Tetanus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TTN003 MIFTS: 65	Tetanus Categories: Bone diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases
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Aliases & Classifications for Tetanus

MalaCards integrated aliases for Tetanus:

Name: Tetanus ¹² ⁷⁴ ⁵² ⁵⁸ ⁵⁴ ⁴² ⁴³ ¹⁵ ¹⁷ ⁷¹

Lockjaw ⁵² ³

Infection Due to Clostridium Tetani ¹²

Clostridial Tetanus ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁸

tetanus
Prevalence: <1/1000000 (France),<1/1000000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases Bone diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Certain infectious and parasitic diseases

Other bacterial diseases

Obstetrical tetanus

Other tetanus

Tetanus neonatorum

Orphanet: ⁵⁸

Rare neurological diseases

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:11338

ICD9CM ³⁴ 037

MeSH ⁴³ D013742

NCIt ⁴⁹ C85185

SNOMED-CT ⁶⁷ 76902006

ICD10 ³² A35

MESH via Orphanet ⁴⁴ D013742

ICD10 via Orphanet ³³ A33 A34 A35

UMLS via Orphanet ⁷² C0039614

Orphanet ⁵⁸ ORPHA3299

EFO ¹⁷ EFO_0005593

UMLS ⁷¹ C0039614

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Summaries for Tetanus

MedlinePlus : ⁴² Tetanus is a serious illness caused by Clostridium bacteria. The bacteria live in soil, saliva, dust, and manure. The bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. The infection causes painful tightening of the muscles, usually all over the body. It can lead to "locking" of the jaw. This makes it impossible to open your mouth or swallow. Tetanus is a medical emergency. You need to get treatment in a hospital. A vaccine can prevent tetanus. It is given as a part of routine childhood immunization. Adults should get a tetanus shot, or booster, every 10 years. If you get a bad cut or burn, see your doctor - you may need a booster. Immediate and proper wound care can prevent tetanus infection.

MalaCards based summary : Tetanus, also known as lockjaw, is related to diphtheria and poliomyelitis, and has symptoms including fever and pruritus. An important gene associated with Tetanus is VAMP2 (Vesicle Associated Membrane Protein 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Remifentanil and Natalizumab have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and skeletal muscle, and related phenotypes are dysphagia and muscle stiffness

Disease Ontology : ¹² A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

CDC : ³ Tetanus is different from other vaccine-preventable diseases because it does not spread from person to person. The bacteria are usually found in soil, dust, and manure and enter the body through breaks in the skin - usually cuts or puncture wounds caused by contaminated objects. Today, tetanus is uncommon in the United States, with an average of about 30 reported cases each year. Nearly all cases of tetanus are among people who did not get all the recommended tetanus vaccinations. This includes people who have never received a tetanus vaccine and adults who don't stay up to date on their 10-year booster shots.

Wikipedia : ⁷⁴ Tetanus, also known as lockjaw, is a bacterial infection characterized by muscle spasms. In the most... more...

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Related Diseases for Tetanus

Diseases related to Tetanus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 782)

#	Related Disease	Score	Top Affiliating Genes
1	diphtheria	33.3	IL5 IL4 IL2RA IL2 IL13 IFNG
2	poliomyelitis	32.3	IL4 IL10 IFNG CD40LG
3	measles	31.8	IL2RA IL2 IFNG CD40LG
4	typhoid fever	31.7	LTA IFNG CD40LG
5	foodborne botulism	31.7	VAMP2 SNAP25 NSF
6	mumps	31.6	IL2RA IL2 IL10 IFNG CD40LG
7	rubella	31.4	IL5 IL4 IL2RA IL2 IL10 IFNG
8	allergic hypersensitivity disease	31.4	IL5 IL4 IL2 IL13 IL10 IFNG
9	smallpox	31.4	IL4 IL2 IFNG
10	respiratory failure	31.3	LTA IL5 IL13 IL10 CD40LG
11	hepatitis a	31.2	IL4 IL10 IFNG
12	neuritis	31.2	IL4 IL10 IFNG
13	graft-versus-host disease	31.1	IL2 IL10 IFNG
14	myelitis	31.1	IL10 CD40LG CD27
15	leprosy 3	31.0	IL5 IL4 IL2 IL10 IFNG CD40LG
16	cytokine deficiency	31.0	IL5 IL13
17	chickenpox	31.0	IL4 IL2 IL10 IFNG CD40LG CD27
18	lepromatous leprosy	31.0	IL4 IL2 IL10 IFNG
19	myocarditis	30.9	IL4 IL2 IL10 IFNG CD40LG
20	peripheral nervous system disease	30.9	IL4 IL2 IL10 IFNG CD40LG
21	exanthem	30.9	IL2 IL10 IFNG CD40LG
22	herpes zoster	30.9	IL2 IL10 IFNG CD40LG
23	purpura	30.9	IL4 IL10 IFNG CD79A CD40LG
24	onchocerciasis	30.9	IL5 IL4 IL2 IL13
25	otitis media	30.9	IL5 IL4 IL2 IL13 IL10 IFNG
26	wound botulism	30.9	VAMP2 SNAP25 NSF
27	erythema multiforme	30.9	IL5 IL4 IL2 IL13 IFNG
28	urticaria	30.8	IL5 IL4 IL13 IL10 CD40LG
29	yellow fever	30.8	LTA IL5 IL4
30	ige responsiveness, atopic	30.8	IL5 IL4 IL13 IL10 IFNG
31	elephantiasis	30.8	IL5 IL4 IL13 IL10
32	dermatitis	30.8	IL5 IL4 IL2 IL13 IL10 IFNG
33	viral hepatitis	30.8	IL4 IL2 IL10 IFNG CD40LG
34	optic neuritis	30.8	LTA IL2RA IL10
35	meningitis	30.8	IL5 IL4 IL2 IL13 IL10 IFNG
36	complex regional pain syndrome	30.8	IL2 IL10 IFNG
37	demyelinating disease	30.7	IL4 IL2 IL10 IFNG CD40LG
38	infant botulism	30.7	VAMP2 SNAP25 NSF
39	schistosomiasis	30.7	IL5 IL4 IL2 IL13 IL10 IFNG
40	chronic graft versus host disease	30.7	IL2RA IL10 IFNG CD79A
41	osteomyelitis	30.7	IL4 IL13 IL10 IFNG
42	human immunodeficiency virus type 1	30.7	LTA IL2 IL10 IFNG CCR7
43	gastroenteritis	30.7	IL5 IL4 IL10 IFNG
44	myasthenia gravis	30.7	LTA IL4 IL2 IL10 IFNG CD40LG
45	cellulitis	30.7	IL5 IL4 IL2 IL10 IFNG CD40LG
46	arthritis	30.7	LTA IL4 IL13 IL10 IFNG
47	thrombocytopenia	30.6	LTA IL4 IL2 IL10 IFNG CD79A
48	lichen planus	30.6	IL4 IL2 IL10 IFNG
49	wells syndrome	30.6	IL5 IL2RA IL2
50	hemolytic anemia	30.6	IL4 IL2 IL10 IFNG CD40LG

