MCID: THL010
MIFTS: 32

Thalassemia Minor

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Thalassemia Minor

MalaCards integrated aliases for Thalassemia Minor:

Name: Thalassemia Minor 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0080774

Summaries for Thalassemia Minor

Disease Ontology : 12 A beta thalassemia that has material basis in one HBB gene mutation without typical thalassemia symptoms, but may have some symptoms of anemia.

MalaCards based summary : Thalassemia Minor is related to thrombocytopenia with beta-thalassemia, x-linked and thalassemia. An important gene associated with Thalassemia Minor is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Malaria and African trypanosomiasis. Affiliated tissues include bone marrow, kidney and eye, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 74 Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of... more...

Related Diseases for Thalassemia Minor

Diseases related to Thalassemia Minor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia with beta-thalassemia, x-linked 31.8 KLF1 GATA1
2 thalassemia 31.5 HBB HBA2 GATA1
3 iron metabolism disease 30.9 HBB EPO
4 beta-thalassemia 30.8 UGT1A1 PON1 KLF1 HBB HBA2 GATA1
5 hypochromic microcytic anemia 30.3 HBB HBA2
6 proteinuria, chronic benign 30.2 COL4A5 B2M
7 glucosephosphate dehydrogenase deficiency 30.1 UGT1A1 HBB
8 splenomegaly 30.1 HBA2 EPO
9 hemoglobin e disease 30.0 KLF1 HBB
10 microcytic anemia 29.9 HBB HBA2 EPO
11 hemochromatosis, type 1 29.9 PON1 HBB EPO B2M
12 vitamin b12 deficiency 29.8 PON1 EPO
13 hemoglobinopathy 29.5 UGT1A1 KLF1 HBB HBA2 GATA1 EPO
14 alport syndrome 29.5 PKD1 COL4A5 CD151
15 hemolytic anemia 29.4 UGT1A1 KLF1 HBB HBA2 EPO
16 sickle cell disease 29.4 UGT1A1 HBB HBA2 EPO
17 alpha-thalassemia 29.4 UGT1A1 KLF1 HBB HBA2 GATA1 EPO
18 deficiency anemia 29.3 PON1 KLF1 HBB HBA2 GATA1 EPO
19 hemoglobin h disease 29.2 KLF1 HBB HBA2 EPO
20 sickle cell anemia 29.2 UGT1A1 HBB HBA2 EPO
21 kidney disease 28.6 PON1 PKD1 EPO COL4A5 B2M
22 end stage renal disease 28.4 PON1 PKD1 EPO COL4A5 B2M
23 chronic kidney disease 28.4 PON1 PKD1 EPO COL4A5 B2M
24 polycystic kidney disease 28.3 PKD1 HBA2 EPO COL4A5 B2M
25 nephropathy with pretibial epidermolysis bullosa and deafness 11.1
26 iron deficiency anemia 10.5
27 beta-thalassemia major 10.3
28 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 10.2 KLF1 HBB
29 hemosiderosis 10.2
30 anemia, hypochromic microcytic, with iron overload 1 10.2
31 rare hereditary hemochromatosis 10.2
32 anemia, congenital dyserythropoietic, type iii 10.2 KLF1 GATA1
33 anemia, congenital dyserythropoietic, type ib 10.2 KLF1 GATA1
34 cutaneous porphyria 10.2 KLF1 GATA1
35 anemia, congenital dyserythropoietic, type iv 10.1 KLF1 GATA1
36 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 10.1 KLF1 HBB
37 liver disease 10.1
38 splenic sequestration 10.1 HBB EPO
39 inflammatory bowel disease 27 10.1 GATA1 EPO
40 hemoglobin zurich 10.1 HBB HBA2
41 spherocytosis, type 2 10.1 KLF1 HBB GATA1
42 glutathione peroxidase deficiency 10.1 HBB HBA2
43 spherocytosis, type 4 10.1 KLF1 HBB GATA1
44 spherocytosis, type 3 10.1 KLF1 HBB GATA1
45 major affective disorder 1 10.1
46 methemoglobinemia, beta-globin type 10.1 HBB HBA2
47 uremic neuropathy 10.1 EPO B2M
48 histiocytosis-lymphadenopathy plus syndrome 10.0 HBB HBA2
49 fetal hemoglobin quantitative trait locus 1 10.0
50 thrombosis 10.0

Graphical network of the top 20 diseases related to Thalassemia Minor:



Diseases related to Thalassemia Minor

Symptoms & Phenotypes for Thalassemia Minor

MGI Mouse Phenotypes related to Thalassemia Minor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 B2M CD151 COL4A5 EPO GATA1 PKD1
2 hematopoietic system MP:0005397 9.76 B2M CD151 COL4A5 EPO GATA1 HBA2
3 homeostasis/metabolism MP:0005376 9.61 B2M CD151 COL4A5 EPO GATA1 HBA2
4 integument MP:0010771 9.17 B2M CD151 EPO GATA1 HBA2 KLF1

Drugs & Therapeutics for Thalassemia Minor

Search Clinical Trials , NIH Clinical Center for Thalassemia Minor

Genetic Tests for Thalassemia Minor

Anatomical Context for Thalassemia Minor

MalaCards organs/tissues related to Thalassemia Minor:

40
Bone Marrow, Kidney, Eye, Thyroid, Whole Blood, Liver, Skin

Publications for Thalassemia Minor

Articles related to Thalassemia Minor:

(show top 50) (show all 525)
# Title Authors PMID Year
1
Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious. 61
32460294 2021
2
Hemochromatosis in a β-thalassemia minor patient with H63D homozygous mutation: A case report. 61
33363736 2020
3
Septicemic melioidosis complicating undiagnosed chronic kidney disease and beta-thalassemia minor in a Bangladeshi farmer. 61
33565456 2020
4
Lupus erythematosus tumidus in an adolescent with beta thalassemia minor successfully controlled with hydroxychloroquine. 61
33037863 2020
5
Cold Agglutinin Disease and Hemolytic Crisis After Hypothermic Circulatory Arrest in a Patient With Beta-Thalassemia Minor. 61
32245720 2020
6
Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with Beta-Thalassemia Minor for Severe Aplastic Anemia. 61
33020370 2020
7
Determination of mutations in iron regulating genes of beta thalassemia major patients of Khyber Pakhtunkhwa, Pakistan. 61
32588561 2020
8
Discriminant indexes to simplify the differential diagnosis between iron deficiency anemia and thalassemia minor in individuals with microcytic anemia. 61
33027458 2020
9
Letter to the Editor: Portal Vein Thrombosis with Splenic Infarct in β-Thalassemia Minor at High Altitude. 61
32498614 2020
10
The pedigree analysis and prenatal diagnosis of Hong Kongαα Thalassemia and the sequence analysis of Hong Kongαα Allele. 61
32419356 2020
11
Atypical hemolytic uremic syndrome with peripheral gangrene and homocysteinemia in a child. 61
32728451 2020
12
Evaluation of Adipokines Concentration in Iraqi Patients with Major and Minor Beta Thalassemia. 61
33178871 2020
13
The effect of mother's β-thalassemia minor on placental histology and neonatal outcomes. 61
32495664 2020
14
Sexual dysfunction in female subjects with beta-thalassemia minor. 61
32341453 2020
15
The curious case of hemoglobin DC disease masquerading as sickle cell anemia. 61
32499906 2020
16
Antioxidant Activity and Oxidative Stress Status in Maternal Serum of β-thalassemic Mothers Carrying β-thalassemic Major and Normal Fetuses. 61
32064989 2020
17
Coinheritance of beta-thalassemia minor and hereditary pyropoikilocytosis: case report. 61
31080003 2020
18
Prevalence of Congenital Hemolytic Disorders in Denmark, 2000-2016. 61
32547240 2020
19
Common variable immune deficiency, central diabetes insipidus, and anemia. 61
33437189 2020
20
A comparative study of temperamental, behavioral, and cognitive changes in thalassemia major, thalassemia minor, and normal population. 61
31896869 2019
21
Multifactorial Painful Leg Ulcers Due to Hyperhomocysteinemia, Plasminogen Activator Inhibitor-1 4G/5G Heterozygote Gene Mutation, and Beta Thalassemia Minor: A Case Report. 61
31409160 2019
22
Hereditary methemoglobinemia caused by Hb M-Hyde Park (Hb M-Akita) (HBB:c.277C > T; p.His93Tyr). 61
31267164 2019
23
Increased risk of arterial thromboembolic events in transfusion-naïve thalassemia: a nationwide population-based study. 61
31126995 2019
24
Impact of β-thalassemia trait carrier state on inflammatory status in patients with newly diagnosed hypertension. 61
30865135 2019
25
Intraocular pressure in subjects with beta-thalassemia minor. 61
30810618 2019
26
Particular etiology in a case of peripheral tetraparesis. 61
31110746 2019
27
[Epidemiological, clinico-biological, therapeutic and evolutionary aspects of β-thalassemia in Morocco]. 61
30998197 2019
28
Increased Prevalence of Thalassemia in Young People in Korea: Impact of Increasing Immigration. 61
30430775 2019
29
Role of red blood cells "annexin V" and platelets "P-selectin" in patients with thalassemia. 61
30028953 2019
30
[Prevalence and Genetic Analysis of β-Thalassemia in Neonates in Wuhan Area of China]. 61
30738465 2019
31
Prevalence of hemoglobinopathies in the Brazilian adult population: National Health Survey 2014-2015. 61
31596378 2019
32
Investigating the Reliability of HbA1c Monitoring for Blood Glucose Control During Late Pregnancy in Patients with Gestational Diabetes Mellitus (GDM) with and without β-Thalassemia Minor. 61
30284689 2018
33
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters. 61
30184319 2018
34
Glutaric acidemia type II patient with thalassemia minor and novel electron transfer flavoprotein-A gene mutations: A case report and review of literature. 61
30510944 2018
35
Beta-Thalassemia Minor Manifesting as Proliferative Retinopathy. 61
30395680 2018
36
HBG2 -158 (C>T) polymorphism and its contribution to fetal hemoglobin variability in Iraqi Kurds with beta-thalassemia minor. 61
30498305 2018
37
Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor. 61
30483041 2018
38
Results of Coexistence of β-Thalassemia Minor in Hb H Disease Patients. 61
30614310 2018
39
Raman characterizations of red blood cells with β-thalassemia using laser tweezers Raman spectroscopy. 61
30278579 2018
40
β-Thalassemia heterozygote state detrimentally affects health expectation. 61
29934240 2018
41
[Pernicious anemia in a thalassemic patient - difficulties of the diagnosis]. 61
30099903 2018
42
Compound Heterozygosity for Hb D-Ibadan (HBB: c.263C>A) and Hb C (HBB: c.19G>A). 61
30604644 2018
43
β-Thalassemia intermedia: a comprehensive overview and novel approaches. 61
29380178 2018
44
Should sex differences be considered when applying mathematical indices and formulas for discriminating β- thalassemia minor from iron deficiency? 61
30202778 2018
45
Nonischemic Priapism in Childhood: A Case Series and Review of Literature. 61
28346955 2018
46
A KLF1 gene mutation causes β-thalassemia minor in a Chinese family. 61
29393578 2018
47
Coexistence of urticaria pigmentosa and thalassemia minor in a young adult. 61
29785323 2018
48
A large subchorionic placental cyst with thalassemia minor without fetal growth restriction. 61
29458891 2018
49
Assessing posterior ocular structures in β-thalassemia minor. 61
28054212 2018
50
Presacral and intrathoracic extramedullary hematopoiesis in a patient with β thalassemia minor. 61
27148799 2018

