Thoracic Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm ¹² ¹⁵

Benign Neoplasm of Thorax ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060097

UMLS ⁷³ C0346440

Sources

Summaries for Thoracic Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to retroperitoneal leiomyosarcoma and mammographic density. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include lung, skin and liver, and related phenotypes are digestive/alimentary and cardiovascular system

Sources

Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)

#	Related Disease	Score	Top Affiliating Genes
1	retroperitoneal leiomyosarcoma	10.3	PGR PTS
2	mammographic density	10.3	ESR1 PGR
3	retinitis pigmentosa 47	10.3	ESR1 PGR
4	retinitis pigmentosa 20	10.3	ESR1 PGR
5	gender identity disorder	10.3	ESR1 PGR
6	estrogen excess	10.3	ESR1 PGR
7	scirrhous adenocarcinoma	10.3	ERBB2 PGR
8	breast apocrine carcinoma	10.3	ERBB2 PGR
9	papillary serous adenocarcinoma	10.3	PGR TP53
10	anterior cranial fossa meningioma	10.3	PGR TP53
11	vestibular gland benign neoplasm	10.3	ESR1 PGR
12	bartholin's gland adenoma	10.3	ESR1 PGR
13	glioma susceptibility 1	10.3	ERBB2 TP53
14	vulvar syringoma	10.3	ESR1 PGR
15	esophagus adenocarcinoma	10.3	ERBB2 TP53
16	uterine corpus serous adenocarcinoma	10.3	ERBB2 TP53
17	lung leiomyoma	10.3	ESR1 PGR
18	vulvar benign neoplasm	10.3	ESR1 PGR
19	vulvar leiomyoma	10.3	ESR1 PGR
20	intracystic papillary adenoma	10.3	ERBB2 PGR
21	progesterone-receptor negative breast cancer	10.3	ERBB2 PGR
22	endometrium carcinoma in situ	10.3	PGR TP53
23	bartholin's gland benign neoplasm	10.2	ESR1 PGR
24	comedo carcinoma	10.2	ERBB2 ESR1
25	bizarre leiomyoma	10.2	MED12 PGR
26	gastric papillary adenocarcinoma	10.2	ERBB2 TP53
27	endometrial stromal nodule	10.2	MME PGR
28	prostate squamous cell carcinoma	10.2	KRT5 TP53
29	perivascular epithelioid cell tumor	10.2	MME PGR
30	cystic nephroma	10.2	MME PGR
31	epidermolysis bullosa simplex, generalized	10.2	KRT14 KRT5
32	epidermolysis bullosa simplex with mottled pigmentation	10.2	KRT14 KRT5
33	glassy cell carcinoma of the cervix	10.2	ERBB2 ESR1 PGR
34	breast medullary carcinoma	10.2	ERBB2 ESR1 PGR
35	breast scirrhous carcinoma	10.2	ERBB2 ESR1 PGR
36	odontoma	10.2	KRT14 KRT5
37	progesterone-receptor positive breast cancer	10.2	ERBB2 ESR1 PGR
38	leiomyomatosis	10.2	ESR1 MED12 PGR
39	breast adenoid cystic carcinoma	10.2	ERBB2 ESR1 PGR
40	myoma	10.2	ESR1 MED12 PGR
41	progesterone resistance	10.2	ESR1 PGR
42	breast cystic hypersecretory carcinoma	10.2	ERBB2 KRT5
43	inflammatory breast carcinoma	10.2	ERBB2 ESR1 PGR
44	luminal breast carcinoma	10.2	ERBB2 ESR1 PGR
45	mammary paget's disease	10.2	ERBB2 ESR1 PGR
46	tubular adenocarcinoma	10.2	ERBB2 ESR1 PGR
47	pleomorphic adenoma carcinoma	10.2	ERBB2 TP53
48	endometrial squamous cell carcinoma	10.2	ESR1 PGR
49	estrogen-receptor negative breast cancer	10.2	ERBB2 ESR1 PGR
50	ovarian disease	10.2	ESR1 PGR TP53

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:

Sources

Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	10.02	ERBB2 ESR1 KRT14 KRT15 KRT5 PIP
2	cardiovascular system	MP:0005385	10.01	ERBB2 ESR1 MED12 PGR PIP PLVAP
3	homeostasis/metabolism	MP:0005376	9.96	CD34 ERBB2 ESR1 KRT14 KRT15 MME
4	endocrine/exocrine gland	MP:0005379	9.92	ERBB2 ESR1 KRT14 PGR PIP PLVAP
5	integument	MP:0010771	9.85	CD34 ERBB2 ESR1 KRT14 KRT5 MME
6	limbs/digits/tail	MP:0005371	9.5	ERBB2 ESR1 KRT5 MED12 PGR PLVAP
7	neoplasm	MP:0002006	9.1	CD34 ERBB2 ESR1 KRT14 PGR TP53

Sources

Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

Sources

Genetic Tests for Thoracic Benign Neoplasm

Sources

Anatomical Context for Thoracic Benign Neoplasm

MalaCards organs/tissues related to Thoracic Benign Neoplasm:

⁴¹

Lung, Skin, Liver, Bone, Ovary, Prostate, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

¹⁹

The Thoracic Cavity

Sources

Publications for Thoracic Benign Neoplasm

Sources

Genes for Thoracic Benign Neoplasm

Genes related to Thoracic Benign Neoplasm (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	16.34	DISEASES inferred ¹⁵
2	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	16.1	DISEASES inferred ¹⁵
3	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	15.8	DISEASES inferred ¹⁵
4	ESR1	Estrogen Receptor 1	Protein Coding	15.79	DISEASES inferred ¹⁵
5	MED12	Mediator Complex Subunit 12	Protein Coding	15.67	DISEASES inferred ¹⁵
6	PLVAP	Plasmalemma Vesicle Associated Protein	Protein Coding	15.63	DISEASES inferred ¹⁵
7	RHOXF2	Rhox Homeobox Family Member 2	Protein Coding	14.97	DISEASES inferred ¹⁵
8	TP53	Tumor Protein P53	Protein Coding	14.97	DISEASES inferred ¹⁵
9	KRT14	Keratin 14	Protein Coding	14.89	DISEASES inferred ¹⁵
10	KRT5	Keratin 5	Protein Coding	14.55	DISEASES inferred ¹⁵
11	KRT15	Keratin 15	Protein Coding	14.52	DISEASES inferred ¹⁵
12	MME	Membrane Metalloendopeptidase	Protein Coding	14.52	DISEASES inferred ¹⁵
13	PIP	Prolactin Induced Protein	Protein Coding	5.44	DISEASES inferred ¹⁵
14	CD34	CD34 Molecule	Protein Coding	5.36	DISEASES inferred ¹⁵
15	ING5	Inhibitor Of Growth Family Member 5	Protein Coding	4.89	DISEASES inferred ¹⁵

Sources

Variations for Thoracic Benign Neoplasm

Sources

Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

Sources

Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Thyroid hormone signaling pathway ³⁷	11.4	ESR1 MED12 TP53
2	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	11.17	ERBB2 ESR1 PGR
3	Glucocorticoid receptor regulatory network ¹	10.71	KRT14 KRT5 TP53

Sources

GO Terms for Thoracic Benign Neoplasm

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cornification	GO:0070268	9.58	KRT14 KRT15 KRT5
2	epidermis development	GO:0008544	9.54	KRT14 KRT15 KRT5
3	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.43	ESR1 MED12
4	replicative senescence	GO:0090399	9.32	MME TP53
5	hemidesmosome assembly	GO:0031581	9.26	KRT14 KRT5
6	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.16	ESR1 TP53
7	positive regulation of gene expression	GO:0010628	9.02	CD34 ERBB2 PIP RHOXF2 TP53
8	paracrine signaling	GO:0038001	8.96	CD34 PGR

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	9.62	ESR1 ING5 MED12 TP53
2	transcription factor binding	GO:0008134	9.56	CD34 ESR1 MED12 TP53
3	protein binding	GO:0005515	9.47	ERBB2 ESR1 ING5 KRT14 KRT15 KRT5
4	identical protein binding	GO:0042802	9.43	ERBB2 ESR1 PGR PTS RHOXF2 TP53
5	structural constituent of cytoskeleton	GO:0005200	9.33	KRT14 KRT15 KRT5

Sources

Sources for Thoracic Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia