MCID: THR116
MIFTS: 24

Thrombocytopenia, Cyclic

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Thrombocytopenia, Cyclic

MalaCards integrated aliases for Thrombocytopenia, Cyclic:

Name: Thrombocytopenia, Cyclic 57 55 73
Cyclic Thrombocytopenia 53
Thrombocytopenia Cyclic 53

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
thrombocytopenia, cyclic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 188020
MedGen 42 C0272282
UMLS 73 C0272282

Summaries for Thrombocytopenia, Cyclic

MalaCards based summary : Thrombocytopenia, Cyclic, also known as cyclic thrombocytopenia, is related to thrombocytopenia and thrombocytosis. An important gene associated with Thrombocytopenia, Cyclic is THPO (Thrombopoietin). Affiliated tissues include testes, neutrophil and t cells, and related phenotypes are abnormal bleeding and thrombocytopenia

Description from OMIM: 188020

Related Diseases for Thrombocytopenia, Cyclic

Diseases related to Thrombocytopenia, Cyclic via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 10.3
2 thrombocytosis 10.1
3 thrombocytopenic purpura, autoimmune 9.8
4 myasthenia gravis 9.8
5 polycythemia vera 9.8
6 dengue virus 9.8
7 common variable immunodeficiency 9.8
8 human venous malformation 9.8
9 vitamin b12 deficiency 9.8
10 purpura 9.8
11 polycythemia 9.8
12 myasthenia gravis congenital 9.8

Graphical network of the top 20 diseases related to Thrombocytopenia, Cyclic:



Diseases related to Thrombocytopenia, Cyclic

Symptoms & Phenotypes for Thrombocytopenia, Cyclic

Symptoms via clinical synopsis from OMIM:

57
Heme:
thrombocytopenia
bleeding diathesis
cyclic neutropenia


Clinical features from OMIM:

188020

Human phenotypes related to Thrombocytopenia, Cyclic:

32
# Description HPO Frequency HPO Source Accession
1 abnormal bleeding 32 HP:0001892
2 thrombocytopenia 32 HP:0001873
3 neutropenia 32 HP:0001875
4 cyclic neutropenia 32 HP:0040289

Drugs & Therapeutics for Thrombocytopenia, Cyclic

Search Clinical Trials , NIH Clinical Center for Thrombocytopenia, Cyclic

Genetic Tests for Thrombocytopenia, Cyclic

Anatomical Context for Thrombocytopenia, Cyclic

MalaCards organs/tissues related to Thrombocytopenia, Cyclic:

41
Testes, Neutrophil, T Cells

Publications for Thrombocytopenia, Cyclic

Articles related to Thrombocytopenia, Cyclic:

(show all 42)
# Title Authors Year
1
Cyclic thrombocytopenia with statistically significant neutrophil oscillations. ( 29988661 )
2018
2
Cyclic thrombocytopenia synchronizing with the menstrual cycle showing periodic phases of thrombocytopenia and rebound thrombocytosis. ( 28413179 )
2017
3
Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge. ( 28518476 )
2017
4
Cyclic thrombocytopenia related to menstrual cycle: a case report and literature review. ( 25419404 )
2014
5
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. ( 22038676 )
2012
6
Cyclic thrombocytopenia: A case report. ( 27263605 )
2010
7
Successful treatment of cyclic thrombocytopenia with thrombopoietin-mimetic agents: a report of two patients. ( 19484732 )
2009
8
Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia. ( 19728020 )
2009
9
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP. ( 17135540 )
2006
10
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. ( 16044437 )
2005
11
Human cyclic thrombocytopenia and Anaplasma spp. infection. ( 15654914 )
2005
12
Investigation of persistent hypochromic microcytosis unmasks hemoglobin Evanston [alpha 14 (A12) Try--> Arg] in a patient of cyclic thrombocytopenia preceding Takayasu's disease. ( 16273737 )
2005
13
Idiopathic cyclic thrombocytopenia. ( 15572217 )
2005
14
Is complete remission of cyclic thrombocytopenia related to correction of cobalamin deficiency due to H. pylori eradication? ( 15650554 )
2005
15
Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. ( 15205594 )
2004
16
Cyclic thrombocytopenia and polycythemia vera. ( 12574969 )
2003
17
Clonal T cell-mediated cyclic thrombocytopenia. ( 12472588 )
2002
18
Effective treatment of cyclic thrombocytopenia with cepharanthin. ( 10530079 )
1999
19
Cyclic thrombocytopenia in a patient treated with cyclosporine for refractory idiopathic thrombocytopenic purpura. ( 9395191 )
1997
20
Clinical manifestations of infectious canine cyclic thrombocytopenia. ( 9308149 )
1997
21
Serum thrombopoietin levels in cyclic thrombocytopenia. ( 8639873 )
1996
22
Cyclic change of cytokines in a patient with cyclic thrombocytopenia. ( 8757531 )
1996
23
Canine infectious cyclic thrombocytopenia found in Taiwan. ( 8741613 )
1996
24
Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis. ( 7496073 )
1995
25
Megakaryopoiesis in patients with cyclic thrombocytopenia. ( 7577630 )
1995
26
Cyclic thrombocytopenia successfully treated with low dose hormonal contraception. ( 7832199 )
1995
27
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. ( 7871984 )
1994
28
Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies. ( 7529542 )
1994
29
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function. ( 7918035 )
1993
30
Periodic production of antiplatelet autoantibody directed against GPIIIa in cyclic thrombocytopenia. ( 8362605 )
1993
31
[A case of myasthenia gravis complicated by cyclic thrombocytopenia]. ( 1628457 )
1992
32
Danazol therapy for cyclic thrombocytopenia. ( 2012064 )
1991
33
Cell-mediated cyclic thrombocytopenia treated with azathioprine. ( 2012761 )
1991
34
Cyclic thrombocytopenia of apparent autoimmune etiology. ( 2713494 )
1989
35
Idiopathic cyclic thrombocytopenia of childhood. ( 2712241 )
1989
36
Menstrual cyclic thrombocytopenia. ( 2713272 )
1989
37
Serologic diagnosis of infectious cyclic thrombocytopenia in dogs using an indirect fluorescent antibody test. ( 6362502 )
1983
38
Cyclic thrombocytopenia induced by a Rickettsia-like agent in dogs. ( 627738 )
1978
39
Cyclic thrombocytopenia. Case report and review of literature. ( 4598703 )
1974
40
Cyclic thrombocytopenia: a thrombopoietin deficiency? ( 4832304 )
1974
41
Cyclic thrombocytopenia associated with multiple autoantibodies. ( 5797783 )
1969
42
Cyclic thrombocytopenia of acute type. ( 4295269 )
1967

Variations for Thrombocytopenia, Cyclic

Expression for Thrombocytopenia, Cyclic

Search GEO for disease gene expression data for Thrombocytopenia, Cyclic.

Pathways for Thrombocytopenia, Cyclic

GO Terms for Thrombocytopenia, Cyclic

Sources for Thrombocytopenia, Cyclic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....