Graphical network of the top 20 diseases related to Tetanus:

Sources

Symptoms & Phenotypes for Tetanus

Human phenotypes related to Tetanus:

⁵⁸ ³¹ (show all 30)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	dysphagia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002015
2	muscle stiffness ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0003552
3	trismus ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000211
4	opisthotonus ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002179
5	risus sardonicus ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0040212
6	fever ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001945
7	rigidity ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002063
8	tachycardia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001649
9	intermittent painful muscle spasms ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0011964
10	localized skin lesion ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0011355
11	stiff neck ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0025258
12	humoral immunodeficiency ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0005363
13	cranial nerve paralysis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0006824
14	elevated serum creatine kinase ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003236
15	tremor ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001337
16	abdominal pain ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002027
17	bowel incontinence ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002607
18	hypertension ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000822
19	tachypnea ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002789
20	respiratory distress ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002098
21	coma ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001259
22	bradycardia ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001662
23	autonomic bladder dysfunction ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0005341
24	laryngospasm ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0025425
25	elevated urinary norepinephrine ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003345
26	elevated urinary epinephrine ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003639
27	rigors ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0025145
28	spasticity of pharyngeal muscles ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002501
29	hypertonia ⁵⁸		Frequent (79-30%)
30	abnormal autonomic nervous system physiology ⁵⁸		Occasional (29-5%)

UMLS symptoms related to Tetanus:

fever, pruritus

GenomeRNAi Phenotypes related to Tetanus according to GeneCards Suite gene sharing:

²⁶ (show all 47)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.2	IL10 CCR7
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-104	10.2	IL2RA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	10.2	IL13
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.2	IL10
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.2	IL2RA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-119	10.2	CCR7
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.2	IL2RA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-125	10.2	IL10
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	10.2	VAMP7
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	10.2	IL2RA
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	10.2	VAMP7
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	10.2	IL2RA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	10.2	NSF
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.2	IL10
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.2	VAMP7
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.2	IL10
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-165	10.2	IL13
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-172	10.2	CCR7
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	10.2	IL2RA
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-179	10.2	NSF VAMP7
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-181	10.2	IL13
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-191	10.2	VAMP7
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	10.2	IL10
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	10.2	IL13
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	10.2	IL2RA
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	10.2	NSF
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-210	10.2	IL10
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.2	IL10
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	10.2	CCR7
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.2	IL2RA
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	10.2	NSF
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-34	10.2	IL2RA
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.2	VAMP7
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	10.2	IL2RA
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	10.2	VAMP7
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-5	10.2	NSF
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.2	IL10 IL2RA
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	10.2	IL10
39	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.2	IL13
40	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.2	VAMP7
41	Increased shRNA abundance (Z-score > 2)	GR00366-A-65	10.2	IL10
42	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	10.2	IL10 IL2RA
43	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	10.2	IL10
44	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.2	VAMP7
45	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	10.2	IL10
46	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.2	IL10
47	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	10.2	NSF

MGI Mouse Phenotypes related to Tetanus:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.31	CCR7 CD27 CD40LG CD79A IFNG IL10
2	homeostasis/metabolism	MP:0005376	10.25	CCR7 CD40LG CD79A IFNG IL10 IL13
3	immune system	MP:0005387	10.24	CCR7 CD27 CD40LG CD79A IFNG IL10
4	endocrine/exocrine gland	MP:0005379	10.2	CCR7 CD40LG IFNG IL10 IL13 IL2
5	mortality/aging	MP:0010768	10.13	CD40LG CD79A IFNG IL10 IL13 IL2
6	digestive/alimentary	MP:0005381	10.08	CCR7 IFNG IL10 IL13 IL2 IL2RA
7	nervous system	MP:0003631	9.93	CCR7 CD40LG CD79A IFNG IL10 IL13
8	liver/biliary system	MP:0005370	9.92	CD79A IFNG IL10 IL2 IL4 IL5
9	no phenotypic analysis	MP:0003012	9.61	CCR7 CD79A IFNG IL10 IL13 IL2
10	respiratory system	MP:0005388	9.28	IFNG IL10 IL13 IL2 IL2RA IL4

Sources

Drugs & Therapeutics for Tetanus

Drugs for Tetanus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 306)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Remifentanil

Approved

Phase 4

132875-61-7

60815

Natalizumab

Approved, Investigational

Phase 4

189261-10-7

Adalimumab

Approved

Phase 4

331731-18-1

16219006

Rocuronium

Approved

Phase 4

119302-91-9, 143558-00-3

441290

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Levobupivacaine

Approved, Investigational

Phase 4

27262-47-1

92253

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Desflurane

Approved

Phase 4

57041-67-5

42113

Neostigmine

Approved, Vet_approved

Phase 4

59-99-4

4456

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

Etanercept

Approved, Investigational

Phase 4

185243-69-0

Cisatracurium

Approved

Phase 4

96946-41-7

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Maraviroc

Approved, Investigational

Phase 4

376348-65-1

3002977

Efavirenz

Approved, Investigational

Phase 4

154598-52-4

64139

Ritonavir

Approved, Investigational

Phase 4

155213-67-5

392622

Lopinavir

Approved

Phase 4

192725-17-0

92727

Emtricitabine

Approved, Investigational

Phase 4

143491-57-0

60877

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Tenofovir

Experimental, Investigational

Phase 4

147127-20-6

464205

Antitoxins

Phase 4

Adjuvants, Immunologic

Phase 4

Interleukin 1 Receptor Antagonist Protein

Phase 4

Aluminum phosphate

Phase 4

Gastrointestinal Agents

Phase 4

MF59 oil emulsion

Phase 4

Anesthetics, Local

Phase 4

Cholinergic Agents

Phase 4

Anti-Inflammatory Agents

Phase 4

Analgesics, Opioid

Phase 4

Platelet Aggregation Inhibitors

Phase 4

Cholinesterase Inhibitors

Phase 4

Neuromuscular Blocking Agents

Phase 4

Muscarinic Antagonists

Phase 4

Cholinergic Antagonists

Phase 4

Anesthetics, Inhalation

Phase 4

Glycopyrrolate

Phase 4

596-51-0

3494

Citrate

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

glutamine

Phase 4

Narcotics

Phase 4

Antibiotics, Antitubercular

Phase 4

Amoxicillin-Potassium Clavulanate Combination

Phase 4

beta-Lactamase Inhibitors

Phase 4

Chrysanthemum

Phase 4

Rho(D) Immune Globulin

Phase 4

gamma-Globulins

Phase 4

Anti-Infective Agents

Phase 4

Anti-Retroviral Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 614)

