MCID: TTH021
MIFTS: 27

Tethered Cord Syndrome

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tethered Cord Syndrome

MalaCards integrated aliases for Tethered Cord Syndrome:

Name: Tethered Cord Syndrome 54 74
Occult Spinal Dysraphism Sequence 54
Tethered Spinal Cord Syndrome 54
Segmental Vertebral Anomalies 54
Occult Spinal Dysraphism 54

Classifications:



External Ids:

UMLS 74 C0080218

Summaries for Tethered Cord Syndrome

NIH Rare Diseases : 54 Tethered cord syndrome is a rare neurological condition. The severity of the condition and the associated signs and symptoms vary from person to person. In some cases, symptoms may be present at birth (congenital), while others may not experience symptoms until later in adulthood. Features of the condition may include foot and spinal abnormalities; weakness in the legs; loss of sensation (feeling) in the lower limbs; lower back pain; scoliosis; and urinary incontinence. Infants and children with congenital tethered cord syndrome may also have tufts of hair, dimples, skin discoloration, or benign fatty tumors on the lower back. Tethered cord syndrome occurs when tissue attachments limit the movement of the spinal cord within the spinal column. In some cases, it may be the result of improper growth of the neural tube during fetal development, which is closely linked to spina bifida. Other potential causes include narrowing of the spinal column (with age), spinal cord injury, tumors, and infection. Treatment varies based on the signs and symptoms present in each person and the severity of the condition but may include surgery and medications to manage pain.

MalaCards based summary : Tethered Cord Syndrome, also known as occult spinal dysraphism sequence, is related to primary tethered cord syndrome and tethered spinal cord syndrome. The drugs Acetazolamide and Natriuretic Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and testes.

Related Diseases for Tethered Cord Syndrome

Diseases in the Tethered Cord Syndrome family:

Primary Tethered Cord Syndrome

Diseases related to Tethered Cord Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 primary tethered cord syndrome 12.5
2 tethered spinal cord syndrome 11.6
3 neural tube defects 10.4
4 myelomeningocele 10.4
5 syringomyelia 10.3
6 lipomyelomeningocele 10.2
7 scoliosis 10.1
8 neurenteric cyst 10.1
9 spina bifida aperta 10.1
10 lipomatosis, multiple 10.0
11 spinal cord injury 10.0
12 spina bifida occulta 10.0
13 pleomorphic lipoma 10.0
14 meningocele 10.0
15 benign ependymoma 10.0
16 myxopapillary ependymoma 10.0
17 ependymoma 10.0
18 anorectal anomalies 10.0
19 epidermoid cysts 10.0
20 anus, imperforate 10.0
21 oeis complex 10.0
22 wilms tumor 5 10.0
23 anxiety 10.0
24 spondylocostal dysostosis 3, autosomal recessive 10.0
25 wilms tumor 6 10.0
26 cloacal exstrophy 10.0
27 dysostosis 10.0
28 hypertrichosis 10.0
29 mature teratoma 10.0
30 aplasia cutis congenita 10.0
31 dwarfism 10.0
32 sirenomelia 10.0
33 syringohydromyelia 10.0
34 encephalocraniocutaneous lipomatosis 10.0
35 neurogenic bladder 10.0
36 lipomatosis 10.0
37 chiari malformation type i 9.9
38 diabetes insipidus, nephrogenic, autosomal 9.9
39 pilonidal sinus 9.9
40 diastematomyelia 9.9
41 osteoid osteoma 9.9
42 opitz-kaveggia syndrome 9.9
43 neural tube defects, folate-sensitive 9.9
44 muscle hypertrophy 9.9
45 polyglucosan body myopathy 1 with or without immunodeficiency 9.9
46 charcot-marie-tooth disease 9.9
47 craniosynostosis 9.9
48 hydrocephalus 9.9
49 lymphoma 9.9
50 klippel-feil syndrome 9.9

Graphical network of the top 20 diseases related to Tethered Cord Syndrome:



Diseases related to Tethered Cord Syndrome

Symptoms & Phenotypes for Tethered Cord Syndrome

Drugs & Therapeutics for Tethered Cord Syndrome

Drugs for Tethered Cord Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 2 59-66-5 1986
2 Natriuretic Agents Phase 2
3 diuretics Phase 2
4 Anticonvulsants Phase 2
5 Carbonic Anhydrase Inhibitors Phase 2
6 Dermatologic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence Unknown status NCT01867268 Phase 2 Acetazolamide
2 Genetics of Neural Tube Defects Unknown status NCT01253746
3 Hemangioma Associated With High Rates of Morbidity Completed NCT00394888 Not Applicable
4 Treatment of Persistent Urinary Incontinence in Children Completed NCT00124046 Not Applicable
5 Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome Recruiting NCT03262844 Not Applicable
6 Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase Recruiting NCT03702010 Not Applicable
7 Spinal Deformity Intraoperative Monitoring. Not yet recruiting NCT03880292 Not Applicable
8 Comparing Surgical Decompression Versus Conservative Treatment in Incomplete Spinal Cord Injury Terminated NCT01367405 Not Applicable
9 Intermittent Positive-Pressure Breathing Effects in Patients With High Spinal Cord Injury Terminated NCT00476866 Not Applicable
10 Magnetic Resonance Imaging of the Spine Withdrawn NCT01382290 Not Applicable

Search NIH Clinical Center for Tethered Cord Syndrome

Genetic Tests for Tethered Cord Syndrome

Anatomical Context for Tethered Cord Syndrome

MalaCards organs/tissues related to Tethered Cord Syndrome:

42
Spinal Cord, Skin, Testes, Colon

Publications for Tethered Cord Syndrome

Articles related to Tethered Cord Syndrome:

(show top 50) (show all 283)
# Title Authors Year
1
Prof. Shokei Yamada: An International Neurosurgeon, Regarded as Father Figure for Adult Tethered Cord Syndrome Management and Dedicated Life for the Advancement of Intracranial Arteriovenous Malformation Surgery. ( 30937074 )
2019
2
Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery. ( 30280214 )
2019
3
Assessing Spinal Cord Injury Area in Patients with Tethered Cord Syndrome by Diffusion Tensor Imaging. ( 30928592 )
2019
4
Secondary sacral tethered cord syndrome after treatment of secondary cervical syringomyelia. ( 30470654 )
2019
5
Spinal Column Shortening for Secondary Tethered Cord Syndrome in Children: 2-Dimensional Operative Video. ( 30169877 )
2019
6
Spinal Cord Stimulation in Adult Tethered Cord Syndrome: Case Report and Review of the Literature. ( 30415046 )
2019
7
Dynamic magnetic resonance imaging parameters for objective assessment of the magnitude of tethered cord syndrome in patients with spinal dysraphism. ( 30456429 )
2019
8
Microsurgical efficacy in 326 children with tethered cord syndrome: a retrospective analysis. ( 30531089 )
2019
9
Homogeneous Spinal-Shortening Axial Decompression as a Revision Surgery After Untethering Surgery in Pediatric Patients with Tethered Cord Syndrome. ( 30660897 )
2019
10
Dermoid sinus type VI associated with spina bifida and tethered cord syndrome in a French Bulldog. ( 30734666 )
2019
11
Homogeneous Spinal-Shortening Axial Decompression for Tethered Cord Syndrome: Modified Spinal Column Shortening. ( 30928585 )
2019
12
Surgical treatment of tethered cord syndrome-comparing the results of surgeries with and without electrophysiological monitoring. ( 30963241 )
2019
13
Tethered Cord Syndrome-Role of Early Surgery. ( 31105399 )
2019
14
Thoracolumbar spinal neurenteric cyst with tethered cord syndrome and extreme cervical lordosis in a child: A case report and literature review. ( 29668630 )
2018
15
Factors affecting the surgical outcomes of tethered cord syndrome in adults: a retrospective study. ( 28293750 )
2018
16
Evaluation and management of tethered cord syndrome in occult spinal dysraphism: Recommendations from the international children's continence society. ( 28792087 )
2018
17
Transhiatal Approach to Filum Terminale Externum Sectioning in Adult Patient With Tethered Cord Syndrome: Case Report. ( 28961973 )
2018
18
Clinical evaluation of an innovative operative procedure in the treatment of the tethered cord syndrome. ( 29055742 )
2018
19
Prognosis of surgical treatment of the tethered cord syndrome in children. ( 29067499 )
2018
20
Adult Tethered Cord Syndrome Following Chiari Decompression. ( 29409774 )
2018
21
Spine-shortening osteotomy for patients with tethered cord syndrome: a systematic review and meta-analysis. ( 29528274 )
2018
22
Tailored Strategies to Manage Cerebrospinal Fluid Leaks or Pseudomeningocele After Surgery for Tethered Cord Syndrome. ( 29605699 )
2018
23
Clinical Outcomes of Primary and Revision Untethering Surgery in Patients with Tethered Cord Syndrome and Spinal Bifida. ( 29649647 )
2018
24
Adult Versus Pediatric Tethered Cord Syndrome: Clinicoradiological Differences and its Management. ( 29682019 )
2018
25
Surgical Outcomes of Pediatric Patients with Asymptomatic Tethered Cord Syndrome. ( 29879784 )
2018
26
Using subdural strip electrodes to define functional sensory nerves and the most inferior functional portion of the conus medullaris during detethering surgeries for tethered cord syndrome: a pilot study. ( 30004314 )
2018
27
Unusual Clinical Presentation and Association of Cranial Dermoid Tumor and Tethered Cord Syndrome. ( 30408795 )
2018
28
Clubfoot and Tethered Cord Syndrome: Results of Treatment With the Ponseti Method. ( 28178095 )
2017
29
Klippel-Feil Syndrome Associated with Sacral Agenesis, Low Lying Cord, Lipomyelomeningocele and Split Cord Malformation Presenting with Tethered Cord Syndrome: Pentads Neural Tube Defects Spread along Whole Spinal Axis. ( 28553382 )
2017
30
Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults. ( 28362188 )
2017
31
Recurrent Abortion and Tethered Cord Syndrome Caused by Anterior Sacral Meningocele: A Report of a Rare Case with a Review of the Literature. ( 28279771 )
2017
32
Management of concomitant scoliosis and tethered cord syndrome in non-spina bifida pediatric population. ( 28695338 )
2017
33
Tethered cord syndrome with spina bifida aperta in cats: two case reports of different types. ( 28546867 )
2017
34
Trends in the presentation, surgical treatment, and outcomes of tethered cord syndrome: A nationwide study from 2001 to 2010. ( 28342704 )
2017
35
Mini-open spinal column shortening for the treatment of adult tethered cord syndrome. ( 28789957 )
2017
36
Progressive Kyphosis Associated with Tethered Cord Syndrome Treated by Posterior Vertebral Column Resection in a Pediatric Patient. ( 28817819 )
2017
37
Dynamic Lumbosacral Magnetic Resonance Imaging in a Dog with Tethered Cord Syndrome with a Tight Filum Terminale. ( 28868301 )
2017
38
Chiari type I malformation with occult tethered cord syndrome in a child: A case report. ( 28984782 )
2017
39
Spinal Shortening for Recurrent Tethered Cord Syndrome via a Lateral Retropleural Approach: A Novel Operative Technique. ( 29104840 )
2017
40
Duplicated filum terminale in non-split cord malformations: An underrecognized cause for treatment failure in tethered cord syndrome. ( 27735228 )
2017
41
Comparison of Electrophysiological Outcomes of Tethered Cord Syndrome and Spinal Intradural Tumors: A Retrospective Clinical Study. ( 27593807 )
2017
42
Management of Tethered Cord Syndrome in Adults: Experience of 23 Cases. ( 27593774 )
2017
43
Co-existing spinal intradural ependymal cyst and sacral Tarlov cyst in adult-onset tethered cord syndrome with syringomyelia: Case report and literature review. ( 27843691 )
2016
44
Painful leg and moving toes syndrome in secondary tethered cord syndrome. ( 25664587 )
2016
45
Surgical Outcome of Children and Adolescents with Tethered Cord Syndrome. ( 27790325 )
2016
46
Surgical treatments on adult tethered cord syndrome: A retrospective study. ( 27861396 )
2016
47
Prenatal Ultrasound Evaluation of the Position of Conus Medullaris for the Diagnosis of Tethered Cord Syndrome. ( 27870788 )
2016
48
Poster 342 Tethered Cord Syndrome in a Patient with 40-Year History of Spinal Cord Injury: A Case Report. ( 27673095 )
2016
49
Variation in Outcome in Tethered Cord Syndrome. ( 27559452 )
2016
50
Comparative Study of Untethering and Spine-Shortening Surgery for Tethered Cord Syndrome in Adults. ( 27555994 )
2016

Variations for Tethered Cord Syndrome

Expression for Tethered Cord Syndrome

Search GEO for disease gene expression data for Tethered Cord Syndrome.

Pathways for Tethered Cord Syndrome

GO Terms for Tethered Cord Syndrome

Sources for Tethered Cord Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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