NNT
MCID: TTN001
MIFTS: 32

Tetanus Neonatorum (NNT)

Categories: Infectious diseases

Aliases & Classifications for Tetanus Neonatorum

MalaCards integrated aliases for Tetanus Neonatorum:

Name: Tetanus Neonatorum 12 15 71 32
Neonatal Tetanus 12
Nnt 48

Classifications:



External Ids:

Disease Ontology 12 DOID:13521
ICD9CM 34 771.3
NCIt 50 C116814
SNOMED-CT 67 43424001
ICD10 32 A33
UMLS 71 C0343312

Summaries for Tetanus Neonatorum

Disease Ontology : 12 A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has symptom stiff body, has symptom muscle spasms, has symptom difficulty in breathing, and has symptom exhaustion.

MalaCards based summary : Tetanus Neonatorum, also known as neonatal tetanus, is related to familial glucocorticoid deficiency and tetanus. An important gene associated with Tetanus Neonatorum is SLC4A1 (Solute Carrier Family 4 Member 1 (Diego Blood Group)), and among its related pathways/superpathways are Pyruvate metabolism and Glyoxylate and dicarboxylate metabolism. The drugs Antitoxins and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin and brain, and related phenotype is mortality/aging.

Related Diseases for Tetanus Neonatorum

Diseases related to Tetanus Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 familial glucocorticoid deficiency 11.4
2 tetanus 11.2
3 cervical cancer 11.1
4 hepatocellular carcinoma 11.1
5 glucocorticoid deficiency 4 with or without mineralocorticoid deficiency 11.1
6 colorectal cancer 11.1
7 glucose intolerance 11.1
8 osteogenic sarcoma 11.0
9 ovarian cancer 11.0
10 left ventricular noncompaction 11.0
11 breast cancer 11.0
12 achalasia-addisonianism-alacrima syndrome 10.9
13 microcephaly 1, primary, autosomal recessive 10.9
14 retinitis pigmentosa 22 10.9
15 seckel syndrome 5 10.9
16 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.9
17 poliomyelitis 10.3
18 diphtheria 10.3
19 pertussis 10.1
20 measles 10.1
21 otitis media 10.1
22 cyanosis, transient neonatal 10.1
23 keratomalacia 10.1
24 spasticity 10.1
25 lung cancer 10.0
26 gastric cancer 10.0
27 cholangiocarcinoma 10.0
28 intrahepatic cholangiocarcinoma 10.0
29 maple syrup urine disease 10.0
30 aspiration pneumonia 10.0
31 bronchopneumonia 10.0
32 quadriplegia 10.0
33 kwashiorkor 10.0
34 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
35 crisponi/cold-induced sweating syndrome 1 10.0
36 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
37 disease by infectious agent 10.0
38 cold-induced sweating syndrome 10.0
39 respiratory failure 10.0
40 cholera 10.0
41 cold-induced sweating syndrome including crisponi syndrome 10.0
42 autonomic dysfunction 10.0
43 hypertonia 10.0
44 bladder cancer 9.9
45 small cell cancer of the lung 9.9
46 branchiootic syndrome 1 9.8
47 paralytic poliomyelitis 9.8
48 autosomal recessive disease 9.8
49 yaws 9.8
50 microcephaly 9.8

Graphical network of the top 20 diseases related to Tetanus Neonatorum:



Diseases related to Tetanus Neonatorum

Symptoms & Phenotypes for Tetanus Neonatorum

MGI Mouse Phenotypes related to Tetanus Neonatorum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 CENPJ CRLF1 FCGRT MDH1 MDH2 OXT

Drugs & Therapeutics for Tetanus Neonatorum

Drugs for Tetanus Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antitoxins
2 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Study of Tetanus Patients in Fujian Province of China Completed NCT04165928

Search NIH Clinical Center for Tetanus Neonatorum

Genetic Tests for Tetanus Neonatorum

Anatomical Context for Tetanus Neonatorum

MalaCards organs/tissues related to Tetanus Neonatorum:

40
Skin, Brain

Publications for Tetanus Neonatorum

Articles related to Tetanus Neonatorum:

(show top 50) (show all 877)
# Title Authors PMID Year
1
Effects of immunization program on morbidity and mortality rates ofvaccine-preventable diseases in Turkey 61
33128356 2020
2
Vaccination in the Philippines: experiences from history and lessons for the future. 61
33357156 2020
3
Neonatal tetanus in St. Mary's Hospital Lacor: A case report. 61
33235766 2020
4
The association between area of residence and sufficient antenatal tetanus vaccination in women ages 15-49 in Afghanistan: an analysis of the 2015 DHS dataset. 61
33292868 2020
5
Seroprevalence of Measles, Rubella, Tetanus, and Diphtheria Antibodies among Children in Haiti, 2017. 61
32618256 2020
6
Provincial-level outcomes of China's 'Reducing maternal mortality and eliminating neonatal tetanus' program. 61
32770045 2020
7
Knowledge and health beliefs of reproductive-age women in Alexandria about tetanus toxoid immunization. 61
32852679 2020
8
Antenatal care service delivery and factors affecting effective tetanus vaccine coverage in low- and middle-income countries: Results of the Maternal Immunisation and Antenatal Care Situational analysis (MIACSA) project. 61
32527598 2020
9
Neonatal Tetanus in a Nomadic Population in South India: A Clinicosocial Case Study. 61
33354027 2020
10
Increasing Frequency of Antenatal Care Visits May Improve Tetanus Toxoid Vaccination Coverage in Pregnant Women in Pakistan. 61
32118509 2020
11
50 Years Ago in TheJournalofPediatrics: Convulsion Score for Neonatal Tetanus: An Obituary! 61
32446496 2020
12
Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status. 61
32482459 2020
13
Progress Toward Maternal and Neonatal Tetanus Elimination - Worldwide, 2000-2018. 61
32352953 2020
14
Effect of cash incentives on tetanus toxoid vaccination among rural Nigerian women: a randomized controlled trial. 61
31567041 2020
15
The Prevalence and Case-Fatality Rates of Post-Neonatal Tetanus in a Population of Hospitalized Nigerian Children: An 8-Year Retrospective Review. 61
31397484 2020
16
[Immunization to prevent non-neonatal tetanus]. 61
32135606 2020
17
An investment case for maternal and neonatal tetanus elimination. 61
31980197 2020
18
[Specifications for diagnosis and treatment of non-neonatal tetanus]. 61
32164123 2020
19
[Guidelines for the use of post-traumatic tetanus vaccines and passive immune preparation]. 61
32164124 2020
20
[Research progress of tetanus antibody detection technology in China]. 61
32074715 2020
21
Multicenter Study of Tetanus Patients in Fujian Province of China: A Retrospective Review of 95 Cases. 61
32258151 2020
22
Determinants of births protected against neonatal tetanus in Ethiopia: A multilevel analysis using EDHS 2016 data. 61
33259554 2020
23
Tetanus Toxoid Vaccination Uptake and Associated Factors among Mothers Who Gave Birth in the Last 12 Months in Errer District, Somali Regional State, Eastern Ethiopia. 61
32461983 2020
24
Diagnosis and Management of Cryptogenic Occupational Tetanus: A Case Report from Rajasthan, India. 61
32435114 2020
25
Seroprevalence of anti-tetanus antibodies in mothers and cord blood and associated factors in health-care settings in Lao People's Democratic Republic. 61
31735506 2020
26
Neonatal tetanus in eastern Uganda: improved outcome following the implementation of a neonatal tetanus protocol. 61
31474192 2020
27
Demography and Symptom Profile of Tetanus: A Cross-sectional Observation in an Infectious Disease Hospital of Bangladesh. 61
31915348 2020
28
Effectiveness of birthing kits for clean childbirth: a systematic review. 61
31340003 2020
29
New immunization strategies: adapting to global challenges. 61
31802153 2020
30