#	Name	Status	NCT ID	Phase	Drugs
1	Open Label Multicentric Randomized Phase IV Post Marketing Safety, Immunogenicity and Lot-to-Lot Consistency Analysis of Shan 5 [DTPwHB-Hib (Liquid) Pentavalent Combination Vaccine] in Indian Infants	Unknown status	NCT00877357	Phase 4
2	The Efficacy and Safety of Vaccination Against Pertussis. Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis	Unknown status	NCT01301703	Phase 4
3	Safety and Immunogenicity of Adult Formulation Tetanus and Diphtheria Toxoids Adsorbed Combined With Acellular Pertussis (Tdap) Vaccine Following Blood and Morrow Transplantation in Adults	Unknown status	NCT00336115	Phase 4
4	An Immunogenicity and Safety Study of Combined Adsorbed Tetanus, Low Dose Diphtheria and Acellular Pertussis Vaccine (Td5ap and Td1aP) Given as a School-leaving Booster to 14-15-year-old Children Primed With a Five Component Acellular Pertussis Vaccine at 3, 5 and 12 Months of Age, and a Booster Dose at 5½ Years of Age	Unknown status	NCT00870350	Phase 4
5	Clinical Study to Generate a Set of Data Characterising Clinical Events, Physiological Responses, and Innate and Adaptive Immune Responses Following a Single IM Immunisation With Boostrix® or Placebo in Healthy Adults	Unknown status	NCT02555540	Phase 4
6	The Influence of BCG Vaccine as a Booster TDaP-IPV Vaccination: an Explorative Study	Unknown status	NCT02771782	Phase 4
7	Safety Among Adolescents and Adults of Revaccination With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Adacel®) 4 to 5 Years After a Previous Dose	Completed	NCT00347958	Phase 4
8	An Open Label Multicentric Study to Evaluate the Immunogenicity and Safety of Indigenously Developed DTPwHB-Hib (Liquid) Pentavalent Combination Vaccine (Shan 5) in Indian Infants.	Completed	NCT00617812	Phase 4
9	A Single Blind, Multicentric, Comparative, Vaccine Interchangeability Trial of Shan 5 (Liquid) and Easy Five (Liquid) [Diphtheria-Tetanus- Pertussis, Hepatitis B and Hib Pentavalent Combination Vaccines] in Indian Infants.	Completed	NCT00674908	Phase 4
10	Comparison in US Adolescents of the Safety and Immunogenicity of Two Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccines: ADACEL™ and BOOSTRIX®	Completed	NCT00319553	Phase 4
11	Immune Responses in Adults to Revaccination With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (ADACEL®) 10 Years After a Previous Dose	Completed	NCT00712959	Phase 4
12	Regulatory Post-Marketing Surveillance (PMS) Study for ADACEL™ (Adsorbed Diphtheria, Tetanus Toxoids and Component Pertussis Combined Vaccine for Adult)	Completed	NCT01137435	Phase 4
13	Antibody Persistence in 11 to 13-year-old Children Previously Vaccinated at 6 Years Old With Either REVAXIS or DT Polio, and Immune Response to a Booster Dose of TETRAVAC-ACELLULAIRE	Completed	NCT01546909	Phase 4
14	Immunogenicity and Safety of Canadian Manufactured Tetanus and Diphtheria Toxoids Adsorbed (Td) for Adult Use Vaccine Compared With U.S. Manufactured Tetanus and Diphtheria Toxoids Adsorbed for Adult Use Vaccine In Persons 60 Years of Age and Older and Immunogenicity and Safety of Canadian Td Vaccine in Persons 11 Through 59 Years of Age	Completed	NCT00601835	Phase 4
15	Open Clinical Study to Assess the Immune Response and Safety of a Booster Dose (5th Dose) of a Combination Vaccine Against Diphteria-Tetanus-Pertussis-Polio Given to Healthy Adolescents 15-16 Years of Age.	Completed	NCT00514059	Phase 4	Boostrix polio
16	A Phase IV, Single-blind, Randomized, Controlled, Monocentric Study to Assess the Interchangeability of Quinvaxem (DTwP-HepB-Hib) as the 2nd and 3rd Dose After Initial Vaccination With Tritanrix HB+Hib (DTwP-HepB/Hib) With Respect to Safety and Immunogenicity in Healthy Infants at 6, 10 and 14 Weeks of Age	Completed	NCT01357720	Phase 4
17	Safety and Immunogenicity of Adacel® Vaccine Administered to Persons 10 Years of Age	Completed	NCT01311557	Phase 4
18	Immunogenicity of Adacel® and BOOSTRIX® Vaccines in Adolescents	Completed	NCT01629589	Phase 4
19	Reactogenicity of Acellular Pertussis Vaccine Booster in Adolescents Who Have Received 5 Prior Doses of BIKEN Acellular Pertussis Vaccine in Combination With Diphtheria and Tetanus Toxoids (TRIPEDIA®) or Who Have Received Primary Vaccination With 3 Doses of Whole-Cell Pertussis Vaccine, Plus at Least 1 Pertussis Booster Vaccination	Completed	NCT00304265	Phase 4
20	Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous Dose	Completed	NCT01439165	Phase 4
21	Post-marketing, Randomized, Open-label Study to Assess the Immunogenicity and Safety of Concomitant Administration of V260 and Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Japanese Healthy Infants	Completed	NCT01926015	Phase 4
22	A Multicenter, Double-Blind, Randomized, Placebo Controlled Study to Estimate the Effect of Anakinra (r-metHuIL-1ra) on Vaccine Antibody Response in Subjects With Rheumatoid Arthritis (RA)	Completed	NCT00111410	Phase 4	Anakinra (r-metHuIL-1ra)
23	Regulatory Post-Marketing Surveillance (PMS) Study for TETRAXIM™(Combined Vaccine of Adsorbed Diphtheria, Tetanus, Acellular Pertussis and Enhanced Inactivated Poliomyelitis)	Completed	NCT01437423	Phase 4
24	Safety and Immunogenicity of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (ADACEL®) in Persons ≥65 Years of Age	Completed	NCT00457249	Phase 4
25	Evaluation of GSK Biologicals' dTpa Booster Vaccine in Young Adults 10 Years After Previous dTpa Boosting.	Completed	NCT00610168	Phase 4
26	Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand	Completed	NCT00255021	Phase 4
