Thoracic Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm ¹² ¹⁵

Benign Neoplasm of Thorax ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060097

UMLS ⁷³ C0346440

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Summaries for Thoracic Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to vulvar syringoma and lung leiomyoma. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include the thoracic cavity, and related phenotypes are cardiovascular system and digestive/alimentary

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Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar syringoma	11.0	ESR1 PGR
2	lung leiomyoma	10.9	ESR1 PGR
3	scirrhous adenocarcinoma	10.9	ERBB2 PGR
4	breast apocrine carcinoma	10.9	ERBB2 PGR
5	vulvar benign neoplasm	10.9	ESR1 PGR
6	vulvar leiomyoma	10.9	ESR1 PGR
7	breast mucoepidermoid carcinoma	10.9	ERBB2 PGR
8	breast metaplastic carcinoma	10.9	ERBB2 PGR
9	intracystic papillary adenoma	10.9	ERBB2 PGR
10	progesterone-receptor negative breast cancer	10.9	ERBB2 PGR
11	endometrium carcinoma in situ	10.9	PGR TP53
12	progesterone resistance	10.9	ESR1 PGR
13	cribriform carcinoma	10.9	ESR1 PGR
14	comedo carcinoma	10.9	ERBB2 ESR1
15	endometrial squamous cell carcinoma	10.8	ESR1 PGR
16	endometrial clear cell adenocarcinoma	10.8	ESR1 TP53
17	bizarre leiomyoma	10.8	MED12 PGR
18	endometrial mucinous adenocarcinoma	10.8	ESR1 PGR
19	adenoid basal cell carcinoma	10.8	ESR1 PGR
20	gender identity disorder	10.8	ESR1 PGR
21	gallbladder squamous cell carcinoma	10.8	ERBB2 TP53
22	gastric papillary adenocarcinoma	10.8	ERBB2 TP53
23	female reproductive endometrioid cancer	10.8	PGR TP53
24	olfactory groove meningioma	10.8	PGR TP53
25	uterine corpus serous adenocarcinoma	10.8	ERBB2 TP53
26	estrogen excess	10.7	ESR1 PGR
27	mammographic density	10.7	ESR1 PGR
28	non-proliferative fibrocystic change of the breast	10.7	ERBB2 TP53
29	papillary serous adenocarcinoma	10.7	PGR TP53
30	retinitis pigmentosa 47	10.7	ESR1 PGR
31	glassy cell carcinoma of the cervix	10.7	ERBB2 ESR1 PGR
32	breast medullary carcinoma	10.7	ERBB2 ESR1 PGR
33	breast scirrhous carcinoma	10.7	ERBB2 ESR1 PGR
34	progesterone-receptor positive breast cancer	10.7	ERBB2 ESR1 PGR
35	pleomorphic adenoma carcinoma	10.7	ERBB2 TP53
36	apocrine adenocarcinoma	10.7	ERBB2 ESR1 PGR
37	breast adenoid cystic carcinoma	10.7	ERBB2 ESR1 PGR
38	luminal breast carcinoma	10.7	ERBB2 ESR1 PGR
39	inflammatory breast carcinoma	10.7	ERBB2 ESR1 PGR
40	mammary paget's disease	10.7	ERBB2 ESR1 PGR
41	bilateral breast cancer	10.7	ERBB2 ESR1 PGR
42	tubular adenocarcinoma	10.7	ERBB2 ESR1 PGR
43	anterior cranial fossa meningioma	10.7	PGR TP53
44	estrogen-receptor negative breast cancer	10.6	ERBB2 ESR1 PGR
45	glioma susceptibility 1	10.6	ERBB2 TP53
46	breast malignant phyllodes tumor	10.6	PGR PTS TP53
47	vestibular gland benign neoplasm	10.6	ESR1 PGR TP53
48	bartholin's gland adenoma	10.6	ESR1 PGR TP53
49	fallopian tube endometrioid adenocarcinoma	10.6	ERBB2 MME
50	uterine benign neoplasm	10.6	ESR1 MED12 PGR

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:

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Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.01	PLVAP ESR1 PTS TP53 MED12 PGR
2	digestive/alimentary	MP:0005381	9.97	ESR1 PTS KRT14 TP53 KRT15 ERBB2
3	homeostasis/metabolism	MP:0005376	9.96	PLVAP ESR1 PTS KRT14 KRT15 TP53
4	endocrine/exocrine gland	MP:0005379	9.92	PLVAP ESR1 PTS KRT14 TP53 PGR
5	integument	MP:0010771	9.81	PTS KRT14 TP53 MME PGR CD34
6	limbs/digits/tail	MP:0005371	9.43	PLVAP ESR1 TP53 MED12 PGR ERBB2
7	neoplasm	MP:0002006	9.1	ESR1 KRT14 TP53 CD34 PGR ERBB2

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Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

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Genetic Tests for Thoracic Benign Neoplasm

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Anatomical Context for Thoracic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

¹⁹

The Thoracic Cavity

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Publications for Thoracic Benign Neoplasm

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Genes for Thoracic Benign Neoplasm

Genes related to Thoracic Benign Neoplasm (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	16.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	16.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	ESR1	Estrogen Receptor 1	Protein Coding	15.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	15.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PLVAP	Plasmalemma Vesicle Associated Protein	Protein Coding	15.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MED12	Mediator Complex Subunit 12	Protein Coding	15.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	TP53	Tumor Protein P53	Protein Coding	15.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	RHOXF2	Rhox Homeobox Family Member 2	Protein Coding	15.01	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	KRT14	Keratin 14	Protein Coding	14.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	KRT15	Keratin 15	Protein Coding	14.66	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	MME	Membrane Metalloendopeptidase	Protein Coding	14.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	PIP	Prolactin Induced Protein	Protein Coding	5.59	DISEASES inferred ¹⁵
13	CD34	CD34 Molecule	Protein Coding	5.46	DISEASES inferred ¹⁵
14	ING5	Inhibitor Of Growth Family Member 5	Protein Coding	5.09	DISEASES inferred ¹⁵
15	ODF4	Outer Dense Fiber Of Sperm Tails 4	Protein Coding	4.8	DISEASES inferred ¹⁵

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Variations for Thoracic Benign Neoplasm

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Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

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Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Thyroid hormone signaling pathway ³⁷	11.2	ESR1 MED12 TP53
2	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	10.83	ERBB2 ESR1 PGR

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GO Terms for Thoracic Benign Neoplasm

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.32	ESR1 MED12
2	replicative senescence	GO:0090399	9.26	MME TP53
3	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.16	ESR1 TP53
4	positive regulation of gene expression	GO:0010628	9.02	CD34 ERBB2 PIP RHOXF2 TP53
5	paracrine signaling	GO:0038001	8.96	CD34 PGR

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.47	ERBB2 ESR1 ING5 KRT14 KRT15 MED12
2	transcription factor binding	GO:0008134	9.26	CD34 ESR1 MED12 TP53

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