MCID: THL010
MIFTS: 30

Thalassemia Minor

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Thalassemia Minor

MalaCards integrated aliases for Thalassemia Minor:

Name: Thalassemia Minor 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0080774

Summaries for Thalassemia Minor

Disease Ontology : 12 A beta thalassemia that has material basis in one HBB gene mutation without typical thalassemia symptoms, but may have some symptoms of anemia.

MalaCards based summary : Thalassemia Minor is related to thrombocytopenia with beta-thalassemia, x-linked and thalassemia. An important gene associated with Thalassemia Minor is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Factors involved in megakaryocyte development and platelet production and African trypanosomiasis. Affiliated tissues include kidney, bone and bone marrow, and related phenotype is integument.

Wikipedia : 73 Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of... more...

Related Diseases for Thalassemia Minor

Diseases related to Thalassemia Minor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia with beta-thalassemia, x-linked 31.9 KLF1 GATA1
2 thalassemia 30.5 LOC107133510 LOC106099062 HBD HBB HBA2 GATA1
3 hypochromic microcytic anemia 30.4 HBB HBA2
4 beta-thalassemia major 30.3 LOC107133510 LOC106099062 HBB
5 hemochromatosis, type 1 30.1 PON1 HBB EPO B2M
6 proteinuria, chronic benign 29.9 COL4A5 B2M
7 beta-thalassemia 29.8 UGT1A1 PON1 LOC107133510 LOC106099062 KLF1 HBD
8 vitamin b12 deficiency 29.7 PON1 EPO
9 alport syndrome 29.6 PKD1 COL4A5 CD151
10 hemoglobin e-beta-thalassemia syndrome 29.5 LOC107133510 LOC106099062 HBB
11 fetal hemoglobin quantitative trait locus 1 29.4 LOC107133510 LOC106099062 HBD HBB
12 hemoglobin h disease 29.2 KLF1 HBD HBB HBA2 EPO
13 methemoglobinemia 29.2 LOC107133510 LOC106099062 HBB HBA2
14 hemolytic anemia 29.0 UGT1A1 LOC107133510 LOC106099062 KLF1 HBB HBA2
15 hemoglobin e disease 29.0 LOC107133510 LOC106099062 KLF1 HBD HBB
16 kidney disease 28.9 PON1 PKD1 EPO COL4A5 B2M
17 deficiency anemia 28.9 PON1 LOC107133510 LOC106099062 KLF1 HBB HBA2
18 polycystic kidney disease 28.8 PKD1 HBA2 EPO COL4A5 B2M
19 hemoglobinopathy 28.7 UGT1A1 LOC107133510 LOC106099062 KLF1 HBD HBB
20 end stage renal disease 28.7 PON1 PKD1 EPO COL4A5 B2M
21 chronic kidney disease 28.7 PON1 PKD1 EPO COL4A5 B2M
22 sickle cell anemia 28.7 UGT1A1 LOC107133510 LOC106099062 HBB HBA2 EPO
23 alpha-thalassemia 28.6 UGT1A1 LOC107133510 LOC106099062 KLF1 HBD HBB
24 malaria 28.6 LOC107133510 LOC106099062 HBB HBA2 EPO B2M
25 sickle cell disease 28.5 UGT1A1 LOC107133510 LOC106099062 HBD HBB HBA2
26 nephropathy with pretibial epidermolysis bullosa and deafness 11.1
27 iron metabolism disease 10.6
28 iron deficiency anemia 10.5
29 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 10.3 KLF1 HBB
30 hemosiderosis 10.2
31 anemia, congenital dyserythropoietic, type iii 10.2 KLF1 GATA1
32 anemia, congenital dyserythropoietic, type ib 10.2 KLF1 GATA1
33 glutathione peroxidase deficiency 10.2 HBB HBA2
34 hemoglobin lepore-beta-thalassemia syndrome 10.2 HBD HBB
35 cutaneous porphyria 10.2 KLF1 GATA1
36 splenic sequestration 10.2 HBB EPO
37 inflammatory bowel disease 27 10.2 GATA1 EPO
38 middle lobe syndrome 10.2 HBD HBB
39 anemia, hypochromic microcytic, with iron overload 1 10.2
40 splenomegaly 10.2
41 rare hereditary hemochromatosis 10.2
42 anemia, congenital dyserythropoietic, type iv 10.2 KLF1 GATA1
43 uremic neuropathy 10.2 EPO B2M
44 spherocytosis, type 2 10.2 KLF1 HBB GATA1
45 spherocytosis, type 4 10.2 KLF1 HBB GATA1
46 spherocytosis, type 3 10.2 KLF1 HBB GATA1
47 microcytic anemia 10.1
48 liver disease 10.1
49 neuropathy, hereditary sensory and autonomic, type iib 10.1 HBD HBB
50 anemia, congenital dyserythropoietic, type ia 10.1 KLF1 GATA1 EPO

Graphical network of the top 20 diseases related to Thalassemia Minor:



Diseases related to Thalassemia Minor

Symptoms & Phenotypes for Thalassemia Minor

MGI Mouse Phenotypes related to Thalassemia Minor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 B2M CD151 EPO GATA1 HBA2 KLF1

Drugs & Therapeutics for Thalassemia Minor

Search Clinical Trials , NIH Clinical Center for Thalassemia Minor

Genetic Tests for Thalassemia Minor

Anatomical Context for Thalassemia Minor

MalaCards organs/tissues related to Thalassemia Minor:

40
Kidney, Bone, Bone Marrow, Liver, Eye, Whole Blood, Nk Cells

Publications for Thalassemia Minor

Articles related to Thalassemia Minor:

(show top 50) (show all 529)
# Title Authors PMID Year
1
β-thalassemia minor is a beneficial determinant of red blood cell storage lesion. 61
33730845 2021
2
Retinal and Choriocapillaris Vascular Changes in Patients Affected by Different Clinical Phenotypes of β-Thalassemia: An Optical Coherence Tomography Angiography Study. 61
33800572 2021
3
Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran. 61
33619933 2021
4
Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome Triggered by COVID-19. 61
33768072 2021
5
Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious. 61
32460294 2021
6
Hemochromatosis in a β-thalassemia minor patient with H63D homozygous mutation: A case report. 61
33363736 2020
7
Lupus erythematosus tumidus in an adolescent with beta thalassemia minor successfully controlled with hydroxychloroquine. 61
33037863 2020
8
Cold Agglutinin Disease and Hemolytic Crisis After Hypothermic Circulatory Arrest in a Patient With Beta-Thalassemia Minor. 61
32245720 2020
9
Septicemic melioidosis complicating undiagnosed chronic kidney disease and beta-thalassemia minor in a Bangladeshi farmer. 61
33565456 2020
10
Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with Beta-Thalassemia Minor for Severe Aplastic Anemia. 61
33020370 2020
11
Determination of mutations in iron regulating genes of beta thalassemia major patients of Khyber Pakhtunkhwa, Pakistan. 61
32588561 2020
12
Letter to the Editor: Portal Vein Thrombosis with Splenic Infarct in β-Thalassemia Minor at High Altitude. 61
32498614 2020
13
Discriminant indexes to simplify the differential diagnosis between iron deficiency anemia and thalassemia minor in individuals with microcytic anemia. 61
33027458 2020
14
The pedigree analysis and prenatal diagnosis of Hong Kongαα Thalassemia and the sequence analysis of Hong Kongαα Allele. 61
32419356 2020
15
Atypical hemolytic uremic syndrome with peripheral gangrene and homocysteinemia in a child. 61
32728451 2020
16
Evaluation of Adipokines Concentration in Iraqi Patients with Major and Minor Beta Thalassemia. 61
33178871 2020
17
The effect of mother's β-thalassemia minor on placental histology and neonatal outcomes. 61
32495664 2020
18
The curious case of hemoglobin DC disease masquerading as sickle cell anemia. 61
32499906 2020
19
Sexual dysfunction in female subjects with beta-thalassemia minor. 61
32341453 2020
20
Antioxidant Activity and Oxidative Stress Status in Maternal Serum of β-thalassemic Mothers Carrying β-thalassemic Major and Normal Fetuses. 61
32064989 2020
21
Prevalence of Congenital Hemolytic Disorders in Denmark, 2000-2016. 61
32547240 2020
22
Coinheritance of beta-thalassemia minor and hereditary pyropoikilocytosis: case report. 61
31080003 2020
23
Common variable immune deficiency, central diabetes insipidus, and anemia. 61
33437189 2020
24
A comparative study of temperamental, behavioral, and cognitive changes in thalassemia major, thalassemia minor, and normal population. 61
31896869 2019
25
Multifactorial Painful Leg Ulcers Due to Hyperhomocysteinemia, Plasminogen Activator Inhibitor-1 4G/5G Heterozygote Gene Mutation, and Beta Thalassemia Minor: A Case Report. 61
31409160 2019
26
Hereditary methemoglobinemia caused by Hb M-Hyde Park (Hb M-Akita) (HBB:c.277C > T; p.His93Tyr). 61
31267164 2019
27
Increased risk of arterial thromboembolic events in transfusion-naïve thalassemia: a nationwide population-based study. 61
31126995 2019
28
Impact of β-thalassemia trait carrier state on inflammatory status in patients with newly diagnosed hypertension. 61
30865135 2019
29
Intraocular pressure in subjects with beta-thalassemia minor. 61
30810618 2019
30
Particular etiology in a case of peripheral tetraparesis. 61
31110746 2019
31
[Epidemiological, clinico-biological, therapeutic and evolutionary aspects of β-thalassemia in Morocco]. 61
30998197 2019
32
Increased Prevalence of Thalassemia in Young People in Korea: Impact of Increasing Immigration. 61
30430775 2019
33
Role of red blood cells "annexin V" and platelets "P-selectin" in patients with thalassemia. 61
30028953 2019
34
[Prevalence and Genetic Analysis of β-Thalassemia in Neonates in Wuhan Area of China]. 61
30738465 2019
35
Prevalence of hemoglobinopathies in the Brazilian adult population: National Health Survey 2014-2015. 61
31596378 2019
36
Investigating the Reliability of HbA1c Monitoring for Blood Glucose Control During Late Pregnancy in Patients with Gestational Diabetes Mellitus (GDM) with and without β-Thalassemia Minor. 61
30284689 2018
37
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters. 61
30184319 2018
38
Glutaric acidemia type II patient with thalassemia minor and novel electron transfer flavoprotein-A gene mutations: A case report and review of literature. 61
30510944 2018
39
Beta-Thalassemia Minor Manifesting as Proliferative Retinopathy. 61
30395680 2018
40
HBG2 -158 (C>T) polymorphism and its contribution to fetal hemoglobin variability in Iraqi Kurds with beta-thalassemia minor. 61
30498305 2018
41
Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor. 61
30483041 2018
42
Raman characterizations of red blood cells with β-thalassemia using laser tweezers Raman spectroscopy. 61
30278579 2018
43
Results of Coexistence of β-Thalassemia Minor in Hb H Disease Patients. 61
30614310 2018
44
β-Thalassemia heterozygote state detrimentally affects health expectation. 61
29934240 2018
45
[Pernicious anemia in a thalassemic patient - difficulties of the diagnosis]. 61
30099903 2018
46
β-Thalassemia intermedia: a comprehensive overview and novel approaches. 61
29380178 2018
47
Should sex differences be considered when applying mathematical indices and formulas for discriminating β- thalassemia minor from iron deficiency? 61
30202778 2018
48
Compound Heterozygosity for Hb D-Ibadan (HBB: c.263C>A) and Hb C (HBB: c.19G>A). 61
30604644 2018
49
Nonischemic Priapism in Childhood: A Case Series and Review of Literature. 61
28346955 2018
50
A KLF1 gene mutation causes β-thalassemia minor in a Chinese family. 61
29393578 2018

Variations for Thalassemia Minor

Expression for Thalassemia Minor

Search GEO for disease gene expression data for Thalassemia Minor.

Pathways for Thalassemia Minor

GO Terms for Thalassemia Minor

Cellular components related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.46 PON1 HBD HBB HBA2
2 endocytic vesicle lumen GO:0071682 9.26 HBB HBA2
3 hemoglobin complex GO:0005833 9.13 HBD HBB HBA2
4 haptoglobin-hemoglobin complex GO:0031838 8.8 HBD HBB HBA2

Biological processes related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.5 HBD HBB GATA1
2 cellular oxidant detoxification GO:0098869 9.43 HBD HBB HBA2
3 acute-phase response GO:0006953 9.37 UGT1A1 EPO
4 erythrocyte differentiation GO:0030218 9.33 KLF1 GATA1 EPO
5 hydrogen peroxide catabolic process GO:0042744 9.13 HBD HBB HBA2
6 oxygen transport GO:0015671 8.8 HBD HBB HBA2

Molecular functions related to Thalassemia Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.58 HBD HBB HBA2
2 peroxidase activity GO:0004601 9.5 HBD HBB HBA2
3 oxygen binding GO:0019825 9.43 HBD HBB HBA2
4 hemoglobin alpha binding GO:0031721 9.37 HBD HBB
5 oxygen carrier activity GO:0005344 9.33 HBD HBB HBA2
6 organic acid binding GO:0043177 9.13 HBD HBB HBA2
7 haptoglobin binding GO:0031720 8.8 HBD HBB HBA2

Sources for Thalassemia Minor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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