Aliases & Classifications for Thiourea Tasting

MalaCards integrated aliases for Thiourea Tasting:

Name: Thiourea Tasting 57 29
Phenylthiocarbamide Tasting 57 6
Thiot 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant
possibly two loci involved


HPO:

32
thiourea tasting:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 171200
MedGen 42 C1868397
SNOMED-CT via HPO 69 263681008 362969004

Summaries for Thiourea Tasting

OMIM : 57 The sense of bitter taste is mediated by a group of bitter taste receptor proteins that reside on the surface of taste cells within the taste buds of the tongue. These proteins are 7-transmembrane domain, G protein-coupled receptors that are encoded by the TAS2R gene family (see TAS2R10; 604791), which contains at least 25 functional genes (Kim et al., 2005). Humans worldwide display a bimodality in sensitivity to the bitter taste of PTC, with approximately 75% of individuals perceiving it as intensely bitter, whereas the rest perceive it as tasteless. This difference has been the basis of study of taste perception in humans for over 70 years. Kim and Drayna (2004) provided an historical review of the subject. Propylthiouracil (PROP) and PTC are members of a class of compounds known as thioureas. The compounds carry the chemical group N-C=S, which is responsible for their characteristic bitter taste (Bartoshuk et al., 1994; Drewnowski and Rock, 1995). (171200)

MalaCards based summary : Thiourea Tasting, also known as phenylthiocarbamide tasting, is related to motion sickness and schizophrenia. An important gene associated with Thiourea Tasting is TAS2R38 (Taste 2 Receptor Member 38). Affiliated tissues include tongue, and related phenotype is abnormality of the endocrine system.

Related Diseases for Thiourea Tasting

Diseases related to Thiourea Tasting via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 motion sickness 10.2
2 schizophrenia 10.0
3 peptic ulcer disease 10.0
4 depression 10.0

Symptoms & Phenotypes for Thiourea Tasting

Symptoms via clinical synopsis from OMIM:

57
Endocrine:
relationship between ptc nontasting to cretinism

Misc:
variation in ability to taste ptc


Clinical features from OMIM:

171200

Human phenotypes related to Thiourea Tasting:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the endocrine system 32 HP:0000818

Drugs & Therapeutics for Thiourea Tasting

Search Clinical Trials , NIH Clinical Center for Thiourea Tasting

Genetic Tests for Thiourea Tasting

Genetic tests related to Thiourea Tasting:

# Genetic test Affiliating Genes
1 Thiourea Tasting 29 TAS2R38

Anatomical Context for Thiourea Tasting

MalaCards organs/tissues related to Thiourea Tasting:

41
Tongue

Publications for Thiourea Tasting

Articles related to Thiourea Tasting:

(show all 12)
# Title Authors Year
1
Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q. ( 22955840 )
2012
2
Phenylthiocarbamide taste perception and susceptibility to motion sickness: linking higher susceptibility with higher phenylthiocarbamide taste acuity. ( 18252010 )
2008
3
Associations of phenylthiocarbamide tasting to alcohol problems and family history of alcoholism differ by gender. ( 16712955 )
2006
4
Phenylthiocarbamide tasting and family history of depression, revisited: low rates of depression in families of supertasters. ( 15081630 )
2004
5
Phenylthiocarbamide taste sensitivity in chronic peptic ulcer. ( 2344942 )
1990
6
Phenylthiocarbamide tasting in a sample of twins. ( 1169903 )
1975
7
Relation between some forms of glaucoma and phenylthiocarbamide tasting. ( 4725858 )
1973
8
Phenylthiocarbamide tasting ability among Lapps and Finns. ( 5514301 )
1970
9
Phenylthiocarbamide tasting ability and malignant tumours. ( 5366287 )
1969
10
Evidence against the reported linkage of phosphoglucomutase (PGM) and phenylthiocarbamide-tasting (PTC). ( 5756058 )
1968
11
PHENYLTHIOCARBAMIDE-TASTING IN THE MENTALLY IMMATURE. ( 14288581 )
1965
12
Distribution of phenylthiocarbamide tasting phenotypes in students with different ancestry in Santiago, Chile. ( 5825761 )
1964

Variations for Thiourea Tasting

ClinVar genetic disease variations for Thiourea Tasting:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TAS2R38 NM_176817.4(TAS2R38): c.145G> C (p.Ala49Pro) single nucleotide variant drug response rs713598 GRCh37 Chromosome 7, 141673345: 141673345
2 TAS2R38 NM_176817.4(TAS2R38): c.145G> C (p.Ala49Pro) single nucleotide variant drug response rs713598 GRCh38 Chromosome 7, 141973545: 141973545
3 TAS2R38 NM_176817.4(TAS2R38): c.785T> C (p.Val262Ala) single nucleotide variant drug response rs1726866 GRCh37 Chromosome 7, 141672705: 141672705
4 TAS2R38 NM_176817.4(TAS2R38): c.785T> C (p.Val262Ala) single nucleotide variant drug response rs1726866 GRCh38 Chromosome 7, 141972905: 141972905
5 TAS2R38 NM_176817.4(TAS2R38): c.886A> G (p.Ile296Val) single nucleotide variant drug response rs10246939 GRCh37 Chromosome 7, 141672604: 141672604
6 TAS2R38 NM_176817.4(TAS2R38): c.886A> G (p.Ile296Val) single nucleotide variant drug response rs10246939 GRCh38 Chromosome 7, 141972804: 141972804

Expression for Thiourea Tasting

Search GEO for disease gene expression data for Thiourea Tasting.

Pathways for Thiourea Tasting

GO Terms for Thiourea Tasting

Sources for Thiourea Tasting

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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