MCID: THR099
MIFTS: 35

Third-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Third-Degree Atrioventricular Block

MalaCards integrated aliases for Third-Degree Atrioventricular Block:

Name: Third-Degree Atrioventricular Block 12 15
Third Degree Atrioventricular Block 29
Complete Atrioventricular Block 73
Complete Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050823
UMLS 73 C0151517

Summaries for Third-Degree Atrioventricular Block

MalaCards based summary : Third-Degree Atrioventricular Block, also known as third degree atrioventricular block, is related to atrioventricular block and atrial fibrillation. An important gene associated with Third-Degree Atrioventricular Block is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways is Antiarrhythmic Pathway, Pharmacodynamics. The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and prostate.

Wikipedia : 76 Third-degree atrioventricular block (AV block), also known as complete heart block, is a medical... more...

Related Diseases for Third-Degree Atrioventricular Block

Diseases related to Third-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 30.4 HCN4 KCNE2 NPPB
2 atrial fibrillation 29.4 HCN4 KCNE2 NPPB
3 neuropathy, hereditary sensory and autonomic, type iii 10.1
4 second-degree atrioventricular block 10.1
5 myocarditis 10.1
6 dysautonomia 10.1
7 syncope 10.1
8 schizoaffective disorder 10.0
9 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1 10.0
10 myositis 10.0
11 pheochromocytoma 10.0
12 myocardial infarction 10.0
13 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2 10.0
14 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 10.0
15 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4 10.0
16 b-cell lymphomas 10.0
17 lymphoma 10.0
18 endocarditis 10.0
19 cardiac tamponade 10.0
20 chronic progressive external ophthalmoplegia 10.0
21 melanoma 10.0
22 acute myocarditis 10.0
23 pulmonary embolism 10.0
24 bronchogenic cyst 10.0
25 double outlet right ventricle 9.8
26 heart conduction disease 9.8 HCN4 NPPB TRIM21
27 heart block, congenital 9.7 TRIM21 TROVE2
28 salivary gland disease 9.7 TRIM21 TROVE2
29 cogan syndrome 9.6 TRIM21 TROVE2
30 cutaneous lupus erythematosus 9.6 TRIM21 TROVE2
31 atrial standstill 1 9.6 NPPB PRKAG2
32 primary sjögren syndrome 9.5 TRIM21 TROVE2
33 sjogren syndrome 9.4 TRIM21 TROVE2

Comorbidity relations with Third-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 30)


Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Atrioventricular Block
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Dressler's Syndrome
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Kidney Disease Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Monocular Esotropia
Peripheral Vascular Disease Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sinoatrial Node Disease
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Third-Degree Atrioventricular Block:



Diseases related to Third-Degree Atrioventricular Block

Symptoms & Phenotypes for Third-Degree Atrioventricular Block

Drugs & Therapeutics for Third-Degree Atrioventricular Block

Drugs for Third-Degree Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 1 979-32-8
3
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
4
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
5
Moxifloxacin Approved, Investigational Phase 4,Phase 1 354812-41-2, 151096-09-2 152946
6
Norgestimate Approved, Investigational Phase 4,Phase 1 35189-28-7 6540478
7
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
8
Polyestradiol phosphate Approved Phase 4,Phase 1 28014-46-2
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Contraceptive Agents Phase 4,Phase 1
12 Contraceptives, Oral Phase 4,Phase 1
13 Contraceptives, Oral, Combined Phase 4,Phase 1
14 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
15 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1
16 Estradiol 17 beta-cypionate Phase 4,Phase 1
17 Estradiol 3-benzoate Phase 4,Phase 1
18 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 1
19 Renal Agents Phase 4,Phase 3
20 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 1
21
Adenosine Approved, Investigational Phase 3,Phase 2 58-61-7 60961
22
Aripiprazole Approved, Investigational Phase 3 129722-12-9 60795
23
rituximab Approved Phase 3 174722-31-7 10201696
24
Regadenoson Approved, Investigational Phase 3 313348-27-5 219024
25
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 439542 10909430
26
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
27
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
28
Digoxin Approved Phase 3 20830-75-5 30322 2724385
29
Binodenoson Investigational Phase 3 144348-08-3
30 Anti-Arrhythmia Agents Phase 3,Phase 1,Phase 2
31 Neurotransmitter Agents Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 3
33 Protective Agents Phase 3
34 Antibodies Phase 2, Phase 3
35 Autoantibodies Phase 2, Phase 3
36 gamma-Globulins Phase 2, Phase 3
37 Immunoglobulins Phase 2, Phase 3
38 Immunoglobulins, Intravenous Phase 2, Phase 3
39 Rho(D) Immune Globulin Phase 2, Phase 3
40 Analgesics Phase 3
41 Vasodilator Agents Phase 3,Phase 1,Phase 2
42 Antipsychotic Agents Phase 3
43 Central Nervous System Depressants Phase 3
44 Psychotropic Drugs Phase 3
45 Tranquilizing Agents Phase 3
46 Alkylating Agents Phase 3
47 Antineoplastic Agents, Alkylating Phase 3
48 Antirheumatic Agents Phase 3,Phase 2
49 Bendamustine Hydrochloride Phase 3
50 Antibiotics, Antitubercular Phase 3

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
2 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
3 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
4 Catheter Evaluation for Endocardial Ablation in Patients With Typical Atrial Flutter Completed NCT00318565 Phase 4
5 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
6 Syncope: Pacing or Recording in the Later Years Active, not recruiting NCT01423994 Phase 4
7 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
8 First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) Unknown status NCT00392054 Phase 3 Conventional Antiarrhythmic Drug Therapy
9 Preventive IVIG Therapy for Congenital Heart Block Completed NCT00460928 Phase 2, Phase 3 intravenous immune globulin (IVIG)
10 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3 binodenoson;adenosine
11 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3 binodenoson;adenosine
12 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
13 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
14 A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT) Completed NCT01618669 Phase 3 Regadenoson
15 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
16 Digoxin Short Term Treatment Assessment Randomized Trial in AHF Recruiting NCT02544815 Phase 3 Digoxin;Placebo
