MCID: THR099
MIFTS: 42

Third-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Third-Degree Atrioventricular Block

MalaCards integrated aliases for Third-Degree Atrioventricular Block:

Name: Third-Degree Atrioventricular Block 12 15
Third Degree Atrioventricular Block 6
Complete Atrioventricular Block 70
Complete Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050823
ICD10 32 I44.2
UMLS 70 C0151517

Summaries for Third-Degree Atrioventricular Block

Disease Ontology : 12 An atrioventricular block that is characterized by bradycardia, hypotension, hemodynamic instability and complete dissociation between P waves and QRS complexes on electrocardiogram caused when conduction fails to propagate from atria to ventricles.

MalaCards based summary : Third-Degree Atrioventricular Block, also known as third degree atrioventricular block, is related to first-degree atrioventricular block and syncope. An important gene associated with Third-Degree Atrioventricular Block is TTN (Titin), and among its related pathways/superpathways are cGMP-PKG signaling pathway and Cardiac conduction. Affiliated tissues include heart, atrioventricular node and eye, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 73 Third-degree atrioventricular block (AV block) is a medical condition in which the nerve impulse... more...

Related Diseases for Third-Degree Atrioventricular Block

Diseases related to Third-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 first-degree atrioventricular block 31.3 TRIM21 SCN5A NPPB KCNJ2 KCNH2 ACE
2 syncope 31.0 TTN SCN5A KCNH2
3 progressive familial heart block, type ia 30.9 SCN5A GJA5
4 inferior myocardial infarction 30.8 NPPB ACE
5 myocarditis 30.8 TTN NPPB ACE
6 congestive heart failure 30.8 TTN SCN5A NPPB ACE
7 heart septal defect 30.7 TBX18 RNU4ATAC GJA5
8 restrictive cardiomyopathy 30.5 TTN-AS1 TTN NPPB ACE
9 left bundle branch hemiblock 30.4 SCN5A NPPB ACE
10 anterolateral myocardial infarction 30.4 NPPB ACE
11 cardiac tamponade 30.4 NPPB ACE
12 rheumatic heart disease 30.3 NPPB GJA5 ACE
13 mitral valve insufficiency 30.3 TTN NPPB ACE
14 second-degree atrioventricular block 30.3 TRIM21 SSB SCN5A HCN4 CACNA1D
15 aortic valve disease 2 30.2 TTN NPPB ACE
16 atrioventricular block 30.1 TTN-AS1 TTN TRIM21 SSB SCN5A NPPB
17 neuromuscular disease 29.8 TTN-AS1 TTN SCN5A KCNH2
18 hypokalemia 29.8 KCNH2 CACNA1D ACE
19 atrial standstill 1 29.6 TTN-AS1 TTN SCN5A SCN1B NPPB GJA5
20 cardiac arrest 29.6 TTN SCN5A NPPB KCNH2 HCN4 ACE
21 right bundle branch block 29.5 SCN5A SCN1B NPPB KCNH2 HCN4 ACE
22 atrial heart septal defect 29.4 TTN TBX18 SCN5A RNU4ATAC NPPB HCN4
23 arrhythmogenic right ventricular cardiomyopathy 29.3 TTN SCN5A NPPB KCNH2 HCN4 CACNA1D
24 heart disease 28.9 TTN SCN5A NPPB KCNJ2 KCNH2 HCN4
25 atrial fibrillation 28.6 TTN-AS1 TTN SCN5A SCN1B NPPB KCNJ2
26 hypertrophic cardiomyopathy 28.5 TTN-AS1 TTN SCN5A NPPB KCNJ2 KCNH2
27 long qt syndrome 28.0 TTN-AS1 TTN SCN5A SCN1B KCNJ2 KCNJ12
28 dilated cardiomyopathy 27.8 TTN-AS1 TTN SCN5A NPPB KCNJ2 KCNJ12
29 left ventricular noncompaction 2 10.4 TTN-AS1 TTN
30 autosomal dominant distal myopathy 10.4 TTN-AS1 TTN
31 infective endocarditis 10.3
32 endocarditis 10.3
33 multiminicore disease 10.3 TTN-AS1 TTN
34 diffuse infiltrative lymphocytosis syndrome 10.3 TRIM21 SSB
35 atrial standstill 10.3 SCN5A GJA5
36 cardiac tuberculosis 10.3 NPPB ACE
37 toxic myocarditis 10.3 NPPB ACE
38 granulomatous myositis 10.3 TRIM21 ACE
39 parotid disease 10.3 TRIM21 SSB
40 familial sick sinus syndrome 10.3 SCN5A HCN4
41 perinephritis 10.3 TTN ACE
42 idiopathic edema 10.3 NPPB ACE
43 hereditary lymphedema ic 10.3 SCN5A GJA5
44 neuropathy, hereditary sensory and autonomic, type iii 10.3
45 progressive familial heart block, type ib 10.3
46 myocardial infarction 10.3
47 hemopericardium 10.3
48 pericardial effusion 10.3
49 ventricular septal defect 10.3
50 subvalvular aortic stenosis 10.3

