MCID: THR116
MIFTS: 24

Thrombocytopenia, Cyclic

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Thrombocytopenia, Cyclic

MalaCards integrated aliases for Thrombocytopenia, Cyclic:

Name: Thrombocytopenia, Cyclic 58 56 74
Cyclic Thrombocytopenia 54
Thrombocytopenia Cyclic 54

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
thrombocytopenia, cyclic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 188020
MedGen 43 C0272282
UMLS 74 C0272282

Summaries for Thrombocytopenia, Cyclic

MalaCards based summary : Thrombocytopenia, Cyclic, also known as cyclic thrombocytopenia, is related to thrombocytopenia and thrombocytosis. An important gene associated with Thrombocytopenia, Cyclic is THPO (Thrombopoietin). Affiliated tissues include testes, neutrophil and t cells, and related phenotypes are abnormal bleeding and thrombocytopenia

Description from OMIM: 188020

Related Diseases for Thrombocytopenia, Cyclic

Diseases related to Thrombocytopenia, Cyclic via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 10.3
2 thrombocytosis 10.1
3 thrombocytopenic purpura, autoimmune 9.8
4 myasthenia gravis 9.8
5 polycythemia vera 9.8
6 dengue virus 9.8
7 common variable immunodeficiency 9.8
8 human venous malformation 9.8
9 purpura 9.8
10 polycythemia 9.8
11 myasthenia gravis congenital 9.8

Graphical network of the top 20 diseases related to Thrombocytopenia, Cyclic:



Diseases related to Thrombocytopenia, Cyclic

Symptoms & Phenotypes for Thrombocytopenia, Cyclic

Human phenotypes related to Thrombocytopenia, Cyclic:

33
# Description HPO Frequency HPO Source Accession
1 abnormal bleeding 33 HP:0001892
2 thrombocytopenia 33 HP:0001873
3 neutropenia 33 HP:0001875
4 cyclic neutropenia 33 HP:0040289

Symptoms via clinical synopsis from OMIM:

58
Heme:
thrombocytopenia
bleeding diathesis
cyclic neutropenia

Clinical features from OMIM:

188020

Drugs & Therapeutics for Thrombocytopenia, Cyclic

Search Clinical Trials , NIH Clinical Center for Thrombocytopenia, Cyclic

Genetic Tests for Thrombocytopenia, Cyclic

Anatomical Context for Thrombocytopenia, Cyclic

MalaCards organs/tissues related to Thrombocytopenia, Cyclic:

42
Testes, Neutrophil, T Cells

Publications for Thrombocytopenia, Cyclic

Articles related to Thrombocytopenia, Cyclic:

(show all 42)
# Title Authors Year
1
Cyclic thrombocytopenia with statistically significant neutrophil oscillations. ( 29988661 )
2018
2
Cyclic thrombocytopenia synchronizing with the menstrual cycle showing periodic phases of thrombocytopenia and rebound thrombocytosis. ( 28413179 )
2017
3
Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge. ( 28518476 )
2017
4
Cyclic thrombocytopenia related to menstrual cycle: a case report and literature review. ( 25419404 )
2014
5
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. ( 22038676 )
2012
6
Cyclic thrombocytopenia: A case report. ( 27263605 )
2010
7
Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia. ( 19728020 )
2009
8
Successful treatment of cyclic thrombocytopenia with thrombopoietin-mimetic agents: a report of two patients. ( 19484732 )
2009
9
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP. ( 17135540 )
2006
10
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. ( 16044437 )
2005
11
Human cyclic thrombocytopenia and Anaplasma spp. infection. ( 15654914 )
2005
12
Investigation of persistent hypochromic microcytosis unmasks hemoglobin Evanston [alpha 14 (A12) Try--> Arg] in a patient of cyclic thrombocytopenia preceding Takayasu's disease. ( 16273737 )
2005
13
Idiopathic cyclic thrombocytopenia. ( 15572217 )
2005
14
Is complete remission of cyclic thrombocytopenia related to correction of cobalamin deficiency due to H. pylori eradication? ( 15650554 )
2005
15
Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. ( 15205594 )
2004
16
Cyclic thrombocytopenia and polycythemia vera. ( 12574969 )
2003
17
Clonal T cell-mediated cyclic thrombocytopenia. ( 12472588 )
2002
18
Effective treatment of cyclic thrombocytopenia with cepharanthin. ( 10530079 )
1999
19
Cyclic thrombocytopenia in a patient treated with cyclosporine for refractory idiopathic thrombocytopenic purpura. ( 9395191 )
1997
20
Clinical manifestations of infectious canine cyclic thrombocytopenia. ( 9308149 )
1997
21
Serum thrombopoietin levels in cyclic thrombocytopenia. ( 8639873 )
1996
22
Cyclic change of cytokines in a patient with cyclic thrombocytopenia. ( 8757531 )
1996
23
Canine infectious cyclic thrombocytopenia found in Taiwan. ( 8741613 )
1996
24
Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis. ( 7496073 )
1995
25
Megakaryopoiesis in patients with cyclic thrombocytopenia. ( 7577630 )
1995
26
Cyclic thrombocytopenia successfully treated with low dose hormonal contraception. ( 7832199 )
1995
27
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. ( 7871984 )
1994
28
Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies. ( 7529542 )
1994
29
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function. ( 7918035 )
1993
30
Periodic production of antiplatelet autoantibody directed against GPIIIa in cyclic thrombocytopenia. ( 8362605 )
1993
31
[A case of myasthenia gravis complicated by cyclic thrombocytopenia]. ( 1628457 )
1992
32
Danazol therapy for cyclic thrombocytopenia. ( 2012064 )
1991
33
Cell-mediated cyclic thrombocytopenia treated with azathioprine. ( 2012761 )
1991
34
Cyclic thrombocytopenia of apparent autoimmune etiology. ( 2713494 )
1989
35
Idiopathic cyclic thrombocytopenia of childhood. ( 2712241 )
1989
36
Menstrual cyclic thrombocytopenia. ( 2713272 )
1989
37
Serologic diagnosis of infectious cyclic thrombocytopenia in dogs using an indirect fluorescent antibody test. ( 6362502 )
1983
38
Cyclic thrombocytopenia induced by a Rickettsia-like agent in dogs. ( 627738 )
1978
39
Cyclic thrombocytopenia. Case report and review of literature. ( 4598703 )
1974
40
Cyclic thrombocytopenia: a thrombopoietin deficiency? ( 4832304 )
1974
41
Cyclic thrombocytopenia associated with multiple autoantibodies. ( 5797783 )
1969
42
Cyclic thrombocytopenia of acute type. ( 4295269 )
1967

Variations for Thrombocytopenia, Cyclic

Expression for Thrombocytopenia, Cyclic

Search GEO for disease gene expression data for Thrombocytopenia, Cyclic.

Pathways for Thrombocytopenia, Cyclic

GO Terms for Thrombocytopenia, Cyclic

Sources for Thrombocytopenia, Cyclic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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