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ITP
MCID: THR100
MIFTS: 68

Thrombocytopenic Purpura, Autoimmune (ITP)

Categories: Blood diseases, Bone diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Thrombocytopenic Purpura, Autoimmune

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MalaCards integrated aliases for Thrombocytopenic Purpura, Autoimmune:

Name: Thrombocytopenic Purpura, Autoimmune 58 77 60 13
Idiopathic Thrombocytopenic Purpura 58 12 77 54 15 41
Autoimmune Thrombocytopenic Purpura 12 54 15 17
Immune Thrombocytopenic Purpura 58 12 60 74
Itp 58 54 60
Immune Thrombocytopenia 60 64
Thrombocytopenia Due to Platelet Alloimmunization 74
Purpura, Thrombocytopenic, Idiopathic 45
Immune Thrombocytopenic Purpura; Itp 58
Thrombocytopenic Purpura Autoimmune 54
Purpura Thrombocytopenic Idiopathic 56
Primary Thrombocytopenic Purpura 12
Ideopath Thrombocytopenic Pur 12
Autoimmune Thrombocytopenia 74
Idiopathic Purpura 12
Werlhof's Disease 12
Aitp 58

Characteristics:

Orphanet epidemiological data:

60
immune thrombocytopenic purpura
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (France); Age of onset: All ages;

OMIM:

58
Inheritance:
autosomal dominant form


HPO:

33
thrombocytopenic purpura, autoimmune:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:8924
OMIM 58 188030
ICD9CM 36 287.31
MeSH 45 D016553
NCIt 51 C3446
SNOMED-CT 69 13172003 32273002
ICD10 34 D69.3
MESH via Orphanet 46 D016553
ICD10 via Orphanet 35 D69.3
UMLS via Orphanet 75 C0398650
Orphanet 60 ORPHA3002
MedGen 43 C0398650
Sources

Summaries for Thrombocytopenic Purpura, Autoimmune

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NIH Rare Diseases : 54 Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterized by too few platelets in the blood. This is because platelets are being destroyed by the immune system. Symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation. With treatment, the chance of remission (a symptom-free period) is good. Rarely, ITP may become a chronic ailment in adults and reappear, even after remission.

MalaCards based summary : Thrombocytopenic Purpura, Autoimmune, also known as idiopathic thrombocytopenic purpura, is related to amegakaryocytic thrombocytopenia, congenital and thrombocytopenia due to platelet alloimmunization. An important gene associated with Thrombocytopenic Purpura, Autoimmune is FCGR2C (Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene)), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and prostate, and related phenotypes are thromboembolism and thrombocytopenia

Disease Ontology : 12 A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies.

Genetics Home Reference : 26 Immune thrombocytopenia is a disorder characterized by a blood abnormality called thrombocytopenia, which is a shortage of blood cell fragments called platelets that are needed for normal blood clotting.

OMIM : 58 Autoimmune thrombocytopenic purpura is characterized by a low platelet count, normal bone marrow, and the absence of other causes of thrombocytopenia. It is principally a disorder of increased platelet destruction mediated by autoantibodies to platelet-membrane antigens (George et al., 1994). (188030)

PubMed Health : 64 About immune thrombocytopenia: Immune thrombocytopenia (THROM-bo-si-toe-PE-ne-ah), or ITP, is a bleeding disorder. In ITP, the blood doesn't clot as it should. This is due to a low number of blood cell fragments called platelets (PLATE-lets) or thrombocytes (THROM-bo-sites).Platelets are made in your bone marrow along with other kinds of blood cells. They stick together (clot) to seal small cuts or breaks on blood vessel walls and stop bleeding.

Wikipedia : 77 Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet... more...

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Related Diseases for Thrombocytopenic Purpura, Autoimmune

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Diseases related to Thrombocytopenic Purpura, Autoimmune via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 487)
# Related Disease Score Top Affiliating Genes
1 amegakaryocytic thrombocytopenia, congenital 32.1 MPL THPO
2 thrombocytopenia due to platelet alloimmunization 31.8 FCGR2C ITGA2B ITGB3 MPL SELP THPO
3 purpura 31.0 ITGA2B ITGB3 MPL THPO
4 thrombosis 30.4 GP1BA GP6 SELP
5 myelofibrosis 30.2 IFNA2 MPL THPO
6 myelodysplastic syndrome 30.2 DNMT3B IL11 MPL THPO
7 polycythemia vera 30.1 ITGB3 MPL SELP THPO
8 thrombasthenia 30.0 GP1BA ITGA2B ITGB3 SELP
9 thrombocytosis 29.9 IL11 MPL SELP THPO
10 splenomegaly 29.8 IFNA2 MPL
11 bernard-soulier syndrome 29.8 GP1BA ITGA2B ITGB3 THPO
12 thrombocytopenia-absent radius syndrome 29.8 GP1BA MPL THPO
13 clopidogrel resistance 29.8 ITGB3 SELP
14 coronary thrombosis 29.7 GP1BA GP6 ITGB3
15 myocardial infarction 29.6 GP1BA GP6 ITGA2B ITGB3 SELP
16 aplastic anemia 29.5 GATA3 IL11 ITGA2B MPL THPO
17 thrombocytopenia 29.4 GP1BA IL11 ITGA2B ITGB3 MPL THPO
18 blood platelet disease 29.2 GP1BA ITGA2B ITGB3 MPL SELP THPO
19 essential thrombocythemia 28.8 GP1BA IFNA2 IL11 ITGA2B ITGB3 MPL
20 thrombotic thrombocytopenic purpura, acquired 11.8
21 sea-blue histiocyte disease 11.7
22 immunodeficiency, common variable, 8, with autoimmunity 11.5
23 ras-associated autoimmune leukoproliferative disorder 11.4
24 spondyloenchondrodysplasia 11.4
25 purine nucleoside phosphorylase deficiency 11.1
26 inosine triphosphatase deficiency 11.1
27 antiphospholipid syndrome, familial 11.0
28 hepatitis 10.5
29 thrombocytopenia 3 10.4 MPL THPO
30 thrombocythemia 1 10.3 MPL THPO
31 helicobacter pylori infection 10.3
32 leukemia 10.3
33 dyskeratosis congenita, autosomal dominant 6 10.3 MPL THPO
34 lymphoma 10.3
35 lymphocytic leukemia 10.3
36 anemia, autoimmune hemolytic 10.3
37 hemolytic anemia 10.3
38 carotid artery thrombosis 10.3 ITGA2B SELP
39 bleeding disorder, platelet-type, 16 10.3 ITGA2B ITGB3
40 leukemia, acute lymphoblastic 10.2
41 hepatitis c 10.2
42 cytomegalovirus infection 10.2
43 leukocyte adhesion deficiency, type iii 10.2 ITGA2B SELP
44 stroke, ischemic 10.2
45 aspergillosis 10.2
46 nocardiosis 10.2
47 acquired thrombocytopenia 10.2 IL11 THPO
48 systemic lupus erythematosus 10.2
49 b-cell lymphomas 10.2
50 common variable immunodeficiency 10.2

Graphical network of the top 20 diseases related to Thrombocytopenic Purpura, Autoimmune:



Diseases related to Thrombocytopenic Purpura, Autoimmune
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Symptoms & Phenotypes for Thrombocytopenic Purpura, Autoimmune

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Human phenotypes related to Thrombocytopenic Purpura, Autoimmune:

60 33 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 thromboembolism 60 33 hallmark (90%) Very frequent (99-80%) HP:0001907
2 thrombocytopenia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001873
3 petechiae 60 33 frequent (33%) Frequent (79-30%) HP:0000967
4 arterial thrombosis 60 33 frequent (33%) Frequent (79-30%) HP:0004420
5 gastrointestinal hemorrhage 60 33 occasional (7.5%) Occasional (29-5%) HP:0002239
6 epistaxis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000421
7 bruising susceptibility 60 33 occasional (7.5%) Occasional (29-5%) HP:0000978
8 gingival bleeding 60 33 occasional (7.5%) Occasional (29-5%) HP:0000225
9 cerebral hemorrhage 60 33 very rare (1%) Very rare (<4-1%) HP:0001342
10 abnormal bleeding 33 HP:0001892
11 purpura 60 Frequent (79-30%)
12 platelet antibody positive 33 HP:0003454

Symptoms via clinical synopsis from OMIM:

58
Heme:
thrombocytopenia
bleeding diathesis

Lab:
platelet antibody

Clinical features from OMIM:

188030

MGI Mouse Phenotypes related to Thrombocytopenic Purpura, Autoimmune:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 DNMT3B GATA3 GP1BA GP6 IL18 ITGA2B
2 homeostasis/metabolism MP:0005376 9.65 GATA3 GP1BA GP6 IL18 ITGA2B ITGB3
3 immune system MP:0005387 9.32 DNMT3B GATA3 GP6 IL18 ITGA2B ITGB3
Sources

Drugs & Therapeutics for Thrombocytopenic Purpura, Autoimmune

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PubMedHealth treatment related to Thrombocytopenic Purpura, Autoimmune: 64

Treatment for immune thrombocytopenia (ITP) is based on how much and how often you're bleeding and your platelet count.Adults who have mild ITP may not need any treatment, other than watching their symptoms and platelet counts. Adults who have ITP with very low platelet counts or bleeding problems often are treated.The acute (short-term) type of ITP that occurs in children often goes away within a few weeks or months. Children who have bleeding symptoms, other than merely bruising (purpura), usually are treated.Children who have mild ITP may not need treatment other than monitoring and followup to make sure their platelet counts return to normal.

Drugs for Thrombocytopenic Purpura, Autoimmune (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 995)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
3
Artesunate Approved, Investigational Phase 4,Not Applicable 88495-63-0 5464098 6917864
4
Artemether Approved Phase 4,Phase 3 71963-77-4 119380 68911
5
Mefloquine Approved, Investigational Phase 4 53230-10-7 4046
6
Lumefantrine Approved Phase 4,Phase 3 82186-77-4 6437380
7
Amodiaquine Approved, Investigational Phase 4 86-42-0 2165
8
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
9
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
13
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
14
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
15
Polyestradiol phosphate Approved Phase 4 28014-46-2
16
Besifloxacin Approved Phase 4 141388-76-3
17
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
18
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
19
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
20
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 58-14-0 4993
21
Sulfadoxine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 2447-57-6 17134
22
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
23
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
24
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
25
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
26
Ondansetron Approved Phase 4 99614-02-5 4595
27
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
28
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
29
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
30
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613
31
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
32
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 81103-11-9 84029
33
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
34
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
35
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
36
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 32051
37
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
38
Methamphetamine Approved, Illicit Phase 4,Phase 2,Phase 1,Not Applicable 537-46-2 10836
39
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2 68-04-2
40
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
41
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177 70789204
42
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
43
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
44
Hydroxychloroquine Approved Phase 4 118-42-3 3652
45
Azathioprine Approved Phase 4,Phase 3,Not Applicable 446-86-6 2265
46
Dinoprostone Approved Phase 4 363-24-6 5280360
47
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
48
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
49
Ezetimibe Approved Phase 4 163222-33-1 150311
50
Simvastatin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 79902-63-9 54454

Interventional clinical trials:

(show top 50) (show all 1598)
# Name Status NCT ID Phase Drugs
1 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
2 Effectiveness of Artemisinin Combination Regimens in Falciparum Malaria Unknown status NCT00902811 Phase 4 AM(FDC);AM(LT);AL;DP;AA(FDC)
3 Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols Unknown status NCT00742807 Phase 4 Low dose of alfentanil hydrochloride;Normal dose of alfentanil hydrochloride
4 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
5 Graz Study on the Risk of Atrial Fibrillation Unknown status NCT01461434 Phase 4
6 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4 Moxifloxacin;besifloxacin
7 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Unknown status NCT01379391 Phase 4 Recombinant Human Thrombopoietin (rHTPO)
8 tDCS as Add on Therapy for Treatment of Tobacco Dependence by Standardized Behaviour Therapy Unknown status NCT01729507 Phase 4
9 Intermittent Antimalaria Treatment With SP in African Children Unknown status NCT00168948 Phase 4 Sulfadoxin (12.5) Pyrimethamine (250 mg)
10 Efficacy and Safety of Amodiaquine and Amodiaquine-Artesunate Unknown status NCT00238017 Phase 4 amodiaquine-artesunate versus amodiaquine
11 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Unknown status NCT02085551 Phase 4
12 Neurobiological and Cognitive Changes Following Exposure to Either Sevoflurane- or Propofol-based Anesthesia in Children Unknown status NCT03022240 Phase 4 Propofol;Sevoflurane;Ametop;Ondansetron
13 Effects of Pregabalin on Mechanical Hyperalgesia Unknown status NCT00310583 Phase 4 Pregabalin
14 Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia Completed NCT03229746 Phase 4 Hydroxychloroquine;vincristine;azathioprine
15 Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura Completed NCT00467571 Phase 4 lansoprazole, clarithromycin, amoxycillin
16 A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP) Completed NCT01390649 Phase 4
17 Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag Completed NCT00888901 Phase 4 eltrombopag;corticosteroids (Aprednislon)
18 The Study of Different Dose Rituximab in the Treatment of ITP Completed NCT03258866 Phase 4 Rituximab;Rituximab
19 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
20 High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP) Completed NCT01356511 Phase 4 Prednisone;Dexamethasone
21 A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification Completed NCT01021761 Phase 4 Ketorolac Tromethamine;Bromfenac;nepafenac
22 A Comparison of Peak Aqueous Penetration of Acuvail (Ketorolac 0.45%), Xibrom (Bromfenac 0.09%), and Nevanac (Nepafenac 0.1%)in Patients Undergoing Phacoemulsification Completed NCT01001806 Phase 4 Ketorolac Tromethamine 0.45%;bromfenac 0.09%;nepafenac 0.1%
23 The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study Completed NCT00817843 Phase 4 Simvastatin;Simvastatin/Ezetimibe
24 Comparison of Rotating vs. Fixed Platform of the COLUMBUS Knee Prosthesis Completed NCT00822640 Phase 4
25 Treatment of Depression in Adults Completed NCT00073697 Phase 4 Escitalopram
26 Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects Completed NCT00469690 Phase 4 Acular, Xibrom
27 Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease Completed NCT00534651 Phase 4 Paracetamol
28 A Comparison of Post Phacoemulsification Aqueous Flare in Patients Using Ketorolac 0.45% 2 Times Daily (BID) and Bromfenac 0.09% 2 Times Daily (BID) Completed NCT01023724 Phase 4 Ketorolac Tromethamine 0.45%;Bromfenac 0.09%
29 Effect of Thiazolidinedione Treatment Vascular Risk Markers Completed NCT00571506 Phase 4 Rosiglitazone;Pioglitazone
30 Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl Completed NCT00533559 Phase 4 sodium phenylbutyrate;Placebo
31 Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion Completed NCT00188773 Phase 4 N-acetylcysteine, intralipid, heparin
32 Moxifloxacin vs. Polytrim for Conjunctivitis Completed NCT00581542 Phase 4 moxifloxacin;polytrim
33 Mechanism of Growth Hormone Effects on Adipose Tissue Completed NCT00453557 Phase 4 rhGH
34 "TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM Completed NCT00402012 Phase 4 Pioglitazone
35 Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients Completed NCT00347503 Phase 4 ketorolac 0.4%, bromfenac 0.09%
36 Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder Completed NCT00178061 Phase 4
37 Oat Breakfast Satiety Study Completed NCT01372683 Phase 4
38 Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine Completed NCT00975325 Phase 4 Yohimbine;Yohimbine
39 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
40 Raltegravir Kaletra Pharmacokinetics Completed NCT00564772 Phase 4 Raltegravir, lopinavir, ritonavir
41 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
42 Comparing Various Treatments for Achieving and Maintaining Remission of Depression Completed NCT00227955 Phase 4 Imipramine
43 Pharmacokinetic Study of Topically Applied Veregen 15% Compared With Oral Intake of Green Tea Beverage Completed NCT01082302 Phase 4 Polyphenon E (Veregen) 15% ointment
44 Xpert MTB/Rif, a New Tool for the Diagnosis of Pulmonary Tuberculosis in Two Municipalities in Brazil Completed NCT01363765 Phase 4
45 Is Omega-3 Fatty Acid Red Blood Cell (RBC) Saturation Product Dependent? Completed NCT01091714 Phase 4
46 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
47 Effects of Ezetimibe on Postprandial Hyperlipidemia and Endothelial Function Completed NCT00189085 Phase 4 simvastatin and ezetimibe
48 Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study Completed NCT00222820 Phase 4 escitalopram
49 Methamphetamine Abuse Treatment in Patients With AIDS - 1 Completed NCT00000321 Phase 4 Desipramine
50 Dry Age-Related Macular Degeneration (AMD) Treatment With Rheopheresis Trial Completed NCT00751361 Phase 4

Search NIH Clinical Center for Thrombocytopenic Purpura, Autoimmune

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: purpura, thrombocytopenic, idiopathic

Sources

Genetic Tests for Thrombocytopenic Purpura, Autoimmune

About this section
Sources

Anatomical Context for Thrombocytopenic Purpura, Autoimmune

About this section

MalaCards organs/tissues related to Thrombocytopenic Purpura, Autoimmune:

42
Bone, Testes, Prostate, Bone Marrow, Kidney, T Cells, Brain
Sources

Publications for Thrombocytopenic Purpura, Autoimmune

About this section

Articles related to Thrombocytopenic Purpura, Autoimmune:

(show top 50) (show all 2123)
# Title Authors Year
1
A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura. ( 30733882 )
2019
2
A Case of Multiple Cerebral Infarction Preceding Acute Exacerbation of Idiopathic Thrombocytopenic Purpura. ( 30553647 )
2019
3
Rescue therapy for acute idiopathic thrombocytopenic purpura unresponsive to conventional treatment. ( 30642865 )
2019
4
Therapeutic effects of rituximab combined with cyclophosphamide on refractory idiopathic thrombocytopenic purpura. ( 30867701 )
2019
5
Post-Transfusion Purpura Mimicking Idiopathic Thrombocytopenic Purpura: A Case Report. ( 30915450 )
2019
6
Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease. ( 29961815 )
2018
7
Case of atopic dermatitis concurrent with idiopathic thrombocytopenic purpura, whose serum thymus and activation-regulated chemokine level remained undetectable. ( 29399856 )
2018
8
No recurrence of nivolumab-induced idiopathic thrombocytopenic purpura in a metastatic melanoma patient switched to ipilimumab. ( 29400292 )
2018
9
Onset of type 1 diabetes mellitus and heparin-induced thrombocytopenia in a patient with Basedow's disease and idiopathic thrombocytopenic purpura: Novel combination as autoimmune polyglandular syndrome. ( 29905024 )
2018
10
Idiopathic thrombocytopenic purpura in a patient with IgG4-related disease. ( 29888414 )
2018
11
Autoimmune Hepatitis with Concomitant Idiopathic Thrombocytopenic Purpura Diagnosed by Transjugular Liver Biopsy. ( 30631611 )
2018
12
Is Helicobacter pylori infection the potential link between interleukin-17 and idiopathic thrombocytopenic purpura? ( 29856194 )
2018
13
Disseminated herpes simplex virus and varicella zoster virus co-infection in a patient with idiopathic thrombocytopenic purpura. ( 30213467 )
2018
14
Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease. ( 29491289 )
2018
15
Platelet count on preoperative day 1 predicts the long-term responses to laparoscopic splenectomy for Chinese patients with medically refractory idiopathic thrombocytopenic purpura. ( 30477462 )
2018
16
Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid. ( 30531235 )
2018
17
Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature. ( 30588476 )
2018
18
Hyperheptaploidy in idiopathic thrombocytopenic purpura. ( 29567917 )
2018
19
Bilateral visual loss and cerebral infarction after spleen embolization in a trauma patient with idiopathic thrombocytopenic purpura: A case report. ( 29668582 )
2018
20
High-dose Dexamethasone Therapy as the Initial Treatment for Idiopathic Thrombocytopenic Purpura: Protocol for a Multicenter, Open-label, Single Arm Trial. ( 29674771 )
2018
21
Hypogammaglobulinemia Observed One Year after Rituximab Treatment for Idiopathic Thrombocytopenic Purpura. ( 29755528 )
2018
22
Successful Treatment of Idiopathic Thrombocytopenic Purpura After Liver Transplant: A Case Report. ( 30066626 )
2018
23
The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura. ( 30250741 )
2018
24
Helicobacter pylori Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials. ( 30402091 )
2018
25
The association between idiopathic thrombocytopenic purpura and cardiovascular disease: a retrospective cohort study. ( 29297977 )
2018
26
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. ( 29519366 )
2018
27
[Expression and Clinical Significance of Peripheral Blood T cell JAK2/STAT3 mRNA in Chronic Idiopathic Thrombocytopenic Purpura]. ( 30501715 )
2018
28
Systemic lupus erythematosus, following prodromal idiopathic thrombocytopenic purpura, presenting with skin lesions resembling malignant atrophic papulosis. ( 28691162 )
2017
29
Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection. ( 29085203 )
2017
30
Intravenous Immunoglobulin-Induced Profound Bradycardia in a Patient With Idiopathic Thrombocytopenic Purpura. ( 28930759 )
2017
31
The Effective Treatment with Cyclosporine of a Ulcerative Colitis Patient with Concurrent Idiopathic Thrombocytopenic Purpura Who Subsequently Developed Spontaneous Pneumomediastinum. ( 28566594 )
2017
32
Other Extrahepatic Manifestations of Hepatitis C Virus Infection (Pulmonary, Idiopathic Thrombocytopenic Purpura, Nondiabetes Endocrine Disorders). ( 28689597 )
2017
33
Idiopathic thrombocytopenic purpura in childhood, Langerhans cell histiocytosis in adulthood: More than a chance association? ( 28255140 )
2017
34
Idiopathic thrombocytopenic purpura and autoimmune neutropenia induced by prolonged use of nivolumab in Hodgkin's lymphoma. ( 28379290 )
2017
35
An idiopathic thrombocytopenic purpura with polyneuropathy. ( 27427299 )
2017
36
Effectiveness of Helicobacter pylori eradication in pregnant women with idiopathic thrombocytopenic purpura. ( 28718212 )
2017
37
Idiopathic Thrombocytopenic Purpura in Individuals Older than 75 Years: A Rare Series. ( 28863226 )
2017
38
Treatment of Children with Persistent and Chronic Idiopathic Thrombocytopenic Purpura: 4 Infusions of Rituximab and Three 4-Day Cycles of Dexamethasone. ( 29173312 )
2017
39
Spontaneous retrobulbar haemorrhage in idiopathic thrombocytopenic purpura. ( 29237670 )
2017
40
Multiple and recurrent cerebral infarctions in a patient with idiopathic thrombocytopenic purpura. ( 28351532 )
2017
41
Analysis of clinical effects and mechanism of recombinant human interleukin-11 with glucocorticoids for treatment of idiopathic thrombocytopenic purpura. ( 28352325 )
2017
42
Submucosal esophageal hematoma precipitated by chronic idiopathic thrombocytopenic purpura. ( 28491169 )
2017
43
Idiopathic thrombocytopenic purpura: pathogenesis and potential therapeutic approach. ( 28643502 )
2017
44
Association between gene polymorphisms and clinical features in idiopathic thrombocytopenic purpura patients. ( 28654425 )
2017
45
Patterns of care and burden of chronic idiopathic thrombocytopenic purpura in Brazil. ( 28673116 )
2017
46
Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura. ( 28695024 )
2017
47
Paradoxical thrombosis in idiopathic thrombocytopenic purpura. ( 27771836 )
2017
48
Case of twin pregnancy complicated by idiopathic thrombocytopenic purpura treated with intravenous immunoglobulin: Review of the literature. ( 27958258 )
2017
49
Aortic Root Rupture during Transcatheter Aortic Valve Implantation in a Patient with Idiopathic Thrombocytopenic Purpura: Utility of Transesophageal Echocardiography in Early Detection and Description of a Semiconservative Surgical Management Approach. ( 28031654 )
2016
50
CD16 and CD32 Gene Polymorphisms May Contribute to Risk of Idiopathic Thrombocytopenic Purpura. ( 27315784 )
2016
Sources

Variations for Thrombocytopenic Purpura, Autoimmune

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Copy number variations for Thrombocytopenic Purpura, Autoimmune from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21699 1 160500000 165500000 Copy number FCGR2C Idiopathic thrombocytopenic purpura
2 46119 10 77700000 82000000 Copy number BMPR1A Idiopathic thrombocytopenic purpura
3 121460 18 43500000 48200000 Copy number MADH4 Idiopathic thrombocytopenic purpura
Sources

Expression for Thrombocytopenic Purpura, Autoimmune

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Search GEO for disease gene expression data for Thrombocytopenic Purpura, Autoimmune.
Sources

Pathways for Thrombocytopenic Purpura, Autoimmune

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Pathways related to Thrombocytopenic Purpura, Autoimmune according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 65
Show member pathways
 13.29 IFNA2 IL11 IL18 ITGA2B ITGB3 MPL
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.11 GATA3 IFNA2 IL11 IL18 ITGA2B ITGB3
3
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.99 GATA3 GP1BA GP6 IFNA2 ITGA2B ITGB3
4
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.14 IFNA2 IL11 MPL THPO
5
Cell surface interactions at the vascular wall 67
Show member pathways
 12 GP6 ITGB3 SELP
6
Tuberculosis 38
11.99 FCGR2C IFNA2 IL18
7
ECM-receptor interaction 38
Show member pathways
 11.85 GP1BA GP6 ITGA2B ITGB3
8
Platelet activation 38
11.72 GP1BA GP6 ITGA2B ITGB3
9
Integrin alphaIIb beta3 signaling 67
Show member pathways
 11.54 GP1BA ITGA2B ITGB3 MPL THPO
10
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.46 FCGR2C IL18 ITGB3
11
Hematopoietic cell lineage 38
11.34 GP1BA IL11 ITGA2B ITGB3 THPO
12
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 62
11.29 GP6 ITGA2B ITGB3
13
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.23 GP1BA IFNA2 IL11 ITGA2B ITGB3 MPL
14
Development and heterogeneity of the ILC family 1
11.08 GATA3 IL18
15
Ephrin B reverse signaling 1
10.98 ITGA2B ITGB3
16
Signal transduction by L1 67
10.86 ITGA2B ITGB3
17
G-protein signaling_Rap2B regulation pathway 23
10.76 IL11 IL18 ITGA2B ITGB3 THPO
18
Platelet Adhesion to exposed collagen 67
10.61 GP1BA GP6
Sources

GO Terms for Thrombocytopenic Purpura, Autoimmune

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Cellular components related to Thrombocytopenic Purpura, Autoimmune according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 GP1BA GP6 ITGB3 MPL RHD SELP
2 cell surface GO:0009986 9.35 GP1BA GP6 ITGA2B ITGB3 MPL
3 integrin complex GO:0008305 9.26 ITGA2B ITGB3
4 platelet alpha granule membrane GO:0031092 8.8 ITGA2B ITGB3 SELP

Biological processes related to Thrombocytopenic Purpura, Autoimmune according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.73 IFNA2 IL11 IL18 THPO
2 positive regulation of protein kinase B signaling GO:0051897 9.63 GATA3 IL18 THPO
3 platelet degranulation GO:0002576 9.58 ITGA2B ITGB3 SELP
4 cytokine-mediated signaling pathway GO:0019221 9.55 GATA3 IFNA2 IL11 IL18 MPL
5 platelet activation GO:0030168 9.54 GP1BA GP6 ITGB3
6 blood coagulation GO:0007596 9.35 GATA3 GP1BA GP6 IFNA2 ITGB3
7 positive regulation of leukocyte migration GO:0002687 9.32 ITGA2B SELP
8 thrombopoietin-mediated signaling pathway GO:0038163 9.26 MPL THPO
9 platelet aggregation GO:0070527 8.92 GP1BA ITGA2B ITGB3 MPL

Molecular functions related to Thrombocytopenic Purpura, Autoimmune according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IFNA2 IL11 IL18 THPO
2 extracellular matrix binding GO:0050840 9.16 ITGA2B ITGB3
3 fibrinogen binding GO:0070051 8.62 ITGA2B ITGB3
Sources

Sources for Thrombocytopenic Purpura, Autoimmune

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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