Thoracic Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: THR011 MIFTS: 31	Thoracic Benign Neoplasm Categories: Cancer diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Thoracic Benign Neoplasm

MalaCards integrated aliases for Thoracic Benign Neoplasm:

Name: Thoracic Benign Neoplasm ¹² ¹⁵

Benign Neoplasm of Thorax ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060097

UMLS ⁷⁰ C0346440

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Summaries for Thoracic Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplam that is located in the thoracic cavity.

MalaCards based summary : Thoracic Benign Neoplasm, also known as benign neoplasm of thorax, is related to breast benign neoplasm and chest wall lipoma. An important gene associated with Thoracic Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include thoracic cavity, breast and lung, and related phenotypes are cellular and homeostasis/metabolism

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Related Diseases for Thoracic Benign Neoplasm

Diseases related to Thoracic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 511)

#	Related Disease	Score	Top Affiliating Genes
1	breast benign neoplasm	29.5	TP53 SERPINA3 PRL PRKAR1A PIP PGR
2	axillary lipoma	11.1
3	chest wall lipoma	11.1
4	mediastinum leiomyoma	11.1
5	chronic tympanitis	10.5	PGR ESR1
6	breast adenomyoepithelioma	10.5	KRT5 KRT14
7	granulomatous endometritis	10.5	PGR ESR1
8	diffuse peritoneal leiomyomatosis	10.5	PGR MED12
9	mucoepidermoid esophageal carcinoma	10.5	TP53 KRT5
10	lung leiomyoma	10.5	PGR ESR1
11	cervical adenomyoma	10.5	PGR MME
12	cervical benign neoplasm	10.5	PGR MME
13	leiomyomatosis	10.5	PGR MED12 ESR1
14	fallopian tube endometriosis	10.5	PGR MME
15	pulmonary vein leiomyosarcoma	10.5	PGR CD34
16	vulva basal cell carcinoma	10.5	KRT5 ERBB2
17	adult type testicular granulosa cell tumor	10.5	PGR ESR1
18	gastric papillary adenocarcinoma	10.5	TP53 ERBB2
19	laryngeal mucoepidermoid carcinoma	10.5	KRT14 ERBB2
20	congenital epulis	10.5	SERPINA3 PGR
21	glassy cell carcinoma of the cervix	10.5	PGR ESR1 ERBB2
22	breast intraductal papillomatosis	10.5	PGR ESR1 ERBB2
23	nipple carcinoma	10.5	PGR ESR1 ERBB2
24	lung meningioma	10.5	PGR CD34
25	benign pleural mesothelioma	10.5	TP53 CD34
26	fallopian tube clear cell adenocarcinoma	10.4	BRCA2 BRCA1
27	multifocal osteogenic sarcoma	10.4	TP53 CD34
28	urethral villous adenoma	10.4	PGR KRT7
29	pregnancy adenoma	10.4	PGR MED12 KRT5
30	cervical serous adenocarcinoma	10.4	PGR MME
31	breast adenoid cystic carcinoma	10.4	PGR ESR1 ERBB2
32	undifferentiated embryonal sarcoma of the liver	10.4	TP53 SERPINA3
33	ureter squamous cell carcinoma	10.4	KRT7 KRT5
34	cervix erosion	10.4	MME KRT5
35	bartholin's gland adenoma	10.4	TP53 PGR ESR1
36	bartholin's gland benign neoplasm	10.4	TP53 PGR ESR1
37	vestibular gland benign neoplasm	10.4	TP53 PGR ESR1
38	apocrine adenosis of breast	10.4	TP53 PGR ERBB2
39	spermatic cord cancer	10.4	KRT5 CD34
40	progesterone-receptor positive breast cancer	10.4	PGR ESR1 ERBB2
41	mucinous adenofibroma	10.4	KRT7 ESR1
42	inverted transitional papilloma	10.4	KRT7 KRT5
43	retinitis pigmentosa 47	10.4	PGR ESR1 ERBB2
44	vulvar syringoma	10.4	PIP PGR ESR1
45	peritoneal benign neoplasm	10.4	PGR MED12 CD34
46	ovary transitional cell carcinoma	10.4	BRCA2 BRCA1
47	central nervous system fibrosarcoma	10.4	KRT7 CD34
48	pleomorphic lipoma	10.4	SERPINA3 PGR CD34
49	ureter adenocarcinoma	10.4	KRT7 KRT5
50	breast squamous cell carcinoma	10.4	TP53 KRT5 ERBB2

