MCID: THR013
MIFTS: 56

Thoracic Outlet Syndrome

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Thoracic Outlet Syndrome

MalaCards integrated aliases for Thoracic Outlet Syndrome:

Name: Thoracic Outlet Syndrome 12 77 55 60 44 45 15 17 74
Tos 54 60
Thoracic Outlet Compression Syndrome 60
Tos - Thoracic Outlet Syndrome 12
Thoracic Outlet Syndromes 54
Abnormality of Toe 30

Classifications:



External Ids:

Disease Ontology 12 DOID:3103
MeSH 45 D013901
NCIt 51 C85188
SNOMED-CT 69 2040007
ICD10 34 G54.0
MESH via Orphanet 46 D013901
ICD10 via Orphanet 35 G54.0
UMLS via Orphanet 75 C0039984
Orphanet 60 ORPHA97330
UMLS 74 C0039984

Summaries for Thoracic Outlet Syndrome

NINDS : 55 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.  Most doctors agree that TOS is caused by compression of the brachial plexus or subclavian vessels as they pass through narrow passageways leading from the base of the neck to the armpit and arm, but there is considerable disagreement about its diagnosis and treatment. Making the diagnosis of TOS even more difficult is that a number of disorders feature symptoms similar to those of TOS, including rotator cuff injuries, cervical disc disorders, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord.  The disorder can sometimes be diagnosed in a physical exam by tenderness in the supraclavicular area, weakness and/or a "pins and needles" feeling when elevating the hands, weakness in the fifth ("little") finger, and paleness in the palm of one or both hands when the individual raises them above the shoulders, with the fingers pointing to the ceiling.  Symptoms of TOS vary depending on the type. Neurogenic TOS has a characteristic sign, called the Gilliatt-Sumner hand, in which there is severe wasting in the fleshy base of the thumb.  Other symptoms include paresthesias (pins and needles sensation or numbness) in the fingers and hand, change in hand color, hand coldness, or dull aching pain in the neck, shoulder, and armpit.  Venous TOS features pallor, a weak or absent pulse in the affected arm, which also may be cool to the touch and appear paler than the unaffected arm.  Symptoms may include numbness, tingling, aching, swelling of the extremity and fingers, and weakness of the neck or arm.  Arterial TOS most prominently features change in color and cold sensitivity in the hands and fingers, swelling, heaviness, paresthesias and poor blood circulation in the arms, hands, and fingers. There are many causes of TOS, including physical trauma, anatomical defects, tumors that press on nerves, poor posture that causes nerve compression, pregnancy, and repetitive arm and shoulder movements and activity, such as from playing certain sports.   TOS is more common in women.  The onset of symptoms usually occurs between 20 and 50 years of age.  Doctors usually recommend nerve conduction studies, electromyography, or imaging studies to confirm or rule out a diagnosis of TOS.

MalaCards based summary : Thoracic Outlet Syndrome, also known as tos, is related to neurogenic thoracic outlet syndrome and venous thoracic outlet syndrome, and has symptoms including seizures, tremor and back pain. An important gene associated with Thoracic Outlet Syndrome is HHAT (Hedgehog Acyltransferase). The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and kidney, and related phenotypes are paresthesia and muscle weakness

Disease Ontology : 12 A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles.

NIH Rare Diseases : 54 Thoracic outlet syndromes (TOSs) are a group of disorders with one common feature: the compression of 1 or more of the nerves and/or blood vessels just above the first rib and behind the collarbone. There are 4 recognized subtypes of TOS, each with a distinct cause and pattern of symptoms. A fifth subtype is controversial. While thoracic outlet syndromes as a group are not rare, individual subtypes of TOS are considered rare. The subtypes include:Arterial TOS (A-TOS) - due to compression of the subclavian artery, most commonly caused by a cervical rib. Symptoms may include blood clots, arm pain with exertion, or acute arterial thrombosis (sudden blood flow obstruction in an artery). Venous TOS (V-TOS) - due to compression of the subclavian vein, often associated with repetitive arm activities. It may cause pain, swelling, and deep vein thrombosis. Traumatic neurovascular TOS - occurs after trauma to the collarbone and may affect both nerves and vessels. Symptoms may include pain, swelling, bruising, weakness, and loss of sensation in the arm and hand. True neurogenic TOS (TN-TOS) - caused by compression of the brachial plexus. Symptoms include numbness, abnormal sensations, and weakness of the arms and shoulders, as well as pain in the neck, shoulder or hand. Disputed TOS - the vast majority of neurogenic cases. It is controversial whether it is a true form of TOS because it lacks a consistent physical abnormality, a recognized cause, consistent symptoms, a reliable method of testing, and a standard treatment. Pain and tingling or numbness in the neck, arm and hand are common complaints. Treatment for TOS depends on the type and whether symptoms are present. Treatment may involve physical therapy, oral or injected medication (e.g. pain medicine or steroids), thoracic outlet decompression surgery, and/or thrombolytic therapy.

MedlinePlus : 44 Thoracic outlet syndrome (TOS) causes pain in the shoulder, arm, and neck. It happens when the nerves or blood vessels just below your neck are compressed, or squeezed. The compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. You may feel burning, tingling, and numbness along your arm, hand, and fingers. If a nerve is compressed, you may also feel weakness in your hand. If a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. Your arm might swell and tire easily. TOS is more common in women. It usually starts between 20 and 50 years of age. Doctors do nerve and imaging studies to diagnose it. There are many causes of TOS, including Injury Anatomical defects Tumors that press on nerves Poor posture that causes nerve compression Pregnancy Repetitive arm and shoulder movements and activity, such as from playing certain sports Treatment depends on what caused your TOS. Medicines, physical therapy, and relaxation might help. Surgery may also be an option. Most people recover. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Thoracic outlet syndrome (TOS) is a condition in which there is compression of the nerves, arteries, or... more...

Related Diseases for Thoracic Outlet Syndrome

Diseases related to Thoracic Outlet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 11971)
# Related Disease Score Top Affiliating Genes
1 neurogenic thoracic outlet syndrome 12.5
2 venous thoracic outlet syndrome 12.5
3 arterial thoracic outlet syndrome 12.5
4 twin-to-twin transfusion syndrome 12.2
5 hemolytic anemia, nonspherocytic, due to hexokinase deficiency 12.1
6 severe combined immunodeficiency with sensitivity to ionizing radiation 12.1
7 neuropathy, hereditary, with liability to pressure palsies 12.1
8 thrombophilia due to activated protein c resistance 12.1
9 thrombophilia due to thrombomodulin defect 12.1
10 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 12.1
11 insensitivity to pain, congenital, with anhidrosis 12.1
12 anemia, nonspherocytic hemolytic, due to g6pd deficiency 12.1
13 adenylate kinase deficiency, hemolytic anemia due to 12.1
14 disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency 12.1
15 glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to 12.1
16 thrombophilia due to protein c deficiency, autosomal recessive 12.1
17 severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency 12.1
18 thrombophilia due to thrombin defect 12.1
19 adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency 12.1
20 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 12.1
21 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 12.1
22 uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to 12.0
23 methylmalonic aciduria due to methylmalonyl-coa mutase deficiency 12.0
24 encephalopathy due to defective mitochondrial and peroxisomal fission 1 12.0
25 indifference to pain, congenital, autosomal recessive 12.0
26 adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency 12.0
27 megaloblastic anemia due to dihydrofolate reductase deficiency 12.0
28 homocystinuria due to cystathionine beta-synthase deficiency 12.0
29 cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 12.0
30 gamma-glutamylcysteine synthetase deficiency, hemolytic anemia due to 12.0
31 homocystinuria due to cbs deficiency 12.0
32 carbonic anhydrase va deficiency, hyperammonemia due to 12.0
33 myopathy due to myoadenylate deaminase deficiency 12.0
34 hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 12.0
35 lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency 12.0
36 pseudohyperkalemia, familial, 2, due to red cell leak 12.0
37 gaucher disease, atypical, due to saposin c deficiency 12.0
38 thrombocytopenia due to platelet alloimmunization 12.0
39 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 12.0
40 methemoglobinemia due to deficiency of methemoglobin reductase 12.0
41 thrombophilia, x-linked, due to factor ix defect 12.0
42 encephalopathy due to defective mitochondrial and peroxisomal fission 2 12.0
43 adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency 12.0
44 cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1 12.0
45 thrombophilia due to protein c deficiency, autosomal dominant 12.0
46 ornithine transcarbamylase deficiency, hyperammonemia due to 12.0
47 muscular dystrophy, congenital, due to integrin alpha-7 deficiency 12.0
48 severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation 12.0
49 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 12.0
50 hyperphenylalaninemia due to dehydratase deficiency 12.0

Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:



Diseases related to Thoracic Outlet Syndrome

Symptoms & Phenotypes for Thoracic Outlet Syndrome

Human phenotypes related to Thoracic Outlet Syndrome:

60 33 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 paresthesia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003401
2 muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0001324
3 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
4 edema 60 33 frequent (33%) Frequent (79-30%) HP:0000969
5 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
6 abnormality of the ribs 60 33 frequent (33%) Frequent (79-30%) HP:0000772
7 emg abnormality 60 33 occasional (7.5%) Occasional (29-5%) HP:0003457
8 venous thrombosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004936
9 varicose veins 60 33 occasional (7.5%) Occasional (29-5%) HP:0002619
10 muscle spasm 33 occasional (7.5%) HP:0003394
11 sensory neuropathy 60 Occasional (29-5%)
12 muscle cramps 60 Occasional (29-5%)

UMLS symptoms related to Thoracic Outlet Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

GenomeRNAi Phenotypes related to Thoracic Outlet Syndrome according to GeneCards Suite gene sharing:

27 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.47 HHAT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.47 HHAT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 HHAT
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.47 SIRPA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.47 SIRPA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.47 SIRPA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.47 HHAT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.47 SIRPA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.47 HHAT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.47 HHAT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.47 HHAT SIRPA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 SIRPA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.47 HHAT
14 Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor) GR00198-A-1 9.33 GSTO1 RBM8A SIRPA
15 Increased number of mitotic cells GR00098-A-3 8.96 RBM8A SIRPA

Drugs & Therapeutics for Thoracic Outlet Syndrome

Drugs for Thoracic Outlet Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
2
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Not Applicable
6 Central Nervous System Depressants Phase 4,Not Applicable
7 Excitatory Amino Acid Antagonists Phase 4
8 Adrenergic Agonists Phase 4
9 Adrenergic alpha-2 Receptor Agonists Phase 4
10 Anesthetics Phase 4,Not Applicable
11 Anesthetics, Dissociative Phase 4
12 Anesthetics, Intravenous Phase 4,Not Applicable
13 Adrenergic alpha-Agonists Phase 4
14 Adrenergic Agents Phase 4
15 Analgesics Phase 4,Phase 3
16 Anesthetics, General Phase 4,Not Applicable
17 Analgesics, Non-Narcotic Phase 4,Phase 3
18 Excitatory Amino Acids Phase 4
19 Hypnotics and Sedatives Phase 4,Not Applicable
20 Pharmaceutical Solutions Phase 4,Phase 3,Not Applicable
21 Ecallantide Approved, Investigational Phase 3 460738-38-9
22 Antirheumatic Agents Phase 3
23 Anti-Inflammatory Agents, Non-Steroidal Phase 3
24 Anti-Inflammatory Agents Phase 3
25 Kallikreins Phase 3
26 Plasma Kallikrein Phase 3
27
Acetylcholine Approved, Investigational Phase 2,Phase 1 51-84-3 187
28
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
29
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
30 Neuromuscular Agents Phase 2,Phase 1
31 abobotulinumtoxinA Phase 2,Phase 1
32 Botulinum Toxins Phase 2,Phase 1
33 Acetylcholine Release Inhibitors Phase 2,Phase 1
34 Cholinergic Agents Phase 2,Phase 1,Not Applicable
35 Botulinum Toxins, Type A Phase 2,Phase 1
36 incobotulinumtoxinA Phase 1
37
Triamcinolone Approved, Vet_approved 124-94-7 31307
38
Nicotine Approved Not Applicable 54-11-5 89594 942
39
tannic acid Approved Not Applicable 1401-55-4
40
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
41
Carbon monoxide Approved, Investigational Not Applicable 630-08-0 281
42
Atosiban Approved, Investigational Not Applicable 90779-69-4
43
Lutein Approved, Investigational, Nutraceutical Not Applicable 127-40-2 6433159
44
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
45
Ginseng Approved, Investigational, Nutraceutical Not Applicable 50647-08-0
46 Liver Extracts
47 Triamcinolone diacetate
48 triamcinolone acetonide
49 Triamcinolone hexacetonide
50
Bisphenol A 80-05-7 6623

