Thoracic Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm ¹² ¹⁵

Benign Neoplasm of Thorax ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060097

UMLS ⁷⁴ C0346440

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Summaries for Thoracic Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to breast benign neoplasm and retinitis pigmentosa 47. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include the thoracic cavity, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)

#	Related Disease	Score	Top Affiliating Genes
1	breast benign neoplasm	28.7	CD34 ERBB2 ESR1 KRT14 KRT5 MED12
2	retinitis pigmentosa 47	10.5	ESR1 PGR
3	mammographic density	10.5	ESR1 PGR
4	gender identity disorder	10.5	ESR1 PGR
5	estrogen excess	10.5	ESR1 PGR
6	endometrial mucinous adenocarcinoma	10.5	ESR1 PGR
7	adenoid basal cell carcinoma	10.5	ESR1 PGR
8	retroperitoneal leiomyosarcoma	10.5	PGR PTS
9	multiple enchondromatosis, maffucci type	10.5	IDH1 IDH2
10	intraductal papilloma	10.5	IDH1 IDH2
11	adult astrocytic tumour	10.5	IDH1 IDH2
12	pilocytic astrocytoma of cerebellum	10.5	IDH1 IDH2
13	spindle cell hemangioma	10.5	IDH1 IDH2
14	periosteal chondrosarcoma	10.5	IDH1 IDH2
15	vestibular gland benign neoplasm	10.5	ESR1 PGR
16	bartholin's gland adenoma	10.5	ESR1 PGR
17	scirrhous adenocarcinoma	10.4	ERBB2 PGR
18	vulvar syringoma	10.4	ESR1 PGR
19	lung leiomyoma	10.4	ESR1 PGR
20	breast apocrine carcinoma	10.4	ERBB2 PGR
21	vulvar benign neoplasm	10.4	ESR1 PGR
22	vulvar leiomyoma	10.4	ESR1 PGR
23	interval angle-closure glaucoma	10.4	IDH1 IDH2
24	intracystic papillary adenoma	10.4	ERBB2 PGR
25	adult oligodendroglioma	10.4	IDH1 IDH2
26	enchondroma	10.4	IDH1 IDH2
27	papillary serous adenocarcinoma	10.4	PGR TP53
28	anterior cranial fossa meningioma	10.4	PGR TP53
29	progesterone-receptor negative breast cancer	10.4	ERBB2 PGR
30	bartholin's gland benign neoplasm	10.4	ESR1 PGR
31	lymphoepithelioma-like thymic carcinoma	10.4	IDH1 KRT5
32	comedo carcinoma	10.4	ERBB2 ESR1
33	uterine corpus serous adenocarcinoma	10.4	ERBB2 TP53
34	mixed glioma	10.3	IDH1 TP53
35	endometrium carcinoma in situ	10.3	PGR TP53
36	glassy cell carcinoma of the cervix	10.3	PGR ESR1 ERBB2
37	epidermolysis bullosa simplex, generalized	10.3	KRT14 KRT5
38	epidermolysis bullosa simplex with mottled pigmentation	10.3	KRT14 KRT5
39	bizarre leiomyoma	10.3	MED12 PGR
40	breast medullary carcinoma	10.3	ERBB2 ESR1 PGR
41	breast scirrhous carcinoma	10.3	ERBB2 ESR1 PGR
42	progesterone-receptor positive breast cancer	10.3	ERBB2 ESR1 PGR
43	odontoma	10.3	KRT14 KRT5
44	breast adenoid cystic carcinoma	10.3	ERBB2 ESR1 PGR
45	inflammatory breast carcinoma	10.3	ERBB2 ESR1 PGR
46	cytogenetically normal acute myeloid leukemia	10.3	IDH1 IDH2
47	luminal breast carcinoma	10.3	ERBB2 ESR1 PGR
48	mammary paget's disease	10.3	ERBB2 ESR1 PGR
49	tubular adenocarcinoma	10.3	ERBB2 ESR1 PGR
50	leiomyomatosis	10.3	ESR1 MED12 PGR

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:

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Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