27	Evaluation of GSK Biological's dTpa-IPV Booster Vaccine in Children and Adolescents, 5 Years After Previous dTpa-IPV Boosting.	Completed	NCT00635128	Phase 4
28	Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine After Concomitant Vaccination in ≥50-year-old Adults	Completed	NCT03552445	Phase 4
29	Immunogenicity and Safety Study of a Booster Dose of GSK Biologicals' Infanrix Hexa™ (217744) in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery	Completed	NCT02853929	Phase 4
30	Phase IV, Open Label Trial to Evaluate Immunogenicity of Tdap Vaccine in Post-Partum Women to Optimize Vaccination Schedule for Women Who May Have a Subsequent Child	Completed	NCT01711645	Phase 4
31	Immunogenicity and Safety of the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus (DPT-IPV) Vaccine Squarekids Co-administered With GSK Biologicals' Human Rotavirus (HRV) Vaccine Rotarix (GSK444563) in Healthy Infants	Completed	NCT02907216	Phase 4
32	Safety and Immunogenicity of DAPTACEL® (CP10/5/5/3DT Aventis Pasteur 5-component Pertussis Vaccine in Combination With Tetanus and Diphtheria Toxoids Adsorbed) Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ (HCP20/20/5/3DT-mIPV//PRP-T)	Completed	NCT00802867	Phase 4
33	Immunogenicity and Safety of Meningococcal (Groups A, C, Y, and W-135) Diphtheria Toxoid Conjugate Vaccine (Menactra®) in Adolescents in the US When Administered Concomitantly With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap Vaccine)	Completed	NCT00777257	Phase 4
34	Immunogenicity and Safety of the Sanofi Pasteur's DTacP-IPV Combined Vaccine (TETRAXIM™) Given as a Booster Dose at 4 to 6 Years of Life in Children Previously Vaccinated With PENTAXIM™ in the Study E2I34	Completed	NCT01031303	Phase 4
35	Safety & Immunogenicity of a Booster Dose of dTPa Vaccine (Boostrix®) Co-admnd. With Aventis Pasteur's Meningococcal (Serogroups A, C, Y and W-135) Polysaccharide Vaccine (Menactra™) vs Admn. of Either Vaccine Alone in Healthy Adolescents	Completed	NCT00282295	Phase 4
36	Double Strategy to Induce and Expand the T Cell Repertoire by the Administration of Growth Hormone and Vaccination in HIV-1 Infected Patients	Completed	NCT00287677	Phase 4	HAART
37	Antibody Persistence in Children Previously Vaccinated With Three Doses of Infanrix Hexa™ or Infanrix-IPV/Hib™	Completed	NCT01358825	Phase 4
38	Evaluation of GSK Biologicals' Boostrix™ Polio in Healthy Adults, 10 Years After a Booster Vaccination	Completed	NCT01323959	Phase 4
39	Randomized, Open Label, Active Control, Parallel Assignment Clinical Trial to Evaluate the Immunogenicity of Polysaccharide Meningococcal C Vaccines Conjugated With Tetanus Toxoid or CRM197 Given as a Booster Dose at 14-18 Months of Life.	Completed	NCT00392808	Phase 4
40	A Phase 4, Randomized, Open-label Trial Evaluating the Safety, Tolerability, and Immunogenicity of DTaP Vaccine in Healthy Infants Given With a 7-valent Pneumococcal Conjugate Vaccine in Japan.	Completed	NCT01250756	Phase 4
41	A Prospective, Randomized, Open-label Clinical Trial to Assess the Safety and Immunogenicity of Simultaneous vs Sequential Administration of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine and Inactivated Influenza Vaccine in Pregnant Women - Pilot	Completed	NCT02783170	Phase 4
42	An Open, Randomized, Multicenter Study of the Safety, Tolerability, and Immunogenicity of VAQTA™ Given Concomitantly With PedvaxHIB™ and Infanrix™ in Healthy Children 15 Months of Age	Completed	NCT00289913	Phase 4
43	A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of a Combined Tetanus, Reduced Diphtheria Toxoid, Acellular Pertussis Vaccine (Tdap, Boostrix®) and Quadrivalent Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine (Gardasil®) in Healthy Adolescents When Administered With MenACWY Conjugate Vaccine	Completed	NCT01424644	Phase 4
44	A Randomised Controlled Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants	Completed	NCT02145624	Phase 4	Repevax;Boostrix-IPV
45	Evaluation of GSK Biologicals' dTpa Booster Vaccine in Adults, Given 10 Years After Previous dTpa Boosting.	Completed	NCT00548171	Phase 4
46	A Randomized, Open-Label Study to Assess the Effects of Tysabri Treatment on Vaccination Response and Lymphocyte Subsets in Subjects With Relapsing Forms of Multiple Sclerosis	Completed	NCT00536120	Phase 4
47	An Open, Multicentric, Post-marketing Surveillance Study to Assess the Safety and Reactogenicity of GlaxoSmithKline Biologicals' DTPa-IPV/Hib Vaccine Administered at 3, 4, 5 and 18 Months of Age, in Healthy Infants.	Completed	NCT00325156	Phase 4
48	A Phase IV (Not Interventional), Open-label, Multicentre Study to Evaluate the Reactogenicity and Safety of Co-administration of GlaxoSmithKline Biologicals' DTPa (Infanrix) and IPV (Poliorix) Vaccines Administered as Three-dose Primary Immunisation Course at 3, 4.5 and 6 Months of Age in Healthy Children in Russian Federation	Completed	NCT01094171	Phase 4
49	A Phase 4, Open-label Study to Evaluate Persistence of the Antibody Response Elicited by Prevenar in Healthy Children in China Who Have Been Previously Immunized With a 4-dose Series of a Pneumococcal Conjugate Vaccine During Infancy in Study 0887x-101518	Completed	NCT01298544	Phase 4
50	Immunogenicity and Safety Study of GSK Biologicals' Combined Diphtheria-tetanus-acellular Pertussis-hepatitis B-inactivated Polio-virus and Haemophilus Influenzae Type b Vaccine (Infanrix Hexa™) (217744) in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery	Completed	NCT02422264	Phase 4	Prevnar13