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 The Effects of Dexmedetomidine on Early Stage Renal Functions in Pediatric Patients Completed NCT01948336 Phase 4 Dexmedetomidine;Ketamine;Propofol
2 Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE) Completed NCT00456508 Phase 3 ecallantide
3 Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE) Completed NCT00262080 Phase 3 ecallantide;Phosphate Buffer Saline (PBS),
4 Plate Osteosynthesis Versus ESIN of Displaced Midclavicular Fractures Completed NCT01015924 Phase 2, Phase 3
5 Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE) Completed NCT00457015 Phase 3 ecallantide;Phosphate Buffer Saline (PBS), pH 7.0
6 Treatment of Thoracic Outlet Syndrome (TOS) With Botox Completed NCT00444886 Phase 2 Botulinum Toxin Type A injection (BOTOX);Botulinum Toxin Type A injection (BOTOX)
7 Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer Active, not recruiting NCT01898494 Phase 2 cisplatin;carboplatin
8 Botulinum Toxin Injections for Thoracic Outlet Syndrome Unknown status NCT01405482 Phase 1 Botulinum Toxin Type A
9 Study of Serum Levels of Oxidative Stress Markers in Ovarian Hyperstimulation Patients Unknown status NCT02202278
10 Oxidative Stress and Bisphenol A (BPA) Impact With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01600872
11 Impact of JuicePlus+ on the Health Status of an Overweight Stressed Population Unknown status NCT02512107 Not Applicable
12 The Effects of Mindsets on the Brain's Response to Food Cues Unknown status NCT01913743
13 Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging Completed NCT01196637
14 The Effectiveness of Diagnosis and Treatment of Thoracic Outlet Syndrome Completed NCT01342068
15 The Effects of Peep and Tidal Volume on Oxidative Stress in Cardiopulmonary Bypass Surgery Completed NCT03601364
16 Study of Urethral Mobility in Male Stress Urinary Incontinence Pre- and Post- Placement of Transobturator Sling Completed NCT01779323
17 Efficacy of Wet Cupping on Reactive Oxygen Species and Antioxidants Completed NCT03503903 Not Applicable
18 Lung Cancer Informational Study (LCIS) Completed NCT00579215 Not Applicable
19 Consumption of Apple Juice in Hemodialysis Patients Completed NCT02974491 Not Applicable
20 Pharmacokinetic Profile of Toxic Substances and Nicotine in Electronic Cigarettes Completed NCT01665066 Not Applicable
21 Does the Use of Bispectral Index Reduce the Oxidative Stress in Endoscopic Retrograde Cholangiopancreatography? Completed NCT02792751 Not Applicable
22 The Influence of Lutein Supplements on Age-related Macular Degeneration Completed NCT01042860 Not Applicable
23 Carbon Monoxide and Oxidative Stress in Waterpipe Smokers Completed NCT02937415 Not Applicable
24 Surgical Thoracic Outlet Decompression for Neurogenic Thoracic Outlet Syndrome Recruiting NCT03748602 Not Applicable
25 Systematic Transcutaneous Oxymetry Use in Thoracic Outlet Syndrome Recruiting NCT03355274 Not Applicable
26 Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma Recruiting NCT02984410 Not Applicable
27 Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer Recruiting NCT03210103 Not Applicable
28 Synovial Chondrosarcoma: a Single Institution Experience Recruiting NCT03776942
29 A Trial of the Ideal Protein System Versus Low Fat Diet for Weight Loss Recruiting NCT03515889 Not Applicable
30 Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in OSAS Recruiting NCT03268473 Not Applicable
31 Oxidative Stress in Women Treated With Atosiban for Impending Preterm Birth Active, not recruiting NCT03570294 Not Applicable Atosiban
32 Assessment of the Impact of Thoracic Outlet Syndromes on the Performance at Work Not yet recruiting NCT03780647
33 Red Ginseng Extract With Climacteric Symptoms Not yet recruiting NCT03865745 Not Applicable
34 Sleep Disturbances and Biomarkers of Sarcopenic OBesity Not yet recruiting NCT03175601
35 Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome Withdrawn NCT03491930 Not Applicable

