MCID: THR035
MIFTS: 41

Thrombasthenia

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Thrombasthenia

MalaCards integrated aliases for Thrombasthenia:

Name: Thrombasthenia 52 71

Classifications:



External Ids:

UMLS 71 C0040015

Summaries for Thrombasthenia

MalaCards based summary : Thrombasthenia is related to bleeding disorder, platelet-type, 16 and glanzmann thrombasthenia. An important gene associated with Thrombasthenia is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways/superpathways are Integrin Pathway and PI3K-Akt signaling pathway. The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, myeloid and testes, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Thrombasthenia

Diseases related to Thrombasthenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 bleeding disorder, platelet-type, 16 33.6 ITGB3 ITGA2B
2 glanzmann thrombasthenia 30.6 VTN THRA THCAT158 SELP PTK2 ITGB3
3 autosomal dominant macrothrombocytopenia 30.6 ITGB3 ITGA2B GP1BA
4 factor viii deficiency 30.5 F5 F3 F2
5 factor vii deficiency 30.4 F3 F2 EGF
6 hemorrhagic disease 30.4 GP1BA F5 F3 F2
7 prothrombin deficiency 30.3 F3 F2
8 hemopericardium 30.3 F3 F2
9 fetal and neonatal alloimmune thrombocytopenia 30.2 ITGB3 ITGA2B ITGA2 GP1BA
10 factor xiii deficiency 30.1 F5 F3 F2
11 factor xi deficiency 30.1 F5 F3 F2
12 active peptic ulcer disease 30.0 F3 F2
13 disseminated intravascular coagulation 30.0 F5 F3 F2
14 qualitative platelet defect 29.9 ITGA2B GP1BA F3 F2
15 thrombophilia due to thrombin defect 29.9 MTHFR F5 F3 F2
16 purpura 29.8 SELP ITGB3 ITGA2B GP1BA F3 F2
17 thrombocytopenia due to platelet alloimmunization 29.7 SELP ITGB3 ITGA2B ITGA2 GP9
18 pulmonary embolism 29.6 MTHFR F5 F3 F2
19 acquired von willebrand syndrome 29.4 GP1BA F3
20 gray platelet syndrome 29.4 SELP ITGA2B GP9 CD36
21 bernard-soulier syndrome 29.4 SELP ITGB3 ITGA2B ITGA2 GP9 GP1BA
22 thrombocytosis 29.4 SELP F3 F2
23 thrombocytopenic purpura, autoimmune 29.3 SELP ITGB3 ITGA2B GP1BA
24 von willebrand's disease 28.8 SELP ITGB3 ITGA2 GP9 GP1BA F5
25 blood platelet disease 28.8 SELP ITGB3 ITGA2B ITGA2 GP9 GP1BA
26 thrombophilia 28.7 SELP MTHFR ITGB3 F5 F3 F2
27 thrombocytopenia 28.2 SELP ITGB3 ITGA2B ITGA2 HPSE GP9
28 thrombosis 28.1 SELP MTHFR ITGB3 ITGA2B ITGA2 GP1BA
29 myocardial infarction 27.5 SELP MTHFR ITGB3 ITGA2B ITGA2 GP1BA
30 vascular disease 27.3 VTN SELP MTHFR ITGB3 ITGA2B ITGA2
31 bleeding disorder, platelet-type, 17 12.0
32 leukocyte adhesion deficiency, type i 11.6
33 schlegelberger grote syndrome 11.5
34 congenital disorder of glycosylation, type iic 11.2
35 leukocyte adhesion deficiency, type iii 11.2
36 autosomal recessive disease 10.5
37 malignant gastric germ cell tumor 10.5 ITGB3 ITGA2B
38 aspirin resistance 10.5 ITGB3 ITGA2
39 gastric teratoma 10.5 ITGB3 ITGA2B
40 gastric hemangioma 10.4 F3 F2
41 paracetamol poisoning 10.4 F5 F2
42 fournier gangrene 10.4 F3 F2
43 sticky platelet syndrome 10.4 ITGB3 F5
44 synovial angioma 10.4 F3 F2
45 renal pelvis squamous cell carcinoma 10.4 F3 F2
46 blue toe syndrome 10.4 F3 F2
47 papillary adenofibroma 10.4 F3 F2
48 emphysematous cholecystitis 10.4 F3 F2
49 dic in newborn 10.4 F3 F2
50 hepatic infarction 10.4 F3 F2