Search NIH Clinical Center for Tetanus

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Chlorpromazine

Chlorpromazine hydrochloride

cyclobenzaprine

Cyclobenzaprine hydrochloride

Methocarbamol

Metocurine iodide

Orphenadrine

Orphenadrine Citrate

Orphenadrine Hydrochloride

Tetanus Antitoxin

TETANUS ANTITOXIN,EQUINE

Tetanus immune globulin

Tetanus immune globulin, human

tetanus toxoid vaccine, inactivated

Cochrane evidence based reviews: tetanus

Sources

Genetic Tests for Tetanus

Sources

Anatomical Context for Tetanus

MalaCards organs/tissues related to Tetanus:

⁴⁰

T Cells, Testes, Skeletal Muscle, B Cells, Brain, Bone, Skin

Sources

Publications for Tetanus

Articles related to Tetanus:

(show top 50) (show all 23117)

#	Title	Authors	PMID	Year
1	Progress Toward Maternal and Neonatal Tetanus Elimination - Worldwide, 2000-2018. ⁶¹ ⁴²	Njuguna HN...Tohme RA	32352953	2020
2	Fever After Influenza, Diphtheria-Tetanus-Acellular Pertussis, and Pneumococcal Vaccinations. ⁶¹ ⁴²	Walter EB...Broder KR	32029684	2020
3	Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review. ⁴²	Vygen-Bonnet S...Harder T	32054444	2020
4	In vitro cytokine responses to periodontal pathogens: generalized aggressive periodontitis is associated with increased IL-6 response to Porphyromonas gingivalis. ⁵⁴ ⁶¹	Borch TS...Nielsen CH	20500696	2010
5	Failure of highly active antiretroviral therapy in reconstituting immune response to Clostridium tetani vaccine in aged AIDS patients. ⁶¹ ⁵⁴	Andrade RM...Bento CA	20224419	2010
6	CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function. ⁶¹ ⁵⁴	Rivino L...Geginat J	20194631	2010
7	[Conditional cell targeting and reversible synapse silencing to study neural circuits]. ⁶¹ ⁵⁴	Watanabe D	20297730	2010
8	Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients. ⁵⁴ ⁶¹	Pfleger C...p520/521 Study Group	19744828	2010
9	Stimulation of anti-polio and anti-HSV IgA pre-plasma cell response in blood following parenteral immunization with tetanus-diphtheria vaccine. ⁵⁴ ⁶¹	Fernandes JR...Snider DP	20003921	2010
10	Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy. ⁶¹ ⁵⁴	Monfort P...Felipo V	19450629	2009
11	VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. ⁵⁴ ⁶¹	Kean MJ...Coppolino MG	19910495	2009
12	Subcellular localization of the carbohydrate Lewis(x) adhesion structure in hippocampus cell cultures. ⁵⁴ ⁶¹	Brito C...Costa J	19576189	2009
13	T-cell reactivity during tapering of immunosuppression to low-dose monotherapy prednisolone in HLA-identical living-related renal transplant recipients. ⁶¹ ⁵⁴	Gerrits JH...van Besouw NM	19300195	2009
14	The CBD1 peptide corresponding to the caveolin-1 binding domain of HIV-1 glycoprotein gp41 elicits neutralizing antibodies in cynomolgus macaques when administered with the tetanus T helper epitope. ⁶¹ ⁵⁴	Benferhat R...Hovanessian AG	19010547	2009
15	Role of HRB in clathrin-dependent endocytosis. ⁶¹ ⁵⁴	Chaineau M...Galli T	18819912	2008
16	Enhancement of human antigen-specific memory T-cell responses by interleukin-7 may improve accuracy in diagnosing tuberculosis. ⁶¹ ⁵⁴	Feske M...Lewis DE	18753334	2008
17	GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. ⁵⁴ ⁶¹	Randhawa VK...Klip A	18650435	2008
18	The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis. ⁵⁴ ⁶¹	Hedegaard CJ...Nielsen CH	18653385	2008
19	Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region. ⁶¹ ⁵⁴	Kobayashi T...Kobayashi K	18775748	2008
20	Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. ⁶¹ ⁵⁴	Wallden J...ABIS Study Group	18782261	2008
21	Peanut-specific B and T cell responses are correlated in peanut-allergic but not in non-allergic individuals. ⁶¹ ⁵⁴	Turcanu V...Lack G	18564333	2008
22	Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin. ⁶¹ ⁵⁴	Chen S...Barbieri JT	18511417	2008
23	Molecular basis for tetanus toxin coreceptor interactions. ⁶¹ ⁵⁴	Chen C...Barbieri JT	18543947	2008
24	Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes. ⁶¹ ⁵⁴	Huurman VA...Roep BO	18422727	2008
25	A novel, helminth-derived immunostimulant enhances human recall responses to hepatitis C virus and tetanus toxoid and is dependent on CD56+ cells for its action. ⁶¹ ⁵⁴	MacDonald AJ...Rosenberg WM	18341617	2008
26	Effect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-cell proliferation and interleukin 10 production. ⁶¹ ⁵⁴	Burastero SE...Rossi RE	18450120	2008
27	Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. ⁶¹ ⁵⁴	Costantino CM...Ploegh HL	18292509	2008
28	Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. ⁵⁴ ⁶¹	Schneider A...Simons M	18337418	2008
29	Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission. ⁵⁴ ⁶¹	Zhdanov AV...Papkovsky DB	18086678	2008
30	Targeting the epithelial SNARE machinery by bacterial neurotoxins. ⁵⁴ ⁶¹	Proux-Gillardeaux V...Galli T	18369946	2008
31	An in vitro assay for detection of tetanus neurotoxin activity: using antibodies for recognizing the proteolytically generated cleavage product. ⁶¹ ⁵⁴	Kegel B...Weisser K	17826026	2007
32	Antigen-specific T-cell immunity in multiple myeloma patients is restored following high-dose therapy: implications for timing of vaccination. ⁶¹ ⁵⁴	Svane IM...Johnsen HE	17850592	2007
33	Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response. ⁶¹ ⁵⁴	Stoop JN...van der Molen RG	17654744	2007
34	Effects of intravenous immunoglobulins on peripheral blood mononuclear cell activation in vitro. ⁶¹ ⁵⁴	Sticherling M...Trawinski H	17911484	2007
35	Clinical response to glatiramer acetate correlates with modulation of IFN-gamma and IL-4 expression in multiple sclerosis. ⁶¹ ⁵⁴	Valenzuela RM...Dhib-Jalbut S	17613604	2007
36	What is the function of neuronal AP-3? ⁶¹ ⁵⁴	Danglot L...Galli T	17567262	2007
37	Association between IgG2 and IgG3 subclass responses to toxin A and recurrent Clostridium difficile-associated disease. ⁶¹ ⁵⁴	Katchar K...Kelly CP	17544998	2007
38	Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons. ⁵⁴ ⁶¹	Brito C...Costa J	17335083	2007
39	v-SNARE cellubrevin is required for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells. ⁵⁴ ⁶¹	Fields IC...Folsch H	17485489	2007
40	Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen load. ⁵⁴ ⁶¹	Tilton JC...Connors M	17182676	2007
41	Parental smoking impairs vaccine responses in children with atopic genotypes. ⁶¹ ⁵⁴	Baynam G...LeSouef P	17291854	2007
42	Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. ⁶¹ ⁵⁴	Taira T...Hori T	17691381	2007
43	Distinct functions of neuronal synaptobrevin in developing and mature fly photoreceptors. ⁶¹ ⁵⁴	Rister J...Heisenberg M	16967508	2006
44	Effects of probiotic supplementation for the first 6 months of life on allergen- and vaccine-specific immune responses. ⁶¹ ⁵⁴	Taylor AL...Prescott SL	17014429	2006
45	Bacterial extract (OM-89) specific and non specific immunomodulation in rheumatoid arthritis patients. ⁵⁴ ⁶¹	Toussirot E...Wendling D	16891218	2006
46	Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L. ⁶¹ ⁵⁴	Husain Z...Alper CA	16758339	2006
47	Reduced tetanus antibody titers in overweight children. ⁵⁴ ⁶¹	Eliakim A...Cooper DM	16698670	2006
48	Enhanced viral and tumor immunity with intranodal injection of canary pox viruses expressing the melanoma antigen, gp100. ⁵⁴ ⁶¹	Spaner DE...Berinstein NL	16404742	2006
49	A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity. ⁶¹ ⁵⁴	Lee SE...Rhee JH	16369026	2006
50	Fifteen year experience of intrathecal baclofen treatment in Japan. ⁵⁴ ⁶¹	Taira T...Hori T	17370766	2006