⁴⁷ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.22	ERBB2 ESR1 IDH2 MED12 PGR PIP
2	cellular	MP:0005384	10.16	CD34 ERBB2 ESR1 KRT14 MED12 PGR
3	growth/size/body region	MP:0005378	10.16	ERBB2 ESR1 IDH1 KRT14 KRT5 MED12
4	endocrine/exocrine gland	MP:0005379	10.13	ERBB2 ESR1 KRT14 PGR PIP PLVAP
5	digestive/alimentary	MP:0005381	10.1	ERBB2 ESR1 KRT14 KRT5 PIP PLVAP
6	homeostasis/metabolism	MP:0005376	10.1	CD34 ERBB2 ESR1 IDH1 KRT14 PGR
7	hematopoietic system	MP:0005397	10.09	CD34 ESR1 IDH1 KRT14 PGR PIP
8	immune system	MP:0005387	10.02	CD34 ESR1 IDH1 KRT14 PGR PIP
9	integument	MP:0010771	9.97	CD34 ERBB2 ESR1 KRT14 KRT5 PGR
10	mortality/aging	MP:0010768	9.9	ERBB2 ESR1 IDH1 KRT14 KRT5 MED12
11	limbs/digits/tail	MP:0005371	9.8	ERBB2 ESR1 KRT5 MED12 PGR PLVAP
12	neoplasm	MP:0002006	9.5	CD34 ERBB2 ESR1 IDH2 KRT14 PGR
13	respiratory system	MP:0005388	9.1	ERBB2 ESR1 IDH1 KRT14 PLVAP TP53

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Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

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Genetic Tests for Thoracic Benign Neoplasm

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Anatomical Context for Thoracic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

²⁰

The Thoracic Cavity

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Publications for Thoracic Benign Neoplasm

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Genes for Thoracic Benign Neoplasm

Genes related to Thoracic Benign Neoplasm (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	16.43	DISEASES inferred ¹⁵
2	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial	Protein Coding	16.31	DISEASES inferred ¹⁵
3	ESR1	Estrogen Receptor 1	Protein Coding	16.06	DISEASES inferred ¹⁵
4	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	16.05	DISEASES inferred ¹⁵
5	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	16.02	DISEASES inferred ¹⁵
6	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic	Protein Coding	15.99	DISEASES inferred ¹⁵
7	MED12	Mediator Complex Subunit 12	Protein Coding	15.56	DISEASES inferred ¹⁵
8	PLVAP	Plasmalemma Vesicle Associated Protein	Protein Coding	15.54	DISEASES inferred ¹⁵
9	KRT14	Keratin 14	Protein Coding	15.28	DISEASES inferred ¹⁵
10	KRT5	Keratin 5	Protein Coding	15.26	DISEASES inferred ¹⁵
11	TP53	Tumor Protein P53	Protein Coding	15.17	DISEASES inferred ¹⁵
12	RHOXF2	Rhox Homeobox Family Member 2	Protein Coding	14.91	DISEASES inferred ¹⁵
13	PIP	Prolactin Induced Protein	Protein Coding	5.34	DISEASES inferred ¹⁵
14	CD34	CD34 Molecule	Protein Coding	5.32	DISEASES inferred ¹⁵
15	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	5.19	DISEASES inferred ¹⁵

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Variations for Thoracic Benign Neoplasm

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Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

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Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Thyroid hormone signaling pathway ³⁸	11.56	ESR1 MED12 TP53
2	Signaling by ERBB4 ⁶⁷ Show member pathways Downregulation of ERBB4 signaling ⁶⁷ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁷	11.47	ERBB2 ESR1 PGR
3	Glucocorticoid receptor regulatory network ¹	11.05	KRT14 KRT5 TP53
4	Central carbon metabolism in cancer ³⁸	10.61	ERBB2 IDH1 TP53
5	Cytosine methylation ¹ Show member pathways TET1,2,3 and TDG demethylate DNA ⁶⁷	10.27	IDH1 IDH2

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GO Terms for Thoracic Benign Neoplasm

Cellular components related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.32	ERBB2 ESR1 IDH1 IDH2 KRT14 KRT5

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	2-oxoglutarate metabolic process	GO:0006103	9.46	IDH1 IDH2
2	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.43	ESR1 MED12
3	hemidesmosome assembly	GO:0031581	9.4	KRT14 KRT5
4	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.37	ESR1 TP53
5	positive regulation of gene expression	GO:0010628	9.35	CD34 ERBB2 PIP RHOXF2 TP53
6	NADP metabolic process	GO:0006739	9.32	IDH1 IDH2
7	paracrine signaling	GO:0038001	9.26	CD34 PGR
8	isocitrate metabolic process	GO:0006102	9.16	IDH1 IDH2
9	glyoxylate cycle	GO:0006097	8.62	IDH1 IDH2

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.7	ERBB2 ESR1 IDH1 PGR PTS RHOXF2
2	transcription factor binding	GO:0008134	9.56	CD34 ESR1 MED12 TP53
3	isocitrate dehydrogenase (NADP+) activity	GO:0004450	8.96	IDH1 IDH2
4	isocitrate dehydrogenase activity	GO:0004448	8.62	IDH1 IDH2

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