MCID: THL003
MIFTS: 28

Thelaziasis

Categories: Eye diseases, Infectious diseases

Aliases & Classifications for Thelaziasis

MalaCards integrated aliases for Thelaziasis:

Name: Thelaziasis 12 15
Infection by Thelazia 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050261
UMLS 70 C0344058

Summaries for Thelaziasis

Disease Ontology : 12 A parasitic helminthiasis infectious diseasea that involves infection of the eyes in humans by nematode Thelazia callipaeda causing varying degrees of inflammation and lacrimation. In heavier infections, photophobia, edema, conjunctivitis, and blindness occurs.

MalaCards based summary : Thelaziasis, also known as infection by thelazia, is related to ophthalmomyiasis and villous adenocarcinoma. An important gene associated with Thelaziasis is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include eye and pancreas.

Wikipedia : 73 Thelaziasis is the term for infestation with parasitic nematodes of the genus Thelazia. The adults of... more...

Related Diseases for Thelaziasis

Diseases related to Thelaziasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 ophthalmomyiasis 29.7 MT-CYB MT-CO1
2 villous adenocarcinoma 10.3 MT-ND6 MT-ATP8
3 echinostomiasis 10.2 MT-ND4L MT-CO1
4 conjunctivitis 10.2
5 cercarial dermatitis 10.2 MT-CO1 MT-ATP8
6 parkinson disease 6, autosomal recessive early-onset 10.2 MT-ND6 MT-ND5
7 drug-induced hearing loss 10.2 UCN MT-ND6
8 periodic paralysis with later-onset distal motor neuropathy 10.1 MT-ATP8 MT-ATP6
9 dirofilariasis 10.1 PTGS1 MT-CO1
10 coenurosis 10.1 MT-ND1 MT-CO1
11 intracranial vasospasm 10.1 MT-ND5 MT-ATP6
12 isolated atp synthase deficiency 10.1 MT-ATP8 MT-ATP6
13 polycystic echinococcosis 10.1 MT-ND1 MT-CO1
14 retinal detachment 10.0
15 allergic conjunctivitis 10.0
16 progressive myoclonus epilepsy 8 10.0 MT-ND5 MT-ND4L MT-ND2
17 neuropathy, ataxia, and retinitis pigmentosa 10.0 MT-ND6 MT-ATP8 MT-ATP6
18 cardiomyopathy, infantile hypertrophic 10.0 MT-ND6 MT-ATP8 MT-ATP6
19 alzheimer disease mitochondrial 10.0 MT-ND2 MT-ND1
20 oesophagostomiasis 10.0 MT-CYB MT-CO1
21 cortical blindness 10.0 MT-ND6 MT-ND5 MT-ND1
22 early myoclonic encephalopathy 10.0 MT-ND6 MT-ND5 MT-ATP6
23 leber optic atrophy and dystonia 9.9 MT-ND6 MT-ND3 MT-ND1
24 pediculus humanus corporis infestation 9.9 MT-CYB MT-CO1
25 deafness, nonsyndromic sensorineural, mitochondrial 9.9 MT-ND1 MT-CO1
26 bartonellosis 9.9 MT-CYB MT-CO1
27 disease by infectious agent 9.9
28 filariasis 9.9
29 corneal abscess 9.9
30 giant papillary conjunctivitis 9.9
31 papillary conjunctivitis 9.9
32 eye disease 9.9
33 cataract 9.9
34 severe congenital neutropenia 1 9.8 MT-ND5 MT-ND2 MT-ND1
35 babesiosis 9.8 MT-CYB MT-CO1
36 cysticercosis 9.8 MT-ND1 MT-CO1
37 cystic echinococcosis 9.8 MT-ND1 MT-CO1 MT-ATP6
38 echinococcosis 9.8 MT-ND1 MT-CO1 MT-ATP6
39 familial colorectal cancer 9.8 MT-ND4L MT-CYB MT-CO1
40 amelogenesis imperfecta, type iv 9.8 MT-CYB MT-CO1
41 deafness, aminoglycoside-induced 9.8 UCN MT-ND6 MT-ND1 MT-CO1
42 mitochondrial dna depletion syndrome 4a 9.8 MT-ND5 MT-ND1 MT-ATP6
43 pearson marrow-pancreas syndrome 9.8 MT-ND6 MT-CYB MT-ATP6
44 diphyllobothriasis 9.7 MT-ND5 MT-ND3 MT-ND1 MT-CO1
45 myasthenic syndrome, congenital, 10 9.7 MT-ND2 MT-CYB MT-CO1
46 mitochondrial complex iv deficiency, nuclear type 5 9.7 MT-ND6 MT-CYB MT-ATP6
47 endometrial stromal tumor 9.7 MT-ND2 MT-CYB MT-CO1
48 mental retardation, autosomal dominant 30 9.7 MT-CYB MT-ATP8
49 fascioliasis 9.7 MT-ND1 MT-CO1
50 cardiomyopathy, infantile histiocytoid 9.7 MT-CYB MT-ATP8 MT-ATP6

Graphical network of the top 20 diseases related to Thelaziasis:



Diseases related to Thelaziasis

Symptoms & Phenotypes for Thelaziasis

Drugs & Therapeutics for Thelaziasis

Search Clinical Trials , NIH Clinical Center for Thelaziasis

Genetic Tests for Thelaziasis

Anatomical Context for Thelaziasis

MalaCards organs/tissues related to Thelaziasis:

40
Eye, Pancreas

Publications for Thelaziasis

Articles related to Thelaziasis:

(show top 50) (show all 81)
# Title Authors PMID Year
1
A Case of Human Thelaziasis and Review of Chinese Cases. 61
32144548 2020
2
Phthiriasis palpebrarum, thelaziasis, and ophthalmomyiasis. 61
32447120 2020
3
Thelaziasis as an uncommon cause of giant papillary conjunctivitis. 61
32586115 2020
4
[Screening and bioinformatic analysis of trehalase in Thelazia callipaeda]. 61
32185929 2020
5
First report of eyeworm infection by Thelazia callipaeda in gray wolf (Canis lupus) from Serbia. 61
31722066 2019
6
Periocular thelaziasis presenting as an orbital mass - a case report. 61
30668201 2019
7
[Advances in etiology, epidemiology and genetic diversity of Thelazia callipaeda]. 61
31016929 2019
8
Human ocular thelaziasis caused by gravid Thelazia callipaeda - A unique and rare case report. 61
30672496 2019
9
[Human thelaziasis callipaeda in Tongren area of Guizhou Province: a case report]. 61
31184066 2018
10
Human Thelaziasis: Emerging Ocular Pathogen in Nepal. 61
30349847 2018
11
Live encysted Thelazia callipaeda presenting as a lump adjacent to the right lacrimal sac in a 42-year-old female: A rare case report. 61
30038190 2018
12
Ocular thelaziasis: A case report from Assam, India. 61
30693214 2018
13
Case Report: Conjunctival Infestation with Thelazia gulosa: A Novel Agent of Human Thelaziasis in the United States. 61
29436343 2018
14
Population structure analysis of the neglected parasite Thelazia callipaeda revealed high genetic diversity in Eastern Asia isolates. 61
29324738 2018
15
Thelazia callipaeda infection in a 5-month-old infant. 61
28710682 2017
16
[Genetic variation of Thelazia callipaeda among isolates collected from patients in Zunyi City, Guizhou Province]. 61
29469356 2017
17
Morphological and Mitochondrial Genomic Characterization of Eyeworms (Thelazia callipaeda) from Clinical Cases in Central China. 61
28751889 2017
18
A Pediatric Case of Thelaziasis in Korea. 61
27417087 2016
19
Human ocular thelaziasis: a case report from Karnataka. 61
25866001 2015
20
Human ocular thelaziasis in Karnataka. 61
25827555 2015
21
[THE FIRST CASE OF OCULAR THELAZIASIS IN CROATIA]. 61
29087095 2015
22
Two cases of human thelaziasis as confirmed by mitochondrial cox1 sequencing in China. 61
25253041 2014
23
Human ocular thelaziasis in Karnataka. 61
25116781 2014
24
Parasitic infections based on 320 clinical samples submitted to Hanyang University, Korea (2004-2011). 61
24850969 2014
25
Ocular thelaziasis in a 7-month-old infant. 61
24399399 2014
26
Thelazia callipaeda: a human case report. 61
23077806 2012
27
Two cases of human thelaziasis and brief review of Korean cases. 61
22072826 2011
28
Thelazia rhodesii in the African buffalo, Syncerus caffer, in Zambia. 61
21461276 2011
29
Zoonotic helminths affecting the human eye. 61
21429191 2011
30
Human thelaziasis in Bangladesh. 61
21240176 2011
31
Ocular thelaziosis in dogs, France. 61
21122226 2010
32
A case of intraocular thelaziasis with rhegmatogenous retinal detachment. 61
20629668 2010
33
[Two cases of thelaziasis]. 61
21137311 2010
34
Analysis of parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (1984-2005) in Seoul, Korea. 61
20333293 2010
35
Human thelaziasis, Europe. 61
18394285 2008
36
[Ocular thelaziasis in man in Northern Italy]. 61
18431997 2008
37
Ocular thelaziasis in Assam: a report of two cases. 61
18417889 2008
38
First reports of autochthonous eyeworm infection by Thelazia callipaeda (Spirurida, Thelaziidae) in dogs and cat from France. 61
17854998 2007
39
Morphological differentiation among three Thelazia species (Nematoda: Thelaziidae) by scanning electron microscopy. 61
17211660 2007
40
Human thelaziasis in India. 61
17377361 2007
41
A case of human thelaziasis from Himachal Pradesh. 61
16505563 2006
42
Human Thelaziasis occurrence in Taiwan. 61
16430440 2006
43
[Longitudinal investigation and experimental studies on thelaziasis and the intermediate host of Thelazia callipaeda in Guanghua county of Hubei province]. 61
12975015 2003
44
Five cases of thelaziasis. 61
10777285 2000
45
Two human cases of Thelazia callipaeda infection in Korea. 61
7551806 1995
46
Thelaziasis: report of two cases. 61
8025054 1993
47
[Parasitic zoonoses in Japan, with special reference to the current topics]. 61
2513435 1989
48
Scanning electron microscopic observations of Thelazia callipaeda from human. 61
2486933 1989
49
Ocular thelaziasis in Thailand: a case report. 61
2809450 1989
50
First case of human Thelaziasis in Indonesia. 61
2609214 1989

Variations for Thelaziasis

Expression for Thelaziasis

Search GEO for disease gene expression data for Thelaziasis.

Pathways for Thelaziasis

GO Terms for Thelaziasis

Cellular components related to Thelaziasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 10 MT-ND6 MT-ND5 MT-ND4L MT-ND3 MT-ND2 MT-ND1
2 mitochondrial membrane GO:0031966 9.72 MT-ND6 MT-ND4L MT-ND3 MT-ND1 MT-ATP8
3 mitochondrial inner membrane GO:0005743 9.61 MT-ND6 MT-ND5 MT-ND3 MT-ND2 MT-ND1 MT-CYB
4 mitochondrial respiratory chain complex I GO:0005747 9.55 MT-ND5 MT-ND4L MT-ND3 MT-ND2 MT-ND1
5 mitochondrial proton-transporting ATP synthase complex GO:0005753 9.48 MT-ATP8 MT-ATP6
6 proton-transporting ATP synthase complex, coupling factor F(o) GO:0045263 9.46 MT-ATP8 MT-ATP6
7 mitochondrial respiratory chain complex III GO:0005750 9.43 MT-CYB MT-CO1
8 CCAAT-binding factor complex GO:0016602 9.4 NFYC NFYB
9 NADH dehydrogenase complex GO:0030964 9.37 MT-ND4L MT-ND3
10 respiratory chain GO:0070469 9.23 MT-ND6 MT-ND5 MT-ND4L MT-ND3 MT-ND2 MT-ND1

Biological processes related to Thelaziasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.67 UCN PTGS1 MT-ND3 MT-CO1
2 oxidation-reduction process GO:0055114 9.61 PTGS1 MT-ND6 MT-ND5 MT-ND4L MT-ND3 MT-ND2
3 mitochondrial respiratory chain complex I assembly GO:0032981 9.55 MT-ND6 MT-ND5 MT-ND3 MT-ND2 MT-ND1
4 ATP biosynthetic process GO:0006754 9.54 MT-ATP8 MT-ATP6
5 cristae formation GO:0042407 9.52 MT-ATP8 MT-ATP6
6 ATP synthesis coupled proton transport GO:0015986 9.51 MT-ATP8 MT-ATP6
7 aerobic respiration GO:0009060 9.5 UCN MT-ND1 MT-CO1
8 mitochondrial ATP synthesis coupled proton transport GO:0042776 9.49 MT-ATP8 MT-ATP6
9 respiratory electron transport chain GO:0022904 9.48 MT-CYB MT-CO1
10 response to copper ion GO:0046688 9.46 MT-CYB MT-CO1
11 response to hyperoxia GO:0055093 9.43 MT-CYB MT-ATP6
12 electron transport coupled proton transport GO:0015990 9.43 MT-ND5 MT-CYB MT-CO1
13 ATP synthesis coupled electron transport GO:0042773 9.4 MT-ND5 MT-ND4L
14 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.1 MT-ND6 MT-ND5 MT-ND4L MT-ND3 MT-ND2 MT-ND1

Molecular functions related to Thelaziasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proton transmembrane transporter activity GO:0015078 9.26 MT-ATP8 MT-ATP6
2 proton-transporting ATP synthase activity, rotational mechanism GO:0046933 9.16 MT-ATP8 MT-ATP6
3 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.1 MT-ND6 MT-ND5 MT-ND4L MT-ND3 MT-ND2 MT-ND1
4 NADH dehydrogenase activity GO:0003954 8.96 MT-ND5 MT-ND1

Sources for Thelaziasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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