Variations for Thalassemia Minor

Expression for Thalassemia Minor

Search GEO for disease gene expression data for Thalassemia Minor.

Pathways for Thalassemia Minor

Pathways related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 HBB HBA2
2 10.72 HBB HBA2
3
Show member pathways
10.5 HBB HBA2
4 10.48 KLF1 GATA1 EPO

GO Terms for Thalassemia Minor

Cellular components related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.88 PON1 HBB HBA2 EPO COL4A5 B2M
2 extracellular space GO:0005615 9.8 PON1 HBB HBA2 EPO COL4A5 B2M
3 cell surface GO:0009986 9.67 PKD1 EPO CD151 B2M
4 tertiary granule lumen GO:1904724 9.43 HBB B2M
5 blood microparticle GO:0072562 9.43 PON1 HBB HBA2
6 endocytic vesicle lumen GO:0071682 9.16 HBB HBA2
7 hemoglobin complex GO:0005833 8.96 HBB HBA2
8 haptoglobin-hemoglobin complex GO:0031838 8.62 HBB HBA2

Biological processes related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell death GO:0010942 9.4 HBB HBA2
2 platelet aggregation GO:0070527 9.37 HBB GATA1
3 bicarbonate transport GO:0015701 9.32 HBB HBA2
4 acute-phase response GO:0006953 9.26 UGT1A1 EPO
5 hydrogen peroxide catabolic process GO:0042744 9.16 HBB HBA2
6 oxygen transport GO:0015671 8.96 HBB HBA2
7 erythrocyte differentiation GO:0030218 8.8 KLF1 GATA1 EPO

Molecular functions related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.32 HBB HBA2
2 oxygen binding GO:0019825 9.26 HBB HBA2
3 oxygen carrier activity GO:0005344 9.16 HBB HBA2
4 organic acid binding GO:0043177 8.96 HBB HBA2
5 haptoglobin binding GO:0031720 8.62 HBB HBA2

Sources for Thalassemia Minor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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