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MCID: THR004
MIFTS: 55

Thrombocytosis

Categories: Blood diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Thrombocytosis

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MalaCards integrated aliases for Thrombocytosis:

Name: Thrombocytosis 12 77 30 56 45 15 74
Thrombocythaemia 12

Classifications:

MalaCards categories:
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2228
MeSH 45 D013922
NCIt 51 C35530
SNOMED-CT 69 6631009 79574003
UMLS 74 C0836924
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Summaries for Thrombocytosis

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Disease Ontology : 12 A blood platelet disease that is characterized by the presence of high platelet counts in the blood.

MalaCards based summary : Thrombocytosis, also known as thrombocythaemia, is related to thrombocythemia 1 and polycythemia vera. An important gene associated with Thrombocytosis is JAK2 (Janus Kinase 2), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Hydroxyurea and Anagrelide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and thyroid, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 77 Thrombocythemia (also thrombocytosis) is the presence of high platelet (thrombocyte) counts in the... more...

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Related Diseases for Thrombocytosis

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Diseases related to Thrombocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 418)
# Related Disease Score Top Affiliating Genes
1 thrombocythemia 1 33.2 MPL THPO
2 polycythemia vera 31.7 EPO IL3 JAK2 MPL SELP TET2
3 essential thrombocythemia 31.1 EPO F2 F3 IL11 IL3 JAK2
4 myeloproliferative neoplasm 30.6 JAK2 MPL TET2
5 refractory anemia 30.5 EPO IL3 JAK2 MPL TET2
6 splenomegaly 30.5 EPO JAK2 MPL
7 iron deficiency anemia 30.4 CRP EPO IL6 THPO
8 chromosome 5q deletion syndrome 30.4 EPO TET2
9 poems syndrome 30.3 EPO IL6
10 myeloid leukemia 30.3 CSF2 IL3 JAK2 TET2
11 thrombocytopenia 30.2 F3 IL11 MPL THPO
12 blood platelet disease 30.2 F2 F3 JAK2 MPL SELP SERPINC1
13 polycythemia 30.1 EPO IL3 JAK2 MPL TET2 THPO
14 myelodysplastic myeloproliferative cancer 30.0 CSF2 JAK2 TET2
15 myelofibrosis 30.0 EPO IL3 JAK2 MPL TET2 THPO
16 relapsing polychondritis 30.0 CRP IL6
17 deficiency anemia 30.0 CRP EPO IL11 IL3 IL6 THPO
18 portal hypertension 30.0 F2 JAK2 THPO
19 erythrocytosis, familial, 1 29.9 EPO IL3 JAK2 THPO
20 leukemia, acute myeloid 29.6 CSF2 IL3 JAK2 MPL TET2 THPO
21 central retinal vein occlusion 29.6 F2 IL6 SERPINC1
22 retinal vein occlusion 29.6 F2 IL6 SERPINC1
23 acute monoblastic leukemia 29.6 CSF2 EPO IL6
24 intracranial hypertension 29.6 F2 F3 SERPINC1
25 leukemia, chronic myeloid 29.5 CSF2 EPO IL3 JAK2 MPL THPO
26 thrombosis 29.5 F2 F3 JAK2 SELP SERPINC1
27 peritonitis 29.5 CRP F2 IL6
28 portal vein thrombosis 29.5 F2 JAK2 SELP SERPINC1
29 coronary artery anomaly 29.5 CRP F2 SELP
30 thrombocytopenic purpura, autoimmune 29.4 IL11 MPL SELP THPO
31 myeloma, multiple 29.4 CRP CSF2 EPO IL6 JAK2
32 thrombophilia due to thrombin defect 29.4 F2 F3 SERPINC1
33 intracranial embolism 29.4 F2 SERPINC1
34 bacterial infectious disease 29.4 CRP CSF2 IL6
35 coronary heart disease 1 29.3 CRP IL6 SELP
36 budd-chiari syndrome 29.3 F2 F3 JAK2 SERPINC1
37 sagittal sinus thrombosis 29.2 F2 F3 SERPINC1
38 burns 29.2 CSF2 SERPINC1
39 nervous system disease 29.2 CRP CSF2 IL6
40 von willebrand's disease 29.2 F2 F3 SELP
41 heparin-induced thrombocytopenia 29.2 F3 SERPINC1
42 myelodysplastic syndrome 29.2 CSF2 EPO IL11 IL3 JAK2 MPL
43 acute myocardial infarction 29.1 CRP F3 SELP SERPINC1
44 pancytopenia 29.1 CSF2 EPO IL3 MPL THPO
45 megakaryocytic leukemia 29.1 CSF2 IL11 IL3 JAK2 THPO
46 monocytic leukemia 29.1 CSF2 F3 IL6
47 pulmonary embolism 29.0 CRP F2 F3 SERPINC1
48 thrombophilia due to activated protein c resistance 28.9 F2 F3 SERPINC1
49 thrombophilia 28.9 F2 F3 SERPINC1
50 myocardial infarction 28.8 CRP F2 F3 IL6 SELP SERPINC1