Collective memory of umbilical cord stump care: an educational experience. 61
31851274 2019
31
[Dramatic achievements in infectious disease prevention and treatment in China during the past 70 years]. 61
32062906 2019
32
[Specifications for diagnosis and treatment of non-neonatal tetanus]. 61
31795576 2019
33
[Guidelines for the use of post-traumatic tetanus vaccines and passive immune preparation]. 61
31795577 2019
34
[Improving immunization strategy and promoting the development of tetanus prevention and control in China]. 61
31795575 2019
35
Use of Social Mobilization and Community Mobilizers by Non-governmental Health Organizations in Malawi to Support the Eradication of Polio, Improve Routine Immunization Coverage, and Control Measles and Neonatal Tetanus. 61
31760969 2019
36
The CORE Group Polio Project's Community Volunteers and Polio Eradication in Ethiopia: Self-Reports of Their Activities, Knowledge, and Contributions. 61
31760977 2019
37
Prognostic factors and outcome of Post-Neonatal Tetanus in an intensive care unit of a Tertiary Care Hospital. 61
31488984 2019
38
Knowledge about and preventive practices against neonatal tetanus among young Nigerian women. 61
31258290 2019
39
SERUM TOTAL IgG AND TETANUS SPECIFIC IgG IN NIGERIAN HUMAN IMMUNODEFICIENCY VIRUS INFECTED PRIMIGRAVIDAE AND THE CORD BLOOD OF THEIR BABIES AT BIRTH. 61
31768150 2019
40
Maternal Immunization and Antenatal Care Situation Analysis (MIACSA) study protocol: a multiregional, cross-sectional analysis of maternal immunization delivery strategies to reduce maternal and neonatal morbidity and mortality. 61
31167857 2019
41
Immunization in Vietnam. 61
31069373 2019
42
Maternal immunization: A call to accelerate progress. 61
31014962 2019
43
Key considerations for successful implementation of maternal immunization programs in low and middle income countries. 61
30676250 2019
44
Tetanus in Poland in 2017 61
31385677 2019
45
Eliminating Maternal and Neonatal Tetanus and Promoting Clean Delivery Practices Through Disposable Clean Birth Kits. 61
31824909 2019
46
A Rare Case of Localized Tetanus. 61
30294137 2018
47
Effects of a community-based data for decision-making intervention on maternal and newborn health care practices in Ethiopia: a dose-response study. 61
30255793 2018
48
The crucial role of maternal care providers as vaccinators for pregnant women. 61
28822646 2018
49
Maternal and Neonatal Tetanus Elimination (MNTE) in The WHO African Region. 61
30882092 2018
50
Pre-post effects of a tetanus care protocol implementation in a sub-Saharan African intensive care unit. 61
30161119 2018

Variations for Tetanus Neonatorum

Expression for Tetanus Neonatorum

Search GEO for disease gene expression data for Tetanus Neonatorum.

Pathways for Tetanus Neonatorum

Pathways related to Tetanus Neonatorum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.58 MDH2 MDH1
2 10.1 MDH2 MDH1

GO Terms for Tetanus Neonatorum

Biological processes related to Tetanus Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.4 MDH2 MDH1
2 tricarboxylic acid cycle GO:0006099 9.37 MDH2 MDH1
3 carboxylic acid metabolic process GO:0019752 9.32 MDH2 MDH1
4 NADH metabolic process GO:0006734 9.26 MDH2 MDH1
5 oxaloacetate metabolic process GO:0006107 9.16 MDH2 MDH1
6 malate metabolic process GO:0006108 8.96 MDH2 MDH1
7 negative regulation of urine volume GO:0035811 8.62 SLC4A1 OXT

Molecular functions related to Tetanus Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 MDH2 MDH1
2 L-malate dehydrogenase activity GO:0030060 8.96 MDH2 MDH1
3 malate dehydrogenase activity GO:0016615 8.62 MDH2 MDH1

Sources for Tetanus Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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