MCID: THR010
MIFTS: 26

Third Cranial Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Third Cranial Nerve Disease

MalaCards integrated aliases for Third Cranial Nerve Disease:

Name: Third Cranial Nerve Disease 12 15
Disorder of Oculomotor Nerve 12
Third Cranial Nerve Disorder 74
Oculomotor Nerve Paralysis 74
Oculomotor Nerve Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:562
NCIt 51 C27598
SNOMED-CT 69 60750009

Summaries for Third Cranial Nerve Disease

MalaCards based summary : Third Cranial Nerve Disease, also known as disorder of oculomotor nerve, is related to central pontine myelinolysis and anal spasm, and has symptoms including ophthalmoparesis, ophthalmoplegia and setting-sun eye phenomenon. An important gene associated with Third Cranial Nerve Disease is ARHGEF1 (Rho Guanine Nucleotide Exchange Factor 1). The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Third Cranial Nerve Disease

Diseases related to Third Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 central pontine myelinolysis 10.2 AVP MBP
2 anal spasm 10.2 CAMP KANTR
3 facial hemiatrophy 10.2 ARHGEF1 KANTR
4 secondary hypertrophic osteoarthropathy 10.2 AVP SMUG1
5 brain germinoma 10.2 AFP AVP
6 paraphimosis 10.2 CAMP KANTR
7 tuberculous epididymitis 10.2 AFP AVP
8 cranial nerve disease 10.2 KANTR MBP
9 anismus 10.2 CAMP KANTR
10 central nervous system germ cell tumor 10.2 AFP AVP
11 granulomatous angiitis 10.2 AVP MBP
12 malignant teratoma 10.1 AFP AVP
13 dental abscess 10.1 AVP KANTR
14 alexia 10.1 KANTR MBP
15 sphenoid sinusitis 10.1 AVP KANTR
16 liver lymphoma 10.1 AFP SMUG1
17 extragonadal nonseminomatous germ cell tumor 10.1 AFP SMUG1
18 sternum cancer 10.1 AFP SMUG1
19 corpus luteum cyst 10.1 AFP SMUG1
20 extragonadal germ cell cancer 10.1 AFP SMUG1
21 dystonia 1, torsion, autosomal dominant 10.1 CAMP KANTR
22 tabes dorsalis 10.1 KANTR MBP
23 anterior spinal artery syndrome 10.1 KANTR MBP
24 mediastinal cancer 10.1 AFP SMUG1
25 internuclear ophthalmoplegia 10.1 KANTR MBP
26 mature teratoma 10.1 AFP SMUG1
27 laryngeal tuberculosis 10.1 KANTR SMUG1
28 carotid artery dissection 10.0 AVP KANTR
29 plexopathy 10.0 AVP CAMP SMUG1
30 tertiary neurosyphilis 10.0 KANTR MBP
31 anus disease 10.0 KANTR SMUG1
32 cloacal exstrophy 10.0 AFP KANTR
33 premenstrual tension 10.0 AVP CAMP KANTR
34 esophageal disease 10.0 KANTR SMUG1
35 uterine anomalies 9.9 AFP SMUG1
36 hemidystonia 9.9 CAMP KANTR SMUG1
37 speech and communication disorders 9.9 KANTR SMUG1
38 tracheal cancer 9.9 AFP AVP SMUG1
39 gastrointestinal system cancer 9.9 AFP SMUG1
40 systemic lupus erythematosus 9.9
41 neuropathy 9.9
42 lupus erythematosus 9.9
43 nervous system disease 9.9 KANTR MBP SMUG1
44 testis seminoma 9.9 PNMA2 SMUG1
45 lateral medullary syndrome 9.9 KANTR PNMA2
46 branch retinal artery occlusion 9.8 KANTR PNMA2
47 endocrine gland cancer 9.8 AFP SMUG1
48 peripheral nervous system disease 9.7 KANTR MBP
49 agraphia 9.7 KANTR MBP PNMA2
50 peliosis hepatis 9.7 AFP PNMA2 SMUG1

Graphical network of the top 20 diseases related to Third Cranial Nerve Disease:



Diseases related to Third Cranial Nerve Disease

Symptoms & Phenotypes for Third Cranial Nerve Disease

UMLS symptoms related to Third Cranial Nerve Disease:


ophthalmoparesis, ophthalmoplegia, setting-sun eye phenomenon

Drugs & Therapeutics for Third Cranial Nerve Disease

Drugs for Third Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 23925 27284

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Ocular Electroacupuncture on Oculomotor Nerve Palsy Recruiting NCT03099447 Not Applicable
2 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
3 A Real-time Magnetic Device Prototype for Temporary Management of Blepharoptosis Recruiting NCT03812016 Not Applicable
4 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Third Cranial Nerve Disease

Genetic Tests for Third Cranial Nerve Disease

Anatomical Context for Third Cranial Nerve Disease

MalaCards organs/tissues related to Third Cranial Nerve Disease:

42
Eye

Publications for Third Cranial Nerve Disease

Articles related to Third Cranial Nerve Disease:

(show all 16)
# Title Authors Year
1
Ethmoidal mucocele presenting as oculomotor nerve paralysis. ( 23799169 )
2013
2
Neurobrucellosis developing unilateral oculomotor nerve paralysis. ( 22244219 )
2012
3
Asymmetric FDG uptake in the extraocular muscles resulting from oculomotor nerve paralysis. ( 19387218 )
2009
4
Unilateral isolated partial oculomotor nerve paralysis after percutaneous intervention. ( 19054794 )
2009
5
Transient isolated oculomotor nerve paralysis in neonatal group B streptococcal meningitis. ( 18377371 )
2008
6
MAPbius syndrome with oculomotor nerve paralysis without abducens paralysis. ( 9858013 )
1998
7
Isolated oculomotor nerve paralysis in Lyme disease: MRI. ( 9045977 )
1997
8
Reversible nuclear oculomotor nerve paralysis. Caused by a primary mesencephalic hemorrhage. ( 2358005 )
1990
9
Oculomotor nerve paralysis induced by alpha II-interferon. ( 2114727 )
1990
10
Locked-in syndrome with bilateral ptosis: combination of bilateral horizontal pontine gaze paralysis and nuclear oculomotor nerve paralysis. ( 4078603 )
1985
11
Miosis from echothiophate in patients with total oculomotor nerve paralysis from intracranial abnormalities. ( 7211995 )
1981
12
Oculomotor nerve paralysis of unknown aetiology (a clinical study). ( 15744964 )
1971
13
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. ( 5803809 )
1969
14
Oculomotor nerve paralysis. ( 6024149 )
1967
15
NEURO-OPHTHALMOLOGIC EVALUATION OF OCULOMOTOR NERVE PARALYSIS. ( 14162937 )
1964
16
Aneurysm of the intracranial carotid artery; syndrome of frontal headache with oculomotor nerve paralysis. ( 15401446 )
1950

Variations for Third Cranial Nerve Disease

Expression for Third Cranial Nerve Disease

Search GEO for disease gene expression data for Third Cranial Nerve Disease.

Pathways for Third Cranial Nerve Disease

GO Terms for Third Cranial Nerve Disease

Sources for Third Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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