Aliases & Classifications for Tetraploidy

MalaCards integrated aliases for Tetraploidy:

Name: Tetraploidy 53 59 73
Tetraploidy Syndrome 53

Classifications:



External Ids:

Orphanet 59 ORPHA3305
MESH via Orphanet 45 D057891
UMLS via Orphanet 74 C0333694
ICD10 via Orphanet 34 Q92.7
UMLS 73 C0333694

Summaries for Tetraploidy

MalaCards based summary : Tetraploidy, also known as tetraploidy syndrome, is related to neuroblastoma and leukemia. An important gene associated with Tetraploidy is LATS1 (Large Tumor Suppressor Kinase 1), and among its related pathways/superpathways are Pathways in cancer and TNFR1 Pathway. The drugs Omeprazole and Melatonin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, skin and colon, and related phenotypes are hydronephrosis and cleft palate

Related Diseases for Tetraploidy

Diseases related to Tetraploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 27.9 NGFR PARP1 TP53
2 leukemia 10.3
3 myeloid leukemia 10.2
4 leukemia, acute myeloid 10.2
5 triploidy 10.0
6 neuronitis 10.0
7 acute leukemia 9.9
8 uterine corpus serous adenocarcinoma 9.9 BRCA2 TP53
9 soft tissue sarcoma 9.9 LATS1 TP53
10 synchronous bilateral breast carcinoma 9.9 BRCA2 TP53
11 fallopian tube adenocarcinoma 9.9 BRCA2 TP53
12 glycogen-rich clear cell breast carcinoma 9.9 BRCA2 TP53
13 immunodeficiency-centromeric instability-facial anomalies syndrome 1 9.9
14 lymphoma 9.9
15 aging 9.9
16 alzheimer disease 9.9
17 colorectal cancer 9.9
18 primary peritoneal carcinoma 9.8 BRCA2 TP53
19 mutagen sensitivity 9.8 BRCA2 TP53
20 bladder transitional cell papilloma 9.8 PARP1 TP53
21 acinar cell carcinoma 9.8 BRCA2 TP53
22 pre-malignant neoplasm 9.8 BRCA2 TP53
23 fallopian tube carcinoma 9.8 BRCA2 TP53
24 hydatidiform mole, recurrent, 1 9.8
25 myeloma, multiple 9.8
26 lymphoblastic leukemia 9.8
27 leukemia, acute lymphoblastic 9.8
28 gestational trophoblastic neoplasm 9.8
29 myelodysplastic syndrome 9.8
30 diabetic neuropathy 9.8 NGFR PARP1
31 ovarian cancer 1 9.8 BRCA2 TP53
32 malignant ovarian surface epithelial-stromal neoplasm 9.8 BRCA2 TP53
33 ovary epithelial cancer 9.7 BRCA2 TP53
34 breast carcinoma in situ 9.7 BRCA2 TP53
35 splenic diffuse red pulp small b-cell lymphoma 9.7 NOTCH1 TP53
36 invasive bladder transitional cell carcinoma 9.7 NOTCH1 TP53
37 female breast cancer 9.7 BRCA2 TP53
38 cellular schwannoma 9.7 NGFR TP53
39 bone squamous cell carcinoma 9.7 NOTCH1 TP53
40 ocular cancer 9.7 BRCA2 TP53
41 schneiderian carcinoma 9.7 NOTCH1 TP53
42 spinal cord astrocytoma 9.7 NOTCH1 TP53
43 peutz-jeghers syndrome 9.7 BRCA2 TP53
44 richter's syndrome 9.7 NOTCH1 TP53
45 neural tube defects 9.6
46 neutropenia 9.6
47 polycystic ovary syndrome 9.6
48 acute leukemia of ambiguous lineage 9.6
49 ulcerative colitis 9.6
50 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.6

Graphical network of the top 20 diseases related to Tetraploidy:



Diseases related to Tetraploidy

Symptoms & Phenotypes for Tetraploidy

Human phenotypes related to Tetraploidy:

59 32 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydronephrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000126
2 cleft palate 59 32 occasional (7.5%) Occasional (29-5%) HP:0000175
3 microcephaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0000252
4 short philtrum 59 32 frequent (33%) Frequent (79-30%) HP:0000322
5 micrognathia 59 32 frequent (33%) Frequent (79-30%) HP:0000347
6 preauricular skin tag 59 32 occasional (7.5%) Occasional (29-5%) HP:0000384
7 convex nasal ridge 59 32 hallmark (90%) Very frequent (99-80%) HP:0000444
8 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
9 arnold-chiari malformation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002308
10 abnormality of chromosome segregation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002916
11 radial club hand 59 32 frequent (33%) Frequent (79-30%) HP:0004059
12 biparietal narrowing 59 32 hallmark (90%) Very frequent (99-80%) HP:0004422
13 aplasia/hypoplasia of the lungs 59 32 occasional (7.5%) Occasional (29-5%) HP:0006703
14 aplasia/hypoplasia affecting the eye 59 32 occasional (7.5%) Occasional (29-5%) HP:0008056
15 renal hypoplasia/aplasia 59 32 occasional (7.5%) Occasional (29-5%) HP:0008678
16 aplasia/hypoplasia of the thymus 59 32 occasional (7.5%) Occasional (29-5%) HP:0010515
17 hypoplasia of the ear cartilage 59 32 frequent (33%) Frequent (79-30%) HP:0100720

GenomeRNAi Phenotypes related to Tetraploidy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA2 NOTCH1

MGI Mouse Phenotypes related to Tetraploidy:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 BRCA2 LATS1 NGFR NOTCH1 PARP1 TP53
2 growth/size/body region MP:0005378 9.97 BRCA2 LATS1 NGFR NOTCH1 PARP1 TP53
3 homeostasis/metabolism MP:0005376 9.91 BRCA2 LATS1 NGFR NOTCH1 PARP1 TP53
4 integument MP:0010771 9.88 BRCA2 LATS1 NGFR NOTCH1 PARP1 TP53
5 hematopoietic system MP:0005397 9.85 BRCA2 NGFR NOTCH1 PARP1 TP53
6 digestive/alimentary MP:0005381 9.81 TP53 BRCA2 NGFR NOTCH1
7 mortality/aging MP:0010768 9.8 BRCA2 LATS1 NGFR NOTCH1 PARP1 TP53
8 hearing/vestibular/ear MP:0005377 9.78 NGFR NOTCH1 PARP1 TP53
9 liver/biliary system MP:0005370 9.67 LATS1 NGFR NOTCH1 TP53
10 nervous system MP:0003631 9.63 BRCA2 LATS1 NGFR NOTCH1 PARP1 TP53
11 neoplasm MP:0002006 9.56 BRCA2 LATS1 NOTCH1 TP53
12 normal MP:0002873 9.35 BRCA2 LATS1 NGFR NOTCH1 TP53
13 renal/urinary system MP:0005367 8.92 NGFR NOTCH1 PARP1 TP53

Drugs & Therapeutics for Tetraploidy

Drugs for Tetraploidy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
2
Melatonin Approved, Nutraceutical, Vet_approved Phase 3 73-31-4 896
3 Central Nervous System Depressants Phase 3
4 Gastrointestinal Agents Phase 3
5 Antacids Phase 3
6 Antioxidants Phase 3
7 Protective Agents Phase 3
8 Proton Pump Inhibitors Phase 3
9 Anti-Ulcer Agents Phase 3
10
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
11
Methylphenidate Approved, Investigational Phase 2 113-45-1 4158
12
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
13 Central Nervous System Stimulants Phase 2
14 Neurotransmitter Agents Phase 2
15 Neurotransmitter Uptake Inhibitors Phase 2
16 Dopamine Agents Phase 2
17 Dopamine Uptake Inhibitors Phase 2
18 Histone Deacetylase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study Unknown status NCT01566474 Phase 3 Omeprazole;Melatonin
2 Effects of Methylphenidate on Cellular Abnormalities in Children With Attention Deficit Hyperactivity Disorder (ADHD) Completed NCT00409708 Phase 2 Extended Release Methylphenidate (Ritalin LA ) plus Behavior Therapy
3 Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma Active, not recruiting NCT01175980 Phase 2 Vorinostat

