MCID: THR099
MIFTS: 40

Third-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Third-Degree Atrioventricular Block

MalaCards integrated aliases for Third-Degree Atrioventricular Block:

Name: Third-Degree Atrioventricular Block 12 15
Third Degree Atrioventricular Block 30
Complete Atrioventricular Block 74
Complete Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050823
ICD10 34 I44.2
UMLS 74 C0151517

Summaries for Third-Degree Atrioventricular Block

Disease Ontology : 12 An atrioventricular block that is characterized by bradycardia, hypotension, hemodynamic instability and complete dissociation between P waves and QRS complexes on electrocardiogram caused when conduction fails to propagate from atria to ventricles.

MalaCards based summary : Third-Degree Atrioventricular Block, also known as third degree atrioventricular block, is related to atrioventricular block and syncope. An important gene associated with Third-Degree Atrioventricular Block is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Phase 0 - rapid depolarisation and Antiarrhythmic Pathway, Pharmacodynamics. The drugs Estradiol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and prostate.

Wikipedia : 77 Third-degree atrioventricular block (AV block), also known as complete heart block, is a medical... more...

Related Diseases for Third-Degree Atrioventricular Block

Diseases related to Third-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 30.5 HCN4 KCNE2 NPPB SCN5A
2 syncope 30.2 NPPB SCN5A
3 cardiac arrest 29.4 NPPB SCN5A
4 atrial fibrillation 29.4 HCN4 KCNE2 NPPB SCN5A
5 long qt syndrome 29.2 HCN4 KCNE2 SCN5A
6 heart disease 28.9 HCN4 KCNE2 NPPB SCN5A
7 myocardial infarction 10.4
8 neuropathy, hereditary sensory and autonomic, type iii 10.2
9 second-degree atrioventricular block 10.2
10 myocarditis 10.2
11 dysautonomia 10.2
12 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1 10.1
13 myositis 10.1
14 pheochromocytoma 10.1
15 myasthenia gravis 10.1
16 nasopharyngeal carcinoma 10.1
17 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2 10.1
18 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 10.1
19 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4 10.1
20 acute myocardial infarction 10.1
21 b-cell lymphomas 10.1
22 congestive heart failure 10.1
23 diabetes mellitus 10.1
24 fibroma 10.1
25 lymphoma 10.1
26 endocarditis 10.1
27 cardiac tamponade 10.1
28 chagas disease 10.1
29 graves' disease 10.1
30 chronic progressive external ophthalmoplegia 10.1
31 melanoma 10.1
32 acute myocarditis 10.1
33 pulmonary embolism 10.1
34 rere-related disorders 10.1
35 baroreflex failure 10.1
36 bronchogenic cyst 10.1
37 myasthenia gravis congenital 10.1
38 pure autonomic failure 10.1
39 cardiogenic shock 10.1
40 schizoaffective disorder 10.1
41 first-degree atrioventricular block 10.0 DSG4 SCN5A
42 wolff-parkinson-white syndrome 9.9 NPPB PRKAG2
43 left bundle branch hemiblock 9.9 NPPB SCN5A
44 familial sick sinus syndrome 9.9 HCN4 SCN5A
45 progressive familial heart block, type ia 9.9
46 cardiac conduction defect 9.9
47 multiple sclerosis 9.9
48 muscular dystrophy, duchenne type 9.9
49 infective endocarditis 9.9
50 lyme disease 9.9

Comorbidity relations with Third-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 30)


Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Atrioventricular Block
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Dressler's Syndrome
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Kidney Disease Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Monocular Esotropia
Peripheral Vascular Disease Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sinoatrial Node Disease
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Third-Degree Atrioventricular Block:



Diseases related to Third-Degree Atrioventricular Block

Symptoms & Phenotypes for Third-Degree Atrioventricular Block

Drugs & Therapeutics for Third-Degree Atrioventricular Block

Drugs for Third-Degree Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1 50-28-2 5757
2
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
3
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
4
Polyestradiol phosphate Approved Phase 4,Phase 1 28014-46-2
5
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
6
Moxifloxacin Approved, Investigational Phase 4,Phase 1 354812-41-2, 151096-09-2 152946
7
Norgestimate Approved, Investigational Phase 4,Phase 1 35189-28-7 6540478
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
10 Contraceptive Agents Phase 4,Phase 1
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Contraceptives, Oral Phase 4,Phase 1
13 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
14 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 1
15 Anti-Infective Agents, Urinary Phase 4,Phase 3
16 Estradiol 17 beta-cypionate Phase 4,Phase 1
17 Estradiol 3-benzoate Phase 4,Phase 1
18 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 1
19 Contraceptives, Oral, Combined Phase 4,Phase 1
20 Renal Agents Phase 4,Phase 3
21
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
22
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
23
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 439542 10909430
24
Polymyxin B Approved, Vet_approved Phase 3 1404-26-8
25
leucovorin Approved Phase 3 58-05-9 6006 143
26
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
27
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
28
Adenosine Approved, Investigational Phase 3,Phase 2 58-61-7 60961
29
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
30
Aripiprazole Approved, Investigational Phase 3 129722-12-9 60795
31
rituximab Approved Phase 3 174722-31-7 10201696
32
Regadenoson Approved, Investigational Phase 3 313348-27-5 219024
33
Digoxin Approved Phase 3 20830-75-5 30322 2724385
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
35
Binodenoson Investigational Phase 3 144348-08-3
36 Anti-Arrhythmia Agents Phase 3,Phase 1
37 Neurotransmitter Agents Phase 3,Phase 2
38 Peripheral Nervous System Agents Phase 3,Phase 1
39 Cardiotonic Agents Phase 3
40 Protective Agents Phase 3
41 Anti-Infective Agents, Local Phase 3
42 Clindamycin palmitate Phase 3
43 Clindamycin phosphate Phase 3
44 Antitubercular Agents Phase 3
45 Antibiotics, Antitubercular Phase 3
46 Polymyxins Phase 3
47 Nucleic Acid Synthesis Inhibitors Phase 3
48 Immunologic Factors Phase 3,Early Phase 1
49 Antimetabolites, Antineoplastic Phase 3
50 Antineoplastic Agents, Hormonal Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Syncope: Pacing or Recording in the Later Years Unknown status NCT01423994 Phase 4
2 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Unknown status NCT02482844 Phase 4
3 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
4 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
5 Catheter Evaluation for Endocardial Ablation in Patients With Typical Atrial Flutter Completed NCT00318565 Phase 4
6 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
7 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
8 First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) Unknown status NCT00392054 Phase 3 Conventional Antiarrhythmic Drug Therapy
9 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
10 Cardiac Sarcoidosis Randomized Trial Recruiting NCT03593759 Phase 3 Prednisone;Methotrexate
11 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3 binodenoson;adenosine
12 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3 binodenoson;adenosine
13 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
14 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
15 A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT) Completed NCT01618669 Phase 3 Regadenoson
16 Digoxin Short Term Treatment Assessment Randomized Trial in AHF Recruiting NCT02544815 Phase 3 Digoxin;Placebo
17 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2 Hydroxychloroquine
18 Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration Completed NCT01570790 Phase 1, Phase 2 Combretastatin A-4 phosphate;Combretastatin A-4 Phosphate;Combretastatin A-4 Phosphate
19 The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid Cardiomyopathy Completed NCT00694161 Phase 2 Fx-1006A
20 Study to Investigate the Effects of Orteronel on the QT/QTc Interval in Patients With Metastatic Castration-Resistant Prostate Cancer Completed NCT01549951 Phase 2 Orteronel+Prednisone
21 Multiple Dose Study in Heart Failure of BAY 1067197 Completed NCT02040233 Phase 2 BAY1067197 (10 mg);BAY1067197;Placebo (10 mg);Placebo
22 Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps Completed NCT03102190 Phase 1 Verapamil Hydrochloride Intranasal
23 The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) at Doses up to 80 Micrograms/Hour (mcg/hr) and Naltrexone on Electrocardiogram (ECG) Intervals in Healthy Volunteers Completed NCT01999114 Phase 1 Buprenorphine transdermal patch;Naltrexone tablet;Placebos (for TDS and for naltrexone and for moxifloxacin);Moxifloxacin tablet
24 Study Assessing the Effects of Darunavir/Ritonavir or Lopinavir/Ritonavir on the Pharmacokinetics of Daclatasvir in Healthy Participants Completed NCT02159352 Phase 1 Daclatasvir;Darunavir;Ritonavir;Lopinavir/Ritonavir
25 Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder Completed NCT01423916 Phase 1 OPC-34712 (4mg);Moxifloxacin;OPC-34712 (12mg);Placebo
26 Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Completed NCT02050802 Phase 1 Moxifloxacin 400 mg;Macitentan 10 mg;Macitentan 30 mg
27 Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms Unknown status NCT02881671
28 Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block Unknown status NCT01477658
29 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
30 Prognostic Accuracy of Coronary CT and Dobutamine Stress Echocardiography in Patient Undergoing Non-cardiac Surgery Unknown status NCT02250963
31 Evaluation of Atrial Fibrillation Occurrence in Sick Sinus and Complete Atrioventricular Block Patients After Pacemaker Implantation (AF-pacemaker Study) Recruiting NCT03303872
32 Exercise in Chronically Paced Children Completed NCT00374608
33 Microfidelity (MIFI) Ablation Technology Versus Standard Ablation Catheter for Atrioventricular Nodal Ablation Recruiting NCT03114124 Not Applicable
34 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717 Not Applicable
35 Electrophysiologic HV-interval as a Predicor for Permanent Pacemaker Implantation After TAVI Completed NCT01801098
36 Preventive IVIG Therapy for Congenital Heart Block Completed NCT00460928 Early Phase 1 intravenous immune globulin (IVIG)
37 Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study Recruiting NCT02153307 Not Applicable
38 Study of the Loss of AV Synchrony at Maximum Exercise Not yet recruiting NCT03859167
39 PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular Pacing Completed NCT00461734 Not Applicable
40 Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device Recruiting NCT02559011
41 Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome. Completed NCT01768949 Not Applicable
42 Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement Recruiting NCT03163836
43 Comparison of 24-hour Holter Monitoring Versus 14-day Continuous ECG Patch Monitoring EZYPRO Recruiting NCT03602742 Not Applicable
44 Medtronic CoreValve REDO Study Completed NCT01051310 Not Applicable
45 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Recruiting NCT03118440 Not Applicable
46 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Recruiting NCT03118427 Not Applicable
47 His Bundle Pacing in Bradycardia and Heart Failure Recruiting NCT03008291
48 Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures Completed NCT00771927 Lacosamide
49 Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS Recruiting NCT03094143 Not Applicable
50 Plasma Glucagon-like Peptide-1 Levels and In-hospital Complications in ST-segment Elevation Myocardial Infarction Completed NCT03314844

Search NIH Clinical Center for Third-Degree Atrioventricular Block

Genetic Tests for Third-Degree Atrioventricular Block

Genetic tests related to Third-Degree Atrioventricular Block:

# Genetic test Affiliating Genes
1 Third Degree Atrioventricular Block 30

Anatomical Context for Third-Degree Atrioventricular Block

MalaCards organs/tissues related to Third-Degree Atrioventricular Block:

42
Heart, Testes, Prostate, B Cells, Retina, Atrioventricular Node

Publications for Third-Degree Atrioventricular Block

Articles related to Third-Degree Atrioventricular Block:

(show top 50) (show all 68)
# Title Authors Year
1
Third-degree atrioventricular block followed by syncope, labile hypertension, and orthostatic hypotension in a patient with nasopharyngeal cancer: baroreflex failure. ( 30038845 )
2018
2
Prognostic Implications of QRS Duration in Third-Degree Atrioventricular Block Patients with Heart Failure Treated with Cardiac Resynchronization Therapy. ( 30369567 )
2018
3
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
4
Swallow presyncope in an athletic patient caused by third-degree atrioventricular block. ( 29202647 )
2017
5
Electrocardiographic, echocardiographic, and left atrial strain imaging features of a dog with atrial flutter and third-degree atrioventricular block. ( 28943125 )
2017
6
Third-degree atrioventricular block: tip of the iceberg of a systemic disease. ( 28204445 )
2017
7
Vagal third-degree atrioventricular block in a highly trained endurance athlete. ( 28430941 )
2017
8
Third-Degree Atrioventricular Block and Collapse Associated with Eosinophilic Myocarditis in a Horse. ( 28295606 )
2017
9
Amiodarone-Induced Third Degree Atrioventricular Block and Extreme QT Prolongation Generating Torsade Des Pointes in Paroxysmal Atrial Fibrillation. ( 28496937 )
2016
10
New-onset third-degree atrioventricular block because of autoimmune-induced myositis under treatment with anti-programmed cell death-1 (nivolumab) for metastatic melanoma. ( 27977496 )
2016
11
Evaluation of cardiac function by pacing at different right ventricular sites in patients with third-degree atrioventricular block using Doppler ultrasound. ( 26221220 )
2015
12
Swallow syncope caused by third-degree atrioventricular block. ( 26508117 )
2015
13
The frequency of type 2 second-degree and third-degree atrioventricular block induced by blunt chest trauma in the emergency department: A multicenter study. ( 26033652 )
2015
14
Myocardial infarction, symptomatic third degree atrioventricular block and pulmonary embolism caused by thalidomide: a case report. ( 26681197 )
2015
15
Second-degree atrioventricular block type II and third-degree atrioventricular block requiring cardiac pacing after tooth extraction. ( 25914824 )
2015
16
ECG of the Month. Third degree atrioventricular block. ( 24739111 )
2014
17
Analysis of the atrial repolarization wave in dogs with third-degree atrioventricular block. ( 24370246 )
2014
18
Third-degree atrioventricular block following commotio cordis. ( 24047496 )
2013
19
Third-degree atrioventricular block in an adult with a giant cardiac fibroma. ( 23547182 )
2013
20
Simultaneous pheochromocytoma and third-degree atrioventricular block in 2 dogs. ( 24102992 )
2013
21
Third degree atrioventricular block associated with treatment with rivastigmine transdermal patch. ( 23610582 )
2013
22
Traumatic tricuspid valve rupture presenting as third-degree atrioventricular block. ( 23777772 )
2013
23
Acquired Gerbode defect and third-degree atrioventricular block secondary to vehicular trauma in a dog. ( 24304841 )
2013
24
