MCID: THR016
MIFTS: 50

Thrombophlebitis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Thrombophlebitis

MalaCards integrated aliases for Thrombophlebitis:

Name: Thrombophlebitis 12 29 54 44 15 70
Phlebitis and Thrombophlebitis of Superficial Vessels of Lower Extremities 12 32
Thrombophlebitis of Superficial Veins of Lower Extremity 12
Thrombophlebitis of a Superficial Leg Vein 12
Superficial Thrombophlebitis of Leg 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3875
ICD9CM 34 451.0
MeSH 44 D013924
NCIt 50 C3410
SNOMED-CT 67 40283005 64156001
ICD10 32 I80.0
UMLS 70 C0040046 C0265057

Summaries for Thrombophlebitis

Disease Ontology : 12 A phlebitis that results from a blood clot in the vessel.

MalaCards based summary : Thrombophlebitis, also known as phlebitis and thrombophlebitis of superficial vessels of lower extremities, is related to lemierre's syndrome and varicose veins. An important gene associated with Thrombophlebitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Collagen chain trimerization and Response to elevated platelet cytosolic Ca2+. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 73 Thrombophlebitis is a phlebitis (inflammation of a vein) related to a thrombus (blood clot). When it... more...

Related Diseases for Thrombophlebitis

Diseases related to Thrombophlebitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 665)
# Related Disease Score Top Affiliating Genes
1 lemierre's syndrome 32.1 MTHFR F3 F2 CRP
2 varicose veins 31.3 VWF SERPINC1 PLAT MTHFR F5 F2
3 lateral sinus thrombosis 30.4 SERPINC1 MTHFR F2
4 mastoiditis 30.3 SERPINC1 MTHFR F2 CRP
5 buerger disease 30.3 CRP APOH
6 cavernous sinus thrombosis 30.2 SERPINC1 F3 F2 CRP
7 chronic venous insufficiency 30.1 SERPINE1 PLAT MTHFR F2 CRP
8 toxic shock syndrome 30.1 SERPINC1 F3 CRP
9 subdural empyema 30.1 F2 CRP
10 dysfibrinogenemia, congenital 30.0 SERPINC1 PLAT F5 F2
11 cellulitis 30.0 F3 F2 CRP ALB
12 porencephaly 29.9 MTHFR F5 F2
13 typhoid fever 29.9 F2 CRP ALB
14 abducens nerve disease 29.8 SERPINC1 F2 CRP
15 protein c deficiency 29.8 SERPINE1 SERPINC1 PROC MTHFR F5 F2
16 urinary tract infection 29.8 TGFB1 CRP
17 arteriosclerosis 29.8 SERPINE1 SERPINC1 F3 CRP
18 pulmonary edema 29.7 SERPINC1 F2 CRP
19 otitis media 29.7 PLG CRP ALB
20 venous insufficiency 29.7 VWF SERPINE1 PLAT MTHFR F5 F2
21 hemorrhoid 29.6 F2 CRP ALB
22 antithrombin iii deficiency 29.6 SERPINC1 PLG MTHFR F5 F2 APOH
23 cholecystolithiasis 29.6 TGFB1 CRP
24 eclampsia 29.6 SERPINC1 MTHFR F2 ALB
25 infective endocarditis 29.5 SERPINE1 F2 CRP APOH
26 intracranial hypertension 29.5 SERPINE1 SERPINC1 MTHFR F5 F3 F2
27 hemopericardium 29.5 PLG F3 F2 CRP
28 angiodysplasia 29.4 VWF F8 F3
29 pleural empyema 29.4 PLG F2 CRP ALB
30 beta-thalassemia 29.4 SERPINC1 MTHFR F5 F2 CRP
31 syphilis 29.4 F2 CRP APOH ALB
32 paralytic ileus 29.3 F2 CRP ALB
33 cranial nerve palsy 29.3 SERPINC1 CRP ALB
34 endocarditis 29.3 SERPINE1 SERPINC1 PLAT F2 CRP APOH
35 klebsiella pneumonia 29.2 PLAT CRP ALB
36 post-thrombotic syndrome 29.2 SERPINE1 SERPINC1 PLG PLAT F8 F5
37 homocystinuria 29.2 SERPINC1 MTHFR F8 F5 ALB
38 pericardial effusion 29.2 F3 F2 CRP ALB
39 protein s deficiency 29.2 SERPINC1 PROS1 PROC MTHFR F5 F3
40 hyperuricemia 29.2 MTHFR CRP ALB
41 brain edema 29.2 PLAT CRP ALB
42 sagittal sinus thrombosis 29.2 SERPINC1 PLG F8 F5 F3 F2
43 hepatic infarction 29.1 SERPINC1 F3 F2 APOH ALB
44 cholangitis, primary sclerosing 29.1 F2 CRP ALB
45 bronchopneumonia 29.1 F3 CRP ALB
46 portal hypertension 29.0 VWF TGFB1 F3 F2 ALB
47 necrotizing fasciitis 29.0 PLG CRP ALB
48 urinary tract obstruction 29.0 TGFB1 SERPINE1 CRP ALB
49 factor xii deficiency 29.0 VWF SERPINC1 F7 F5 F3 APOH
50 exanthem 29.0 F3 F2 CRP ALB

Graphical network of the top 20 diseases related to Thrombophlebitis:



Diseases related to Thrombophlebitis

Symptoms & Phenotypes for Thrombophlebitis

MGI Mouse Phenotypes related to Thrombophlebitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ALB APOH CRP F2 F3 F5
2 cardiovascular system MP:0005385 10.3 ALB CRP F2 F3 F5 F7
3 immune system MP:0005387 10.18 ALB CRP F2 F3 F8 PLAT
4 mortality/aging MP:0010768 10.16 ALB APOH F2 F3 F5 F7
5 integument MP:0010771 10.02 F2 F3 F5 MTHFR PLAT PLG
6 liver/biliary system MP:0005370 9.97 ALB F5 MTHFR PLG PROC PROS1
7 muscle MP:0005369 9.76 ALB F2 F3 PLAT PROC PROS1
8 nervous system MP:0003631 9.73 F2 F3 F5 MTHFR PLAT PLG
9 respiratory system MP:0005388 9.17 F2 F3 PLAT PLG PROC SERPINE1

Drugs & Therapeutics for Thrombophlebitis

Drugs for Thrombophlebitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4 9005-49-6
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
3
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
6 Fibrinolytic Agents Phase 4
7 Anticoagulants Phase 4
8 calcium heparin Phase 4
9 Heparin, Low-Molecular-Weight Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antirheumatic Agents Phase 4
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4
13 Cyclooxygenase Inhibitors Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Analgesics Phase 4
16 Salicylates Phase 4
17 Heparinoids Phase 4
18
Amiodarone Approved, Investigational Phase 3 1951-25-3 2157
19
Parnaparin Approved, Investigational Phase 3 9005-49-6
20
Fondaparinux Approved, Investigational Phase 3 104993-28-4
21
Warfarin Approved Phase 3 81-81-2 6691 54678486
22 Cytochrome P-450 CYP3A Inhibitors Phase 3
23 Anti-Arrhythmia Agents Phase 3
24 Sodium Channel Blockers Phase 3
25 Vasodilator Agents Phase 3
26 Potassium Channel Blockers Phase 3
27 Diuretics, Potassium Sparing Phase 3
28 Cytochrome P-450 Enzyme Inhibitors Phase 3
29 Adjuvants, Immunologic Phase 3
30 Immunologic Factors Phase 3
31 Wobenzym Phase 3
32 Serine Proteinase Inhibitors Phase 3
33 Antithrombin III Phase 3
34 PENTA Phase 3
35 Antithrombins Phase 3
36 Factor Xa Inhibitors Phase 3
37 HIV Protease Inhibitors Phase 3
38
protease inhibitors Phase 3
39
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
40 Plasminogen Phase 1
41 Tissue Plasminogen Activator Phase 1
42 Anesthetics

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Prospective, Randomized, Double-blinded Trial of the Efficacy and Safety of Different Doses and Duration of Low Molecular Weight Heparin (Dalteparin) in Superficial Vein Thrombosis Completed NCT01245998 Phase 4 Dalteparin;Dalteparin
2 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4 Dalteparin sodium injection
3 A One Week, Double-Blind, Adaptive, Randomized, Multicenter Study to Compare the Efficacy, Safety and Tolerability of Topical Diclofenac Gel Versus Placebo in Patients With Superficial Thrombophlebitis Completed NCT00377806 Phase 4 Diclofenac gel
4 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
5 The Effect of Intravenous vs. Oral Administration of Amiodarone on the Incidence Rate of Phlebitis Among Patients With Recent Onset of Atrial Fibrillation (AF) Unknown status NCT01817439 Phase 3 Amiodarone
6 Randomized Clinical Study of Different Treatment Doses and Duration of Low Molecular Weight Heparin (Parnaparin) in Superficial Vein Thrombosis Completed NCT00362947 Phase 3 LMWH parnaparin subcutaneously
7 Phlogenzym® in Patients With Acute Thrombophlebitis - Efficacy and Tolerance - Randomised Double-blind Study Phase III With Parallel Groups vs. Placebo According to the Guidelines of Good Clinical Practice (GCP) Completed NCT03470337 Phase 3 Phlogenzym
8 Efficacy and Tolerability of Hirudoid Cream in Prophylaxis and Treatment of Superficial Infusion Thrombophlebitis Completed NCT01943006 Phase 3 Hirudoid cream 0.3 % Mucopolysaccharide polysulfate;Placebo cream without active substance
9 An International, Multicentre, Randomised, Double-blind, Placebo-controlled, Two-parallel Group, Phase III Study to Evaluate the Efficacy and Safety of ARIXTRA (2.5mg Subcutaneously) for the Treatment of Patients With Acute Symptomatic Isolated Superficial Thrombophlebitis of the Lower Limbs to Prevent Thromboembolic Complications Completed NCT00443053 Phase 3 Fondaparinux 2.5mg or placebo
10 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3 warfarin
11 Treatment of Acute Deep Vein Thrombosis of the Lower Extremity With Intraclot, Pulse-Sprayed Recombinant Tissue Plasminogen Activator, Plus Heparin and Warfarin: A Pilot Study Completed NCT00001713 Phase 1 Recombinant Tissue Plasminogen Activator;Heparin;Warfarin
12 Superficial Thrombophlebitis and Venous Thromboembolism: A Large Prospective Epidemiological Study Completed NCT00818688
13 COVID-19 and Deep Venous Thrombosis: a Cross-sectional Study Completed NCT04338932
14 Randomized Comparative Evaluation of Midline Catheters for Thrombophlebitis Recruiting NCT03725293
15 An Investigation Into the Efficacy of Pre-operative Long Saphenous Vein Mapping Using Ultrasound for Use in Coronary Artery Bypass Grafting to Reduce Vein Harvest Site Complications. Terminated NCT02307084
16 Evaluation of Perivascular Venous Vascularization and Inflammation by Contrast-enhanced Ultrasound (CEUS) in Patients With Acute Deep Vein Thrombosis and Superficial Thrombophlebitis - a Pilot Study Terminated NCT01367769

Search NIH Clinical Center for Thrombophlebitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Dalteparin
Dalteparin Sodium
Enoxaparin
heparin
heparin calcium
heparin sodium
HEPARIN SODIUM (BEEF LUNG)
heparin sodium, bovine
heparin sodium, porcine
Tolazoline
Tolazoline Hydrochloride
Warfarin
Warfarin Sodium
WARFARIN SODIUM ISOPROPANOL COMPLEX

Cochrane evidence based reviews: thrombophlebitis

Genetic Tests for Thrombophlebitis

Genetic tests related to Thrombophlebitis:

# Genetic test Affiliating Genes
1 Thrombophlebitis 29

Anatomical Context for Thrombophlebitis

MalaCards organs/tissues related to Thrombophlebitis:

40
Skin, Heart, Lung, Breast, Kidney, Pituitary, Bone

Publications for Thrombophlebitis

Articles related to Thrombophlebitis:

(show top 50) (show all 5702)
# Title Authors PMID Year
1
Continuous infusion of intermediate-purity factor VIII in haemophilia A patients undergoing elective surgery. 54 61
10444285 1999
2
[Thrombophlebitis in a patient with acute Q fever and anticardiolipin antibodies]. 54 61
9139149 1997
3
Effect of recombinant erythropoietin therapy on autoimmunity in systemic lupus erythematosus. 61 54
8023821 1994
4
A critical analysis of 57 cases of Hughes-Stovin syndrome (HSS). A report by the HSS International Study Group (HSSISG). 61
33529654 2021
5
Mondor's disease of the breast: a case series. 61
33810810 2021
6
Impact of Physician Inspection in the Detection of Phlebitis and Factors Contributing to it in Admitted Children of a Tertiary Care Hospital: A Prospective Study. 61
33051788 2021
7
Case of systemic sarcoidosis involving skin lesions that exhibited histological evidence of interstitial granulomatous dermatitis accompanied by widespread thrombophlebitis. 61
33502027 2021
8
Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism. 61
33301828 2021
9
Patients Undergoing Primary Total Joint Arthroplasty with Primary Hypercoagulable States. 61
33470047 2021
10
[Skin diseases as indicators of cancer]. 61
33730256 2021
11
Forget-me-not: Lemierre's syndrome, a case report. 61
33760711 2021
12
Influence of the minimum inhibitory concentration of daptomycin on the outcomes of Staphylococcus aureus bacteraemia. 61
33279686 2021
13
Chest Masculinization Technique and Outcomes in 72 Double-incision Chest-contouring Procedures with Free Nipple Grafting. 61
33747690 2021
14
IJV thrombophlebitis: be wary of the occult. 61
33731404 2021
15
Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy. 61
33156045 2021
16
Multiple thromboembolic events associated with bilateral superior vena cava and anomalous drainage into the left atrium. 61
33526519 2021
17
Rare Complications of Acute Appendicitis: A Case Report. 61
33560955 2021
18
Safety and efficacy of vasopressor administration through midline catheters. 61
33049486 2021
19
Utility of ventriculogallbladder shunts in complex cases of hydrocephalus related to extreme prematurity. 61
33636696 2021
20
Rickets and gross motor delay in a child with atopic dermatitis. 61
33614053 2021
21
An chronic otitis media with effusion complicated with paravertebral abscess: Case report and review of the literature. 61
33450586 2021
22
Complications in Pediatric Acute Mastoiditis: HCUP KID Analysis. 61
33588620 2021
23
Mondor's Disease of the Arm Following Breast Cancer Treatment. 61
33758712 2021
24
Postpartum ovarian vein thrombophlebitis presenting as vaginal bleeding: A case report. 61
33663072 2021
25
Thrombophlebitis of abdominal veins as an unusual cause for acute abdomen: avoiding the diagnostic pitfalls. 61
32583089 2021
26
Idiopathic Ipsilateral External Jugular Vein Thrombophlebitis After Coronavirus Disease (COVID-19) Vaccination. 61
33624509 2021
27
Re: Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy. 61
33630791 2021
28
Postsclerotherapy compression: A systematic review. 61
32791308 2021
29
An Atypical Presentation of Lemierre's Syndrome: Complicated by Thrombotic Thrombocytopenic Purpura. 61
33614331 2021
30
Lemierre's Syndrome with Severe Thrombocytopenia without Disseminated Intravascular Coagulation: A Case Report and Literature Review. 61
33681457 2021
31
Lemierre's syndrome or re-emerging disease: Case report and literature review. 61
33352443 2021
32
Jugular Vein Thrombosis and Anticoagulation Therapy in Lemierre's Syndrome-A Post Hoc Observational and Population-Based Study of 82 Patients. 61
33447643 2021
33
Effect of the vancomycin minimum inhibitory concentration on clinical outcomes in patients with methicillin-susceptible Staphylococcus aureus bacteraemia: a systematic review and meta-analysis. 61
33452189 2021
34
Safety and Feasibility of Phenylephrine Administration Through a Peripheral Intravenous Catheter in a Neurocritical Care Unit. 61
31757173 2021
35
Percutaneous catheter drainage of uncomplicated amoebic liver abscess: prospective evaluation of a clinical protocol for catheter removal and the significance of residual collections. 61
33469690 2021
36
Novel Design of Peripheral Infusion Catheter Improves the Kinetics of Intravenous Drug Release. 61
33415522 2021
37
A missing piece: Fracture of peripheral intravenous cannula, a case report. 61
33383285 2021
38
Results of polidocanol endovenous microfoam in clinical practice. 61
32353594 2021
39
Care cascade for patients with opioid use disorder and serious injection related infections. 61
33733021 2021
40
Neurologic complications of venous thromboembolism. 61
33632445 2021
41
Variations in incidence of venous thromboembolism in low-, middle-, and high-income countries. 61
32142099 2021
42
[Maternal mortality due to venous thromboembolism in France 2013-2015]. 61
33197653 2021
43
[Maternal mortality by stroke in France 2013-2015]. 61
33161190 2021
44
Internal jugular vein thrombosis associated with Granulicatella adiacens. 61
33472803 2021
45
In-Hospital Complications following Arthrotomy versus Arthroscopy for Septic Knee Arthritis: A Cohort-Matched Comparison. 61
31288270 2021
46
Lemierre Syndrome: Unusual Presentation With Superior Ophthalmic Vein Thrombosis. 61
33405462 2021
47
Adventitial Progenitor Cells of Human Great Saphenous Vein Enhance the Resolution of Venous Thrombosis via Neovascularization. 61
33679991 2021
48
Superficial Thrombophlebitis From Intravenous Pentamidine in Hematopoietic Cell Transplantation Recipient. 61
33413823 2021
49
Lemierre syndrome: Current evidence and rationale of the Bacteria-Associated Thrombosis, Thrombophlebitis and LEmierre syndrome (BATTLE) registry. 61
33091703 2020
50
Clinical Pharmacokinetics of Fosfomycin after Continuous Infusion Compared with Intermittent Infusion: a Randomized Crossover Study in Healthy Volunteers. 61
33106259 2020

Variations for Thrombophlebitis

Expression for Thrombophlebitis

Search GEO for disease gene expression data for Thrombophlebitis.

Pathways for Thrombophlebitis

Pathways related to Thrombophlebitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 SERPINC1 PROS1 PROC F8 F7 F5
2
Show member pathways
12.6 VWF TGFB1 SERPINF2 SERPINE1 SERPINC1 PROS1
3
Show member pathways
12.19 SERPINE1 PLG PLAT MTHFR F7 F2
4
Show member pathways
12.17 VWF SERPINF2 SERPINE1 SERPINC1 PROS1 PROC
5
Show member pathways
12.03 TGFB1 PROS1 PROC F2
6 11.93 VWF SERPINF2 SERPINE1 SERPINC1 PROS1 PROC
7
Show member pathways
11.77 PROS1 PROC F7 F2
8 11.74 TGFB1 SERPINE1 PLAT
9 11.7 TGFB1 SERPINE1 F3
10 11.64 VWF TGFB1 F3
11 11.46 SERPINE1 PLG PLAT
12 11.32 TGFB1 PLG PLAT
13 10.85 PROS1 PROC F7 F2
14 10.74 SERPINF2 SERPINE1 PLG PLAT

GO Terms for Thrombophlebitis

Cellular components related to Thrombophlebitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.13 VWF SERPINF2 SERPINE1 SERPINC1 PROS1 PLG
2 extracellular region GO:0005576 10.09 VWF TGFB1 SERPINF2 SERPINE1 SERPINC1 PROS1
3 collagen-containing extracellular matrix GO:0062023 10 VWF TGFB1 SERPINF2 SERPINE1 SERPINC1 PLG
4 cell surface GO:0009986 9.95 TGFB1 SERPINF2 PLG PLAT F3 APOH
5 endoplasmic reticulum lumen GO:0005788 9.91 SERPINC1 PROC F8 F7 F5 F2
6 blood microparticle GO:0072562 9.87 TGFB1 SERPINF2 SERPINC1 PROS1 PLG F2
7 Golgi lumen GO:0005796 9.8 TGFB1 PROS1 PROC F7 F2
8 platelet alpha granule lumen GO:0031093 9.61 VWF TGFB1 SERPINF2 SERPINE1 PROS1 PLG
9 extracellular space GO:0005615 9.55 VWF TGFB1 SERPINF2 SERPINE1 SERPINC1 PROS1
10 platelet alpha granule GO:0031091 9.49 VWF F5
11 serine-type peptidase complex GO:1905286 9.46 F7 F3

Biological processes related to Thrombophlebitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.95 SERPINC1 PROC PLG F5 F2 ALB
2 ER to Golgi vesicle-mediated transport GO:0006888 9.93 PROS1 PROC F8 F7 F5 F2
3 response to hypoxia GO:0001666 9.87 TGFB1 PLAT MTHFR F7
4 hemostasis GO:0007599 9.85 VWF SERPINC1 PROS1 PROC PLG F8
5 negative regulation of endopeptidase activity GO:0010951 9.84 SERPINF2 SERPINE1 SERPINC1 PROS1
6 acute-phase response GO:0006953 9.8 SERPINF2 F8 F2 CRP
7 platelet activation GO:0030168 9.79 VWF F8 F2
8 response to wounding GO:0009611 9.76 VWF TGFB1 F2
9 blood coagulation, intrinsic pathway GO:0007597 9.73 VWF F8 F2 APOH
10 fibrinolysis GO:0042730 9.73 SERPINF2 SERPINE1 PROS1 PLG PLAT F2
11 negative regulation of fibrinolysis GO:0051918 9.72 SERPINF2 SERPINE1 PLG F2 APOH
12 positive regulation of blood coagulation GO:0030194 9.71 SERPINE1 F7 F2 APOH
13 positive regulation of collagen biosynthetic process GO:0032967 9.7 TGFB1 SERPINF2 F2
14 regulation of blood coagulation GO:0030193 9.69 SERPINC1 F2 APOH
15 negative regulation of blood coagulation GO:0030195 9.67 SERPINE1 PROS1 PROC APOH
16 platelet degranulation GO:0002576 9.65 VWF TGFB1 SERPINF2 SERPINE1 PROS1 PLG
17 response to cholesterol GO:0070723 9.61 TGFB1 F7
18 positive regulation of positive chemotaxis GO:0050927 9.6 F7 F3
19 plasminogen activation GO:0031639 9.59 PLAT APOH
20 negative regulation of plasminogen activation GO:0010757 9.58 SERPINF2 SERPINE1
21 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.56 F7 F3
22 blood coagulation, extrinsic pathway GO:0007598 9.55 F7 F3
23 blood coagulation GO:0007596 9.36 VWF SERPINC1 PROS1 PROC PLG PLAT

Molecular functions related to Thrombophlebitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.77 PROC PLG PLAT F7 F2
2 signaling receptor binding GO:0005102 9.65 SERPINE1 PLG PLAT F7 F2
3 chaperone binding GO:0051087 9.61 VWF PLG ALB
4 serine-type endopeptidase inhibitor activity GO:0004867 9.58 SERPINF2 SERPINE1 SERPINC1
5 serine-type peptidase activity GO:0008236 9.55 PROC PLG PLAT F7 F2
6 copper ion binding GO:0005507 9.5 F8 F5 ALB
7 protease binding GO:0002020 9.35 VWF SERPINF2 SERPINE1 SERPINC1 F3
8 serine-type endopeptidase activity GO:0004252 9.1 PROC PLG PLAT F7 F3 F2

Sources for Thrombophlebitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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