Graphical network of the top 20 diseases related to Thrombasthenia:



Diseases related to Thrombasthenia

Symptoms & Phenotypes for Thrombasthenia

MGI Mouse Phenotypes related to Thrombasthenia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 CD36 F2 F3 F5 HPSE ITGA2B
2 hematopoietic system MP:0005397 10.18 CD36 F2 F3 GP1BA GP9 HPSE
3 cellular MP:0005384 10.17 CD36 F3 GP1BA HPSE ITGA2 ITGA2B
4 homeostasis/metabolism MP:0005376 10.17 CD36 F2 F3 F5 GP1BA HPSE
5 integument MP:0010771 10 EGF F2 F3 F5 HPSE ITGA2
6 digestive/alimentary MP:0005381 9.95 CD36 EGF F2 ITGA2B ITGB3 PTK2
7 liver/biliary system MP:0005370 9.76 CD36 F5 ITGB3 MTHFR PSMG1 PTK2
8 normal MP:0002873 9.56 EGF F2 F3 ITGA2 ITGB3 PSMG1
9 vision/eye MP:0005391 9.23 CD36 EGF F3 ITGB3 MTHFR PSMG1

Drugs & Therapeutics for Thrombasthenia

Drugs for Thrombasthenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
3
Vidarabine Approved, Investigational Phase 2 24356-66-9 32326 21704
4
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
5 Antirheumatic Agents Phase 2
6 Immunologic Factors Phase 2
7 Immunosuppressive Agents Phase 2
8 Alkylating Agents Phase 2
9 Anti-Infective Agents Phase 2
10 Antiviral Agents Phase 2
11 Antimetabolites Phase 2
12 Vidarabine Phosphate Phase 2
13
Abatacept Approved Phase 1 332348-12-6 10237
14
Mycophenolic acid Approved Phase 1 24280-93-1 446541
15 Cyclosporins Phase 1
16
Iron Approved, Experimental 7439-89-6, 15438-31-0 23925 27284
17
Busulfan Approved, Investigational 55-98-1 2478
18
alemtuzumab Approved, Investigational 216503-57-0
19
Aspirin Approved, Vet_approved 50-78-2 2244
20
Ticagrelor Approved 274693-27-5 9871419
21
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
22
Sodium citrate Approved, Investigational 68-04-2
23
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
24 Antifibrinolytic Agents
25 Hemostatics
26 Antilymphocyte Serum
27 Anti-Inflammatory Agents
28 Fibrinolytic Agents
29 Platelet Aggregation Inhibitors
30 Analgesics, Non-Narcotic
31 Anti-Inflammatory Agents, Non-Steroidal
32 Antipyretics
33 Cyclooxygenase Inhibitors
34 Analgesics
35 Anti-Bacterial Agents
36 Antibodies, Monoclonal
37 interferons
38 Antibiotics, Antitubercular
39 Adjuvants, Immunologic
40 Protective Agents
41 polysaccharide-K
42 Radiation-Protective Agents
43 Interferon Inducers
44 Immunoglobulins
45 Antibodies
46 Citrate
47 Factor VIII
48 Dermatologic Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Phase II Trial of Haploidentical Allogeneic Stem Cell Transplantation Utilizing Mobilized Peripheral Blood Stem Cells Recruiting NCT03333486 Phase 2 Cyclophosphamide;Fludarabine Phosphate
2 A Single-centre, Randomised, Double-blind, Two-way Cross-over Trial Investigating the Bio-equivalence in Healthy Male Subjects of NovoSeven (CP-rFVIIa) and a Formulation of NovoSeven Stable at 25°C (VII25) Completed NCT01561417 Phase 1 activated recombinant human factor VII;activated recombinant human factor VII
3 Abatacept for Post-Transplant Immune Suppression in Children and Adolescents Receiving Allogeneic Hematopoietic Stem Cell Transplants for Non-Malignant Diseases Active, not recruiting NCT01917708 Phase 1 Abatacept
4 A Post-Marketing, Observational Study in Iran to Determine the Immunogenicity Status in Patients Who Have Received rFVIIa AryoSeven. Unknown status NCT03372993
5 A Multicentre, Non-interventional, Observational Study to Evaluate Safety and Efficacy of NovoSeven® in Patients With Glanzmann's Thrombasthenia in Japan Completed NCT01876745 eptacog alfa (activated)
6 Efficacy of NovoSeven® (Activated Recombinant Human Factor VII): Non-interventional Study in Patients With Congenital Haemophilia With Inhibitors, Acquired Haemophilia, Factor FVII Deficiency, and Glanzmann's Thrombasthenia Completed NCT00697320 eptacog alfa (activated)
7 Treatment of Glanzmann's Thrombasthenia: A Prospective Observational Registry Completed NCT01476423 activated recombinant human factor VII
8 Multicentre Evaluation of a New Laboratory Approach for the Diagnosis of Constitutional Functional Disorders of Platelets Completed NCT01957345
9 Studies of Interactions Among Normal and Abnormal Blood Cells, and the Vessel Wall, and Studies of Genetic and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell and Coagulation Disorders Recruiting NCT00230165
10 MT2014-10C: Allogeneic Hematopoietic Stem Cell Transplant for Patients With High Risk Hemoglobinopathies and Other Red Cell Transfusion Dependent Disorders Recruiting NCT02179359 Reduced Toxicity Ablative Regimen;Reduced Intensity Preparative Regimen;Myeloablative Preparative Regimen
11 Clinical Performance Evaluation of T-TAS 01 PL Chip Recruiting NCT03621020
12 Evaluation of Platelet Surface Glycoproteins in Patients With Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity Recruiting NCT03648190
13 Interest of Sublingual Videomicroscopy for the Prediction of Bleeding in Von Willebrand Disease and Other Constitutional Haemorrhagic Diseases Not yet recruiting NCT04119908
14 Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation for Children With Non-Malignant Diseases Who Have Been Multiply Transfused: a Pilot Study Terminated NCT01319851 Alefacept

Search NIH Clinical Center for Thrombasthenia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


recombinant FVIIa

Genetic Tests for Thrombasthenia

Anatomical Context for Thrombasthenia

MalaCards organs/tissues related to Thrombasthenia:

40
Bone, Myeloid, Testes, Bone Marrow, Whole Blood, Heart, Liver

Publications for Thrombasthenia

Articles related to Thrombasthenia:

(show top 50) (show all 1289)
# Title Authors PMID Year
1
Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction. 61
31691484 2020
2
A rare case of Glanzmann's thrombasthenia and factor VII deficiency due to a combination of pathogenic and non-pathogenic gene variants. 61
31777146 2020
3
Menstrual and obstetrical bleeding in women with inherited platelet receptor defects-A systematic review. 61
32004416 2020
4
Clinico-hematological and thromboelastographic profiles in glanzmann's thrombasthenia. 61
31789664 2020
5
Acquired Glanzmann's thrombasthenia: Diagnosis aided by platelet aggregation mixing study. 61
31985103 2020
6
Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets. 61
31905839 2019
7
Rituximab for treatment of autoimmune acquired platelet function disorders: description of two cases of acquired Glanzmann thrombasthenia and one case of acquired delta storage pool disease. 61
31612461 2019
8
Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications. 61
31826978 2019
9
Acquired Glanzmann thrombasthenia associated with platelet desialylation. 61
31869497 2019
10
A Glanzmann thrombasthenia family associated with a TUBB1-related macrothrombocytopenia. 61
31565851 2019
11
A Successful Renal Transplant in a Pediatric Patient With Glanzmann Thrombasthenia and Hyperimmunization. 61
31580240 2019
12
Prevalence of the Mutations Responsible for Glanzmann Thrombasthenia in Horses in Brazil. 61
31766112 2019
13
Successful Use of Hematopoietic Stem Cell Transplantation for 2 Pediatric Cases of Glanzmann Thrombasthenia and Review of the Literature. 61
31693514 2019
14
Unique case of successful surgical treatment of recurrent spinal epidural hematoma after lumbar disc surgery in a Glanzmann thrombasthenia patient. 61
31621418 2019
15
Ribociclib Causing Transient Glanzmann Thrombasthenia-like Picture: A Report of 4 Cases. 61
31311720 2019
16
Triple jeopardy: A case of Glanzmann's thrombasthenia with anti-GPIIb-IIIa antibodies and HPA incompatibility resulting in stillbirth. 61
31404847 2019
17
Sphenopalatine Artery Ligation for Life-Threatening Epistaxis in a 4-Year-Old Child With Glanzmann Thrombasthenia. 61
31079481 2019
18
The International Prospective Glanzmann Thrombasthenia Registry: Pediatric Treatment and Outcomes. 61
31523745 2019
19
The use of prophylaxis in the treatment of rare bleeding disorders. 61
31420204 2019
20
Acquired Glanzmann thrombasthenia: From antibodies to anti-platelet drugs. 61
31010659 2019
21
Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen. 61
30934104 2019
22
Intraventricular hemorrhage in ICSI twin pregnant woman with thrombasthenia: A rare case report. 61
30898627 2019
23
High-throughput elucidation of thrombus formation reveals sources of platelet function variability. 61
30545925 2019
24
Identification of one novel pathogenic ITGB3 mutation and two known mutations in two Chinese pedigrees with hereditary Glanzmann thrombasthenia. 61
31088191 2019
25
First description of an IgM monoclonal antibody causing αIIb β3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia. 61
30868743 2019
26
Molecular genetic diagnosis of Glanzmann syndrome in Iranian population; reporting novel and recurrent mutations. 61
