MCID: THR011
MIFTS: 31

Thoracic Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm 12 15
Benign Neoplasm of Thorax 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060097
UMLS 70 C0346440

Summaries for Thoracic Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to breast benign neoplasm and chest wall lipoma. An important gene associated with Thoracic Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include thoracic cavity, breast and lung, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 511)
# Related Disease Score Top Affiliating Genes
1 breast benign neoplasm 29.5 TP53 SERPINA3 PRL PRKAR1A PIP PGR
2 axillary lipoma 11.1
3 chest wall lipoma 11.1
4 mediastinum leiomyoma 11.1
5 chronic tympanitis 10.5 PGR ESR1
6 breast adenomyoepithelioma 10.5 KRT5 KRT14
7 granulomatous endometritis 10.5 PGR ESR1
8 diffuse peritoneal leiomyomatosis 10.5 PGR MED12
9 mucoepidermoid esophageal carcinoma 10.5 TP53 KRT5
10 lung leiomyoma 10.5 PGR ESR1
11 cervical adenomyoma 10.5 PGR MME
12 cervical benign neoplasm 10.5 PGR MME
13 leiomyomatosis 10.5 PGR MED12 ESR1
14 fallopian tube endometriosis 10.5 PGR MME
15 pulmonary vein leiomyosarcoma 10.5 PGR CD34
16 vulva basal cell carcinoma 10.5 KRT5 ERBB2
17 adult type testicular granulosa cell tumor 10.5 PGR ESR1
18 gastric papillary adenocarcinoma 10.5 TP53 ERBB2
19 laryngeal mucoepidermoid carcinoma 10.5 KRT14 ERBB2
20 congenital epulis 10.5 SERPINA3 PGR
21 glassy cell carcinoma of the cervix 10.5 PGR ESR1 ERBB2
22 breast intraductal papillomatosis 10.5 PGR ESR1 ERBB2
23 nipple carcinoma 10.5 PGR ESR1 ERBB2
24 lung meningioma 10.5 PGR CD34
25 benign pleural mesothelioma 10.5 TP53 CD34
26 fallopian tube clear cell adenocarcinoma 10.4 BRCA2 BRCA1
27 multifocal osteogenic sarcoma 10.4 TP53 CD34
28 urethral villous adenoma 10.4 PGR KRT7
29 pregnancy adenoma 10.4 PGR MED12 KRT5
30 cervical serous adenocarcinoma 10.4 PGR MME
31 breast adenoid cystic carcinoma 10.4 PGR ESR1 ERBB2
32 undifferentiated embryonal sarcoma of the liver 10.4 TP53 SERPINA3
33 ureter squamous cell carcinoma 10.4 KRT7 KRT5
34 cervix erosion 10.4 MME KRT5
35 bartholin's gland adenoma 10.4 TP53 PGR ESR1
36 bartholin's gland benign neoplasm 10.4 TP53 PGR ESR1
37 vestibular gland benign neoplasm 10.4 TP53 PGR ESR1
38 apocrine adenosis of breast 10.4 TP53 PGR ERBB2
39 spermatic cord cancer 10.4 KRT5 CD34
40 progesterone-receptor positive breast cancer 10.4 PGR ESR1 ERBB2
41 mucinous adenofibroma 10.4 KRT7 ESR1
42 inverted transitional papilloma 10.4 KRT7 KRT5
43 retinitis pigmentosa 47 10.4 PGR ESR1 ERBB2
44 vulvar syringoma 10.4 PIP PGR ESR1
45 peritoneal benign neoplasm 10.4 PGR MED12 CD34
46 ovary transitional cell carcinoma 10.4 BRCA2 BRCA1
47 central nervous system fibrosarcoma 10.4 KRT7 CD34
48 pleomorphic lipoma 10.4 SERPINA3 PGR CD34
49 ureter adenocarcinoma 10.4 KRT7 KRT5
50 breast squamous cell carcinoma 10.4 TP53 KRT5 ERBB2

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:



Diseases related to Thoracic Benign Neoplasm

Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.37 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
2 homeostasis/metabolism MP:0005376 10.28 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
3 cardiovascular system MP:0005385 10.25 BRCA1 CDH1 EGFR ERBB2 ESR1 MED12
4 digestive/alimentary MP:0005381 10.22 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
5 endocrine/exocrine gland MP:0005379 10.21 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
6 immune system MP:0005387 10.21 BRCA1 BRCA2 CD34 CDH1 EGFR ESR1
7 integument MP:0010771 10.2 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
8 embryo MP:0005380 10.16 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
9 neoplasm MP:0002006 9.93 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
10 limbs/digits/tail MP:0005371 9.91 BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
11 normal MP:0002873 9.65 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
12 reproductive system MP:0005389 9.4 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1

Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

Genetic Tests for Thoracic Benign Neoplasm

Anatomical Context for Thoracic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

19
Thoracic Cavity

MalaCards organs/tissues related to Thoracic Benign Neoplasm:

40
Breast, Lung, Skin, Liver, Ovary, Prostate, Cervix

Publications for Thoracic Benign Neoplasm

Variations for Thoracic Benign Neoplasm

Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 TP53 ERBB2 EGFR CDH1 BRCA2
2 12.64 TP53 ESR1 ERBB2 EGFR CDH1 BRCA2
3
Show member pathways
12.3 TP53 ESR1 ERBB2 EGFR CDH1 BRCA2
4
Show member pathways
12.15 PRKAR1A ESR1 ERBB2 EGFR
5 12.11 TP53 ESR1 ERBB2 EGFR
6 12 TP53 PRKAR1A EGFR CDH1
7 11.9 PGR KRT14 ESR1 EGFR
8
Show member pathways
11.89 TP53 PGR ESR1 ERBB2 EGFR CDH1
9
Show member pathways
11.69 PRL PGR ESR1 ERBB2 EGFR
10
Show member pathways
11.68 TP53 BRCA2 BRCA1
11 11.62 TP53 ESR1 EGFR CDH1 BRCA2 BRCA1
12 11.61 MME CDH1 CD34
13 11.6 TP53 ERBB2 BRCA1
14 11.58 TP53 PRL KRT5 KRT14
15 11.57 ERBB2 EGFR CDH1
16 11.56 TP53 ERBB2 EGFR
17 11.51 TP53 ERBB2 BRCA1
18 11.49 TP53 ERBB2 EGFR CDH1
19 11.07 ERBB2 EGFR CDH1

GO Terms for Thoracic Benign Neoplasm

Cellular components related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10 TP53 SERPINA3 PIP PGR MED12 LCOR
2 protein-containing complex GO:0032991 9.43 TP53 PRKAR1A ESR1 EGFR BRCA2 BRCA1
3 basal plasma membrane GO:0009925 8.8 ERBB2 EGFR CD34

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 TP53 PIP ERBB2 CD34 BRCA1
2 regulation of transcription by RNA polymerase II GO:0006357 9.81 TP53 PRKAR1A PGR MED12 LCOR ESR1
3 heart development GO:0007507 9.78 TP53 PRKAR1A MED12 ERBB2
4 double-strand break repair GO:0006302 9.63 TP53 BRCA2 BRCA1
5 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.52 TP53 ESR1
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.51 TP53 ESR1
7 positive regulation of transcription, DNA-templated GO:0045893 9.5 TP53 MED12 ESR1 EGFR CDH1 BRCA2
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.49 PGR ESR1
9 paracrine signaling GO:0038001 9.43 PGR CD34
10 cellular response to estradiol stimulus GO:0071392 9.43 LCOR ESR1 EGFR
11 negative regulation of ERBB signaling pathway GO:1901185 9.4 ERBB2 EGFR
12 cellular response to indole-3-methanol GO:0071681 9.37 CDH1 BRCA1
13 chordate embryonic development GO:0043009 9.32 BRCA2 BRCA1
14 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 TP53 BRCA2 BRCA1

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TP53 SERPINA3 PRL PRKAR1A PIP PGR
2 enzyme binding GO:0019899 9.55 TP53 PGR ESR1 EGFR BRCA1
3 identical protein binding GO:0042802 9.32 TP53 PIP PGR ESR1 ERBB2 EGFR
4 nitric-oxide synthase regulator activity GO:0030235 9.26 ESR1 EGFR

Sources for Thoracic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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