Graphical network of the top 20 diseases related to Thoracic Benign Neoplasm:

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Symptoms & Phenotypes for Thoracic Benign Neoplasm

MGI Mouse Phenotypes related to Thoracic Benign Neoplasm:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.37	BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
2	homeostasis/metabolism	MP:0005376	10.28	BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
3	cardiovascular system	MP:0005385	10.25	BRCA1 CDH1 EGFR ERBB2 ESR1 MED12
4	digestive/alimentary	MP:0005381	10.22	BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
5	endocrine/exocrine gland	MP:0005379	10.21	BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
6	immune system	MP:0005387	10.21	BRCA1 BRCA2 CD34 CDH1 EGFR ESR1
7	integument	MP:0010771	10.2	BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
8	embryo	MP:0005380	10.16	BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
9	neoplasm	MP:0002006	9.93	BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
10	limbs/digits/tail	MP:0005371	9.91	BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
11	normal	MP:0002873	9.65	BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
12	reproductive system	MP:0005389	9.4	BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1

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Drugs & Therapeutics for Thoracic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Thoracic Benign Neoplasm

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Genetic Tests for Thoracic Benign Neoplasm

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Anatomical Context for Thoracic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Thoracic Benign Neoplasm:

¹⁹

Thoracic Cavity

MalaCards organs/tissues related to Thoracic Benign Neoplasm:

⁴⁰

Breast, Lung, Skin, Liver, Ovary, Prostate, Cervix

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Publications for Thoracic Benign Neoplasm

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Genes for Thoracic Benign Neoplasm

Genes related to Thoracic Benign Neoplasm (0 elite genes):

(show all 29)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA3	Serpin Family A Member 3	Protein Coding	8.14	DISEASES inferred ¹⁵ ¹⁵
2	MED12	Mediator Complex Subunit 12	Protein Coding	7.69	DISEASES inferred ¹⁵
3	PGR	Progesterone Receptor	Protein Coding	7.68	DISEASES inferred ¹⁵
4	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	7.66	DISEASES inferred ¹⁵
5	ESR1	Estrogen Receptor 1	Protein Coding	7.46	DISEASES inferred ¹⁵
6	CT45A10	Cancer/Testis Antigen Family 45 Member A10	Protein Coding	7.41	DISEASES inferred ¹⁵ ¹⁵
7	LCOR	Ligand Dependent Nuclear Receptor Corepressor	Protein Coding	7.09	DISEASES inferred ¹⁵ ¹⁵
8	KRT5	Keratin 5	Protein Coding	6.8	DISEASES inferred ¹⁵
9	TP53	Tumor Protein P53	Protein Coding	6.63	DISEASES inferred ¹⁵
10	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	6.46	DISEASES inferred ¹⁵
11	PIP	Prolactin Induced Protein	Protein Coding	6.46	DISEASES inferred ¹⁵
12	CD34	CD34 Molecule	Protein Coding	6.34	DISEASES inferred ¹⁵
13	KRT14	Keratin 14	Protein Coding	6.22	DISEASES inferred ¹⁵
14	MME	Membrane Metalloendopeptidase	Protein Coding	6.07	DISEASES inferred ¹⁵
15	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	6.02	DISEASES inferred ¹⁵
16	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.99	DISEASES inferred ¹⁵
17	KRT7	Keratin 7	Protein Coding	5.95	DISEASES inferred ¹⁵
18	PRL	Prolactin	Protein Coding	5.95	DISEASES inferred ¹⁵
19	CDH1	Cadherin 1	Protein Coding	5.92	DISEASES inferred ¹⁵
20	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	5.86	DISEASES inferred ¹⁵
21	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	5.79	DISEASES inferred ¹⁵
22	KRT8	Keratin 8	Protein Coding	5.73	DISEASES inferred ¹⁵
23	PRLR	Prolactin Receptor	Protein Coding	5.7	DISEASES inferred ¹⁵
24	ESR2	Estrogen Receptor 2	Protein Coding	5.66	DISEASES inferred ¹⁵
25	CDK8	Cyclin Dependent Kinase 8	Protein Coding	5.65	DISEASES inferred ¹⁵
26	RASSF1	Ras Association Domain Family Member 1	Protein Coding	5.6	DISEASES inferred ¹⁵
27	EGF	Epidermal Growth Factor	Protein Coding	5.57	DISEASES inferred ¹⁵
28	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.56	DISEASES inferred ¹⁵
29	CCNC	Cyclin C	Protein Coding	5.56	DISEASES inferred ¹⁵

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Variations for Thoracic Benign Neoplasm

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Expression for Thoracic Benign Neoplasm

Search GEO for disease gene expression data for Thoracic Benign Neoplasm.