Search NIH Clinical Center for Tetraploidy

Genetic Tests for Tetraploidy

Anatomical Context for Tetraploidy

MalaCards organs/tissues related to Tetraploidy:

41
Myeloid, Skin, Colon, Eye, Thymus, Lung, Ovary

Publications for Tetraploidy

Articles related to Tetraploidy:

(show top 50) (show all 203)
# Title Authors Year
1
Tetraploidy in cancer and its possible link to aging. ( 29949679 )
2018
2
Genetic differentiation and spatiotemporal history of diploidy and tetraploidy of<i>Clintonia udensis</i>. ( 29238551 )
2017
3
Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib. ( 29296799 )
2017
4
Near Tetraploidy Acute Myeloid Leukemia in Long-term Remission with Persistent Clonal Hematopoiesis with del(20)(q12q13). ( 29093395 )
2017
5
Tetraploidy acute myeloid leukaemia after chromosome 16 inversion. ( 28331025 )
2017
6
The characterisation of microsatellite markers reveals tetraploidy in the Greater Water Parsnip, Sium latifolium (Apiaceae). ( 28606172 )
2017
7
Neuronal tetraploidy in Alzheimer and aging. ( 29070731 )
2017
8
Tetraploidy/near-tetraploidy acute myeloid leukemia. ( 27951415 )
2016
9
A female newborn having mosaicism with near-tetraploidy and trisomy 18. ( 26789424 )
2016
10
Effects of tetraploidy induction on rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) proteome at early stages of development. ( 27561891 )
2016
11
Erythrophagocytosis in T-cell type acute lymphoblastic leukaemia with near-tetraploidy. ( 27520437 )
2016
12
BILATERAL OPTIC NERVE COLOBOMAS IN INFANT WITH TETRAPLOIDY. ( 26579595 )
2016
13
Tetraploidy Enhances Boron-Excess Tolerance in Carrizo Citrange (Citrus sinensis L. Osb. A9 Poncirus trifoliata L. Raf.). ( 27252717 )
2016
14
Tetraploidy enhances the ability to exclude chloride from leaves in carrizo citrange seedlings. ( 27589221 )
2016
15
Aneuploidy and Tetraploidy as Distinct Patterns During Melanomagenesis. ( 27466867 )
2016
16
Stimulation of Cell Elongation by Tetraploidy in Hypocotyls of Dark-Grown Arabidopsis Seedlings. ( 26244498 )
2015
17
Tetraploidy and CIN: a dangerous combination. ( 26517196 )
2015
18
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer. ( 25916844 )
2015
19
Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia. ( 25563333 )
2015
20
Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice. ( 25847236 )
2015
21
Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature. ( 25197424 )
2014
22
The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. ( 24775809 )
2014
23
Somatic embryogenesis, tetraploidy, and variant leaf morphology in transgenic diploid strawberry (Fragaria vesca subspecies vesca 'Hawaii 4'). ( 24418064 )
2014
24
Tetraploidy and tumor development. ( 25526024 )
2014
25
Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites. ( 24280829 )
2013
26
Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. ( 23616554 )
2013
27
Two cases of near-tetraploidy in acute leukemias of ambiguous lineage. ( 24003431 )
2013
28
Tetraploidy in hydatidiform moles. ( 23633551 )
2013
29
Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy. ( 23651194 )
2013
30
Tetraploidy with double t(15;17)(q22;q21) in acute promyelocytic leukaemia. ( 23250036 )
2013
31
Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints. ( 23321641 )
2013
32
Tetraploidy with double t(11;18) of recurrent MALT lymphoma in buccal mucosa: a case report. ( 22669146 )
2012
33
A framework genetic map for Miscanthus sinensis from RNAseq-based markers shows recent tetraploidy. ( 22524439 )
2012
34
Doubling the deck: Tetraploidy induces chromosome shuffling and cancer. ( 22918235 )
2012
35
Tetraploidy in BRCA2 breast tumours. ( 22133571 )
2012
36
Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). ( 22284693 )
2012
37
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. ( 22250643 )
2012
38
Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy. ( 21354560 )
2011
39
AML associated with extensive erythrophagocytosis and tetraploidy. ( 21790789 )
2011
40
Genomic landscape of the Alzheimer's disease brain: chromosome instability--aneuploidy, but not tetraploidy--mediates neurodegeneration. ( 21135562 )
2011
41
Application of touch FISH in the study of mosaic tetraploidy and maternal cell contamination in pregnancy losses. ( 20676750 )
2010
42
Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. ( 20018664 )
2010
43
Enlarged and prominent nucleus may be indicative of tetraploidy: a laboratory study of a rare near-tetraploidy in a child patient with acute myelogenous leukemia AML-M4. ( 19816206 )
2010
44
Near-tetraploidy clone can evolve from a hyperdiploidy clone and cause resistance to lenalidomide and bortezomib in a multiple myeloma patient. ( 20138360 )
2010
45
Mosaic and complete tetraploidy in live-born infants: two new patients and review of the literature. ( 20305547 )
2010
46
Persistent telomere damage induces bypass of mitosis and tetraploidy. ( 20371347 )
2010
47
Following tetraploidy in maize, a short deletion mechanism removed genes preferentially from one of the two homologs. ( 20613864 )
2010
48
Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. ( 20585523 )
2010
49
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. ( 20098673 )
2010
50
A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR). ( 20436277 )
2010

Variations for Tetraploidy

Expression for Tetraploidy

Search GEO for disease gene expression data for Tetraploidy.

Pathways for Tetraploidy

Pathways related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.39 BRCA2 NOTCH1 TP53
2
Show member pathways
12.39 NGFR PARP1 TP53
3
Show member pathways
12.33 NGFR PARP1 TP53
4
Show member pathways
12.25 BRCA2 NOTCH1 TP53
5
Show member pathways
12.21 BRCA2 NOTCH1 TP53
6
Show member pathways
12.11 BRCA2 PARP1 TP53
7
Show member pathways
11.4 BRCA2 TP53
8 11.27 BRCA2 LATS1 TP53
9
Show member pathways
11.08 NGFR TP53
10 10.98 NOTCH1 TP53
11 10.64 NOTCH1 PARP1

GO Terms for Tetraploidy

Cellular components related to Tetraploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 BRCA2 NGFR NOTCH1 PARP1 TP53

Biological processes related to Tetraploidy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.71 BRCA2 PARP1 TP53
2 regulation of cell proliferation GO:0042127 9.58 BRCA2 NGFR NOTCH1
3 double-strand break repair via homologous recombination GO:0000724 9.56 BRCA2 PARP1
4 keratinocyte differentiation GO:0030216 9.55 LATS1 NOTCH1
5 double-strand break repair GO:0006302 9.52 BRCA2 PARP1
6 cellular response to UV GO:0034644 9.51 PARP1 TP53
7 nucleotide-excision repair GO:0006289 9.49 BRCA2 TP53
8 cell aging GO:0007569 9.48 BRCA2 TP53
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.46 BRCA2 TP53
10 cellular response to amyloid-beta GO:1904646 9.43 NGFR PARP1
11 positive regulation of protein localization to nucleus GO:1900182 9.37 NGFR PARP1
12 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.32 NGFR TP53
13 response to X-ray GO:0010165 9.26 BRCA2 TP53
14 positive regulation of apoptotic process GO:0043065 9.26 LATS1 NGFR NOTCH1 TP53
15 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 BRCA2 TP53
16 response to gamma radiation GO:0010332 8.8 BRCA2 PARP1 TP53

Molecular functions related to Tetraploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.33 LATS1 PARP1 TP53
2 enzyme binding GO:0019899 9.13 NOTCH1 PARP1 TP53
3 estrogen receptor binding GO:0030331 8.62 LATS1 PARP1

Sources for Tetraploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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