Unusual diagnosis of a persistent third-degree atrioventricular block during anesthesia in a "healthy" pediatric patient. ( 22412781 )
2012
25
Left ventricular-right atrial communication with third-degree atrioventricular block after thoracic trauma. ( 21621364 )
2012
26
Hyperkalemia secondary to renal hypoperfusion in a dog with third-degree atrioventricular block. ( 22765053 )
2012
27
Cardiac tamponade and paroxysmal third-degree atrioventricular block revealing a primary cardiac non-Hodgkin large B-cell lymphoma of the right ventricle: a case report. ( 21892927 )
2011
28
Third-degree atrioventricular block in an adolescent following acute alcohol intoxication. ( 22679160 )
2011
29
Aortic dissection and third-degree atrioventricular block in a patient with a hypertensive crisis. ( 18174773 )
2008
30
Gerbode type defect and third degree atrioventricular block in association with bacterial endocarditis in a dog. ( 19010115 )
2008
31
Permanent third-degree atrioventricular block as clinical presentation of an intracardiac bronchogenic cyst. ( 18326510 )
2008
32
Documented transient third-degree atrioventricular block and asystole in a child with familial dysautonomia. ( 17851632 )
2008
33
Third-degree atrioventricular block in a horse secondary to rattlesnake envenomation. ( 18371038 )
2008
34
ECG of the Month. Atrial Fibrillation with third-degree atrioventricular block (AVB) and a slow ventricular escape rhythm that was coupled with ventricular premature contractions. ( 18518804 )
2008
35
Third degree atrioventricular block and accelerated idioventricular rhythm associated with a heart base chemodectoma in a syncopal Rottweiler. ( 18045349 )
2007
36
Third degree atrioventricular block and sudden death secondary to acute myocarditis in a dog. ( 17689470 )
2007
37
Third-degree atrioventricular block and unusual superior vena cava abnormality. ( 17667042 )
2007
38
Third-degree atrioventricular block in 21 cats (1997-2004). ( 16496928 )
2006
39
Signalment, clinical signs, and prognostic indicators associated with high-grade second- or third-degree atrioventricular block in dogs: 124 cases (January 1, 1997-December 31, 1997). ( 16740072 )
2006
40
Thalidomide-induced symptomatic third-degree atrioventricular block. ( 16773277 )
2006
41
Temporary third-degree atrioventricular block in a case of apical ballooning syndrome. ( 16793149 )
2006
42
Pacemaker implantation in a ferret (Mustela putorius furo) with third-degree atrioventricular block. ( 16931390 )
2006
43
Increased prevalence of third-degree atrioventricular block in patients with type II diabetes mellitus. ( 16236932 )
2005
44
Atrial T waves (TA) revealed by third-degree atrioventricular block. ( 16330926 )
2005
45
Kiss of the Benchuca--Chagas' disease presenting with transient third-degree atrioventricular block. ( 16450547 )
2005
46
Temporary biventricular pacing in a patient with subacute myocardial infarction, cardiogenic shock, and third-degree atrioventricular block. ( 15851278 )
2005
47
[Exploration of a third degree atrioventricular block by standard echocardiography, tissue Doppler imaging, and treatment with a cardiac pacemaker in a German wire-haired pointer]. ( 14994485 )
2004
48
Effect of cilostazol on the ventricular escape rate and neurohumoral factors in patients with third-degree atrioventricular block. ( 12684307 )
2003
49
Successful use of an acceleration rate response pacemaker with a transvenous steroid-eluting screw-in lead for third-degree atrioventricular block in a labrador retriever. ( 14600348 )
2003
50
Desmin-storage disease and third degree atrioventricular block. ( 10646963 )
2000

Variations for Third-Degree Atrioventricular Block

Expression for Third-Degree Atrioventricular Block

Search GEO for disease gene expression data for Third-Degree Atrioventricular Block.

Pathways for Third-Degree Atrioventricular Block

Pathways related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 KCNE2 SCN5A
2 10.55 HCN4 KCNE2 SCN5A

GO Terms for Third-Degree Atrioventricular Block

Biological processes related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.54 HCN4 KCNE2 SCN5A
2 sodium ion transmembrane transport GO:0035725 9.49 HCN4 SCN5A
3 potassium ion import across plasma membrane GO:1990573 9.48 HCN4 KCNE2
4 regulation of heart rate GO:0002027 9.46 HCN4 SCN5A
5 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.43 KCNE2 SCN5A
6 ventricular cardiac muscle cell action potential GO:0086005 9.4 KCNE2 SCN5A
7 cardiac muscle cell action potential involved in contraction GO:0086002 9.32 KCNE2 SCN5A
8 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.26 HCN4 SCN5A
9 SA node cell action potential GO:0086015 9.16 HCN4 SCN5A
10 membrane depolarization during SA node cell action potential GO:0086046 8.96 HCN4 SCN5A
11 regulation of heart rate by cardiac conduction GO:0086091 8.8 HCN4 KCNE2 SCN5A

Molecular functions related to Third-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium channel activity GO:0005267 9.32 HCN4 KCNE2
2 voltage-gated potassium channel activity GO:0005249 9.26 HCN4 KCNE2
3 sodium channel activity GO:0005272 9.16 HCN4 SCN5A
4 voltage-gated sodium channel activity GO:0005248 8.96 HCN4 SCN5A
5 voltage-gated ion channel activity GO:0005244 8.8 HCN4 KCNE2 SCN5A

Sources for Third-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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