Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: THR035
MIFTS: 46

Thrombasthenia

Categories: Blood diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Thrombasthenia

About this section

MalaCards integrated aliases for Thrombasthenia:

Name: Thrombasthenia 53 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 73 C0040015
Sources

Summaries for Thrombasthenia

About this section
MalaCards based summary : Thrombasthenia is related to glanzmann thrombasthenia and bleeding disorder, platelet-type, 16. An important gene associated with Thrombasthenia is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways/superpathways are Integrin Pathway and PI3K-Akt signaling pathway. The drugs Fludarabine and Vidarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related phenotypes are cardiovascular system and cellular

Sources

Related Diseases for Thrombasthenia

About this section

Diseases related to Thrombasthenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 glanzmann thrombasthenia 33.5 F2 F3 GP1BA GP9 ITGA2 ITGA2B
2 bleeding disorder, platelet-type, 16 32.6 ITGA2B ITGB3
3 bernard-soulier syndrome 30.5 F2 GP1BA GP9 ITGA2 ITGA2B ITGB3
4 von willebrand's disease 30.3 F2 F3 F5 GP1BA SELP
5 purpura 30.2 F2 F3 ITGA2B ITGB3
6 thrombocytopenia 30.2 F3 GP1BA GP9 ITGA2 ITGA2B ITGB3
7 prothrombin deficiency, congenital 30.0 F2 F5
8 prothrombin deficiency 30.0 F2 F3
9 thrombophilia due to thrombin defect 29.8 F2 F3 F5 MTHFR
10 thrombosis 29.8 F2 F3 F5 GP1BA MTHFR SELP
11 thrombocytopenia due to platelet alloimmunization 29.7 GP9 ITGA2 ITGA2B ITGB3 SELP
12 blood platelet disease 29.6 F2 F3 GP1BA GP9 ITGA2B ITGB3
13 bleeding disorder, platelet-type, 17 11.8
14 schlegelberger grote syndrome 11.4
15 leukocyte adhesion deficiency, type i 11.1
16 congenital disorder of glycosylation, type iic 11.1
17 leukocyte adhesion deficiency, type iii 11.1
18 aspirin resistance 10.2 ITGA2 ITGB3
19 paracetamol poisoning 10.2 F2 F5
20 chancroid 10.2 CD36 VTN
21 sticky platelet syndrome 10.2 F5 ITGB3
22 autosomal dominant macrothrombocytopenia 10.2 GP1BA ITGA2B ITGB3
23 cerebral falx meningioma 10.2 F2 F3
24 hemoglobin e disease 10.2 F2 F5
25 leech infestation 10.2 F2 F3
26 infective endocarditis 10.2 F2 GP1BA ITGB3
27 intestinal impaction 10.1 F2 F3
28 fournier gangrene 10.1 F2 F3
29 acquired hemophilia 10.1 F3 F5
30 inferior vena cava interruption 10.1 F5 MTHFR
31 mesenteric vascular occlusion 10.1 F2 MTHFR
32 acquired hemophilia a 10.1 F3 F5
33 amaurosis fugax 10.1 F5 MTHFR
34 giant hemangioma 10.1 F2 F3
35 factor vii deficiency 10.1 EGF F2 F3
36 hemophilia b 10.1 EGF F2 F3
37 fetal and neonatal alloimmune thrombocytopenia 10.1 GP1BA ITGA2 ITGA2B ITGB3
38 cerebral sinovenous thrombosis 10.1 F2 F3 F5
39 sagittal sinus thrombosis 10.1 F2 F3 F5
40 buerger disease 10.1 F2 ITGA2 MTHFR
41 peripheral vertigo 10.1 F2 F3 F5
42 factor x deficiency 10.1 F2 F3 F5
43 spinal cord infarction 10.1 F2 F5 MTHFR
44 afibrinogenemia 10.1 F2 F3 F5
45 factor v deficiency 10.1 F2 F3 F5
46 carotid artery thrombosis 10.1 F3 ITGA2B SELP
47 coronary thrombosis 10.1 F3 GP1BA ITGB3
48 gray platelet syndrome 10.1 CD36 GP9 SELP
49 cryptogenic cirrhosis 10.1 F2 F5 MTHFR
50 porencephaly 10.1 F2 F5 MTHFR

Graphical network of the top 20 diseases related to Thrombasthenia:



Diseases related to Thrombasthenia
Sources

Symptoms & Phenotypes for Thrombasthenia

About this section

MGI Mouse Phenotypes related to Thrombasthenia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.24 CD36 F2 F3 F5 HPSE ITGA2B
2 cellular MP:0005384 10.22 CD36 F3 GP1BA HPSE ITGA2 ITGA2B
3 hematopoietic system MP:0005397 10.22 CD36 F2 F3 GP1BA GP9 HPSE
4 homeostasis/metabolism MP:0005376 10.18 CD36 F2 F3 F5 GP1BA ITGA2
5 growth/size/body region MP:0005378 10.17 CD36 EGF F2 F3 F5 ITGB3
6 immune system MP:0005387 10.02 CD36 EGF F2 F3 HPSE ITGA2B
7 digestive/alimentary MP:0005381 10 CD36 EGF F2 ITGA2B ITGB3 PTK2
8 integument MP:0010771 10 EGF F2 F3 F5 HPSE ITGA2
9 liver/biliary system MP:0005370 9.76 CD36 F5 ITGB3 MTHFR PSMG1 PTK2
10 nervous system MP:0003631 9.65 CD36 F2 F3 F5 ITGB3 MTHFR
11 normal MP:0002873 9.23 EGF F2 F3 ITGA2 ITGB3 PSMG1
Sources

Drugs & Therapeutics for Thrombasthenia

About this section

Drugs for Thrombasthenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 2,Not Applicable 75607-67-9, 21679-14-1 30751
2
Vidarabine Approved, Investigational Phase 2 24356-66-9 32326 21704
3
Cyclophosphamide Approved, Investigational Phase 2,Not Applicable 6055-19-2, 50-18-0 2907
4 Antineoplastic Agents, Alkylating Phase 2
5 Vidarabine Phosphate Phase 2
6 Antiviral Agents Phase 2
7 Alkylating Agents Phase 2
8 Antimetabolites, Antineoplastic Phase 2
9 Antimetabolites Phase 2
10 Anti-Infective Agents Phase 2
11 Immunosuppressive Agents Phase 2,Phase 1
12 Antirheumatic Agents Phase 2,Phase 1
13 Immunologic Factors Phase 2,Phase 1
14
Abatacept Approved Phase 1 332348-12-6 10237
15
Mycophenolic acid Approved Phase 1 24280-93-1 446541
16 Cyclosporins Phase 1
17
Aspirin Approved, Vet_approved 50-78-2 2244
18
Iron Approved Not Applicable 7439-89-6 23925
19
Busulfan Approved, Investigational Not Applicable 55-98-1 2478
20
alemtuzumab Approved, Investigational Not Applicable 216503-57-0
21 Antifibrinolytic Agents
22 Hemostatics
23 Krestin
24 Anti-Bacterial Agents
25 Adjuvants, Immunologic
26 Radiation-Protective Agents
27 Antibodies
28 Antibiotics, Antitubercular
29 Immunoglobulins
30 Antibodies, Monoclonal
31 Platelet Aggregation Inhibitors
32 Protective Agents
33 interferons
34 Interferon Inducers
35 Antilymphocyte Serum Not Applicable
36 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer Recruiting NCT03333486 Phase 2 Cyclophosphamide;Fludarabine Phosphate
2 Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male Subjects Completed NCT01561417 Phase 1 activated recombinant human factor VII;activated recombinant human factor VII
3 BMT Abatacept for Non-Malignant Diseases Active, not recruiting NCT01917708 Phase 1 Abatacept
4 Evaluation of Menses in Congenital Bleeding Disorders Unknown status NCT01261936
5 Observational Registry of the Treatment of Glanzmann's Thrombasthenia Completed NCT01476423 activated recombinant human factor VII
6 A Study to Evaluate Safety and Efficacy of NovoSeven® in Patients With Glanzmann's Thrombasthenia in Japan Completed NCT01876745 eptacog alfa (activated)
7 Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in Germany Completed NCT00697320 eptacog alfa (activated)
8 The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders. Recruiting NCT00230165
9 Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity Recruiting NCT03648190
10 Clinical Performance Evaluation of T-TAS 01 PL Chip Recruiting NCT03621020
11 Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of Platelets Recruiting NCT01957345 Not Applicable
12 Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies Recruiting NCT02179359 Not Applicable Reduced Toxicity Ablative Regimen;Reduced Intensity Preparative Regimen;Myeloablative Preparative Regimen
13 Prospective, Non-interventional Study to Evaluate Immunogenicity of AryoSeven Enrolling by invitation NCT03372993
14 Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT01319851 Not Applicable Alefacept

Search NIH Clinical Center for Thrombasthenia

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Thrombasthenia

About this section
Sources

Anatomical Context for Thrombasthenia

About this section

MalaCards organs/tissues related to Thrombasthenia:

41
Bone, Bone Marrow, Myeloid, Liver, Heart, Spinal Cord, Thyroid
Sources

Publications for Thrombasthenia

About this section

Articles related to Thrombasthenia:

(show top 50) (show all 623)
# Title Authors Year
1
Acquired Antibodies to I+IIbI^3 in Glanzmann Thrombasthenia: From Transfusion and Pregnancy to Bone Marrow Transplants and Beyond. ( 29884513 )
2018
2
Levonorgestrel-releasing intrauterine system for treatment of heavy menstrual bleeding in adolescents with Glanzmann's Thrombasthenia: illustrated case series. ( 29486748 )
2018
3
In silico analysis of structural modifications in and around the integrin I+IIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia. ( 29385657 )
2018
4
Study of the Relationship between HPA-1 and HPA-5 Gene Polymorphisms and Refractory to Platelet Therapy and Recombinant Factor VII in Glanzmann Thrombasthenia Patients in Southeast of Iran. ( 29951177 )
2018
5
Anti-I+<sub>IIb</sub> I^<sub>3</sub> immunization in Glanzmann thrombasthenia: review of literature and treatment recommendations. ( 29611179 )
2018
6
Clinical and molecular insights into Glanzmann's thrombasthenia in China. ( 29675921 )
2018
7
Alloimmunization in Congenital Deficiencies of Platelet Surface Glycoproteins: Focus on Glanzmann's Thrombasthenia and Bernard-Soulier's Syndrome. ( 29879742 )
2018
8
ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia. ( 29125375 )
2018
9
A novel variant Glanzmann thrombasthenia due to co-inheritance of a loss- and a gain-of-function mutation of ITGB3: evidence of a dominant effect of gain-of-function mutations. ( 29439184 )
2018
10
Management of Abdominoperineal Excision of the Rectum in a Patient with Glanzmann Thrombasthenia. ( 29945125 )
2018
11
Perioperative management of a patient with Glanzmann thrombasthenia undergoing a coronary artery bypass graft surgery: a case report. ( 29474205 )
2018
12
Correction of coagulopathy in thrombocytopenia and Glanzmann thrombasthenia models by fibrinogen and factor XIII as assessed by thromboelastometry. ( 29805054 )
2018
13
Combination of acquired von Willebrand syndrome (AVWS) and Glanzmann thrombasthenia in monoclonal gammopathy of uncertain significance (MGUS), a case report. ( 30534006 )
2018
14
Multidisciplinary Clinical Management of a Localized Aggressive Periodontitis diagnosed in a Child with Glanzmann's Thrombasthenia. ( 30397380 )
2018
15
How we treat the platelet glycoprotein defects; Glanzmann thrombasthenia and Bernard Soulier syndrome in children and adults. ( 30117143 )
2018
16
Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia. ( 29985398 )
2018
17
A novel approach using ancillary tests to guide treatment of Glanzmann thrombasthenia patients undergoing surgical procedures. ( 30078718 )
2018
18
From thrombasthenia to next generation thrombocytopenia: Neonatal alloimmune thrombocytopenia induced by maternal Glanzmann thrombasthenia. ( 30216638 )
2018
19
Molecular genetic diagnosis of Tunisian Glanzmann thrombasthenia patients reveals a common nonsense mutation in the ITGA2B gene that seems to be specific for the studied population. ( 30325339 )
2018
20
A unique phenotype of acquired Glanzmann thrombasthenia due to non-function-blocking anti-αIIbβ3 autoantibodies. ( 30388316 )
2018
21
Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease. ( 30551951 )
2018
22
Identification of Clinicopathological Spectrum, Platelet Glycoprotein IIb/IIIa complex and Platelet Antibodies in Egyptian Children with Glanzmann's Thrombasthenia. ( 28161816 )
2017
23
Molecular characterization of Glanzmann's thrombasthenia in Iran: identification of three novel mutations. ( 29084015 )
2017
24
A rare case of bleeding disorder: Glanzmann's thrombasthenia. ( 29063905 )
2017
25
Epistaxis as a Common Presenting Symptom of Glanzmann's Thrombasthenia, a Rare Qualitative Platelet Disorder: Illustrative Case Examples. ( 28299211 )
2017
26
Allogeneic hematopoietic cell transplantation in an adult patient with Glanzmann thrombasthenia. ( 29152293 )
2017
27
Perioperative management of a patient with glanzmann's thrombasthenia for mitral valve repair under cardiopulmonary bypass. ( 28994690 )
2017
28
Novel Mutations in Thai Patients with Glanzmann Thrombasthenia. ( 28888044 )
2017
29
Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses? ( 28395882 )
2017
30
Anticoagulant therapy in patients with Glanzmann's Thrombasthenia: Is it possible? ( 28940852 )
2017
31
Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. ( 28078347 )
2017
32
Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann's Thrombasthenia. ( 28670433 )
2017
33
Oral Surgery in Patients With Glanzmann Thrombasthenia: A Case Series. ( 28341450 )
2017
34
Evaluation of platelet surface glycoproteins in patients with Glanzmann thrombasthenia: Association with bleeding symptoms. ( 28948953 )
2017
35
Reversal of Glanzmann thrombasthenia platelet phenotype after imatinib treatment in a pediatric chronic myeloid leukemia patient. ( 29185819 )
2017
36
Independent adjudicator assessments of platelet refractoriness and rFVIIa efficacy in bleeding episodes and surgeries from the multinational Glanzmann's thrombasthenia registry. ( 28370369 )
2017
37
Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions. ( 28466602 )
2017
38
Recognition and management of platelet-refractory bleeding in patients with Glanzmann's thrombasthenia and other severe platelet function disorders. ( 28435309 )
2017
39
Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression. ( 28232155 )
2017
40
Emergency craniotomy in Glanzmann thrombasthenia: Anesthetic management and brief review of literature. ( 28096593 )
2016
41
Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia. ( 26452979 )
2016
42
Immunisation against I+IIbI^3 and I+vI^3 in a type 1 variant of Glanzmann's thrombasthenia caused by a missense mutation Gly540Asp on I^3. ( 27098940 )
2016
43
Identification and Characterization of Glanzmann Thrombasthenia in 2 Closely Related Mixed-breed Dogs. ( 26764135 )
2016
44
Linkage disequilibrium amongst ITGA2B and ITGB3 gene variants in patients with Glanzmann thrombasthenia confirms that most disease-causing mutations are recent. ( 27469266 )
2016
45
Perioperative ROTEM and ROTEMplatelet monitoring in a case of Glanzmann's thrombasthenia. ( 26825624 )
2016
46
Glanzmann Thrombasthenia: A Clinicopathological Profile. ( 27539755 )
2016
47
Glanzmann thrombasthenia in a child manifesting after dengue infection. ( 28050106 )
2016
48
New Insights Into the Treatment of Glanzmann Thrombasthenia. ( 26968829 )
2016
49
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? ( 27352634 )
2016
50
Endometriosis and GlanzmannA9s thrombasthenia. ( 27655515 )
2016
Sources

Variations for Thrombasthenia

About this section
Sources

Expression for Thrombasthenia

About this section
Search GEO for disease gene expression data for Thrombasthenia.
Sources

Pathways for Thrombasthenia

About this section

Pathways related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.33 CD36 EGF F2 ITGA2 ITGA2B ITGB3
2
PI3K-Akt signaling pathway 37
Show member pathways
 12.94 EGF ITGA2 ITGA2B ITGB3 PTK2 VTN
3
Focal Adhesion 1 37
Show member pathways
 12.82 EGF ITGA2 ITGA2B ITGB3 PTK2 VTN
4
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.81 CD36 EGF F2 F3 F5 GP1BA
5
Regulation of actin cytoskeleton 1 37
12.54 EGF F2 ITGA2 ITGA2B ITGB3 PTK2
6
VEGF Pathway (Qiagen) 22
Show member pathways
 12.35 EGF ITGB3 PTK2 VTN
7
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 37
Show member pathways
 12.34 EGF ITGA2 ITGA2B ITGB3 PTK2
8
Proteoglycans in cancer 37
12.21 HPSE ITGA2 ITGB3 PTK2 VTN
9
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.17 F2 ITGA2 ITGA2B ITGB3 PTK2
10
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.14 ITGA2 ITGA2B ITGB3 PTK2
11
AKT Signaling Pathway 67
12.08 ITGA2 ITGA2B ITGB3 PTK2
12
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 12.06 F2 F3 F5 GP1BA GP9
13
Complement and coagulation cascades 1 37
12.03 F2 F3 F5 VTN
14
L1CAM interactions 66
Show member pathways
 11.95 ITGA2 ITGA2B ITGB3
15
Adhesion 4
11.94 F3 ITGB3 PTK2
16
Platelet activation 37
11.89 GP1BA GP9 ITGA2 ITGA2B ITGB3
17
ECM-receptor interaction 37
Show member pathways
 11.88 CD36 GP1BA GP9 ITGA2 ITGA2B ITGB3
18
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.83 CD36 GP1BA ITGA2 ITGA2B ITGB3
19
Small cell lung cancer 37
11.81 ITGA2 ITGA2B PTK2
20
Integrin alphaIIb beta3 signaling 66
Show member pathways
 11.79 F2 GP1BA GP9 ITGA2B ITGB3 PTK2
21
Phagocytosis of Microbes 64
11.75 ITGA2 ITGA2B ITGB3 VTN
22
Hematopoietic cell lineage 37
11.72 CD36 GP1BA GP9 ITGA2 ITGA2B ITGB3
23
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.69 ITGB3 PTK2 VTN
24
G-protein signaling_RhoA regulation pathway 22
11.65 EGF ITGA2 ITGA2B ITGB3 PTK2
25
Non-integrin membrane-ECM interactions 66
Show member pathways
 11.64 ITGA2 ITGB3 VTN
26
IL4-mediated signaling events 1
11.61 GTF3A ITGB3 SELP
27
Signaling events mediated by PTP1B 1
11.49 EGF ITGA2B ITGB3
28
ECM proteoglycans 66
11.49 ITGA2 ITGA2B ITGB3 VTN
29
Cytoskeleton remodeling_RalA regulation pathway 22
11.48 ITGA2 ITGA2B ITGB3 PTK2
30
amb2 Integrin signaling 1
11.47 GP1BA SELP VTN
31
Hematopoietic Stem Cell Differentiation 1
11.46 GP9 ITGA2B ITGB3
32
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms 22
11.38 ITGA2 ITGB3 VTN
33
G-protein signaling_Cross-talk between Ras-family GTPases 22
11.34 ITGA2 ITGA2B ITGB3 PTK2
34
Articular Cartilage Extracellular Matrix Pathway 65
11.3 HPSE ITGA2 ITGA2B
35
Arf6 signaling events 1
11.26 EGF ITGA2B ITGB3
36
G-protein signaling_Rap2B regulation pathway 22
10.97 EGF ITGA2 ITGA2B ITGB3 PTK2
37
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
10.81 CD36 F2 GP9 ITGA2 ITGA2B ITGB3
38
Platelet Adhesion to exposed collagen 66
10.77 GP1BA GP9 ITGA2
39
MFAP5-mediated ovarian cancer cell motility and invasiveness 1
10.74 ITGB3 PTK2
40
GP1b-IX-V activation signalling 66
10.65 GP1BA GP9
Sources

GO Terms for Thrombasthenia

About this section

Cellular components related to Thrombasthenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 CD36 EGF F2 F3 F5 GP1BA
2 cell surface GO:0009986 9.73 CD36 F3 GP1BA ITGA2 ITGA2B ITGB3
3 external side of plasma membrane GO:0009897 9.72 CD36 F2 ITGA2 ITGA2B SELP
4 alphav-beta3 integrin-vitronectin complex GO:0071062 9.16 ITGB3 VTN
5 integrin complex GO:0008305 9.13 ITGA2 ITGA2B ITGB3
6 platelet alpha granule membrane GO:0031092 8.92 CD36 ITGA2B ITGB3 SELP
7 plasma membrane GO:0005886 10.18 CD36 EGF F2 F3 F5 GP1BA

Biological processes related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.85 EGF F3 HPSE PTK2
2 extracellular matrix organization GO:0030198 9.85 ITGA2 ITGA2B ITGB3 PTK2 VTN
3 platelet activation GO:0030168 9.83 F2 GP1BA GP9 ITGB3
4 integrin-mediated signaling pathway GO:0007229 9.81 ITGA2 ITGA2B ITGB3 PTK2
5 wound healing GO:0042060 9.78 HPSE ITGA2 ITGB3
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 CD36 EGF ITGB3 VTN
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 F2 PTK2 SELP
8 cell-matrix adhesion GO:0007160 9.72 HPSE ITGA2 ITGA2B ITGB3 VTN
9 platelet aggregation GO:0070527 9.71 GP1BA ITGA2B ITGB3
10 cell adhesion mediated by integrin GO:0033627 9.67 ITGA2 ITGB3 VTN
11 hemostasis GO:0007599 9.65 F2 F3 F5 GP1BA GP9
12 positive regulation of smooth muscle cell migration GO:0014911 9.63 ITGA2 VTN
13 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.63 ITGB3 VTN
14 platelet degranulation GO:0002576 9.63 CD36 EGF F5 ITGA2B ITGB3 SELP
15 apoptotic cell clearance GO:0043277 9.62 CD36 ITGB3
16 cell-substrate adhesion GO:0031589 9.62 ITGA2 ITGB3
17 positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 9.61 EGF PTK2
18 blood coagulation, intrinsic pathway GO:0007597 9.61 F2 GP1BA GP9
19 cell adhesion GO:0007155 9.61 CD36 GP1BA GP9 HPSE ITGA2 ITGA2B
20 mesodermal cell differentiation GO:0048333 9.6 ITGA2 ITGB3
21 regulation of blood coagulation GO:0030193 9.59 F2 GP1BA
22 positive regulation of positive chemotaxis GO:0050927 9.58 F3 ITGA2
23 angiogenesis involved in wound healing GO:0060055 9.58 HPSE ITGB3
24 positive regulation of blood coagulation GO:0030194 9.58 CD36 F2 HPSE
25 positive regulation of phagocytosis, engulfment GO:0060100 9.57 CD36 ITGA2
26 positive regulation of leukocyte migration GO:0002687 9.54 ITGA2 ITGA2B SELP
27 blood coagulation GO:0007596 9.23 CD36 F2 F3 F5 GP1BA GP9

Molecular functions related to Thrombasthenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinogen binding GO:0070051 9.16 ITGA2B ITGB3
2 thrombospondin receptor activity GO:0070053 8.96 CD36 F2
3 extracellular matrix binding GO:0050840 8.8 ITGA2B ITGB3 VTN
4 protein binding GO:0005515 10.16 CD36 EGF F2 F3 F5 GP1BA
Sources

Sources for Thrombasthenia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....