Comorbidity relations with Third-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 28)


Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Atrioventricular Block
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Disease Deficiency Anemia
Dressler's Syndrome Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Kidney Disease Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Monocular Esotropia
Peripheral Vascular Disease Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sinoatrial Node Disease
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Third-Degree Atrioventricular Block:



Diseases related to Third-Degree Atrioventricular Block

Symptoms & Phenotypes for Third-Degree Atrioventricular Block

MGI Mouse Phenotypes related to Third-Degree Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ACE CACNA1D GJA5 HCN4 KCNH2 KCNJ12
2 mortality/aging MP:0010768 9.73 ACE CACNA1D GJA5 HCN4 KCNH2 KCNJ2
3 muscle MP:0005369 9.17 GJA5 HCN4 KCNH2 KCNJ2 SCN5A TBX18

Drugs & Therapeutics for Third-Degree Atrioventricular Block

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Impact of Left Ventricular Pacing on Left Ventricular Systolic Function in High-risk Bradycardia Patients Unknown status NCT01302717
2 Junctional AV Ablation in CRT-D Patients With Atrial Fibrillation (JAVA-CRT Trial) Completed NCT02946853
3 Evaluation of Atrial Fibrillation Occurrence in Sick Sinus and Complete Atrioventricular Block Patients After Pacemaker Implantation (AF-pacemaker Study) Recruiting NCT03303872

Search NIH Clinical Center for Third-Degree Atrioventricular Block

Genetic Tests for Third-Degree Atrioventricular Block

Anatomical Context for Third-Degree Atrioventricular Block

MalaCards organs/tissues related to Third-Degree Atrioventricular Block:

40
Heart, Atrioventricular Node, Eye, Retina, Lung, Salivary Gland, Adrenal Gland

Publications for Third-Degree Atrioventricular Block

Articles related to Third-Degree Atrioventricular Block:

(show top 50) (show all 427)
# Title Authors PMID Year
1
Novel missense variant in TTN cosegregating with familial atrioventricular block. 6
31470098 2020
2
Unusual Presentation of Aortic Valve Infective Endocarditis in a Dog: Aorto-Cavitary Fistula, Tricuspid Valve Endocarditis, and Third-Degree Atrioventricular Block. 61
33806631 2021
3
A case report of inappropriate inhibition of ventricular pacing due to a unique pacemaker electrogram storage feature. 61
33768197 2021
4
A Validated Smartphone-based Electrocardiogram Reveals Severe Bradyarrhythmias during Immobilizing Restraint in Mice of Both Sexes and Four Strains. 61
33637137 2021
5
Association between routine biomarkers and atrial fibrillation in patients undergoing implantation of a dual-chamber pacemaker. 61
33664906 2021
6
Use and Outcomes of Dual Chamber or Cardiac Resynchronization Therapy Defibrillators Among Older Patients Requiring Ventricular Pacing in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry. 61
33496796 2021
7
Routine Measurement of Thyroid Stimulating Hormone in Patients Presenting With Third-Degree Atrioventricular Block: Do We Really Need It? 61
33614317 2021
8
A pacemaker-assisted microvascular decompression for a patient with left primary facial spasm and arrhythmia: a case report. 61
33407329 2021
9
Transcatheter Aortic Valve Replacement in Aortic Regurgitation. 61
32407852 2020
10
Unusual Midventricular LV Obstruction With Flow Aimed to the Apex Due to Apical RV Pacing: Elimination by Sequential Septo-Apical RV Pacing. 61
32417226 2020
11
Simplifying transfemoral ACURATE neo implantation using the TrueFlow nonocclusive balloon catheter. 61
31971346 2020
12
The importance of heart rate in isoprenaline-induced takotsubo-like cardiac dysfunction in rats. 61
32686334 2020
13
Asymmetric Occluder Occlusion of Outlet Ventricular Septal Defect via a Subaxillary Approach. 61
33080233 2020
14
Case report: third-degree atrioventricular block secondary to septic coronary artery embolism following infective endocarditis. 61
33204940 2020
15
A case report of delayed diagnosis of danon disease: Caused by a newly recognized mutation in the lysosome-associated membrane protein-2 gene. 61
33019488 2020
16
Twenty-four-hour ambulatory (Holter) electrocardiographic findings in 13 cats with non-hypertrophic cardiomyopathy. 61
33012440 2020
17
Clinical Features, Autoantibodies, and Outcome of Neonatal Lupus Erythematosus. 61
33103534 2020
18
Long Term Outcomes Of Tricuspid Valve Replacement. 61
33280289 2020
19
Familial dilated cardiomyopathy caused by a novel variant in the Lamin A/C gene: a case report. 61
32962641 2020
20
The association of cannabis use and cardiac dysrhythmias: a systematic review. 61
32267189 2020
21
Symmetrical and Peripheral Gangrene Complicating a Third-Degree Atrioventricular Block: A New Presentation of a Known Disease. 61
33083179 2020
22
Multiple Valve Implantation Through a Minimally Invasive Approach: Comparison of Standard Median Sternotomy and Right Anterior Thoracotomy. 61
32249168 2020
23
Complete recovery of fulminant cytotoxic CD8 T-cell-mediated myocarditis after ECMELLA unloading and immunosuppression. 61
32485066 2020
24
Treatment of atrial fibrillation with third-degree atrioventricular block by pacing His bundle and left bundle branch: Case report. 61
32871980 2020
25
Third-Degree Atrioventricular Block as the Initial Presentation of Lyme Disease. 61
32782894 2020
26
Catheter ablation of the cavotricuspid isthmus in patients with atrial flutter: predictors of long-term outcomes. 61
32500993 2020
27
Safety of regadenoson positron emission tomography stress testing in orthotopic heart transplant patients. 61
30483958 2020
28
Permanent left bundle branch area pacing in a child with a third-degree atrioventricular block: A case report. 61
32337777 2020
29
A Different Breed of Wolf: First Known Case of Wolf-Hirschorn Syndrome with Third-degree Atrioventricular Block Requiring Pacemaker Implantation. 61
32596030 2020
30
Simplified, minimally invasive, beating-heart technique for redo isolated tricuspid valve surgery. 61
32552843 2020
31
Successful implantation of leadless pacemakers in children: a case series. 61
32617462 2020
32
A comparative study of minimal lower-sternal incision device closure, minimal right thoracic incision device closure, and midsternal open repair of isolated perimembranous VSD, a retrospective cohort study. 61
31785954 2020
33
A case report of one vasovagal syncope patient with third-degree atrioventricular block caused by SCN5A gene mutation and literature review. 61
32398054 2020
34
[Third degree atrio-ventricular blockade during a myocarditis occurring under anti-PD1 : Case report and literature review]. 61
31983550 2020
35
Complete Heart Block in Systemic Sclerosis with Characterization on Cardiac MRI. 61
32670478 2020
36
Arrhythmias in Patients on Maintenance Dialysis: A Cross-sectional Study. 61
31542235 2020
37
[Clinical observation on six children of left bundle branch area pacing]. 61
32102146 2020
38
Surgical treatment results of secondary tunnel-like subaortic stenosis after congenital heart disease operations: A 7-year, single-center experience in 25 patients. 61
31765039 2020
39
[The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2018]. 61
32051640 2020
40
First-in-Human Experience With Patient-Specific Computer Simulation of TAVR in Bicuspid Aortic Valve Morphology. 61
31629752 2020
41
Ozanimod for Treatment of Relapsing-Remitting Multiple Sclerosis in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 61
33658933 2020
42
Left Bundle Pacing for Left Bundle Branch Block and Intermittent Third-Degree Atrioventricular Block in a MYH7 Mutation-Related Hypertrophic Cardiomyopathy With Restrictive Phenotype in a Child. 61
32612965 2020
43
Utility of 30-Day Continuous Ambulatory Monitoring to Identify Patients With Delayed Occurrence of Atrioventricular Block After Transcatheter Aortic Valve Replacement. 61
31833417 2019
44
Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery. 61
31623840 2019
45
Early Change in Global Longitudinal Strain is an Independent Predictor of Left Ventricular Adverse Remodelling in Patients With Right Ventricular Apical Pacing. 61
30503810 2019
46
The predictive value of PRECISE-DAPT score for arrhythmic complications in patients with ST-elevation myocardial infarction. 61
31567370 2019
47
The yield of long-term electrocardiographic recordings in refractory focal epilepsy. 61
31637707 2019
48
Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial. 61
31492651 2019
49
Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic. 61
31729968 2019
50
Cardiac and Neuromuscular Features of Patients With LMNA-Related Cardiomyopathy. 61
31476771 2019

Variations for Third-Degree Atrioventricular Block

ClinVar genetic disease variations for Third-Degree Atrioventricular Block:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TTN-AS1 , TTN NM_001267550.2(TTN):c.49287C>A (p.Asn16429Lys) SNV Likely pathogenic 634902 rs763809932 GRCh37: 2:179478837-179478837
GRCh38: 2:178614110-178614110

Expression for Third-Degree Atrioventricular Block

Search GEO for disease gene expression data for Third-Degree Atrioventricular Block.

Pathways for Third-Degree Atrioventricular Block

Pathways related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 SCN5A SCN1B NPPB CACNA1D
2
Show member pathways
12.23 TTN SCN5A SCN1B KCNJ2 KCNJ12 KCNH2
3
Show member pathways
12.16 NPPB KCNJ2 KCNJ12 CACNA1D
4 11.98 KCNJ2 KCNJ12 KCNH2 CACNA1D
5
Show member pathways
11.63 KCNJ2 KCNJ12 KCNH2 HCN4
6
Show member pathways
11.42 SCN5A SCN1B CACNA1D
7 11.27 KCNJ2 CACNA1D ACE
8 10.92 SCN5A SCN1B KCNJ2 KCNH2 HCN4 GJA5
9 10.74 KCNJ2 HCN4

GO Terms for Third-Degree Atrioventricular Block

Cellular components related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.5 TTN SCN5A CACNA1D
2 voltage-gated sodium channel complex GO:0001518 9.26 SCN5A SCN1B
3 intrinsic component of membrane GO:0031224 9.16 KCNJ2 KCNJ12
4 T-tubule GO:0030315 9.13 SCN5A SCN1B KCNJ2
5 intercalated disc GO:0014704 8.92 SCN5A SCN1B KCNJ2 GJA5