Sources

Genes for Tetanus

Genes related to Tetanus (0 elite genes):

(show all 49)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	42.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)	11068046 10888677 7560075 (more) 18511417 18086678 10196561 8332193 12517971 20297730 9541008 10886393 7713930 17826026 16041714 15469990 11502551 10436029 18543947 16967508 11295657 15327778 11263991 11162495 11020378 10428873 9003771 18650435 9268721 11297538 7836399 9790868
2	VAMP7	Vesicle Associated Membrane Protein 7	Protein Coding	32.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name (show sections)	10811829 17335083 19576189 (more) 9614185 15610906 15813747 14517330 11356871 18819912
3	IFNG	Interferon Gamma	Protein Coding	30.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Drugs & Compounds (show sections)	8120275 9451599 2113474 (more) 7871381 8128858 7561117 8706323 8901428 9469440 10477566 12180110 12296860 12325070 12543104 14768954 14737096 16393321 17182676 1683236 9436462 10856144 7994037 18341617 8094729 9296092 11681488 14965378 15212684 17291854 2119516 7997190 2115511 1972164 11069063 10955927 10600335 9951554 9003208 8757617 18564333 12682236 11799373 10479532 9699087 7729245 8482851 1682270 17850592 16891218 16224278 14980436 10897620 10694982 9394829 7486863 7504995 7902215 1534241 1370514 12580809 12496448 11012627 9227322 7561680 9022014 9166855 9271312 9475303 10963811 11217440 12595759 16157348 16571412 19744828 2253685 1378459
4	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	25.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8195285 8360142 10807583 (more) 10888677 8898098 15466888 15851685 8332193 8549782 11020378 7713930 17485489 15469990 19910495 9003771 9541008 10886393 15777788 15813747 16197886
5	SNAP25	Synaptosome Associated Protein 25	Protein Coding	23.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	7588600 15900706 9013335 (more) 7591680 9295365 15121806 7849517 9886085 11502551 12438157 16150968
6	IL2	Interleukin 2	Protein Coding	22.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8087858 7871381 15577655 (more) 9100988 8312229 7561117 8706323 8901428 9089584 1969449 1715888 17911484 14965378 12738360 8833918 8566072 7688125 8466865 1638764 1805576 1969780 15128839 11897990 9030092 8630108 7994037 7929693 1357123 2253685 15307783 16022583 10897620 10586096 7997190 1673468 2115511 10955927 10896952 15032737 9776473 9759928 9103424 2151598 2315327 8757617 8788122 7973459 7504995 7902215 1534241 1370514 1901422 11527813 11516753 7561680 7797948 2252544 1691692 20224419 20194631 2148638 9278182 12552459 16260902 17182676 1383258 8738963
7	IL4	Interleukin 4	Protein Coding	22.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8103743 8223849 7902215 (more) 8087858 7561117 1474259 8833918 11681488 15212684 7561680 12580809 9451599 9227322 7576707 8120275 12595759 9683547 9271312 9022014 1682270 8647664 17850592 16891218 10897620 10736110 9737657 7997190 1972164 18564333 12641655 9699087 8482851 17613604 14616132 10955927 9003208 8964392 7504995 1534241 1370514 1967279 14965378 9100988 8094729 8706323 12180110 1683236
8	IL10	Interleukin 10	Protein Coding	21.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8499633 8901428 9469440 (more) 12543104 15088299 16393321 9485215 15212684 12595759 20500696 18450120 15128839 9806045 9065029 8647208 1847510 19744828 16758339 10479532 8918588 17654744 10897620 7997190 19300195 15837814 14616132 11304549 10955927 8757617 7902215 10963811 15814696 15949563 16367942 17291854 17014429 20194631
9	CD40LG	CD40 Ligand	Protein Coding	21.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9187781 2357855 8335615 (more) 2258603 1711929 9787318 10484003 11213067 16891224 11251864 16698670 1537371 10904120 16758339
10	NSF	N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase	Protein Coding	19.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10811829 16112083 8360142 (more) 15469990
11	IL5	Interleukin 5	Protein Coding	19.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	7902215 7561117 16393321 (more) 11285124 8833918 15949563 17291854 17014429 9003208 14616132 9271312 10963811 19744828 11012627 15128839 1370514 1534241
12	SNAP23	Synaptosome Associated Protein 23	Protein Coding	19.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19910495 9614185
13	IL13	Interleukin 13	Protein Coding	18.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	14737096 16365410 16393321 (more) 8833918 15949563 17014429 19744828 14616132 18564333
14	CD79A	CD79a Molecule	Protein Coding	17.37	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1532927 8403566 9187781 (more) 20003921 2357855 8562982 9787318 16698670 12499348 12373277 11234492 16369026 11213067 16891224 8477472 7534587 7915975 11251864 9557162 7517378 17544998
15	STX3	Syntaxin 3	Protein Coding	16.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9614185
16	CCR7	C-C Motif Chemokine Receptor 7	Protein Coding	16.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17182676
17	CD27	CD27 Molecule	Protein Coding	15.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17182676
18	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	15.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8374246 18775748 1692058 (more) 9130649 2315327
19	MPP2	Membrane Palmitoylated Protein 2	Protein Coding	14.78	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10886393 18543947 18369946 (more) 11020378
20	LTA	Lymphotoxin Alpha	Protein Coding	14.34	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	2254024
21	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	13.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11436597 17691381 17370766
22	CD80	CD80 Molecule	Protein Coding	13.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	10084309
23	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	13.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12556363
24	IL9	Interleukin 9	Protein Coding	13.22	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	7871381
25	ALB	Albumin	Protein Coding	13.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	TNF	Tumor Necrosis Factor	Protein Coding	13.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
27	IL6	Interleukin 6	Protein Coding	12.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
28	CAV1	Caveolin 1	Protein Coding	12.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19010547 16107720
29	IL1B	Interleukin 1 Beta	Protein Coding	12.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
30	CD247	CD247 Molecule	Protein Coding	12.33	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
31	LBR	Lamin B Receptor	Protein Coding	12.18	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1643425 8223849 11357954 (more) 10744782 15030331 9129267 9877450 9283044 16022583 8198248 18782261 8847089
32	VTI1B	Vesicle Transport Through Interaction With T-SNAREs 1B	Protein Coding	12.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17567262 14973236
33	IL7R	Interleukin 7 Receptor	Protein Coding	12.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
34	NAPA	NSF Attachment Protein Alpha	Protein Coding	12.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
35	CSF2	Colony Stimulating Factor 2	Protein Coding	11.78	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	12641655 14581425
36	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	11.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
37	MBP	Myelin Basic Protein	Protein Coding	11.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7509366 7511974 8690806 (more) 1352532 7686632 9570577 11046067 18292509 9278296 18653385 9683547 10799915 8757617 7486863 15598424 9846813 11150544 12974392
38	CRP	C-Reactive Protein	Protein Coding	11.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
39	CTSE	Cathepsin E	Protein Coding	11.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
40	STX1A	Syntaxin 1A	Protein Coding	11.57	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	16150968
41	MB	Myoglobin	Protein Coding	11.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
42	NEU1	Neuraminidase 1	Protein Coding	11.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	2388710
43	IL1A	Interleukin 1 Alpha	Protein Coding	11.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
44	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	11.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
45	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	11.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
46	FASLG	Fas Ligand	Protein Coding	11.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
47	CTSD	Cathepsin D	Protein Coding	11.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
48	SST	Somatostatin	Protein Coding	11.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
49	IGF1	Insulin Like Growth Factor 1	Protein Coding	10.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Tetanus

Sources

Expression for Tetanus

Search GEO for disease gene expression data for Tetanus.

