 Phase 2
41 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
42 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
43 Carboplatin Chemotherapy and Involved Node Radiotherapy in Stage IIA/B Seminoma Active, not recruiting NCT01593241 Phase 2 Carboplatin
44 A Phase II Study Of Imatinib Mesylate (Gleevec, Formerly Known As STI571; IND 61,135, NSC #716051) In Patients With Refractory Seminoma Terminated NCT00042952 Phase 2 imatinib mesylate
45 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
46 Phase II Multi-institutional Proof of Concept Single-arm Trial of Nivolumab in the Treatment of Patients With Platinum Recurrent or Refractory Metastatic Germ Cell Tumors Withdrawn NCT03726281 Phase 2 Nivolumab
47 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
48 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
49 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
50 Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours: Potential Risks and Consequences for the Conceptus Unknown status NCT03262207

Search NIH Clinical Center for Testis Seminoma

Genetic Tests for Testis Seminoma

Anatomical Context for Testis Seminoma

MalaCards organs/tissues related to Testis Seminoma:

40
Testis, Bone Marrow, Bone, Lymph Node, Liver, Kidney, Lung

Publications for Testis Seminoma

Articles related to Testis Seminoma:

(show all 24)
# Title Authors PMID Year
1
Supraclavicular left neck mass: an unusual presentation of metastatic testicular cancer in two older men. 61
32327457 2020
2
Radiotherapy in testicular germ cell tumours - a literature review. 61
29180926 2017
3
Rare late metastasis of testis seminoma to the bladder. 61
26600894 2015
4
Expression and Localization of Lung Surfactant Proteins in Human Testis. 61
26599233 2015
5
The more you look, the more you find: challenging results on FDG-PET CT in a patient with neurofibromatosis type I. 61
24885974 2014
6
[Autoimmune encephalitis, clinical, radiological and immunological data]. 61
23099105 2013
7
[Stage I seminoma and radiotherapy: to bury it or not?]. 61
18760650 2008
8
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. 61
16523487 2006
9
[Case of NASH exacerbated after testectomy due to seminoma]. 61
15387271 2004
10
[Clinical presentation, treatment, and follow-up of 32 patients with a primary intracranial germinoma, registered during the previous 15 years in the Dutch Pathological-Anatomical National Automated Archive (PALGA)]. 61
11109472 2000
11
[Therapeutic strategy in stage I seminomas: which lymph node areas are to be irradiated?]. 61
10212959 1999
12
[CT findings of metastatic and primary neoplasms of the kidney: a comparative study]. 61
11776798 1999
13
Establishment and characterization of a new human testicular seminoma cell line, JKT-1. 61
9624562 1998
14
Respiratory syncytial virus, a rare cause of severe pneumonia following bone marrow transplantation. 61
7492628 1995
15
Treatment of stage I testis seminoma by radiotherapy: long-term results--a 30-year experience. 61
8365943 1993
16
[Histopathological study of intracranial germinoma]. 61
8403104 1993
17
Early detection of relapse after treatment for metastatic germ cell tumour of the testis: an exercise in medical audit. 61
7678749 1993
18
Positive hydrocele cytology accompanying testis seminoma. 61
1546428 1992
19
Glutathione transferase isoenzymes from human testis. 61
2688647 1989
20
A patient with testis seminoma, sarcoidosis, and neutropenic enterocolitis. 61
6714970 1984
21
Seminoma in childhood. 61
6108374 1980
22
[Clonal analysis of a transplantable rat seminoma]. 61
462547 1979
23
Primary malignant germinal tumors of the mediastinum. A study of 24 cases. 61
1237349 1975
24
Rupture of the testis: seminoma. 61
13364269 1956

Variations for Testis Seminoma

Expression for Testis Seminoma

Search GEO for disease gene expression data for Testis Seminoma.

Pathways for Testis Seminoma

GO Terms for Testis Seminoma

Biological processes related to Testis Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA splicing, via spliceosome GO:0000398 8.8 U2AF1 RBM6 RBM5

Sources for Testis Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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