Biological processes related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.04 SCN5A SCN1B KCNJ2 KCNJ12 KCNH2 HCN4
2 transmembrane transport GO:0055085 10.01 SCN5A KCNH2 HCN4 GJA5 CACNA1D
3 ion transmembrane transport GO:0034220 9.9 SCN5A SCN1B KCNH2 CACNA1D
4 potassium ion transport GO:0006813 9.88 KCNJ2 KCNJ12 KCNH2 HCN4 GJA5
5 potassium ion transmembrane transport GO:0071805 9.83 KCNJ2 KCNH2 HCN4
6 sodium ion transport GO:0006814 9.82 SCN5A SCN1B HCN4
7 regulation of ion transmembrane transport GO:0034765 9.8 SCN5A SCN1B KCNJ2 KCNJ12 KCNH2 HCN4
8 muscle contraction GO:0006936 9.79 TTN KCNJ12 HCN4
9 sodium ion transmembrane transport GO:0035725 9.78 SCN5A SCN1B HCN4
10 cardiac muscle contraction GO:0060048 9.73 TTN SCN5A SCN1B KCNH2
11 potassium ion import across plasma membrane GO:1990573 9.71 KCNJ2 KCNJ12 KCNH2 HCN4
12 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.69 SCN5A SCN1B KCNH2
13 regulation of blood vessel diameter GO:0097746 9.66 NPPB ACE
14 regulation of cardiac muscle contraction GO:0055117 9.65 HCN4 GJA5
15 membrane depolarization GO:0051899 9.65 SCN5A SCN1B
16 regulation of potassium ion transmembrane transport GO:1901379 9.64 KCNH2 CACNA1D
17 ventricular cardiac muscle cell action potential GO:0086005 9.63 SCN5A KCNH2
18 membrane depolarization during action potential GO:0086010 9.63 SCN5A KCNH2
19 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.63 SCN5A SCN1B GJA5
20 cardiac conduction GO:0061337 9.63 SCN5A SCN1B KCNJ2 KCNJ12 KCNH2 CACNA1D
21 positive regulation of sodium ion transport GO:0010765 9.62 SCN5A SCN1B
22 cardiac muscle cell action potential involved in contraction GO:0086002 9.62 SCN5A SCN1B KCNJ2 CACNA1D
23 positive regulation of potassium ion transmembrane transport GO:1901381 9.59 KCNJ2 KCNH2
24 regulation of cardiac muscle cell contraction GO:0086004 9.58 SCN5A KCNJ2
25 regulation of membrane repolarization GO:0060306 9.58 KCNJ2 KCNH2
26 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.57 KCNJ2 KCNH2
27 membrane repolarization during action potential GO:0086011 9.56 KCNJ2 KCNH2
28 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.55 SCN5A CACNA1D
29 SA node cell action potential GO:0086015 9.54 SCN5A HCN4
30 membrane depolarization during SA node cell action potential GO:0086046 9.54 SCN5A HCN4 CACNA1D
31 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.52 SCN5A SCN1B
32 regulation of heart rate by cardiac conduction GO:0086091 9.43 SCN5A SCN1B KCNJ2 KCNH2 HCN4 CACNA1D
33 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.02 SCN5A SCN1B KCNJ2 HCN4 CACNA1D

Molecular functions related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.71 SCN5A KCNH2 HCN4 CACNA1D
2 sodium channel activity GO:0005272 9.5 SCN5A SCN1B HCN4
3 ankyrin binding GO:0030506 9.46 SCN5A CACNA1D
4 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.43 KCNJ2 KCNH2
5 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.37 SCN5A SCN1B
6 voltage-gated sodium channel activity GO:0005248 9.33 SCN5A SCN1B HCN4
7 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.26 SCN5A SCN1B
8 voltage-gated ion channel activity GO:0005244 9.17 SCN5A SCN1B KCNJ2 KCNJ12 KCNH2 HCN4
9 inward rectifier potassium channel activity GO:0005242 9.13 KCNJ2 KCNJ12 KCNH2

Sources for Third-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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