MCID: TTH021
MIFTS: 28

Tethered Cord Syndrome

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tethered Cord Syndrome

MalaCards integrated aliases for Tethered Cord Syndrome:

Name: Tethered Cord Syndrome 53 72
Occult Spinal Dysraphism Sequence 53
Tethered Spinal Cord Syndrome 53
Segmental Vertebral Anomalies 53
Occult Spinal Dysraphism 53
Tethered Cord 6

Classifications:



External Ids:

UMLS 72 C0080218

Summaries for Tethered Cord Syndrome

NIH Rare Diseases : 53 Tethered cord syndrome is a rare neurological condition. The severity of the condition and the associated signs and symptoms vary from person to person. In some cases, symptoms may be present at birth (congenital), while others may not experience symptoms until later in adulthood. Features of the condition may include foot and spinal abnormalities; weakness in the legs; loss of sensation (feeling) in the lower limbs; lower back pain; scoliosis; and urinary incontinence. Infants and children with congenital tethered cord syndrome may also have tufts of hair, dimples, skin discoloration, or benign fatty tumors on the lower back. Tethered cord syndrome occurs when tissue attachments limit the movement of the spinal cord within the spinal column. In some cases, it may be the result of improper growth of the neural tube during fetal development, which is closely linked to spina bifida. Other potential causes include narrowing of the spinal column (with age), spinal cord injury, tumors, and infection. Treatment varies based on the signs and symptoms present in each person and the severity of the condition but may include surgery and medications to manage pain.

MalaCards based summary : Tethered Cord Syndrome, also known as occult spinal dysraphism sequence, is related to primary tethered cord syndrome and tethered spinal cord syndrome. An important gene associated with Tethered Cord Syndrome is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase). The drug Dermatologic Agents has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and tonsil.

Related Diseases for Tethered Cord Syndrome

Diseases in the Tethered Cord Syndrome family:

Primary Tethered Cord Syndrome

Diseases related to Tethered Cord Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 primary tethered cord syndrome 12.6
2 tethered spinal cord syndrome 11.7
3 lipomatosis, multiple 10.7
4 pleomorphic lipoma 10.7
5 myelomeningocele 10.7
6 neural tube defects 10.7
7 lipomyelomeningocele 10.6
8 scoliosis 10.5
9 diastematomyelia 10.5
10 meningocele 10.5
11 neurogenic bladder 10.5
12 split spinal cord malformation 10.5
13 syringomyelia, noncommunicating isolated 10.5
14 spina bifida occulta 10.5
15 syringomyelia 10.5
16 back pain 10.4
17 anorectal anomalies 10.4
18 lumbosacral lipoma 10.4
19 rare surgical neurologic disease 10.4
20 47,xyy 10.3
21 hydrocephalus 10.3
22 congenital hydrocephalus 10.3
23 spasticity 10.3
24 spinal cord injury 10.3
25 immunodeficiency, common variable, 10 10.3
26 muscular atrophy 10.2
27 chiari malformation 10.2
28 paraplegia 10.2
29 syringohydromyelia 10.2
30 constipation 10.2
31 hypertrichosis 10.2
32 neurenteric cyst 10.2
33 spina bifida aperta 10.2
34 paresthesia 10.1
35 tracheoesophageal fistula with or without esophageal atresia 10.0
36 renal hypodysplasia/aplasia 1 10.0
37 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
38 oeis complex 10.0
39 wilms tumor 5 10.0
40 anxiety 10.0
41 spondylocostal dysostosis 3, autosomal recessive 10.0
42 inguinal hernia 10.0
43 omphalocele 10.0
44 cloacal exstrophy 10.0
45 esophageal atresia 10.0
46 telangiectasis 10.0
47 dysostosis 10.0
48 capillary hemangioma 10.0
49 spinal cord disease 10.0
50 mast cell neoplasm 10.0

Graphical network of the top 20 diseases related to Tethered Cord Syndrome:



Diseases related to Tethered Cord Syndrome

Symptoms & Phenotypes for Tethered Cord Syndrome

Drugs & Therapeutics for Tethered Cord Syndrome

Drugs for Tethered Cord Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dermatologic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetics of Neural Tubes Defects Unknown status NCT01253746
2 Hemangioma Associated With High Rates of Morbidity:A Prospective Study Completed NCT00394888
3 Treatment of Persistent Urinary Incontinence in Children Completed NCT00124046
4 Characterization of At-risk Population and Prognosis Factors for SACRO-coccygeal Teratoma in CURRARINO Syndrome. A Clinical, Molecular and Pathological Study. Completed NCT00780117
5 Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome: A Conservative Treatment- Controlled, Randomized, Clinical Study Recruiting NCT03262844
6 Magnetic Resonance Imaging of the Spine Withdrawn NCT01382290

Search NIH Clinical Center for Tethered Cord Syndrome

Genetic Tests for Tethered Cord Syndrome

Anatomical Context for Tethered Cord Syndrome

MalaCards organs/tissues related to Tethered Cord Syndrome:

41
Spinal Cord, Skin, Tonsil, Brain, Colon, Prostate, Uterus

Publications for Tethered Cord Syndrome

Articles related to Tethered Cord Syndrome:

(show top 50) (show all 612)
# Title Authors PMID Year
1
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Incidence of Tethered Cord Syndrome in Infants With Myelomeningocele With Prenatal Versus Postnatal Repair. 38
31418037 2019
2
Meningocele Manqué Discovered During Filum Terminale Resection in Occult Tethered Cord Syndrome. 38
31430540 2019
3
Tethered Cord Syndrome. 38
31404355 2019
4
Tethered cord syndrome with lower back pain and lumbosacral angle increase: case report. 38
31410565 2019
5
Republished: Transradial approach in the treatment of a sacral dural arteriovenous fistula: a technical note. 38
31118268 2019
6
Clinical observations on the release of tethered spinal cord in children with intra-operative neurophysiological monitoring: A retrospective study. 38
31421991 2019
7
Homogeneous Spinal-Shortening Axial Decompression for Tethered Cord Syndrome: Modified Spinal Column Shortening. 38
30928585 2019
8
Assessing Spinal Cord Injury Area in Patients with Tethered Cord Syndrome by Diffusion Tensor Imaging. 38
30928592 2019
9
Clubfoot and Tethered Cord Syndrome: Results of Treatment With the Ponseti Method. 38
31169753 2019
10
Towards Guideline-Based Management of Tethered Cord Syndrome in Spina Bifida: A Global Health Paradigm Shift in the Era of Prenatal Surgery. 38
31284336 2019
11
Spinal Column Shortening for Secondary Tethered Cord Syndrome in Children: 2-Dimensional Operative Video. 38
30169877 2019
12
Surgical treatment of tethered cord syndrome-comparing the results of surgeries with and without electrophysiological monitoring. 38
30963241 2019
13
Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Study. 38
31086097 2019
14
Minimally Invasive Tubular Tethered Cord Release in the Pediatric Population. 38
31096033 2019
15
Tethered Cord Syndrome-Role of Early Surgery. 38
31105399 2019
16
[Dissociation of Anatomical (Neurological) Diagnosis and Imaging Diagnosis]. 38
30827958 2019
17
The Use of Prone Magnetic Resonance Imaging to Rule Out Tethered Cord in Patients With Structural Spine Anomalies: A Diagnostic Technical Note for Surgical Decision-making. 38
31123643 2019
18
Transradial approach in the treatment of a sacral dural arteriovenous fistula: a technical note. 38
30936323 2019
19
Secondary sacral tethered cord syndrome after treatment of secondary cervical syringomyelia. 38
30470654 2019
20
Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels. 38
30758868 2019
21
Dermoid sinus type VI associated with spina bifida and tethered cord syndrome in a French Bulldog. 38
30734666 2019
22
Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery. 38
30280214 2019
23
Ventral and dorsal tethering bands of the spinal cord in the same patient: a case report. 38
30338360 2019
24
Spinal Cord Stimulation in Adult Tethered Cord Syndrome: Case Report and Review of the Literature. 38
30415046 2019
25
