MCID: THR010
MIFTS: 27

Third Cranial Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Third Cranial Nerve Disease

MalaCards integrated aliases for Third Cranial Nerve Disease:

Name: Third Cranial Nerve Disease 12 15
Disorder of Oculomotor Nerve 12
Third Cranial Nerve Disorder 74
Oculomotor Nerve Paralysis 74
Oculomotor Nerve Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:562
NCIt 51 C27598
SNOMED-CT 69 60750009

Summaries for Third Cranial Nerve Disease

MalaCards based summary : Third Cranial Nerve Disease, also known as disorder of oculomotor nerve, is related to facial hemiatrophy and plexopathy, and has symptoms including ophthalmoparesis, ophthalmoplegia and setting-sun eye phenomenon. An important gene associated with Third Cranial Nerve Disease is ARHGEF1 (Rho Guanine Nucleotide Exchange Factor 1). The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include eye and brain.

Related Diseases for Third Cranial Nerve Disease

Diseases related to Third Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 facial hemiatrophy 10.2 ARHGEF1 KANTR
2 plexopathy 10.2 AVP CAMP
3 anal spasm 10.2 CAMP KANTR
4 central pontine myelinolysis 10.2 AVP MBP
5 paraphimosis 10.1 CAMP KANTR
6 brain germinoma 10.1 AFP AVP
7 tuberculous epididymitis 10.1 AFP AVP
8 central nervous system germ cell tumor 10.1 AFP AVP
9 anismus 10.1 CAMP KANTR
10 cranial nerve disease 10.1 KANTR MBP
11 malignant teratoma 10.1 AFP AVP
12 dental abscess 10.1 AVP KANTR
13 sphenoid sinusitis 10.1 AVP KANTR
14 alexia 10.1 KANTR MBP
15 dystonia 1, torsion, autosomal dominant 10.1 CAMP KANTR
16 granulomatous angiitis 10.1 AVP MBP
17 tabes dorsalis 10.1 KANTR MBP
18 anterior spinal artery syndrome 10.1 KANTR MBP
19 internuclear ophthalmoplegia 10.0 KANTR MBP
20 hemidystonia 10.0 CAMP KANTR
21 carotid artery dissection 9.9 AVP KANTR
22 tertiary neurosyphilis 9.9 KANTR MBP
23 cloacal exstrophy 9.9 AFP KANTR
24 premenstrual tension 9.9 AVP CAMP KANTR
25 tracheal cancer 9.9 AFP AVP
26 systemic lupus erythematosus 9.9
27 neuropathy 9.9
28 lupus erythematosus 9.9
29 lateral medullary syndrome 9.8 KANTR PNMA2
30 peripheral nervous system disease 9.8 KANTR MBP
31 branch retinal artery occlusion 9.8 KANTR PNMA2
32 peliosis hepatis 9.8 AFP PNMA2
33 nervous system disease 9.7 KANTR MBP
34 agraphia 9.6 KANTR MBP PNMA2
35 oculomotor nerve paralysis 8.3 AFP ARHGEF1 AVP CAMP KANTR MBP

Graphical network of the top 20 diseases related to Third Cranial Nerve Disease:



Diseases related to Third Cranial Nerve Disease

Symptoms & Phenotypes for Third Cranial Nerve Disease

UMLS symptoms related to Third Cranial Nerve Disease:


ophthalmoparesis, ophthalmoplegia, setting-sun eye phenomenon

Drugs & Therapeutics for Third Cranial Nerve Disease

Drugs for Third Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Ocular Electroacupuncture on Oculomotor Nerve Palsy Recruiting NCT03099447 Not Applicable
2 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
3 A Real-time Magnetic Device Prototype for Temporary Management of Blepharoptosis Recruiting NCT03812016 Not Applicable
4 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Third Cranial Nerve Disease

Genetic Tests for Third Cranial Nerve Disease

Anatomical Context for Third Cranial Nerve Disease

MalaCards organs/tissues related to Third Cranial Nerve Disease:

42
Eye, Brain

Publications for Third Cranial Nerve Disease

Articles related to Third Cranial Nerve Disease:

(show all 16)
# Title Authors Year
1
Ethmoidal mucocele presenting as oculomotor nerve paralysis. ( 23799169 )
2013
2
Neurobrucellosis developing unilateral oculomotor nerve paralysis. ( 22244219 )
2012
3
Unilateral isolated partial oculomotor nerve paralysis after percutaneous intervention. ( 19054794 )
2009
4
Asymmetric FDG uptake in the extraocular muscles resulting from oculomotor nerve paralysis. ( 19387218 )
2009
5
Transient isolated oculomotor nerve paralysis in neonatal group B streptococcal meningitis. ( 18377371 )
2008
6
Möbius syndrome with oculomotor nerve paralysis without abducens paralysis. ( 9858013 )
1998
7
Isolated oculomotor nerve paralysis in Lyme disease: MRI. ( 9045977 )
1997
8
Oculomotor nerve paralysis induced by alpha II-interferon. ( 2114727 )
1990
9
Reversible nuclear oculomotor nerve paralysis. Caused by a primary mesencephalic hemorrhage. ( 2358005 )
1990
10
Locked-in syndrome with bilateral ptosis: combination of bilateral horizontal pontine gaze paralysis and nuclear oculomotor nerve paralysis. ( 4078603 )
1985
11
Miosis from echothiophate in patients with total oculomotor nerve paralysis from intracranial abnormalities. ( 7211995 )
1981
12
Oculomotor nerve paralysis of unknown aetiology (a clinical study). ( 15744964 )
1971
13
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. ( 5803809 )
1969
14
Oculomotor nerve paralysis. ( 6024149 )
1967
15
NEURO-OPHTHALMOLOGIC EVALUATION OF OCULOMOTOR NERVE PARALYSIS. ( 14162937 )
1964
16
Aneurysm of the intracranial carotid artery; syndrome of frontal headache with oculomotor nerve paralysis. ( 15401446 )
1950

Variations for Third Cranial Nerve Disease

Expression for Third Cranial Nerve Disease

Search GEO for disease gene expression data for Third Cranial Nerve Disease.

Pathways for Third Cranial Nerve Disease

GO Terms for Third Cranial Nerve Disease

Biological processes related to Third Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 8.62 AVP MBP

Sources for Third Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....