MCID: THR116
MIFTS: 21

Thrombocytopenia, Cyclic

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Thrombocytopenia, Cyclic

MalaCards integrated aliases for Thrombocytopenia, Cyclic:

Name: Thrombocytopenia, Cyclic 57 54 70
Cyclic Thrombocytopenia 20
Thrombocytopenia Cyclic 20

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
thrombocytopenia, cyclic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 188020
MedGen 41 C0272282
UMLS 70 C0272282

Summaries for Thrombocytopenia, Cyclic

MalaCards based summary : Thrombocytopenia, Cyclic, also known as cyclic thrombocytopenia, is related to thrombocytopenia and thrombocytosis. An important gene associated with Thrombocytopenia, Cyclic is THPO (Thrombopoietin). Affiliated tissues include neutrophil, and related phenotypes are thrombocytopenia and neutropenia

More information from OMIM: 188020

Related Diseases for Thrombocytopenia, Cyclic

Graphical network of the top 20 diseases related to Thrombocytopenia, Cyclic:



Diseases related to Thrombocytopenia, Cyclic

Symptoms & Phenotypes for Thrombocytopenia, Cyclic

Human phenotypes related to Thrombocytopenia, Cyclic:

31
# Description HPO Frequency HPO Source Accession
1 thrombocytopenia 31 HP:0001873
2 neutropenia 31 HP:0001875
3 abnormal bleeding 31 HP:0001892
4 cyclic neutropenia 31 HP:0040289

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Heme:
thrombocytopenia
cyclic neutropenia
bleeding diathesis

Clinical features from OMIM®:

188020 (Updated 05-Apr-2021)

Drugs & Therapeutics for Thrombocytopenia, Cyclic

Search Clinical Trials , NIH Clinical Center for Thrombocytopenia, Cyclic

Genetic Tests for Thrombocytopenia, Cyclic

Anatomical Context for Thrombocytopenia, Cyclic

MalaCards organs/tissues related to Thrombocytopenia, Cyclic:

40
Neutrophil

Publications for Thrombocytopenia, Cyclic

Articles related to Thrombocytopenia, Cyclic:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Garcia's disease. Cyclic thrombocytopenic purpura in a child and abnormal platelet counts in his family. 57 61
557235 1977
2
Cyclic thrombocytopenia: a thrombopoietin deficiency? 57 61
4832304 1974
3
Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia. 54 61
19728020 2009
4
How I manage cyclic thrombocytopenia. 61
33197928 2021
5
Molecular Prevalence and Identification of Ehrlichia canis and Anaplasma platys from Dogs in Nay Pyi Taw Area, Myanmar. 61
33628413 2021
6
A Blueprint for Identifying Phenotypes and Drug Targets in Complex Disorders with Empirical Dynamics. 61
33336196 2020
7
Vector competence of Rhipicephalus sanguineus sensu stricto for Anaplasma platys. 61
32993937 2020
8
Periodic hematological disorders: Quintessential examples of dynamical diseases. 61
32611100 2020
9
Clinical and laboratory characteristics of cyclic thrombocytopenia: an observational study. 61
31974196 2020
10
Cyclic thrombocytopenia with statistically significant neutrophil oscillations. 61
29988661 2018
11
Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib. 61
30057831 2018
12
Normal and pathological dynamics of platelets in humans. 61
28391511 2017
13
Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge. 61
28518476 2017
14
Cyclic thrombocytopenia synchronizing with the menstrual cycle showing periodic phases of thrombocytopenia and rebound thrombocytosis. 61
28413179 2017
15
Multiple infections of Anaplasma platys variants in Philippine dogs. 61
28096621 2016
16
Molecular detection of Anaplasma species in dogs in Colombia. 61
27925061 2016
17
Anaplasma platys Immunoblot Test Using Major Surface Antigens. 61
27327629 2016
18
Molecular detection and characterization of Anaplasma platys in dogs and ticks in Cuba. 61
27132516 2016
19
Molecular identification and characterization of Anaplasma platys and Ehrlichia canis in dogs in Mexico. 61
26615872 2016
20
Molecular detection of Anaplasma platys infection in free-roaming dogs and ticks from Kenya and Ivory Coast. 61
26984538 2016
21
First identification of Anaplasma platys in the blood of dogs from French Guiana. 61
25700049 2015
22
Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes. 61
24750292 2014
23
Detection of Anaplasma platys in dogs and Rhipicephalus sanguineus group ticks by a quantitative real-time PCR. 61
25027609 2014
24
Detection of Anaplasma platys in dogs using real-time loop-mediated isothermal amplification. 61
24508323 2014
25
Cyclic thrombocytopenia related to menstrual cycle: a case report and literature review. 61
25419404 2014
26
Natural infection of Anaplasma platys in dogs from Umbria region (Central Italy). 61
24715593 2014
27
First evidence of Anaplasma platys and Hepatozoon canis co-infection in a dog from Romania--a case report. 61
23528989 2013
28
First description of natural Ehrlichia canis and Anaplasma platys infections in dogs from Argentina. 61
23273677 2013
29
First case of Anaplasma platys infection in a dog from Croatia. 61
22401583 2012
30
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. 61
22038676 2012
31
Cloning of the major outer membrane protein expression locus in Anaplasma platys and seroreactivity of a species-specific antigen. 61
21498646 2011
32
Cyclic thrombocytopenia: A case report. 61
27263605 2010
33
Successful treatment of cyclic thrombocytopenia with thrombopoietin-mimetic agents: a report of two patients. 61
19484732 2009
34
[Cross-reaction evaluation of PCR-Anaplasma platys positive dogs tested to Anaplasma phagocytophilum antibodies by commercial ELISA]. 61
20059806 2008
35
[Cyclic thrombocytopenia complicated with Sjögren syndrome and the mechanism of periodic platelet count fluctuation]. 61
18800616 2008
36
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP. 61
17135540 2006
37
Investigation of persistent hypochromic microcytosis unmasks hemoglobin Evanston [alpha 14 (A12) Try--> Arg] in a patient of cyclic thrombocytopenia preceding Takayasu's disease. 61
16273737 2005
38
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. 61
16044437 2005
39
Juvenile cyclic amegakaryocytic thrombocytopenia: a novel entity. 61
15750447 2005
40
Human cyclic thrombocytopenia and Anaplasma spp. infection. 61
15654914 2005
41
Idiopathic cyclic thrombocytopenia. 61
15572217 2005
42
Is complete remission of cyclic thrombocytopenia related to correction of cobalamin deficiency due to H. pylori eradication? 61
15650554 2005
43
Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. 61
15205594 2004
44
[Thrombocytopenia due to deficient platelet production]. 61
12718078 2003
45
Cyclic thrombocytopenia and polycythemia vera. 61
12574969 2003
46
Clonal T cell-mediated cyclic thrombocytopenia. 61
12472588 2002
47
Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. 61
11754405 2001
48
Severe cyclical thrombocytopenia in a patient with a large lymphatic-venous malformation: a potential association? 61
11233720 2001
49
Effective treatment of cyclic thrombocytopenia with cepharanthin. 61
10530079 1999
50
[Cyclic thrombocytopenia]. 61
9833506 1998

Variations for Thrombocytopenia, Cyclic

Expression for Thrombocytopenia, Cyclic

Search GEO for disease gene expression data for Thrombocytopenia, Cyclic.

Pathways for Thrombocytopenia, Cyclic

GO Terms for Thrombocytopenia, Cyclic

Sources for Thrombocytopenia, Cyclic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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