1 |
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
62
57
5
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Krynetski EY...Evans WE
|
7862671 |
1995 |
2 |
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia.
62
57
5
|
Evans WE...Roberts WM
|
1960624 |
1991 |
3 |
Severe azathioprine-induced myelotoxicity in a kidney transplant patient with thiopurine S-methyltransferase-deficient genotype (TPMT*3A/*3C).
57
5
|
Kurzawski M...Drozdzik M
|
15819814 |
2005 |
4 |
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.
62
57
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Schwab M...Kaskas BA
|
12172211 |
2002 |
5 |
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
62
57
|
Evans WE...Relling MV
|
11304783 |
2001 |
6 |
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.
62
5
|
Tai HL...Evans WE
|
9177237 |
1997 |
7 |
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
62
5
|
Tai HL...Evans WE
|
8644731 |
1996 |
8 |
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.
62
57
|
Lennard L...Lilleyman JS
|
8257179 |
1993 |
9 |
Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.
5
|
Lindqvist M...Almer S
|
17885628 |
2007 |
10 |
Molecular analysis of thiopurine S-methyltransferase alleles in Taiwan aborigines and Taiwanese.
5
|
Lu HF...Chang JG
|
16476125 |
2006 |
11 |
The thiopurines: an update.
57
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Coulthard S...Hogarth L
|
16267626 |
2005 |
12 |
Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation.
5
|
Wang L...Weinshilboum RM
|
15967990 |
2005 |
13 |
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
57
|
Stanulla M...Schwab M
|
15784872 |
2005 |
14 |
Thiopurine S-methyltransferase: a genetic polymorphism that affects a small number of drugs in a big way.
57
|
Evans WE
|
12172209 |
2002 |
15 |
Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population.
5
|
Hiratsuka M...Mizugaki M
|
10751626 |
2000 |
16 |
Thiopurine methyltransferase pharmacogenetics: alternative molecular diagnosis and preliminary data from Northern Portugal.
57
|
Alves S...Amorim A
|
10376773 |
1999 |
17 |
The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations.
5
|
Collie-Duguid ES...McLeod HL
|
10208641 |
1999 |
18 |
Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.
5
|
Hon YY...Evans WE
|
9931346 |
1999 |
19 |
Thiopurine methyltransferase alleles in British and Ghanaian populations.
5
|
Ameyaw MM...McLeod HL
|
9931345 |
1999 |
20 |
Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine.
57
|
Black AJ...Reid DM
|
9841604 |
1998 |
21 |
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.
5
|
Leipold G...Oellerich M
|
9336428 |
1997 |
22 |
Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.
5
|
Otterness D...Weinshilboum R
|
9246020 |
1997 |
23 |
Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism.
5
|
Szumlanski C...Weinshilboum R
|
8561894 |
1996 |
24 |
The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts.
57
|
Vogt MH...Trijbels FJ
|
7683208 |
1993 |
25 |
Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.
57
|
Schutz E...Oellerich M
|
8094196 |
1993 |
26 |
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia.
57
|
Lennard L...Weinshilboum RM
|
1973780 |
1990 |
27 |
Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism.
57
|
Lennard L...Weinshilboum RM
|
2758725 |
1989 |
28 |
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations.
57
|
Lennard L...Weinshilboum RM
|
3467886 |
1987 |
29 |
Case Report: Multifocal EBV-Associated Diffuse Large B-Cell Lymphoma in a Patient With 6-MP Associated Lymphopenia With TPMT Deficiency.
62
|
Muller-Scholden L...Wolfl M
|
35601437 |
2022 |
30 |
Cost-effectiveness analysis of genotype screening and therapeutic drug monitoring in patients with inflammatory bowel disease treated with azathioprine therapy: a Chinese healthcare perspective using real-world data.
62
|
Zeng D...Huang P
|
34430579 |
2021 |
31 |
Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.
62
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Zhou Y...Lauschke VM
|
32973300 |
2020 |
32 |
Reducing risk in thiopurine therapy.
62
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Marinaki AM...Arenas-Hernandez M
|
31682552 |
2020 |
33 |
Severe pancytopenia and aspergillosis caused by thioguanine in a thiopurine S-methyltransferase deficient patient: a case report.
62
|
de Hoogd S...Harmsze AM
|
31464791 |
2019 |
34 |
Modeling the Outcome of Systematic TPMT Genotyping or Phenotyping Before Azathioprine Prescription: A Cost-Effectiveness Analysis.
62
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Zarca K...Pallet N
|
30963516 |
2019 |
35 |
Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.
62
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Tsujimoto S...Kato M
|
29967377 |
2018 |
36 |
Analytical and clinical validation of an LC-MS/MS method to measure thiopurine S-methyltransferase activity by quantifying d3-6-MMP.
62
|
Ma J...Pike LS
|
29425801 |
2018 |
37 |
Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.
62
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Liu C...Relling MV
|
28623449 |
2017 |
38 |
Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease.
62
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Wong DR...TOPIC recruitment team
|
27402913 |
2017 |
39 |
Azathioprine Therapy in a Pediatric TPMT-Deficient Patient-Still an Option.
62
|
van Moorsel SA...Wong DR
|
28081040 |
2017 |
40 |
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.
62
|
Man SC...Gheban D
|
28523321 |
2017 |
41 |
A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs.
62
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Skrzypczak-Zielinska M...Slomski R
|
27307154 |
2016 |
42 |
Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy.
62
|
Zur RM...Ungar WJ
|
27217052 |
2016 |
43 |
Pharmacogenomics for leukemia treatment.
62
|
Tanaka Y
|
27498738 |
2016 |
44 |
The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone.
62
|
O'Donnell PH...Ratain MJ
|
26756170 |
2016 |
45 |
Update on thiopurine pharmacogenetics in inflammatory bowel disease.
62
|
Roberts RL...Barclay ML
|
26067482 |
2015 |
46 |
Implementation of TPMT testing.
62
|
Lennard L
|
23962279 |
2014 |
47 |
High-resolution melting analysis of the TPMT gene: a study in the Polish population.
62
|
Skrzypczak-Zielinska M...Slomski R
|
23252704 |
2013 |
48 |
Let's get personal: predicting thiopurine and fluoropyrimidine toxicity.
62
|
Corrigan A...Marinaki A
|
29776234 |
2012 |
49 |
Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease.
62
|
Roberts RL...Barclay ML
|
22741564 |
2012 |
50 |
Establishment of thiopurine S-methyltransferase gene knockdown in jurkat T-lymphocytes: an in vitro model of TPMT polymorphism.
62
|
Misdaq M...von Ahsen N
|
22972540 |
2012 |