MCID: THR011
MIFTS: 30

Thoracic Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm 12 15
Benign Neoplasm of Thorax 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060097
UMLS 73 C0346440

Summaries for Thoracic Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to retroperitoneal leiomyosarcoma and mammographic density. An important gene associated with Thoracic Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include lung, skin and liver, and related phenotypes are digestive/alimentary and cardiovascular system

Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 retroperitoneal leiomyosarcoma 10.3 PGR PTS
2 mammographic density 10.3 ESR1 PGR
3 retinitis pigmentosa 47 10.3 ESR1 PGR
4 retinitis pigmentosa 20 10.3 ESR1 PGR
5 gender identity disorder 10.3 ESR1 PGR
6 estrogen excess 10.3 ESR1 PGR
7 scirrhous adenocarcinoma 10.3 ERBB2 PGR
8 breast apocrine carcinoma 10.3 ERBB2 PGR
9 papillary serous adenocarcinoma 10.3 PGR TP53
10 anterior cranial fossa meningioma 10.3 PGR TP53
11 vestibular gland benign neoplasm 10.3 ESR1 PGR
12 bartholin's gland adenoma 10.3 ESR1 PGR
13 glioma susceptibility 1 10.3 ERBB2 TP53
14 vulvar syringoma 10.3 ESR1 PGR
15 esophagus adenocarcinoma 10.3 ERBB2 TP53
16 uterine corpus serous adenocarcinoma 10.3 ERBB2 TP53
17 lung leiomyoma 10.3 ESR1 PGR
18 vulvar benign neoplasm 10.3 ESR1 PGR
19 vulvar leiomyoma 10.3 ESR1 PGR
20 intracystic papillary adenoma 10.3 ERBB2 PGR
21 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
22 endometrium carcinoma in situ 10.3 PGR TP53
23 bartholin's gland benign neoplasm 10.2 ESR1 PGR
24 comedo carcinoma 10.2 ERBB2 ESR1
25 bizarre leiomyoma 10.2 MED12 PGR
26 gastric papillary adenocarcinoma 10.2 ERBB2 TP53
27 endometrial stromal nodule 10.2 MME PGR
28 prostate squamous cell carcinoma 10.2 KRT5 TP53
29 perivascular epithelioid cell tumor 10.2 MME PGR
30 cystic nephroma 10.2 MME PGR
31 epidermolysis bullosa simplex, generalized 10.2 KRT14 KRT5
32 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT14 KRT5
33 glassy cell carcinoma of the cervix 10.2 ERBB2 ESR1 PGR
34 breast medullary carcinoma 10.2 ERBB2 ESR1 PGR
35 breast scirrhous carcinoma 10.2 ERBB2 ESR1 PGR
36 odontoma 10.2 KRT14 KRT5
37 progesterone-receptor positive breast cancer 10.2 ERBB2 ESR1 PGR
38 leiomyomatosis 10.2 ESR1 MED12 PGR
39 breast adenoid cystic carcinoma 10.2 ERBB2 ESR1 PGR
40 myoma 10.2 ESR1 MED12 PGR
41 progesterone resistance 10.2 ESR1 PGR
42 breast cystic hypersecretory carcinoma 10.2 ERBB2 KRT5
43 inflammatory breast carcinoma 10.2 ERBB2 ESR1 PGR
44 luminal breast carcinoma 10.2 ERBB2 ESR1 PGR
45 mammary paget's disease 10.2 ERBB2 ESR1 PGR
46 tubular adenocarcinoma 10.2 ERBB2 ESR1 PGR
47 pleomorphic adenoma carcinoma 10.2 ERBB2 TP53
48 endometrial squamous cell carcinoma 10.2 ESR1 PGR
49 estrogen-receptor negative breast cancer 10.2 ERBB2 ESR1 PGR
50 ovarian disease 10.2 ESR1 PGR TP53

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:



Diseases related to Thoracic Benign Neoplasm

Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.02 ERBB2 ESR1 KRT14 KRT15 KRT5 PIP
2 cardiovascular system MP:0005385 10.01 ERBB2 ESR1 MED12 PGR PIP PLVAP
3 homeostasis/metabolism MP:0005376 9.96 CD34 ERBB2 ESR1 KRT14 KRT15 MME
4 endocrine/exocrine gland MP:0005379 9.92 ERBB2 ESR1 KRT14 PGR PIP PLVAP
5 integument MP:0010771 9.85 CD34 ERBB2 ESR1 KRT14 KRT5 MME
6 limbs/digits/tail MP:0005371 9.5 ERBB2 ESR1 KRT5 MED12 PGR PLVAP
7 neoplasm MP:0002006 9.1 CD34 ERBB2 ESR1 KRT14 PGR TP53

Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

Genetic Tests for Thoracic Benign Neoplasm

Anatomical Context for Thoracic Benign Neoplasm

MalaCards organs/tissues related to Thoracic Benign Neoplasm:

41
Lung, Skin, Liver, Bone, Ovary, Prostate, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

19
The Thoracic Cavity

Publications for Thoracic Benign Neoplasm

Variations for Thoracic Benign Neoplasm

Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 ESR1 MED12 TP53
2
Show member pathways
11.17 ERBB2 ESR1 PGR
3 10.71 KRT14 KRT5 TP53

GO Terms for Thoracic Benign Neoplasm

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.58 KRT14 KRT15 KRT5
2 epidermis development GO:0008544 9.54 KRT14 KRT15 KRT5
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 ESR1 MED12
4 replicative senescence GO:0090399 9.32 MME TP53
5 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
7 positive regulation of gene expression GO:0010628 9.02 CD34 ERBB2 PIP RHOXF2 TP53
8 paracrine signaling GO:0038001 8.96 CD34 PGR

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.62 ESR1 ING5 MED12 TP53
2 transcription factor binding GO:0008134 9.56 CD34 ESR1 MED12 TP53
3 protein binding GO:0005515 9.47 ERBB2 ESR1 ING5 KRT14 KRT15 KRT5
4 identical protein binding GO:0042802 9.43 ERBB2 ESR1 PGR PTS RHOXF2 TP53
5 structural constituent of cytoskeleton GO:0005200 9.33 KRT14 KRT15 KRT5

Sources for Thoracic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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