17 Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
18 The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid Cardiomyopathy Completed NCT00694161 Phase 2 Fx-1006A
19 Study to Investigate the Effects of Orteronel on the QT/QTc Interval in Patients With Metastatic Castration-Resistant Prostate Cancer Completed NCT01549951 Phase 2 Orteronel+Prednisone
20 Multiple Dose Study in Heart Failure of BAY 1067197 Completed NCT02040233 Phase 2 BAY1067197 (10 mg);BAY1067197;Placebo (10 mg);Placebo
21 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2 Hydroxychloroquine
22 Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps Recruiting NCT03102190 Phase 1, Phase 2 Verapamil Hydrochloride Intranasal
23 Study Assessing the Effects of Darunavir/Ritonavir or Lopinavir/Ritonavir on the Pharmacokinetics of Daclatasvir in Healthy Participants Completed NCT02159352 Phase 1 Daclatasvir;Darunavir;Ritonavir;Lopinavir/Ritonavir
24 Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder Completed NCT01423916 Phase 1 OPC-34712 (4mg);Moxifloxacin;OPC-34712 (12mg);Placebo
25 Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Completed NCT02050802 Phase 1 Moxifloxacin 400 mg;Macitentan 10 mg;Macitentan 30 mg
26 Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block Unknown status NCT01477658
27 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
28 Prognostic Accuracy of Coronary CT and Dobutamine Stress Echocardiography in Patient Undergoing Non-cardiac Surgery Unknown status NCT02250963
29 Exercise in Chronically Paced Children Completed NCT00374608
30 Electrophysiologic HV-interval as a Predicor for Permanent Pacemaker Implantation After TAVI Completed NCT01801098
31 PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular Pacing Completed NCT00461734 Not Applicable
32 Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome. Completed NCT01768949 Not Applicable
33 Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures Completed NCT00771927 Lacosamide
34 Plasma Glucagon-like Peptide-1 Levels and In-hospital Complications in ST-segment Elevation Myocardial Infarction Completed NCT03314844
35 Early Postoperative Blood Glucose Variability and Outcome After TAVI Completed NCT02726958
36 Association Between Plasma Melatonin and No-reflow Completed NCT03306303
37 Plasma Dipeptidyl-peptidase-4 Activities With No-reflow and Bleeding Completed NCT02849691
38 Indication of Permanent Cardiac Parcing After Tanscatheter Aortic Valve Implantation Completed NCT02337140 Not Applicable
39 HAART 200 Aortic Valve Annuloplasty Trial Completed NCT02071849 Not Applicable
40 HAART Model 300 Annuloplasty Ring Completed NCT01400841 Not Applicable
41 The HAART 300 Annuloplasty Ring Trial Extended Safety and Performance Completed NCT01732835 Not Applicable
42 Evaluation of Atrial Fibrillation Occurrence in Sick Sinus and Complete Atrioventricular Block Patients After Pacemaker Implantation (AF-pacemaker Study) Recruiting NCT03303872
43 Microfidelity (MIFI) Ablation Technology Versus Standard Ablation Catheter for Atrioventricular Nodal Ablation Recruiting NCT03114124 Not Applicable
44 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717 Not Applicable
45 Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms Recruiting NCT02881671
46 Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study Recruiting NCT02153307 Not Applicable
47 Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device Recruiting NCT02559011
48 Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement Recruiting NCT03163836
49 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Recruiting NCT03118440 Not Applicable
50 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Recruiting NCT03118427 Not Applicable

