MCID: THR082
MIFTS: 46

Thrombophilia Due to Activated Protein C Resistance

Categories: Genetic diseases, Blood diseases, Rare diseases

Aliases & Classifications for Thrombophilia Due to Activated Protein C Resistance

MalaCards integrated aliases for Thrombophilia Due to Activated Protein C Resistance:

Name: Thrombophilia Due to Activated Protein C Resistance 57 75 29 13 6 73
Activated Protein C Resistance 57 76 75 44 73
Thrombophilia Due to Factor V Leiden 57 75 29 6
Apc Resistance 57 75 55
Thrombophilia Due to Deficiency of Activated Protein C Cofactor 57 75
Proc Cofactor Deficiency 57 75
Pccf Deficiency 57 75
Thrombophilia V 57 75
Thph2 57 75
Thrombophilia, Susceptibility to, Due to Factor V Leiden 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
most cases are caused by the factor v leiden mutation (r506q, )
onset of symptoms usually in adulthood
thrombosis triggered by pregnancy, oral contraceptives, trauma, surgery
homozygotes have more severe disease with earlier onset of thrombosis


HPO:

32
thrombophilia due to activated protein c resistance:
Inheritance autosomal dominant inheritance
Onset and clinical course adult onset


Classifications:



Summaries for Thrombophilia Due to Activated Protein C Resistance

OMIM : 57 Thrombophilia due to activated protein C resistance is due to a mutation in the F5 gene that renders factor V resistant to cleavage and inactivation by activated protein C (PROC; 612283) and results in a tendency to thrombosis. See also factor V deficiency (227400), an allelic disorder resulting in a hemorrhagic diathesis due to lack of factor V. The most common mutation that causes this disorder is referred to as factor V Leiden (R506Q; 612309.0001), named after the town in the Netherlands where Bertina et al. (1994) discovered the defect. Homozygosity increases the risk of thrombotic complications to a greater extent than heterozygosity. However, heterozygous presence of the mutation may be combined with defects in other genes in the clotting pathway to contribute to the disorder. Expressivity is variable and influenced by environment. (188055)

MalaCards based summary : Thrombophilia Due to Activated Protein C Resistance, also known as activated protein c resistance, is related to budd-chiari syndrome and hemophilia a. An important gene associated with Thrombophilia Due to Activated Protein C Resistance is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Related phenotypes are deep venous thrombosis and prolonged partial thromboplastin time

UniProtKB/Swiss-Prot : 75 Thrombophilia due to activated protein C resistance: A hemostatic disorder due to defective degradation of factor V by activated protein C. It is characterized by a poor anticoagulant response to activated protein C resulting in tendency to thrombosis.

Wikipedia : 76 Activated protein C resistance (APCR) is a hemostatic disorder characterized by a poor anticoagulant... more...

Related Diseases for Thrombophilia Due to Activated Protein C Resistance

Diseases in the Thrombophilia family:

Thrombophilia Due to Thrombin Defect Thrombophilia Due to Activated Protein C Resistance
Thrombophilia, Familial, Due to Decreased Release of Tissue Plasminogen Activator Thrombophilia Due to Thrombomodulin Defect
Prothrombin-Related Thrombophilia