Graphical network of the top 20 diseases related to Thrombocytosis:



Diseases related to Thrombocytosis
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Symptoms & Phenotypes for Thrombocytosis

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MGI Mouse Phenotypes related to Thrombocytosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 CSF2 EPO F2 F3 IL6 JAK2
2 cardiovascular system MP:0005385 10.11 CRP CSF2 EPO F2 F3 IL6
3 homeostasis/metabolism MP:0005376 10.11 CRP CSF2 EPO F2 F3 IL6
4 immune system MP:0005387 10.1 CRP CSF2 EPO F2 F3 IL6
5 embryo MP:0005380 9.98 CSF2 EPO F2 F3 JAK2 MPL
6 integument MP:0010771 9.8 CSF2 EPO F2 F3 IL6 JAK2
7 mortality/aging MP:0010768 9.65 CSF2 EPO F2 F3 IL6 JAK2
8 liver/biliary system MP:0005370 9.63 EPO IL6 JAK2 SELP SERPINC1 TET2
9 respiratory system MP:0005388 9.1 CSF2 EPO F2 F3 IL6 SELP
Sources

Drugs & Therapeutics for Thrombocytosis

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Drugs for Thrombocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 292)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 4,Phase 3,Phase 2,Not Applicable 127-07-1 3657
2
Anagrelide Approved Phase 4,Phase 3,Phase 2 68475-42-3 2182
3
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1401-55-4
4
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
5
Lactitol Investigational Phase 4,Phase 2,Phase 3 585-88-6, 585-86-4 493591
6 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
7 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
9
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
10
Sargramostim Approved, Investigational Phase 3,Phase 1,Phase 2 123774-72-1, 83869-56-1
11
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
12
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
13
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
14
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 38904 498142
15
Fludarabine Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
16
Busulfan Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 55-98-1 2478
17
Aspirin Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-78-2 2244
18
Peginterferon alfa-2a Approved, Investigational Phase 3,Phase 2,Phase 1 198153-51-4 5360545
19
Peginterferon alfa-2b Approved Phase 3 215647-85-1, 99210-65-8
20
Pomalidomide Approved Phase 3,Phase 2,Phase 1 19171-19-8
21
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
22
Dalteparin Approved Phase 3 9005-49-6
23
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
24
Ondansetron Approved Phase 3,Phase 1,Phase 2,Not Applicable 99614-02-5 4595
25
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
26
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
27
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
28
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Not Applicable 93-14-1 3516
29
Dextromethorphan Approved Phase 3 125-71-3 5362449 5360696
30
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
31
Ribavirin Approved Phase 3 36791-04-5 37542
32
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2,Phase 1 302-25-0
33
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 50-24-8 5755
34
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
35
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 83-43-2 6741
36
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2,Phase 1 2921-57-5
37
Melphalan Approved Phase 2, Phase 3,Phase 3,Phase 1 148-82-3 460612 4053
38
Etoposide Approved Phase 2, Phase 3,Phase 1 33419-42-0 36462
39
Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 1 52-24-4 5453
40
Danazol Approved Phase 3,Phase 2 17230-88-5 28417
41
Cytarabine Approved, Experimental, Investigational Phase 3,Phase 2,Phase 1 147-94-4, 65-46-3 6253
42
Hydroxychloroquine Approved Phase 3 118-42-3 3652
43
Mercaptopurine Approved Phase 3 50-44-2 667490
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
45
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
46
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
47 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
48
Prednisolone hemisuccinate Experimental Phase 3,Phase 2,Phase 1 2920-86-7
49 Anesthetics Phase 3
50 Anesthetics, Dissociative Phase 3

Interventional clinical trials:

(show top 50) (show all 289)
# Name Status NCT ID Phase Drugs
1 A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients Completed NCT00202644 Phase 4 Anagrelide;Hydroxyurea
2 Exploratory Phase II Study of INC424 Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
3 Anagre Cap. in Patients With High-Risk Essential Thrombocythemia Recruiting NCT03232177 Phase 4 Anagre Cap.
4 CINC424A2X01B Rollover Protocol Recruiting NCT02386800 Phase 4 Ruxolitinib
5 Efficacy and Safety of rhTPO and Eltrombopag in Patients With Primary Immune Thrombocytopenia (ITP) Recruiting NCT03771378 Phase 4 rhTPO;eltrombopag
6 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
7 Anagrelide Retard in Essential Thrombocythemia Completed NCT02076815 Phase 3 Anagrelide retard;Thromboreductin
8 Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET) Completed NCT01259856 Phase 3 PEGASYS;Hydroxyurea;Aspirin
9 Anagrelide Retard vs. Placebo: Efficacy and Safety in "At-risk" Patients With Essential Thrombocythaemia Completed NCT01230775 Phase 3 Anagrelide retard;Placebo
10 Effect of SPD422 on Platelet Lowering and Safety in Japanese Adults With At Risk Essential Thrombocythaemia Completed NCT01214915 Phase 3 Anagrelide Hydrochloride
11 Anagrelide vs. Hydroxyurea - Efficacy and Tolerability Study in Patients With Essential Thrombocythaemia Completed NCT01065038 Phase 3 Anagrelide;Hydroxyurea
12 Long-term Safety of SPD422 in Japanese Adults With Essential Thrombocythaemia Completed NCT01467661 Phase 3 SPD422 (anagrelide hydrochloride)
13 A Clinical Study of Ruxolitinib in Patients With Primary Myelofibrosis (PM), Post-polycythemia Vera (PV) Myelofibrosis, or Post-essential Thrombocythemia (ET) Myelofibrosis Completed NCT02087059 Phase 3 Ruxolitinib
14 INC424 for Patients With Primary Myelofibrosis, Post Polycythemia Myelofibrosis or Post-essential Thrombocythemia Myelofibrosis. Completed NCT01493414 Phase 3 INC424
15 COntrolled MyeloFibrosis Study With ORal JAK Inhibitor Treatment: The COMFORT-I Trial Completed NCT00952289 Phase 3 Ruxolitinib;Placebo
16 Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II: The COMFORT-II Trial Completed NCT00934544 Phase 3 INC424/INCB018424;Best Available Therapy (BAT)
17 Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis Completed NCT01437787 Phase 3 SAR302503;Placebo
18 High-Dose Gleevec Alone or in Combination With Peg-Intron and GM-CSF in Early Phase Chronic Myelogenous Leukemia (CML) Completed NCT00050531 Phase 3 Gleevec;Peg-alpha interferon (Peg-Intron);Sargramostim (GM-CSF)
19 Phase-3 Double-Blind, Placebo-Controlled Study of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion-Dependence Myelofibrosis and RBC-Transfusion-Dependence Completed NCT01178281 Phase 3 Pomalidomide 0.5 mg;Placebo
20 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
21 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
22 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
23 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
24 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
25 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
26 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
27 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
28 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
29 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
30 Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Benefit Subjects With Hepatitis C Liver Disease Completed NCT00529568 Phase 3 eltrombopag;placebo
31 Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Subjects With Hepatitis C Related Liver Disease Completed NCT00516321 Phase 3 eltrombopag;placebo
32 A Study of Tocilizumab in Patients With Active Polyarticular Juvenile Idiopathic Arthritis Completed NCT00988221 Phase 3 Tocilizumab;Placebo
33 A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA) Completed NCT00642460 Phase 3 tocilizumab [RoActemra/Actemra];Placebo;Non-steroidal anti-inflammatory drugs (NSAIDs);methotrexate;corticosteroids
34 Hydroxyurea Versus Aspirin and Hydroxyurea in Essential Thrombocythemia Recruiting NCT02611973 Phase 3 Hydroxyurea treatment (HU)
35 An Efficacy and Safety Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Recruiting NCT03755518 Phase 3 FEDRATINIB
36 Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children Recruiting NCT03939637 Phase 3 Eltrombopag;Steroids;IVIG;Rho(D) Immune Globulin
37 Efficacy of Momelotinib Versus Best Available Therapy in Anemic or Thrombocytopenic Subjects With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MF Active, not recruiting NCT02101268 Phase 3 Momelotinib;Best Available Therapy (BAT)
38 The Ruxolitinib Versus Best Available Therapy Trial in Patients With High Risk ET in Second Line Active, not recruiting NCT02962388 Phase 2, Phase 3 Anagrelide;Ruxolitinib (JAKAVI®);IFNα/ PegIFNα
39 Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis Active, not recruiting NCT01969838 Phase 3 Momelotinib;Ruxolitinib;Placebo to match momelotinib;Placebo to match ruxolitinib
40 A Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasms Active, not recruiting NCT01387763 Phase 3 PegIntron;Pegasys;PegIntron;Pegasys;Hydrea
41 A Trial of Eltrombopag or Intravenous Immune Globulin Before Surgery for Immune Thrombocytopenia Patients Active, not recruiting NCT01621204 Phase 3 Eltrombopag;IVIG infusion
42 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
43 An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Not yet recruiting NCT03952039 Phase 3 FEDRATINIB;Best Available Therapy (BAT)
44 Hydroxychloroquine Versus Placebo: Impact on Thrombotic Relapse in Primary Antiphospholipid Syndrome Not yet recruiting NCT03540810 Phase 3 Hydroxychloroquine;Placebo
45 Oral Pacritinib Versus Best Available Therapy to Treat Myelofibrosis With Thrombocytopenia Terminated NCT02055781 Phase 3 Pacritinib;Best Available Therapy
46 Oral Pacritinib Versus Best Available Therapy to Treat Myelofibrosis Terminated NCT01773187 Phase 3 Pacritinib;Best Available Therapy
47 A Study of the Efficacy of MK-0683 in Patients With Polycythaemia Vera and Essential Thrombocythaemia Unknown status NCT00866762 Phase 2 HDAC inhibitor (MK-0683)
48 LBH589 (Panobinostat) for the Treatment of Myelofibrosis Unknown status NCT01298934 Phase 1, Phase 2 LBH589
49 CEP-701 (Lestaurtinib) in Myelofibrosis Unknown status NCT00668421 Phase 1, Phase 2 CEP-701 (Lestaurtinib)
50 Open-Label Study of Oral CEP-701 (Lestaurtinib) in Patients With Polycythemia Vera or Essential Thrombocytosis Completed NCT00586651 Phase 2 lestaurtinib

Search NIH Clinical Center for Thrombocytosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: thrombocytosis

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Genetic Tests for Thrombocytosis

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Genetic tests related to Thrombocytosis:

# Genetic test Affiliating Genes
1 Thrombocytosis 30
Sources

Anatomical Context for Thrombocytosis

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MalaCards organs/tissues related to Thrombocytosis:

42
Myeloid, Bone Marrow, Thyroid, Testes, Spleen, Kidney, T Cells
Sources

Publications for Thrombocytosis

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Articles related to Thrombocytosis:

(show top 50) (show all 1669)
# Title Authors Year
1
Prognostic value of thrombocytosis in patients undergoing surgery for colorectal cancer with synchronous liver metastases. ( 30937817 )
2019
2
The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters. ( 30635630 )
2019
3
Thrombocytosis as a Rare Paraneoplastic Syndrome Occurring in Hepatocellular Carcinoma: A Case Report. ( 31019620 )
2019
4
Marked Thrombocytosis and Megakaryocytic Dysplasia in NPM1 Mutated De-Novo Acute Myeloid Leukemia. ( 30988586 )
2019
5
Coexpression of ETV6/MDS1/EVI1 and ETV6/EVI1 fusion transcripts in acute myeloid leukemia with t(3;12)(q26.2;p13) and thrombocytosis. ( 30526151 )
2019
6
A Case of SF3B1-Positive Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis ( 30468430 )
2019
7
Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis. ( 30726782 )
2019
8
Acute ST-segment Elevation Myocardial Infarction as the First Manifestation of Essential Thrombocytosis. ( 31011495 )
2019
9
Association of pretreatment thrombocytosis with prognosis in ovarian cancer: a systematic review and meta-analysis. ( 30479089 )
2019
10
The role of hepcidin, GDF15, and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients ( 30761871 )
2019
11
Refractory anemia with ring sideroblasts (RARS) and RARS with thrombocytosis: "2019 Update on Diagnosis, Risk-stratification, and Management". ( 30618061 )
2019
12
Once- versus twice-daily aspirin treatment in patients with essential thrombocytosis. ( 29442537 )
2019
13
Extreme reactive thrombocytosis in an infant: Much ado about nothing? ( 30251331 )
2019
14
Thrombocytosis Is a Risk Factor for Surgical Site Infections after Colon Resection: A Prospective Observational Study. ( 30256728 )
2019
15
Pulmonary Artery Catheter Thrombus in a Patient With Essential Thrombocytosis: A Case Report. ( 30312177 )
2019
16
Approximately 1% of chronic myeloid leukaemia cases present with isolated thrombocytosis and express common major breakpoints: a finding from a laboratory audit. ( 30477881 )
2019
17
Platelet miR-28 expression level and thrombocytosis in MPN patients. ( 30480878 )
2019
18
A Review and Assessment of Drug-Induced Thrombocytosis. ( 30525921 )
2019
19
Therapeutic thrombocytapheresis for extreme thrombocytosis after chemotherapy in essential thrombocytosis. ( 30624802 )
2019
20
Pretreatment thrombocytosis predict poor prognosis in patients with endometrial carcinoma: a systematic review and meta-analysis. ( 30646853 )
2019
21
Thrombocytosis is linked to increased cancer risk, study finds. ( 30696627 )
2019
22
Asymptomatic late thrombocytosis is a common finding in very preterm infants even in the absence of erythropoietin treatment. ( 30732496 )
2019
23
Thrombocytosis as a Predictor of Serious Bacterial Infection in Febrile Infants. ( 30739929 )
2019
24
Reactive thrombocytosis in acute infectious diseases: Prevalence, characteristics and timing. ( 30795883 )
2019
25
Revisiting diagnostic criteria for myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist. ( 30811101 )
2019
26
Reversible iatrogenic paraparesis secondary to masked hypokalaemia in thrombocytosis-associated pseudohyperkalaemia. ( 30904892 )
2019
27
Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis. ( 30926777 )
2019
28
Thrombopoietin Contributes to Extreme Thrombocytosis After Pediatric Pancreatectomy With Islet Autotransplantation. ( 31091211 )
2019
29
Difficulty distinguishing essential thrombocythaemia from polycythaemia vera in children with JAK2 V617F-positive myeloproliferative neoplasms. ( 29767848 )
2019
30
A phase III randomized, multicentre, double blind, active controlled trial to compare the efficacy and safety of two different anagrelide formulations in patients with essential thrombocythaemia - the TEAM-ET 2·0 trial. ( 30919941 )
2019
31
Next generation sequencing redefines a triple negative essential thrombocythaemia as double-positive with rare mutations on JAK2 V617 and MPL W515 hotspots. ( 31087331 )
2019
32
Essential thrombocythaemia treated with recombinant interferon: 'real world' United Kingdom referral centre experience. ( 31090926 )
2019
33
Marked rebound thrombocytosis in response to glucocorticoids in a patient with acquired amegakaryocytic thrombocytopenia. ( 30416171 )
2018
34
The course of acquired von Willebrand syndrome during pregnancy among patients with essential thrombocytosis. ( 29654448 )
2018
35
Preoperative SCC-Ag and thrombocytosis as predictive markers for pelvic lymphatic metastasis of squamous cervical cancer in early FIGO stage. ( 29760805 )
2018
36
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
37
Pediatric Chronic Myeloid Leukemia Presenting With Extreme Thrombocytosis Simulating Essential Thrombocythemia. ( 29668550 )
2018
38
The prognostic role of pretreatment thrombocytosis in gastric cancer: A systematic review and meta-analysis. ( 30075601 )
2018
39
Spurious Thrombocytosis in the Setting of Hemolytic Anemia and Microcytosis Secondary to Extensive Burn Injury ( 29391327 )
2018
40
Factors associated with ultrasound-guided water enema reduction for pediatric intussusception in resource-limited setting: potential predictive role of thrombocytosis and anemia. ( 29459045 )
2018
41
Is thrombocytosis always an indicator of autosplenectomy in patients with systemic lupus erythematosus? ( 29119304 )
2018
42
Plasmablastic Lymphoma in an Immunocompetent Patient with MDS/MPN with Ring Sideroblasts and Thrombocytosis-A Case Report. ( 30524760 )
2018
43
Myelodysplastic syndrome with fibrosis and complex karyotype arising in a patient with essential thrombocythaemia. ( 30173238 )
2018
44
Anemia with thrombocytosis in an elderly male: a case of myelodysplastic syndrome-myeloproliferative neoplasm with ringed sideroblasts and thrombocytosis. ( 30370419 )
2018
45
Lenalidomide therapy in patients with myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T). ( 29067707 )
2018
46
Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. ( 29282219 )
2018
47
Correlation of mutation status and morphological changes in essential thrombocythaemia and myelofibrosis. ( 30097170 )
2018
48
Comparison of JAK2V617F -positive essential thrombocythaemia and early primary myelofibrosis: The impact of mutation burden and histology. ( 28509339 )
2018
49
Chronic Myeloid Leukemia with b3a3 (e14a3) Fusion: A Rare BCR/ABL Rearrangement Presenting with Thrombocytosis - Does MTHFR Polymorphism Matter. ( 30140211 )
2018
50
Reactive thrombocytosis resulting from frequent blood donations as an extremely rare cause of ST Segment Elevation Myocardial Infarction in the case of a 19-year-old male. ( 30586983 )
2018
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Variations for Thrombocytosis

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Expression for Thrombocytosis

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Search GEO for disease gene expression data for Thrombocytosis.
Sources

Pathways for Thrombocytosis

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Pathways related to Thrombocytosis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 65
Show member pathways
 13.43 CSF2 EPO F2 IL11 IL3 IL6
2
TGF-Beta Pathway 65
Show member pathways
 13.36 EPO F2 IL11 IL3 IL6 JAK2
3
Akt Signaling 65
Show member pathways
 13.25 CSF2 IL11 IL3 IL6 JAK2 THPO
4
PAK Pathway 65
Show member pathways
 13.13 CSF2 IL11 IL3 IL6 JAK2 THPO
5
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.99 CSF2 F2 F3 IL3 JAK2 MPL
6
p70S6K Signaling 65
Show member pathways
 12.89 F2 IL3 IL6 JAK2 THPO
7
Kit receptor signaling pathway 1
Show member pathways
 12.03 EPO IL3 JAK2
8
Formation of Fibrin Clot (Clotting Cascade) 67
Show member pathways
 12.02 F2 F3 SERPINC1
9
G beta-gamma signalling through PI3Kgamma 67
Show member pathways
 12 CSF2 IL3 JAK2
10
Complement and coagulation cascades 1 38
11.95 F2 F3 SERPINC1
11
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.95 IL11 IL3 IL6 JAK2 THPO
12
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.94 IL11 IL3 IL6 THPO
13
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 11.92 CSF2 EPO IL11 IL3 IL6 JAK2
14
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.89 CSF2 F2 IL6
15
AGE-RAGE signaling pathway in diabetic complications 38
11.78 F3 IL6 JAK2
16
Integrin alphaIIb beta3 signaling 67
Show member pathways
 11.77 F2 MPL THPO
17
Jak-Stat Signaling Pathway (sino) 68
11.74 EPO IL3 IL6 JAK2
18
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.73 CSF2 IL6 JAK2
19
Visual Cycle in Retinal Rods 65
11.73 CRP JAK2 MPL THPO
20
Rheumatoid arthritis 38
11.71 CSF2 IL11 IL6
21
Hematopoietic cell lineage 38
11.62 CSF2 EPO IL11 IL3 IL6 THPO
22
Interleukin-6 family signaling 67
Show member pathways
 11.5 IL11 IL6 JAK2
23
Differentiation Pathway 1
11.39 EPO IL11 IL3 IL6
24
Hematopoietic Stem Cell Differentiation 1
11.35 CSF2 EPO IL3 IL6
25
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.23 CSF2 EPO IL11 IL3 IL6 MPL
26
Development_Thrombopoetin signaling via JAK-STAT pathway 23
11.14 CRP JAK2 MPL THPO
27
Cytokines and Inflammatory Response 1
11.09 CSF2 IL11 IL3 IL6
28
G-protein signaling_RhoB regulation pathway 23
11.08 CSF2 IL11 IL3 IL6
29
Overview of nanoparticle effects 1
10.9 CRP IL6
30
G-protein signaling_Rap2B regulation pathway 23
10.87 CSF2 IL11 IL3 IL6 THPO
Sources

GO Terms for Thrombocytosis

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Cellular components related to Thrombocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CRP CSF2 EPO F2 F3 IL11
2 extracellular space GO:0005615 9.36 CRP CSF2 EPO F2 F3 IL11

Biological processes related to Thrombocytosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.8 CSF2 EPO F2 IL11 IL3 IL6
2 blood coagulation GO:0007596 9.73 F2 F3 JAK2 SERPINC1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IL11 IL3 IL6 JAK2
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 F2 JAK2 SELP
5 hemostasis GO:0007599 9.63 F2 F3 SERPINC1
6 acute-phase response GO:0006953 9.62 CRP EPO F2 IL6
7 positive regulation of cell proliferation GO:0008284 9.56 CSF2 EPO F2 IL11 IL3 IL6
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 CSF2 EPO IL3 IL6 JAK2
9 myeloid cell differentiation GO:0030099 9.54 TET2 THPO
10 interleukin-6-mediated signaling pathway GO:0070102 9.52 IL6 JAK2
11 regulation of blood coagulation GO:0030193 9.51 F2 SERPINC1
12 negative regulation of lipid storage GO:0010888 9.49 CRP IL6
13 thrombopoietin-mediated signaling pathway GO:0038163 9.4 MPL THPO
14 cytokine-mediated signaling pathway GO:0019221 9.17 CSF2 F3 IL11 IL3 IL6 JAK2

Molecular functions related to Thrombocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CSF2 EPO IL11 IL3 IL6 THPO
2 growth factor activity GO:0008083 9.1 CSF2 F2 IL11 IL3 IL6 THPO
Sources

Sources for Thrombocytosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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