31029159 2019
27
Glanzmann Thrombasthenia in Children: Experience From a Tertiary Care Center in Southern India. 61
30789846 2019
28
Glanzmann Thrombasthenia in a Newborn with Heterozygous Factor V Leiden and Heterozygous MTHFR C677T Gene Mutations. 61
30819996 2019
29
Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease. 61
30551951 2019
30
Abdominal Surgical Emergencies in Patients with Hematological Disorders: An Exacting Experience for Surgeons. 61
31007975 2019
31
Effects of a novel low volume resuscitation solutions on coagulation and platelet function. 61
31042735 2019
32
Flow cytometry for pediatric platelets. 61
30285517 2019
33
Screening for platelet function disorders with Multiplate and platelet function analyzer. 61
29135309 2019
34
Management of Dentoalveolar Trauma in a 3-year-old Child with Glanzmann's Thrombasthenia, a Rare Bleeding Disorder: Case Report and Review. 61
32015657 2019
35
An Unusual Cause of Bleeding in a Patient with Chronic Myeloid Leukemia Chronic Phase. 61
31583142 2019
36
Thrombotic events with recombinant activated factor VII (rFVIIa) in approved indications are rare and associated with older age, cardiovascular disease, and concomitant use of activated prothrombin complex concentrates (aPCC). 61
31572039 2019
37
A unique phenotype of acquired Glanzmann thrombasthenia due to non-function-blocking anti-αIIbβ3 autoantibodies. 61
30388316 2019
38
Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients. 61
30597506 2019
39
Molecular yield of targeted sequencing for Glanzmann thrombasthenia patients. 61
30792900 2019
40
Oral tranexamic acid associated with platelet transfusion to prevent hemorrhage in a patient with Glanzmann thrombasthenia. 61
30644834 2019
41
Perioperative Hemostatic Management of a Pediatric Patient with Glanzmann Thrombasthenia Undergoing Osteoplastic Craniotomy and Hematoma Removal: A Case Report. 61
31085914 2019
42
Correction of coagulopathy in thrombocytopenia and Glanzmann thrombasthenia models by fibrinogen and factor XIII as assessed by thromboelastometry. 61
29805054 2018
43
Molecular genetic diagnosis of Tunisian Glanzmann thrombasthenia patients reveals a common nonsense mutation in the ITGA2B gene that seems to be specific for the studied population. 61
30325339 2018
44
From thrombasthenia to next generation thrombocytopenia: Neonatal alloimmune thrombocytopenia induced by maternal Glanzmann thrombasthenia. 61
30216638 2018
45
Inherited Bleeding Disorders in the Obstetric Patient. 61
30097224 2018
46
[The clinical characteristics and molecular pathogenesis of a variant Glanzmann's thrombasthenia-like pedigree]. 61
30369200 2018
47
Inherited Bleeding Disorders in Iraq and Consanguineous Marriage. 61
30774827 2018
48
Alloimmunization in Congenital Deficiencies of Platelet Surface Glycoproteins: Focus on Glanzmann's Thrombasthenia and Bernard-Soulier's Syndrome. 61
29879742 2018
49
Inherited platelet disorders : Management of the bleeding risk. 61
30077511 2018
50
How we treat the platelet glycoprotein defects; Glanzmann thrombasthenia and Bernard Soulier syndrome in children and adults. 61
30117143 2018