Diseases related to Thrombophilia Due to Activated Protein C Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 budd-chiari syndrome 32.0 APOH F2 F3 F5 MTHFR SERPINC1
2 hemophilia a 28.8 F10 F3 F5 F8 F9 VWF
3 pulmonary embolism 26.0 APOH F10 F2 F3 F5 F9
4 thrombophilia 22.1 APOH F10 F2 F3 F5 F8
5 factor v leiden thrombophilia 11.5
6 protein z deficiency 11.3
7 may-thurner syndrome 11.0 APOH F5
8 acanthamoeba keratitis 10.9 APOH F5
9 paracetamol poisoning 10.9 F2 F5
10 pregnancy loss, recurrent 1 10.8 APOH F5
11 breast reconstruction 10.8 APOH F8
12 mesenteric vascular occlusion 10.8 F2 MTHFR
13 splenic infarction 10.8 APOH F2
14 hemoglobin e disease 10.8 F2 F5
15 neonatal stroke 10.7 MTHFR SERPINE1
16 unilateral absence of a pulmonary artery 10.7 THBD VWF
17 factor v and factor viii, combined deficiency of, 2 10.7 F5 F8
18 hemorrhagic fever 10.7 F2 F3 SERPINC1
19 porencephaly 10.7 F2 F5 MTHFR
20 fainting 10.7 F8 VWF
21 severe pre-eclampsia 10.7 APOH F5 SERPINC1
22 blood protein disease 10.7 F2 MTHFR SERPINC1
23 sticky platelet syndrome 10.7 F5 SERPINC1 SERPINE1
24 hepatitis a 10.7 F2 F3 SERPINC1
25 arteritic anterior ischemic optic neuropathy 10.7 F2 F5 MTHFR
26 inferior vena cava interruption 10.7 F5 MTHFR SERPINE1
27 ischemic neuropathy 10.7 F2 MTHFR
28 thrombocytosis 10.6 F2 F3 SERPINC1
29 alcohol-related birth defect 10.6 F2 F3 F8
30 lateral sinus thrombosis 10.6 F9 MTHFR
31 amaurosis fugax 10.6 F5 MTHFR SERPINE1
32 heparin-induced thrombocytopenia 10.6 F10 F3 SERPINC1
33 von willebrand disease, type 2 10.6 F8 VWF
34 von willebrand disease, type 3 10.6 F8 VWF
35 homocystinuria 10.6 F5 MTHFR SERPINC1
36 subendocardial myocardial infarction 10.6 F2 SERPINC1 SERPINE1
37 chronic thromboembolic pulmonary hypertension 10.6 F2 FGA
38 cerebral palsy 10.6 F2 F5 MTHFR
39 scott syndrome 10.6 F10 F2 F5
40 qualitative platelet defect 10.6 F2 F3 VWF
41 shwartzman phenomenon 10.6 F3 SERPINE1 THBD
42 active peptic ulcer disease 10.6 F2 VWF
43 infective endocarditis 10.6 APOH F2 SERPINE1
44 mercury poisoning 10.5 PLAT THBD
45 sagittal sinus thrombosis 10.5 F2 F3 F5 SERPINC1
46 cerebral sinovenous thrombosis 10.5 APOH F2 F3 F5
47 quebec platelet disorder 10.5 F10 F5 SERPINE1
48 papilledema 10.5 APOH F2
49 ischemic colitis 10.5 APOH F2 F5 SERPINC1
50 sneddon syndrome 10.5 APOH F2 F5 SERPINC1

Graphical network of the top 20 diseases related to Thrombophilia Due to Activated Protein C Resistance:



Diseases related to Thrombophilia Due to Activated Protein C Resistance

Symptoms & Phenotypes for Thrombophilia Due to Activated Protein C Resistance

Symptoms via clinical synopsis from OMIM:

57
Cardiovascular Vascular:
venous thrombosis

Prenatal Manifestations Delivery:
increased fetal loss

Prenatal Manifestations Maternal:
increased risk for preeclampsia

Laboratory Abnormalities:
resistance to activated protein c
poor anticoagulant response to exogenous activated protein c as measured by the activated partial thromboplastin time (aptt)


Clinical features from OMIM:

188055

Human phenotypes related to Thrombophilia Due to Activated Protein C Resistance:

32
# Description HPO Frequency HPO Source Accession
1 deep venous thrombosis 32 HP:0002625
2 prolonged partial thromboplastin time 32 HP:0003645
3 resistance to activated protein c 32 HP:0012175
4 preeclampsia 32 HP:0100602
5 hypercoagulability 32 HP:0100724

MGI Mouse Phenotypes related to Thrombophilia Due to Activated Protein C Resistance:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 PF4 PLAT F8 APOH F10 F9
2 cardiovascular system MP:0005385 10.23 F5 F10 F9 F2 FGA F3
3 hematopoietic system MP:0005397 10.21 PF4 F8 F9 F2 FGA F3
4 immune system MP:0005387 10.11 F8 F9 F2 FGA F3 SERPINE1
5 mortality/aging MP:0010768 10.03 PLAT F8 APOH F10 F9 F2
6 integument MP:0010771 9.97 F5 F2 FGA F3 MTHFR SERPINE1
7 liver/biliary system MP:0005370 9.8 F5 F9 FGA SERPINC1 SERPINE1 THBD
8 nervous system MP:0003631 9.65 MTHFR F5 F2 FGA F3 SERPINC1
9 reproductive system MP:0005389 9.28 F8 F10 F2 FGA MTHFR PLAT

Drugs & Therapeutics for Thrombophilia Due to Activated Protein C Resistance

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome Completed NCT02833194

Search NIH Clinical Center for Thrombophilia Due to Activated Protein C Resistance

Cochrane evidence based reviews: activated protein c resistance

Genetic Tests for Thrombophilia Due to Activated Protein C Resistance

Genetic tests related to Thrombophilia Due to Activated Protein C Resistance:

# Genetic test Affiliating Genes
1 Thrombophilia Due to Activated Protein C Resistance 29 F5
2 Thrombophilia Due to Factor V Leiden 29

Anatomical Context for Thrombophilia Due to Activated Protein C Resistance

Publications for Thrombophilia Due to Activated Protein C Resistance

Articles related to Thrombophilia Due to Activated Protein C Resistance:

# Title Authors Year
1
[Initial experience in the diagnosis of thrombophilia due to activated protein C resistance]. ( 9173574 )
1997

Variations for Thrombophilia Due to Activated Protein C Resistance

UniProtKB/Swiss-Prot genetic disease variations for Thrombophilia Due to Activated Protein C Resistance:

75
# Symbol AA change Variation ID SNP ID
1 F5 p.Arg534Gln VAR_001213 rs6025
2 F5 p.Arg334Thr VAR_013621 rs118203906
3 F5 p.Arg2102His VAR_017329
4 F5 p.Ile387Thr VAR_032698 rs118203911
5 F5 p.Cys613Arg VAR_032699

ClinVar genetic disease variations for Thrombophilia Due to Activated Protein C Resistance:

6
(show top 50) (show all 276)
# Gene Variation Type Significance SNP ID Assembly Location
1 F5 NM_000130.4(F5): c.1601G> A (p.Arg534Gln) single nucleotide variant risk factor rs6025 GRCh37 Chromosome 1, 169519049: 169519049
2 F5 NM_000130.4(F5): c.1601G> A (p.Arg534Gln) single nucleotide variant risk factor rs6025 GRCh38 Chromosome 1, 169549811: 169549811
3 F5 NM_000130.4(F5): c.1001G> C (p.Arg334Thr) single nucleotide variant Pathogenic rs118203906 GRCh37 Chromosome 1, 169524537: 169524537
4 F5 NM_000130.4(F5): c.1001G> C (p.Arg334Thr) single nucleotide variant Pathogenic rs118203906 GRCh38 Chromosome 1, 169555299: 169555299
5 F5 NM_000130.4(F5): c.439G> T (p.Glu147Ter) single nucleotide variant Pathogenic rs118203912 GRCh37 Chromosome 1, 169529939: 169529939
6 F5 NM_000130.4(F5): c.439G> T (p.Glu147Ter) single nucleotide variant Pathogenic rs118203912 GRCh38 Chromosome 1, 169560701: 169560701
7 F5 NM_000130.4(F5): c.1160T> C (p.Ile387Thr) single nucleotide variant Pathogenic rs118203911 GRCh37 Chromosome 1, 169521931: 169521931
8 F5 NM_000130.4(F5): c.1160T> C (p.Ile387Thr) single nucleotide variant Pathogenic rs118203911 GRCh38 Chromosome 1, 169552693: 169552693
9 F5 NM_000130.4(F5): c.6665A> G (p.Asp2222Gly) single nucleotide variant Likely benign rs6027 GRCh37 Chromosome 1, 169483561: 169483561
10 F5 NM_000130.4(F5): c.6665A> G (p.Asp2222Gly) single nucleotide variant Likely benign rs6027 GRCh38 Chromosome 1, 169514323: 169514323
11 F5 NM_000130.4(F5): c.6443T> C (p.Met2148Thr) single nucleotide variant Likely benign rs9332701 GRCh37 Chromosome 1, 169484767: 169484767
12 F5 NM_000130.4(F5): c.6443T> C (p.Met2148Thr) single nucleotide variant Likely benign rs9332701 GRCh38 Chromosome 1, 169515529: 169515529
13 F5 NM_000130.4(F5): c.5419+12A> G single nucleotide variant Likely benign rs6009 GRCh37 Chromosome 1, 169498834: 169498834
14 F5 NM_000130.4(F5): c.5419+12A> G single nucleotide variant Likely benign rs6009 GRCh38 Chromosome 1, 169529596: 169529596
15 F5 NM_000130.4(F5): c.5290A> G (p.Met1764Val) single nucleotide variant Likely benign rs6030 GRCh37 Chromosome 1, 169498975: 169498975
16 F5 NM_000130.4(F5): c.5290A> G (p.Met1764Val) single nucleotide variant Likely benign rs6030 GRCh38 Chromosome 1, 169529737: 169529737
17 F5 NM_000130.4(F5): c.4095C> T (p.Thr1365=) single nucleotide variant Likely benign rs9332607 GRCh38 Chromosome 1, 169540995: 169540995
18 F5 NM_000130.4(F5): c.4095C> T (p.Thr1365=) single nucleotide variant Likely benign rs9332607 GRCh37 Chromosome 1, 169510233: 169510233
19 F5 NM_000130.4(F5): c.3948C> T (p.Leu1316=) single nucleotide variant Likely benign rs9287090 GRCh37 Chromosome 1, 169510380: 169510380
20 F5 NM_000130.4(F5): c.3948C> T (p.Leu1316=) single nucleotide variant Likely benign rs9287090 GRCh38 Chromosome 1, 169541142: 169541142
21 F5 NM_000130.4(F5): c.3853C> A (p.Leu1285Ile) single nucleotide variant Likely benign rs1046712 GRCh37 Chromosome 1, 169510475: 169510475
22 F5 NM_000130.4(F5): c.3853C> A (p.Leu1285Ile) single nucleotide variant Likely benign rs1046712 GRCh38 Chromosome 1, 169541237: 169541237
23 F5 NM_000130.4(F5): c.3804T> C (p.Ser1268=) single nucleotide variant Likely benign rs1800594 GRCh37 Chromosome 1, 169510524: 169510524
24 F5 NM_000130.4(F5): c.3804T> C (p.Ser1268=) single nucleotide variant Likely benign rs1800594 GRCh38 Chromosome 1, 169541286: 169541286
25 F5 NM_000130.4(F5): c.2773A> G (p.Lys925Glu) single nucleotide variant Likely benign rs6032 GRCh37 Chromosome 1, 169511555: 169511555
26 F5 NM_000130.4(F5): c.2773A> G (p.Lys925Glu) single nucleotide variant Likely benign rs6032 GRCh38 Chromosome 1, 169542317: 169542317
27 F5 NM_000130.4(F5): c.2594A> G (p.His865Arg) single nucleotide variant Likely benign rs4525 GRCh37 Chromosome 1, 169511734: 169511734
28 F5 NM_000130.4(F5): c.2594A> G (p.His865Arg) single nucleotide variant Likely benign rs4525 GRCh38 Chromosome 1, 169542496: 169542496
29 F5 NM_000130.4(F5): c.2573A> G (p.Lys858Arg) single nucleotide variant Likely benign rs4524 GRCh37 Chromosome 1, 169511755: 169511755
30 F5 NM_000130.4(F5): c.2573A> G (p.Lys858Arg) single nucleotide variant Likely benign rs4524 GRCh38 Chromosome 1, 169542517: 169542517
31 F5 NM_000130.4(F5): c.2450A> C (p.Asn817Thr) single nucleotide variant Likely benign rs6018 GRCh37 Chromosome 1, 169511878: 169511878
32 F5 NM_000130.4(F5): c.2450A> C (p.Asn817Thr) single nucleotide variant Likely benign rs6018 GRCh38 Chromosome 1, 169542640: 169542640
33 F5 NM_000130.4(F5): c.2425C> T (p.Pro809Ser) single nucleotide variant Likely benign rs6031 GRCh37 Chromosome 1, 169511903: 169511903
34 F5 NM_000130.4(F5): c.2425C> T (p.Pro809Ser) single nucleotide variant Likely benign rs6031 GRCh38 Chromosome 1, 169542665: 169542665
35 F5 NM_000130.4(F5): c.2301A> G (p.Ser767=) single nucleotide variant Likely benign rs6021 GRCh37 Chromosome 1, 169512027: 169512027
36 F5 NM_000130.4(F5): c.2301A> G (p.Ser767=) single nucleotide variant Likely benign rs6021 GRCh38 Chromosome 1, 169542789: 169542789
37 F5 NM_000130.4(F5): c.2289A> G (p.Glu763=) single nucleotide variant Likely benign rs6024 GRCh37 Chromosome 1, 169512039: 169512039
38 F5 NM_000130.4(F5): c.2289A> G (p.Glu763=) single nucleotide variant Likely benign rs6024 GRCh38 Chromosome 1, 169542801: 169542801
39 F5 NM_000130.4(F5): c.2235T> C (p.Asn745=) single nucleotide variant Likely benign rs6017 GRCh38 Chromosome 1, 169542855: 169542855
40 F5 NM_000130.4(F5): c.2235T> C (p.Asn745=) single nucleotide variant Likely benign rs6017 GRCh37 Chromosome 1, 169512093: 169512093
41 F5 NM_000130.4(F5): c.2208C> T (p.Ile736=) single nucleotide variant Likely benign rs6016 GRCh37 Chromosome 1, 169512120: 169512120
42 F5 NM_000130.4(F5): c.2208C> T (p.Ile736=) single nucleotide variant Likely benign rs6016 GRCh38 Chromosome 1, 169542882: 169542882
43 F5 NM_000130.4(F5): c.1926C> A (p.Thr642=) single nucleotide variant Likely benign rs6037 GRCh37 Chromosome 1, 169513583: 169513583
44 F5 NM_000130.4(F5): c.1926C> A (p.Thr642=) single nucleotide variant Likely benign rs6037 GRCh38 Chromosome 1, 169544345: 169544345
45 F5 NM_000130.4(F5): c.1716G> A (p.Glu572=) single nucleotide variant Likely benign rs6036 GRCh37 Chromosome 1, 169515726: 169515726
46 F5 NM_000130.4(F5): c.1716G> A (p.Glu572=) single nucleotide variant Likely benign rs6036 GRCh38 Chromosome 1, 169546488: 169546488
47 F5 NM_000130.4(F5): c.1380C> T (p.Asn460=) single nucleotide variant Likely benign rs6015 GRCh37 Chromosome 1, 169519894: 169519894
48 F5 NM_000130.4(F5): c.1380C> T (p.Asn460=) single nucleotide variant Likely benign rs6015 GRCh38 Chromosome 1, 169550656: 169550656
49 F5 NM_000130.4(F5): c.1242A> G (p.Lys414=) single nucleotide variant Likely benign rs6035 GRCh37 Chromosome 1, 169521849: 169521849
50 F5 NM_000130.4(F5): c.1242A> G (p.Lys414=) single nucleotide variant Likely benign rs6035 GRCh38 Chromosome 1, 169552611: 169552611

Expression for Thrombophilia Due to Activated Protein C Resistance

Search GEO for disease gene expression data for Thrombophilia Due to Activated Protein C Resistance.

Pathways for Thrombophilia Due to Activated Protein C Resistance

Pathways related to Thrombophilia Due to Activated Protein C Resistance according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 APOH F10 F2 F3 F5 F8
2
Show member pathways
12.63 F10 F2 F3 F5 F8 F9
3
Show member pathways
12.13 F2 MTHFR PLAT PLG SERPINE1
4
Show member pathways
12.03 F10 F2 F3 F5 F8 F9
5 11.8 F3 PLG SERPINE1
6
Show member pathways
11.73 F10 F2 F9
7 11.68 F3 SERPINE1 THBD
8
Show member pathways
11.66 F2 FGA VWF
9 11.61 F10 F2 F3 F5 F8 F9
10 11.44 PLAT PLG SERPINE1
11 11.34 F2 FGA VWF
12 11.3 FGA PLAT PLG
13 10.87 F2 PLG
14 10.74 PLAT PLG SERPINE1 SERPINF2
15 10.72 F10 F2 F9

GO Terms for Thrombophilia Due to Activated Protein C Resistance

Cellular components related to Thrombophilia Due to Activated Protein C Resistance according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 APOH F3 FGA PLAT PLG SERPINF2
2 extracellular region GO:0005576 9.86 APOH F10 F2 F3 F5 F8
3 extracellular matrix GO:0031012 9.85 APOH F3 PLAT SERPINE1 VWF
4 blood microparticle GO:0072562 9.83 F2 FGA PLG SERPINC1 SERPINF2
5 endoplasmic reticulum lumen GO:0005788 9.8 F10 F2 F5 F8 F9 FGA
6 Golgi lumen GO:0005796 9.69 F10 F2 F9
7 platelet alpha granule GO:0031091 9.58 F5 FGA VWF
8 fibrinogen complex GO:0005577 9.49 FGA SERPINF2
9 intrinsic component of external side of plasma membrane GO:0031233 9.48 F10 F3
10 platelet alpha granule lumen GO:0031093 9.23 F5 F8 FGA PF4 PLG SERPINE1
11 extracellular exosome GO:0070062 10.1 APOH F2 F3 F9 FGA PLAT
12 extracellular space GO:0005615 10 APOH F2 F3 F5 F8 F9

Biological processes related to Thrombophilia Due to Activated Protein C Resistance according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.95 F2 F5 FGA PLG SERPINC1
2 ER to Golgi vesicle-mediated transport GO:0006888 9.93 F10 F2 F5 F8 F9
3 platelet degranulation GO:0002576 9.91 APOH F5 F8 FGA PF4 PLG
4 fibrinolysis GO:0042730 9.85 F2 FGA PLAT PLG SERPINE1 SERPINF2
5 platelet activation GO:0030168 9.83 F2 F8 FGA PF4 VWF
6 blood coagulation, intrinsic pathway GO:0007597 9.8 APOH F10 F2 F8 F9 VWF
7 negative regulation of endopeptidase activity GO:0010951 9.77 SERPINC1 SERPINE1 SERPINF2
8 negative regulation of peptidase activity GO:0010466 9.77 SERPINC1 SERPINE1 SERPINF2
9 acute-phase response GO:0006953 9.74 F2 F8 SERPINF2
10 signal peptide processing GO:0006465 9.73 F10 F2 F9
11 blood coagulation GO:0007596 9.73 F10 F2 F3 F5 F8 F9
12 negative regulation of blood coagulation GO:0030195 9.7 APOH SERPINE1 THBD
13 positive regulation of blood coagulation GO:0030194 9.69 APOH F2 SERPINE1
14 plasminogen activation GO:0031639 9.67 APOH FGA PLAT
15 regulation of blood coagulation GO:0030193 9.65 APOH F2 SERPINC1
16 peptidyl-glutamic acid carboxylation GO:0017187 9.63 F10 F2 F9
17 negative regulation of fibrinolysis GO:0051918 9.63 APOH F2 PLG SERPINE1 SERPINF2 THBD
18 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
19 negative regulation of plasminogen activation GO:0010757 9.58 SERPINE1 SERPINF2
20 blood coagulation, extrinsic pathway GO:0007598 9.58 F10 F3 F9
21 hemostasis GO:0007599 9.36 F10 F2 F3 F5 F8 F9

Molecular functions related to Thrombophilia Due to Activated Protein C Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.8 F10 F2 F9 PLAT PLG
2 signaling receptor binding GO:0005102 9.77 F2 FGA PLAT PLG SERPINE1
3 peptidase inhibitor activity GO:0030414 9.65 SERPINC1 SERPINE1 SERPINF2
4 phospholipid binding GO:0005543 9.63 APOH F10 F3
5 heparin binding GO:0008201 9.62 APOH F2 PF4 SERPINC1
6 serine-type endopeptidase inhibitor activity GO:0004867 9.61 SERPINC1 SERPINE1 SERPINF2
7 serine-type peptidase activity GO:0008236 9.55 F10 F2 F9 PLAT PLG
8 serine-type endopeptidase activity GO:0004252 9.43 F10 F2 F3 F9 PLAT PLG
9 protease binding GO:0002020 9.02 F3 SERPINC1 SERPINE1 SERPINF2 VWF
10 protein binding GO:0005515 10.19 APOH F10 F2 F3 F5 F8

Sources for Thrombophilia Due to Activated Protein C Resistance

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69 SNOMED-CT via HPO
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