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Pathways for Thoracic Benign Neoplasm

Pathways related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.66	TP53 ERBB2 EGFR CDH1 BRCA2
2	Pathways in cancer ³⁶	12.64	TP53 ESR1 ERBB2 EGFR CDH1 BRCA2
3	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.3	TP53 ESR1 ERBB2 EGFR CDH1 BRCA2
4	Development Ligand-independent activation of ESR1 and ESR2 ²³ Show member pathways Transcription CREB pathway ²³ Transcription PPAR Pathway ²³	12.15	PRKAR1A ESR1 ERBB2 EGFR
5	Proteoglycans in cancer ³⁶	12.11	TP53 ESR1 ERBB2 EGFR
6	Colorectal Cancer Metastasis ⁶³	12	TP53 PRKAR1A EGFR CDH1
7	Estrogen signaling pathway (KEGG) ³⁶	11.9	PGR KRT14 ESR1 EGFR
8	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	11.89	TP53 PGR ESR1 ERBB2 EGFR CDH1
9	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	11.69	PRL PGR ESR1 ERBB2 EGFR
10	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	11.68	TP53 BRCA2 BRCA1
11	Integrated Breast Cancer Pathway ¹	11.62	TP53 ESR1 EGFR CDH1 BRCA2 BRCA1
12	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.61	MME CDH1 CD34
13	Platinum drug resistance ³⁶	11.6	TP53 ERBB2 BRCA1
14	Glucocorticoid receptor regulatory network ¹	11.58	TP53 PRL KRT5 KRT14
15	Adherens junction ³⁶	11.57	ERBB2 EGFR CDH1
16	Central carbon metabolism in cancer ³⁶	11.56	TP53 ERBB2 EGFR
17	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.51	TP53 ERBB2 BRCA1
18	Bladder cancer ³⁶ ¹	11.49	TP53 ERBB2 EGFR CDH1
19	a6b1 and a6b4 Integrin signaling ¹	11.07	ERBB2 EGFR CDH1

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GO Terms for Thoracic Benign Neoplasm

Cellular components related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	10	TP53 SERPINA3 PIP PGR MED12 LCOR
2	protein-containing complex	GO:0032991	9.43	TP53 PRKAR1A ESR1 EGFR BRCA2 BRCA1
3	basal plasma membrane	GO:0009925	8.8	ERBB2 EGFR CD34

Biological processes related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.93	TP53 PIP ERBB2 CD34 BRCA1
2	regulation of transcription by RNA polymerase II	GO:0006357	9.81	TP53 PRKAR1A PGR MED12 LCOR ESR1
3	heart development	GO:0007507	9.78	TP53 PRKAR1A MED12 ERBB2
4	double-strand break repair	GO:0006302	9.63	TP53 BRCA2 BRCA1
5	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903799	9.52	TP53 ESR1
6	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.51	TP53 ESR1
7	positive regulation of transcription, DNA-templated	GO:0045893	9.5	TP53 MED12 ESR1 EGFR CDH1 BRCA2
8	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.49	PGR ESR1
9	paracrine signaling	GO:0038001	9.43	PGR CD34
10	cellular response to estradiol stimulus	GO:0071392	9.43	LCOR ESR1 EGFR
11	negative regulation of ERBB signaling pathway	GO:1901185	9.4	ERBB2 EGFR
12	cellular response to indole-3-methanol	GO:0071681	9.37	CDH1 BRCA1
13	chordate embryonic development	GO:0043009	9.32	BRCA2 BRCA1
14	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	8.8	TP53 BRCA2 BRCA1

Molecular functions related to Thoracic Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.96	TP53 SERPINA3 PRL PRKAR1A PIP PGR
2	enzyme binding	GO:0019899	9.55	TP53 PGR ESR1 EGFR BRCA1
3	identical protein binding	GO:0042802	9.32	TP53 PIP PGR ESR1 ERBB2 EGFR
4	nitric-oxide synthase regulator activity	GO:0030235	9.26	ESR1 EGFR

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Sources for Thoracic Benign Neoplasm

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⁵⁴ Novoseek

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⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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