Variations for Thrombasthenia

Expression for Thrombasthenia

Search GEO for disease gene expression data for Thrombasthenia.

Pathways for Thrombasthenia

Pathways related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 VTN PTK2 ITGB3 ITGA2B ITGA2 F2
2
Show member pathways
12.93 VTN PTK2 ITGB3 ITGA2B ITGA2 EGF
3
Show member pathways
12.81 VTN PTK2 ITGB3 ITGA2B ITGA2 EGF
4
Show member pathways
12.81 SELP PTK2 ITGB3 ITGA2B ITGA2 GP9
5 12.77 PTK2 ITGA2B ITGA2 F2 EGF
6
Show member pathways
12.77 PTK2 ITGB3 ITGA2B ITGA2 F2
7
Show member pathways
12.62 PTK2 ITGB3 ITGA2B ITGA2 EGF
8 12.54 PTK2 ITGB3 ITGA2B ITGA2 F2 EGF
9
Show member pathways
12.52 VTN PTK2 ITGB3 ITGA2
10
Show member pathways
12.43 VTN PTK2 ITGB3 ITGA2
11
Show member pathways
12.35 VTN PTK2 ITGB3 EGF
12 12.22 VTN PTK2 ITGB3 ITGA2 HPSE
13
Show member pathways
12.16 PTK2 ITGB3 ITGA2B ITGA2
14
Show member pathways
12.06 GP9 GP1BA F5 F3 F2
15 12.05 VTN F5 F3 F2
16 11.94 ITGB3 ITGA2B ITGA2 GP9 GP1BA F2
17
Show member pathways
11.89 VTN ITGB3 ITGA2B ITGA2 GP9 GP1BA
18 11.87 ITGB3 ITGA2B ITGA2 GP1BA CD36
19 11.81 PTK2 ITGA2B ITGA2
20 11.79 ITGB3 ITGA2B ITGA2 GP9 GP1BA CD36
21 11.75 VTN ITGB3 ITGA2B ITGA2
22
Show member pathways
11.73 PTK2 ITGB3 ITGA2B GP9 GP1BA F2
23 11.69 VTN PTK2 ITGB3
24 11.65 PTK2 ITGB3 ITGA2B ITGA2 EGF
25 11.61 SELP ITGB3 GTF3A
26 11.49 ITGB3 ITGA2B EGF
27 11.49 VTN ITGB3 ITGA2B ITGA2
28 11.48 PTK2 ITGB3 ITGA2B ITGA2
29 11.46 ITGB3 ITGA2B GP9
30 11.46 VTN SELP GP1BA
31 11.35 VTN ITGB3 ITGA2
32 11.28 ITGA2B ITGA2 HPSE
33 11.24 ITGB3 ITGA2B EGF
34 10.96 PTK2 ITGB3 ITGA2B ITGA2 EGF
35 10.81 ITGB3 ITGA2B ITGA2 GP9 F2 CD36
36 10.77 ITGA2 GP9 GP1BA
37 10.73 PTK2 ITGB3
38 10.65 GP9 GP1BA