Search NIH Clinical Center for Thoracic Outlet Syndrome

Cochrane evidence based reviews: thoracic outlet syndrome

Genetic Tests for Thoracic Outlet Syndrome

Genetic tests related to Thoracic Outlet Syndrome:

# Genetic test Affiliating Genes
1 Abnormality of Toe 30

Anatomical Context for Thoracic Outlet Syndrome

MalaCards organs/tissues related to Thoracic Outlet Syndrome:

42
Brain, Thyroid, Kidney, Skin, T Cells, B Cells, Pituitary

Publications for Thoracic Outlet Syndrome

Articles related to Thoracic Outlet Syndrome:

(show top 50) (show all 1039)
# Title Authors Year
1
Arterial thoracic outlet syndrome caused by cervical ribs-an unusual case report. ( 30882649 )
2019
2
Pan-Asian adapted Clinical Practice Guidelines for the management of patients with metastatic non-small-cell lung cancer: a CSCO-ESMO initiative endorsed by JSMO, KSMO, MOS, SSO and TOS. ( 30596843 )
2019
3
Arteriogenic Thoracic Outlet Syndrome Presenting as Cervical Radiculopathy. ( 30103667 )
2019
4
Intravascular Ultrasound in Venous Thoracic Outlet Syndrome. ( 30217714 )
2019
5
Thoracic Outlet Syndrome Treated With Injecting Botulinum Toxin Into Middle Scalene Muscle and Pectoral Muscle Interfascial Planes: A Case Report. ( 30234514 )
2019
6
Axillary Chest Wall Hibernoma With Intrathoracic Extension Presenting as Thoracic Outlet Syndrome. ( 30399027 )
2019
7
Microvascular Response to the Roos Test Has Excellent Feasibility and Good Reliability in Patients With Suspected Thoracic Outlet Syndrome. ( 30846945 )
2019
8
Thoracic outlet syndrome in a postoperative cervical spondylotic myelopathy patient: A case report. ( 30882659 )
2019
9
Long-term functional outcomes after surgical treatment of nonspecific thoracic outlet syndrome: Retrospective study of 70 cases at a mean of 8 years' follow-up. ( 30940599 )
2019
10
Thoracic Outlet Syndrome: A Comprehensive Review of Pathophysiology, Diagnosis, and Treatment. ( 31037504 )
2019
11
Thoracic Outlet Syndrome Induced by Huge Lipoma: A Case Report. ( 31098353 )
2019
12
Local Anesthetic Block of the Anterior Scalene Muscle Increases Muscle Height in Patients with Neurogenic Thoracic Outlet Syndrome. ( 31009716 )
2019
13
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome. ( 30852035 )
2019
14
Outcomes of Surgical Management of Neurogenic Thoracic Outlet Syndrome: A Systematic Review and Bayesian Perspective. ( 30122304 )
2019
15
Comparison of Athletes and Nonathletes Undergoing Thoracic Outlet Decompression for Neurogenic Thoracic Outlet Syndrome. ( 30081158 )
2019
16
Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic gastric cancer: a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS. ( 30475956 )
2019
17
Percutaneous leadless pacemaker implantation in a patient with bilateral venous thoracic outlet syndrome. ( 29792384 )
2019
18
Thirty-Day Outcomes Following Surgical Decompression of Thoracic Outlet Syndrome. ( 30182746 )
2019
19
Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis. ( 31001703 )
2019
20
A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy. ( 30316081 )
2019
21
Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic oesophageal cancer: a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS. ( 30475943 )
2019
22
Clinical outcomes of end-flexible-rigidscopic transoral surgery (E-TOS) in patients with T1-selected T3 pharyngeal and supraglottic cancers. ( 30789067 )
2019
23
A new species of Miobantia Giglio-Tos, 1917 with a novel morphological feature (Mantodea: Thespidae: Miobantiinae). ( 30790965 )
2019
24
Interplay between synthetic conditions and micromorphology in poly(3,4-ethylenedioxythiophene):tosylate (PEDOT:Tos): an atomistic investigation. ( 30964136 )
2019
25
Arterial thoracic outlet syndrome in Klippel-Feil syndrome. ( 26909867 )
