MCID: THR011
MIFTS: 28

Thoracic Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm 12 15
Benign Neoplasm of Thorax 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060097
UMLS 74 C0346440

Summaries for Thoracic Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to breast benign neoplasm and retinitis pigmentosa 47. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include the thoracic cavity, and related phenotypes are cardiovascular system and cellular

Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 breast benign neoplasm 28.7 CD34 ERBB2 ESR1 KRT14 KRT5 MED12
2 retinitis pigmentosa 47 10.5 ESR1 PGR
3 mammographic density 10.5 ESR1 PGR
4 gender identity disorder 10.5 ESR1 PGR
5 estrogen excess 10.5 ESR1 PGR
6 endometrial mucinous adenocarcinoma 10.5 ESR1 PGR
7 adenoid basal cell carcinoma 10.5 ESR1 PGR
8 retroperitoneal leiomyosarcoma 10.5 PGR PTS
9 multiple enchondromatosis, maffucci type 10.5 IDH1 IDH2
10 intraductal papilloma 10.5 IDH1 IDH2
11 adult astrocytic tumour 10.5 IDH1 IDH2
12 pilocytic astrocytoma of cerebellum 10.5 IDH1 IDH2
13 spindle cell hemangioma 10.5 IDH1 IDH2
14 periosteal chondrosarcoma 10.5 IDH1 IDH2
15 vestibular gland benign neoplasm 10.5 ESR1 PGR
16 bartholin's gland adenoma 10.5 ESR1 PGR
17 scirrhous adenocarcinoma 10.4 ERBB2 PGR
18 vulvar syringoma 10.4 ESR1 PGR
19 lung leiomyoma 10.4 ESR1 PGR
20 breast apocrine carcinoma 10.4 ERBB2 PGR
21 vulvar benign neoplasm 10.4 ESR1 PGR
22 vulvar leiomyoma 10.4 ESR1 PGR
23 interval angle-closure glaucoma 10.4 IDH1 IDH2
24 intracystic papillary adenoma 10.4 ERBB2 PGR
25 adult oligodendroglioma 10.4 IDH1 IDH2
26 enchondroma 10.4 IDH1 IDH2
27 papillary serous adenocarcinoma 10.4 PGR TP53
28 anterior cranial fossa meningioma 10.4 PGR TP53
29 progesterone-receptor negative breast cancer 10.4 ERBB2 PGR
30 bartholin's gland benign neoplasm 10.4 ESR1 PGR
31 lymphoepithelioma-like thymic carcinoma 10.4 IDH1 KRT5
32 comedo carcinoma 10.4 ERBB2 ESR1
33 uterine corpus serous adenocarcinoma 10.4 ERBB2 TP53
34 mixed glioma 10.3 IDH1 TP53
35 endometrium carcinoma in situ 10.3 PGR TP53
36 glassy cell carcinoma of the cervix 10.3 PGR ESR1 ERBB2
37 epidermolysis bullosa simplex, generalized 10.3 KRT14 KRT5
38 epidermolysis bullosa simplex with mottled pigmentation 10.3 KRT14 KRT5
39 bizarre leiomyoma 10.3 MED12 PGR
40 breast medullary carcinoma 10.3 ERBB2 ESR1 PGR
41 breast scirrhous carcinoma 10.3 ERBB2 ESR1 PGR
42 progesterone-receptor positive breast cancer 10.3 ERBB2 ESR1 PGR
43 odontoma 10.3 KRT14 KRT5
44 breast adenoid cystic carcinoma 10.3 ERBB2 ESR1 PGR
45 inflammatory breast carcinoma 10.3 ERBB2 ESR1 PGR
46 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
47 luminal breast carcinoma 10.3 ERBB2 ESR1 PGR
48 mammary paget's disease 10.3 ERBB2 ESR1 PGR
49 tubular adenocarcinoma 10.3 ERBB2 ESR1 PGR
50 leiomyomatosis 10.3 ESR1 MED12 PGR

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:



Diseases related to Thoracic Benign Neoplasm

Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 ERBB2 ESR1 IDH2 MED12 PGR PIP
2 cellular MP:0005384 10.16 CD34 ERBB2 ESR1 KRT14 MED12 PGR
3 growth/size/body region MP:0005378 10.16 ERBB2 ESR1 IDH1 KRT14 KRT5 MED12
4 endocrine/exocrine gland MP:0005379 10.13 ERBB2 ESR1 KRT14 PGR PIP PLVAP
5 digestive/alimentary MP:0005381 10.1 ERBB2 ESR1 KRT14 KRT5 PIP PLVAP
6 homeostasis/metabolism MP:0005376 10.1 CD34 ERBB2 ESR1 IDH1 KRT14 PGR
7 hematopoietic system MP:0005397 10.09 CD34 ESR1 IDH1 KRT14 PGR PIP
8 immune system MP:0005387 10.02 CD34 ESR1 IDH1 KRT14 PGR PIP
9 integument MP:0010771 9.97 CD34 ERBB2 ESR1 KRT14 KRT5 PGR
10 mortality/aging MP:0010768 9.9 ERBB2 ESR1 IDH1 KRT14 KRT5 MED12
11 limbs/digits/tail MP:0005371 9.8 ERBB2 ESR1 KRT5 MED12 PGR PLVAP
12 neoplasm MP:0002006 9.5 CD34 ERBB2 ESR1 IDH2 KRT14 PGR
13 respiratory system MP:0005388 9.1 ERBB2 ESR1 IDH1 KRT14 PLVAP TP53

Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

Genetic Tests for Thoracic Benign Neoplasm

Anatomical Context for Thoracic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

20
The Thoracic Cavity

Publications for Thoracic Benign Neoplasm

Variations for Thoracic Benign Neoplasm

Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 ESR1 MED12 TP53
2
Show member pathways
11.47 ERBB2 ESR1 PGR
3 11.05 KRT14 KRT5 TP53
4 10.61 ERBB2 IDH1 TP53
5
Show member pathways
10.27 IDH1 IDH2

GO Terms for Thoracic Benign Neoplasm

Cellular components related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.32 ERBB2 ESR1 IDH1 IDH2 KRT14 KRT5

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 2-oxoglutarate metabolic process GO:0006103 9.46 IDH1 IDH2
2 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 ESR1 MED12
3 hemidesmosome assembly GO:0031581 9.4 KRT14 KRT5
4 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.37 ESR1 TP53
5 positive regulation of gene expression GO:0010628 9.35 CD34 ERBB2 PIP RHOXF2 TP53
6 NADP metabolic process GO:0006739 9.32 IDH1 IDH2
7 paracrine signaling GO:0038001 9.26 CD34 PGR
8 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
9 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 ERBB2 ESR1 IDH1 PGR PTS RHOXF2
2 transcription factor binding GO:0008134 9.56 CD34 ESR1 MED12 TP53
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Thoracic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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