GO Terms for Thrombasthenia

Cellular components related to Thrombasthenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.18 SELP PTK2 ITGB3 ITGA2B ITGA2 GP9
2 extracellular space GO:0005615 9.97 VTN SELP GP1BA F5 F3 F2
3 cell surface GO:0009986 9.73 ITGB3 ITGA2B ITGA2 GP1BA F3 CD36
4 external side of plasma membrane GO:0009897 9.72 SELP ITGA2B ITGA2 F2 CD36
5 alphav-beta3 integrin-vitronectin complex GO:0071062 9.16 VTN ITGB3
6 integrin complex GO:0008305 9.13 ITGB3 ITGA2B ITGA2
7 platelet alpha granule membrane GO:0031092 8.92 SELP ITGB3 ITGA2B CD36

Biological processes related to Thrombasthenia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.88 VTN PTK2 ITGB3 ITGA2B ITGA2
2 positive regulation of protein kinase B signaling GO:0051897 9.85 PTK2 HPSE F3 EGF
3 platelet activation GO:0030168 9.83 ITGB3 GP9 GP1BA F2
4 integrin-mediated signaling pathway GO:0007229 9.81 PTK2 ITGB3 ITGA2B ITGA2
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 VTN ITGB3 EGF CD36
6 wound healing GO:0042060 9.78 ITGB3 ITGA2 HPSE
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 SELP PTK2 F2
8 cell-matrix adhesion GO:0007160 9.72 VTN ITGB3 ITGA2B ITGA2 HPSE
9 platelet aggregation GO:0070527 9.71 ITGB3 ITGA2B GP1BA
10 hemostasis GO:0007599 9.65 GP9 GP1BA F5 F3 F2
11 cell adhesion mediated by integrin GO:0033627 9.63 VTN ITGB3 ITGA2
12 platelet degranulation GO:0002576 9.63 SELP ITGB3 ITGA2B F5 EGF CD36
13 cell-substrate adhesion GO:0031589 9.62 ITGB3 ITGA2
14 positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 9.61 PTK2 EGF
15 blood coagulation, intrinsic pathway GO:0007597 9.61 GP9 GP1BA F2
16 cell adhesion GO:0007155 9.61 VTN SELP ITGB3 ITGA2B ITGA2 HPSE
17 mesodermal cell differentiation GO:0048333 9.6 ITGB3 ITGA2
18 positive regulation of phagocytosis, engulfment GO:0060100 9.58 ITGA2 CD36
19 positive regulation of positive chemotaxis GO:0050927 9.58 ITGA2 F3
20 positive regulation of blood coagulation GO:0030194 9.58 HPSE F2 CD36
21 regulation of blood coagulation GO:0030193 9.57 GP1BA F2
22 angiogenesis involved in wound healing GO:0060055 9.56 ITGB3 HPSE
23 positive regulation of leukocyte migration GO:0002687 9.54 SELP ITGA2B ITGA2
24 blood coagulation GO:0007596 9.23 ITGB3 ITGA2 GP9 GP1BA F5 F3

Molecular functions related to Thrombasthenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.46 THRA MTHFR ITGA2 CD36
2 fibrinogen binding GO:0070051 8.96 ITGB3 ITGA2B
3 thrombospondin receptor activity GO:0070053 8.62 F2 CD36

Sources for Thrombasthenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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