2018
26
A case of symmetric retrograde thromboembolic cerebral infarction in an 8-year-old child due to arterial thoracic outlet syndrome. ( 30019112 )
2018
27
Endovascular Reconstruction of Subclavian Artery Aneurysms in Patients with Arterial Thoracic Outlet Syndrome. ( 30476600 )
2018
28
Cervical Rib Prevalence and its Association with Thoracic Outlet Syndrome: A Meta-Analysis of 141 Studies with Surgical Considerations. ( 29203316 )
2018
29
Cervical rib and the risk for undiagnosed thoracic outlet syndrome. ( 30386039 )
2018
30
Functional Results of Cervical Rib Resection for Thoracic Outlet Syndrome: Impact on Professional Activity. ( 30476612 )
2018
31
Secondary Chondrosarcoma Presenting with Symptoms Similar to Thoracic Outlet Syndrome. ( 29721343 )
2018
32
Thoracic outlet syndrome (TOS): A case report of a rare complication after Nuss procedure for pectus excavatum. ( 30200069 )
2018
33
Intraoperative Neuromonitoring for Brachial Plexus Neurolysis During Delayed Fixation of a Clavicular Fracture Presenting as Thoracic Outlet Syndrome: A Case Report. ( 30601768 )
2018
34
Surgical outcomes of neurogenic thoracic outlet syndrome based on electrodiagnostic tests and QuickDASH scores. ( 30340973 )
2018
35
Neurogenic thoracic outlet syndrome: Bringing order to chaos. ( 30244934 )
2018
36
Amnion membrane improves results in treating neurogenic thoracic outlet syndrome. ( 29942911 )
2018
37
The Gilliatt-Sumner hand: a diagnostic clue of neurogenic thoracic outlet syndrome. ( 29931301 )
2018
38
Outcomes of Transaxillary Approach to Cervical and First-Rib Resection for Neurogenic Thoracic Outlet Syndrome. ( 29772332 )
2018
39
Harvey Cushing's management of neurogenic thoracic outlet syndrome. ( 29652235 )
2018
40
WITHDRAWN: After a motor vehicle accident is it neurogenic thoracic outlet syndrome or ulnar entrapment syndrome? How to make the correct diagnosis. ( 29627065 )
2018
41
Neurogenic Thoracic Outlet Syndrome Caused by Vascular Compression of the Brachial Plexus: A Report of Two Cases. ( 29497457 )
2018
42
Influence of Body Weight on Surgical Treatment for Neurogenic Thoracic Outlet Syndrome. ( 29421422 )
2018
43
Novel Surgical Approach for Decompression of the Scalene Triangle in Neurogenic Thoracic Outlet Syndrome. ( 29396981 )
2018
44
Long-term outcomes after surgical treatment of pediatric neurogenic thoracic outlet syndrome. ( 29125442 )
2018
45
Posterior Upper Rib Excision for Neurogenic Thoracic Outlet Syndrome---Feasibility and Early Outcomes. ( 29106657 )
2018
46
Frequency of the Pectoralis Minor Compression Syndrome in Patients Treated for Thoracic Outlet Syndrome. ( 28943489 )
2018
47
Two-point mDIXON turbo spin-echomagnetic resonance imaging of thoracic outlet syndrome at 3-T for robust fat suppression. ( 29080124 )
2018
48
Safety and Efficacy of Catheter-Directed Therapies as a Supplement to Surgical Decompression in Venous Thoracic Outlet Syndrome. ( 29112470 )
2018
49
T1, T2 paraverterbal blocks provide opioid sparing in first rib resection for thoracic outlet syndrome. ( 29216506 )
2018
50
Dynamic CT angiography for the diagnosis of patients with thoracic outlet syndrome: Correlation with patient symptoms. ( 29233633 )
2018

Variations for Thoracic Outlet Syndrome

Expression for Thoracic Outlet Syndrome

Search GEO for disease gene expression data for Thoracic Outlet Syndrome.

Pathways for Thoracic Outlet Syndrome

GO Terms for Thoracic Outlet Syndrome

Molecular functions related to Thoracic Outlet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SH3 domain binding GO:0017124 8.62 FMN1 SIRPA

Sources for Thoracic Outlet Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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