MCID: THR011
MIFTS: 27

Thoracic Benign Neoplasm

Categories: Cancer diseases
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Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm 11 14
Benign Neoplasm of Thorax 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0060097
UMLS 71 C0346440

Summaries for Thoracic Benign Neoplasm

Disease Ontology: 11 An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary: Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to peritoneal benign neoplasm and breast benign neoplasm. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Disease and ERK Signaling. Affiliated tissues include thoracic cavity, and related phenotypes are Decreased viability in pancreas lineage and homeostasis/metabolism

Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 615)
# Related Disease Score Top Affiliating Genes
1 peritoneal benign neoplasm 32.4 PGR MED12 ESR1
2 breast benign neoplasm 29.9 TP53 SERPINA3 PRL PRKAR1A PIP PGR
3 chest wall lipoma 11.1
4 axillary lipoma 11.1
5 mediastinum leiomyoma 11.1
6 adult cystic nephroma 10.5 PGR ESR1
7 her2-receptor negative breast cancer 10.5 PGR ERBB2
8 vagina leiomyosarcoma 10.5 PGR ESR1
9 vulvar benign neoplasm 10.5 PGR ESR1
10 pulmonary vein leiomyosarcoma 10.4 PGR CD34
11 mucoepidermoid esophageal carcinoma 10.4 TP53 KRT5
12 leiomyomatosis 10.4 PGR MED12 ESR1
13 vagina leiomyoma 10.4 PGR CD34
14 sebaceous breast carcinoma 10.4 PIP ERBB2
15 progesterone resistance 10.4 PGR ESR1
16 autosomal dominant generalized epidermolysis bullosa simplex, severe form 10.4 KRT5 KRT14
17 lung meningioma 10.4 PGR CD34
18 nipple carcinoma 10.4 PGR ESR1 ERBB2
19 laryngeal mucoepidermoid carcinoma 10.4 KRT14 ERBB2
20 breast mucinous cystadenocarcinoma 10.4 PGR ESR1 ERBB2
21 breast fibroadenosis 10.4 PGR ESR1 ERBB2
22 bulbospinal polio 10.4 PGR ESR1 ERBB2
23 spinal polio 10.4 PGR ESR1 ERBB2
24 glycogen-rich clear cell breast carcinoma 10.4 PGR ESR1 ERBB2
25 breast cystic hypersecretory carcinoma 10.4 PGR ESR1 ERBB2
26 apocrine adenosis of breast 10.4 TP53 ERBB2
27 lung leiomyosarcoma 10.4 KRT5 CD34
28 cervical adenomyoma 10.4 PGR MME
29 papillary hidradenoma 10.4 PIP MED12
30 cervical benign neoplasm 10.4 PGR MME
31 pregnancy adenoma 10.4 PGR KRT5
32 progesterone-receptor negative breast cancer 10.4 PGR ESR1 ERBB2
33 multifocal osteogenic sarcoma 10.4 TP53 CD34
34 progesterone-receptor positive breast cancer 10.4 PGR ESR1 ERBB2
35 epidermolysis bullosa simplex 1b, generalized intermediate 10.4 KRT5 KRT14
36 bartholin's duct cyst 10.4 PIP CD34
37 breast leiomyoma 10.4 PGR MME
38 bartholin's gland adenoma 10.4 TP53 PGR ESR1
39 bartholin's gland benign neoplasm 10.4 TP53 PGR ESR1
40 vestibular gland benign neoplasm 10.4 TP53 PGR ESR1
41 hereditary site-specific ovarian cancer syndrome 10.4 BRCA2 BRCA1
42 urethral villous adenoma 10.4 PGR KRT7
43 epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive 10.4 KRT5 KRT14
44 ovary transitional cell carcinoma 10.4 BRCA2 BRCA1
45 spermatic cord cancer 10.4 KRT5 CD34
46 cervical serous adenocarcinoma 10.4 PGR MME
47 adenosquamous breast carcinoma 10.4 TP53 PGR KRT5
48 laryngeal adenoid cystic carcinoma 10.4 KRT7 KRT5
49 liver leiomyoma 10.4 PGR ESR1 CD34
50 intracranial meningioma 10.4 PGR ESR1 DCAF8

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:



Diseases related to Thoracic Benign Neoplasm

Symptoms & Phenotypes for Thoracic Benign Neoplasm

GenomeRNAi Phenotypes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 BRCA1 BRCA2 CD34 CDH1 DCAF8 EGFR
2 no effect GR00402-S-2 10.18 BRCA1 BRCA2 CD34 DCAF8 EGFR ERBB2
3 Decreased viability in pancreas lineage GR00235-A 9.13 KRT7 PGR TP53

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.42 BRCA1 BRCA2 CD34 CDH1 DCAF8 EGFR
2 neoplasm MP:0002006 10.36 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
3 cellular MP:0005384 10.31 BRCA1 BRCA2 CD34 CDH1 DCAF8 EGFR
4 endocrine/exocrine gland MP:0005379 10.29 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
5 normal MP:0002873 10.28 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
6 immune system MP:0005387 10.22 BRCA1 BRCA2 CD34 CDH1 DCAF8 EGFR
7 limbs/digits/tail MP:0005371 10.21 BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
8 digestive/alimentary MP:0005381 10.21 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
9 embryo MP:0005380 10.16 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
10 liver/biliary system MP:0005370 10.13 DCAF8 EGFR ESR1 MME MUC1 PRKAR1A
11 cardiovascular system MP:0005385 10.11 BRCA1 CDH1 DCAF8 EGFR ERBB2 ESR1
12 reproductive system MP:0005389 9.97 BRCA1 BRCA2 CDH1 DCAF8 EGFR ERBB2
13 respiratory system MP:0005388 9.86 BRCA1 DCAF8 EGFR ERBB2 ESR1 KRT14
14 hematopoietic system MP:0005397 9.77 BRCA1 BRCA2 CD34 DCAF8 EGFR ERBB2
15 integument MP:0010771 9.53 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2

Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Thoracic Benign Neoplasm

Genetic Tests for Thoracic Benign Neoplasm

Anatomical Context for Thoracic Benign Neoplasm

Organs/tissues related to Thoracic Benign Neoplasm:

FMA: Thoracic Cavity

Publications for Thoracic Benign Neoplasm

Variations for Thoracic Benign Neoplasm

Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TP53 PRKAR1A MUC1 ESR1 ERBB2 EGFR
2
Show member pathways
13.68 TP53 PRKAR1A PIP MUC1 ESR1 ERBB2
3
Show member pathways
12.54 TP53 ERBB2 EGFR CDH1 BRCA2
4
Show member pathways
12.34 TP53 ESR1 ERBB2 CDH1
5
Show member pathways
12.34 TP53 MUC1 ERBB2 EGFR CDH1
6
Show member pathways
12.17 PRKAR1A ESR1 ERBB2 EGFR
7 12.01 TP53 PRKAR1A EGFR CDH1
8
Show member pathways
11.93 TP53 PGR ESR1 ERBB2 EGFR BRCA2
9
Show member pathways
11.84 EGFR ERBB2 ESR1 PGR PRL
10 11.81 TP53 ESR1 EGFR CDH1 BRCA2 BRCA1
11
Show member pathways
11.73 ESR1 ERBB2 EGFR
12
Show member pathways
11.69 TP53 BRCA2 BRCA1
13 11.68 TP53 BRCA2 BRCA1
14 11.62 CD34 CDH1 MME
15 11.62 TP53 PRL KRT5 KRT14
16 11.61 TP53 ERBB2 EGFR
17 11.52 PRL PGR ESR1 BRCA1
18 11.5 TP53 ERBB2 BRCA1
19 11.36 BRCA2 KRT14 KRT5
20 11.22 ERBB2 EGFR CDH1
21 11.16 TP53 ERBB2 EGFR CDH1
22 10.66 PGR ESR1 ERBB2
23 10.58 TP53 CDH1
24 10.53 PRL PGR ESR1 ERBB2 EGFR

GO Terms for Thoracic Benign Neoplasm

Cellular components related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear ubiquitin ligase complex GO:0000152 8.92 BRCA2 BRCA1

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.67 TP53 MUC1
2 cellular response to indole-3-methanol GO:0071681 9.56 CDH1 BRCA1
3 chordate embryonic development GO:0043009 9.5 BRCA2 BRCA1
4 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 9.46 TP53 ESR1
5 cellular response to ionizing radiation GO:0071479 9.43 TP53 BRCA2 BRCA1
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.1 TP53 MUC1 BRCA2

Sources for Thoracic Benign Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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