MCID: THR010
MIFTS: 26

Third Cranial Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Third Cranial Nerve Disease

MalaCards integrated aliases for Third Cranial Nerve Disease:

Name: Third Cranial Nerve Disease 12 15
Disorder of Oculomotor Nerve 12
Third Cranial Nerve Disorder 73
Oculomotor Nerve Paralysis 73
Oculomotor Nerve Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:562
NCIt 50 C27598
SNOMED-CT 68 60750009

Summaries for Third Cranial Nerve Disease

MalaCards based summary : Third Cranial Nerve Disease, also known as disorder of oculomotor nerve, is related to alternating esotropia and central pontine myelinolysis, and has symptoms including ophthalmoparesis, ophthalmoplegia and setting-sun eye phenomenon. An important gene associated with Third Cranial Nerve Disease is CHN1 (Chimerin 1). Affiliated tissues include eye, brain and liver.

Related Diseases for Third Cranial Nerve Disease

Diseases related to Third Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 alternating esotropia 10.1 CHN1 KANTR
2 central pontine myelinolysis 10.1 AVP MBP
3 brain germinoma 10.1 AFP AVP
4 accommodative esotropia 10.1 CHN1 KANTR
5 tuberculous epididymitis 10.1 AFP AVP
6 central nervous system germ cell tumor 10.1 AFP AVP
7 anal spasm 10.1 CAMP KANTR
8 facial hemiatrophy 10.1 ARHGEF1 KANTR
9 malignant teratoma 10.1 AFP AVP
10 paraphimosis 10.1 CAMP KANTR
11 anismus 10.1 CAMP KANTR
12 abducens nerve disease 10.1 CHN1 KANTR
13 hypotropia 10.1 CHN1 KANTR
14 dental abscess 10.1 AVP KANTR
15 secondary hypertrophic osteoarthropathy 10.1 AVP SMUG1
16 granulomatous angiitis 10.1 AVP MBP
17 hypertropia 10.1 CHN1 KANTR
18 alexia 10.1 KANTR MBP
19 sphenoid sinusitis 10.1 AVP KANTR
20 liver lymphoma 10.1 AFP SMUG1
21 extragonadal nonseminomatous germ cell tumor 10.1 AFP SMUG1
22 ametropic amblyopia 10.1 CHN1 MTRNR2L4
23 sternum cancer 10.1 AFP SMUG1
24 corpus luteum cyst 10.1 AFP SMUG1
25 extragonadal germ cell cancer 10.1 AFP SMUG1
26 tabes dorsalis 10.1 KANTR MBP
27 dystonia 1, torsion, autosomal dominant 10.1 CAMP KANTR
28 anterior spinal artery syndrome 10.1 KANTR MBP
29 mediastinal cancer 10.1 AFP SMUG1
30 mature teratoma 10.1 AFP SMUG1
31 internuclear ophthalmoplegia 10.1 KANTR MBP
32 paralytic squint 10.0 CHN1 KANTR
33 laryngeal tuberculosis 10.0 KANTR SMUG1
34 tertiary neurosyphilis 10.0 KANTR MBP
35 cloacal exstrophy 10.0 AFP KANTR
36 ocular motility disease 10.0 CHN1 KANTR
37 cranial nerve disease 10.0 CHN1 KANTR MBP
38 plexopathy 10.0 AVP CAMP SMUG1
39 carotid artery dissection 10.0 AVP KANTR
40 premenstrual tension 10.0 AVP CAMP KANTR
41 peripheral nervous system disease 10.0 CHN1 KANTR MBP
42 anus disease 10.0 KANTR SMUG1
43 lymphedema, hereditary, ii 10.0 CAMP KANTR
44 tracheal cancer 10.0 AFP AVP SMUG1
45 hemidystonia 9.9 CAMP KANTR SMUG1
46 nervous system disease 9.9 KANTR MBP SMUG1
47 lateral medullary syndrome 9.9 KANTR PNMA2
48 branch retinal artery occlusion 9.9 KANTR PNMA2
49 testis seminoma 9.9 PNMA2 SMUG1
50 systemic lupus erythematosus 9.9

Graphical network of the top 20 diseases related to Third Cranial Nerve Disease:



Diseases related to Third Cranial Nerve Disease

Symptoms & Phenotypes for Third Cranial Nerve Disease

UMLS symptoms related to Third Cranial Nerve Disease:


ophthalmoparesis, ophthalmoplegia, setting-sun eye phenomenon

Drugs & Therapeutics for Third Cranial Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Ocular Electroacupuncture on Oculomotor Nerve Palsy Recruiting NCT03099447 Not Applicable
2 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
3 A Real-time Magnetic Device Prototype for Temporary Management of Blepharoptosis Recruiting NCT03812016 Not Applicable
4 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Third Cranial Nerve Disease

Genetic Tests for Third Cranial Nerve Disease

Anatomical Context for Third Cranial Nerve Disease

MalaCards organs/tissues related to Third Cranial Nerve Disease:

41
Eye, Brain, Liver, Testis

Publications for Third Cranial Nerve Disease

Articles related to Third Cranial Nerve Disease:

(show all 16)
# Title Authors Year
1
Ethmoidal mucocele presenting as oculomotor nerve paralysis. ( 23799169 )
2013
2
Neurobrucellosis developing unilateral oculomotor nerve paralysis. ( 22244219 )
2012
3
Asymmetric FDG uptake in the extraocular muscles resulting from oculomotor nerve paralysis. ( 19387218 )
2009
4
Unilateral isolated partial oculomotor nerve paralysis after percutaneous intervention. ( 19054794 )
2009
5
Transient isolated oculomotor nerve paralysis in neonatal group B streptococcal meningitis. ( 18377371 )
2008
6
MAPbius syndrome with oculomotor nerve paralysis without abducens paralysis. ( 9858013 )
1998
7
Isolated oculomotor nerve paralysis in Lyme disease: MRI. ( 9045977 )
1997
8
Reversible nuclear oculomotor nerve paralysis. Caused by a primary mesencephalic hemorrhage. ( 2358005 )
1990
9
Oculomotor nerve paralysis induced by alpha II-interferon. ( 2114727 )
1990
10
Locked-in syndrome with bilateral ptosis: combination of bilateral horizontal pontine gaze paralysis and nuclear oculomotor nerve paralysis. ( 4078603 )
1985
11
Miosis from echothiophate in patients with total oculomotor nerve paralysis from intracranial abnormalities. ( 7211995 )
1981
12
Oculomotor nerve paralysis of unknown aetiology (a clinical study). ( 15744964 )
1971
13
Osteochondroma of the base of the skull causing an isolated oculomotor nerve paralysis. Case report emphasizing microsurgical techniques. ( 5803809 )
1969
14
Oculomotor nerve paralysis. ( 6024149 )
1967
15
NEURO-OPHTHALMOLOGIC EVALUATION OF OCULOMOTOR NERVE PARALYSIS. ( 14162937 )
1964
16
Aneurysm of the intracranial carotid artery; syndrome of frontal headache with oculomotor nerve paralysis. ( 15401446 )
1950

Variations for Third Cranial Nerve Disease

Expression for Third Cranial Nerve Disease

Search GEO for disease gene expression data for Third Cranial Nerve Disease.

Pathways for Third Cranial Nerve Disease

GO Terms for Third Cranial Nerve Disease

Sources for Third Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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