MCID: THR011
MIFTS: 25

Thoracic Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm 12 15
Benign Neoplasm of Thorax 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060097
UMLS 73 C0346440

Summaries for Thoracic Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to vulvar syringoma and lung leiomyoma. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include the thoracic cavity, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 vulvar syringoma 11.0 ESR1 PGR
2 lung leiomyoma 10.9 ESR1 PGR
3 scirrhous adenocarcinoma 10.9 ERBB2 PGR
4 breast apocrine carcinoma 10.9 ERBB2 PGR
5 vulvar benign neoplasm 10.9 ESR1 PGR
6 vulvar leiomyoma 10.9 ESR1 PGR
7 breast mucoepidermoid carcinoma 10.9 ERBB2 PGR
8 breast metaplastic carcinoma 10.9 ERBB2 PGR
9 intracystic papillary adenoma 10.9 ERBB2 PGR
10 progesterone-receptor negative breast cancer 10.9 ERBB2 PGR
11 endometrium carcinoma in situ 10.9 PGR TP53
12 progesterone resistance 10.9 ESR1 PGR
13 cribriform carcinoma 10.9 ESR1 PGR
14 comedo carcinoma 10.9 ERBB2 ESR1
15 endometrial squamous cell carcinoma 10.8 ESR1 PGR
16 endometrial clear cell adenocarcinoma 10.8 ESR1 TP53
17 bizarre leiomyoma 10.8 MED12 PGR
18 endometrial mucinous adenocarcinoma 10.8 ESR1 PGR
19 adenoid basal cell carcinoma 10.8 ESR1 PGR
20 gender identity disorder 10.8 ESR1 PGR
21 gallbladder squamous cell carcinoma 10.8 ERBB2 TP53
22 gastric papillary adenocarcinoma 10.8 ERBB2 TP53
23 female reproductive endometrioid cancer 10.8 PGR TP53
24 olfactory groove meningioma 10.8 PGR TP53
25 uterine corpus serous adenocarcinoma 10.8 ERBB2 TP53
26 estrogen excess 10.7 ESR1 PGR
27 mammographic density 10.7 ESR1 PGR
28 non-proliferative fibrocystic change of the breast 10.7 ERBB2 TP53
29 papillary serous adenocarcinoma 10.7 PGR TP53
30 retinitis pigmentosa 47 10.7 ESR1 PGR
31 glassy cell carcinoma of the cervix 10.7 ERBB2 ESR1 PGR
32 breast medullary carcinoma 10.7 ERBB2 ESR1 PGR
33 breast scirrhous carcinoma 10.7 ERBB2 ESR1 PGR
34 progesterone-receptor positive breast cancer 10.7 ERBB2 ESR1 PGR
35 pleomorphic adenoma carcinoma 10.7 ERBB2 TP53
36 apocrine adenocarcinoma 10.7 ERBB2 ESR1 PGR
37 breast adenoid cystic carcinoma 10.7 ERBB2 ESR1 PGR
38 luminal breast carcinoma 10.7 ERBB2 ESR1 PGR
39 inflammatory breast carcinoma 10.7 ERBB2 ESR1 PGR
40 mammary paget's disease 10.7 ERBB2 ESR1 PGR
41 bilateral breast cancer 10.7 ERBB2 ESR1 PGR
42 tubular adenocarcinoma 10.7 ERBB2 ESR1 PGR
43 anterior cranial fossa meningioma 10.7 PGR TP53
44 estrogen-receptor negative breast cancer 10.6 ERBB2 ESR1 PGR
45 glioma susceptibility 1 10.6 ERBB2 TP53
46 breast malignant phyllodes tumor 10.6 PGR PTS TP53
47 vestibular gland benign neoplasm 10.6 ESR1 PGR TP53
48 bartholin's gland adenoma 10.6 ESR1 PGR TP53
49 fallopian tube endometrioid adenocarcinoma 10.6 ERBB2 MME
50 uterine benign neoplasm 10.6 ESR1 MED12 PGR

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:



Diseases related to Thoracic Benign Neoplasm

Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 PLVAP ESR1 PTS TP53 MED12 PGR
2 digestive/alimentary MP:0005381 9.97 ESR1 PTS KRT14 TP53 KRT15 ERBB2
3 homeostasis/metabolism MP:0005376 9.96 PLVAP ESR1 PTS KRT14 KRT15 TP53
4 endocrine/exocrine gland MP:0005379 9.92 PLVAP ESR1 PTS KRT14 TP53 PGR
5 integument MP:0010771 9.81 PTS KRT14 TP53 MME PGR CD34
6 limbs/digits/tail MP:0005371 9.43 PLVAP ESR1 TP53 MED12 PGR ERBB2
7 neoplasm MP:0002006 9.1 ESR1 KRT14 TP53 CD34 PGR ERBB2

Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

Genetic Tests for Thoracic Benign Neoplasm

Anatomical Context for Thoracic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

19
The Thoracic Cavity

Publications for Thoracic Benign Neoplasm

Variations for Thoracic Benign Neoplasm

Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 ESR1 MED12 TP53
2
Show member pathways
10.83 ERBB2 ESR1 PGR

GO Terms for Thoracic Benign Neoplasm

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 ESR1 MED12
2 replicative senescence GO:0090399 9.26 MME TP53
3 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
4 positive regulation of gene expression GO:0010628 9.02 CD34 ERBB2 PIP RHOXF2 TP53
5 paracrine signaling GO:0038001 8.96 CD34 PGR

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 ERBB2 ESR1 ING5 KRT14 KRT15 MED12
2 transcription factor binding GO:0008134 9.26 CD34 ESR1 MED12 TP53

Sources for Thoracic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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