Search NIH Clinical Center for Third-Degree Atrioventricular Block

Genetic Tests for Third-Degree Atrioventricular Block

Genetic tests related to Third-Degree Atrioventricular Block:

# Genetic test Affiliating Genes
1 Third Degree Atrioventricular Block 29

Anatomical Context for Third-Degree Atrioventricular Block

MalaCards organs/tissues related to Third-Degree Atrioventricular Block:

41
Heart, Testes, Prostate, B Cells, Retina

Publications for Third-Degree Atrioventricular Block

Articles related to Third-Degree Atrioventricular Block:

(show all 38)
# Title Authors Year
1
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
2
Swallow presyncope in an athletic patient caused by third-degree atrioventricular block. ( 29202647 )
2017
3
Electrocardiographic, echocardiographic, and left atrial strain imaging features of a dog with atrial flutter and third-degree atrioventricular block. ( 28943125 )
2017
4
Third-degree atrioventricular block: tip of the iceberg of a systemic disease. ( 28204445 )
2017
5
Vagal third-degree atrioventricular block in a highly trained endurance athlete. ( 28430941 )
2017
6
Third-Degree Atrioventricular Block and Collapse Associated with Eosinophilic Myocarditis in a Horse. ( 28295606 )
2017
7
Amiodarone-Induced Third Degree Atrioventricular Block and Extreme QT Prolongation Generating Torsade Des Pointes in Paroxysmal Atrial Fibrillation. ( 28496937 )
2016
8
New-onset third-degree atrioventricular block because of autoimmune-induced myositis under treatment with anti-programmed cell death-1 (nivolumab) for metastatic melanoma. ( 27977496 )
2016
9
Evaluation of cardiac function by pacing at different right ventricular sites in patients with third-degree atrioventricular block using Doppler ultrasound. ( 26221220 )
2015
10
Swallow syncope caused by third-degree atrioventricular block. ( 26508117 )
2015
11
The frequency of type 2 second-degree and third-degree atrioventricular block induced by blunt chest trauma in the emergency department: A multicenter study. ( 26033652 )
2015
12
Myocardial infarction, symptomatic third degree atrioventricular block and pulmonary embolism caused by thalidomide: a case report. ( 26681197 )
2015
13
Second-degree atrioventricular block type II and third-degree atrioventricular block requiring cardiac pacing after tooth extraction. ( 25914824 )
2015
14
ECG of the Month. Third degree atrioventricular block. ( 24739111 )
2014
15
Analysis of the atrial repolarization wave in dogs with third-degree atrioventricular block. ( 24370246 )
2014
16
Third-degree atrioventricular block following commotio cordis. ( 24047496 )
2013
17
Third-degree atrioventricular block in an adult with a giant cardiac fibroma. ( 23547182 )
2013
18
Simultaneous pheochromocytoma and third-degree atrioventricular block in 2 dogs. ( 24102992 )
2013
19
Third degree atrioventricular block associated with treatment with rivastigmine transdermal patch. ( 23610582 )
2013
20
Traumatic tricuspid valve rupture presenting as third-degree atrioventricular block. ( 23777772 )
2013
21
Acquired Gerbode defect and third-degree atrioventricular block secondary to vehicular trauma in a dog. ( 24304841 )
2013
22
Unusual diagnosis of a persistent third-degree atrioventricular block during anesthesia in a "healthy" pediatric patient. ( 22412781 )
2012
23
Left ventricular-right atrial communication with third-degree atrioventricular block after thoracic trauma. ( 21621364 )
2012
24
Hyperkalemia secondary to renal hypoperfusion in a dog with third-degree atrioventricular block. ( 22765053 )
2012
25
Cardiac tamponade and paroxysmal third-degree atrioventricular block revealing a primary cardiac non-Hodgkin large B-cell lymphoma of the right ventricle: a case report. ( 21892927 )
2011
26
Third-degree atrioventricular block in an adolescent following acute alcohol intoxication. ( 22679160 )
2011
27
Aortic dissection and third-degree atrioventricular block in a patient with a hypertensive crisis. ( 18174773 )
2008
28
Gerbode type defect and third degree atrioventricular block in association with bacterial endocarditis in a dog. ( 19010115 )
2008
29
Permanent third-degree atrioventricular block as clinical presentation of an intracardiac bronchogenic cyst. ( 18326510 )
2008
30
Documented transient third-degree atrioventricular block and asystole in a child with familial dysautonomia. ( 17851632 )
2008
31
Third-degree atrioventricular block in a horse secondary to rattlesnake envenomation. ( 18371038 )
2008
32
ECG of the Month. Atrial Fibrillation with third-degree atrioventricular block (AVB) and a slow ventricular escape rhythm that was coupled with ventricular premature contractions. ( 18518804 )
2008
33
Third degree atrioventricular block and accelerated idioventricular rhythm associated with a heart base chemodectoma in a syncopal Rottweiler. ( 18045349 )
2007
34
Third degree atrioventricular block and sudden death secondary to acute myocarditis in a dog. ( 17689470 )
2007
35
[Exploration of a third degree atrioventricular block by standard echocardiography, tissue Doppler imaging, and treatment with a cardiac pacemaker in a German wire-haired pointer]. ( 14994485 )
2004
36
Effect of cilostazol on the ventricular escape rate and neurohumoral factors in patients with third-degree atrioventricular block. ( 12684307 )
2003
37
Transient third-degree atrioventricular block in a 4-year-old child with familial dysautonomia. ( 1603720 )
1992
38
Third degree atrioventricular block, chronic progressive external ophthalmoplegia and pigmentary degeneration of retina. Case report and survey of the literature. ( 626112 )
1978

Variations for Third-Degree Atrioventricular Block

Expression for Third-Degree Atrioventricular Block

Search GEO for disease gene expression data for Third-Degree Atrioventricular Block.

Pathways for Third-Degree Atrioventricular Block

Pathways related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.37 HCN4 KCNE2

GO Terms for Third-Degree Atrioventricular Block

Cellular components related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ribonucleoprotein complex GO:1990904 8.62 TRIM21 TROVE2

Biological processes related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of heart rate by cardiac conduction GO:0086091 8.62 HCN4 KCNE2

Molecular functions related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.16 HCN4 KCNE2
2 potassium channel activity GO:0005267 8.96 HCN4 KCNE2
3 voltage-gated potassium channel activity GO:0005249 8.62 HCN4 KCNE2

Sources for Third-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....