Thoracic Outlet Syndrome (TOS)

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Thoracic Outlet Syndrome

MalaCards integrated aliases for Thoracic Outlet Syndrome:

Name: Thoracic Outlet Syndrome 12 74 53 58 42 43 15 17 71
Tos 52 58
Thoracic Outlet Compression Syndrome 58
Tos - Thoracic Outlet Syndrome 12
Thoracic Outlet Syndromes 52


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Disease Ontology 12 DOID:3103
MeSH 43 D013901
NCIt 49 C85188
SNOMED-CT 67 128210009
ICD10 32 G54.0
MESH via Orphanet 44 D013901
ICD10 via Orphanet 33 G54.0
UMLS via Orphanet 72 C0039984
Orphanet 58 ORPHA97330
UMLS 71 C0039984

Summaries for Thoracic Outlet Syndrome

NINDS : 53 TOS is an umbrella term that encompasses three related syndromes that involve compression of the nerves, arteries, and veins in the lower neck and upper chest area and cause pain in the arm, shoulder, and neck.  Most doctors agree that TOS is caused by compression of the brachial plexus or subclavian vessels as they pass through narrow passageways leading from the base of the neck to the armpit and arm, but there is considerable disagreement about its diagnosis and treatment. Making the diagnosis of TOS even more difficult is that a number of disorders feature symptoms similar to those of TOS, including rotator cuff injuries, cervical disc disorders, fibromyalgia, multiple sclerosis, complex regional pain syndrome, and tumors of the syrinx or spinal cord.  The disorder can sometimes be diagnosed in a physical exam by tenderness in the supraclavicular area, weakness and/or a "pins and needles" feeling when elevating the hands, weakness in the fifth ("little") finger, and paleness in the palm of one or both hands when the individual raises them above the shoulders, with the fingers pointing to the ceiling.  Symptoms of TOS vary depending on the type. Neurogenic TOS has a characteristic sign, called the Gilliatt-Sumner hand, in which there is severe wasting in the fleshy base of the thumb.  Other symptoms include paresthesias (pins and needles sensation or numbness) in the fingers and hand, change in hand color, hand coldness, or dull aching pain in the neck, shoulder, and armpit.  Venous TOS features pallor, a weak or absent pulse in the affected arm, which also may be cool to the touch and appear paler than the unaffected arm.  Symptoms may include numbness, tingling, aching, swelling of the extremity and fingers, and weakness of the neck or arm.  Arterial TOS most prominently features change in color and cold sensitivity in the hands and fingers, swelling, heaviness, paresthesias and poor blood circulation in the arms, hands, and fingers. There are many causes of TOS, including physical trauma, anatomical defects, tumors that press on nerves, poor posture that causes nerve compression, pregnancy, and repetitive arm and shoulder movements and activity, such as from playing certain sports.   TOS is more common in women.  The onset of symptoms usually occurs between 20 and 50 years of age.  Doctors usually recommend nerve conduction studies, electromyography, or imaging studies to confirm or rule out a diagnosis of TOS.

MalaCards based summary : Thoracic Outlet Syndrome, also known as tos, is related to lemierre's syndrome and thrombophilia due to activated protein c resistance, and has symptoms including seizures, tremor and back pain. An important gene associated with Thoracic Outlet Syndrome is KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, spinal cord and bone, and related phenotypes are paresthesia and muscle weakness

Disease Ontology : 12 A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles.

NIH Rare Diseases : 52 Thoracic outlet syndromes (TOSs) are a group of disorders with one common feature: the compression of 1 or more of the nerves and/or blood vessels just above the first rib and behind the collarbone. There are 4 recognized subtypes of TOS, each with a distinct cause and pattern of symptoms. A fifth subtype is controversial. While thoracic outlet syndromes as a group are not rare, individual subtypes of TOS are considered rare. The subtypes include: Arterial TOS (A-TOS) - due to compression of the subclavian artery , most commonly caused by a cervical rib . Symptoms may include blood clots, arm pain with exertion, or acute arterial thrombosis (sudden blood flow obstruction in an artery). Venous TOS (V-TOS) - due to compression of the subclavian vein , often associated with repetitive arm activities. It may cause pain, swelling, and deep vein thrombosis . Traumatic neurovascular TOS - occurs after trauma to the collarbone and may affect both nerves and vessels. Symptoms may include pain, swelling, bruising, weakness, and loss of sensation in the arm and hand. True neurogenic TOS (TN-TOS) - caused by compression of the brachial plexus . Symptoms include numbness, abnormal sensations, and weakness of the arms and shoulders, as well as pain in the neck, shoulder or hand. Disputed TOS - the vast majority of neurogenic cases. It is controversial whether it is a true form of TOS because it lacks a consistent physical abnormality, a recognized cause, consistent symptoms, a reliable method of testing, and a standard treatment. Pain and tingling or numbness in the neck, arm and hand are common complaints. Treatment for TOS depends on the type and whether symptoms are present. Treatment may involve physical therapy , oral or injected medication (e.g. pain medicine or steroids), thoracic outlet decompression surgery, and/or thrombolytic therapy .

MedlinePlus : 42 Thoracic outlet syndrome (TOS) causes pain in the shoulder, arm, and neck. It happens when the nerves or blood vessels just below your neck are compressed, or squeezed. The compression can happen between the muscles of your neck and shoulder or between the first rib and collarbone. You may feel burning, tingling, and numbness along your arm, hand, and fingers. If a nerve is compressed, you may also feel weakness in your hand. If a vein is compressed, your hand might be sensitive to cold, or turn pale or bluish. Your arm might swell and tire easily. TOS is more common in women. It usually starts between 20 and 50 years of age. Doctors do nerve and imaging studies to diagnose it. There are many causes of TOS, including Injury Anatomical defects Tumors that press on nerves Poor posture that causes nerve compression Pregnancy Repetitive arm and shoulder movements and activity, such as from playing certain sports Treatment depends on what caused your TOS. Medicines, physical therapy, and relaxation might help. Surgery may also be an option. Most people recover. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Thoracic outlet syndrome (TOS) is a condition in which there is compression of the nerves, arteries, or... more...

Related Diseases for Thoracic Outlet Syndrome

Diseases related to Thoracic Outlet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 14059)
# Related Disease Score Top Affiliating Genes
1 lemierre's syndrome 32.8 SERPINC1 F2
2 thrombophilia due to activated protein c resistance 32.3 SERPINC1 PLG PLAT F2
3 antithrombin iii deficiency 32.2 SERPINC1 PLG F2
4 protein s deficiency 32.2 SERPINC1 F2
5 abducens nerve disease 31.8 SERPINC1 F2
6 fournier gangrene 31.8 SERPINC1 F2
7 vitamin k deficiency bleeding 31.7 SERPINC1 F2
8 mastoiditis 31.7 SERPINC1 F2
9 esophageal varix 31.6 SERPINC1 F2
10 endocarditis 31.6 SERPINC1 PLAT F2
11 factor xiii deficiency 31.6 SERPINC1 F2
12 osteonecrosis 31.6 SERPINC1 PLG F2
13 papilledema 31.6 SERPINC1 F2
14 waterhouse-friderichsen syndrome 31.6 SERPINC1 F2
15 prothrombin deficiency 31.6 SERPINC1 F2
16 prothrombin deficiency, congenital 31.6 SERPINC1 F2
17 antiphospholipid syndrome 31.5 SERPINC1 PLAT F2
18 peripheral vascular disease 31.5 SERPINC1 PLAT F2
19 sudden sensorineural hearing loss 31.5 SERPINC1 F2
20 mitral valve stenosis 31.5 SERPINC1 F2
21 cerebral palsy 31.4 SERPINC1 PLAT F2
22 varicose veins 31.4 SERPINC1 PLAT F2
23 spinal cord infarction 31.4 SERPINC1 F2
24 cavernous sinus thrombosis 31.4 SERPINC1 F2
25 splenic infarction 31.3 SERPINC1 PCSK1N F2
26 purpura fulminans 31.3 SERPINC1 F2
27 lipoprotein quantitative trait locus 31.3 PLG PLAT F2
28 bruxism 31.3 WRNIP1 LAPTM4A KCNK6
29 hypersplenism 31.3 SERPINC1 F2
30 moyamoya disease 1 31.2 SERPINC1 PLG F2
31 livedoid vasculitis 31.2 SERPINC1 PLG F2
32 ischemic colitis 31.2 SERPINC1 F2
33 factor vii deficiency 31.2 SERPINC1 F2
34 hemopericardium 31.2 PLG F2
35 leech infestation 31.2 SERPINC1 PLG
36 sneddon syndrome 31.2 SERPINC1 F2
37 pleural empyema 31.1 PLG F2
38 factor xi deficiency 31.1 SERPINC1 F2
39 portal vein thrombosis 31.1 SERPINC1 PLAT F2
40 hepatic coma 30.9 SERPINC1 F2
41 atrial fibrillation 30.9 SERPINC1 PLAT F2
42 conversion disorder 30.9 PLG PLAT
43 hellp syndrome 30.9 SERPINC1 PLAT F2
44 compartment syndrome 30.8 SERPINC1 PLG F2
45 kidney cortex necrosis 30.8 PLG F2
46 argentine hemorrhagic fever 30.8 SERPINC1 PLAT
47 hepatic veno-occlusive disease 30.7 SERPINC1 PLG PLAT
48 dysfibrinogenemia, congenital 30.7 SERPINC1 PLAT F2
49 cholesterol embolism 30.7 SERPINC1 PLG F2
50 hemorrhagic disease 30.7 SERPINC1 PLAT F2

Graphical network of the top 20 diseases related to Thoracic Outlet Syndrome:

Diseases related to Thoracic Outlet Syndrome

Symptoms & Phenotypes for Thoracic Outlet Syndrome

Human phenotypes related to Thoracic Outlet Syndrome:

58 31 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 paresthesia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003401
2 muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0001324
3 edema 58 31 frequent (33%) Frequent (79-30%) HP:0000969
4 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
5 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
6 abnormality of the ribs 58 31 frequent (33%) Frequent (79-30%) HP:0000772
7 emg abnormality 58 31 occasional (7.5%) Occasional (29-5%) HP:0003457
8 venous thrombosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004936
9 varicose veins 58 31 occasional (7.5%) Occasional (29-5%) HP:0002619
10 muscle spasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0003394
11 sensory neuropathy 58 Occasional (29-5%)

UMLS symptoms related to Thoracic Outlet Syndrome:

seizures, tremor, back pain, headache, syncope, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Thoracic Outlet Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 F2 PCSK1N PDSS2 PLAT PLG WRNIP1
2 vision/eye MP:0005391 9.17 LAPTM4A PCSK1N PDSS2 PLAT PLG SERPINC1

Drugs & Therapeutics for Thoracic Outlet Syndrome

Drugs for Thoracic Outlet Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Methylprednisolone Acetate Phase 4
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
10 Neurotransmitter Agents Phase 2
11 abobotulinumtoxinA Phase 2
12 Cholinergic Agents Phase 2
13 Botulinum Toxins Phase 2
14 Botulinum Toxins, Type A Phase 2
15 incobotulinumtoxinA Phase 1
Lidocaine Approved, Vet_approved 137-58-6 3676
Triamcinolone Approved, Vet_approved 124-94-7 31307
Sodium citrate Approved, Investigational 68-04-2
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
20 Immunologic Factors
21 Sodium Channel Blockers
22 Hormones
23 Anesthetics
24 Hormone Antagonists
25 Anti-Arrhythmia Agents
26 Immunosuppressive Agents
27 Triamcinolone diacetate
28 triamcinolone acetonide
29 Triamcinolone hexacetonide
30 Anesthetics, Local
31 glucocorticoids
32 Diuretics, Potassium Sparing
33 Anti-Inflammatory Agents
34 Pharmaceutical Solutions
35 Anticoagulants
36 Citrate

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial Completed NCT03792945 Phase 4 local injection
2 Treatment of Thoracic Outlet Syndrome With Botulinum Toxin Injection: A Double-Blind, Randomized Controlled Trial Completed NCT00444886 Phase 2 Botulinum Toxin Type A injection (BOTOX);Botulinum Toxin Type A injection (BOTOX)
3 Botulin Toxin Type A Injections for Thoracic Outlet Syndrome: A Double-Blind, Randomized Control Trial Unknown status NCT01405482 Phase 1 Botulinum Toxin Type A
4 Thoracic Outlet Syndrome: Case Reports and Analysis - Ultrasound Imaging and Pathomechanics of Brachial Plexus Compression Completed NCT01196637
5 Efficacy of Combined Ultrasound Guided Steroid Injection and Splinting in Patients With Carpal Tunnel Syndrome Completed NCT02708693 Triamcinolone Acetonide;lidocaine hydrochloride
6 Analysis of the Status, Treatment and Outcomes of Rib Fractures Completed NCT02487264
7 The Effectiveness of Diagnosis and Treatment of Thoracic Outlet Syndrome Completed NCT01342068
8 Efficacy of Pulsed Radiofrequency of the Median Nerve Under Ultrasound Guidance in Patients With Carpal Tunnel Syndrome Completed NCT02217293
9 Assessment of the Impact of Thoracic Outlet Syndromes on the Performance at Work Recruiting NCT03780647
10 Application de l'oxymétrie Dynamique Pour le Diagnostic Des Syndromes de défilés Thoraco-brachiaux Systematic Transcutaneous Oxymetry Use in Thoracic Outlet Syndrom Recruiting NCT03355274
11 Computational Fluid Dynamics Analysis for the Risk of Thoracic Outlet Syndrome in Sporty Subjects Recruiting NCT04428125
12 Evaluation Des Mesures Dopplers, Angiographiques, Radiographique Oximetriques, Plethysmographiques, Electromyographiques et Des Questionnaires Cliniques Des Patients adressés Pour Suspicion de Syndrome du défilé Thoraco-brachial Recruiting NCT04376177
13 Surgical Thoracic Outlet Decompression Versus Conservative Approach for Patients With Neurogenic Thoracic Outlet Syndrome, a Randomized Controlled Trial Recruiting NCT03748602
14 Neurogenic Thoracic Outlet Syndrome and Other Forms of Cervical Brachial Syndrome Treated With Plasma Concentrate Enriched for Alpha 2 Macroglobulin Enrolling by invitation NCT04066933
15 Outpatient Office Based Endovascular Procedures Enrolling by invitation NCT04054440
16 Evaluation of the Muscular FORCE in the Upper Limbs of Patients Presenting a Thoracic Outlet Syndrome : Monocentric Case-control Study Not yet recruiting NCT04145778
17 Bloc Des Muscles Erecteurs du Rachis Pour Chirurgie d'exérèse de première côte Dans le Cadre du Syndrome du défilé Cervico-thoracique: évaluation Avant-après au CHU d'Angers. Not yet recruiting NCT04167046

Search NIH Clinical Center for Thoracic Outlet Syndrome

Cochrane evidence based reviews: thoracic outlet syndrome

Genetic Tests for Thoracic Outlet Syndrome

Anatomical Context for Thoracic Outlet Syndrome

MalaCards organs/tissues related to Thoracic Outlet Syndrome:

Testes, Spinal Cord, Bone, Brain, Lung, Breast, Bone Marrow

Publications for Thoracic Outlet Syndrome

Articles related to Thoracic Outlet Syndrome:

(show top 50) (show all 1713)
# Title Authors PMID Year
Venous pectoralis minor syndrome: a rare subdivision of the thoracic outlet syndrome. 42 61
31873744 2020
Supraclavicular excision of a cervical rib for treatment of thoracic outlet syndrome. 42 61
31869006 2019
Thoracic outlet syndrome: a narrative review. 61 42
31859722 2019
The thoracic outlet syndromes: Part 1. Overview of the thoracic outlet syndromes and review of true neurogenic thoracic outlet syndrome. 61 52
28006844 2017
The thoracic outlet syndromes: Part 2. The arterial, venous, neurovascular, and disputed thoracic outlet syndromes. 52
28006856 2017
Transthoracic Robotic First Rib Resection: Technique Crystallized. 61
32105717 2020
The effects of head posture on nerve conduction studies in patients with ankylosing spondylitis. 61
31292936 2020
Cervical Rib Synostosis to the First Rib: A Rare Anatomic Variation. 61
32169617 2020
The Safety of Blood Flow Restriction Training as a Therapeutic Intervention for Patients With Musculoskeletal Disorders: A Systematic Review. 61
31710505 2020
Special Communication: Evaluation and Treatment of Thoracic Outlet Syndrome During the Global Pandemic Due to SARS-CoV-2 and COVID-19. 61
32497747 2020
First rib resection by VATS for thoracic outlet syndrome. 61
32520451 2020
Posterior cerebral artery stroke by reverse flow embolism in thoracic outlet syndrome - a case report. 61
32498705 2020
Thoracic Outlet Syndrome in the Overhead Athlete: Diagnosis and Treatment Recommendations. 61
32514995 2020
Comments on: "Thoracic Outlet Syndrome: Diagnostic accuracy of MRI" of A. Hardy, C. Pougès, G. Wavreille, H. Behal, X. Demondion, G. Lefebvre published in Orthop Traumatol Surg Res OTSR. 2019;105(8):1563-9. 61
32439276 2020
Comments on: "Thoracic outlet syndrome: diagnostic accuracy of MRI" of A Hardy, C Pougès, G Wavreille, H Behal, X Demondion, G Lefebvre published in Orthop Traumatol Surg Res OTSR. 2019;105(8):1563-9. 61
32507587 2020
Posteriorly displaced salter halter fracture-dislocation at the sternoclavicular joint with associated thoracic outlet syndrome: A case report. 61
32553937 2020
A Surgical View of Anatomy: Perspectives from Students and Instructors. 61
32515172 2020
Postoperative outcomes in thoracic outlet decompression for acute versus chronic venous thoracic outlet syndrome. 61
32464288 2020
Miscarriage is associated with cervical ribs in thoracic outlet syndrome patients. 61
32247157 2020
Sonographically guided botulinum toxin injections in patients with neurogenic thoracic outlet syndrome: correlation with surgical outcomes. 61
31807876 2020
Value of Ultrasound in the Diagnosis of Neurogenic Thoracic Outlet Syndrome. 61
32199700 2020
Supraclavicular Versus Transaxillary First Rib Resection for Thoracic Outlet Syndrome. 61
32412829 2020
Robotic First Rib Resection for Thoracic Outlet Syndrome. 61
31821522 2020
Venous Thoracic Outlet Syndrome in a Young Student. 61
32471745 2020
Manubrial pseudolesion: a secondary sign of thoracic outlet syndrome. 61
32464509 2020
ACR Appropriateness Criteria® Thoracic Outlet Syndrome. 61
32370976 2020
Supraclavicular Resection of a Cervical Rib Causing Thoracic Outlet Syndrome: 2-Dimensional Operative Video. 61
32445569 2020
Robotic-Assisted First Rib Resection: Our Experience and Review of the Literature. 61
32446920 2020
A pilot study of forearm microvascular impairment and pain while using a telephone. 61
31790665 2020
Costoclavicular ligament as a novel cause of venous thoracic outlet syndrome: from anatomic study to clinical application. 61
32424683 2020
Efficacy of intensive, hospital-based rehabilitation in cases of thoracic outlet syndrome that failed to respond to private-practice physiotherapy. 61
32444532 2020
Deploying Airbag in Motor Vehicle Collision as the Mechanism of Neurogenic Thoracic Outlet Syndrome: A Case Report. 61
32417284 2020
Infraclavicular Thoracic Outlet Decompression Compared to Supraclavicular Thoracic Outlet Decompression for the Management of Venous Thoracic Outlet Syndrome. 61
31678546 2020
Effects of kinesio taping on pain, paresthesia, functional status, and overall health status in patients with symptomatic thoracic outlet syndrome: A single-blind, randomized, placebo-controlled study. 61
32442118 2020
Aspiration thrombectomy for the management of acute deep venous thrombosis in the setting of venous thoracic outlet syndrome. 61
31888420 2020
Infrequent origin of a peripheral embolism: Arterial thoracic outlet syndrome in a young woman. 61
32281956 2020
Recurrent acute limb ischaemia and thoracic outlet syndrome secondary to a clavicle fracture malunion. 61
32267993 2020
Spinal Cord Stimulation for Neurogenic Thoracic Outlet Syndrome: A Case Report. 61
32224698 2020
Ultrasound for Neurogenic Thoracic Outlet Obstruction Remains Theoretical. 61
32272795 2020
A critical overview of the current myofascial pain literature - January 2020. 61
32507147 2020
The Adipofascial Deltopectoral Flap to Cover the Brachial Plexus in Thoracic Outlet Syndrome and Radiation Plexitis. 61
32467081 2020
Minimally Invasive Resection of Symptomatic Cervical Rib for Treatment of Thoracic Outlet Syndrome. 61
32194276 2020
Paget-Schroetter syndrome in pregnancy: A case report and discussion of management options. 61
32072090 2020
Computed tomography venography of the upper extremities - Using low dose bilateral contrast media injection in a patient with suspected venous thoracic outlet syndrome. 61
31969969 2020
Neurogenic Thoracic Outlet Syndrome and other Forms of Cervical Brachial Syndrome Treated with Plasma Concentrate Enriched for Alpha 2 Macroglobulin. 61
32214305 2020
Thirty-year experience of transaxillary resection of first rib for thoracic outlet syndrome. 61
31814380 2020
Paget-Schroetter Syndrome: a case report of diagnosis, treatment, and outcome in a healthy 18-year-old athletic swimmer. 61
31903806 2020
Early and Late Outcomes of Surgery for Neurogenic Thoracic Outlet Syndrome in Adolescents. 61
31626925 2020
Differences in quality of life outcomes after paraclavicular decompression for thoracic outlet syndrome. 61
32115317 2020
Measurement of Outlet Pressures Favors Rib Resection for Decompression of Thoracic Outlet Syndrome. 61
32045585 2020

Variations for Thoracic Outlet Syndrome

Expression for Thoracic Outlet Syndrome

Search GEO for disease gene expression data for Thoracic Outlet Syndrome.

Pathways for Thoracic Outlet Syndrome

GO Terms for Thoracic Outlet Syndrome

Cellular components related to Thoracic Outlet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 SERPINC1 PLG F2
2 collagen-containing extracellular matrix GO:0062023 8.92 SERPINC1 PLG PLAT F2

Biological processes related to Thoracic Outlet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 SERPINC1 PLG F2
2 blood coagulation GO:0007596 9.46 SERPINC1 PLG PLAT F2
3 hemostasis GO:0007599 9.43 SERPINC1 PLG F2
4 negative regulation of proteolysis GO:0045861 9.4 PLAT F2
5 regulation of blood coagulation GO:0030193 9.37 SERPINC1 F2
6 negative regulation of fibrinolysis GO:0051918 9.32 PLG F2
7 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 8.96 PLG PLAT
8 fibrinolysis GO:0042730 8.8 PLG PLAT F2

Molecular functions related to Thoracic Outlet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 PLG PLAT F2
2 serine-type peptidase activity GO:0008236 9.13 PLG PLAT F2
3 signaling receptor binding GO:0005102 8.92 PLG PLAT PCSK1N F2

Sources for Thoracic Outlet Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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