Sources

Pathways for Tetanus

Pathways related to Tetanus according to GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.99	VAMP3 STX3 SNAP25 SNAP23 LTA IL5
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.84	LTA IL5 IL4 IL2RA IL2 IL13
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.71	LTA IL5 IL4 IL2RA IL2 IL13
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.54	LTA IL5 IL4 IL2RA IL2 IL13
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.46	LTA IL5 IL4 IL2RA IL2 IL13
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.35	STX3 LTA IL5 IL4 IL2RA IL2
7	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.31	LTA IL5 IL4 IL2RA IL2 IL13
8	Pathways in cancer ³⁶	12.86	IL5 IL4 IL2RA IL2 IL13 IFNG
9	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.83	LTA IL5 IL4 IL2RA IL2 IL13
10	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.7	IL4 IL2RA IL2 IL10 IFNG CD79A
11	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.65	IL5 IL4 IL2 IL10 IFNG CD40LG
12	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.65	IL5 IL4 IL2RA IL2 IL13 IL10
13	NF-kappaB Signaling ⁴	12.59	IL4 IL2RA IL2 IL10 IFNG CD79A
14	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.52	IL5 IL4 IL2RA IL2 IL13 IL10
15	Delta508-CFTR traffic / ER-to-Golgi in CF ²² Show member pathways Normal wtCFTR traffic / ER-to-Golgi ²² RHO GTPases regulate CFTR trafficking ⁶⁵ Transport Clathrin-coated vesicle cycle ²² wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF) ²² wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) ²²	12.47	VAMP7 VAMP2 SNAP25 SNAP23 NSF
16	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.43	IL5 IL2RA IL2 IL13
17	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.37	LTA IL2RA IL2 IL10 CCR7
18	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.33	IL5 IL4 IL13 IFNG
19	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.27	LTA IL5 IL4 IL2RA IL2 IL13
20	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.26	IL4 IL10 IFNG CD40LG
21	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.19	VAMP2 SNAP25 IL13 IL10
22	Jak Stat Signaling Pathway ⁶⁶ Show member pathways Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	12.1	IL4 IL2RA IL2
23	Synaptic vesicle cycle ³⁶ Show member pathways Synaptic Vesicle Pathway ¹	12.08	VAMP2 STX3 SNAP25 NSF
24	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	12.06	IL5 IL2RA IL2 IL13
25	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.01	IL4 IL2RA IL2 IFNG
26	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	11.97	LTA IL2 IL10 IFNG
27	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics ⁶⁰ Show member pathways Nicotine Activity on Dopaminergic Neurons ¹ SNARE interactions in vesicular transport ³⁶	11.96	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23
28	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.92	IL5 IL4 IL2RA IL2 IL10 IFNG
29	Glucocorticoid receptor regulatory network ¹	11.87	IL5 IL4 IL2 IL13 IFNG
30	Th17 Differentiation ⁶⁴ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.85	IL4 IFNG CCR7
31	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.8	LTA CD40LG CD27
32	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.76	LTA IL4 IL2RA IL2
33	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.76	IL5 IL4 IL2RA IL2 IFNG CD40LG
34	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.75	IL2 IL10 IFNG
35	IL4-mediated signaling events ¹	11.71	LTA IL5 IL4 IL10 CD40LG
36	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.67	IL2 IFNG CD40LG
37	Lung fibrosis ¹	11.67	IL5 IL4 IL13
38	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.65	IL2RA IL2 IFNG
39	Malaria ³⁶	11.56	IL10 IFNG CD40LG
40	Interleukin-10 signaling ⁶⁵	11.55	IL4 IL13 IL10
41	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.46	IL2RA IL2 IL10 IFNG
42	Innate Lymphoid Cells Differentiation ⁶⁴	11.46	LTA IL5 IL4 IL2RA IL2 IL13
43	Delta508-CFTR traffic / Sorting endosome formation in CF ²² Show member pathways Normal wtCFTR traffic / Sorting endosome formation ²²	11.44	VAMP2 SNAP25 NSF
44	Development and heterogeneity of the ILC family ¹	11.4	IL5 IL4 IL13 IFNG
45	Inflammatory Response Pathway ¹	11.36	IL5 IL4 IL2RA IL2 IFNG CD40LG
46	Th2 Differentiation ⁶⁴	11.36	IL5 IL4 IL2RA IL2 IL13 IL10
47	IL12 signaling mediated by STAT4 ¹	11.33	IL2RA IL2 IL13 IFNG
48	Cytokines and Inflammatory Response ¹	11.26	IL5 IL4 IL2 IL13 IL10 IFNG
49	G-protein signaling_Rap2B regulation pathway ²²	11.07	LTA IL5 IL4 IL2 IL13 IL10
50	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	10.87	IL5 IL4 IL13

Sources

GO Terms for Tetanus

Cellular components related to Tetanus according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.25	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23
2	extracellular region	GO:0005576	10.18	LTA IL5 IL4 IL2 IL13 IL10
3	extracellular space	GO:0005615	10.15	LTA IL5 IL4 IL2 IL13 IL10
4	cell junction	GO:0030054	10.01	VAMP7 VAMP3 VAMP2 SNAP25 SNAP23 MPP2
5	synapse	GO:0045202	9.93	VAMP7 VAMP3 VAMP2 SNAP25 SNAP23 MPP2
6	cell surface	GO:0009986	9.85	VAMP7 VAMP3 IL2RA CD40LG CD27 CCR7
7	phagocytic vesicle membrane	GO:0030670	9.65	VAMP7 VAMP3 SNAP23
8	neuron projection	GO:0043005	9.63	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23
9	clathrin-coated vesicle membrane	GO:0030665	9.58	VAMP7 VAMP3 VAMP2
10	specific granule	GO:0042581	9.56	STX3 SNAP23
11	secretory granule	GO:0030141	9.56	VAMP7 VAMP3 VAMP2 STX3
12	zymogen granule membrane	GO:0042589	9.51	VAMP2 STX3
13	azurophil granule	GO:0042582	9.49	STX3 SNAP23
14	external side of plasma membrane	GO:0009897	9.43	IL2RA IL13 CD79A CD40LG CD27 CCR7
15	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	GO:0070032	9.32	VAMP2 SNAP25
16	SNARE complex	GO:0031201	9.1	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23

