MCID: THR010
MIFTS: 23

Third Cranial Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Third Cranial Nerve Disease

MalaCards integrated aliases for Third Cranial Nerve Disease:

Name: Third Cranial Nerve Disease 12 15
Disorder of Oculomotor Nerve 12
Third Cranial Nerve Disorder 71
Oculomotor Nerve Paralysis 71
Oculomotor Nerve Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:562
NCIt 49 C27598
SNOMED-CT 67 60750009
UMLS 71 C0028866 C0271353

Summaries for Third Cranial Nerve Disease

MalaCards based summary : Third Cranial Nerve Disease, also known as disorder of oculomotor nerve, is related to oculomotor nerve paralysis and rare oculomotor nerve disorder, and has symptoms including ophthalmoparesis, ophthalmoplegia and setting-sun eye phenomenon. An important gene associated with Third Cranial Nerve Disease is NT5C3A (5'-Nucleotidase, Cytosolic IIIA), and among its related pathways/superpathways is Type I Interferon Signaling Pathways. Affiliated tissues include eye, pituitary and brain.

Wikipedia : 74 The oculomotor nerve is the third cranial nerve (CN III). It enters the orbit via the superior orbital... more...

Related Diseases for Third Cranial Nerve Disease

Diseases related to Third Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 oculomotor nerve paralysis 26.5 ZFHX4 PNMA2 NT5C3A MTRNR2L4 IFNA2 COLQ
2 rare oculomotor nerve disorder 12.4
3 facial paralysis 10.0 NT5C3A MTRNR2L4
4 horner's syndrome 10.0 ZFHX4 NT5C3A
5 facial nerve disease 9.9 NT5C3A MTRNR2L4
6 systemic lupus erythematosus 9.9
7 peripheral nervous system disease 9.9
8 neuropathy 9.9
9 lupus erythematosus 9.9
10 congenital ptosis 9.8 ZFHX4 NT5C3A
11 duane retraction syndrome 9.6 ZFHX4 NT5C3A
12 ptosis 9.2 ZFHX4 NT5C3A COLQ

Graphical network of the top 20 diseases related to Third Cranial Nerve Disease:



Diseases related to Third Cranial Nerve Disease

Symptoms & Phenotypes for Third Cranial Nerve Disease

UMLS symptoms related to Third Cranial Nerve Disease:


ophthalmoparesis, ophthalmoplegia, setting-sun eye phenomenon

Drugs & Therapeutics for Third Cranial Nerve Disease

Search Clinical Trials , NIH Clinical Center for Third Cranial Nerve Disease

Genetic Tests for Third Cranial Nerve Disease

Anatomical Context for Third Cranial Nerve Disease

MalaCards organs/tissues related to Third Cranial Nerve Disease:

40
Eye, Pituitary, Brain, Tonsil

Publications for Third Cranial Nerve Disease

Articles related to Third Cranial Nerve Disease:

(show top 50) (show all 69)
# Title Authors PMID Year
1
The aetiologies of unilateral oculomotor nerve palsy: a clinical analysis on 121 patients. 61
31035834 2019
2
Oculomotor Nerve Palsy Associated with Duplication of Middle Cerebral Artery, Anterior Communicating Artery Aneurysm, and Parietal Meningioma. 61
30723526 2019
3
Monocular Oculomotor Nerve Disorder Manifesting as Cranial Neuropathy in Systemic Lupus Erythematosus. 61
29984768 2018
4
[One case of oculomotor nerve paralysis caused by chronic ethmoidal sinusitis]. 61
30453409 2018
5
Conservative treatment cures an elderly pituitary apoplexy patient with oculomotor paralysis and optic nerve compression: a case report and systematic review of the literature. 61
30349217 2018
6
Skull base chondrosarcoma radiosurgery: report of the North American Gamma Knife Consortium. 61
26115468 2015
7
A Rare Cause of Sudden Ptosis: Posterior Communicating Artery Aneurysm. 61
27336071 2015
8
Primary sphenoid sinus meningioma resection via transnasal transsphenoid approach: a case report. 61
25681214 2015
9
[Acupuncture mainly at Yuyao (EX-HN 4) and Shangjingming (Extra) for 35 cases of oculomotor nerve paralysis]. 61
25854031 2015
10
[Factors affecting oculomotor nerve function recovery time following balloon embolization for oculomotor nerve palsy caused by traumatic carotid cavernous sinus fistula]. 61
25736121 2015
11
Tolosa-hunt syndrome in double-hit lymphoma. 61
25918657 2015
12
Resection of an oculomotor nerve cavernous angioma. 61
25184101 2014
13
Ethmoidal mucocele presenting as oculomotor nerve paralysis. 61
23799169 2013
14
Neurobrucellosis developing unilateral oculomotor nerve paralysis. 61
22244219 2012
15
Microsurgical Relations between Internal Carotid Artery-Posterior Communicating Artery (ICA-PComA) Segment Aneurysms and Skull Base: An Anatomoclinical Study. 61
24083126 2012
16
[Nasal polyps in ethmoid and sphenoid sinus with oculomotor nerve paralysis: a case report]. 61
22088291 2011
17
Effective acupuncture practice through diagnosis based on distribution of meridian pathways & related syndromes. 61
21830349 2011
18
Diagnosis and microsurgical treatment of cavernous sinus hemangioma. 61
20196684 2010
19
[Ocular manifestations of brainstem tumor]. 61
20137418 2009
20
Unilateral oculomotor nerve palsy: unusual sign of hydrocephalus. 61
19546847 2009
21
Unilateral isolated partial oculomotor nerve paralysis after percutaneous intervention. 61
19054794 2009
22
Asymmetric FDG uptake in the extraocular muscles resulting from oculomotor nerve paralysis. 61
19387218 2009
23
[Neurological manifestations of Behcet's disease: 22 cases among 170 patients]. 61
19062244 2009
24
[Paraneoplastic limbic encephalitis with positive anti-RI antibodies and mediastinal seminoma]. 61
18565362 2008
25
Transient isolated oculomotor nerve paralysis in neonatal group B streptococcal meningitis. 61
18377371 2008
26
Surgical management of large-angle incomitant strabismus in patients with oculomotor nerve palsy. 61
18029212 2008
27
[Surgical treatment of lateral sellar compartment cavernoma]. 61
17650393 2007
28
[Endoscopic surgical treatment of patients with isolated sphenoid sinus disease]. 61
17847777 2007
29
Primary germinoma arising from the midbrain. 61
17039305 2006
30
[Diagnosis and therapy of intracavernosal cavernous hemangioma]. 61
15730622 2004
31
Gliomatosis cerebri in a young patient showing various cranial nerve manifestations: a case report. 61
14756448 2003
32
[Oculomotor nerve paralysis and purulent acute tonsillitis. A case report]. 61
12022085 2002
33
[Detection of brain vascular diseases with CT angiography]. 61
12536503 2001
34
Immature teratoma originating from the pituitary gland: case report. 61
10069602 1999
35
Probable lymphocytic hypophysitis diagnosed by short-term serial computed tomography and gallium-67 scintigraphy--case report. 61
10193154 1999
36
Möbius syndrome with oculomotor nerve paralysis without abducens paralysis. 61
9858013 1998
37
[A case of early-onset acute disseminated encephalomyelitis]. 61
9294316 1997
38
Isolated oculomotor nerve paralysis in Lyme disease: MRI. 61
9045977 1997
39
[Oculomotor nerve paralysis with complete ptosis in herpes zoster ophthalmicus: 2 cases]. 61
9739899 1997
40
[A case of meningo-vascular type neurosyphilis presenting oculomotor nerve paralysis with interesting MRI findings]. 61
7561375 1995
41
Clinical toxicity of the interferons. 61
7516663 1994
42
[Oculomotor nerve paralysis in patients with rheumatic disease, possible causes and anatomical localization of the lesions]. 61
8447004 1993
43
[Oculomotor nerve paralysis, a symptom of an aneurysm of the posterior communicating artery]. 61
1525148 1992
44
Bilateral oculomotor nerve palsies due to posterior cerebral arterial compression relieved by microvascular decompression--case report. 61
1712923 1991
45
Crossed innervation of the superior rectus. 61
1660374 1991
46
[Value of clinical diagnosis of internuclear oculomotor nerve paralysis for determining the focus of damage and symptomatology of exacerbation of chronic neurologic infection]. 61
1647626 1991
47
Reversible nuclear oculomotor nerve paralysis. Caused by a primary mesencephalic hemorrhage. 61
2358005 1990
48
Oculomotor nerve paralysis induced by alpha II-interferon. 61
2114727 1990
49
[Oculomotor nerve paralysis secondary to dural carotido-cavernous sinus fistula]. 61
2641090 1989
50
[Oculomotor nerve paralysis in intracranial aneurysm]. 61
3268735 1988

Variations for Third Cranial Nerve Disease

Expression for Third Cranial Nerve Disease

Search GEO for disease gene expression data for Third Cranial Nerve Disease.

Pathways for Third Cranial Nerve Disease

Pathways related to Third Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.93 IFNA2 ARHGEF1

GO Terms for Third Cranial Nerve Disease

Biological processes related to Third Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 8.62 NT5C3A IFNA2

Sources for Third Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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