Prof. Shokei Yamada: An International Neurosurgeon, Regarded as Father Figure for Adult Tethered Cord Syndrome Management and Dedicated Life for the Advancement of Intracranial Arteriovenous Malformation Surgery. 38
30937074 2019
26
Homogeneous Spinal-Shortening Axial Decompression as a Revision Surgery After Untethering Surgery in Pediatric Patients with Tethered Cord Syndrome. 38
30660897 2019
27
Limited Dorsal Myeloschisis with and without Type I Split Cord Malformation: Report of 3 Cases and Surgical Nuances. 38
30691191 2019
28
Chiari Malformations. 38
30610307 2019
29
Importance of Physical Examination and Imaging in the Detection of Tethered Cord Syndrome. 38
31218244 2019
30
Dynamic magnetic resonance imaging parameters for objective assessment of the magnitude of tethered cord syndrome in patients with spinal dysraphism. 38
30456429 2019
31
Elongated conus medullaris, sacral agenesis and scoliosis- a case report of a patient with trisomy 19q and monosomy 7q. 38
30641238 2019
32
Microsurgical efficacy in 326 children with tethered cord syndrome: a retrospective analysis. 38
30531089 2019
33
Chiari malformation clusters describe differing presence of concurrent anomalies based on Chiari type. 38
30279122 2018
34
Tethered Cord and Anorectal Malformations: A Case Series. 38
28946162 2018
35
Using subdural strip electrodes to define functional sensory nerves and the most inferior functional portion of the conus medullaris during detethering surgeries for tethered cord syndrome: a pilot study. 38
30004314 2018
36
Type 1 Split Cord Malformation: The Significance of the 3D Orientation of the Bony Spur, Its Clinical Relevance, and Surgical Nuances. 38
30937084 2018
37
Mechanical relationship of filum terminale externum and filum terminale internum: is it possible to detether the spinal cord extradurally? 38
29797063 2018
38
Clinical Outcomes of Primary and Revision Untethering Surgery in Patients with Tethered Cord Syndrome and Spinal Bifida. 38
29649647 2018
39
Efficacy of Anal Needle Electrodes for Intraoperative Spinal Cord Monitoring with Transcranial Muscle Action Potentials. 38
30060374 2018
40
Relationship of Morphologic Changes in the Brain and Spinal Cord and Disease Symptoms with Cerebrospinal Fluid Hydrodynamic Changes in Patients with Chiari Malformation Type I. 38
29803060 2018
41
Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele. 38
29678699 2018
42
Transhiatal Approach to Filum Terminale Externum Sectioning in Adult Patient With Tethered Cord Syndrome: Case Report. 38
28961973 2018
43
Clinical evaluation of an innovative operative procedure in the treatment of the tethered cord syndrome. 38
29055742 2018
44
Multiple neurosurgical treatments for different members of the same family with Currarino syndrome. 38
29731315 2018
45
Surgical Outcomes of Pediatric Patients with Asymptomatic Tethered Cord Syndrome. 38
29879784 2018
46
Tailored Strategies to Manage Cerebrospinal Fluid Leaks or Pseudomeningocele After Surgery for Tethered Cord Syndrome. 38
29605699 2018
47
Spine-shortening osteotomy for patients with tethered cord syndrome: a systematic review and meta-analysis. 38
29528274 2018
48
Thoracolumbar spinal neurenteric cyst with tethered cord syndrome and extreme cervical lordosis in a child: A case report and literature review. 38
29668630 2018
49
Adult Versus Pediatric Tethered Cord Syndrome: Clinicoradiological Differences and its Management. 38
29682019 2018
50
Adult Tethered Cord Syndrome Following Chiari Decompression. 38
29409774 2018

Variations for Tethered Cord Syndrome

ClinVar genetic disease variations for Tethered Cord Syndrome:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 BRAF NM_004333.6(BRAF): c.1600G> C (p.Gly534Arg) single nucleotide variant Pathogenic/Likely pathogenic rs180177041 7:140476806-140476806 7:140777006-140777006

Expression for Tethered Cord Syndrome

Search GEO for disease gene expression data for Tethered Cord Syndrome.

Pathways for Tethered Cord Syndrome

GO Terms for Tethered Cord Syndrome

Sources for Tethered Cord Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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