Biological processes related to Tetanus according to GeneCards Suite gene sharing:

(show all 50)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	10.11	STX3 IL5 IL4 IL2 IFNG
2	negative regulation of apoptotic process	GO:0043066	10.1	IL4 IL2 IL10 CD40LG CD27
3	inflammatory response	GO:0006954	10.08	IL5 IL2RA IL13 CD40LG CCR7
4	vesicle-mediated transport	GO:0016192	10.01	VAMP7 VAMP3 VAMP2 STX3 NSF
5	response to lipopolysaccharide	GO:0032496	9.97	LTA IL13 IL10 CCR7
6	B cell differentiation	GO:0030183	9.88	IL4 IL10 CD79A CD40LG
7	negative regulation of inflammatory response	GO:0050728	9.88	IL4 IL2RA IL2 IL13 IL10
8	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.87	IL4 IL2 IL13 IFNG
9	positive regulation of T cell proliferation	GO:0042102	9.85	IL4 IL2RA IL2 CD40LG
10	negative regulation of endothelial cell apoptotic process	GO:2000352	9.81	IL4 IL13 IL10
11	B cell proliferation	GO:0042100	9.81	IL10 CD79A CD40LG
12	cytokine-mediated signaling pathway	GO:0019221	9.8	STX3 IL5 IL4 IL2RA IL2 IL13
13	calcium ion regulated exocytosis	GO:0017156	9.78	VAMP7 VAMP3 VAMP2
14	microglial cell activation	GO:0001774	9.77	IL4 IL13 IFNG
15	positive regulation of interleukin-12 production	GO:0032735	9.77	IFNG CD40LG CCR7
16	post-Golgi vesicle-mediated transport	GO:0006892	9.76	VAMP7 VAMP2 SNAP23
17	long-term synaptic potentiation	GO:0060291	9.76	VAMP2 STX3 SNAP25 MPP2
18	regulation of regulatory T cell differentiation	GO:0045589	9.73	IL2RA IL2 IFNG
19	membrane fusion	GO:0061025	9.73	VAMP3 VAMP2 STX3 SNAP23
20	synaptic vesicle fusion to presynaptic active zone membrane	GO:0031629	9.71	STX3 SNAP25 SNAP23
21	positive regulation of B cell proliferation	GO:0030890	9.71	IL5 IL4 IL2 IL13
22	positive regulation of chemokine biosynthetic process	GO:0045080	9.7	IL4 IFNG
23	macrophage activation	GO:0042116	9.7	IL4 IL13
24	positive regulation of interleukin-10 secretion	GO:2001181	9.7	IL4 IL13
25	positive regulation of mast cell degranulation	GO:0043306	9.7	IL4 IL13
26	positive regulation of immunoglobulin secretion	GO:0051024	9.7	VAMP3 IL5 IL2
27	exocytosis	GO:0006887	9.7	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23
28	negative regulation of tumor necrosis factor biosynthetic process	GO:0042536	9.69	IL4 IL10
29	interleukin-2-mediated signaling pathway	GO:0038110	9.69	IL2RA IL2
30	synaptic vesicle docking	GO:0016081	9.69	STX3 SNAP25
31	SNARE complex assembly	GO:0035493	9.69	VAMP7 VAMP3 VAMP2
32	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.68	IL4 IL2
33	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.68	IL4 IL2
34	negative regulation of lymphocyte proliferation	GO:0050672	9.68	IL2RA IL2
35	natural killer cell degranulation	GO:0043320	9.67	VAMP7 VAMP2
36	type 2 immune response	GO:0042092	9.67	IL4 IL10
37	positive regulation of MHC class II biosynthetic process	GO:0045348	9.67	IL4 IL10 IFNG
38	Golgi to plasma membrane protein transport	GO:0043001	9.67	VAMP7 VAMP3 VAMP2 NSF
39	positive regulation of cellular respiration	GO:1901857	9.66	IL4 IFNG
40	neuroinflammatory response	GO:0150076	9.66	IL4 IFNG
41	exocytic insertion of neurotransmitter receptor to postsynaptic membrane	GO:0098967	9.65	STX3 SNAP25
42	mucus secretion	GO:0070254	9.65	VAMP3 VAMP2
43	regulation of isotype switching	GO:0045191	9.65	IL4 IL10
44	immune response	GO:0006955	9.65	LTA IL5 IL4 IL2RA IL2 IL13
45	eosinophil degranulation	GO:0043308	9.64	VAMP7 VAMP2
46	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.63	IL4 IL13
47	regulation of histamine secretion by mast cell	GO:1903593	9.62	VAMP3 VAMP2
48	regulation of T cell homeostatic proliferation	GO:0046013	9.62	IL2RA IL2
49	positive regulation of T cell differentiation	GO:0045582	9.62	IL4 IL2RA IL2 CD27
50	vesicle fusion	GO:0006906	9.1	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23

Molecular functions related to Tetanus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.35	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23
2	SNARE binding	GO:0000149	9.73	VAMP7 VAMP3 VAMP2 STX3 SNAP25 NSF
3	growth factor activity	GO:0008083	9.71	IL5 IL4 IL2 IL10
4	syntaxin binding	GO:0019905	9.63	VAMP7 VAMP3 VAMP2 SNAP25 SNAP23 NSF
5	syntaxin-1 binding	GO:0017075	9.62	VAMP3 VAMP2 SNAP25 NSF
6	cytokine activity	GO:0005125	9.56	LTA IL5 IL4 IL2 IL13 IL10
7	SNAP receptor activity	GO:0005484	9.1	VAMP7 VAMP3 VAMP2 STX3 SNAP25 SNAP23

Sources

Sources for Tetanus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Tetanus

Aliases & Classifications for Tetanus

MalaCards integrated aliases for Tetanus:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Tetanus

Related Diseases for Tetanus

Diseases related to Tetanus via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Tetanus:

Symptoms & Phenotypes for Tetanus

Human phenotypes related to Tetanus:

UMLS symptoms related to Tetanus:

GenomeRNAi Phenotypes related to Tetanus according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Tetanus:

Drugs & Therapeutics for Tetanus

Drugs for Tetanus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: tetanus

Genetic Tests for Tetanus

Anatomical Context for Tetanus

MalaCards organs/tissues related to Tetanus:

Publications for Tetanus

Articles related to Tetanus:

Genes for Tetanus

Genes related to Tetanus (0 elite genes):

Variations for Tetanus

Expression for Tetanus

Pathways for Tetanus

Pathways related to Tetanus according to GeneCards Suite gene sharing:

GO Terms for Tetanus

Cellular components related to Tetanus according to GeneCards Suite gene sharing:

Biological processes related to Tetanus according to GeneCards Suite gene sharing:

Molecular functions related to Tetanus according to GeneCards Suite gene sharing:

Sources for Tetanus

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :